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Proteins Associated With The Early Endosome Contribute To De Novo [Psi+] Prion Formation, Jacqueline N. Kivila

Master's Theses (2009 -)

Prion diseases are infectious neurodegenerative disorders associated with Creutzfeldt-Jakob disease, bovine spongiform encephalopathy (“Mad cow” disease) and kuru. In prion disease, a native protein can misfold and further convert a normal version of itself to the misfolded conformation. These misfolded proteins can form aggregates which are associated with these diseases. While much work has been dedicated to understanding how protein aggregates impact cellular health, less is known about the cellular mechanisms that contribute to the formation of the prion. To dissect these mechanisms, we use the budding yeast, Saccharomyces cerevisiae, which provides a powerful tool for studying prion formation. The …

Partial And Full Arc With Dynamicarc Technique In Pencil Beam Scanning Proton Therapy For Bilateral Head And Neck Cancer: A Feasibility And Dosimetric Study, Suresh Rana, Noufal Manthala Padannayil, Shyam Pokharel, Michael Kasper, Hina Saeed

All Publications

Purpose: A novel proton beam delivery method known as DynamicARC spot scanning has been introduced. The current study aims to determine whether the partial proton arc technique, in conjunction with DynamicARC pencil beam scanning (PBS), can meet clinical acceptance criteria for bilateral head and neck cancer (HNC) and provide an alternative to full proton arc and traditional intensity-modulated proton therapy (IMPT).

Method: The study retrospectively included anonymized CT datasets from ten patients with bilateral HNC, all of whom had previously received photon treatment. The clinical target volumes (CTV) were categorized into three levels: CTV_7000, CTV_5950, and CTV_5600. IMPT plans included …

Development Of A Self-Management Tool For Individuals With Seizure Clusters: Trial Design And Methodological Report, Molly Mcvoy, Eytan Hirsch, Luisa Londono, Kari Colón-Zimmermann, Jin Seok Cho, Martha Sajatovic

Faculty Scholarship

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE. Methods: This 2-phase, ongoing clinical trial adapts SMART to integrate RM support for PWE with repetitive seizures. Phase 1, now completed, used input from an advisory board (AB) of PWE, caregivers, and clinicians to adapt the …

Redefining Cancer Photodynamic Therapy With Gold Nanoparticles, Zoey A. Lockwood, Michael R. Jirousek, James P. Basilion, Clemens Burda

Faculty Scholarship

Despite advancements made in treatment options, cancer continues to be one of the leading causes of death worldwide. Photodynamic therapy (PDT) has gained attention as a minimally invasive and highly selective treatment option for cancer. However, challenges due to the hydrophobicity of photosensitizers and their poor tumor selectivity have limited their use in cancer therapy. Recent developments in nanotechnology, particularly the use of gold nanoparticles (AuNPs), help overcome these challenges. AuNPs provide a stable and biocompatible platform to deliver photosensitizers, improving their solubility, stability, and ability to target tumors while reducing side effects. Functionalized AuNPs take advantage of mechanisms like …

Women In Academic Leadership In The East And The West: Navigating Challenges To Attain Key Leadership Positions In Male-Dominated Societies, Ngoc Lan Thi Dang

Journal of Comparative & International Higher Education

No abstract provided.

The Emotional Geographies Of Vietnamese Students In Australia, Anh N.Q. Phan, Ha H. Nguyen, Thuy T. Nguyen, Tho X. Pham

Journal of Comparative & International Higher Education

No abstract provided.

Columns Spring 2025, Southern Adventist University

Alumni Newsletter

Features articles on gamification to increase learning and classroom engagement, summer camp connections, and embracing service.

Voyages Spring 2025 Inner Pages, Florida Southwestern State College

Voyages Magazine

Voyages Magazine: FSW Embracing AI. Spring 2025 inner pages.

