Digital Commons Network^™

“Here’S To The Long Haul: Dark Green Religion And Planetary Thinking In Appalachian Environmental Movements”, Joseph Witt

Critical Humanities

Environmental humanities scholars have worked to develop alternative frameworks for understanding and relating to Earth’s systems in the hope of reforming the exploitative and extractive practices and attitudes characteristic of the Anthropocene. For example, Dipesh Chakrabarty argued that addressing climate change necessitated appreciating the entanglements between global (human) and planetary (Earth systems) scales. While Chakrabarty noted that ancient and Indigenous cultures may have retained approaches necessary for this work, he was skeptical of the ability of modern secular intellectual traditions focused on global justice perspectives to ultimately facilitate a planetary non-anthropocentric ethic. However, by only briefly engaging with themes of …

A Novel Approach To Increase Accuracy In Remotely Sensed Evapotranspiration Through Basin Water Balance And Flux Tower Constraints, Kul Khand, Gabriel B. Senay, Mackenzie Friedrichs, Koong Yi, Joshua B. Fisher, Lixin Wang, Kosana Suvočarev, Arman Ahmadi, Housen Chu, Stephen Good, Kanishka Mallick, Justine Missik, Jacob A. Nelson, David E. Reed, Tianxin Wang, Xiangming Xiao

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Remote sensing-derived evapotranspiration (RSET) products capture the spatiotemporal variations of evapotranspiration (ET) from field to basin scales with unprecedented details. However, their accuracy varies across RSET estimation methods and diverse hydroclimate regions. While ET modeling efforts to account for biophysical processes and controlling parameters have made good progress in recent years, a parallel approach of integrating in-situ ET with RSET could reduce biases in RSET products. Basin water balance ET (WBET) and flux tower ET are widely applied to evaluate RSET accuracy, yet such ET measurements are rarely used for RSET bias corrections, especially for large area applications. To address …

Exploring Sex-Specific Clinical Features In Chinese Patients With Takotsubo Syndrome, Hong-Yi Duan, Ling-Lin Wang, Ling-Chun Lyu, Zhen-Hua Shi, Xiao-Ping Lin, Zheng-Yang Yu, Guo-Hua Fan, Jing Chen, Xin-Hong Yang, Wei Deng, Chang-Wu Xu, Yan Huang, Qing Zhou, Jin-Ling Chen, Hong-Ning Song, Dong Hu, Jin-Qiu Liu, Hector Barajas-Martinez, Charles Antzelevitch, Kan Liu, Hong Jiang, Dan Hu

Department of Medicine Faculty Papers

BACKGROUND: Takotsubo syndrome (TTS) is considered as a transient acute heart failure syndrome predominant in females. However, data on Chinese TTS patients are limited. Therefore, this study aimed to investigate the clinical characteristics of Chinese TTS patients, identify prognostic markers.

METHODS: A total of 258 TTS patients were enrolled. Data on clinical characteristics and in-hospital major adverse cardiovascular events (MACE) were collected and analyzed. The latter included severe heart failure, shock, malignant arrhythmia, and death.

RESULTS: The average age of TTS patients was 59.3 ± 19.2 years. Female patients accounted for 68.9%. MACE occurred in 41.4% of patients during hospitalization. …

Pan-Cancer, Multi-Omic Correlates Of Survival Transcending Tumor Lineage Across 11,019 Patients Reveal Targets And Pathways, Yiqun Zhang, Fengju Chen, Chad J Creighton

Faculty, Staff and Students Publications

Molecular correlates of cancer patient overall survival (OS) can provide new insights. Here, we systematically cataloged pan-cancer, multi-omic correlates of OS transcending tumor lineage across 11,019 patients, involving multiple cancer types while correcting for cancer-type-intrinsic OS differences. Significant fractions of genes with mRNA associated with OS in pan-cancer analyses showed concordant associations at the levels of DNA copy number alteration or methylation. Pan-cancer gene signatures of T-cell and macrophage tumor infiltrates were associated with better and worse OS, respectively. Pathways implicated by molecular OS associations included metabolism, PI3K/Akt, Wnt, and TGF-beta receptor. Significant fractions of worse OS-associated genes were essential …

Latine Students’ Stem Identity Development: Reflecting On Implicit Biases, Imposter Syndrome, Self-Efficacy, And Support Systems, Alyssa G. Cavazos, Valerie Leija, Javier Cavazos Vela

