Digital Commons Network^™

Computational Approach: 3d-Qsar, Molecular Docking, Molecular Dynamics Simulation Investigations, Drug- Like-Ness, And Dft Score Evaluation Of A Potential Novel And Retrosynthesis Of Some Tr-H Derivatives As Streptococcus Pneumoniae Drug., Belaidi Mustapha, Tchouar Noureddine, Djelilate Mohammed, Saleh Bufarwa, Dalal K. Thbayh

Karbala International Journal of Modern Science

Streptococcus pneumoniae is the main source of hospital-acquired pneumonia and meningococcal pneumonia in children, adults, and the elderly, especially the immunocompromised. Recently, it has attracted the attention of many research studies around the world as a potential target for remediation. TR-H are considered SP antibacterial agents, as they can inhibit. To describe their mode of action and to identify new antibacterial drugs against Streptococcus pneumoniae exhibiting the TR-H scaffold, the present work included 3D-QSAR, in- silico pharmacokinetic evaluation and molecular simulation modelling of TR-H. Using an atom-based method for quantitative structure-activity relationship (QSAR) study, a comprehensive 3D-QSAR model …

Potential Economic Impact Of Grapevine Phylloxera (Hemiptera: Phylloxeridae) On Western Australian Winegrapes, David C. Cook, Andrew S. Taylor, Peter S. Gardiner, Rodrigo Pires, Hamish L R Mckirdy, Karen W. Holmes, Helen Spafford

Viticulture Research Articles

Grapevine phylloxera Daktulosphaira vitifoliae Fitch (Hemiptera: Phylloxeridae) has been present in Australia for almost 150 years but has not spread to south-west Western Australia, in part due to the relative isolation of the region. Recent improvements in tourist access, with interstate flights now arriving at Busselton Margaret River Airport, raise concerns about potential phylloxera introductions via wine tourism. In this paper, we simulate the potential economic impact on the Western Australian winegrape industry following a hypothetical arrival event in the Margaret River wine region. We use soil texture maps to assess the suitability of winegrape-growing areas to phylloxera establishment and …

Skin Cancer Diagnosis Utilizing Hybrid Discrete Cosine Transform And High-Performance Convolutional Neural Networks, Mohammed M. Abo-Zahhad, Mohammed Abo-Zahhad

Mansoura Engineering Journal

Detecting skin cancer early and accurately is crucial for successfully treating this potentially fatal disease. Enhancing the accuracy of visual inspection techniques is often necessary to improve clinical decision-making and increase the chance of successful treatment outcomes. In this research, high-performance deep learning (DL) models for automated skin cancer categorization and early skin cancer diagnosis screening are developed and evaluated in conjunction with the discrete cosine transform (DCT). For this purpose, features are extracted from medical images using both techniques. The DCT is used for feature extraction and dimensionality reduction, while deep learning (DL) trains fully connected models for classification …

M6a Modification Is Incorporated Into Bacterial Mrna Without Specific Functional Benefit, Klara Szydlo, Leonardo Santos, Thomas W. Christian, Sunita Maharjan, Amir Dorsey, Isao Masuda, Jingxuan Jia, Yuan Wu, Weixin Tang, Ya-Ming Hou, Zoya Ignatova

Department of Biochemistry and Molecular Biology Faculty Papers

N 6-Methyladenosine (m6A), the most abundant modification in eukaryotic messenger RNAs (mRNAs), has also been found at a low level in bacterial mRNAs. However, enzyme(s) that introduce m6A modification on mRNAs in bacteria remain elusive. In this work, we combine deep-sequencing approaches that identify m6A sites with in vitro biochemical studies to identify putative m6A methyltransferases that would modify Escherichia coli mRNAs. We tested four uncharacterized candidates predicted to encode proteins with putative methyltransferase domains, whose deletion decreased the m6A level. However, in vitro analysis with the purified putative methyltransferases revealed that none of them installs m6A on mRNA. Exposure …

Dynamate: Leveraging Ai-Agents For Customized Research Workflows, Orlando A. Mendible-Barreto, Misael Díaz-Maldonado, Fernando J. Carmona Esteva, J. Emmanuel Torres, Ubaldo M. Córdova-Figueroa, Yamil J. Colón

Computer and Data Science Faculty Publications

No abstract provided.

