Digital Commons Network^™

Mic: A Deep Learning Tool For Assigning Ions And Waters In Cryo-Em And Crystal Structures, Laura Shub, Wenjin Liu, Georgios Skiniotis, Michael J Keiser, Michael J Robertson

Faculty, Staff and Students Publications

At sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding structure and function as well as guiding downstream design tasks, including structure-based drug discovery and de novo biomolecule design. However, direct identification of these sites from experimental data can prove challenging, and existing empirical approaches leveraging the local environment can only characterize limited ion types. We present a representation of chemical environments using interaction fingerprints and develop a machine learning model to predict the identity of …

Experiences Of Managing And Living With Autoimmune Addison’S Disease In The Younger And Newly Diagnosed Adults: An Interpretative Phenomenological Analysis, Mathew Horodner

Walden Dissertations and Doctoral Studies

There is a lack of knowledge regarding the experiences of managing and living with autoimmune Addison’s disease (AD) in the younger and newly diagnosed adults. AD research usually focuses on biological or medication studies. Thus, the purpose of this qualitative study was to understand the lived experiences of the younger and newly diagnosed adults living with autoimmune AD. Consisting of the complex integration of biological, psychological, and social factors, Engel’s biopsychosocial model served as the study’s conceptual framework. I conducted this study to include the experiences of managing and living with autoimmune AD in the younger (18–35) and newly diagnosed …

Big Five Personality Traits As Predictors Of Funeral Directors’ Job Satisfaction, Teresa Busick

Walden Dissertations and Doctoral Studies

By 2037, annual deaths in the United States are expected to exceed 3.6 million, over 1 million more than in 2015. At the same time, the funeral service industry faces a serious staffing problem, with about 50% of funeral directors leaving the profession within 2 years. These combined challenges highlight the need to understand what contributes to job satisfaction and helps to retain these workers in this essential field. This quantitative correlational study examined whether the Big Five personality traits predict job satisfaction among funeral directors. Thus, the Big Five model of personality traits was used to guide the study. …

Cortical Functional Organization In Early Childhood, Jiaxin Tu

Arts & Sciences Graduate Student Theses and Dissertations

The advent of connectivity-based methods, particularly those utilizing spontaneous BOLD signals, has significantly advanced brain mapping and deepened our understanding of the human brain's functional architecture. While prior research has explored functional organization in early childhood, most studies have focused on coarse, group-level distinctions aligned with adult literature, often within narrow age ranges. This dissertation extends these investigations by examining cortical functional organization in greater detail among healthy infants and toddlers aged 1 to 5 years. Chapter 1 employs spontaneous BOLD signals in sleeping infants and toddlers to derive a group-level functional organization at the resolution of areas and networks. …

Human Extravillous Trophoblasts Require Src-2 For Sustained Viability, Migration, And Invasion, Vineet K Maurya, Pooja Popli, Bryan C Nikolai, David M Lonard, Ramakrishna Kommagani, Bert W O'Malley, John P Lydon

Faculty, Staff and Students Publications

Defective placentation is a recognized etiology for several gestational complications that include early pregnancy loss, preeclampsia, and intrauterine growth restriction. Sustained viability, migration, and invasion are essential cellular properties for embryonic extravillous trophoblasts to execute their roles in placental development and function, while derailment of these cellular processes is linked to placental disorders. Although the cellular functions of extravillous trophoblasts are well recognized, our understanding of the pivotal molecular determinants of these functions is incomplete. Using the HTR-8/SVneo immortalized human extravillous trophoblast cell line, we report that steroid receptor coactivator-2 (SRC-2), a coregulator of transcription factor-mediated gene expression, is essential …

