Digital Commons Network^™

Multicomponent Parenteral Lipid Emulsions Do Not Prevent Liver Injury In Neonatal Pigs With Obstructive Cholestasis, Greg Guthrie, Caitlin Vonderohe, Valeria Meléndez Hebib, Barbara Stoll, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Biliary atresia (BA) is a pediatric liver disease that often necessitates parenteral nutrition (PN) to support growth due to impaired liver function. While soy-based lipid emulsions (SLE) are commonly used in PN, they may contribute to cholestatic liver injury. In contrast, mixed lipid emulsions (MLE) show promise in preventing cholestasis in infants without BA, potentially by restoring bile flow. However, their effectiveness in patients of complete bile duct obstruction, as seen in BA, remains uncertain. To explore the potential benefits of MLE in BA, we utilized a neonatal pig model of bile duct ligation (BDL). Pigs underwent either BDL or …

Post-Recovery Viral Shedding Shapes Wastewater-Based Epidemiological Inferences, Tin Phan, Samantha Brozak, Bruce Pell, Stanca M Ciupe, Ruian Ke, Ruy M Ribeiro, Anna Gitter, Kristina D Mena, Alan S Perelson, Yang Kuang, Fuqing Wu

Faculty, Staff and Student Publications

Background: The prolonged viral shedding from the gastrointestinal tract is well documented for numerous pathogens, including SARS-CoV-2. However, the impact of prolonged viral shedding on epidemiological inferences using wastewater data is not yet fully understood.

Methods: To gain a better understanding of this phenomenon at the population level, we extended a wastewater-based modeling framework that integrates viral shedding dynamics, viral load data in wastewater, case report data, and an epidemic model.

Results: Our results indicate that as an outbreak progresses, the viral load from recovered individuals gradually becomes predominant, surpassing that from the infectious population. This phenomenon leads to a …

Teachers’ Perspectives On The Obstacles To Implementing Inquiry-Based Learning In Secondary Science Classrooms, Gabrielle Gonzales

Walden Dissertations and Doctoral Studies

The research problem for this study was that teachers are inconsistent in using inquiry-based instruction in secondary science classrooms. Guided by Vygotsky’s theory of constructivism, the purpose of this basic qualitative study was to explore teachers’ perspectives of the obstacles to implementing inquiry-based instruction in secondary science classrooms and what they believe will be needed to allow them to overcome these obstacles. Semistructured interviews were conducted with 10 certified, current Grade 8 to 12 teachers within the United States who had experience and familiarity with inquiry-based instruction. The data were analyzed through thematic analysis with open coding. The five themes …

Commencement, Philadelphia (2025), Philadelphia College Of Osteopathic Medicine

Commencements

Philadelphia Campus Commencement Program, 2025. Degrees include Doctor of Osteopathic Medicine, Doctor of Philosophy in Educational Psychology, Doctor of Psychology in Clinical Psychology, Doctor of Psychology in School Psychology, Educational Specialist in School Psychology, Master of Science in Applied Behavioral Analysis, Master of Science in Applied Positive Psychology, Master of Science in Mental Health Counseling, Master of Science in Biomedical Sciences, Master of Science in Forensic Medicine, Master of Science in Health Sciences - Physician Assistant Studies.

Commencement Speaker: John J. Lynch III.

Decoding Resistance To Immune Checkpoint Inhibitors In Non-Small Cell Lung Cancer: A Comprehensive Analysis Of Plasma Proteomics And Therapeutic Implications, Michal Harel, Nili Dahan, Coren Lahav, Eyal Jacob, Yehonatan Elon, Igor Puzanov, Ronan J. Kelly, Yuval Shaked, Raya Leibowitz, David P. Carbone, David R. Gandara, Adam P. Dicker

Department of Radiation Oncology Faculty Papers

BACKGROUND: Immune checkpoint inhibitors (ICIs) have shown substantial benefit for patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a major clinical challenge. Here, we perform a comprehensive bioinformatic analysis of plasma proteomic profiles to explore the underlying biology of treatment resistance in NSCLC.

