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Investigation Into Thermodynamic And Kinetic Phenomena In Arylation Reactions With Diaryliodonium Salts, Soocheta Jha

Dissertations and Theses

Benzenoid rings are fundamental structural motifs in organic chemistry, widely recognized for their prevalence in natural products, pharmaceuticals, agrochemicals, and functional materials. Transition metal-catalyzed arylation, using catalysts such as palladium, nickel, or copper, has revolutionized C-C, C-O, and C-N bond formation, offering broad substrate scope and high efficiency. Among the reagents developed for efficient aryl group transfer, diaryliodonium salts have emerged as particularly powerful tools. Diaryliodonium salts facilitate metal-free arylations across a broad spectrum of nucleophiles, offering high reactivity, operational simplicity and environmental compatibility. The versatility of diaryliodonium salts has led to their widespread adoption as efficient arylating reagent in …

Association Between Microsatellite Loci And Body Weight Over Generations Of Selection For Growth In Local Selected Chicken Lines, Mariam S. Orabi, Essam A. El-Gendy, Ahmed M. El-Kaiaty, Ellham H. Abbas, Marwa M. Ahmed, Mostafa M. Helal

Turkish Journal of Veterinary & Animal Sciences

The genetic improvement of local chicken breeds is essential for sustainability and adaptability. Marker-assisted breeding can increase the response to selection; however, it requires the identification of marker associations with different traits. Therefore, the current study aimed to evaluate the association between microsatellite marker alleles and the body weight of juvenile chicks over three subsequent generations. Ten microsatellites were used to genotype four chicken lines (two selected and two randombred) across three generations. The lines included the normally feathered selected line (CE1), the normally feathered randombred line (CE2) used as a genetic control for CE1, the naked-neck selected line (CE3), …

Phylogenetic Insights Into Three Turkish Native Sheep Breeds Through Microsatellite Analysis, Mesut Yildirir, Tülay Canatan, Nezi̇h Ata, Zuhal Gündüz, Emre Alarslan, Yasemi̇n Öner, Onur Yilmaz

Turkish Journal of Veterinary & Animal Sciences

Animal genetic resources are recognized as an indispensable component of humanity’s natural heritage and are essential for ensuring environmental sustainability for future generations. The aim of this study was to investigate the genetic diversity, population structure, and presence of genetic bottlenecks in three indigenous Turkish sheep breeds: Dağlıç, Karagül, and Sakız, all of which are conserved as genetic resources in Türkiye. Genomic DNA was extracted from 140 blood samples using the salt precipitation technique. These samples were collected from the Sakız (n = 53), Dağlıç (n = 58), and Karagül (n = 29) breeds, which were reared on 13 farms …

Histological And Histochemical Study Of The Salt Glands In Geese (Anser Anser): Are There Receptor Cells In Salt Glands?, Şahi̇n Aslan, Di̇lem Gülece Ermutlu, Serap İlhan Aksu, Serap Koral Taşçi, Turgay Deprem

Turkish Journal of Veterinary & Animal Sciences

The regulation of solutes occurs not through the skin but via salt glands located in the nose and kidneys in reptiles and birds. This study aimed to investigate and elucidate the histological structure of the salt glands in domestic geese, and to characterize their ducts and cellular components in detail.Crossmon’s triple staining technique, hematoxylin and eosin (H&E), periodic acid-Schiff (PAS), combined alcian blue, and Kluver– Barrera stains were used for the histological investigations.The outer surface of the organ was enclosed by connective tissue, and the capsule subdivided the tissue into bulbs. Nerve fibers and endings were observed within the capsule …

The Effects Of Fcs And Cysteamine On The Freezing Of Kıvırcık Ram Semen, Eli̇f Merve Çinar, Hati̇ce Şenli̇kci̇, Asi̇ye İzem Sandal, Ramazan Arici, Özen Banu Özdaş

Turkish Journal of Veterinary & Animal Sciences

The sensitivity of ram semen to cryobiological procedures has motivated many researchers to investigate this issue. In clinical practice, one of the main objectives is to reduce the damage caused by freezing cells through the addition of preservatives to semen diluents. In our study, fetal calf serum (15% FCS) and 3–6 mM cysteamine were added to ram semen diluents, and their effects on semen after freeze-thawing were investigated. Semen was collected from five Kıvırcık rams using an electroejaculator and combined in equal volumes (pooling). After macroscopic and microscopic examination, the samples were divided into six equal volumes. Six study groups …