Writing and Language Studies Faculty Publications

This study used an equity ethic framework and a STEM identity model to contextualize and understand Latine students’ perceptions of STEM identity development. The purpose of this study was to investigate how Latine undergraduate students who engaged in STEM coursework perceived their learning experiences and stories of resilience through an equity ethic framework. Data were collected through interviews with 19 Latine college students attending a Hispanic-Serving Institution. Findings revealed the following themes related to Latine students’ STEM identity development and lived experiences in STEM coursework: implicit biases, imposter syndrome, self-efficacy, and support system and resources. Findings highlight the need for …

Preliminary Investigation Of The Association Between Epigenetic Aging Acceleration And Amyloid Biomarkers In Bipolar Disorder, Gabriel R Fries, Steven De La Garza, Ning O Zhao, Andres W Bass, Camila N C Lima, Nobuhide Kobori, Tatiana Barichello, Gustavo Turecki, Paul E Schulz, Breno S Diniz, Jair C Soares

Faculty, Staff and Student Publications

Objectives: Bipolar disorder (BD) has been associated with an elevated risk of Alzheimer's Disease (AD). We assessed AD biomarkers in BD and tested whether epigenetic aging (EA) acceleration is associated with changes in these markers.

Design, setting, participants: Cross-sectional study of n = 58 living individuals with BD and n = 20 age- and sex-matched control participants, as well as analyses of postmortem brain samples (Brodmann area 9/46) from n = 46 individuals with BD.

Measurements: Amyloid beta (Aβ)40, Aβ42, and total Tau levels were measured in plasma from individuals with BD and controls, and Aβ42 levels were measured in …

Emergent Collective Reproduction Via Evolving Neuronal Flocks, Nam H. Le, Michael Levin, Richard A. Watson, Josh Bongard, Christopher L. Buckley

Northeast Journal of Complex Systems (NEJCS)

This study advances the understanding of evolutionary transitions in individuality (ETIs) through a novel artificial life framework, VitaNova, which integrates self-organization and natural selection to simulate the emergence of complex, reproductive groups. By dynamically modeling individual agents within an environment shaped by predators and spatial constraints, VitaNova reveals mechanisms by which simple agents evolve into cohesive units exhibiting collective reproduction. The findings highlight the synergy between self-organized behaviors and adaptive evolutionary strategies as fundamental drivers of ETIs. This approach deepens our understanding of higher-order biological individuality and offers a new empirical pathway for investigating ETIs, extending current theoretical frameworks.

Exact Solutions Of M-Fractional Complex Ginzburg-Landau Equation Via Two Analytical Methods, Nematollah Kadkhoda, Mojtaba Baymani, Maad M. Mijwil, Mostafa Abotaleb

Iraqi Journal for Computer Science and Mathematics

This article investigates the M-fractional complex Ginzburg-Landau (CGL) equationby utilizing the modified simplest equation method and the modified G'G-expansion method. The CGL holds significant importance in the realm of oscillatory phenomena and optical fibers. By implementing a fractional complex transformation, the M-fractional CGL equation is transformed into an ordinary differential equation (ODE).By employing these methodologies, bright periodic solutions, periodic solutions, and dark wave solutions relevant to phenomena witnessed in nonlinear optics or plasma environments are ascertained.It is demonstrated that these methods are very powerful and efficient to solve many fractional differential equations.

Reason for Expression of Concern: …

Challenges And Constraints In Trajectory Planning For Autonomous Robots, Jawad Abdouni, Tarik Jarou, Toufik Mzili, Abderrahim Waga, Karima Bensassi

Iraqi Journal for Computer Science and Mathematics

Autonomous mobile robots have revolutionized navigation by operating without human intervention, leveraging advanced data acquisition systems such as cameras, radar, and LIDAR, along with sophisticated planning, localization, and control algorithms. A critical challenge in this domain is path planning: determining optimal trajectories to ensure safe and efficient travel in diverse environments. This paper addresses the need to systematically evaluate trajectory-planning algorithms, whose selection directly impacts navigation performance. We present a comprehensive analysis of various classes of path-planning methods, detailing their advantages, limitations, and application contexts. By comparing these algorithms, we identify key criteria for selecting the most suitable approach for …

Efficacy And Rationale Of Differentiated Racecadotril Doses Combined With Bifidobacterium Triple Viable In Managing Pediatric Persistent Diarrhea: A Comprehensive Analysis, Yanrong Liu, Li Ma, Dian Jin, Jingli Peng, Han Wei, Xueyun Zhang, Yajing Wu

