Digital Commons Network^™

Identification Of Surrogate Biomarkers For Mucopolysaccharidosis Type Iva, Yasuhiko Ago, Shaukat Khan, Kimberly Klipner, Allison Bradford, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis type IVA (MPS IVA, Morquio A syndrome) is a rare inherited disorder characterized by skeletal dysplasia due to deficient N-acetylgalactosamine-6-sulfate sulfatase activity, resulting in glycosaminoglycan (GAG) accumulation. Identifying accurate biomarkers reflecting clinical severity and therapeutic response remains challenging. This study evaluated potential surrogate biomarkers, including N-terminal pro-C-type natriuretic peptide (NT-proCNP), collagen types I and II, mono-sulfated keratan sulfate (KS), di-sulfated KS, and chondroitin-6-sulfate (C6S), in blood and urine samples from 60 patients ranging from 1 to 62 years of age. NT-proCNP levels were significantly elevated in patients of all ages and negatively correlated with growth impairment, especially after 8 …

Participant 012: Reiki Master With Three Months Of Experience (Asian American & White; Female; New York, Usa)

0885: Reiki and Well-Being Interviews

This is an interview about Reiki and its connection with overall well-being with a Reiki Master holding three months of experience (Asian American & White; Female; New York, USA). She was interviewed on May 21, 2025. The participant agreed to the terms outlined in the verbal informed consent form before this interview. Some of the broad conversations during this interview include the full circle moments of finding aspects of spirituality as a young adult, but revising it when you're older; her first experience with a Reiki session being during her Reiki I attunement; Reiki's place in helping participant find self-love …

The Association Between Neighborhood Environment, Social Relations, And The Prevalence Of Irritable Bowel Syndrome, Negin Iranfar

Walden Dissertations and Doctoral Studies

Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction influenced by biological, psychological, and social factors. Stress and socioeconomic influences on IBS have been studied, however few studies have explored the impact of neighborhood and social environments across racial and ethnic groups and sex at birth. The biopsychosocial framework was used to examine whether built environment and social context contribute to IBS prevalence. A cross-sectional analysis of 80,874 participants from the All of Us Research Program was conducted to assess the associations between IBS and six neighborhood and social factors: safety, structure, cohesion, supportive relationships, social relationships, and perceived …

Lack Of Sleep Linked To Negative Body Image In Teens, Clara Turnage

University of Mississippi News

OXFORD, Miss. – Poor sleep quality is often tied to mental health conditions such as anxiety and depression, but new research from the University of Mississippi suggests it may also be related to how teens feel about their appearance.

Comparing Performance Of Aquaponics Systems Using Different Designs And Fish Feeds, Cody G. Willmore

Biology Theses, Dissertations, and Student Creative Activity

Future food production requires sustainable approaches that used both land and water resources efficiently, while remaining economically viable. One approach is aquaponics, the practice which combines hydroponics and aquaculture, as a sustainable food producing system. Aquaponic systems are unique, as the system can be designed to reuse and repurpose locally sourced materials and resources to meet individual needs. However, productivity of these systems can be inefficient or inconsistent, impacting the viability of aquaponics. The first objective of my study was to compare how system design between a do-it yourself reclaimed-materials aquaponic system and a prefabricated aquaponic setup affects water quality …

Unmasking Midfoot Pain: A Rare Case Report Of The Bipartite Medial Cuneiform Management, Andrew Silman, Syed Ahmed

Advocate GME

No abstract provided.

Global Dna Methylation Differences Involving Germline Structural Variation Impact Gene Expression In Pediatric Brain Tumors, Fengju Chen, Yiqun Zhang, Wei Li, Fritz J Sedlazeck, Lanlan Shen, Chad J Creighton

Children’s Nutrition Research Center Staff Publications

The extent of genetic variation and its influence on gene expression across multiple tissue and cellular contexts is still being characterized, with germline Structural Variants (SVs) being historically understudied. DNA methylation also represents a component of normal germline variation across individuals. Here, we combine germline SVs (by short-read sequencing) with tumor DNA methylation across 1292 pediatric brain tumor patients. For thousands of methylation probes for CpG Islands (CGIs) or enhancers, rare and common SV breakpoints upstream or downstream associate with differential methylation in tumors spanning various histologic types, a significant subset involving genes with SV-associated differential expression. Cancer predisposition genes …