Olaparib And Radiotherapy Induce Type I Interferon- And Cd8+ T Cell-Dependent Sensitization To Immunotherapy In Pancreatic Cancer, Victoria M Valvo, Qiang Zhang, Long Jiang, Erin A Holcomb, Ashley N Pearson, Anna G Edmunds, Hailey G Faulkner, Jadyn G James, Akshay Tate, Amanda K Huber, Zhuwen Wang, Yupei Guo, David Karnak, Leslie A Parsels, Joshua D Parsels, Yu L Lei, Alnawaz Rehemtulla, Heng Lin, Eileen S Carpenter, Daniel R Wahl, Vaibhav Sahai, Theodore S Lawrence, Michael D Green, Meredith A Morgan

Faculty, Staff and Student Publications

PARP inhibitors sensitize pancreatic ductal adenocarcinoma (PDAC) to radiation by inducing DNA damage and replication stress. These mechanisms also have the potential to enhance radiation-induced type I interferon (T1IFN) mediated anti-tumoral immune responses. We hypothesized that the PARP inhibitor olaparib would also potentiate radiation-induced T1IFN to promote anti-tumor immune responses and sensitization of otherwise resistant PDAC to immunotherapy. To test this hypothesis, we assessed the effects of olaparib and radiation on T1IFN production and sensitivity to αPD-L1 immunotherapy, as well as on the tumor microenvironment by single-cell RNA sequencing (scRNA-seq). We found that olaparib enhanced T1IFN production following radiation and …

Polygenic Scores For Obstructive Sleep Apnoea Reveal Pathways Contributing To Cardiovascular Disease, Nuzulul Kurniansyah, Satu J Strausz, Geetha Chittoor, Shreyash Gupta, Anne E Justice, Yana Hrytsenko, Brendan T Keenan, Brian E Cade, Brian W Spitzer, Heming Wang, Jennifer Huffman, Matthew R Moll, Bernhard Haring, Su Yon Jung, Laura M Raffield, Robert Kaplan, Jerome I Rotter, Stephen S Rich, Sina A Gharib, Traci M Bartz, Peter Y Liu, Han Chen, Myriam Fornage, Lifang Hou, Daniel Levy, Alanna C Morrison, Heather M Ochs-Balcom, Bruce M Psaty, Peter W F Wilson, Kelly Cho, Allan I Pack, Hanna M Ollila, Susan Redline, Daniel J Gottlieb, Tamar Sofer

Faculty, Staff and Student Publications

Background: Obstructive sleep apnoea (OSA) is a common chronic condition, with obesity its strongest risk factor. Polygenic scores (PGSs) summarise the genetic liability to phenotype and can provide insights into relationships between phenotypes. Recently, large datasets that include genetic data and OSA status became available, providing an opportunity to utilise PGS approaches to study the genetic relationship between OSA and other phenotypes, while differentiating OSA-specific from obesity-specific genetic factors.

Methods: Using race/ethnic diverse samples from over 1.2 million individuals from the Million Veteran Program, FinnGen, TOPMed, All of Us (AoU), Geisinger's MyCode, MGB Biobank, and the Human Phenotype Project, we …

Lmp7-Specific Inhibitor M3258 Modulates The Tumor Microenvironment Of Triple-Negative Breast Cancer And Inflammatory Breast Cancer, Xuemei Xie, Jangsoon Lee, Ganiraju C Manyam, Troy Pearson, Gina Walter-Bausch, Manja Friese-Hamim, Sheng Zhao, Julia Jabs, Angela A Manginelli, Nadine Piske, Thomas Mrowiec, Corinna M Wolf, Bharat S Kuntal, Debu Tripathy, Jing Wang, Michael P Sanderson, Naoto T Ueno

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive molecular subtypes of breast cancer. Poor clinical outcomes highlight the pressing need to discover novel targets for the effective treatment of these diseases. LMP7 (β5i/PSMB8), a proteolytic subunit of the immunoproteasome, is implicated in the pathogenesis of multiple myeloma, autoimmune and inflammatory diseases, and inflammation-related cancers. However, the role of LMP7 in TNBC and IBC remains poorly characterized. Here, we evaluated the function of LMP7 in TNBC and IBC using the selective LMP7 inhibitor M3258. In human TNBC patient samples, LMP7 expression correlated strongly with CD8+ T …

