Digital Commons Network^™

Topological Indices For The Resize Graph Of (G2(3)), Manar Musab Ftekhan, Ali Abd Aubad

Iraqi Journal for Computer Science and Mathematics

Indexes of topological play a crucial role in mathematical chemistry and network theory, providing valuable insights into the structural properties of graphs. In this study, we investigate the Resize graph of G₂(3), a significant algebraic structure arising from the exceptional Lie group (G₂) over the finite field F₃. We compute several well-known topological indices, including the Zagreb indices, Wiener index, and Randić index, to analyze the graph's connectivity and complexity. Our results reveal intricate relationships between the algebraic structure of G₂(3) and its graphical properties, offering a deeper understanding of its combinatorial …

The Minutes Of The Marshall University Board Of Governors Meeting, June 11, 2025, Marshall University Board Of Governors

Board of Governors Minutes

No abstract provided.

Virtual Assistant For Pest Management, Viswanada Chakravarthy Karri

Master’s Dissertations

Effective pest identification and management are essential for ensuring agricultural productivity, especially in regions with limited expert access. This work proposes a virtual assistant based on a Retrieval-Augmented Generation (RAG) [1] framework to support pest management tasks. The system utilizes a multimodal dataset consisting of pest images and annotated textual interactions, adapted from the AgriLLaVA corpus [2]. The assistant combines retrieval mechanisms with generative language models to generate contextually grounded responses. It is designed for deployment on local hardware with limited computational resources, integrating open-source models for both retrieval and generation. Preliminary results suggest that this approach can provide accurate, …

Panel 1: Environmental Enforcement Under New Administrative Law Principles, Sommer H. Engels, Jeffrey W. Mccoy, Melissa A. Scacchitti, David M. Uhlmann

Villanova Environmental Law Journal (1991 - )

No abstract provided.

A Modern Moby-Dick: The First Circuit Reveals How Man's Unchecked Fixations Still Impact Nantucket's North Atlantic Right Whale In Nantucket Residents Against Turbines V. U.S. Bureau Of Ocean Energy Management, Julia A. Snyder

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Highly Adaptable Dendrimer Gel Nanoparticles With Dual Targeting Of Upar And Ribonucleotide Reductase R2 For Better Retention And Improved Therapeutic Outcomes In Triple-Negative Breast Cancer, Hsin Yin Chuang, Da Huang, Lin Qi, Vidit Singh, Anna Chernatynskaya, Yue-Wern Huang, Hu Yang

Biological Sciences Faculty Research & Creative Works

Triple-negative breast cancer (TNBC) accounts for approximately 15% of breast cancers and lacks estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), rendering it unresponsive to hormonal or anti-HER2 therapies. Due to its poor prognosis and limited treatment options, there is an urgent need for targeted therapies. In this study, we developed highly adaptable polyamidoamine (PAMAM) dendrimer-based gel nanoparticles with dual-targeting capabilities against urokinase-type plasminogen activator receptor (uPAR) and ribonucleotide reductase R2 (R2). These nanoparticles were designed to target both TNBC cells and cancer-associated stromal cells by leveraging uPA-uPAR interactions and delivering the antisense oligonucleotide …

An Examination Of How Technological Universities Develop Cultural Capital Through Active Learning, Emma Carroll Dr, Orla Watson, Aisling M. Burke

Irish Journal of Academic Practice

Drawing on Bourdieu’s (1986) framework of embodied, objectified and institutionalised capital, this paper explores how technological universities (TUs) support the development of students’ cultural capital through active learning approaches. The formation of technological universities in Ireland marked a notable shift in the higher education landscape, with an emphasis on these institutions meeting the regional and economic needs of the location in which they operate. Currently, there is a dearth of studies pertaining to cultural capital and TUs. Consequently, there is an impetus for a conceptual study to help guide researchers towards understanding how active learning practices within Ireland’s TUs can …

Surface-Bound Fxiii Enhances Deposition And Straightness Of Fibrin Fibers, Myra Awan, Maya Papez, Ankita P. Walvekar, Sang Joon J. Lee, Kinjal Dasbiswas, Anand K. Ramasubramanian

