Digital Commons Network^™

Research Progress On Methods For Evaluating The Effect Of Milk Desensitization, Xu Chenyu, Lu Dingqiang, Wang Qian, Li Ming, Wu Wenling, Song Qingwei

Food and Machinery

Food allergies are becoming an increasingly serious issue,and milk,as one of the major allergens,severely affects the daily lives of individuals with allergies.This article reviews the recent research progress on methods for assessing the desensitization of milk allergenicity from the perspectives of protein structural changes,IgE/IgG binding capacity,animal sensitization models,in vitro digestion models,and cell degranulation assays.It also looks forward to the future directions of research on methods for evaluating the effectiveness of milk desensitization.

Gender-Based Crimes And The Colombian Special Jurisdiction For Peace, Caroline Davidson

Duke Journal of Comparative & International Law

The Special Jurisdiction for Peace ("JEP"), created as part of Colombia's historic 2016 Peace Agreement, has been hailed as a novel, restorative justice-oriented mechanism for addressing gross human rights violations at the domestic level. Commentators point to the JEP as a potential model for other jurisdictions looking to address mass atrocities. The success or failure of this model hinges on the JEP's ability to effectively address an issue of great concern to the International Criminal Court as well as to Colombian civil society: gender-based crimes. This Article is the first to examine comprehensively the JEP's progress on this vital issue, …

Reducing Attention Complexity In Graph Transformers Through Subgraph Partitioning, Ranjan Kumar Choubey

Master’s Dissertations

This dissertation addresses the challenge of scaling Graph Transformers by proposing a subgraph-based strategy to reduce attention complexity. The proposed framework preserves representational power while making attention computation tractable for largescale graphs. The method begins by partitioning the input graph into K subgraphs using the METIS algorithm. Each subgraph is encoded using a combination of local structural features from a Graph Convolutional Network (GCN) and global positional cues from Laplacian Positional Embeddings (LPEs). These embeddings are fused via a trainable projection function to form subgraph tokens. A supergraph is constructed to model interactions among subgraphs, allowing attention to be applied …

Some Results In Thermodynamic Formalism, C. Evans Hedges

Electronic Theses and Dissertations

This dissertation investigates several key questions at the intersection of dynamical systems, computability theory, and thermodynamic formalism. In the symbolic setting, we establish novel results regarding the statistical properties of equilibrium states, deriving bounds on probabilities of configurations and relating these bounds to the Gibbs property through the homoclinic relation. Additionally, we examine the computability of thermodynamic quantities such as pressure, ground state energy, and residual entropy. We show that topological pressure is computable from above for general subshifts and computable for strongly irreducible shifts, with similar results extending to ground state energy and residual entropy.

Extending beyond subshifts, we …

Sensing Protein Structural Transitions With Microfluidic Modulation Infrared Spectroscopy, Lathan Lucas, Phoebe S Tsoi, Ananya Nair, Allan Chris M Ferreon, Josephine C Ferreon

Faculty, Staff and Students Publications

Microfluidic modulation spectroscopy-infrared (MMS) offers a label-free, high-sensitivity approach for quantifying changes in protein secondary structures under native solution conditions. MMS subtracts the solvent backgrounds from sample signals by alternately flowing proteins and matched buffers through a microfluidic chamber, yielding clear amide I spectra from microliter volumes. In this study, we validated MMS on canonical globular proteins, bovine serum albumin, mCherry, and lysozyme, demonstrating accurate detection and resolution of α-helix, β-sheet, and mixed-fold structures. Applying MMS to the intrinsically disordered protein Tau, we detected environment-driven shifts in transient conformers: both the acidic (pH 2.5) and alkaline (pH 10) conditions increased …

Sustaining Queerness: A Phenomenological Study Of Colorado Educators, Devani Lemmon

Electronic Theses and Dissertations

The purpose of this study was to engage queer Colorado educators to explore how to sustain their identities as queer educators in a politically fractured state. By focusing on Colorado, I could assess the extent to which the legal protections afforded there adequately support educators in sustaining themselves. Additionally, the findings from Colorado had the potential to further illuminate factors influencing teacher sustainability and retention on a much larger scale. The questions for this research project were: 1) How are queer educators sustaining themselves and each other in an increasingly volatile political climate? 2) What, if any, factors impact queer …