Reducing Surgery For Pediatric Posttonsillectomy Hemorrhage Using Tranexamic Acid: A Quality Improvement Initiative, Laura A. Petrauskas, Janavi Sethurathnam, Ansley J. Kunnath, Rahul K. Sharma, John Ceremsak, Ryan H. Belcher, James D. Phillips, Jay A. Werkhaven, Amy S. Whigham, Lyndy J. Wilcox, Christopher T. Wootten, Frank W. Virgin, Jason S. Park

School of Medicine Faculty Publications

Objective: Evaluate the use of tranexamic acid (TXA) and observation as a management option for pediatric patients presenting with posttonsillectomy hemorrhage (PTH). Study Design: Retrospective analysis of a prospectively implemented quality improvement initiative with a historical control comparison group. Setting: Tertiary children's hospital. Methods: Patients < 18 years of age who underwent adenotonsillectomy (AT) and returned to the Emergency Department for PTH were included. Patients who were stable without large volume or active bleeding were given intravenous TXA and admitted for overnight observation. Data were compared in a before-and-after analysis: preprotocol (April 2022 to March 2023) versus postprotocol (April 2023 to March 2024). For cost-effectiveness analysis, we analyzed aggregated claims data from a commercial claims database. Results: Preprotocol 1800 adenotonsillectomies were performed, and 40 procedures were performed for control of hemorrhage (2.2 per 100 AT). Postprotocol 2356 adenotonsillectomies were performed, and 30 procedures were performed to control hemorrhage (1.3 per 100 AT) showing a significant reduction in return to the operating room (relative risk [RR] = 0.59, 95% confidence interval [CI] [0.358, 0.916], P-value.020). There were no reported adverse events attributable to TXA. An estimated 21 surgeries were avoided, and 26 additional patients were observed in the hospital during the postprotocol period, for an estimated net cost savings of $174,970. Conclusion: The implementation of a standardized TXA protocol significantly reduced the need for return to the operating room for PTH in pediatric patients, without complications and with net cost savings to the health care system.

A Multi-Level Gene-Diet Interaction Analysis Of Fish Oil And 14 Polyunsaturated Fatty Acid Traits Identifies The Fads And Gpr12 Loci, Susan Adanna Ihejirika, Alexandra Huong Chiang, Aryaman Singh, Eunice Stephen, Han Chen, Kaixiong Ye

Faculty, Staff and Student Publications

Fish oil supplements (FOS) are known to alter circulating levels of polyunsaturated fatty acids (PUFAs) but in a heterogeneous manner across individuals. These varied responses may result from unidentified gene-FOS interactions. To identify genetic factors that interact with FOS to alter the circulating levels of PUFAs, we performed a multi-level genome-wide interaction study (GWIS) of FOS on 14 plasma measurements in 200,060 unrelated European-ancestry individuals from the UK Biobank. From our single-variant tests, we identified genome-wide significant interacting SNPs (p < 5 × 10-8) in the FADS1-FADS2 gene cluster for total omega-3, omega-3%, docosapentaenoic acid (DHA), DHA%, and the omega-6 to omega-3 ratio. Among the interaction signals for omega-3%, the lead SNP, rs35473591 (C>CT, CT allele frequency = 0.34), had a lower association effect size in the FOS-taking group (β = 0.35 for …

Development Of Stem-Based Virtual Microscope Module In Fundamental Geology Course, Bigharta Bekti Susetyo, Dipo Caesario, Yulia Hanoselina, Helfia Edial, Intan Lestari Mulyaning Tyas, Ahmad Syauqi Hidayatillah, Alfyananda Kurnia Putra, Salem Amer Sayma

Jurnal Pendidikan Geografi: Kajian, Teori, dan Praktek dalam Bidang Pendidikan dan Ilmu Geografi

This research aims to develop a STEM-based virtual microscope module. It follows a 4D development model, comprising define, design, develop, and disseminate stages. Interview were employed as the primary data collection techniques. The data analysis techniques utilized both descriptive and quantitative methods. The feasibility of developed module validated by expert validators in material content, language, and learning design. Field testing was conducted with Geography Education Study Program students from Class of 2023 in the Fundamental Geology Course. The STEM-based virtual microscope module was deemed suitable for learning activities, receiving validation scores in the "good" category with minor revisions required. Student …

Creating A Positive Social-Emotional Learning Environment For Transgender Students: A Post-Pandemic Participatory Action Research, Mark Christopher Maranto

Dissertations

This qualitative research employing participatory action protocols (PAR) engages a limited number of gender minority adolescents (current transgender, nonbinary, and gender-fluid secondary students) and allied staff members at one large Midwestern public high school district. The principal purpose is to improve transgender secondary student schooling experiences. This study extends the current educational discourse on SEL (social-emotional learning) in post-pandemic high schools as far as the commitment to improving students' sense of belonging, growth mindset, resilience, and well-being should be a top priority for all educators. The primary researcher positions all participants as co-researchers to explore ways that could improve the …

