Digital Commons Network^™

Acute Effects Of Blood Flow Restriction During Low-Load Exercise And Recovery On Blood Flow And Performance, Shay B. Richards

Theses and Dissertations

Purpose: Use of blood flow restriction (BFR) during strength training with light loads has been used to induce similar muscular benefits as traditional strength training with heavy loads. Safe and effective recommendations for the use of BFR relies on an understanding of how different methods of BFR alter blood flow during rest and exercise. The purpose of this study was to compare blood flow during exercise and recovery between continuous BFR (CONT), intermittent BFR (INT), and no BFR (NBFR) as a control. Methods: 16 participants (8 male, 8 female) participated in this study on three different days, separated by at …

Tunable Methacrylated Decellularized Heart Matrix: A Versatile Scaffold For Cardiac Tissue Engineering, Valinteshley Pierre, Douglas H. Wu, Chao Liu, Elif Ertugral, Chandrasekhar R. Kothapalli, Samuel E. Senyo

Chemical & Biomedical Engineering Faculty Publications

Therapeutic tissue regeneration remains a significant unmet need in heart failure and cardiovascular disease treatment, which are among the leading causes of death globally. Decellularized heart matrix (DHM) offer promising advantages for tissue engineering, including low immunogenicity and seamless integration into biological processes, facilitating biocompatibility. However, DHM is challenged by weak mechanical properties that limit its utility to biomedical applications like tissue engineering. To address this limitation, we functionalized DHM with methacryloyl functional groups (DHMMA) that support UV-induced crosslinking to enhance mechanical properties. By modulating the degree of methacryloyl substitution, a broad range of stiffness was achieved while maintaining cell …

Loss Of Neuropeptide F (Npf) Signaling Reduces The Strength Of Circadian Rest-Activity Rhythms But Not Feeding-Fasting Rhythms, Katelyn Ann Wendt

Master's Theses

The circadian system governs crucial physiological and behavioral processes, dictating activities like movement, hormone release, and sleep patterns over a 24-hour cycle. Disruptions to these rhythms can lead to various health problems, including cardiometabolic dysfunction. Research has demonstrated the presence of circadian rhythms of feeding behavior in diverse organisms, but the specific molecules involved are not yet identified. Neuropeptide Y (NPY) influences metabolic activity in mammals, and its counterpart, NPF, affects locomotor activity and feeding in Drosophila melanogaster. Our study aims to investigate whether NPF, its receptor (NPFR), and NPF-expressing cells play a role in regulating circadian rest-activity and feeding-fasting …

Enzymatic Characterization Of Bacterial Enzymes And Inhibitors As Potential Antibiotics With New Mechanisms Of Action, Emma Helene Kelley

Dissertations

Bacteria have become increasingly resistant to antibiotics, therefore there is an urgent need for new drug classes of antibiotics to help fight antibiotic infections. To this end, our research is focused on inhibitors of dizinc metalloenzymes N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), an enzyme in the lysine biosynthesis pathway, N-acetyl-L-ornithine deacetylase enzyme (ArgE), an enzyme in the arginine biosynthesis pathway, and sodium-dependent NADH: ubiquinone oxidoreductase (Na+-NQR) enzyme, a respiratory complex enzyme as promising drug targets. DapE, ArgE, and Na+-NQR and are only present in bacteria, including ESKAPE pathogens that can cause potentially deadly infections, thus inhibitors of DapE, ArgE, and Na+-NQR offer …

Utilizing Creative Writing Techniques In First-Year Composition, Brett Moss

Student Theses and Dissertations

One common issue found in first-year composition courses is a lack of emphasis on creative style and writing about writing (WAW) concerns. This thesis is concerned primarily with explaining how creative writing skills can benefit students in first-year composition courses, as well as advocating for more WAW ideas. I argue that by allowing students the chance to write with a more creative mindset in an environment which consciously considers writing as a skill, not just in the English department but across disciplines, a greater understanding of the importance of writing can be gained, along with more transfer skills.