Carbon Monoxide Releasing Polymeric Micelles, Riya Joshi

Electronic Theses and Dissertations

Carbon monoxide (CO), traditionally known as a toxic gas, has emerged as a potential therapeutic agent due to its cytoprotective, anti-inflammatory, and vasodilatory properties. This study explores the development of CO-releasing polymeric micelles as a controlled delivery system for biomedical applications. Using ring-opening metathesis polymerization (ROMP), we synthesized diblock copolymers incorporating CO-releasing moiety diphenylcyclopropenone (DPCP) with hydrophilic polyethylene glycol (PEG) to enhance solubility and stability of the overall CO releasing system. Dynamic light scattering (DLS) and electron microscopy (EM) confirmed the formation of well-defined micelles, while fluorescence assays demonstrated efficient CO release with the use of Iridium photocatalyst under 470 …

Survival Guide For Queer Families In Heteronormative Healthcare: Liberatory Consciousness And The Paradox Of Dependent Healthcare, A Critical Policy Discourse Analysis, Dwenna A. Holden

Electronic Theses and Dissertations

In this study I explored and analyzed how the queer experiences of an anonymous higher education institution in the western United States’ self-identified queer faculty and staff intersected with the discursive framing of the college’s dependent healthcare structure and documents. Within a critical paradigm I designed research around a high-density theoretical approach to weaving various branches of queer theory together with critical theory around policy and law in relation to queer bodies and hostile heteronormative policy environments. I arrived at solutions based in complaint, survival, and transformation. I used critical policy discourse analyses to interrogate the college’s dependent healthcare documents …

Cultivating Resilience In The Anthropocene: Evaluating A Gssw Ecological Justice Curriculum, Windy Selig

Electronic Theses and Dissertations

This Dissertation in Practice evaluated the University of Denver’s Graduate School of Social Work (GSSW) Ecological Justice Pathway to examine how resilience is conceptualized and cultivated within the curriculum. Grounded in a constructivist paradigm and guided by an ecological justice framework, this evaluation explored the pedagogical and curricular strategies designed to prepare social work students for the emotional, ethical, and professional demands of practicing in the Anthropocene—a time marked by ecological degradation, climate crisis, and compounding social inequities.

Through qualitative methods, including faculty interviews and curriculum document analysis, the evaluation identified both explicit and implicit components that foster student resilience. …

Young Adults’ Metaperceptions Of Their Childhood Caregivers’ Appraisals And Young Adulthood Mental Health, Cassandra Svelnys

Electronic Theses and Dissertations

Early experiences and relationships have enduring impacts on the development of self and later mental health and wellbeing. In social relationships and interactions, the developing individual is continuously assessing how they view themself, how they view the other person, and how they believe the other person views them. Metaperceptions represent the latter construct: how an individual thinks another person perceives them. Childhood self-esteem, parent-child attachment, and metaperceptions are foundational constructs for the developing individual, yet metaperceptions have not previously been tested as a predictor for adulthood mental health while also accounting for childhood self-esteem and parent-child attachment. This study introduced …

A Systematic Review And Meta-Analysis On The Role Of Somatostatin Therapy In Non-Variceal Gastrointestinal Bleeding, Magnus Chun, Tahne Vongsavath, Sneh Sonaiya, Lily Liu, Kyaw Min Tun, Kavita Batra, Robert G. Gish

Department of Internal Medicine Faculty Research

Background and Aims: Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common cause of hospitalizations, with proton pump inhibitors (PPIs) being the mainstay treatment. However, there is a lack of high-level evidence to show if adjunctive medical therapy (somatostatin and its analogs) can improve outcomes. This systematic review and meta-analysis aim to evaluate the outcomes of PPIs with adjunctive therapy versus PPI monotherapy in treating NVUGIB in an in-patient setting. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist, major databases were systematically searched to retrieve English-only, original studies, published from 1 January 2000 to 31 December …