Exploring Cellulose Pyrolysis Mechanisms And Biochar Formation Through Reactive Molecular Dynamics And Dip Ft-Icr Ms, Valentina Sierra, Théo Voellinger, Vincent Carré, Farid Chejne, Sébastien Schramm, Frédéric Aubriet, Manuel Garcia-Perez

Bio-Char IV

Please click Additional Files below to see the full abstract

Structural Covariance And Episodic Memory: Sex Differences In Schizophrenia, Delaina Brooke Cimmino

Theses and Dissertations

Schizophrenia (SCZ) is a chronic brain disease characterized by patterns of positive, negative, and cognitive symptoms that interfere with daily functioning and persist throughout the lifespan. Clinical and cognitive symptoms differ between males and females with the disease, suggesting neurobiological abnormalities that vary on the basis of biological sex. The present study used high-dimensional brain mapping and network analysis procedures of cortical and limbic regions known to be involved in memory formation to investigate sex differences in brain correlates of episodic memory among patients with schizophrenia. This study analyzed multi-site archival data from 363 male (M) and 108 female (F) …

Educational Policy Committee Meeting – Open Session Book 05/22/2025, Uc Law Sf

2025 Board of Directors Agenda and Materials

No abstract provided.

Conformational Change In A Four-Tetrad Dna G-Quadruplex Upon Intercalation Of A Small-Molecule Ligand Pydh2, Kailey N. Martin, Gwendolyn Lam , '24, O. Reznichenko, K. E. Brunner, M. J. Zdilla, Sawyer E. Mccarthy, Liliya A. Yatsunyk

Chemistry & Biochemistry Faculty Works

G-quadruplexes (G4s) are non-canonical DNA structures implicated in a number of biological processes. Small-molecule ligands can alter stability and folding of G4s, which can potentially be exploited for therapeutic purposes. In this work, we investigate the interaction of telomeric DNA fragment from Tetrahymena thermophila (TET25, 5′-G(TTGGGG)₄-3′) with a G4 ligand PyDH2 belonging to the bisquinolinium family. When alone, TET25 adopts a mixture of three conformations, with the most abundant being a four-tetrad hybrid G4. In the presence of PyDH2, surprisingly, TET25 folds into an antiparallel chair G4, with PyDH2 intercalated between G-tetrads 2 and 3, according to our crystal structure. …

Improving Patients' Confidence In Self-Care Management And Preventing Hospital Readmission Within 30 Days Of Discharge In The Heart Failure Population, Kelly Carroll

Doctor of Nursing Practice Final Manuscripts

Abstract

Background: Heart failure (HF) is a chronic, progressive condition and a leading cause of hospital admissions nationwide. The 30-day readmission rate for HF patients is approximately 23.4%, contributing to increased morbidity, mortality, and significant healthcare costs. Each HF-related readmission is estimated to result in a financial loss of $15,789 per patient due to reduced reimbursement from both private and public insurers. This underscores the critical need for timely follow-up care, particularly within the first 30 days post-discharge.Without adequate follow-up and patient education, many individuals lack the confidence and knowledge necessary for safe and effective self-management in the outpatient setting, …

Policy Proposal For Integrating Pediatric Mental Health Into Nursing Practice In Uganda, Giselle S. Perez

Doctor of Nursing Practice Final Manuscripts

Abstract

Background: Mental health disorders affect over 1 in 7 individuals aged 10 to 19 globally. In low- and middle-income countries like Uganda, limited access to mental health specialists and pervasive stigma exacerbate the gap in care. Nurses, often the first point of contact, typically lack adequate pediatric mental health training. The proposal aims to address this gap by equipping nurses with the knowledge and competencies to identify, intervene, and support children with mental health disorders. Purpose: This proposal advocates for implementing targeted, continuing education in pediatric mental health for Ugandan nurses. The goal is to enhance the quality of …

From Fee For Service To Outcome Based Care: A Policy Proposal To Reduce Provider Burnout In Assertive Community Treatment, Amanda M. Thompson

Doctor of Nursing Practice Final Manuscripts

Purpose: This project examines the impact of the fee-for-service (FFS) reimbursement models on provider burnout within Assertive Community Treatment (ACT) programs and proposes a hybrid reimbursement framework that integrates case-rate and outcome-based payment structures. The goal is to enhance care quality, improve provider retention and optimize patient outcomes by addressing financial and administrative inefficiencies inherent in the current model.

