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The Efficacy Of Open Educational Resources On Achievement Outcomes In Different Higher Education Institutions, Angela Grace Findlay Jun 2025

The Efficacy Of Open Educational Resources On Achievement Outcomes In Different Higher Education Institutions, Angela Grace Findlay

Theses and Dissertations

Students suffer from achievement gaps in higher education. Achievement gaps refer to differences in graduation rates, retention rates, persistence rates, and student's grades. Achievement gaps may negatively affect students who are culturally or ethnically diverse and/or have a lower socioeconomic status. The use of open educational resources (OER) may mitigate achievement gaps as OER assists student success through higher academic performance and cost savings for students. Average quiz scores were obtained at different higher education institutions using an Introduction to Psychology OER. The scores from each course were analyzed using hierarchical linear modeling. Colleges were nested by demographics to evaluate …


Measuring What Matters To Patients: A Multiple Methods Sequential Study Of Disease Burden, Quality Of Life, And The Alignment Of Patient-Reported Outcome Measurements For High-Risk Myelodysplastic Syndrome And Acute Myelogenous Leukemia Patients, Anthony J. Messina Jun 2025

Measuring What Matters To Patients: A Multiple Methods Sequential Study Of Disease Burden, Quality Of Life, And The Alignment Of Patient-Reported Outcome Measurements For High-Risk Myelodysplastic Syndrome And Acute Myelogenous Leukemia Patients, Anthony J. Messina

Doctor of Philosophy in Translational Health Sciences Dissertations

Background

High-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are aggressive hematologic malignancies with poor prognoses, where extending survival often comes at the cost of substantial morbidity. This study was grounded in the quality of survival (QoS) framework, which emphasizes that treatment outcomes should balance longevity with the health-related quality of life (HRQoL) experienced during the period of survival. In this context, patient-reported outcomes are crucial to capturing what truly matters to patients. However, existing patient-reported outcome measures (PROMs) used in MDS/AML clinical trials may not fully reflect patient priorities. A complementary Wilson–Cleary model perspective, linking biological factors to …


Report On 2024-2025 Compliance With Continuous Quality Improvement Legislation, University Of Northern Iowa Jun 2025

Report On 2024-2025 Compliance With Continuous Quality Improvement Legislation, University Of Northern Iowa

Institutional Effectiveness & Planning Documents

A report provided to the Iowa Board of Regents regarding continuous improvement processes in courses at the University of Northern Iowa.


Rethinking “Key-Chain Swap” And Other Decontextualized Algorithm Teaching Practices For Rational Number Learners, Connor B. Desai Jun 2025

Rethinking “Key-Chain Swap” And Other Decontextualized Algorithm Teaching Practices For Rational Number Learners, Connor B. Desai

Education Dissertations

Mathematical literacy is critical in an increasingly data-driven society, yet many students struggle with rational number concepts due to the prevalence of decontextualized algorithmic instruction. This study investigates the impact of targeted professional development (PD) on sixth-grade teachers’ instructional strategies and their students’ rational number achievement. The research examines whether explicit, conceptually grounded teaching of rational number operations improves student understanding compared to traditional algorithm-based instruction. Using a mixed-methods approach, the study collected quantitative and qualitative data from students at two middle schools. The intervention was statistically significant at School A, where students in the intervention group demonstrated greater achievement …


Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li Jun 2025

Human Gut Commensal Alistipes Timonensis Modulates The Host Lipidome And Delivers Anti-Inflammatory Outer Membrane Vesicles To Suppress Colitis In An Il10-Deficient Mouse Model, Ethan Older, Mary K. Mitchell, Andrew Campbell, Xiaoying Lian, Michael Madden, Yuzhen Wang, Lauren E. Van De Wal, Thelma Zaw, Brandon N. Vanderveen, Rodney Tatum, E. Angela Murphy, Yan-Hua Chen, Daping Fang, Melissa Ellermann, Jie Li

Faculty Publications

Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied, and the underlying molecular mechanisms remain unknown. In this study, colonization of Il10-deficient mice with Alistipes timonensis DSM 27924 delays colitis development. Colonization does not significantly alter the gut microbiome composition, but instead shifts the host plasma lipidome, increasing phosphatidic acids while decreasing triglycerides. Outer membrane vesicles (OMVs) derived from Alistipes are detected in the plasma of colonized mice, carrying potentially immunomodulatory metabolites into the …