In Vivo Crispr Activation Screen Identifies Acyl-Coa-Binding Protein As A Driver Of Bone Metastasis, Hongqi Teng, Qinglei Hang, Caishang Zheng, Yuelong Yan, Shaomin Liu, Yang Zhao, Yalan Deng, Litong Nie, Weiche Wu, Marisela Sheldon, Zachary Yu, Wei Shi, Jianxuan Gao, Chenling Meng, Consuelo Martinez, Jie Zhang, Fan Yao, Yutong Sun, Di Zhao, Boyi Gan, Tong Meng, Li Ma

Faculty, Staff and Student Publications

One of the most common sites of cancer metastasis is to the bone. Bone metastasis is associated with substantial morbidity and mortality, and current therapeutic interventions remain largely palliative. Metastasizing tumor cells need to reprogram their metabolic states to adapt to the nutrient environment of distant organs; however, the role and translational relevance of lipid metabolism in bone metastasis remain unclear. Here, we used an in vivo CRISPR activation screening system coupled with positive selection to identify acyl-coenzyme A (CoA) binding protein (ACBP) as a bone metastasis driver. In nonmetastatic and weakly metastatic cancer cells, overexpression of wild-type ACBP, but …

A Review Of Mirvetuximab Soravtansine-Gynx In Folate Receptor Alpha-Expressing Platinum-Resistant Ovarian Cancer, Judith A Smith, Patrick Medina, Mary Miao, Kathleen N Moore

Faculty, Staff and Student Publications

Purpose: To evaluate the pharmacology, efficacy, safety, and dosing and administration considerations (including adjusted ideal body weight [AIBW] dosing) for mirvetuximab soravtansine-gynx, a first-in-class folate receptor alpha (FRα)-directed antibody-drug conjugate for platinum-resistant ovarian cancer (PROC).

Summary: A literature search was conducted in PubMed using the terms "ovarian cancer" and "mirvetuximab soravtansine" of articles published from inception to April 16, 2024. Relevant publications, abstracts, and clinical trials were reviewed. Mirvetuximab soravtansine-gynx is dosed at 6 mg/kg AIBW every 3 weeks and comprises an FRα-binding antibody, a hydrophilic disulfide linker, and a maytansinoid DM4 payload. Mirvetuximab soravtansine-gynx binds to FRα, which induces …

Re-Envisioning Nuclear Deterrence, Raul (Pete) Pedrozo

International Law Studies

This article examines whether the U.S. nuclear umbrella provided to allies is currently viable and whether it is time for the United States to share nuclear weapons technology with its allies in the Asia-Pacific to counter the growing nuclear threat posed by China, North Korea, and Russia. The article discusses the current capabilities and nuclear doctrine of States possessing nuclear weapons, as well as Iran’s nascent nuclear weapons program. It then discusses the current international law and regulatory regime applicable to nuclear weapons. It analyzes the threats posed by China’s and Russia’s nuclear capabilities, and how they affect U.S. nuclear …

Strengthening Occupational Health And Safety (Ohs) In Schools To Minimize Risks For Students, Teachers, And Visitors: Policy Recommendation, Wiwik Eko Pertiwi, Hanifa Maher Denny, Yuliani Setyaningsih, Agung Dwi Laksono

Journal of Indonesian Health Policy and Administration

Vocational schools equip students with practical skills and expose them to industry-related hazards, making Occupational Health and Safety (OHS) a crucial aspect of the school environment. This study aims to identify key factors behind the weak implementation of OHS in vocational schools. A literature review used articles published between 2017–2024 from national and international journals. The review found poor OHS implementation stems from lack of awareness, inadequate policies, insufficient infrastructure, weak safety culture, and negligence in accident prevention. To address these issues, the study recommends OHS education and training, improvement of school infrastructure, curriculum integration, formation of safety teams, and …

Taxation Of Computer Technology, Robert L. Black, Craig E. Reese

Tax Adviser

No abstract provided.

006. Bohumil Shimek (1904-05) [Biography]

Presidents of the Iowa Academy of Science

No abstract provided.

Ph Dependent Structural Characterization Of Ich Ensembles Needed For Catalysis, Kevin C. Prososki

Honors Program: Senior Projects (Public)

No abstract provided.