Background: Mental illness affects over 59 million U.S. adults with serious mental illness (SMI) presenting significant challenges in healthcare delivery. ACT is an evidence-based, multidisciplinary approach designed to provide intensive, community-based psychiatric care to individuals with serious mental illness (SMI). However, …

Sexual And Vegetative Recruitment Of Trembling Aspen Following A High-Severity Boreal Wildfire, Denyse A. Dawe, Ellen Whitman, Michael Michaelian, Alan J. Tepley, Marc-André Parisien

Aspen Bibliography

Background High-severity fire is rare in trembling aspen-dominated forests of the boreal region. The post-fire recruitment strategy of aspen, by either vegetative suckering or sexually (i.e., by seed), has considerable implications for subsequent forest structure, genetic diversity, and ecological resilience to shifting climatic and disturbance regimes. In this study, we take advantage of the unique opportunity provided by the Chuckegg Creek Wildfire Fire (310,000 ha) in northern Alberta, Canada, which burned at high severity through aspen stands before and after spring green-up, to document how phenology, fire severity, and stand characteristics affect recruitment one year following the fire.

Results We …

Whole Genome Sequencing Identifies Monogenic Disease In 56.1% Of Families With Early-Onset Steroid-Resistant Nephrotic Syndrome, Eman Ramadan

Pharmacy

Genetic causes of steroid-resistant-nephrotic-syndrome (SRNS) represent a rapidly growing number of monogenic diseases. The reported diagnostic yield of various studies applying genetic panels and exome-sequencing to diagnose SRNS is usually < 30%. We performed genome-sequencing in a cohort of Egyptian SRNS patients. We recruited 47 SRNS patients belonging to 41 unrelated families [28 males/19 females; median (range): 6 (0.5-22 years)]. We established a pipeline for genome sequencing, bioinformatics analysis, variant curation and protein modeling at the Egypt Center for Research and Regenerative Medicine (ECRRM). Disease-causing variants were detected in 27/47 patients (57.4%) belonging to 23/41 families (56.1%), including nine novel variants in NPHS1, NPHS2, COL4A3, MYO1E, NUP93, PLCE1, PODXL, SMARCAL1 and WT1. Novel variants were confirmed by Sanger sequencing and were segregated in families of affected patients. NPHS2 was the most common causative gene in 8/23 (34.8%) of confirmed families, followed by NPHS1, WT1, and SMARCAL1 in 2/23 families (8.7%) each. All detected missense variants were evaluated through protein modeling and were predicted deleterious. Our study expanded the spectrum of SRNS disease-causing variants and revealed a monogenic cause in 56.1% of investigated families. In our cohort, no deep intronic or regulatory variants were detected by genome-sequencing. Pursuing genetic diagnosis in SRNS patients is crucial to inform clinical decision making, genetic counseling, transplantation strategy and prenatal diagnosis thus improving clinical outcome of affected patients.

Spousal Bereavement Enhances Proinflammatory Cytokine Production To Acute, Psychological Stress., E Lydia Wu-Chung, Ryan L. Brown, Robert Suchting, Jensine Paoletti-Hatcher, Michelle A. Chen, Angie S. Leroy, Kyle W. Murdock, Cobi J. Heijnen, Christopher P. Fagundes

Psychology Faculty Publications and Presentations

Early widowhood is characterized by chronic stress and is associated with a higher risk of incident depression and cardiovascular-related morbidity and mortality. Peripheral inflammation is involved in the pathogenesis of major depressive disorder and atherothrombosis and may represent a common mechanism underlying widow(er)'s elevated risk for both health conditions. Chronic psychological stress sensitizes the release of proinflammatory cytokines during the peripheral stress response. The present study examined whether recent spousal bereavement enhances the inflammatory response to an acute, psychological stressor. Recently widowed older adults (n = 143) and non-widowed controls (n = 69) participated in a quasi-experimental study, during which …

Umn Morris Announces 2025 Student Award Winners, Communications And Marketing

Campus News Archive

No abstract provided.