Legal Geographies Of Mapuche-Williche Ancestral Waters: Real Estate Development And Contested Jurisdiction In Riparian Areas, Adamari Benavidez Jun 2025

Legal Geographies Of Mapuche-Williche Ancestral Waters: Real Estate Development And Contested Jurisdiction In Riparian Areas, Adamari Benavidez

Geography Undergraduate Senior Theses

In the Wallmapu (ancestral Mapuche territory) of southern Chile, river and lakefront real estate development is often promoted by state institutions and developers as conservation or eco-tourism. However, these inmobiliaria projects are part of a longer trajectory of settler colonial jurisdiction, historically materialized through the dispossession of Mapuche-Williche territory. In the Maihue–Ranco subwatershed, this encroaching development are sparking increasing conflict with Mapuche-Williche lof (community), as developers and residents engage in extralegal practices—diverting waterways, denying access to lakefronts, surveilling mobility—that are fundamentally incompatible with Mapuche territorial order (Azmapu).

In this thesis I ask: (i) What spatial and legal strategies …


Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković Jun 2025

Insights Into The Floral Senescence Effects Of Nanoparticles, Vuk Uskoković

Administration and Staff Articles and Research

Flowers could be valuable addenda to nanomedicine labs as in vivo models crossing the gap between the cell culture and small mammals. However, as it is shown here, floral models continue to be predominantly utilized within resource-limited research environments and remain largely underrepresented in mainstream biomedical investigations conducted by well-funded institutions in the developed world. The ability to delay the senescence of Orange Jubilee wildflowers was tested here on three types of nanoparticles: selenite-doped hydroxyapatite (HAp), citrate-stabilized HAp, and superparamagnetic iron oxide. Integration of selenite into the HAp crystal lattice produced a mild increase in the senescence rate …


Ocean Acidification Decreases Molting But Not Survival Of Antarctic Amphipods Djerboa Furcipes, Gondogeneia Antarctica, And Prostebbingia Gracilis, Hannah E. Oswalt, Margaret O. Amsler, Charles D. Amsler, Julie Schram, James B. Mclintock, Paul A. Baker Jun 2025

Ocean Acidification Decreases Molting But Not Survival Of Antarctic Amphipods Djerboa Furcipes, Gondogeneia Antarctica, And Prostebbingia Gracilis, Hannah E. Oswalt, Margaret O. Amsler, Charles D. Amsler, Julie Schram, James B. Mclintock, Paul A. Baker

Faculty, Staff, and Students

Ocean acidification refers to a decrease in the pH of the world’s oceans from the oceanic uptake of human-derived atmospheric CO2. Low pH is known to decrease the calcification and survival of many calcifying invertebrates. Shallow, hard bottom communities along the Western Antarctic Peninsula often have incredibly large numbers of invertebrate mesograzers that shelter on and are mutualists with the dominant brown macroalgae. The common amphipod species Djerboa furcipes, Gondogeneia antarctica, and Prostebbingia gracilis were collected from the immediate vicinity of Palmer Station, Antarctica (64°46′S, 64°03′W) in January–February 2023 and maintained under three different pH treatments simulating ambient conditions (approximately …


More Equal Than Others: Taxonomic Bias In Animal Management, Barrett L. Christie Jun 2025

More Equal Than Others: Taxonomic Bias In Animal Management, Barrett L. Christie

Animal Sentience

Oldfield & Bonano (2024) point out not only the scarcity of research on fish welfare but also significant taxonomic bias in broader research on these species. This bias extends to the management practices of aquaria and zoos, where the focus is on higher vertebrates. More resources need to be allocated to research to address this disparity. We also need to develop welfare constructs that recognize the inherent differences between aquatic and terrestrial species, taking into account the unique ecological contexts and behavioral patterns of fishes.