The Acth Test Fails To Diagnose Adrenal Insufficiency And Augments Cytokine Production In Sepsis, Dan Hao, Qian Wang, Misa Ito, Jianyao Xue, Ling Guo, Bin Huang, Chieko Mineo, Philip W. Shaul, Xiang An Li

Physiology Faculty Publications

The adrenocorticotropic hormone (ACTH) test diagnoses relative adrenal insufficiency (RAI) or critical illness–related corticosteroid insufficiency (CIRCI). Initially, guidelines recommended corticosteroid/glucocorticoid (GC) therapy for septic patients with RAI, but later trials did not show a survival benefit, leading to updated guidelines that abandon targeting RAI or CIRCI. Recent studies with an RAI mouse model showed a clear survival benefit from GC therapy in mice with RAI, suggesting that inconclusive GC clinical trials might be due to issues with the ACTH test rather than targeting RAI. To investigate, we performed the ACTH test in septic mice. Interestingly, the ACTH test identified most …

Interspecific Sources Of Resistance For Neisseria Gonorrhoeae: Investigating Horizontally Transferred Antimicrobial Resistance Markers, Makenna Swartz

Theses

Antibiotic resistance is a growing public health crisis, limiting treatment options and increasing the burden of infectious diseases. Bacteria can rapidly gain resistance through mutations and horizontal gene transfer (HGT). Understanding these mechanisms is critical for developing strategies to mitigate resistance and preserve antibiotic efficiency. Neisseria gonorrhoeae, the causative agent of gonorrhea, has developed resistance to multiple antibiotics, and has only one remaining treatment option. Commensal species are constantly exposed to antibiotics in humans, and over time acquire resistant mutations that then transfer to pathogenic species through HGT. Investigating these exchanges can provide insight into how resistance evolves and spreads …

The Use Of Robotic Surveillance In The Uae In 2035: Balancing, Innovation, Regulation, And Privacy, Oasha Yousuf Almohier

Theses

This research explores the future of robotic surveillance in the United Arab Emirates (UAE) by 2035, aiming to balance innovation, regulatory oversight, and privacy protection. It investigates the intersection of national security objectives, ethical AI governance, and public trust within the UAE’s rapidly advancing smart city and law enforcement environments. The focus areas include regulatory gaps in current AI laws, ethical concerns such as data privacy and algorithmic bias, and the societal perception of AI-powered surveillance systems. The background of this study stems from the UAE’s ambition to lead in AI deployment, especially within public security initiatives such as autonomous …

Exploring The Impact Of Language Modeling Integration In Classroom Assessment Scoring System (Class) On Language Teaching And Learning In Pre-K Settings: A Comprehensive Analysis Of Teacher-Child Relationships And Interactions, Joy Lee Hernandez

Teaching & Learning Theses & Dissertations

This descriptive research study utilizes a mixed methods design to explore the impact of integrating language modeling into the Classroom Assessment Scoring System (CLASS) on teachers' perspectives on language teaching and learning. Additionally, the study analyzed teacher-child interactions in Pre-K settings in Southeast Virginia, U.S.A.

Observations were conducted in eleven (11) classrooms using the Pre-K CLASS, a key instrument for assessing the quality of teacher-child interactions across domains such as Emotional Support, Classroom Organization, and Instructional Support, which includes Language Modeling. The CLASS tool was supplemented with detailed notetaking to capture both quantitative scores and qualitative nuances of interactions. This …

An Investigation Into The Effectiveness Of High School Models Of Instruction In English Language Arts For Exceptional Education Standard Diploma Students, Lori A. Rath Minton

Dissertations

This study examined the effectiveness of high school instructional models in English Language Arts (ELA) for Exceptional Student Education (ESE) students pursuing a standard diploma. The purpose was to compare self-contained and inclusion models within the framework of the Individuals with Disabilities Education Act (IDEA), emphasizing Free and Appropriate Public Education (FAPE) and the Least Restrictive Environment (LRE). The research was conducted in a medium-sized rural district high school.

The overarching research question was: Based on student test scores, ESSA data, surveys, and interviews with content area teachers, ESE teachers, paraprofessionals, support facilitators, and administrators, how effective are self-contained and …

Gender Differences In Perceived Organizational Support Among Veterans With Posttraumatic Stress Disorder, Elizabeth Gomez

Dissertations

Posttraumatic stress disorder (PTSD) is a well-studied issue within the U.S. military, with data showing military personnel face a higher risk of trauma than the civilian population. Many veterans and service members suffer from PTSD related to their military experiences (Renshaw, 2011). As research has largely focused on protective factors such as social and familial support, little attention has been given to organizational support (Meredith et al., 2011). Perceived organizational support (POS) refers to how individuals perceive the support they receive from their employers, with the military as the primary employer for veterans. This study was designed to explore whether …