The Role Of Cephalic Mechanosensory Bristles In Flight Initiation Of The Oleander Hawkmoth, Daphnis Nerii, Maitri Manjunath

Theses and Dissertations

During flight, insects sense air movement past their bodies via sensory bristles distributed all over their body. These bristles provide mechanosensory feedback to their nervous system, thereby modulating wing motion to cope with ambient wind conditions. In many insect systems including locusts, moths, etc., flight can be rapidly initiated by stimulating a set of bristles called cephalic bristles on their head. Rapid initiation of flight requires diverse, distributed flight-related reflexes to be simultaneously activated.

Thus, we hypothesized that cephalic bristles directly and simultaneously trigger diverse flight-related reflexes. We tested this hypothesis using the Oleander hawkmoth, Daphnis nerii, as our study …

Neuroanatomical And Morphometric Differences In Children Who Stutter, Mohammad A. Khan

Honors Scholar Theses

Childhood-Onset Fluency Disorder commonly known as stuttering is a neurodevelopmental speech disorder characterized by disruptions in speech fluency. While genetic and neurobiological factors are implicated, the structural brain differences underlying stuttering remain unclear. This study investigated neuroanatomical alterations in children who stutter (CWS) compared to typically fluent children (TFC), focusing on gray matter volume, cortical thickness, and surface area in speech-related regions; the Inferior Frontal Gyrus, Middle Temporal Gyrus, and Pre-motor Operculum. High-resolution MRI data from 100 children (48 CWS, 52 TFC) aged 3–12 years were analyzed using FreeSurfer. Group comparisons revealed no statistically significant differences in cortical thickness, surface …

Staff Education On Gad-7 Screening Tool Implementation, Sandra Oghomwen Osemwonta

Walden Dissertations and Doctoral Studies

As a staff educational project, I addressed a critical issue in nursing practice. In many clinical settings, medical personnel are unprepared to use screening instruments such as the Generalized Anxiety Disorder 7-Item (GAD-7) tool because they do not possess the requisite expertise, which often leads to missed or delayed identification of anxiety symptoms. Timely and accurate mental health assessments are essential for effective patient care and improved clinical outcomes. Does an educational program of a Psychiatric outpatient clinic increase staff knowledge and confidence in using the General Anxiety Disorder (GAD-7) tool, compared to baseline knowledge before training? was the central …

Stomatal Distribution And Post-Fire Recovery: Intra-And Interspecific Variation In Plants Of The Pyrogenic Florida Scrub, Genevieve Triplett, Aaron S. David

Faculty Publications

Premise

Amphistomy, the presence of stomata on both leaf surfaces, can increase photosynthesis yet is uncommon across vascular plants. The relative infrequency of amphistomy is often attributed to high costs, such as transpirational water loss. The Florida scrub—a hot, dry, shrub-dominated habitat—historically has experienced frequent fire, yet decades of anthropogenic suppression coupled with the reintroduction of prescribed burns has led to varied fire regimes. In this study, we investigated the links between amphistomy and fire with regard to the presence of the trait across species in this pyrogenic habitat and within-species variation before and after experimental fire and across a …

Engineering The Immune Response To Biomaterials, Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi

Michigan Tech Publications

Biomaterials are increasingly used as implants in the body, but they often elicit tissue reactions due to the immune system recognizing them as foreign bodies. These reactions typically involve the activation of innate immunity and the initiation of an inflammatory response, which can persist as chronic inflammation, causing implant failure. To reduce these risks, various strategies have been developed to modify the material composition, surface characteristics, or mechanical properties of biomaterials. Moreover, bioactive materials have emerged as a new class of biomaterials that can induce desirable tissue responses and form a strong bond between the implant and the host tissue. …