Is Education Regulation The Solution To Help Lower Substance Use Rates And Substance Use Disorder In Oregon Youth?, Sophia R. Swain Jun 2025

Is Education Regulation The Solution To Help Lower Substance Use Rates And Substance Use Disorder In Oregon Youth?, Sophia R. Swain

Hatfield Graduate Journal of Public Affairs

How can we lower Oregon’s youth substance use disorder (SUD) and overdose rates? Oregon is third in the country for SUD, with 5.77% of adolescents (12-17) having documented SUD. Some claim that it is because of the decriminalization of drugs, like Senator Art Robinson, but another reason relies on how we are educating Oregon youth. Oregon education standards outline requirements for drug and alcohol education as well as Senate Bill 238. By analyzing school districts current prevention programs in high overdose-rate counties (Multnomah, Lane, and Josephine) and low overdose-rate counties (Washington, Yamhill, Linn, Deschutes, Marion, and Clackamas), a lack of …


A Veblenian Approach To Chaos Theory, Isaiah Henry Jun 2025

A Veblenian Approach To Chaos Theory, Isaiah Henry

Hatfield Graduate Journal of Public Affairs

This paper provides a comparative analysis of Veblen's belief in disequilibrium, the field of chaos theory, and how these two frameworks connect. We explore the similarities and differences between Veblen's theories and the principles of chaos theory, including their shared emphasis on complexity and unpredictability. By analyzing the connections between Veblen's economic theories and chaos theory, we can gain a deeper understanding of the nature of disequilibrium and the complex forces that shape our world.


One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal Jun 2025

One Health Integration To Control And Prevent Zoonoses: Application Of Organizational Theory Literature, Lisset M. Dumet Poma, Sherril Gelmon, Julia M. Goodman, Seth E. O’Neal

Hatfield Graduate Journal of Public Affairs

Zoonoses are infectious diseases transmitted between animals and people that disproportionately affect low- and middle-income countries (LMICs). The One Health (OH) approach aims to integrate systems, incentivizing collaboration among animal, human, and environmental systems to address zoonoses and improve health. Innovative solutions for effectively and sustainably achieving systems integration are needed. Organizational theories can facilitate the study of the context of OH implementation, applying comprehensive approaches that recognize the interconnections among organisms, the environment, and social systems, including the diverse entities needing integration (e.g., policy, community, public organizations). This narrative review examines organization and systems literature to provide recommendations for …


Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin Jun 2025

Gen Z Hybristophilia: The Role Of Tiktok In Young Women’S Attraction To Deviant Men, Emma Virginia Treggia, Maria Ioannou, Calli Tzani, David Lester, Lucas Rogers, Thomas James Vaughan Williams, John Synnott, Michelle Drouin

Health Services and Informatics Research

This research explores hybristophilia (an individual’s sexual interest in and attraction to those who commit crimes) among Generation Z women, particularly through investigating how Gen Z female users interact with and feel about hybristophilic content and how this content impacts their attraction to offenders. Study 1 involved a content analysis of 66 videos and 91 comments on TikTok, identifying seven main themes: The Halo Effect, Actor-Offender Transference, Sympathy, Romance and APD, Protection and Loyalty, “I Can Fix Him,” Gen Z Irony, and Victim Fantasy. Study 2 used a cross-sectional survey with 95 women aged 18–27 to measure exposure to and …


Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos Jun 2025

Leveraging An Arts-Based Approach To Foster Engagement, Nurture Kindness, And Prevent Violence, Yok-Fong Paat, Diego Garcia Tovar, Nathan W. Myers, Max C. E. Orezzoli, Anne M. Giangiulio, Sarah L. Ruiz, Angela V. Dorado, Luis R. Torres-Hostos

School of Social Work Faculty Publications

Drawing from the insights of community partners, this study explored the roles and benefits of arts-based approaches to foster civic learning, critical media literacy, and community engagement. It also uncovered approaches to promote kindness, prevent violence, and combat online extremism, offering insights into strategies that may enhance community engagement and create a positive impact. We presented our model framework, a detailed case study of our project, and qualitative methods incorporating 15 interviews with our community partners to capture a broad range of perspectives and experiences. Interviewees were community partners who collaborated with our project in organizing events and activities using …