METHODS: The analysis was performed on 388 "resistance-associated proteins" (RAPs) that were previously described as pretreatment plasma proteomic predictors within the PROphet computational model designed to predict ICI clinical benefit in NSCLC. Putative tissue origins of the RAPs were explored using publicly available datasets. Enrichment analyses were performed to investigate RAP-related biological …

A Resource-Based Perspective Of Stem Career Development: A Latent Class Analysis, Erika Ann Schemmel

Dissertations and Theses

Through technological developments and the growing concerns around climate change, the need and demand for electric vehicles has been steadily increasing. A trained and qualified STEM workforce is required to meet these demands, yet standard STEM education may not be sufficient. The STEM development program centered in the present study is a collegiate workforce development program that provides North American students with training and hands-on experience in the engineering of electric vehicles. Drawing from central principles of COR theory, the present study explores the experiences of students within the program utilizing a resource-based perspective and a mixed-methods approach. First, the …

Integrative Computational Modeling Of Distinct Binding Mechanisms For Broadly Neutralizing Antibodies Targeting Sars-Cov-2 Spike Omicron Variants: Balance Of Evolutionary And Dynamic Adaptability In Shaping Molecular Determinants Of Immune Escape, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

In this study, we conducted a comprehensive analysis of the interactions between the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein and four neutralizing antibodies—S309, S304, CYFN1006, and VIR-7229. Using integrative computational modeling that combined all-atom molecular dynamics (MD) simulations, mutational scanning, and MM-GBSA binding free energy calculations, we elucidated the structural, energetic, and dynamic determinants of antibody binding. Our findings reveal distinct dynamic binding mechanisms and evolutionary adaptation driving the broad neutralization effect of these antibodies. We show that S309 targets conserved residues near the ACE2 interface, leveraging synergistic van der Waals and electrostatic interactions, while S304 focuses on …

Current Paradigm And Futuristic Vision On New-Onset Diabetes And Pancreatic Cancer Research, Russell Moreland Iii, Abigail Arredondo, Anupam Dhasmana, Swati Dhasmana, Shabia Shabir, Asfia Siddiqua, Bonny Bannerjee, Murali Yallapu, Stephen Behrman, Subhash Chauhan, Sheema Khan

School of Medicine Publications

New-onset diabetes (NOD) has emerged as a potential early indicator of pancreatic cancer (PC), necessitating a refined clinical approach for risk assessment and early detection. This study discusses critical gaps in understanding the NOD-PC relationship and proposes a multifaceted approach to enhance early detection and risk assessment. We present a comprehensive clinical workflow for evaluating NOD patients, incorporating biomarker discovery, genetic screening, and AI-driven imaging to improve PC risk stratification. While existing models consider metabolic factors, they often overlook germline genetic predispositions that may influence disease development. We propose integrating germline genetic testing to identify individuals carrying pathogenic variants in …

Comprehensive Evaluation Of Phosphoproteomic-Based Kinase Activity Inference, Sophia Müller-Dott, Eric J Jaehnig, Khoi Pham Munchic, Wen Jiang, Tomer M Yaron-Barir, Sara R Savage, Martin Garrido-Rodriguez, Jared L Johnson, Alessandro Lussana, Evangelia Petsalaki, Jonathan T Lei, Aurelien Dugourd, Karsten Krug, Lewis C Cantley, D R Mani, Bing Zhang, Julio Saez-Rodriguez

Faculty, Staff and Students Publications

Kinases regulate cellular processes and are essential for understanding cellular function and disease. To investigate the regulatory state of a kinase, numerous methods have been developed to infer kinase activities from phosphoproteomics data using kinase-substrate libraries. However, few phosphorylation sites can be attributed to an upstream kinase in these libraries, limiting the scope of kinase activity inference. Moreover, inferred activities vary across methods, necessitating evaluation for accurate interpretation. Here, we present benchmarKIN, an R package enabling comprehensive evaluation of kinase activity inference methods. Alongside classical perturbation experiments, benchmarKIN introduces a tumor-based benchmarking approach utilizing multi-omics data to identify highly active …

Subcortical Correlates Of Consciousness With Human Single Neuron Recordings, Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir, Jacob E Suffridge, Kaylee Tran, Shuo Wang, Victor Finomore, Peter Konrad, Ali Rezai, Olaf Blanke