Eph Receptors Activate Myeloid Checkpoint Receptor Lilrb5 To Support Tumor Development, Yubo He, Chengcheng Zhang, Lingxiao Tan, Mi Deng, Xiaoye Liu, Ryan Huang, Xing Yang, Jingjing Xie, Qi Lou, Meng Fang, Caroline Smith, Samuel John, Wei Xiong, Xin Li, Cheryl Lewis, Jade Homsi, Ankit Gupta, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

Faculty, Staff and Student Publications

Immunosuppressive myeloid cells are critical obstacles to T cell-centered immune checkpoint blockade therapies, which have been successful in treating a fraction of patients with cancer. How tumor cells interact with myeloid cells to regulate immune responses and tumor development is unclear. In this study, we report that certain membrane tyrosine kinase Eph receptors, including EphA7 and EphB1, specifically bind the immune inhibitory receptors leukocyte Ig-like receptor family B 5 (LILRB5) and LILRB2. These Eph receptors induce LILRB5-mediated signaling activation, and LILRB5 also activates Eph receptor signaling. Activation of LILRB5 promoted immunosuppressive marker expression and inhibited activating marker expression on myeloid …

Deep Learning Based Rapid X-Ray Fluorescence Signal Extraction And Image Reconstruction For Preclinical Benchtop X-Ray Fluorescence Computed Tomography Applications, Amrit Kaphle, Sandun Jayarathna, Sang Hyun Cho

Faculty, Staff and Student Publications

Recent research advances have resulted in an experimental benchtop X-ray fluorescence computed tomography (XFCT) system that likely meets the imaging dose/scan time constraints for benchtop XFCT imaging of live mice injected with gold nanoparticles (GNPs). For routine in vivo benchtop XFCT imaging, however, additional challenges, most notably the need for rapid/near-real-time handling of X-ray fluorescence (XRF) signal extraction and XFCT image reconstruction, must be successfully addressed. Here we propose a novel end-to-end deep learning (DL) framework that integrates a one-dimensional convolutional neural network (1D CNN) for rapid XRF signal extraction with a U-Net model for XFCT image reconstruction. We trained …

Sunrise At The Salton Sea: Environmental Justice, Land Use Change, And Hydrosocial Dynamics Of Solar Energy Transitions In The Imperial Valley, California, Dustin Mulvaney, James J.A. Blair, Alida Cantor

Faculty Research, Scholarly, and Creative Activity

California's Imperial Valley, with lithium-rich geothermal brines, extensive flat agricultural fields with abundant desert sunshine, and access to transmission lines, is a leading case to explore interconnected themes around just energy transitions. Despite being the poorest county in California and one of the smallest, Imperial already provides 15% of the state’s solar electricity, and the region as a whole represents on the order of 25% of the state’s electric power capacity. This paper brings to light frictions over solar energy development that have emerged over the history of solar power development in the southern Salton Sea region. It describes the …

Mesenchymal Stem Cells And Fibroblasts Contribute To Microvascular Proliferation In Glioblastoma And Are Correlated With Immunosuppression And Poor Outcome, Candice C Poon, Shelley M Herbrich, Yulong Chen, Anwar Hossain, Gregory N Fuller, Sonali Jindal, Sreyashi Basu, Daniel Ledbetter, Marc Macaluso, Lynnette M Phillips, Joy Gumin, Zhong He, Brittany C Parker Kerrigan, Sanjay K Singh, Pratishtha Singh, Mohammed Fayyad Zaman, Derek Ng Tang, Sangeeta Goswami, Frederick F Lang, Padmanee Sharma

Faculty, Staff and Student Publications

Microvascular proliferation (MVP) is a disease-defining hallmark of glioblastoma and other World Health Organization grade 4 gliomas. MVP also serves as a poor prognostic marker in various solid tumors. Despite its clinical significance, the mechanisms and biological consequences of MVP are controversial and remain unclear. In this study, we performed single-cell RNA sequencing on paired CD45-CD105+ vascular/perivascular stromal cells (PVSC) and CD45+CD105± immune cells from 16 primary glioma patient samples, both with and without MVP. This analysis revealed the presence of developmentally related mesenchymal stem cells alongside cancer-associated fibroblasts, pericytes, fibromyocytes, and smooth muscle cells within the CD45-CD105+ compartment. RNA …

Intersectionality And Experiences With Mental Health Care: Transgender And Gender Diverse Autistic Adults, Megan Callahan