Olfaction And Plasma Biomarkers Of Alzheimer Disease And Neurodegeneration In The Atherosclerosis Risk In Communities Study, Srishti Shrestha, Xiaoqian Zhu, Michael E Griswold, Priya Palta, Kevin J Sullivan, Honglei Chen, Andrea Lauren Christman Schneider, Abhay Moghekar, Megan L Grove, Bharat Thyagarajan, James Russell Pike, Rebecca F Gottesman, B Gwen Windham, Thomas H Mosley, Jennifer A Deal, Vidyulata Kamath Jun 2025

Olfaction And Plasma Biomarkers Of Alzheimer Disease And Neurodegeneration In The Atherosclerosis Risk In Communities Study, Srishti Shrestha, Xiaoqian Zhu, Michael E Griswold, Priya Palta, Kevin J Sullivan, Honglei Chen, Andrea Lauren Christman Schneider, Abhay Moghekar, Megan L Grove, Bharat Thyagarajan, James Russell Pike, Rebecca F Gottesman, B Gwen Windham, Thomas H Mosley, Jennifer A Deal, Vidyulata Kamath

Faculty, Staff and Student Publications

Background and objectives: Investigation of olfactory impairment, an early manifestation of Alzheimer disease (AD), in relation to plasma biomarkers of AD and neurodegeneration could provide insights into the disease's pathophysiology. Because few such studies based on large, diverse, community-based populations exist, we investigated associations of odor identification ability with plasma biomarkers of AD and other neurodegenerative pathologies in community-dwelling Black and White older adults.

Methods: This cross-sectional investigation included participants from the Atherosclerosis Risk in Communities study who attended visit 5 (2011-2013) and who completed olfactory testing and brain MRI examinations and had plasma biomarkers measured (namely, amyloid-beta [Aβ]42/Aβ40 ratio, …


Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng Jun 2025

Structural Basis For The Substrate Specificity Of Helix Pomatia Amp Deaminase And A Chimeric Adgf Adenosine Deaminase, Gundeep Kaur, John R Horton, George Tzertzinis, Jujun Zhou, Ira Schildkraut, Xiaodong Cheng

Faculty, Staff and Student Publications

Helix pomatia AMP deaminase (HPAMPD), an enzyme enriched in the foot muscle of the mollusk H. pomatia, exhibits deaminase activity on adenosine-5'-monophosphate (AMP). HPAMPD is the first member of the adenosine deaminase-related growth factor (ADGF) family to prefer the nucleotide AMP over the nucleoside adenosine. To investigate the substrate selectivity of HPAMPD, we determined its structure in both the apo form and in complex with the adenosine analogs pentostatin and pentostatin-5'-monophosphate. Structurally, HPAMPD adopts a fold similar to human ADA2, an ADGF family member. HPAMPD has acquired the ability to interact with the 5'-monophosphate group of AMP through polar and …


Engineering Lipid–Polymer Nanoparticles For Sirna Delivery To Cancer Cells, Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi Jun 2025

Engineering Lipid–Polymer Nanoparticles For Sirna Delivery To Cancer Cells, Arthur Manda, Abdulelah Alhazza, Hasan Uludağ, Hamidreza Montazeri Aliabadi

Pharmacy Faculty Articles and Research

Background: RNA interference (RNAi) is a powerful tool that can target many proteins without the expensive and time-consuming drug development studies. However, due to the challenges in delivering RNA molecules, the potential impact of RNAi approaches is yet to be fully realized in clinical settings. Lipid nanoparticles (LNPs) have been the most successful delivery system for nucleic acids, but targeted delivery to a solid tumor still eludes the developed LNPs. We hypothesized that specially designed low-molecular-weight PEIs can partially or completely replace the ionizable lipids for more accommodating vehicles due to the structural flexibility offered by polymers, which could …


Exploring The Lived Experiences Of Rural Women Of Color Seeking Police Intervention During An Intimate Partner Violence Crisis, Michelle Angelica Perez Jun 2025

Exploring The Lived Experiences Of Rural Women Of Color Seeking Police Intervention During An Intimate Partner Violence Crisis, Michelle Angelica Perez