Counseling In The Space Between: Counselor Perceptions Of Empathy And Therapeutic Alliance During Videoconferencing-Based Teleplay Therapy Sessions, Robert M. Lima Jr

Dissertations

Children and adolescents experienced a significant increase in mental health challenges during the COVID-19 pandemic (Czeisler et al., 2020; Hertz et al., 2022; Mpofu, 2023; Oberg et al., 2022; Wilkins et al., 2023). With health facilities closed for non-emergent patients, telemental health therapy offered the possibility of support for those experiencing mental health challenges (Chiauzzi et al., 2020; Cooke et al., 2020; Karimi et al., 2022; E. C. Lee et al., 2023; Racine et al., 2020). While numerous past studies conducted over several years confirmed the efficacy of telemental health counseling (e.g., Feijt et al., 2020; Gloff et al., 2015; …

Transforming Optical Vernier Effect Into Coherent Microwave Interference Towards Highly Sensitive Optical Fiber Sensing, Ruimin Jie, Jie Huang, Chen Zhu

Electrical and Computer Engineering Faculty Research & Creative Works

The optical Vernier effect has garnered significant research attention and found widespread applications in enhancing the measurement sensitivity of optical fiber interferometric sensors. Typically, Vernier sensor interrogation involves measuring its optical spectrum across a wide wavelength range using a high-precision spectrometer. This process is further complicated by the intricate signal processing required for accurately extracting the Vernier envelope, which can inadvertently introduce errors that compromise sensing performance. In this work, we introduce a novel approach to interrogating Vernier sensors based on a coherent microwave interference-assisted measurement technique. Instead of measuring the optical spectrum, we acquire the frequency response of the …

Black Students With Disabilities In The Virginia Community College System, David Jerome Sultzer

Educational Leadership & Workforce Development Theses & Dissertations

The advancement of policies and laws to support students with disabilities has increased the roles of students with disabilities in post-secondary institutions. There remains a significant disparity between the population of abled and disabled students and even a more significant disparity between Black and other students with disabilities on post-secondary campuses in the United States. Research has uncovered a fair amount of qualitative literature that speaks to the disparity between Black and other students with disabilities on post-secondary campuses with most of the qualitative literature from the perspective of the Black student with disabilities.

This study examined the perceptions of …

Production Of Biofertilizer And Biohydrogen Via Anaerobic Fermentation Of Ulva Spp.: A Feasibility Study For Reducing Coastal Eutrophication And Generating Clean Energy, Katie Graves

Capstone Projects and Master's Theses

This feasibility study investigates the potential of anaerobic fermentation of Ulva spp., a locally sourced macroalga, using Clostridium acetobutylicum to produce biofertilizer and biohydrogen. It further examines the viability of Ulva as fermentation biomass by identifying seasonal trends in nutrient concentrations of biofertilizer and gas production while determining the impact of the preservation method on gas yield. The biofertilizer used for nutrient analysis was produced from fresh Ulva harvested within 24 hours prior to fermentation. Orthophosphate (PO4-P), nitrite (NO2-N), nitrate (NO3-N), and ammonia (NH3-N) concentrations were analyzed post-fermentation using spectrophotometric flow injection analysis (FIA). Potassium (K+) concentrations were measured using …

Effects Of Density On Morphometrics And Reproductive Physiology In The Bull Kelp (Nereocystis Luetkeana), An Annual Foundation Species, Bennett M. Bugbee

Capstone Projects and Master's Theses

The bull kelp, Nereocystis luetkeana, is the predominant canopy forming kelp along much of the northeastern Pacific. However, it remains largely understudied due to the dynamic nature of its niche coupled with its annual life history. For populations to persist, reproductive sporophytes must release substantial spores to facilitate successful sexual fertilization among male and female gametophytes that will develop into the next cohort of sporophytes. High densities of spores increase the likelihood of completing the alternation of generation life cycle characteristic of kelp genera. Yet those high densities of spores have the potential to result in a high density of …

Seasonality Of Groundfish Community Structure And Habitat Associations On A Mesophotic Reef In Monterey Bay National Marine Sanctuary: Implications For Conservation And Management, Lauren Parker