Pan-Cancer Immune And Stromal Deconvolution Predicts Clinical Outcomes And Mutation Profiles, Bhavneet Bhinder, Verena Friedl, Sunantha Sethuraman, Davide Risso, Kami E Chiotti, R Jay Mashl, Kyle P Ellrott, Jordan A Lee, Christopher K Wong, Kofi Gyan, Aditya Deshpande, Marcin Imielinski, Rohan Bareja, Josh Stuart, Myron Peto, Katherine A Hoadley, Alexander J Lazar, Andrew D Cherniack, Jingchun Zhu, Shaolong Cao, Mark Rubin, Wenyi Wang, Oliver F Bathe, Nicolas Robine, Li Ding, Peter W Laird, Wanding Zhou, Hui Shen, Vésteinn Thorsson, Jen Jen Yeh, Matthew H Bailey, Daniel Cui Zhou, Xianlu L Peng, Mary Goldman, Yongsheng Li, Anil Korkut, Nidhi Sahni, D Neil Hayes, Michael K A Mensah, Ina Felau, Anab Kemal, Samantha Caesar-Johnson, John A Demchok, Liming Yang, Martin L Ferguson, Roy Tarnuzzer, Zhining Wang, Jean C Zenklusen, Paul Spellman, Olivier Elemento

Faculty, Staff and Student Publications

Traditional gene expression deconvolution methods assess a limited number of cell types, therefore do not capture the full complexity of the tumor microenvironment (TME). Here, we integrate nine deconvolution tools to assess 79 TME cell types in 10,592 tumors across 33 different cancer types, creating the most comprehensive analysis of the TME. In total, we found 41 patterns of immune infiltration and stroma profiles, identifying heterogeneous yet unique TME portraits for each cancer and several new findings. Our findings indicate that leukocytes play a major role in distinguishing various tumor types, and that a shared immune-rich TME cluster predicts better …

Vigorous Physical Activity As A Potential Environmental Risk Factor In Renal Medullary Carcinoma, Daniel D Shapiro, Sagar S Mukhida, Andrew W Hahn, Ayman Isahaku, Schyler M Turner, Jessica P Cheng, Pankaj K Chauhan, Susan S Thomas, Beei Chan, Zita D Lim, Nizar M Tannir, Maria Chang Swartz, Pavlos Msaouel

Faculty, Staff and Student Publications

Purpose: Renal medullary carcinoma (RMC) is a rare but aggressive kidney cancer affecting young individuals with sickle hemoglobinopathies. Prior retrospective case-control and mouse modeling studies suggest a mechanism linking vigorous intensity physical activity to increased RMC risk in individuals with sickle hemoglobinopathies. This study aimed to prospectively investigate the association between vigorous intensity exercise and RMC.

Materials and methods: This study used a validated questionnaire to prospectively assess reported physical activity in a large cohort of patients with RMC compared to the activity of individuals without RMC. Between 2022 and 2024, patients with RMC (N = 39) were prospectively surveyed …

Supporting Patients With Advanced Cancer And Their Spouses In Parenting Minor Children: Results Of A Randomized Controlled Trial, Kathrin Milbury, Sujin Ann-Yi, Meagan S Whisenant, Morgan Jones, Yisheng Li, Victoria Necroto, Sania D Yousuf, Mariana Chavez-Macgregor, Larrisa Meyers, Eduardo Bruera

Faculty, Staff and Student Publications

Introduction: Patients with advanced cancer and their spousal caregivers who parent minor children report unmet parenting concerns and increased psychological distress. Seeking to address these important supportive care needs, this RCT examined the feasibility, acceptability, and initial evidence for the efficacy of a novel psychosocial intervention.

Patients and methods: Patients with a metastatic solid malignancy and their spouses completed self-reported validated assessments of psychological symptoms and cancer-related parenting outcomes and were then randomized to the parent support intervention or a usual care (UC) group. Both groups were reassessed 6 and 12 weeks later. Dyads randomized to the counselor-led intervention attended …

Vitamin D Receptor (Vdr) And Autoimmune Diseases, Zahraa M. Al-Taee, Noor Mahommoud Naji, Zeena Hadi Obaid Alwan, Anmar M. K. Al-Maamori, Rasha Kadhim Mahdi

Hilla University College Journal For Medical Science

The vitamin_D_receptor (VDR) has great role in the regulates of expression of gene in several organs, responsive to vitamin D, after activation by physiologically active vit.D. There is strong evidence that vit.D is work in several physiological pathways, since vit.D-activating receptors and enzymes have been found in cell types that are unrelated to mineral and bone homeostasis. Many processes are affected by the so-called non-classic effects of VDR activation. These involve cell death, growth and reproduction of cells, and immune cell activity among many others. Moreover, immunity cells such as activated “CD4+ and CD8+ T cells, B cells, neutrophils, and …