Walden Dissertations and Doctoral Studies

Exploring the lived experiences of rural women of color in the United States who seek police intervention during an intimate partner violence crisis is a necessity. In rural regions, many African American and Caribbean Blacks in rural communities endure physical assaults perpetrated by their partners throughout their lives. IPV among women of color, especially the obstacles that they face in requesting police intervention. The findings of this research study provide valuable insights that can support the establishment of intervention centers for rural women of color by involving key stakeholders, such as police departments in these regions. This study used semi-structured …


Hematopoietic Stem Cell Transplantation Outcomes For High-Risk Aml: A Report From The Children's Oncology Group., Benjamin J. Huang, Lauren K. Meyer, Todd A. Alonzo, Yi-Cheng Wang, Adam J. Lamble, Rhonda E. Ries, Weijie Wang, Betsy Hirsch, Gordana Raca, Xiaotu Ma, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Todd M. Cooper, Katherine Tarlock, Michael R. Loken, Soheil Meshinchi, Joseph H. Chewning, William G. Woods, John T. Horan Jun 2025

Hematopoietic Stem Cell Transplantation Outcomes For High-Risk Aml: A Report From The Children's Oncology Group., Benjamin J. Huang, Lauren K. Meyer, Todd A. Alonzo, Yi-Cheng Wang, Adam J. Lamble, Rhonda E. Ries, Weijie Wang, Betsy Hirsch, Gordana Raca, Xiaotu Ma, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Todd M. Cooper, Katherine Tarlock, Michael R. Loken, Soheil Meshinchi, Joseph H. Chewning, William G. Woods, John T. Horan

Manuscripts, Articles, Book Chapters and Other Papers

PURPOSE: Hematopoietic stem cell transplantation (HSCT) is used as consolidation for pediatric patients with high-risk AML in first complete remission (CR1). The definition of high-risk AML has evolved considerably over the past two decades with the successive identification of new unfavorable risk factors. We conducted a cross-study analysis to determine whether HSCT improves the outcomes of patients with contemporarily defined high-risk AML.

METHODS: We combined data from AAML0531 and AAML1031, the last two phase III clinical trials completed by the Children's Oncology Group (COG). These two trials established the prognostic importance of measurable residual disease (MRD) and several high-risk cryptic …


Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang Jun 2025

Loss Of Methyltransferase And Hypomethylated M6a Sarcomere Transcripts Leading To Early-Onset Dilated Cardiomyopathy, Sophie Marie Hand, Yi Zhao, Donna Li, Savanna Burke, Hee-Woong Lim, Jessie Yester, Vidu Garg, Federica Accornero, Xiao Li, Deqiang Li, Jihyun Jang

Faculty, Staff and Students Publications

No abstract provided.


Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, Ruvandhi R Nathavitharana, Tobias Broger, Ioana Diana Olaru, Brittney Sweetser, Hayley Poore, Alia Razid, Alexander W Kay, Claudia M Denkinger, Ian Schiller, Nandini Dendukuri, Devan Jaganath, Andreas Lundh, Maunank Shah Jun 2025

Parallel Use Of Low-Complexity Automated Nucleic Acid Amplification Tests And Lateral Flow Urine Lipoarabinomannan Assays To Detect Tuberculosis Disease In Adults And Adolescents Living With Hiv, Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, Ruvandhi R Nathavitharana, Tobias Broger, Ioana Diana Olaru, Brittney Sweetser, Hayley Poore, Alia Razid, Alexander W Kay, Claudia M Denkinger, Ian Schiller, Nandini Dendukuri, Devan Jaganath, Andreas Lundh, Maunank Shah

Faculty, Staff and Students Publications

Background: Low-complexity automated nucleic acid amplification tests (LC-aNAATs) are molecular World Health Organization (WHO)-recommended rapid diagnostic tests (also known as mWRDs) widely used to diagnose tuberculosis disease. The lateral flow urine lipoarabinomannan assay (LF-LAM) is recommended by the WHO to assist in diagnosing tuberculosis disease amongst people with HIV. Previous systematic reviews have assessed the diagnostic accuracy of LC-aNAATs and LF-LAM used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM).