Journal of Pediatric Infectious Diseases

Objective: Pediatric persistent diarrhea poses a severe burden on children's health. This study investigates the efficacy and fundamental mechanisms of varying doses of racecadotril in combination with bifidobacterium triple viable for treating this condition in children. Methods: Employing a randomized controlled trial design, participants diagnosed with pediatric persistent diarrhea were randomly allocated to a high-dose group (observation) and a low-dose group (control), both treated with racecadotril combined with bifidobacterium triple viable. During treatment, clinical parameters were meticulously recorded and analyzed. ELISA techniques were utilized to quantify alterations in immune, inflammatory, and oxidative stress markers in serum. Quantitative culture methods for …

Lncrna Mzf1 Antisense Rna 1 Promotes Mycoplasma Pneumoniae Pneumonia In Children Via Mir-16-5p, Qin Wang, Bing Han, Yanan Ji, Cuicui Zhang, Lianying Ruan, Hengrui Hao

Journal of Pediatric Infectious Diseases

Objective: To determine the expression, as well as the underlying mechanism, of lncRNA MZF1 antisense RNA 1 (MZF1-AS1) in Mycoplasma pneumoniae pneumonia (MPP). Methods: GSE179051 was analyzed for differentially expressed lncRNAs in MP infection. The levels of MZF1-AS1 were determined by quantitative Real-time PCR in children with MPP and healthy subjects. The diagnostic value of MZF1-AS1 was assessed using ROC curves. The effects of MZF1-AS1 knockdown on A549, human primary alveolar macrophages (hpAM) and human airway smooth muscle (ASM) cell function were assessed. The downstream miRNA for MZF1-AS1 was predicted and validated. Results: MZF1-AS1 was a differentially expressed lncRNA in …

The Impacts Of Fluconazole On Invasive Fungal Infection, Colonization, And Overall Mortality In Preterm Infants: An Updated Systematic Review And Meta-Analysis, Tiehui Huang, Xue Zhang, Xueqiao Lei

Journal of Pediatric Infectious Diseases

Objective: Invasive fungal infection is not uncommon in preterm infants, and fluconazole has been reported to prevent fungal infection. The impacts of fluconazole on invasive fungal infection in preterm infants can be evaluated using an updated systemic review and meta-analysis of randomized clinical trials. Methods: The log risk ratio was transformed using the risk ratio and 95% confidence interval to assess the impacts of fluconazole on fungal infection in preterm infants. After selection, eleven randomized clinical trials of 1097 preterm infants with fluconazole prophylaxis and 953 preterm infants in the control group were enrolled. The focused outcome was the risk …

Soft-Polymeric Contact Lenses Brands Evaluation According To User Preferences, Lina M. Shaker, Wan Nor Roslam Wan Isahak

AUIQ Technical Engineering Science

The development of soft-polymeric contact lenses (SPCLs) has significantly enhanced vision correction by integrating advanced polymeric materials with optimized optical properties. This study examines the impact of refractive index (RI), oxygen permeability (Dk/t), and water content (EWC%) on visual quality and ocular health, correlating material properties with user-reported experiences. A survey of 5,585 medical SPCL users revealed that 31% experienced ocular fatigue and redness, often linked to optical aberrations and replacement frequency. Notably, commercially available SPCLs exhibit RI values ranging from 1.37 to 1.43, deviating from the natural ocular tissue RI (∼1.33), which contributes to light distortions and reduced visual …

Internet Of Things In Sustainable Agriculture Systems, Ataguba E. Hillary, Ayodeji A. Okubanjo, Nurudeen. S. Lawal, Abisola A. Olayiwola

AUIQ Technical Engineering Science

The agriculture industry has evolved toward intelligent, data-driven processes due to the growing need for food worldwide, environmental sustainability, and effective resource use. A thorough analysis of smart agriculture as a game-changing element of the industry 4.0 revolution is provided in this study, with a focus on the incorporation of Internet of Things (IoT)-based technologies for sustainable farming. To optimize agricultural processes including irrigation, crop health monitoring, climate and weather tracking, animal management, and disease detection, it investigates the functions and uses of smart sensors and IoT devices. The study demonstrates how smart agriculture may meet important issues like food …

Effects Of 25-Hydroxyvitamin D₃ Supplementation As A Partial Replacement For Vitamin D₃ On Laying Performance, Egg Quality, And Bone Traits In Late-Stage Laying Hens, Morakot Nuntapaitoon, Nan Choisunirachon, Somporn Techangvamsuwan, Jiramate Jittidecha