Teacher Perspectives On The Impact Of School-Based Mental Health Services On Academic Performance, Attendance, And Behavior, Carol Ingram

Student Theses and Dissertations

This qualitative instrumental case study explores teacher perspectives on the impact of school-based mental health services on student academic performance, attendance, and behavior in a northern Mississippi school district. Understanding their influence on key student outcomes is crucial given the increasing integration of school-based mental health services in educational settings. Framed by the Collaborative for Academic, Social, and Emotional Learning (CASEL) five core competencies, this study examines how school-based mental health services support these competencies through teachers' insights. Data were collected using criterion sampling, focusing on eight high school teachers through focus groups, individual interviews, and a review of the …

Scientific Imperialism: Science, Nature, Race, And The U.S. Conquest Of California, Jared Dewight Allinson

Student Theses and Dissertations

This thesis explores the connections between scientific language, scientific and commercial ventures, and the impact they had on nineteenth century California. Eighteenth century intellectual movements that emerged from the Scientific Revolution, Industrial Revolution, and the Enlightenment, influenced how U.S. intellectuals perceived both nature and other peoples. By the nineteenth century, U.S. politicians began to promote the scientific exploration of the western regions of North America in order to understand how to better utilize and gain power over natural resources and access to commercial markets. Within these scientific expeditions, scientists, military officials, and artists incorporated new verbiage to not only describe …

The Impact Of Supplemental Resources In Title I Schools On Student Achievement In High School Geometry, Jememia Black

Student Theses and Dissertations

Schools receive report card grades to inform the public about how the schools are performing and meeting the demands of their students. State mandated assessments factor into the report card grades for schools. When test scores are low, they negatively impact the report grades for schools. Therefore, there is a need to explore resources that could positively impact students’ test scores. The problem addressed in this study was that over 50% of the geometry students in Title I high schools within the district included in the study were not performing on grade level and demonstrating grade level understanding on state …

Evolutionary Influences On Oceanic Islands Parasites: Phylogeography, Genetic Structure, And The “Island Rule” Of Common Ground Doves (Columbina Passerina) And Their Lice, Paige Jordan Brewer

Student Theses and Dissertations

Organisms on oceanic island archipelagos often exhibit strong genetic signatures and adaptations. Here, we focus on Common Ground Doves (Columbina passerina) and their parasitic lice, Physconelloides body lice and Columbicola wing lice, across the Caribbean islands to examine phylogeography, population genetics, and the “Island rule”. We used genome-wide sequences and found C. passerina doves and their lice exhibited unique dispersal patterns and phylogenetic relationships; however, similar population structure. We also found distinct patterns of genetic diversity between Physconelloides and Columbicola, likely caused by variations in their dispersal abilities. Additionally, we measured C. passerina specimens and their lice to compare island …

Functional Characterization Of Uncharacterized Essential Genes In The Oral Pathogen Streptococcus Mutans, Courtney Dover

Student Theses and Dissertations

Streptococcus mutans is a pathogen associated with the formation of dental caries, and its genome contains many uncharacterized genes, including some which are classified as essential genes. These genes are required for the growth of the organism. Characterizing the function of these genes is important for understanding the organism, as well as identifying potential antimicrobial targets. This project used a CRISPRi (CRISPR interference) system to repress seven experimentally uncharacterized genes within the S. mutans genome and investigated the effects of their repression via RNA-seq transcriptomics, phylogenetic analysis, and TEM. The gene annotated as SMU_393 was then prioritized for further analysis …

Role Of Gut-Liver-Brain Axis In Neuropsychiatric Symptoms Of Parkinson’S Disease, Raveena Dhanani Ratnayake

Student Theses and Dissertations

Neuropsychiatric symptoms (NPS), such as depression, and anxiety, and mild cognitive impairment (MCI), often precede motor symptoms in Parkinson’s disease (PD), highlighting the need for early biomarkers and mechanistic insights. Gut-microbiome-related metabolites, including secondary bile acids, influence lipid homeostasis and mitochondrial function, impacting neuropsychiatric and neurodegenerative disorders. This study examines metabolic alterations in PD, focusing on lipid metabolism, bile acids, acylcarnitine, and amino acids. Our findings showed significant changes in lipid metabolism, transsulfuration pathway, bile acids, acylcarnitine, and amino acids in PD severity and NPS. Specific lipid subclasses were linked to NPS, cognitive impairment, and motor impairment. Given the limited …

Weather Impacts On Specialty Fruit Wholesale Prices, Oladayo Daniel Oluleye

LSU Master's Theses

This article investigates the relationship between temperature and precipitation variability and wholesale specialty fruit prices in the United States. Using fixed-effects panel regression and a comprehensive dataset of monthly price observations across ten major U.S. wholesale markets (Atlanta, Baltimore, Boston, Chicago, Detroit, Los Angeles, Miami, New York, Philadelphia and San Francisco) from 2000 to 2019, we examine how weather fluctuations affect wholesale market prices for five fruits including apples, avocados, grapes, oranges, and strawberries. Our analysis categorizes temperature into discrete bins representing the number of days per month within specific temperature ranges. The results show that extreme temperatures, particularly above …