Seasonal Sea Ice Characterized The Glacial Arctic-Atlantic Gateway Over The Past 750 000 Years, Monica Winsborrow, Pengyang Song, Simon Belt, Jochen Knies, Henning A. Bauch, Lukas Smik, Gerrit Lohmann

School of Geography, Earth and Environmental Sciences

The past occurrence of an extreme ~1-kilometer–thick Arctic Ocean–Nordic Seas ice shelf has been inferred from submarine landscape features and geochemical records, although fundamental aspects of its characteristics, impacts, and timing remain highly debated. Here, we challenge this pan-Arctic glaciation hypothesis by investigating two sites from the Arctic-Atlantic gateway (AAG) and the Nordic Seas. Suborbital to millennial-scale surface water bioproductivity changes provide no evidence for a continuous ice shelf in the AAG and the Nordic Seas over the past ~750,000 years. Instead, proxy data and model simulations reveal the persistent presence of seasonal sea ice cover and open water phytoplankton …

The Human Catalyst And Extractivist Fiction: A Close Reading Of Siddhartha Sarma’S Year Of The Weeds And Pundalik N Naik’S The Upheaval, Elwin Susan John Dr

Critical Humanities

Literary narratives have been abetting the various global faces of climate crisis, ever since the disciplines of humanities and social sciences have become vocal about the Anthropocene. The discussions have been mostly centered around the discourses of capitalism, imperialism, rights and subalterity. By reading some of these foundational grips on ecological crisis, the present essay analyses literary narratives on mining and extraction in India from the standpoint of a human catalyst; which is defined as an entity that can cause a chain reaction, that may or may not result in the annihilation of the initial catalyst. The essay will begin …

Towards An Indigenous Climate Epistemology: Bringing The Newa Literary Tradition Of The Swasthani Vrata Katha In Conversation With The Festival Tradition Of The Macchindra Nath Jatra, Shangrila Joshi Dr.

Critical Humanities

This paper brings into conversation two Newa cultural traditions to articulate notions of climate adaptation, resilience, and mitigation, to illustrate how ways of knowing, ways of being, and ways of governing are inherently linked. These articulations offer a framework for developing what the author calls an Indigenous Climate Epistemology. The two cultural traditions reviewed include: a 17^th century Newa literary tradition that advocates for keeping oil in the ground, and that instructs ordinary people to engage in ritual acts seemingly designed to develop personal and community resilience; and a 1700 year old annual community festival designed to avert catastrophes …

The Radical Potential Of Ecopoetics: Ecological Intimacy In Forrest Gander’S Twice Alive, Thomas Storey

Critical Humanities

Ecopoetics is a contested term, one defined by its capaciousness. Through its focus on deep ecology, it draws together the world system and the individual, the collective and the singular, and the global and the placed-based within its dialectical framework, without resolving any of these oppositions. Instead, the apparent contradictions underlying ecopoetics offer productive material for a poetic praxis that aims to foreground the complex connections that string together nature, culture, politics, and society. Forrest Gander’s Twice Alive engages with these contradictions in an attempt to foreground the intimacy of ecological thinking, and its basis in personal connections that are …

The Astrobiological Figure Of Humboldt As Pioneer In The Rock Varnish Research, Jose Jordan-Soria

Homage to Alexander von Humboldt: Travels to and from Spain Throughout the Centuries / Homenaje a Alexander von Humboldt: Viajes hacia y desde España de todos los siglos

From Humboldt is particularly interesting -and little know- his description of mineral coatings on rocks 200 years ago, reported in his book Personal Narrative of Travels to the Equinoctial Regions of the New Continent during the years 1799-1804, co-written with Aimé Bonpland, for which is considerate the father of rock coating research. On June 5th 1799 set sail from A Coruña -Spain- to Cumaná -Venezuela- beginning five years of expedition. While they explored the Orinoco River system, in th eriver basin waterfalls, Humboldt observed the presence of dark coating depositions. He ascertained a manganese-rich accretion, reporting similar structures in other …

Harnessing Environmentally Healthy Approaches For Plastic Degradation: A Review And Future Perspectives, Marc Chojnacki