2020-Current year OA Pubs

Subcortical brain structures such as the subthalamic nucleus or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness remains unclear, due to the inherent difficulties of recording subcortical neuronal activity in humans. Here, we asked neurological patients undergoing surgery for deep brain stimulation to detect weak vibrotactile stimuli applied on their hand while recording single neuron activity from the tip of a microelectrode. We isolated putative single neurons in the subthalamic nucleus and thalamus. A significant proportion of neurons modulated their activity while participants were expecting a stimulus. We found that the firing …

The Perk/Atf4 Pathway Is Required For Metabolic Reprogramming And Progressive Lung Fibrosis, Jyotsana Pandey, Jennifer L Larson-Casey, Mallikarjun H Patil, Chao He, Nisarat Pinthong, A Brent Carter

Faculty, Staff and Students Publications

Asbestosis is a prototypical type of fibrosis that is progressive and does not resolve. ER stress is increased in multiple cell types that contribute to fibrosis; however, the mechanism(s) by which ER stress in lung macrophages contributes to fibrosis is poorly understood. Here, we show that ER stress resulted in protein kinase RNA-like ER kinase (PERK; Eif2ak3) activation in humans with asbestosis. Similar results were seen in asbestos-injured mice. Mice harboring a conditional deletion of Eif2ak3 were protected from fibrosis. Lung macrophages from asbestosis individuals had evidence of metabolic reprogramming to fatty acid oxidation (FAO). Eif2ak3fl/fl mice had increased oxygen …

A Cross-Sectional Study Of The Role Of Epithelial Cell Injury In Kidney Transplant Outcomes, Philip F. Halloran, Tarek Alhamad, Et Al.

2020-Current year OA Pubs

BACKGROUND: Expression of acute kidney injury-associated (AKI-associated) transcripts in kidney transplants may reflect recent injury and accumulation of epithelial cells in "failed repair" states. We hypothesized that the phenomenon of failed repair could be associated with deterioration and failure in kidney transplants.

METHODS: We defined injury-induced transcriptome states in 4,502 kidney transplant biopsies injury-induced gene sets and classifiers previously developed in transplants.

RESULTS: In principal component analysis (PCA), PC1 correlated with both acute and chronic kidney injury and related inflammation and PC2 with time posttransplant. Positive PC3 was a dimension that correlated with epithelial remodeling pathways and anticorrelated with inflammation. …

Predicting Seizure Onset Zones From Interictal Intracranial Eeg Using Functional Connectivity And Machine Learning, Jared Pilet, Scott A. Beardsley, Chad Carlson, Christopher T. Anderson, Candida Ustine, Sean Lew, Wade Mueller, Manoj Raghavan

Biomedical Engineering Faculty Research and Publications

Functional connectivity (FC) analyses of intracranial EEG (iEEG) signals can potentially improve the mapping of epileptic networks in drug-resistant focal epilepsy. However, it remains unclear whether FC-based metrics provide additional value beyond established epilepsy biomarkers such as epileptic spikes and high-frequency oscillations (HFOs). Using interictal iEEG data from 26 patients, we estimated FC across eight frequency bands (4–290 Hz) using amplitude envelope correlation (AEC) and phase locking value (PLV). From the resulting FC-matrices, we estimated two graph metrics each to derive 32 FC-based features. We also extracted features related to spikes, HFOs, and power spectral densities (PSD). A trained support …

A Checklist Of Illinois Centipedes (Chilopoda), Gerald Summers, J. A. Beatty, Nanette Magnuson

The Great Lakes Entomologist

Records for 45 centipede species occurring in Illinois are given with a brief discussion of general habitat features and the effects of certain environmental factors on specific distribution patterns. The chilopod fauna of Illinois includes species from southeastern, western, and northern physiographic regions and represents a richer mixture of chilopod species than is found in any adjacent state.

Description And Biology Of Bumblebees (Hymenoptera: Apidae) In Michigan, Robert W. Husband, Roland L. Fischer, T. Wayne Porter

The Great Lakes Entomologist

The distribution of Michigan Bombinae was first studied by Milliron (1939). Records of Michigan bumblebees were included in Cockerell (1916) Franklin (1912). Lutz and Cockerell (1920). and Mitchell (1962). Other major studies in the Great Lakes Region were Chandler (1950) for Indiana, Medler and Carney (1%3) for Wisconsin, Husband (1966) for Michigan, Macfarlane (1974) for Ontario, LaBerge and Webb (1962) for Nebraska, Stevens (1948) for North Dakota, Frison (1926) for Illinois, and Neave (1933) for Manitoba. The purpose of this paper is to add to the information presented by Milliron (1939) and to complement the works by Chandler, Medler and …