Faculty Research, Scholarly, and Creative Activity

Cross-linked fibrous networks are central to maintaining the structural integrity and functional relevance of many biological and engineered materials. Fibrin networks are the building blocks of blood clots, mediators of tissue injury and repair, and synthetic wound sealants. Cross-linking of fibrin fibers is catalyzed by the activated form of transglutaminase enzyme FXIIIa, which becomes available in plasma but is also readily presented on the surface of activated platelets and macrophages. The contribution of surface-bound FXIIIa to fibrin structure has not been well understood. In this work, we investigated the role of surface-bound FXIIIa on the formation and structure of fibrin …

Working Mothers And Children’S Social-Emotional Development: Struggling With Family And Job Roles In Dar Es Salaam, Tanzania, Ignasia Paskal Mbatta

Journal of Humanities and Social Sciences

This study aimed at examining the socio-emotional development of employed mothers’ children in the metropolis of Dar es Salaam. Early childhood socio-emotional development is crucial for shaping a child’s short- and long-term well-being, relationships, and overall mental health. An exploratory qualitative approach employing a phenomenological design, guided this study. In-depth interviews, documentary reviews, and active participant observation were used to collect data. The study sample comprised of 42 working mothers, 9 domestic workers, and 90 children under five years of age of the same mothers. Purposive sampling was used to select working mothers, while domestic workers were selected incidentally. The …

Captured And Enhanced Potentials Of Wild Edible Fruits In Tabora Rural, Uyui And Sikonge Districts, Tabora In Tanzania, Mirau N. Mbise

Journal of Humanities and Social Sciences

Rural communities worldwide supplement food and income through wild edible fruits. However, the paucity of scientific inquiry on the perceptions and uses of wild edible fruits, value-addition, and marketing prompted this study. It interviewed respondents from 274 households in Tabora rural, Sikonge, and Uyui districts in the Tabora region of Tanzania. Descriptive and quantitative analyses were undertaken, and results showed that wild edible fruit activities are perceived to be for women, children, and less-educated people. Furthermore, the findings indicated that 100% (n = 274) of the respondents use wild edible fruits as food, and 48.6% (n = 133) use them …

Rethinking Large-Scale Phylogenomics With Eukphylo V.1.0, A Flexible Toolkit To Enable Phylogeny-Informed Data Curation And Analyses Of Diverse Eukaryotic Lineages, Laura A. Katz, Marie Leleu, Godwin Ani, Rebecca Gawron, Auden Cote-L'Heureux

Biological Sciences: Faculty Publications

Eukaryotic diversity is largely microbial, with macroscopic lineages (plants, animals, and fungi) nesting among a plethora of diverse protists. Our understanding of the evolutionary relationships among eukaryotes is rapidly advancing through ’omics analyses, but phylogenomic analyses are challenging for microeukaryotes, particularly uncultivable lineages, as single-cell sequencing approaches generate a mixture of sequences from hosts, associated microbiomes, and contaminants. Moreover, many analyses of eukaryotic gene families and phylogenies rely on boutique data sets and methods that are challenging for other research groups to replicate. To address these challenges, we present EukPhylo v.1.0, a modular, user-friendly pipeline that enables effective data curation …

A Monumental Tug Of War: The Clash Over Presidential Authority And National Monuments In Murphy Co. V. Biden, Benjamin S. Levy

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Pressure In The Pipeline? Hidden Tensions Beneath The Surface In The D.C. Circuit's Analysis Of Alabama Municipal Distributors Group V. Federal Energy Regulatory Commission, Marina Campo

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Electric Weed Control—How Does It Compare To Conventional Weed Control Methods?, Catherine Borger, Miranda J. Slaven

Journal articles

Weed management practices in agroecosystems mainly rely on herbicide, mowing, or tillage. Electric weed control offers a novel alternative, with a range of commercially available products for weed management in agricultural environments. However, electrical weed control efficacy has not been effectively compared with conventional weed management practices. Further, electrical weed control products may have a fire risk, as highlighted but not assessed in prior studies. The current study evaluated an electric weed control machine (Zasso™ XPower) for weed management in four vineyard sites (in 2022 and 2023) in comparison to mowing and herbicide applications. Weed control tactics were applied in …

Multigenerational Exposure To Glyphosate Has Only Modest Effects On Life-History Traits, Stress Tolerance And Microbiome In A Field Cricket, J. W. Whitlock, P. M. Orwin, Z. R. Stahlschmidt