Objectives: To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory …


Churchill House, L.P. V. Marshall Jun 2025

Churchill House, L.P. V. Marshall

All Decisions

In a licensee holdover involving a HUD Section 236/Low Income Housing Tax Credit apartment, the court dismissed the respondent's succession claim, granting the landlord a final judgment of possession and money judgment for use and occupancy. The court acknowledged that federal regulations and caselaw for subsidized apartments do not mandate the fixed co-residency periods of rent-regulated contexts nor require inclusion on household compositions. However, the respondent's testimonial evidence of co-residency with her deceased father for "a suitable duration" to establish membership in the family unit was found lacking in credibility and consistency, failing to prove her succession rights.


Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim Jun 2025

Application Of Claims-Based Frailty Index To A Structured Electronic Health Record Data, Min Ji Kwak, Caroline Schaefer, Youngran Kim, Sunyang Fu, Chan Mi Park, Abhijeet Dhoble, Nahid Rianon, Holly M Holmes, Dae Hyun Kim

Faculty, Staff and Student Publications

Background: The Claims-based Frailty Index (CFI) has been developed and validated using Medicare claims data. However, whether CFI can be applied to structured electronic health record data has not been studied.

Methods: We applied the CFI to a structured electronic health record dataset (Explorys dataset) and a Medicare fee-for-service 5% sample data and compared the prevalence of frailty from each dataset, using the cohort of older adults. Then, we assessed the odds ratio and area under the curve of the frailty predicting adverse clinical outcomes, any hospital or emergency room visit, or any adverse drug events related encounter within 1 …


Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin Jun 2025

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8+ T cells in the tumor microenvironment is key to improving cancer immunotherapy. Individuals with sickle cell disease (SCD), the most prevalent inherited blood disorder, have a higher risk of developing certain cancers than the general population, but the mechanisms driving this increased risk remain unclear. Our study revealed that SCD altered CD8+ T cell 3D genome architecture, triggering ferroptosis and weakening anti-tumor immunity, thereby promoting tumor growth. Using murine and humanized SCD models, we found that disrupted chromosomal interactions in CD8+ T cells reduced the expression of anti-ferroptotic genes, including SLC7A11 and hydrogen sulfide …


Real-World Outcomes For Young Adult Patients Receiving Cd19 Car T-Cell Therapy., Hannah Lust, Liora M. Schultz, Soyang Kwon, Gregory W. Roloff, Ibrahim Aldoss, Christina Baggott, Samuel John, Jenna E. Rossoff, Kevin O. Mcnerney, Vanessa A. Fabrizio, Julie-An Talano, Amy Moskop, Kevin J. Curran, Christine L. Phillips, Nicole Karras, Susanne H C Baumeister, Stacy L. Cooper, Michelle Hermiston, Prakash Satwani, Muna Qayed, Sunil S. Raikar, Margaret Macmillan, Erin Hall, Khanh Nguyen, Ryan D. Cassaday, Noam E. Kopmar, Vamsi K. Kota, John Mathews, Paul Shaughnessy, Marc S. Schwartz, Abdullah Ladha, George Yaghmour, Muthu V. Kumaran, Veronika Bachanova, Sean Tracy, Tamer Othman, Marlise R. Luskin, Evan C. Chen, Anjani S. Advani, Nikeshan Jeyakumar, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Bijal D. Shah, Lori Muffly, Rawan Faramand Jun 2025

Real-World Outcomes For Young Adult Patients Receiving Cd19 Car T-Cell Therapy., Hannah Lust, Liora M. Schultz, Soyang Kwon, Gregory W. Roloff, Ibrahim Aldoss, Christina Baggott, Samuel John, Jenna E. Rossoff, Kevin O. Mcnerney, Vanessa A. Fabrizio, Julie-An Talano, Amy Moskop, Kevin J. Curran, Christine L. Phillips, Nicole Karras, Susanne H C Baumeister, Stacy L. Cooper, Michelle Hermiston, Prakash Satwani, Muna Qayed, Sunil S. Raikar, Margaret Macmillan, Erin Hall, Khanh Nguyen, Ryan D. Cassaday, Noam E. Kopmar, Vamsi K. Kota, John Mathews, Paul Shaughnessy, Marc S. Schwartz, Abdullah Ladha, George Yaghmour, Muthu V. Kumaran, Veronika Bachanova, Sean Tracy, Tamer Othman, Marlise R. Luskin, Evan C. Chen, Anjani S. Advani, Nikeshan Jeyakumar, Katharine Miller, Amy Zhang, Katherine C. Sutherland, Bijal D. Shah, Lori Muffly, Rawan Faramand