The War On Tourer: An Analysis In Terrorism’S Effect On Tourism, Jacob M. Strawn

Student Theses and Dissertations

Tourism is the third largest global export, representing seven percent of all global trade(UNWTO 2021). Many developing countries now depend on tourism to achieve sustainableeconomic growth, a core component of the UN’s 2030 Sustainable Development Goals. Priorstudies of this phenomenon focus on isolated case-studies, mostly based on limited data. Inthis thesis I examine how terrorist incidents and fatalities affect international tourist arrivalsin 93 developing countries from 1995 to 2020. Special focus is placed on potential variablesthat may effect some countries more than others like Post-9/11 Anxiety. An increase in terrorattacks is associated with a decrease in tourism. A separate analysis …

Genetic Structuring Of The Ozark Pocket Gopher (Geomys Bursarius Ozarkensis) And Coevolution With Its Geomydoecus Ectoparasites, Monica Raquel Reusche

Student Theses and Dissertations

The Ozark pocket gopher Geomys bursarius ozarkensis is a highly isolated and restricted subspecies of the plains pocket gopher endemic to Izard Co., Arkansas. This isolation may have impacts genetically and may have caused speciation of their chewing louse. First, I updated the distribution and confirmed occupation at 46 previously documented and 91 additional sites, a 34% increase in areal range. Next, I evaluated natal dispersal which was rare (9.1%) and occurred over shorter distances (≤ 63 m) than for other gopher species. Analysis of single nucleotide polymorphisms from contemporary populations and museum specimens indicated a high genetic structure among …

Arkansas High School Teacher Perceptions About Declining Enrollment And Learning Experiences In Advanced Science Courses, Tanya Lynette Ruble

Student Theses and Dissertations

Student enrollment in advanced high school science courses in Arkansas, specifically Chemistry, Physics, AP Biology, AP Chemistry, and AP Physics has declined since 2014. Colleges across the nation recommend that students take Biology, Chemistry, and Physics in high school to prepare for rigorous science majors in college. Decreased enrollment in these subjects can lead to fewer college science majors and impact the preparation of students for careers in STEM fields such as engineering and healthcare. This qualitative phenomenological study utilized three research questions to explore the reasons for the decline in advanced high school science course enrollment in Arkansas. It …

Front Matter, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

Full Issue, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

A New Model For Educational Program Assessments Using Automated Collective Concept Maps, Andrew R. Paullin

Master's Theses (2009 -)

This paper presents: Epistemological principles; the origins and theoretical foundations of concept maps; the current state of related works; the contributions, methods, results, and future road map of this research; and A New Model for Educational Program Assessments. An understanding that knowledge results from an evolution of cognitive structures enables a scientific approach to enhance the efficiency of learning. Building on prior works, this research provides a novel algorithm and tool to automatically create Collective Concept Maps from Individual Concept Maps by utilizing a dictionary, thesaurus, Natural Language Processing, Machine Learning / Artificial Intelligence, and domain expertise. Abstraction Filters enable …

Stepping Into Motherhood: Pregnancy-Induced Changes To Foot Structure And Biomechanics, Lauren R. Williams

Theses and Dissertations

INTRODUCTION: Pregnant women have an elevated risk of developing lower limb musculoskeletal disorders, likely due to the rapid increase in body mass and joint laxity. While a few studies have evaluated changes in static foot posture due to pregnancy, it is unclear if body mass or joint laxity is the primary driver. Additionally, how pregnancy affects the mechanics of the foot during dynamic movements is still not understood. PURPOSE: The purpose of this study is to investigate the foot's response to pregnancy. First, we examined foot tissue characteristics across pregnancy, specifically plantar fascia (PF) stiffness, length, and thickness. Additionally, we …

The Relative Strength Of Help-Seeker Stereotype, Help-Seeking Self-Stigma, And Self-Esteem In Predicting Attitudes Toward Seeking Mental Health Help, Souad Torjani Azim