The Biology Of The White Pine Sawfly, Neodiprion Pinetum (Hymenoptera: Diprionidae) In Wisconsin, Aunu Rauf, D. M. Benjamin

The Great Lakes Entomologist

The white pine sawfly, Neodiprion pirletunl. is monophagous on eastern white pine, Pinus strobus, throughout its range in eastern North America. Localized outbreaks occur frequently, and small areas of white pine may be killed. The high population upsurge in Crawford County. Wisconsin, in 1978 was mitigated by the eulophid egg parasite, Closterocerus cinctipennis, when a mean 90.1 t 4.870 parasitization occurred. Larval parasitization in the Grant County infestation averaged 45.05%. and involved the ichneumonid, Olesicampe lophyri, the perilampid Perilamplts l~yalirllcs, and the tachinid Spathimeigenia erecta.

Observations On The Biology Of The Slender Seedcorn Beetle, Clivina Impressifrons (Coleoptera: Carabidae), Robert D. Pausch, Lois M. Pausch

The Great Lakes Entomologist

The slender seedcorn beetle, Clirina impressijirons, is known to attack germinating corn seed, but field and laboratory studies of its life history indicate it may sometimes play a beneficial role. Feeding studies show that adults and larvae are primarily carnivorous but will feed on corn seed when their primary food is absent or in short supply. Certain behavioral aspects indicate that populations of this beetle might be attracted to selected agricultural areas where adults and larvae could serve as predators of soil pests of corn. Much of the activity of these beetles is governed by temperature. with low temperatures below …

Mixed Species Feeding Assemblages Of Planthopper Nymphs (Homoptera: Fulgoroidea), S. W. Wilson, J. E. Mcpherson

The Great Lakes Entomologist

The occurrence of four species of southern Illinois fulgoroids in mixed species feeding assemblages is reported.

Seasonal Flight Patterns Of Hemiptera In A North Carolina Black Walnut Plantation. 1. Pentatomoidea, J. E. Mcpherson, B. C. Weber

The Great Lakes Entomologist

The seasonal flight patterns of 35 species and subspecies of Pentatomoidea collected in window traps in a North Carolina black walnut plantation are discussed. Flying height distributions and seasonal activities of the five species that were most frequently collected (i.e., Amnestus basidentatus, A. pallidus, A. spinifrons, Brochymena qltadripustulata and Euschistus servus) are considered in detail.

Navigating Difficult Conversations And Recognizing Persons Of Concerns: Confrontation, De-Escalation, And Threat Awareness, Mike Zegadlo

May Institute

A student angry about their grade, a peer not pulling their weight, a supervisor sharing criticism; all can trigger anxiety and stress. Human beings experience physiological responses to stressful encounters that inhibit our ability to communicate, problem solve and listen when it’s most important to do so. Targeted attacks, like active shooters incidents, are not spontaneous, sudden events which occur without warning. They are predictable and, consequently, preventable. Students, co-workers or others may exhibit risk factors or observable behaviors that would indicate they may be on the “pathway to violence.”

In this interactive presentation, participants will be introduced to methods …

State Legislatures And Trans* Genocide (?) In The United States, Shannon Fyfe

Tennessee Journal of Race, Gender, & Social Justice

No abstract provided.

A Rare Case Of Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Dominic Marcus Do, Richarchito Manera Md

Scientific Day

No abstract provided.

Prolonged Symptom Relief From Symphysis Pubis Dysfunction (Aka Lightning Crotch) With Chiropractic Treatment For Low Back Pain, Camila L. Irizarry Porrata Dc, Eric Kirk Dc, Daco, Jessy Johnson Dc, Venkateswara Gogineni Phd

Scientific Day

No abstract provided.

Navigating Difficult Conversations And Recognizing Persons Of Concerns: Confrontation, De-Escalation, And Threat Awareness, Mike Zegadlo

May Institute

A student angry about their grade, a peer not pulling their weight, a supervisor sharing criticism; all can trigger anxiety and stress. Human beings experience physiological responses to stressful encounters that inhibit our ability to communicate, problem solve and listen when it’s most important to do so. Targeted attacks, like active shooters incidents, are not spontaneous, sudden events which occur without warning. They are predictable and, consequently, preventable. Students, co-workers or others may exhibit risk factors or observable behaviors that would indicate they may be on the “pathway to violence.”