Capstone Projects and Master's Theses

Management of marine ecosystems requires accurate, quantitative, and spatially explicit information on species distributions at scales that are relevant to the management process (J. Ward et al. 1999). This study investigates fish assemblages at depths between 30 and 40 meters, which are relatively understudied compared to shallower ( < 30 m) waters, surveyed extensively via SCUBA, and deeper (>40 m) waters, which are surveyed using submersibles. This research addresses ecological and management-based questions about seasonal and depth-related shifts in groundfish community structure, the role of oceanographic variables in predicting these shifts, and microhabitat selectivity as predictors of community assemblage. To evaluate species abundance, biomass, diversity, and microhabitat associations associations on …

Llm-Ie: A Python Package For Biomedical Generative Information Extraction With Large Language Models, Enshuo Hsu, Kirk Roberts

Faculty, Staff and Student Publications

Objectives: Despite the recent adoption of large language models (LLMs) for biomedical information extraction (IE), challenges in prompt engineering and algorithms persist, with no dedicated software available. To address this, we developed LLM-IE: a Python package for building complete IE pipelines.

Materials and methods: The LLM-IE supports named entity recognition, entity attribute extraction, and relation extraction tasks. We benchmarked it on the i2b2 clinical datasets.

Results: The sentence-based prompting algorithm resulted in the best 8-shot performance of over 70% strict F1 for entity extraction and about 60% F1 for entity attribute extraction.

Discussion: We developed a Python package, LLM-IE, …

Coyote (Canis Latrans) Macronutrient Consumption And Diet Relative To Seasonality And Urbanization, Katherine C. B. Weiss, Sean C. P. Coogan, Pierre Deviche, Jesse S. Lewis, Savage C. Hess, Jan Schipper, Eric G. Strauss, Beckett Sterner

Biology Faculty Works

Diet selection informs the health, fitness, and behavior of wild predators. Due to assumptions that vertebrate prey contains similar compositions of macronutrients (i.e., protein, carbohydrates, and lipids), whole prey items traditionally define carnivore diets. However, increasing evidence suggests that prey differ in terms of their macronutrient compositions, particularly relative to body size. Furthermore, omnivorous predators, like coyotes (Canis latrans), integrate both prey and nonprey diet items whose macronutrient compositions vary. This is particularly important in urbanized systems, which introduce or alter the distributions of prey (e.g., domestic pets) and nonprey (e.g., ornamental plants) foods in ways that contribute …

Analyzing The Inhibition Of Chemical Compounds On Collagenase In P. Aeruginosa, Elaine Vanterpool

Student Posters

Pseudomonas aeruginosa is an opportunistic pathogen that poses significant challenges in clinical treatment due to its production of collagenase. This bacterium can cause several infections including pneumonia, meningitis, septicemia, and a host of other diseases. Collagenase acts as a key virulence factor by breaking down collagen in the host’s extracellular matrix, allowing bacteria to invade tissues. This study hypothesized that the effects of cell secreted collagenase would be inhibited by metronidazole, vanillin, and silver nanoparticles to reduce the pathogenicity of Ps. aeruginosa related infections. With the use of a spectrophotometric assay, collagenase activity was measured in treated and untreated bacterial …

Jenifer Michaels. A History., Farrah Freibert

Publications

Jenifer Michaels was a legendary subcultural star within the gay liberation film milieu of 1970s Los Angeles. Taking three paths to approaching and interpreting Michaels’s filmic and archival image, this article is structured by an analysis of Michaels’s documentary appearances, her performance in sex films, and her statements published in a textual interview. Working against what I call historiographic gentrification, the article utilizes archival and micro-historical methods to think through Michaels’s subcultural stardom as a nexus for complicating biography, documentary, and the politics of veracity.