Effect Of Ipv On Latino Children's Perspectives Of Fatherhood, Elizabeth Berks

University Honors Theses

Intimate partner violence (IPV) can be found in many cultures throughout the world, with varying levels of acceptability, victimization, and perpetration. Approximately one in five couples report experiencing at least one instance of IPV in a given year. Women are victims of IPV more frequently than men, and experience more severe injuries. 20% of women report a lifetime history of physical IPV victimization by their current or past partners. Further, women are also ten times more likely to be killed due to IPV than men are. Presently, empirical research literature surrounding the dynamics and impacts of IPV is heavily focused …

Mass Timber: The Future Of Sustainable Architectural Design, Julian Nychay

University Honors Theses

The current state of Mass Timber structures is in an interesting state at the moment; Mass Timber adoption has become a recent trend that has been taking place very recently. This is due to a number of factors, mainly the technology for mass timber has grown substantially, as well as human consciousness of our negative impact on the environment has led to a deep rethinking about how we build. In this paper, I examine what exactly mass timber is, why it is being used and what are the future and current benefits and challenges facing mass timber in modern design …

Investigating Hedgehog Signaling And Th17-Mediated Inflammation In Blau Syndrome: Insights Into Chronic Inflammation, Benjamin Volinski

University Honors Theses

Blau syndrome is a rare, monogenic inflammatory disorder caused by autosomal dominant mutations in NOD2, a cytosolic pattern recognition receptor that regulates immune signaling. Although traditionally considered an autoinflammatory disease driven by innate immune dysfunction, emerging evidence implicates T cells in Blau pathogenesis. Recent studies show that Nod2-deficient mice exhibit elevated IL-17A production despite normal TH17 differentiation, suggesting Nod2 regulates cytokine output independently of canonical lineage commitment. This study investigates how Nod2 mutations influence TH17-mediated inflammation and explores the role of Hedgehog (Hh) signaling, particularly the transcription factor Gli2, in this process.

Using the Nod2^R314Q/R314Q mouse model, …

The Intersection Of Education And Empowerment: How Comprehensive Sex Education Equips Adolescents To Navigate Complex Relational Dynamics, Joleigh Wood

University Honors Theses

This thesis examines the impact of comprehensive sex education (CSE) on adolescents' understanding of consent, personal boundaries, and relational competence. Drawing upon social learning theory, intersectionality, and relational-cultural theory, the study employs a multidisciplinary framework to analyze how CSE functions as both an instructional practice and a sociocultural intervention. Utilizing an integrative thematic review of empirical studies, policy analyses, and national curriculum standards, the research evaluates the extent to which CSE promotes emotional literacy, fosters ethical relationship skills, and addresses structural inequities in educational access. Findings indicate that well-implemented, inclusive CSE contributes to healthier developmental outcomes by enhancing students' emotional …

Longitudinal Relations Between Self-Esteem And Depression: A Continuous Time Analysis With Exploration Of Sleep Duration Effects, Mackenzie Cummings

Clinical Psychology Dissertations

Adolescents and young adults face elevated risk for depression. While poor self-esteem and sleep disturbance are known risk factors, few studies have examined their unique and interactive contributions. Longitudinal research often overlooks unequal intervals and multiple sources of variance (e.g., between- and within-person). This study used continuous time structural equation modeling to address these gaps and examine relationships between self-esteem, sleep duration, and depression from adolescence into adulthood. Drawing on four waves of data from the National Longitudinal Study of Adolescent to Adult Health (N = 6,184), I tested whether sleep duration moderated the self-esteem–depression link and explored gender differences. …

Understanding The Roles Of Individual And Family-Based Resilience Resources And Mechanisms In Youth With Painful Disorders Of Gut-Brain Interaction, Corinne Taylor Evans

All ETDs from UAB

Background Children living with chronic pain are at risk for many negative physical and mental health consequences. However, certain positive attributes and factors can help lessen or prevent such consequences. Children with painful disorders of gut-brain interaction (DGBIs) experience deficits in social, emotional, and physical functioning. However, it is unknown whether a combination of individual and family-based resilience factors may lower these risks and contribute to improved physical and mental health responses. Methods 120 children with painful DGBIs were recruited from a pediatric gastroenterology clinic. Children and caregivers completed a series of questionnaires measuring individual and family-based resilience resources (e.g., …