Walden Dissertations and Doctoral Studies

The increasing prevalence of mental health issues among college students is a critical concern. Disorders such as depression and anxiety are becoming more common, with depression notably a major risk factor for suicide—the second leading cause of death in this age group. Despite this troubling trend, significant barriers to accessing mental health services remain. While research has explored various factors contributing to students’ reluctance, such as stigma, distrust in the mental health system, lack of social support, and mental health literacy, none to date has examined the relative strength of help-seeker stereotype, help-seeking self-stigma, and self-esteem in predicting attitudes toward …

Preoperative Dialysis Dose And Postoperative Outcomes In Patients Receiving Maintenance Hemodialysis, Vikram Fielding-Singh, Matthew W Vanneman, Arden M Morris, Wolfgang C Winkelmayer, Louise Y Sun, Pavel S Roshanov, Maria Montez-Rath, Glenn M Chertow, Eugene Lin

Faculty, Staff and Students Publications

Background: Little is known about preoperative hemodialysis dosing for patients with end-stage kidney disease. We assessed whether changes in preoperative hemodialysis dose (compared to and controlling for baseline dose) are associated with postoperative mortality in patients receiving maintenance hemodialysis.

Methods: We identified fee-for-service Medicare beneficiaries receiving hemodialysis for end-stage kidney disease who underwent surgical procedures between January 1, 2011, and November 30, 2020. Follow-up ended December 31, 2020. The primary exposure was preoperative change in Kt/Vurea, defined as the difference between the Kt/Vurea in the hemodialysis session proximal to the procedure and the mean Kt/Vurea for the preceding 180 days. …

A Family Navigator Improves Post-Discharge Treatment Adherence Among Adolescents With Anorexia Nervosa: A Pilot Study, Elizabeth V Franklin, Margaret Mathias, Duc T Nguyen, Albert C Hergenroeder, Constance M Wiemann

Faculty, Staff and Students Publications

Background: Adolescent patients with Anorexia Nervosa (AN) and Atypical Anorexia Nervosa (AAN) admitted to an inpatient medical unit are at risk of relapse if they do not receive follow up treatment. Yet treatment adherence following discharge remains poor. One possible reason for poor treatment adherence is insufficient support for parents. This pilot study explored the preliminary impact of a novel family navigator (FN) intervention on adolescent patient treatment adherence following inpatient care.

Methods: This was a pilot prospective study with a retrospective control cohort. Twenty-three adolescent patients with AN or AAN discharging from an Adolescent Medicine inpatient medical unit whose …

Let's Talk About Sex, Baby! Gender Roles In Parent-Child Sexual Communication, Alexandra Henrici

Dissertations and Theses

Parent-child sexual communication remains a fruitful avenue to increase safe sex behaviors, which are currently in decline by today's adolescents. Historically, mothers have reported engaging in parent-child sexual communication more than fathers do. Previous scholarship suggests this difference could be due to traditional gender role beliefs or conflicts with traditionally masculine attributes. Using social cognitive theory and social role theory, this study conducted a cross-sectional survey on parents of children aged 9 through 16. Positive relationships existed between outcome expectations, self-efficacy, and level of detail in sexual and reproductive health conversations between parents and children. Though no statistical difference was …

Common Aav Gene Therapy Vectors Show Nonselective Transduction Of Ex Vivo Human Brain Tissue, J P Mcginnis, Joshua Ortiz-Guzman, Maria Camila Guevara, Sai Mallannagari, Benjamin D W Belfort, Suyang Bao, Snigdha Srivastava, Maria Morkas, Emily Ji, Angela Addison, Evelyne K Tantry, Sarah Chen, Ying Wang, Zihong Chen, Kalman A Katlowitz, Jeffrey J Lange, Melissa M Blessing, Carrie A Mohila, M Cecilia Ljungberg, Guillermo Aldave, Ali Jalali, Akash Patel, Sameer A Sheth, Howard L Weiner, Shankar Gopinath, Ganesh Rao, Akdes Serin Harmanci, Daniel J Curry, Benjamin R Arenkiel

Children’s Nutrition Research Center Staff Publications

The ability to deliver a therapeutic sequence to a specific cell type in the human brain would make possible innumerable therapeutic options for some of our most challenging diseases; however, studies on adeno-associated virus (AAV) vector tropism have generally relied on animal models with limited translational utility. For this reason, establishing the tropism of common adeno-associated virus (AAV) vectors in living human brain tissue serves as an important baseline for further optimization, as well as a determination of human brain cell types transduced by clinically approved gene therapy vectors AAV2 and AAV9. We have adapted an

