Digital Commons Network^™

Association Of Glucagon-Like Peptide-1 Receptor Agonists With Cancer Risk In Older Adults With Type 2 Diabetes, Ying Lu, Hao Dai, Huilin Tang, William T Donahoo, Thomas J George, Ramon C Sun, Sizun Jiang, Aik Choon Tan, Yi Guo, Jonathan D Licht, John M Allen, Kelvin P Lee, Jingchuan Guo, Jiang Bian

Faculty, Staff and Student Publications

Objective: The real-world evidence on the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cancer risk remains limited and mixed.

Methods: In 2013-2020 national Medicare claims data, we included cancer-naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP-1 RA, sodium-glucose cotransporter 2 inhibitor (SGLT2i), or dipeptidyl peptidase 4 inhibitor (DPP4i) and conducted 1:1 propensity score matching for confounding adjustment. Cox proportional hazards models were used to estimate hazard ratios (HR) of nine obesity-associated cancers (thyroid, pancreatic, bladder, colorectal, lung, kidney, breast, endometrial, and prostate cancer).

Results: In the matched GLP-1RA versus SGLT2i cohort (n = 21,362 …

Organizational Climate And Decision Aid Sustainability In Lupus Care: Mixed Methods Study, Aizhan Karabukayeva, Larry R Hearld, Nathan W Carroll, Reena Kelly, Jasvinder A Singh

Faculty, Staff and Students Publications

Background: Digital decision aids (DAs) are increasingly used in health care to support shared decision-making and promote patient engagement. In the context of systemic lupus erythematosus (SLE), a complex autoimmune disease characterized by diverse symptoms and uncertain prognoses, DAs offer guidance to patients in navigating treatment risks and benefits. Although numerous studies have examined the initial implementation of evidence-based tools, there is limited evidence on the organizational factors that influence their long-term sustainability in clinical practice. This gap is particularly salient for digital interventions, where integration into routine workflows and ongoing use require alignment with clinic readiness and culture. This …

Dclk1 Isoform (Dclk1-S) As A Critical Player In Promoting Inflammation, Tissue Remodeling, And Emt In Mouse Models Of Colitis., Kafayat Yusuf, Badal C. Roy, William L. Hauser, Mazin Al-Kasspooles, Sierra Sanchez, Thomas M. Attard, Dong Pei, Venkatesh Sampath, Shrikant Anant, Shahid Umar

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND AIMS: The Doublecortin-like kinase-1 (DCLK1) plays a chemosensory role in the gut. It's role in the context of inflammatory diseases including inflammatory bowel disease (IBD), has not been thoroughly investigated. This study explored the role of the DCLK1 isoform (DCLK1-S) in promoting infectious/chemical colitis by utilizing high-throughput imaging mass cytometry (IMC).

METHODS: Transgenic mice were either infected with Citrobacter rodentium (CR) or received DSS and tissues/cells were processed via standard techniques. IMC workflow was adapted by Fluidigm (renamed Standard BioTools). Raw data was fed to Multiplexed Cell Dataset (MCD) Viewer for image generation and analyzed via histoCAT. Promoters …

Prefrontal Cortex Astrocytes Modulate Distinct Neuronal Populations To Control Anxiety-Like Behavior, Eunyoung Kim, Hairuo Du, Yanqi Tan, Brandon L Brown, Yaowen Chang, Blanca Díaz-Castro, Jonathan V Sweedler, Xinzhu Yu

Faculty, Staff and Student Publications

Accumulating evidence has supported diverse regulatory functions of astrocytes in different neural circuits as well as various aspects of complex behaviors. However, little is known about how astrocytes regulate different neuronal subpopulations that are linked to specific behavioral aspects within a single brain region. Here, we show that astrocytes in the medial prefrontal cortex (mPFC) encode anxiogenic environmental cues in freely behaving mice. Silencing mPFC astrocyte Ca

Phase 1/2 Trial Of Encorafenib, Cetuximab, And Nivolumab In Microsatellite Stable Brafv600e Metastatic Colorectal Cancer, Van K Morris, Christine M Parseghian, Vahid Bahrambeigi, Nourhan Abdelfattah, Lianchun Xiao, Anjali Agrawal, Kangyu Lin, Kanwal P S Raghav, Robert A Wolff, Arvind Dasari, Ryan W Huey, Bryan K Kee, Michael J Overman, Jason A Willis, Phat H Le, Michelle Escano, Yunyu C Baig, Kelsey Pan, David Menter, Alda L Tam, Wai C Foo, Li Shen, Hey Min Lee, Thomas D Gallup, Cori Margain, Dave Gallup, Kimal I Rajapakshe, Paola A Guerrero, Jing Wang, Ryan B Corcoran, Anirban Maitra, Kyuson Yun, Scott Kopetz