LSU Doctoral Dissertations

Current prevalence rates of autism spectrum disorder (ASD) in transgender and gender diverse (TGD) populations range between 4 and 13% (Thrower et al., 2020). Studies into autistic TGD individuals’ experiences with healthcare have primarily collected qualitative data, identifying themes including barriers to healthcare, invalidation of both autistic and TGD identities, difficulty finding competent providers, limited support and resources, and refusal of care (Cooper et al., 2022; Maroney & Horne, 2022; Hall et al., 2020). N = 3094 self-identified TGD adults completed the 2017 TransLifeline Mental Health Survey, a collaborative effort between the National LGBTQ Task Force and the TransLifeline, which …

Importance Of Outbreak Response Research In Bridging Knowledge Gaps On Emerging Infectious Diseases, Robert F Breiman, David Wang, Michael Diamond, Adrianus C M Boon, Et Al.

2020-Current year OA Pubs

An important outcome of the devastating 2014 West African Ebola virus disease outbreak and the 2020 COVID-19 pandemic has been the growing promotion of conducting research during outbreaks of emerging infectious diseases (EIDs) as a valuable and acceptable process of acquiring knowledge to enhance our ability to better prevent and control these diseases in the future. Recognising the unique opportunity during outbreaks to leverage increases in cases over a short time interval and in a circumscribed area, we articulate a systematic process of conducting EID outbreak response research, highlighting knowledge gaps that should be prioritised, and measures that can be …

Effect Of Application Of Epiphytic Yeast Meyerozyma Guilliermondii Squcc-33y And Tamarindus Indica Leaf Extract On Alternaria Alternata-Induced Post-Harvest Black Mold Rot Of Tomato Fruits, Samiya Saleh Al-Maawali, Abdullah Mohammed Al-Sadi, Zahra Al-Kharousi, Rahil Said Al-Badi, Issa Hashil Al-Mahmooli, Rethinasamy Velazhahan

Journal of Agricultural and Marine Sciences

Black mold rot of tomato (Solanum lycopersicum Mill) fruits, incited by Alternaria alternata, is a major constraint in tomato production worldwide. The fungus invades unripe fruits in the field, remains dormant and then cause symptoms as the fruits begin to ripe. In this study, the effectiveness of the antagonistic yeast Meyerozyma guilliermondii SQUCC-33Y and Tamarindus indica leaf extract was assessed for controlling post-harvest black mold fruit rot of tomato. Greenhouse and field tests revealed that pre-harvest application of M. guilliermondii at weekly intervals starting from fruit set to harvest stage significantly reduced the development of post-harvest fruit rot when challenge-inoculated …

Christ-Centered Reasoning: A Platform And Framework For Integrating Christian Faith Into Higher Education., Jf Jf

International Christian Community of Teacher Educators Journal

The integration of Christian faith in higher education can be challenging, as the parameters and scope of integration are not always clear. Notably, the term ‘integration’ has been overused and/or thrown around without distinction within the Christian Liberal Arts halls of learning. Generally, no principles are provided for integration in terms of curriculum, pedagogy, or learning; hence, a clear articulation is required regarding what integration entails with respect to curricula, learning, and pedagogy. There is also an urgent need to theorize integration practically and pragmatically within higher education, particularly in relation to inquiry methodologies and discipline-specific specializations. One way to …

“Any Black Man Will Do”: A Transparency Framework For Eyewitness Identification In The Facial Recognition Technology Era, Ariam O. Kiflemariam

Washington Journal of Social & Environmental Justice

No abstract provided.

Unravelling Host Defense And Pathogen Virulence In Fusarium Proliferatum-Induced Sudden Decline Syndrome Of Date Palm In The Uae, Gouthaman Puthan Purayil

Thesis/ Dissertation Defenses

Sudden decline syndrome (SDS) poses a significant threat to the date palm (Phoenix dactylifera), a crop of critical agricultural and cultural importance in arid regions. Despite its growing impact, the molecular basis of the host-pathogen interactions driving this disease remains poorly understood. This dissertation investigates the disease dynamics of SDS, a severe affliction of date palm caused by the fungal pathogen Fusarium proliferatum DSM 106835 (Fp). The objective of this study is to elucidate the molecular mechanisms underlying Fp infection in date palm and characterize the plant defense responses. To achieve this, whole-genome sequencing (WGS) of the novel Fp strain …

Proceedings From The Sixth Annual Society For Sports Neuroscience Conference, Neurosports Editorial Staff