Investigating Momentary Body Image Disturbance, Affect, And Disordered Eating Among College Students, Allison T. Cunning

USF Tampa Graduate Theses and Dissertations

Despite evidence that eating disorders are associated with elevated mortality rates, increased risk of suicide, and societal and financial burden, treatment outcomes for individuals with eating disorders remain poor. Body image disturbance has emerged as a robust risk factor for the development and maintenance of disordered eating (e.g., overeating, binge eating, purging, restriction) and theoretical and clinical perspectives most commonly operationalize body image disturbance as a trait construct. However, empirical evidence suggests body dissatisfaction may fluctuate, and these fluctuations may play an important role in the relationship between risk factors and disordered eating. The current study employed ecological momentary assessment …

Roles Of Organic Agriculture For Water Optimization In Arid And Semi-Arid Regions, Shikha Sharma, Matt A. Yost, Jennifer R. Reeve

Plants, Soils and Climate Student Research

Water scarcity is a critical challenge in arid and semi-arid regions, where agricultural water consumption accounts for a significant portion of freshwater use. Conventional agriculture (CA) methods with high reliance on chemical and mechanical inputs often exacerbate this issue through soil degradation and water loss. This review aims to examine how different organic practices, such as mulching, cover cropping, composting, crop rotation, and no-till (NT) in combination with precision technologies, can contribute to water optimization, and it discusses the opportunities and challenges for the adoption and implementation of those practices. Previous findings show that organic agriculture (OA) may outperform CA …

Regulation Of Spermatogenesis By The Notch Signaling Pathway, Emma O'Flaherty

Master's Theses

The Notch signaling pathway plays a significant role in gonad development and spermatogenesis, but little is known about its specific targets in the testis. The Drosophila testis contains two populations of stem cells: germline stem cells and cyst stem cells, which give rise to differentiating germline and somatic cyst cells, respectively. Notch signaling is activated in the somatic cyst cells by the Delta ligand from the germline in a region of the testes coined the “transition zone”, where somatic cyst cells progress from early cyst cells surrounding gonialblasts and 2-cell germline cysts to late cyst cells surrounding 16-cell spermatocyte cysts. …

Integrated Metabolomics And Spatial Transcriptomics Of Cystic Pancreatic Cancer Precursors Reveals Dysregulated Polyamine Metabolism As A Biomarker Of Progression, Ricardo A León-Letelier, Yihui Chen, Rongzhang Dou, Ehsan Irajizad, Michele T Yip-Schneider, Ranran Wu, Rahmah Ejaz, Hamid K Rudsari, Yaxi Li, Rachelle Spencer, Riccardo Ballarò, Jody Vykoukal, Mark Hurd, Jennifer B Dennison, Kim-Anh Do, Anirban Maitra, Jianjun Zhang, Samir Hanash, C Max Schmidt, Johannes F Fahrmann

Faculty, Staff and Student Publications

Purpose: We conducted metabolomics and spatial cell transcriptomics of intraductal papillary mucinous neoplasms (IPMN), recognized pancreatic cancer precursors, to identify oncometabolites that inform upon risk of malignancy of IPMNs.

Experimental design: Untargeted metabolomic analyses were performed on cystic fluid from 125 patients with low-grade (LG) dysplasia or high-grade (HG) dysplasia with/without concurrent pancreatic ductal adenocarcinoma (PDAC; IPMN/PDAC). Predictive performance of individual metabolites for identifying HG or PDAC/IPMN was determined and compared with CA19-9 performance. Data were intersected with metabolic profiles of resected IPMN tissues and murine Kras;Gnas IPMN cell lines as well as spatial and single-cell transcriptomics of IPMNs.