Beyond: Undergraduate Research Journal

In the face of escalating plastic pollution, innovative degradation strategies, such as enzymatic degradation, smokeless incineration technology, and biodegradable plastics, are gaining traction. This paper collates comprehensive research on these methods, assessing their environmental impact and operational feasibility. A special focus is placed on the role of technology and its capacity to spark advancements in these degradation strategies as well as to draw on specific research to understand the economic implications of these methods. At the core of this study is the exploration of potential new, inventive degradation methodologies. Through examining methods of green plastic degradation, the study aims to …

Comparison Of Autograft, Allograft, And Conduits For Peripheral Upper Extremity Nerve Repair A Critical Review Of The Current State Of Bone Grafting In Orthopaedic Surgery, Samantha Meacock

Bone Bulletin

Introduction

Several mechanisms of injury can cause peripheral nerve injury (PNI) and subsequent impaired quality of life with loss of motor and/or sensory function. Trauma is a common cause of injury with the most commonly injured nerves being the radial (53%), ulnar (32%), and median nerves (15%).¹ The preferred treatment for PNI is reconnecting severed nerve ends anatomically with tension-free end-to-end direct nerve repair of healthy fascicles. However, if the nerve ends cannot be brought together without tension, gapping can occur, and a direct tension-less repair is not possible.⁵ In the case of a lengthy nerve gap, a …

Implementing A Sustainability Approach By Converting Plastic Bottle Waste From A Mischievous Substance To A Beneficial Material By Means Of Zero Residue Level Concept, Younus Mohammed Abed, Fatima Allawi, Shahad Mudhafar Ali, Salem Jawad Alhamd, Thekra Atta Ibrahim, Mohammed Nsaif Abbas

Karbala International Journal of Modern Science

Plastic waste represents a serious environmental and health hazard due to its non-biodegradability and toxic leachates. This study investigates the potential conversion of plastic waste into a sustainable raw material for producing a useful substance. This investigation focuses on repurposing PET beverage bottles—a major contributor to microplastic pollution—into high-value activated carbon (AC) for water treatment, aligning with circular economy principles. The chemical preparation method for AC using phosphoric acid as an activating agent was evaluated. Results demonstrated the successful conversion of 68% of plastic waste into AC under the following conditions: pyrolysis temperature of 700°C, pyrolysis time of 7 hours, …

Late Onset Malignant Metastatic Transformation Of Benign Pheochromocytoma, Maha Zafar, Reshly Mary Rajan, Manaswini Krishnakumar, Aswanth Reddy

Journal of Community Hospital Internal Medicine Perspectives

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors arising from adrenal medulla and extra-adrenal paraganglia. Metastatic pheochromocytomas, pose diagnostic and therapeutic challenges due to their atypical presentations and potential for malignant transformation years after primary tumor resection. We report a case of 61-year-old woman who presented with intermittent cough, shortness of breath, and elevated blood pressure 6 years after resection of primary adrenal pheochromocytoma. Imaging revealed bilateral pulmonary nodules, a retroperitoneal mass, and L4 vertebral involvement, raising suspicion for metastatic pheochromocytoma. Elevated serum metanephrines and normetanephrines, alongside tissue biopsy and MIBG imaging, confirmed diagnosis. Germline genetic testing did not reveal …

An Unusual Presentation Of Iga Vasculitis And Iga Nephropathy: A Case Report, Mark A. Colantonio, Nicholas Condiles, Alan P. Lim, Khaled Shawwa

Journal of Community Hospital Internal Medicine Perspectives

Immunoglobulin A (IgA) nephropathy is the most common glomerulonephritis worldwide. While IgA nephropathy mainly presents with renal manifestations, systemic symptoms associated with vasculitis are uncommon. Oftentimes, creatinine is used as a serum marker for renal dysfunction; however, it may not always be sensitive, especially in patients with low muscle mass. In such cases, cystatin C may prove to be a better indicator of renal function. Here, we present a case of IgA nephropathy with a normal serum creatinine and elevated cystatin C, highlighting the utility of cystatin C in the setting of a normal creatinine and high suspicion for renal …