The Thai Journal of Veterinary Medicine

The objective of this study was to assess the impact of dietary 25-hydroxy vitamin D₃ (25OHD₃) supplementation during the late laying hens on egg quality, hen performance and bone computerized tomography (CT) scanning parameters. In total, 24,862 Hy-Line Brownmax hens of 61 weeks old were randomly divided into two groups: the control group (n = 12,368) received a diet containing vitamin D₃ at 3,000 IU/kg, and the treatment group (n = 12,494) received a diet containing vitamin D3 at 1,500 IU/kg and 25OHD₃ at 1,500 IU/kg. The dietary intervention from 61 weeks of age to …

Pollution And Biodiversity Loss: A Comprehensive Review Of Impacts And Mechanisms, Great Iruoghene Edo, Agatha Ngukuran Jikah, Patrick Othuke Akpoghelie, Joseph Oghenewogaga Owheruo, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Arthur Efeoghene Athan Essaghah

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Biodiversity plays a vital role in maintaining ecological balance and providing essential ecosystem services. However, human activities, including pollution and overexploitation, have led to significant biodiversity loss. Pollution has particularly emerged as a major threat to biodiversity, impacting various species and ecosystems worldwide. This article synthesizes evidence on pollution-driven biodiversity loss, emphasizing industrial, agricultural, and urban sources. We discuss cascading ecosystem impacts and propose mitigation strategies to inform policy making. Overall, the article highlights the importance of addressing the impact of pollution on biodiversity to ensure the preservation of our planet's ecology and the sustainability of our natural resources.

Biosynthesis Of Metallic Nanoparticles Using Plant Extracts: Mechanisms, Advances, And Sustainable Applications, Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie, Endurance Fegor Isoje, Ufuoma Augustina Igbuku, Joseph Oghenewogaga Owheruo, Arthur Efeoghene Athan Essaghah

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Growing concerns over the environmental and health impacts of conventional nanoparticle synthesis have driven a shift toward green, plant-based methods. This review highlights the biosynthesis of nanoparticles using plant extracts as a sustainable, economical and non-toxic alternative. Plant-derived phytochemicals such as flavonoids, phenolics, and alkaloids serve dual roles as natural reducing and stabilizing agents, enabling the production of nanoparticles typically ranging between 10 and 100 nm. Several studies have demonstrated up to 80% yield improvement when using optimized extracts from plants like Azadirachta indica and Ocimum sanctum. The review outlines recent progress, including the use of novel botanical sources, …

Especial Linkage To Poly(Vinyl Chloride) Structure To Enhance Its Characteristics, Amamer M. Redwan

Al-Mustaqbal Journal of Sustainability in Engineering Sciences

Due to a variety of factors that motivated multiple creativities, modification of poly(vinyl chloride) chemical structure has become a flourishing area of research. The current study acts as a condensed overview of the improvements produced using various methods for adjusting the characteristics of poly(vinyl chloride) that is widely utilized. This study explains and emphasizes, through a brief discussion, the findings of the efforts made in recent decades, even if it does not address all of the issues at hand. The article covers a special linkage to the polymer chemical structure such as using heterocyclic moieties to modify poly(vinyl chloride), C–N …

Positive And Negative Parity States Of 226-236th Isotopes, Ali A. Mezban, Falih H. Al-Khudair

Karbala International Journal of Modern Science

The level scheme of the ^226-236Th nuclei is analyzed using the Interacting Boson Model (IBM-1). The ground state band (g. s.-band), beta band (β-band), gamma band (γ-band) have been described in the sd model space. To calculate the negative parity energy levels, the model space is extended to sdf by adding the f-boson (L=3). A sequence of states in energy bands up to 3.5 MeV has been obtained. The decay of negative states below 1 MeV built on an octupole vibration modes is investigated. The transition probabilities in-band and inter-band are calculated using the wave function of the …

Institutional Animal Care And Use Committees And The Challenges Of Evaluating Animal Research Proposals, John J. Pippin, Jarrod Bailey, Mark Kennedy, Debra Dubow Press, Janine Mccarthy, Ron Baron, Stephen Farghali, Elizabeth Baker, Neal D. Barnard