Results: …

Azacitidine, Venetoclax, And Magrolimab In Newly Diagnosed And Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/Ii Study And Correlative Analysis, Naval Daver, Jayastu Senapati, Hagop M Kantarjian, Bofei Wang, Patrick K Reville, Sanam Loghavi, Musa Yilmaz, Courtney D Dinardo, Tapan M Kadia, Mhd Yousuf Yassouf, Abhishek Maiti, Sankalp Arora, Guillermo Montalban Bravo, Guilin Tang, Gautam Borthakur, Koji Sasaki, Naveen Pemmaraju, Joie Alvarez, Graciela M Nogueras Gonzalez, Jing Ning, Ghayas C Issa, Marina Konopleva, Michael Andreeff, Farhad Ravandi, Guillermo Garcia-Manero, Hussein A Abbas

Faculty, Staff and Student Publications

Purpose: Magrolimab is a monoclonal antibody directed against the macrophage checkpoint CD47 on myeloid leukemia cells that was preclinically synergistic with azacitidine-venetoclax, warranting further clinical evaluation.

Patients and methods: In this phase Ib/II study, the triplet combination of azacitidine, venetoclax, and magrolimab was evaluated in adult patients with first-line (ineligible for intensive chemotherapy) and relapsed/refractory acute myeloid leukemia. Azacitidine was dosed at 75 mg/m2 for 7 days, venetoclax at 400 mg/day for 28 days, and magrolimab (recommended phase II dose) as follows: 1 mg/kg dose on days 1 and 4, 15 mg/kg on day 8, and 30 mg/kg on days …

Comparative Effects Of Combustible Cigarette Versus Electronic Cigarette Exposures On Kras Mutant Lung Cancer Promotion, Walter V Velasco, Maria T Grimaldo, Nastaran Karimi, Michael J Clowers, Avantika Krishna, Ranran Wu, Rahmah Ejaz, Bo Yuan, Segundo Del Aguila, Iman Bouchelkia, Javier Eduardo Moreno Barragan, Katherine E Larsen, Yasmina Rezai, Farbod Khalaj, Kyler Mitra, Carlos Reyna Rodriguez, Ricardo Millares, Angelica Baca De Anda, Susana Castro-Pando, Umesh C Karandikar, Joseph F Petrosino, Florencia Mcallister, Humam Kadara, Edwin J Ostrin, Johannes F Fahrmann, Kristi Louise Hoffman, Seyed Javad Moghaddam

Center for Medical Ethics and Health Policy Staff Publications

Despite the emerging public health concern related to the use of electronic cigarette vapors (ECV), its impact on lung cancer is poorly understood. We assessed the effect of ECV on lung tumorigenesis in a mouse model of lung adenocarcinoma. Mice were exposed to either room air, combustible cigarette smoke (CCS), or ECV 2 hours daily for 8 weeks at which lung samples were harvested and studied for different outcomes. We found that CCS, but not ECV, led to a significant increase in tumor burden. Immunophenotyping of both CCS- and ECV-exposed lungs displayed pronounced pro-tumor immunosuppressive phenotypes, characterized by significantly decreased …

Dynamics Of Mangrove Carbon Stock In Selected Uae Coastline: A Remote Sensing Approach, Karthika Kandamkulathil Gopi

Thesis/ Dissertation Defenses

Mangrove ecosystems play a vital role in carbon sequestration by capturing atmospheric CO₂, storing it in aboveground and belowground biomass, and enhancing soil organic carbon (SOC) through litterfall. Arid mangrove ecosystems, such as those in the UAE, experience extreme environmental stressors, leading to distinct variations in biomass allocation and carbon stock estimates compared to tropical regions. This study aims to evaluate biomass accumulation, litterfall production, and SOC storage in selected UAE mangroves. It analyses seasonal litterfall dynamics and assesses the influence of bulk density, soil moisture, and tidal regimes on SOC and aboveground biomass (AGB) across distinct mangrove zones. Field-based …

The Anticancer Activity Of Novel Chromene Derivatives Against Colorectal Cancer Cells, Rym Magramane