Revising And Consolidating The Dsm-5 And Icd-11 Post-Traumatic Stress Disorders Into A Dimensional Spectrum-Based Disorder: A Literature Review, Samuel Milton Shatsky

University Honors Theses

This thesis investigates the clinical, cultural, and theoretical implications of replacing the current DSM-5 and ICD-11 categorical diagnoses of posttraumatic stress disorder (PTSD) and complex posttraumatic stress disorder (CPTSD) with a unified dimensional framework: trauma spectrum disorder (TSD). The proposed TSD model addresses ongoing concerns around diagnostic inflation, treatment misalignment, and clinical confusion stemming from binary trauma categorizations. This thesis explores whether adopting a dimensional diagnostic model to replace DSM-5 and ICD-11's current PTSD and CPTSD designations could lead to improved treatment outcomes and diagnostic clarity.

Methodology consisted of an extensive literature review of the field's current research. Using the …

Evaluation Of Aav Vectors With Tissue-Specific Or Ubiquitous Promoters In A Mouse Model Of Mucopolysaccharidosis Type Iva, Shaukat A. Khan, Jose Victor Álvarez, F. N. U. Nidhi, Eliana Benincore-Florez, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis type IVA (MPS IVA) is caused by a deficiency of N-acetyl-galactosamine-6-sulfate sulfatase (GALNS), leading to the accumulation of keratan sulfate and chondroitin-6-sulfate and development of severe skeletal dysplasia. Enzyme replacement therapy and hematopoietic stem cell transplantation are current treatment options but have limited impact on bone lesions. In this study, we investigated adeno-associated virus (AAV)8 or AAV9 vectors with liver-specific thyroxine-binding globulin or liver-specific promoter-a modification of hAAT (LSPX), liver-muscle tandem (LMTP), liver-bone tandem (LBTP), and ubiquitous cytomegalovirus early enhancer/chicken β-actin (CAG) promoters in MPS IVA mice to compare therapeutic efficacy on biochemical markers and bone pathology. All vectors …

Development Of Novel Force Fields For Metal Ions, Madelyn Smith

Dissertations

Many biological proteins require the presence of a metal ion in order to properly function. However, metal ions’ complex nature charge poses several challenges to accurately and efficiently simulate computationally. For example, metal ions can exhibit multiple oxidation states, electronic state degeneracy, flexible coordination numbers, and significant polarization effects. To address these problems, this dissertation aims to enhance force fields for modeling metal ions in molecular dynamics simulations. First, a comprehensive set of van der Waals radii for metal ions is derived, demonstrating the importance of using physically meaningful parameters in force fields. Second, a comprehensive set of atomic and …

Nist Recent Advances In Support Of Radiometric Calibrations, Michelle Stephens

The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)

No abstract provided.

Developing A Consistent And Coordinated Response From The National Metrology Institutes’ Radiometry Community To The Needs Of The Earth Remote Sensing Satellite-Observation Communities, Michelle Stephens, Emma Wolliams

The Characterization and Radiometric Calibration for Remote Sensing Annual Meeting (CALCON)

Modern satellite-based Earth observation measurements demand long-term data records that span multiple missions with reduced uncertainties. SI-traceability and robust uncertainty analyses are key aspects to meeting these demanding requirements. In this presentation we report on the activities of the CCPR-WG-SP TG17, an international task force created within the Bureau International des Poids et Mesures (BIPM) to provide a consistent and coordinated response from the National Metrology Institute (NMI) radiometry community to the needs of the satellite-observation communities.

The BIPM is the international organization through which National Metrology Institutes work together on matters related to metrology. Within the BIPM, the Consultative …

Topological Indices For The Resize Graph Of (G2(3)), Manar Musab Ftekhan, Ali Abd Aubad

Iraqi Journal for Computer Science and Mathematics

Indexes of topological play a crucial role in mathematical chemistry and network theory, providing valuable insights into the structural properties of graphs. In this study, we investigate the Resize graph of G₂(3), a significant algebraic structure arising from the exceptional Lie group (G₂) over the finite field F₃. We compute several well-known topological indices, including the Zagreb indices, Wiener index, and Randić index, to analyze the graph's connectivity and complexity. Our results reveal intricate relationships between the algebraic structure of G₂(3) and its graphical properties, offering a deeper understanding of its combinatorial …