Pacific Faculty Work

Glyphosate is the most used herbicide worldwide, and it can be toxic to off-target species, such as insects. Although GLY-based herbicides (GBHs) can influence insect microbiomes, little is known about its cascading effects on fitness-related traits, such as life history or stress tolerance, especially in the context of long-term, multigenerational exposure. Thus, we exposed the variable field cricket, Gryllus lineaticeps, to GBH within and across generations to examine the potential role of GBH in developmental plasticity and evolution. Specifically, we measured its effects on life-history traits (e.g. developmental duration, adult body size and mass, and a life-history trade-off between investment …

Exploring The Connection Between Mental Health Stigma, Social-Emotional Risk, And Help-Seeking Behaviors Among High School Students, Dorie Ross

USF Tampa Graduate Theses and Dissertations

Throughout the United States, the rate of adolescents experiencing mental health-related challenges continues to rise, impacting their social-emotional well-being. Despite increasing concerns, the majority of adolescents do not seek treatment for mental health problems. One barrier contributing to a lack of help-seeking behaviors is mental health stigma. Furthermore, for students who have sought help for such concerns, there is a lack of consensus on whom high school students turn to for support when seeking help. The current study utilized quantitative methodology in the form of Structural Equation Modeling to examine the complex relationship between social-emotional risk, perceptions of mental health …

Modernism’S Mythic Mothers: Queering Motherhood Through Classical Matrilineage, Samantha Marie Lepak

Dissertations

I position this dissertation at the intersection of modern/contemporary literature, queer/feminist theory, and ancient Greek classics in the hopes of better understanding the spaces in which they meet, engaging with writers from the late modernist era to the present in order to highlight the connections between theories, themes, and practices of queerness from the modernists forward. Using the work of H.D. and writers following in her footsteps, I argue that exploring adaptations of Greek classics written primarily by female and gender-variant authors from the modernist era forward illuminates the extent to which the classics enables writers to “think queerly,” considering …

Maternal Access For Depression In Rural Environments, Simone Parlier

Dissertations

Significance –As many as 25% of birthing persons experience postpartum depression (PPD) within the first year after childbirth making this one of the most common postpartum disorders. PPD is prevalent, incapacitating, and treatable. The first step is identifying those at risk. Rural birthing persons are understudied, and may have unique predisposing characteristics as well as geographic challenges for optimal detection and treatment of PPD. Purpose -The long-term goal is to improve the health of rural families. Using The Theory of Unpleasant Symptoms, the purpose of this descriptive, cross-sectional research was to describe the prevalence of PPD in rural birthing persons …

Anthropogenic Litter In Freshwater Ecosystems: Effect On Ecosystem Processes And Spatial Distribution, Emily Johnson

Master's Theses

The rapid increase of plastic production and disposal into the environment has resulted in anthropogenic litter (i.e., trash; AL) becoming a global problem. In aquatic ecosystems, macro- and microplastics are long-lived, mobile, and interact with the physical and chemical components of aquatic ecosystems. Our objectives were to: (1) assess the impact of microplastic pollution on the ecosystem processes of ecosystem metabolism and N2 flux in an oligotrophic lake and (2) to assess the abundance and assemblage of anthropogenic litter in a large urban river. For objective (1), we added microplastics at a range of concentrations to littoral mesocosms. Ecosystem metabolism …

Citrullinated Eno1 Vaccine Enhances Pd-1 Blockade In Mice Implanted With Murine Triple-Negative Breast Cancer Cells, Ricardo A León-Letelier, Alejandro M Sevillano-Mantas, Yihui Chen, Soyoung Park, Jody Vykoukal, Johannes F Fahrmann, Edwin J Ostrin, Candace Garrett, Rongzhang Dou, Yining Cai, Fu-Chung Hsiao, Jennifer B Dennison, Eduardo Vilar, Banu K Arun, Samir Hanash, Hiroyuki Katayama

Faculty, Staff and Student Publications

Background/Objectives:Cancer vaccine targets mostly include mutations and overexpressed proteins. However, cancer-associated post-translational modifications (PTMs) may also induce immune responses. Previously, our group established the enzyme protein arginine deiminase type-2 (PADI2), which catalyzes citrullination modification, is highly expressed in triple-negative breast cancer (TNBC), promoting antigenicity.