Thesis/ Dissertation Defenses

Colorectal cancer (CRC) stands as the third most common cancer globally, accounting for nearly 10% of all newly diagnosed cancer cases. In the UAE, CRC was ranked as the third most frequently diagnosed malignancy, and the leading cause of cancer-associated deaths in 2023. Standard CRC treatment strategies include surgical resection, chemotherapy, immunotherapy, targeted therapy, or a combination of all, depending on the cancer stage and molecular profile. Despite these interventions, disease recurrence is experienced by a considerable number of cancer patients. Hence, there is an urgent need to develop novel alternative treatments to overcome poor prognosis. Recently, cancer research has …

Perceptions Of Exclusionary Discipline In Inclusive Classroom: A Phenomenological Study Of Middle School Co-Teachers’ Experience With Special Education Students Of Color, Tino Tomasi

Doctor of Education Program Dissertations

Exclusionary discipline practices in public middle schools disproportionately impact students of color in special education, disrupting their academic progress and social development. The purpose of this qualitative phenomenological study was to explore how public middle school co-teachers in inclusive classrooms perceive the use of exclusionary discipline for special education students of color. The study explored the lived experiences of eight public middle school co-teachers through three research questions: (1) How do public middle school co-teachers in inclusive classrooms perceive the use of exclusionary discipline for special education students of color? (2) How do public middle school co-teachers in inclusive classrooms …

Evaluation The Antibacterial Activity Of Cornulaca Moncantha Extract Against Multidrug Resistant Coagulase- Negative Staphylococci, Uday A.R. Hussein, Ayat H. Abd Al-Ameer, Tabark F. Abass, Haneen H. Abbas, Zahraa H. Jabbar, Fatima M.A. Alrasol, Mafaz G. Hassan, Mays A. Khaled

Al-Ameed Journal for Medical Research and Health Sciences

Background: Emergence of anti-microbial resistance represents a serious challenge to public health and the global economy, creating an urgent need for searching of new anti-microbial agents.

Objective: To investigate the antibacterial activity of Cornulaca moncantha ethanolic root extract against multidrug resistant coagulase-negative Staphylococci.

Material and Methods: The ethanolic extract of Cornulaca moncantha roots was prepared using a Soxhalet apparatus. Phytochemical screening was performed via standard qualitative tests (alkaloids with Mayer’s test, tannins with ferric chloride, flavonoids with Shinoda test, and saponins with foam test). The plant antibacterial activity as well as susceptibility of antibiotic against bacteria were evaluated using agar …

Piloted Autonomous Crisis Reconnaissance Robot 2.0 (Pacrr 2.0), Awawu Alimi, Urmika Ghosh, Marissa Kuo, Jonathan Santosa, Ethan Wyrick

Electrical and Computer Engineering Senior Theses

PACRR 2.0 (Piloted Autonomous Crisis Reconnaissance Robot, version 2) builds upon the original low-cost, autonomous-capable quadruped platform by enhancing both mobility and environmental perception for first-responder applications such as search and rescue, gas leak detection, and mapping of confined or hazardous areas. In PACRR 2.0, we integrate an RGB-D camera with analytic inverse kinematics and frame-based motion planning to achieve precise foot placement and stable quasi-static gaits even on sloped or uneven terrain. An NVIDIA Jetson processor runs high-level control and mapping alongside a Raspberry Pi 4 to manage motor control. Through simulation, we demonstrate robust 3D map generation and …

The New Right-Wing Populist: The Blonde “Mother Of The Nation”, Christina Charie

Political Science Undergraduate Theses

The rise of right-wing populism in European politics has come along side an increased presence of female representation in political affairs. What aesthetic decisions are being made by far-right female populist politicians? How do moderate right and left-wing women politicians differ in their presentation styles from populist women? While right-wing politics have gained traction in Europe before, this time women are the face of many right-wing populist movement, even though much of the ideology is rooted in misogyny and the presence of strong, masculine figureheads. With women taking center stage within these right-wing movements that are historically masculine, understanding their …

Decentralized Biobanking For Transparency, Accountability, And Engagement In Biospecimen Donation, Kennedy Sabharwal, Brian Hutler, M Eifler, Marielle Gross

Journal of Health Care Law and Policy

No abstract provided.