Effects Of Fibrogenic And Non Fibrogenic Nanomaterials On Cellular And Molecular Responses In Thp-1 Macrophage, Adedayo E. Oyerinde

Biotechnology Theses

Traditional toxicological testing of nanomaterials is often low-throughput and time-consuming. Here, we aimed to develop an economically viable in vitro assay to prescreen nanomaterials with fibrogenic potential. To this end, we tested the generation of reactive oxygen species (ROS) as well as cytokines (pro- and anti-inflammatory) by macrophages following treatment with fibrogenic and non-fibrogenic nanomaterials. Both classes of nanomaterials induced ROS indistinguishably, suggesting that ROS production doesn’t predict nanomaterial fibrogenicity. We observed higher levels of IL1β and IL6 in macrophages treated with fibrogenic nanomaterials. Analysis of single-cell RNA-Sequencing data of fibrotic lungs from rodents and humans revealed overexpression of Brain …

A Review Of Medical Ethics In Orthopaedic Surgery: Current Foci And Future Considerations, Ryan X Lam, Zhi Mei Sonia He, Ruhi Thapar, Maggie Wang, Dion G Birhiray, Matthew Milad, Lara Ouellette, Umar Ghilzai, Tucker J Cushing, M Brent Price, Brenden B Ronna, Omar H Atassi, Christopher H Perkins, John R Dawson, William M Granberry, Melvyn A Harrington, Douglas R Dirschl, Lorenzo R Deveza

Library Staff Publications

Medical ethics education is a required component of orthopaedic surgery resident training per the Accreditation Council for Graduate Medical Education (ACGME) guidelines, although no standardized curriculum currently exists.

Beyond the 4 principles of bioethics (autonomy, beneficence, nonmaleficence, justice), additional ethical concepts relevant to orthopaedic care include utilitarianism, deontology, virtue ethics, moral intuitionism, microethics, and narrative ethics.

Ethical themes identified in the literature relevant to orthopaedic surgery include the ethics involved in medical decision-making, use of new technologies, caring for vulnerable patients, performing high-stakes procedures, the impacts of trainee status on patient care, and patient attitude regarding conflict of interest.

Ethical …

Navigating Knowledge: An Autoethnographic Journey Through Instructional Decision-Making And Educational Technology Development, Daniel James Clark

Theses and Dissertations from DePaul University

Have you ever felt lost while learning? Guided by this curiosity, the researcher embarked on a decade-long journey to understand how students navigate learning environments and how educational technology might offer clearer pathways. In response, the researcher designed and developed Navigating Knowledge, a learning platform informed by his dual roles as a higher education instructor and educational technology developer. This capstone is distinct in its simultaneous integration of theory, design, and implementation to bridge pedagogical insight with technological innovation. Using an analytic autoethnographic methodology, this qualitative research critically examined 33 instructional, platform development, and reflective journal artifacts from 2013 to …

What We Think Others Think And Do About Climate Change: A Multicountry Test Of Pluralistic Ignorance And Public-Consensus Messaging, Sandra J. Geiger, Jana K. Köhler, Zenith N. C. Delabrida, Karla A. Garduño-Realivazquez, Christian A. P. Haugestad, Hirotaka Imada, Aishwarya Iyer, Carya Maharja, Daniel C. Mann, Michalina Marczak, Olivia Melville, Sari R. R. Nijssen, Nattavudh Powdthavee, Radisti A. Praptiwi, Gargi Ranade, Claudio D. Rosa, Valeria Vitale, Małgorzata Winkowska, Lei Zhang, Mathew P. White

School of Psychology

Most people believe in human-caused climate change, yet this public consensus can be collectively underestimated (pluralistic ignorance). Across two studies using primary data (n = 3,653 adult participants; 11 countries) and secondary data (ns = 60,230 and 22,496 adult participants; 55 countries), we tested (a) the generalizability of pluralistic ignorance about climate-change beliefs, (b) the effects of a public-consensus intervention on climate action, and (c) the possibility that cultural tightness-looseness might serve as a country-level predictor of pluralistic ignorance. In Study 1, people across 11 countries underestimated the prevalence of proclimate views by at least 7.5% in Indonesia (90% credible …

Biology Faculty Member Honored As Online Instructor Of The Year, Pam Starling

University of Mississippi News

OXFORD, Miss. – The University of Mississippi's Office of Academic Outreach has honored biology professor Lydia Lytal's efforts to create and lead an online laboratory science class by awarding her its Paragon Award for Excellence in Distance Teaching.