In this interactive presentation, participants will be introduced to methods …

Determination Of Residues Of Organochlorine In Meat Products In Sultanate Of Oman Markets By Gas Chromatography/Mass Spectrometry And Enzyme-Linked Immunosorbent Assay, Khdija S. Al-Hosni, Isam T. Kadim, Sausan S. Al-Yaqoobi, Samia A. Al-Riyami, Reem M. Al-Abri

Sultan Qaboos University Journal For Science

Meat and meat products are good sources of nutrients and play an essential role in consumer health. Therefore, meat safety is one of the main concerns for humans today. Consumers around the world might be exposed to harmful materials due to ingesting contaminated meat products. The present investigation compared three analytical methods for the determination of pesticides 2,4-D (2,4-1) dichlorophenoxyacetic acid), dichlorodiphenyldichloroethylene/dichlorodiphenyltrichloroethane, alachlor, and organophosphates) residues in 145 beef, sheep, goat, chicken and turkey species meat samples (fresh, frozen meats, meatball, mortadella, and sausage samples) of local, regional, and international brands available in Omani markets. The results revealed that the …

Analysis Of Heavy Metal Pollution In E-Waste Dumpsites From Two Local Government Areas In Ogun State, South Western Nigeria, Adetoro T. Talabi, Timothy W. David, Abayomi E. Ajetunmobi, Rasaki K. Odunaike, Shamsideen K. Alausa

Sultan Qaboos University Journal For Science

Dumping sites in general have been noted to be sources of pollution in the environment and e-waste dumping sites are not exempted. A study on the pollution of heavy metals in two local government areas (LGAs) in Ogun State, was investigated. As, Cd, Co, Cr, Cu, Fe, Ni, Pb, and Zn were detected. Cd, Cu were detected in two areas. While Fe, Pb in four areas, and Zn concentrations were above the World Health Organisation permissible limit. Analysis indicates that the contaminant factor (CF) varies from low to severe at both LGAs; however, CF of Cd is severe in all …

The Menstrual Cycle And Relationships, Anna Stewart

Family Perspectives

No abstract provided.

Pilot Study Of Canakinumab (Ilaris) In Steroid Naïve Children With Duchenne Muscular Dystrophy Demonstrates Safety And Exploratory Changes In Potential Serum Protein Response Biomarkers, Christopher F. Spurney, Jessica Chong, Heather Gordish-Dressman, Yetrib Hathout

Pharmacy Faculty Scholarship

Background: Duchenne muscular dystrophy (DMD) is a progressive muscular disease associated with muscle fiber degeneration and increased inflammatory responses including Interleukin-1 beta (IL-1β) and other cytokines. Canakinumab (Ilaris) is an anti-human IL-1β monoclonal antibody that neutralizes IL-1β. Methods: We completed an open-label, single dose pilot study of canakinumab 2 mg/kg subcutaneous injection in steroid naïve boys with DMD older than 2 years of age to determine safety and potential serum response biomarkers of efficacy at 4-weeks post treatment. Proteome profiling was performed using high throughput multiplexing aptamer SomaScan assay based technology targeting 1,500 unique serum proteins. Results: Three subjects completed …

Commencement: Conferral Of Baccalaureate Degrees May 21, 2025, New Jersey Institute Of Technology

Commencement Programs

Program for the commencement conferral of Baccalaureate degrees. The ceremony took place on Wednesday, May 21, 2025.

Characterization Of Immunogenicity Of Hiv Mrna Vaccine In Humanized Mice, Omoyeni Precious Adejare

Biotechnology Theses

Human Immunodeficiency Virus (HIV) remains a leading global cause of mortality. Despite decades of research, a definitive cure or an effective vaccine for HIV infection has yet to be discovered. The major target for HIV vaccine development is the envelope (Env) trimeric protein that is responsible for host cell attachment and fusion. This comprises gp120 and the transmembrane gp41. Gp140, a truncated form of gp160(full envelope trimer) lacks the transmembrane and cytoplasmic domains of gp41, closely mimics the native HIV envelope has been shown to enhance the induction of broadly neutralizing antibodies (BnAbs) when used as protein vaccine in previous …