Methods: Here, we show the workflow of designing citrullinated enolase 1 (citENO1) vaccine peptides identified from breast cancer cells by mass spectrometry and demonstrate TNBC vaccine efficacy in the mouse model. Immunized mice with citENO1 peptides or the corresponding unmodified peptides, plus Poly I:C as an adjuvant, were orthotopically implanted with a TNBC murine …

Inactivation Of The Fusobacterium Nucleatum Rnf Complex Reduces Fada-Mediated Amyloid Formation And Tumor Development, Timmie A Britton, Ju Huck Lee, Chungyu Chang, Aadil H Bhat, Yi-Wei Chen, Rusul Mohammed Ali, Chenggang Wu, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

The Gram-negative anaerobe Fusobacterium nucleatum is an oral oncobacterium that promotes colorectal cancer (CRC) development with the amyloid-forming cell surface adhesin FadA integral to CRC tumorigenesis. We describe here molecular genetic studies uncovering a novel mode of metabolic regulation of FadA-mediated tumor formation by a highly conserved respiratory enzyme known as the Rnf complex. First, we show that genetic disruption of Rnf, via rnfC deletion, significantly reduces the level of fadA transcript, accompanied by a near-complete abolishment of the precursor form of FadA (pFadA), reduced assembly of FadA at the mature cell pole, and severe defects in the osmotic stress-induced …

Proteomic-Based Stemness Score Measures Oncogenic Dedifferentiation And Enables The Identification Of Druggable Targets, Iga Kołodziejczak-Guglas, Renan L S Simões, Emerson De Souza Santos, Elizabeth G Demicco, Rossana N Lazcano Segura, Weiping Ma, Pei Wang, Yifat Geffen, Erik Storrs, Francesca Petralia, Antonio Colaprico, Felipe Da Veiga Leprevost, Pietro Pugliese, Michele Ceccarelli, Houtan Noushmehr, Alexey I Nesvizhskii, Bożena Kamińska, Waldemar Priebe, Jan Lubiński, Bing Zhang, Alexander J Lazar, Paweł Kurzawa, Mehdi Mesri, Ana I Robles, Clinical Proteomic Tumor Analysis Consortium, Li Ding, Tathiane M Malta, Maciej Wiznerowicz

Faculty, Staff and Student Publications

Cancer progression and therapeutic resistance are closely linked to a stemness phenotype. Here, we introduce a protein-expression-based stemness index (PROTsi) to evaluate oncogenic dedifferentiation in relation to histopathology, molecular features, and clinical outcomes. Utilizing datasets from the Clinical Proteomic Tumor Analysis Consortium across 11 tumor types, we validate PROTsi's effectiveness in accurately quantifying stem-like features. Through integration of PROTsi with multi-omics, including protein post-translational modifications, we identify molecular features associated with stemness and proteins that act as active nodes within transcriptional networks, driving tumor aggressiveness. Proteins highly correlated with stemness were identified as potential drug targets, both shared and tumor …

Green Technologies For Isolating Bioactives From Plant-Based Food And Their Applications In Human Health And Longevity, Vibha Gajbe, Azza S. Naik, Roji Waghmare, Shuchi Midha

Research Outputs: 2025-Present

No abstract provided.

Evaluating The Use Of Repetitive Transcranial Magnetic Stimulation In A Patient With Treatment Resistant Depression, Autism Spectrum Disorder, And Post-Traumatic Stress Disorder: A Case Report, Luke Fritsch Ba, Mba, Msiv, Oluwafunke O. Ogunremi Bs, Msiv, Alexandra R. Job Bs, Msiv, James Hellekson Md

Aesculapius Journal (Health Sciences & Medicine)

Despite a wide array of therapeutic modalities, many patients with Major Depressive Disorder (MDD) experience no significant improvement in symptoms with traditional treatment. Given the prevalence of Treatment Resistant Depression (TRD), other alternative therapeutic modalities for MDD are being researched. Repetitive Transcranial Magnetic Stimulation (rTMS) is one modality that continues to show successful therapeutic outcomes for those with TRD. The aim of this study is to highlight a case of rTMS being used on a patient with TRD, autism spectrum disorder (ASD), post-traumatic stress disorder (PTSD), and substance use.