Manuscripts, Articles, Book Chapters and Other Papers

Tisagenlecleucel (tisa-cel) and brexucabtagene autoleucel (brexu-cel) are approved CD19 chimeric antigen receptor T-cell therapy (CAR T) products for young adults (YA) with relapsed/refractory B-cell acute lymphoblastic leukemia. A distinct analysis of YAs receiving commercial CD19 CAR T has not been reported. Using retrospective data from the Pediatric Real-World CAR T Consortium and the Real-World Outcomes of CAR T in Adult ALL collaboration, we describe the efficacy and safety of tisa-cel and brexu-cel in 70 YAs (18-26 years; tisa-cel, n = 50; brexu-cel, n = 20). Cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were observed more frequently …


Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma Jun 2025

Arid4b: An Orchestrator From Stem Cell Fate To Carcinogenesis, Rakhee Rathnam Kalari Kandy, Madan Kumar Arumugam, Mukesh Pratap Yadav, Bibhuti Bhusan Mishra, Jyotika Sharma

Faculty, Staff and Student Publications

All biological processes, from embryonic development to cancer, are tightly controlled by the interactions between genetics and epigenetics. An array of epigenetic modifications, such as DNA methylation, histone/chromatin modifications, and noncoding RNA-mediated targeting, are essential to regulate the heritable changes that occur during multiple cellular processes. A failure in proper regulation results in inappropriate gene expression that ultimately leads to pathological states. Groundbreaking advances in genomics and transcriptomics have revealed the potential involvement of epigenetics in various physiological and pathological states. The promising clinical and preclinical results shown by epigenetics drugs further underscore the central role of epigenetics in multiple …


Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin Jun 2025

Sickle Cell Disease Induces Chromatin Introversion And Ferroptosis In Cd8+ T Cells To Suppress Anti-Tumor Immunity, Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Faculty, Staff and Student Publications

Understanding how genetic disorders affect CD8


Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers Jun 2025

Toward Culturally Responsive Interpretation: Native American Histories, Lifeways, And Ways Of Knowing At The High Desert Museum, Carol Fitzsimmons, Ajena Cason Rogers

Dissertations

Many public museums and historic institutions reflect settler colonial culture and are primarily non-Native led. Although these institutions are trusted, many have perpetuated cultural harm through the theft of belongings, the misrepresentation of stories and histories, and the inaccurate portrayals of cultural content. When interpreting Native American experiences, many non-Native institutions struggle to co-create culturally responsive interpretation. The purpose of this basic qualitative study was to apply the four-truth framework, developed by the South African Truth and Reconciliation Commission, to better understand how the High Desert Museum approached the interpretation of Native American content and stories and to explore how …


Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown Jun 2025

Modeling And Simulation Of Tensegrity Structures With Continuous Cables, Austin R. Brown

Theses and Dissertations

This thesis presents a novel approach for modeling and simulating tensegrity structures with continuous cables. A Python-based simulation framework package was developed to address limitations in existing tensegrity modeling software, particularly the inability to model cables passing through multiple nodes. The framework utilizes virtual work methods to solve for equilibrium configurations of 2D, 2.5D and 3D tensegrity systems. Key features include: • A YAML-based input system for easy definition of tensegrity topologies. • Algorithms for handling continuous cables spanning multiple nodes. • Optimization techniques to find stable equilibrium states. • Capability to simulate 2.5D structures wrapped around cylindrical surfaces. • …


Securing Americans' Genetic Information: Privacy And National Security Concerns Surrounding 23andme's Bankruptcy Sale. Hearing Before The House Committee On Oversight And Government Reform, United States House Of Representatives, 119th Congress, First Session., Margaret Hu Jun 2025

Securing Americans' Genetic Information: Privacy And National Security Concerns Surrounding 23andme's Bankruptcy Sale. Hearing Before The House Committee On Oversight And Government Reform, United States House Of Representatives, 119th Congress, First Session., Margaret Hu

Congressional Testimony

No abstract provided.