Pulmonary Mycobactetrium Kumamotonense With Hepatosplenic Dissemination In An Immunocompetent Patient: A Case Report And Review, Michael S. Wang, Jeremiah Chang, Tiffany Whelan, Bo Liu, Katie Fitton, Jeffrey J Grondin

Journal of Community Hospital Internal Medicine Perspectives

We report a 69-year-old with a past medical history of prostate cancer and arsenic poisoning, who was incidentally found to have multiple pulmonary nodules and hepatosplenic lesions on CT imaging. He denied respiratory symptoms, but was noted to have significant weight loss. A bronchoscopy revealed mycobacterium kumamotonense on culture. He was treated presumptively for pulmonary and disseminated infection with azithromycin and ethambutol for 16 months, and 12 months of rifabutin after four months of rifampin which was discontinued due to resistance. Patient’s weight loss resolved and CT imaging appeared significantly improved.

Introduction To Sociology: Interaction And Social Structure, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the intricate interplay between micro- and macro-sociological perspectives on social interaction, identity, and structure. Through an examination of theoretical approaches such as symbolic interactionism, dramaturgy, and social exchange, it highlights how individuals construct and perform identities within complex webs of social expectations—particularly shaped by factors like race, status, and role dynamics. The discussion extends to the function of social networks in influencing opportunities, notably in the context of employment, underscoring the nuanced role of weak ties. The analysis further delves into the significance of social status, distinguishing between ascribed, achieved, master, and salient statuses, and examines …

Effects Of Self-Monitoring On Teachers’ Behavior-Specific Praise And Students’ Behavior In A Center-Based Classroom, Samantha Walsh

Theses

The current study explores the effects of self-monitoring on teachers' use of behavior-specific praise (BSP) and its impact on student behavior in a center-based classroom. Self-monitoring, a cost-effective and time-efficient intervention, has been proven effective in previous research for enhancing educator performance. However, previous studies have often combined self-monitoring with other interventions, leaving a gap in understanding its effects in isolation. This study aims to replicate the work of Justus et al. (2023) by examining the impact of self-monitoring on paraprofessionals in a center-based classroom with students aged 6-10. Using a multiple baseline design across participants, three paraprofessionals were trained …

Pacific Rxtracts - July 2025, Pacific Rxtracts

Pacific RxTracts

Articles:

• First Blood Test Approved For the Diagnosis of Alzheimer’s Disease
• Rare Withdrawal Reaction Prompts Label Update for Common Antihistamines
• FDA Approves SUSVIMO: Shifting Diabetic Retinopathy Treatment from Monthly Injections to Continuous Therapy
• Battle Against Resistant Hypertension
• Two Is Better than One: Obicetrapib and Ezetimibe, a Novel Combination Pill for High Cholesterol
• Histo-blood Group ABO System Transferase and Venous Thromboembolism Risk
• GLP-1 Agonists and Thiazolidinedione Combination Therapy in Type 2 Diabetes
• Dual Pathway Targeting in Type 2 Diabetes: Exploring the Synergy of GLP1- RAs and SGLT2-inhibitors
• Two Vaccines, One Shot: Combined Immunizations Against COVID-19 and Influenza
• Mirikizumab: A New Frontier …

Introduction To Sociology: The Family, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the evolving landscape of modern family structures, analyzing their diverse forms, core functions, and the challenges they face within contemporary society. Drawing on recent research and theoretical frameworks, it examines the transformation of parenthood—especially single fatherhood—the shifting definitions of family and kinship, and the influence of family structure on emotional security, socialization, and reproductive roles. The discussion highlights the rise of dual-career households, increased grandparental involvement, the complexities of blended and single-parent families, as well as the growing acceptance of cohabitation and child-free couples. Special attention is given to persistent social problems, such as the cycles …

Introduction To Sociology: Sex And Gender, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the complex interplay between sex and gender, focusing on how societal structures, historical contexts, and cultural norms shape gender roles and expectations. Drawing on the works of influential theorists such as Margaret Mead and researchers like Maccoby and Jacklin, the discussion distinguishes between biological sex differences and socially constructed gender distinctions. The analysis highlights the pervasive influence of gender socialization through agents such as family, peers, educational institutions, and media, which collectively reinforce stereotypes and stratify opportunities for individuals. The evolution of gender stratification is traced from the post-World War II era to the present, documenting …