Methods:

Our patient is a 53-year-old female who first presented to …

Orca Annual Report 2024-25, Msu Orca

Steeplechase: An ORCA Student Journal

Quick Facts about ORCA in Academic Year 2024-25

• 12 slots filled for Posters-at-the-Capitol
• 346+ students presented at Scholars Weeks with support from 110+ faculty members
• 28 grants awarded totalling over $23,000
• Dr. Kelly Taylor named University Distinguished Mentor 2025

Why Acromegaly Dies: A Systematic Review, Isam Noori Salman, Safaa Ehssan Atta, Baydaa Ahmed Abed, Noor Ulhuda G. Mohammed

Maaen Journal for Medical Sciences

Acromegaly is a rare endocrine clinical syndrome characterized by long-term elevated production of growth hormone (GH) due to a pituitary adenoma tumor. The main problem of acromegaly patients (AC-PTs) is prolonged elevated GH concentration, which leads to increased insulin-like growth factor 1 (IGF-1) production, causing the characteristic tissue and bone overgrowth. The appearance of diabetes in AC-PTs was linked with the high risks of cardiovascular morbidity, indicating that individuals with both conditions face heightened health challenges. Acromegaly typically has a higher cancer incidence rather than the general population. Without early diagnosis and effective treatment, excess GH can have widespread systemic …

Does The Organization–Employee Relationship Matter? Linking The Organization–Employee Relationship With Employee Well-Being And Performance, Deepti Pathak, Gaurav Joshi

Economic and Business Review

The study examines the relationship between the organization–employee relationship (OER), well-being, and work performance of remote workers who were mandated to work from home because of the uncertainties and health risks brought about by the COVID-19 pandemic. This study focuses on the work performance of the employees contributed through positive psychological well-being and positive OERs. A comprehensive nationwide survey was undertaken, involving a sample size of 1289 full-time IT employees in India, with the objective of determining the impact of well-being on individual work performance. Results from the analyses indicate that though the employees with limited experience of work from …

St. Louis, Missouri’S Gayborhood And Washington, Dc’S Black Lives Matter Plaza: Revealing The Healing Potential Of Resistance Stories That Are Grounded In Place, Ryan R. Lindsay, Lotte I. Lent, Ackesha J. Patrick

Dissertations

Oppressed people resist, even when facing severe consequences for doing so. At the core of systemic oppression—genocide, slavery, racism, and sexism—is a drive to control and dehumanize. Resistance, however, can serve as a powerful act of rehumanization. From enslaved individuals fleeing plantations to LGBTQ+ individuals risking arrest to gather in mid-20th-century bars, resistance reclaims power and autonomy under oppressive regimes. This study applies South Africa’s Truth and Reconciliation Commission (TRC) “four truths” framework—comprising forensic, personal, social, and healing truths—to the interpretation of contested heritage sites. We argue that sites commemorating resistance hold transformative potential for individual and community healing. Using …

Neural Engineering In Action: Exploring Muscle Movement Through Data And Design, Dr. Ashwin Mohan, Dr. Sowmya Anjur, Mrs. Namrata Pandya, Matthew Stroud, Dr. David Bergin Emeritus, Dr. Satish Nair

2025

No abstract provided.

High-Salt Tumor Microenvironment: Not As Bad As It Sounds, Not As Good As It Seems, Umer Ali, Venkataswarup Tiriveedhi

Biology Faculty Research

Recent evidence suggests a high-sodium microenvironment in breast tumors. However, the exact role of this high-sodium microenvironment on tumorigenesis is unknown. Salt (sodium chloride, NaCl) is a well-known inflammatory molecule playing a significant role in various chronic ailments like cardiovascular and autoimmune diseases. Importantly, chronic inflammation is recognized as one of the major hallmarks of carcinogenesis. Breast cancer cell culture-based studies demonstrated that high-salt (HS) treatment (Δ35–50 mM NaCl) induced cancer cell proliferation. However, preclinical murine research showed reduced tumor progression kinetics in mice fed a short-term HS diet (4% NaCl diet, 0–2 weeks prior to the injection of tumor …