Soluble Cd13 Is A Potential Mediator Of Neutrophil-Induced Thrombogenic Inflammation In Sars-Cov-2 Infection, Pei-Suen Tsou, Ramadan A. Ali, Chenyang Lu, Gautam Sule, Carmelo Carmona-Rivera, Serena Lucotti, Yuzo Ikari, Qi Wu, Phillip L. Campbell, Mikel Gurrea-Rubio, Kohei Maeda, Sharon E. Fox, William D. Brodie, Megan N. Mattichak, Caroline Foster, Ajay Tambralli, Srilakshmi Yalavarthi, M Asif Amin, Katarina Kmetova, Bruna Mazetto Fonseca, Emily Chong, Yu Zuo, Michael D. Maile, Luisa Imberti, Arnaldo Caruso, Francesca Caccuri, Virginia Quaresima, Alessandra Sottini, Douglas B. Kuhns, Et Al

School of Medicine Faculty Publications

The soluble variant of the ectopeptidase CD13 (sCD13), released from the cell surface by matrix metalloproteinase 14 (MMP14), is a potent pro-inflammatory mediator, displaying chemotactic, angiogenic, and arthritogenic properties through bradykinin receptor B1 (B1R). We revealed a link between sCD13 and amplified neutrophil-mediated inflammatory responses in SARS-CoV-2 infection. sCD13 was markedly elevated in patients with COVID-19 and correlated with disease severity and variants, ethnicity, inflammation markers, and neutrophil extracellular trap formation (NETosis). Neutrophils treated with sCD13 showed heightened NETosis and chemotaxis, which were inhibited by sCD13 receptor blockade. Meanwhile sCD13 did not induce platelet aggregation. Single-cell analysis of COVID-19 lungs …

Unveiling Marginalised Voices: Female Indentured Labourer’S Narratives In Island Literature, Arifah Arum Candra Hayuningsih

Akda: The Asian Journal of Literature, Culture, Performance

This study examines the lives of female indentured labourers from Java and India, as portrayed in Liliane Saintomer's La Bayou de Nouméa à Jakarta (2016) and Gaiutra Bahadur's Coolie Woman (2013). Both authors, grandchildren of the central characters, offer personal and historical insights. The research explores how these novels enhance our understanding of the complex identities and lived experiences of female indentured labourers in colonial contexts. It investigates memory as a site of resistance, reclaiming silenced narratives and addressing the shared struggles of Javanese and Indian women in plantation life.

Forests And Cycles Of Agrarian Sustenance: Time-To-Event Analysis Of Ecosystem Provisioning Services And Seasonal Food Insecurity, Kamaldeen Mohammed, Daniel Kpienbaareh

Faculty Publications - Geography, Geology, and the Environment

In Savanna ecosystems, cycles of sustenance include periods of food abundance and deficits. In rain-fed agricultural systems, forests are a vital food source that helps households close this cycle. This paper uses cross-sectional data to explore the association between provisioning ecosystem services and timing to food insecurity in forest fringe communities (N = 500). The time to food insecurity analysis revealed a significant difference in the onset of food insecurity among households with varying levels of access to forest provisioning services. Households with access to more than four forest products experienced a slower timing to seasonal insecurity. In contrast, …

Rising From The Ashes : How African American Women From North Tulsa Overcame The Oppressions Of Race, Gender, And Class And Achieved Success, Cynthia A. Talley

ATS Dissertations

No abstract provided.

Physiotherapy In Community-Based Rehabilitation In Middle And Low-Income Countries: A Scoping Review, Er D. Petil Jr., Napoleon R. Caballero

Philippine Journal of Physical Therapy

Introduction: Community-based rehabilitation (CBR) is a widely recognized approach to address the rehabilitation needs of individuals with disabilities in low- and middle-income countries (LMICs). Physical therapy (PT) plays a crucial role within CBR programs. This study aimed to synthesize the current state of literature regarding the integration of PT in CBR programs in LMICs across Asia, Africa, and Latin America, examining key characteristics, reported outcomes, and challenges to implementation.

Methods: A comprehensive review of literature was conducted, focusing on studies published in the past decade. Data were extracted and synthesized in matrix format to compare and contrast findings across the …

Valuing Worker Authenticity, Dallan F. Flake

William & Mary Law Review

Title VII of the Civil Rights Act of 1964 protects workers from discrimination because of their race, color, religion, sex, or national origin. Controversially, courts do not typically extend this protection to individual expression tied to a protected trait, such as a Black employee who wears their hair in dreadlocks or a Latino employee who speaks Spanish on the job. Judicial unwillingness to protect employee self-expression tied to a protected trait causes employees who identify with marginalized groups to suppress their identities to conform with mainstream culture—often at tremendous costs to themselves and the organizations they work for.

This Article …