Non-Animal Methods and 3Rs

In the U.S. and many other countries, oversight committee approval is a common requirement for conducting research and publishing its findings. However, in evaluating whether research aims could have been achieved by methods other than the use of animals, these committees face a challenging task. In the U.S., there is no requirement that committee members have expertise in the research areas under review or in methods that could replace animal use, nor could expertise in such vast technical areas be expected. Consideration of alternatives to painful procedures is not required at all for experiments on animals not covered by the …

Development And Characterization Of Pmma/Pvp Nanofiber-Loaded Bioactive Agents With Enhanced Breast Cancer Activity, Samar A. Salim, The British University In Egypt, Esraa Abdelazim, Marwa Abdel Aleem

Nanotechnology Research Centre

Breast cancer remains a leading cause of cancer-related mortality globally, driving the need for novel effective and less toxic therapeutic agents. This study explores the synthesis and characterization of bioactive compounds: 1-(4-methoxyphenyl)-N- (p-tolyl)methanimine (MPTI), N-(4-methylphenyl)benzamide (MPB), and 4-methyl-N-(p-tolyl)benzenesulfonamide (MTS), and their incorporation into a PMMA/PVP polymer matrix for potential anticancer applications. Morphological analysis of the PMMA/PVP-loaded agents via SEM depicts structural modifications in the PMMA/PVP nanofibrous matrix upon incorporation of the bioactive agents. The FTIR analysis of the synthesized compounds before and after loading into the 7PMMA:3PVP nanofibers reveals successful incorporation of MPTI, MPB, and MTS, with characteristic absorption bands …

Chromatography In Analysis And Quality Control Of Oil And Gas Products: Modern Approaches And Prospects, Muborak Akramovna Mirshomilova, Natalia Evgenievna Sheina, Lala Bekirova

Technical science and innovation

Chromatography plays a key role in the analysis and quality control of oil and gas products. Modern chromatographic methods, including gas and liquid chromatography, provide high accuracy, sensitivity and speed of analysis. They allow you to identify impurities, control the composition and compliance of products with standards. The article considers innovative approaches, such as multidimensional chromatography and the use of automated systems. Development prospects are discussed, including integration with AI and digital technologies, which opens up new opportunities to improve the efficiency of quality control in the oil and gas industry. This article considers the role of chromatographic methods in …

Fish Assemblages And Flow Regimes Upstream And Downstream Of Falcon Reservoir, Christopher J. Austin, Christopher Taylor

School of Integrative Biological & Chemical Sciences Faculty Publications

The lower Rio Grande is regulated by Falcon and Amistad dams, as well as series of smaller dams and rock weirs. Several native fish species that rely on a natural flow regime for habitat and spawning are imperiled in the region. We analyzed streamflow discharge above and below Falcon Reservoir to assess potential impacts of dam impoundment on the fishes and flow regime. Fish collections were conducted by seine, and river discharge data was provided by the International Boundaries and Water Commission. We found significant differences in fish assemblages above vs below Falcon Reservoir, and the flow regime was significantly …

Mesenchymal Stem Cell-Derived Extracellular Vesicles: Seeking Into Cell-Free Therapies For Bone-Affected Lysosomal Storage Disorders, Andrés Felipe Leal, Harry Pachajoa, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Lysosomal storage disorders (LSDs) constitute a group of monogenic systemic diseases resulting from deficiencies in specific lysosomal enzymes that cause the intralysosomal accumulation of non- or partially degraded substrates, leading to lysosomal dysfunction. In some cases of LSDs, the bone is more severely affected, thus producing skeletal manifestations in patients. Current therapies, such as enzyme replacement therapy (ERT) and gene therapy (GT), show limited efficacy in correcting skeletal abnormalities. Increasing evidence suggests that microenvironmental disturbances also contribute significantly to disease pathogenesis. Therefore, therapeutic strategies targeting lysosomal dysfunction and microenvironmental dysregulation are needed. Mesenchymal stem-cell-derived extracellular vesicles (MSC-EVs) are emerging as …

Introduction To Sociology: Socialization, Dr. Marcia Morrison Ph.D.