Investigating The Role Of Lysophosphatidic Acid Receptor 3 In Ocular Surface Ion Transport And Fluid Secretion, Ethan Lindgren

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Dry eye disease (DED) is a multifactorial disease that drives tear film instability and hyperosmolarity, directly damaging the ocular surface epithelium. Lysophosphatidic acid receptor (LPAR) is a G-protein coupled receptor (GPCR) responsible for Ca²⁺ and cAMP mobilization via PLC and adenylyl cyclase activation, respectively. LPAR signaling is involved in cell proliferation and wound healing in human corneal epithelial cells (HCECs) as well as in neuropathic pain. This study aims to investigate expression and functional roles of LPAR3 in ocular surface. Ocular surface potential difference (OSPD) and tear fluid volume measurements were performed in mice with topically applied LPAR modulators. …

Administering A Mitophagy Inducing Compound (Mic) To Suppress Neuropathology In A Mouse Model Of Alzheimer’S Disease, Zachary Mayeri

Natural Sciences and Mathematics | Biological Sciences Master's Theses

Despite FDA-approved amyloid-beta (Aβ) therapies in Alzheimer’s disease (AD), Tau pathology remains untreated and is closely linked to cognitive decline. Mitophagy, the process of mitochondrial degradation, is vital for maintaining neuronal health, and its dysregulation is implicated in AD. Recently, our lab identified a mitophagy inducing compound (MIC) that extends the lifespan of C. elegans. We hypothesized that MIC would significantly mitigate neuropathology in an AD mouse model. In this study, aged 3x-Tg AD mice were fed an MIC-containing diet, and immunohistochemistry (IHC) was performed on hippocampal tissue to visualize Aβ and phospho-Tau (pTau) lesions. While MIC had little …

Tiktok On The Clock: It Is Time To Hold Social Media Platforms Responsible For The Dangerous Content They Push To Children, Angelina Rego

The Journal of Business, Entrepreneurship & the Law

This article examines the unresolved issue of social media companies endangering children through their targeted algorithms in a world where Section 230 protects them from any consequences. Part II will provide background on harmful content, like viral challenges, plaguing social media and endangering children. In addition, Part II will present an overview of Section 230’s immunity and its very limited exceptions. Next, Part III will analyze the legislative intent behind Section 230 and its relation to the First Amendment, highlighting that protecting children aligns with the act’s original purpose. Then, Part IV will discuss the few alternative workarounds available to …

Current Status, Public Health Implications, And Potential Future Establishment Of Amblyomma Americanum, The Lone Star Tick, In Maine, Charles Lubelczyk, Molly Meagher, Curtis Bartiromo

Journal of Maine Medical Center

Introduction: Amblyomma americanum is a medically important tick species established in the southeastern United States, with populations gradually spreading northward into New England. This study aimed to evaluate the current presence, distribution, and density of A. americanum in Maine.

Methods: Surveillance efforts focused on Ixodes scapularis have been conducted by the Vector-Borne Disease Laboratory of MaineHealth Institute for Research since 1989. This surveillance uses tick flagging, examination of hunter-harvested game and trapped wild hosts for feeding ticks, and a statewide passive surveillance program. Effort focused on A. americanum surveillance began in 2019 using flagging, carbon dioxide-baited trapping, and serosurveillance (Heartland …

Passive Tick Surveillance At The University Of Maine Cooperative Extension Tick Lab: A 6 Year Retrospective, Thomas F. Rounsville, Griffin M. Dill, Ann M. Bryant, Alyssa G. Marini, Alaina C. Woods, John S. Nugent, Olivia N. Choi, James F. Dill

Journal of Maine Medical Center

Introduction: Maine has experienced a rise in tick-borne diseases over the past several decades, reflecting broader trends in the northeastern United States. Ixodes scapularis is now found statewide and is the primary vector of Borrelia burgdorferi, Anaplasma phagocytophilum, Babesia microti, Borrelia miyamotoi, and Powassan virus. Other emerging tick species pose additional threats.

Methods: The University of Maine Cooperative Extension Tick Lab conducts a public tick-testing program. Ticks submitted by the public between 2019 and 2024 were microscopically identified and tested with multiplex quantitative polymerase chain reaction and reverse transcription-quantitative polymerase chain reaction panels for known and emerging pathogens, including B. …

Ulceroglandular Tularemia In A Pediatric Patient In Maine After A Trip To Martha’S Vineyard, Calvin Schaffer, Kevin Burke, Amanda Goddard

Journal of Maine Medical Center

Introduction: Vector-borne lymphadenitis in children is uncommon. A detailed exposure and travel history can facilitate diagnosis.