Introduction To Sociology: Class And Stratification, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper explores the intricate dynamics of class, stratification, and social inequality, emphasizing the interplay of wealth, power, and prestige in shaping individual opportunities and societal outcomes. Drawing on foundational theories from Marxist and functionalist perspectives, it examines the mechanisms by which economic and social structures reinforce or challenge class divisions. The analysis extends to the evolution of American economic disparity, particularly during the transformative 1980s, and examines policies aimed at addressing poverty, such as those articulated by Sar Levitan and the implementation of the Social Security Act. Through a nuanced discussion of cultural capital, the role of …

Organizational Culture And Work Environment As Determinats Of Teacher Motivation: A Quantitative Study In Slb, Pekalongan Regency, Nur Kholifah, Widya Kusumaningsih, Nurkolis Nurkolis

Journal of ICSAR

This study examines the influence of organizational culture and work environment on the work motivation of Special Needs School (SLB) teachers in Pekalongan Regency. Using a quantitative descriptive-correlational approach, data were collected from 103 SLB teachers through a Likert-scale questionnaire. The results show that both organizational culture and work environment have significant and positive effects on teacher motivation, both partially and simultaneously. Organizational culture contributes 46% and work environment 56% to the variation in work motivation, while together they account for 58%. The highest contributions come from intrinsic motivation and the non-physical work environment. These findings emphasize the importance of …

Robust Embeddings Of Genetics, Anatomy, And State Decoded From A Neuron’S Activity, Aidan Schneider

Arts & Sciences Graduate Student Theses and Dissertations

Neural spike trains are shaped by both extrinsic inputs and intrinsic structural constraints. While prior work has focused on how spike timing encodes externally driven variables, such as stimuli or behavior, this dissertation explores whether principles that organize neural activity in space and time—such as genetic cell type, anatomical location, and arousal state—are also embedded in the spiking output of individual neurons. I hypothesize that these organizing principles are not quenched as irrelevant variability, but rather multiplexed within the neural code itself. To test this, I attempt to decode these principles from the spike trains of neurons recorded in behaving …

Quantum Magnetization Exchange Through Transient Hydrogen Bond Matrix Defines Magnetic Resonance Signal Relaxation And Anisotropy In Central Nervous System, Dmitriy A Yablonskiy, Alexander L Sukstanskii

2020-Current year OA Pubs

The integrity of cellular membranes (lipid bilayers) and myelin sheaths covering axons is a crucial feature controlling normal brain structural and functional networks. Yet, in vivo evaluation of this integrity at the nanoscale level of the cellular membranes organization is challenging. Herein we explore the dual property of biological water in Central Nervous System (CNS), as one of the major stabilizing factors of cellular membranes, and the major source of MRI signal. We introduce the Basic Transient Hydrogen Bond (THB) model of the MR signal relaxation due to the quantum spin/magnetization exchanges within the THB Matrix encompassing water molecules and …

Extrusion Process Optimization Of Sea Red Rice And Its Physicochemical Properties , Digestion Characteristics , And Nutritional Components, Sun Wufei, Wang Zhuo, Zhong Saiyi, Zou Wentao, Hu Jiakang

Food and Machinery

［Objective］ To investigate the effects of extrusion technology on the physicochemical properties,digestion characteristics,and nutritional components of sea red rice.［Methods］ The extrusion process parameters for sea red rice are optimized by response surface methodology.The effects of the extrusion treatment on the physicochemical properties of the sea red rice flour are explored by water solubility index (WSI ),gelatinization degree,starch digestion properties (including rapidly digestible starch,slowly digestible starch,and resistant starch ),and the anti -nutritional factor content (phytic acid ).The microstructure,starch crystal form,and crystallinity are 钟赛意（1979—），男，广东海洋大学教授，博士。E-mail：zsylxc@ 126.com引用格式：孙武飞，汪卓，钟赛意，等.海红米挤压工艺优化及理化性质、消化与营养特性研究 ［J］.食品与机械，2025，41（6）：164-172.C itation:SUN Wufei,WANG Zhuo,ZHONG Saiyi,et al.Extrusion process optimization of sea red rice and its physicochemical properties,digestion characteristics,and …