Journal for Sports Neuroscience

Proceedings from the Sixth Annual Society for Sports Neuroscience Conference

Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney

Watershed Sciences Faculty Publications

Microplastics are found in Earth's atmosphere, lithosphere, hydrosphere, pedosphere, and ecosphere. While there is a growing interest and need to solve this grand challenge in both the academic and policy realms, few have engaged with academics, policymakers, and community partners to co-identify the problem, co-design research, and co-produce knowledge in tackling this issue. Using a convergence research framework, we investigated the perception of microplastic pollution among different end users, delivered educational materials to K-12 teachers and practitioners, and identified key sampling points for assessing environmental microplastic concentrations in the Columbia River Basin, United States. Three community partner workshops identified regional …

Academic Senate - Agenda, 6/3/2025, Academic Senate

Academic Senate Agendas

No abstract provided.

Maternal Loss Of Mouse Nlrp2 Alters The Transcriptome And Dna Methylome In Gv Oocytes And Impairs Zygotic Genome Activation In Embryos, Zahra Anvar, Michael D Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K To, Daniel C Kraushaar, Ying-Wooi Wan, Michael C Mari, Simon Andrews, Gavin Kelsey, Ignatia B Van Den Veyver

Center for Medical Ethics and Health Policy Staff Publications

Background: NLRP2 is a subcortical maternal complex (SCMC) protein of mammalian oocytes and preimplantation embryos. SCMC proteins are encoded by maternal effect genes and play a pivotal role in the maternal-to-zygotic transition (MZT), early embryogenesis, and epigenetic (re)programming. Maternal inactivation of genes encoding SCMC proteins has been linked to infertility and subfertility in mice and humans, but the underlying molecular mechanisms for the diverse functions of SCMC proteins, and specifically the role of NLRP2, are incompletely understood.

Results: We profiled the DNA methylome of pre-ovulatory germinal-vesicle (GV) oocytes from Nlrp2-null, heterozygous (Het), and wild-type (WT) female mice and assessed the …

Unseen Burdens: Exploring Gender Disparities In Infertility Experience And Depressive Symptoms, Khiara Cardoza Brown

Theses and Dissertations

This study examines how experiences with infertility relate to mental health outcomes among newly married U.S. couples, emphasizing gender differences and the potential moderating role of gender attitudes. Using data from 3,137 individuals in a nationally representative sample, three Actor-Partner Interdependence Models were estimated: first assessing actor and partner effects of infertility on depressive symptoms and subsequently incorporating gender attitudes as moderators. Results indicated a significant actor effect for wives, where infertility was associated with higher levels of depressive symptoms, and this association was significantly stronger for wives than for husbands. No significant effects were found for husbands' infertility and …

Investigating The Consequences Of Conjugated And Secreted Isg15 On Coronavirus Pathogenesis, Mudassir Syed Ali

Dissertations

Coronaviruses have evolved a breadth of mechanisms to antagonize host innate immune responses. One widely studied mechanism is the ability to deconjugate ISG15 from target proteins in a process called deISGylation, which is catalyzed by the papain-like protease (PLP) domain of viral non-structural protein (nsp) 3. Since PLP activity is required for viral replication, it has been challenging to generate an infectious virus with a PLP that maintains protease activity but has lost deISGylase activity. In this study, we generated a chimeric MHV-A59 with its PLP2 domain replaced with that of the human coronavirus HKU1, which has been documented to …

Emerging Therapeutic Potential Of Fisetin For Nephrotoxicity, Kidney Injury, And Nephropathy: A Systematic Review, Saeed Mohajeri, Alizamen Salehifard Jouneghani, Saeid Heidari-Soureshjani, Catherine M.T. Sherwin, Faramarz Beigi

Pediatrics Faculty Publications

INTRODUCTION/OBJECTIVE: Kidney diseases cause high morbidity and mortality worldwide. This study investigated the mechanistic effects of Fisetin (FIS) on nephrotoxicity, kidney injury, and nephropathy induced by drugs, toxic chemicals, diabetes, lupus, diet, ureteral obstruction, and ischemic situations.

METHODS: To identify pertinent articles published before Oct 1, 2024, a comprehensive electronic search was performed across several databases, including MEDLINE/PubMed, Embase, Cochrane Library, Web of Science, and Scopus. After establishing clear inclusion and exclusion criteria, studies that met the research objectives were selected. Data were extracted and analyzed, documenting study characteristics, methodologies, and biological mechanisms.