Understanding Host-Pathogen Interactions Using The Caenorhabditis Elegans – Orsay Virus Experimental Model, Chika Fujii

Arts & Sciences Graduate Student Theses and Dissertations

Over an evolutionary timeline, viruses have evolved ways to exploit biochemical pathways of the host for their propagation, whereas host organisms developed mechanisms to recognize virus infection and cope with them. Consequently, a better understanding of the different host factors involved in virus replication could provide insights into potential biological pathways or molecules for therapeutic targeting. Furthermore, detailed dissection of the mechanisms of virus sensing could reveal fundamentally important aspects of virus sensing that are evolutionarily conserved to mammals and offer insights into potentially underexplored areas of research. The C. elegans experimental model offers a useful platform for studying evolutionarily …

Cost-Effective Solutions For High-Throughput Enzymatic Dna Methylation Sequencing, Amy Longtin, Marina M. Watowich, Baptiste Sadoughi, Rachel M. Petersen, Sarah F. Brosnan, Kenneth Buetow, Qiuyin Cai, Cayo Biobank Research Unit, Vanderbilt University, Michael D. Gurven, James P. Higham, Heather M. Highland, Yi-Ting Huang, Hillard Kaplan, Thomas S. Kraft, Yvonne A. L. Lim, Jirong Long, Amanda D. Melin, Michael J. Montagne, Jamie Roberson, Kee Seong Ng, Michael L. Platt, India A. Schneider-Crease, Jonathan Stieglitz, Benjamin C. Trumble, Vivek Venkataraman, Ian J. Wallace, Jie Wu, Noah Snyder-Mackler, Angela Jones, Alexander G. Bick, Amanda J. Lea

ESI Publications

Characterizing DNA methylation patterns is important for addressing key questions in evolutionary biology, development, geroscience, and medical genomics. While costs are decreasing, whole-genome DNA methylation profiling remains prohibitively expensive for most population-scale studies, creating a need for cost-effective, reduced representation approaches (i.e., assays that rely on microarrays, enzyme digests, or sequence capture to target a subset of the genome). Most common whole genome and reduced representation techniques rely on bisulfite conversion, which can damage DNA resulting in DNA loss and sequencing biases. Enzymatic methyl sequencing (EM-seq) was recently proposed to overcome these issues, but thorough benchmarking of EM-seq combined with …

Increasing The Educational Attainment Of Youth In Extension Of Foster Care Through Positive Youth Development Centered Programming, Julia M. Rossmiller

Senior Capstone Papers

Approximately 20,000 young adults age out of the foster care system in America each year. Of these 20,000 individuals, less than one-quarter will choose to participate in Extension of Foster Care services. Even fewer will complete a bachelor’s degree by age 26. Extension of Foster Care provides financial support for housing and education for young adults pursuing an education or working. However, most young adults have received little or no education on post-secondary options despite having the financial resources available for these programs. Low levels of protective factors further raise the barrier to entry for young adults to pursue an …

Corradjust Unveils Biologically Relevant Transcriptomic Correlations By Efficiently Eliminating Hidden Confounders, Stepan Nersisyan, Phillipe Loher, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

Correcting for confounding variables is often overlooked when computing RNA-RNA correlations, even though it can profoundly affect results. We introduce CorrAdjust, a method for identifying and correcting such hidden confounders. CorrAdjust selects a subset of principal components to residualize from expression data by maximizing the enrichment of "reference pairs" among highly correlated RNA-RNA pairs. Unlike traditional machine learning metrics, this novel enrichment-based metric is specifically designed to evaluate correlation data and provides valuable RNA-level interpretability. CorrAdjust outperforms current state-of-the-art methods when evaluated on 25 063 human RNA-seq datasets from The Cancer Genome Atlas, the Genotype-Tissue Expression project, and the Geuvadis …