Open Educational Resources

Abstract

This paper offers a comprehensive examination of socialization and identity development through a comparative lens, focusing on American, Chinese, and Japanese cultures. It explores how distinct cultural values—individualism, loyalty, and cooperation—shape personal and collective identities from childhood through old age. Utilizing the life course perspective, the analysis considers how factors such as generation, socioeconomic status, race, and gender influence the trajectory of human development. The evolution of childhood is traced across historical and cultural contexts, highlighting shifting perceptions, the impact of industrialization on children's roles, and the persistent influence of class and ethnicity on access to education and well-being. …

Chaperone-Usher Pathway Pili Adhesin Conformations And Inhibitors In Urinary Tract Infections, Edward Lopatto

Arts & Sciences Graduate Student Theses and Dissertations

Antibiotic resistant bacteria are becoming increasingly difficult-to-treat resulting in increased morbidity and mortality, especially for common infections such as urinary tract infections (UTIs). Globally, UTIs afflict over 400 million people a year. Numerous different gram-negative and gram-positive bacterial species cause UTIs, including uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae, and Acinetobacter baumannii. Many of these bacterial species are listed as pathogens of urgent concern by the Center for Disease Control due to the dangerous rise and prevalence of antibiotic resistance necessitating development of new therapeutic measures. Bacteria utilize adhesin factors, such as chaperone-usher pathway (CUP) pili to gain a foothold in …

Transgenerational Imprints Of Sequential Herbivory Onsoybean Physiology And Fitness Traits, Insha Shaft, Rupesh Kariyat

Entomology and Plant Pathology Faculty Publications and Presentations

Sequential herbivory leads to a multitude of effects on plants, influencing processes like growth, physiology, defense, and fitness. However, whether the sequential herbivore attack can elicit any transgenerational consequences is poorly examined. In this study, we show evidence of transgenerational impacts of sequential herbivory by two chewing herbivores, fall armyworm (Spodopterafrugiperda , FAW) and soybean looper (Chrysodeixis includens , SL) on soybean (Glycine max ) progeny. Seeds from the parents subjected to different herbivore sequences (SL-FAW: initial attack by SL followed by FAW and FAW-SL: FAW followed by SL) were used for the transgenerational experiment. Our main hypothesis was that …

Evaluation Of Different Resin-Based Barriers In Reducing Microleakage In Restoratively Compromised Posterior Teeth During Rubber Dam Isolation: An Ex Vivo Study, Carolina Becerra, Albert F. Mcmullen Iii, Joon Koh, Thomas E. Lallier

School of Dentistry Faculty Publications

Introduction: The rubber dam has been a standard in endodontic practice for over 140 years, providing critical isolation to prevent microbial contamination during root canal therapy. However, studies indicate that microleakage between the rubber dam and tooth structure may still occur, potentially leading to bacterial infiltration. Various resin-based barriers have been introduced to enhance isolation and minimize leakage. This study aimed to evaluate the efficacy of four resin-based barriers in reducing microleakage during endodontic procedures. Methods: Forty extracted human mandibular molars were selected, stored in distilled water, and standardized for experimental conditions. Standard endodontic access was created, and the mesiobuccal …

An Optimized Model For Identification Of Cerebral Palsy Using Deep Learning, Anjar Ahsan, Hassan Bin Mohammed, Abhilash Maroju, Nurhafizah Moziyana Mohd Yusop, Wan Su Emi Yusnita Wan Yusof, Najjah Salwa Abd Razak, Mohd Arif Dar

Polytechnic Journal

Cerebral palsy (CP), a neurological disorder that affects children and can occasionally result in cognitive problems as well as deficits in motor function can be caused by prenatal, perinatal, or postnatal factors. Each subtype of cerebral palsy (CP), such as spastic and non-spastic cerebral palsy, has distinct symptoms based on the location of the brain lesion and how it affects muscle tone. Individualized therapy and rehabilitation programs are necessary to treat these differences effectively. Therefore, early-stage CP categorization is crucial to ensuring timely and targeted treatment efforts. The functional magnetic resonance imaging (fMRI) of the infant's brain is a helpful …

Mic: A Deep Learning Tool For Assigning Ions And Waters In Cryo-Em And Crystal Structures, Laura Shub, Wenjin Liu, Georgios Skiniotis, Michael J Keiser, Michael J Robertson

Faculty, Staff and Students Publications

At sufficiently high resolution, x-ray crystallography and cryogenic electron microscopy are capable of resolving small spherical map features corresponding to either water or ions. Correct classification of these sites provides crucial insight for understanding structure and function as well as guiding downstream design tasks, including structure-based drug discovery and de novo biomolecule design. However, direct identification of these sites from experimental data can prove challenging, and existing empirical approaches leveraging the local environment can only characterize limited ion types. We present a representation of chemical environments using interaction fingerprints and develop a machine learning model to predict the identity of …