RESULTS: Antioxidant benefits were evident with increased …

Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise F. Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney

Geography Faculty Publications and Presentations

Microplastics are found in Earth’s atmosphere, lithosphere, hydrosphere, pedosphere, and ecosphere. While there is a growing interest and need to solve this grand challenge in both the academic and policy realms, few have engaged with academics, policymakers, and community partners to co-identify the problem, co-design research, and co-produce knowledge in tackling this issue. Using a convergence research framework, we investigated the perception of microplastic pollution among different end users, delivered educational materials to K-12 teachers and practitioners, and identified key sampling points for assessing environmental microplastic concentrations in the Columbia River Basin, United States. Three community partner workshops identified regional …

The (Dis)Continuity Of Meaning In John Dewey’S Experience And Nature, Harrison S. Jackson

Center for Dewey Studies Essay Award

Experience and Nature proposes a naturalistic empiricism emphasizing continuity. This paper will argue that this continuity is threatened by Dewey’s anthropocentric in its account of meaning, which is only found in humans but is necessary for the perception of objects, communication, and social existence. Given contemporary research in ethology, Dewey’s denotative method requires a modification of this account. I will propose Merleau-Ponty’s notion of sense or the neuroscientific theory of enactivism as supplements preserving embodiment and social communication while being more continuous. Finally, I examine some recent applications of Dewey’s naturalism and show how they modify this account of meaning.

Atp8b1 Regulates Pip2 Localization And Cleavage Of Pyroptotic Executioner Gasdermin D, Nilam Bhandari, Ashutosh Prince, Mariam R. Khan, Alicia Traughbera, Kalash Neupane, Shuhui W. Lorkowski, Gregory Brubaker, Elif G. Ertugral, Chandrasekhar R. Kothapalli

Chemical & Biomedical Engineering Faculty Publications

Mutations in ATP8B1 cause progressive familial intrahepatic cholestasis, with symptoms including pruritus, pancreatitis, fat malabsorption, intestinal inflammation, and failure to thrive. High-throughput studies showed interconnection between ATP8B1 and phosphoinositide (PIPs), but the mechanism linking ATP8B1, lipid metabolism, and inflammation remains unclear. Atp8b1G308V/G308V mouse model, unbiased RNAseq, high-resolution-stimulation emission depltion (STED)-microscopy, and Crispr-Cas9 generated ATP8B1-/- knockouts in hepatocytes/monocytes/macrophages were used to determine role of ATP8B1 in phosphatidylinositol,4-5-bisphosphate (PIP2) trafficking and inflammation. Human ATP8B1, purified from Sf9 insect cells and reconstituted in proteoliposomes, was used to test cell-free PIP2 flip. Various in-vitro techniques were used for testing direct interaction between PIP2 and …

Biomarker-Guided Imaging And Ai-Augmented Diagnosis Of Degenerative Joint Disease, Rahul Kumar, Kyle Sporn, Aryan Borole, Akshay Khanna, Chirag Gowda, Phani Paladugu, Alex Ngo, Ram Jagadeesan, Nasif Zaman, Alireza Tavakkoli

Department of Medicine Faculty Papers

Degenerative joint disease remains a leading cause of global disability, with early diagnosis posing a significant clinical challenge due to its gradual onset and symptom overlap with other musculoskeletal disorders. This review focuses on emerging diagnostic strategies by synthesizing evidence specifically from studies that integrate biochemical biomarkers, advanced imaging techniques, and machine learning models relevant to osteoarthritis. We evaluate the diagnostic utility of cartilage degradation markers (e.g., CTX-II, COMP), inflammatory cytokines (e.g., IL-1β, TNF-α), and synovial fluid microRNA profiles, and how they correlate with quantitative imaging readouts from T2-mapping MRI, ultrasound elastography, and dual-energy CT. Furthermore, we highlight recent developments …

Electrochemical Three-Dimensional Printing And Soldering, Arash Takshi, Sabrina Marie Rosa-Ortiz

USF Patents

A hydrogen evolution assisted electroplating nozzle includes a nozzle tip configured to interface with a portion of a substructure. The nozzle also includes an inner coaxial tube connected to a reservoir containing an electrolyte and an anode, the inner coaxial tube configured to dispense the electrolyte through the nozzle tip onto the portion of the substructure. The nozzle also includes an outer coaxial tube encompassing the inner coaxial tube, the outer coaxial tube configured to extract the electrolyte from the portion of the substructure. The nozzle also includes at least one contact pin configured to make electrical contact with a …