Clinical Findings: The pediatric inpatient service admitted a 6-year-old patient after multiple acute care visits for right posterior auricular tenderness, erythema, and swelling.

Clinical Course: Upon admission, the patient received intravenous ceftriaxone and clindamycin for progressive suppurative lymphadenitis. After a review of the patient’s history, which included the removal of an engorged tick and recent travel to Martha’s Vineyard, Massachusetts, the treatment was transitioned to intravenous gentamicin for ulceroglandular tularemia.

Conclusions: Francisella tularensis can be transmitted via tick and deer-fly bites and should be …

Effect Of Application Time On The Efficacy Of Trichoderma Spp. To Biologically Control Sunflower Charcoal Rot, Ahmed M. Samy, Amer F. Mahmoud, Osama A. Abdalla

Sultan Qaboos University Journal For Science

Sunflower (Helianthus annuus L.) is considered as one of the most important oilseed crops in Egypt and worldwide. It is being infected with many pathogens, among these pathogens Macrophomina phaseolina (Tassi) Goid, the causal agent of charcoal rot is the most prevalent one, and responsible for severe economic losses on sunflower production. Fourteen isolates of M. phaseolina were collected from naturally infected sunflower plants. Pathogenicity tests revealed that tested isolates varied significantly in their pathogenic capabilities. But all of the tested isolates were pathogenic and incited the symptoms of pre- and post-emergence damping-off as well as symptoms of charcoal rot. …

Assessment Of The Physicochemical Properties And Antioxidant Content In A Variety Of Omani Honey Samples, Haider A. J. Al Lawati, Javad Hassanzadeh, Nafiseh Bagheri, Muadh Al Shaidi, Majid Al Amri, Hassan Talib M. Al Lawati

Sultan Qaboos University Journal For Science

Honey, a natural product with effective medicinal properties and exceptional energy content, holds a significant place in the hearts of consumers. This study evaluated the pH, free acidity, conductivity, sugar composition, and total antioxidant content of eight types of rare honey produced in Oman. Additionally, well-known types of honey such as Sidr and Sumur, along with some commercial honey samples, were studied for comparison purposes. A simple and innovative paper-based analytical device, recently developed by our group, was applied as an appropriate alternative to time-consuming chromatography-based methods. The findings revealed a low sugar content in a type of honey called …

Ion-Dna Interactions As A Key Determinant Of Uracil Dna Glycosylase Activity., Sharon N Greenwood, Alexis N Dispensa, Matthew Wang, Justin R Bauer, Timothy D Vaden, Zhiwei Liu, Brian P Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Because of their ubiquitous presence, ions interact with numerous macromolecules in the cell and affect critical biological processes. Here, we discuss how cations including Mg²⁺ alter the enzymatic activity of a DNA glycosylase by tuning its affinity for DNA. The response of uracil DNA glycosylase (UNG2) to Mg²⁺ ions in solution is biphasic and paradoxical, where low concentrations of the ion stimulate the enzyme, but high concentrations inhibit the enzyme. We analyzed this phenomenon by modeling experimental data with a statistical framework that we empirically derived to understand molecular systems that display biphasic behaviors. Parameters from our statistical …

Ciccolella, Peg Oral History Interview, Margaret E. Ciccolella, Gene Pearson

Emeriti Society Oral History Collection

Peg Ciccolella (1985-2024) Professor of Health and Exercise Science.

Health and Exercise Science program development and change, Pacific Legal Scholars program development, chairing of and involvement in Pacific committees, chairing of health and exercise science department, the law and application to health sciences, research and publishing at Pacific, WASC accreditation, change and application of Title IX.

Student Perceptions Of The Use Of Onenote To Create A Capstone Project In A Teacher Education Program, Carmen Pena

Teaching and Learning Faculty Publications

During the Fall 2023 semester, a group of students in their first semester of the elementary education program at The University of Texas Rio Grande Valley (UTRGV) was required to use OneNote to complete a Community Case Study, which is a capstone project in the teacher education program at UTRGV. The projectconsists of three sections, which include a study of the school and district, visits to area attractions in the community, interviews with members of the community, and a final reflection on the project. The Community Case Study includes text-based files,graphics, and video. The authors used OneNote to have students …

Addition Of Biochar To Anaerobic Digestion Of Food Waste In A Uasb Reactor To Enhance Biogas Production, Michell Ortiz, Farid . Chejne, Andrea . Tamayo, Juan-Diego Otalora

Bio-Char IV

Please click Additional Files below to see the full abstract