Faculty, Staff and Student Publications

The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsatellite stable (MSS) BRAFV600E metastatic colorectal cancer (mCRC), characterized by higher immune activation than MSS BRAFwild-type colorectal cancer (CRC). In this phase 1/2 study (NCT04017650) of 26 participants with MSS BRAFV600E mCRC who received encorafenib, cetuximab, and anti-PD-1 antibody nivolumab, we report an overall response rate of 50% (95% confidence interval [CI] 29–71) and median progression-free survival of 7.4 months (95% CI, 5.6–9.6). Transcriptomic profiling of pretreatment biopsies and extracellular vesicle RNA (evRNA) isolated from plasma show …

Human Interpretable Grammar Encodes Multicellular Systems Biology Models To Democratize Virtual Cell Laboratories, Jeanette A I Johnson, Daniel R Bergman, Heber L Rocha, David L Zhou, Eric Cramer, Ian C Mclean, Yoseph W Dance, Max Booth, Zachary Nicholas, Tamara Lopez-Vidal, Atul Deshpande, Randy Heiland, Elmar Bucher, Fatemeh Shojaeian, Matthew Dunworth, André Forjaz, Michael Getz, Inês Godet, Furkan Kurtoglu, Melissa Lyman, John Metzcar, Jacob T Mitchell, Andrew Raddatz, Jacobo Solorzano, Aneequa Sundus, Yafei Wang, David G Denardo, Andrew J Ewald, Daniele M Gilkes, Luciane T Kagohara, Ashley L Kiemen, Elizabeth D Thompson, Denis Wirtz, Laura D Wood, Pei-Hsun Wu, Neeha Zaidi, Lei Zheng, Jacquelyn W Zimmerman, Jude M Phillip, Elizabeth M Jaffee, Joe W Gray, Lisa M Coussens, Young Hwan Chang, Laura M Heiser, Genevieve L Stein-O'Brien, Elana J Fertig, Paul Macklin

Faculty, Staff and Student Publications

Cells interact as dynamically evolving ecosystems. While recent single-cell and spatial multi-omics technologies quantify individual cell characteristics, predicting their evolution requires mathematical modeling. We propose a conceptual framework-a cell behavior hypothesis grammar-that uses natural language statements (cell rules) to create mathematical models. This enables systematic integration of biological knowledge and multi-omics data to generate in silico models, enabling virtual "thought experiments" that test and expand our understanding of multicellular systems and generate new testable hypotheses. This paper motivates and describes the grammar, offers a reference implementation, and demonstrates its use in developing both de novo mechanistic models and those informed …

Reducing Residential Landscape Water Use In Utah: Technologies And Strategies, Maya Cottam, Kendall Becker, Katlyn Stemmler, Shital Poudyal, Wesley Crump, Lewis Kogan, Scott Hotaling

All Current Publications

Water conservation is a critical issue in Utah, and several actions are already underway to help lower residential landscape water use. Strategies include smart irrigation controllers, efficient sprinkler bodies and nozzles, drip irrigation systems, soil amendments that increase water-holding capacity, and drought-tolerant grass cultivars for lawns. While additional conservation efforts will be necessary to reach sustainable water management, statewide adoption of current programs can help reduce water use and loss.

Molecular Identification Of Acinetobacter Baumannii Isolated From Clinical Samples In Iraq By Using Multiplex Pcr, Yaseen Ismael Mamoori, Ibrahim Abdulla Ahmed, May Ridha Jaafer, Ayat Muneam Ali, Sabreen Ali Hadi

Baghdad Science Journal

Acinetobacter baumannii is one of the most clinically significant pathogens that cause severe nosocomial infections. Rapid identification of this bacterial species is essential so that proper treatment can be provided and outbreaks can be controlled. In this study, a multiplex PCR was used to identify A. baumannii. Twenty clinical isolates of A. baumannii and three each of Gram+ve (Staphylococcus aureus, Bacillus licheniformis, Micrococcus yunnanensis) and Gram−ve (Proteus mirabilis, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacterial isolates were subjected to singleplex and multiplex PCR reactions using three sets of species-specific primers (P-Ab-ITS-F, P-Ab-ITS-R; …

Autonomous Driving Of A Guided Emergency Service Robot With Route Tracking Control, Saif Talib Abbas Albasrawi, Lamyaa Sabeeh Ashour Al-Lami

Baghdad Science Journal

This work presents a method for controlling the travel routes that tracked robots use to get around their environments. The algorithm utilized in model-predictive control could be implemented in a vehicle to make the vehicle capable of driving itself if an emergency arises. It is anticipated that soon, collaboration between edge clouds will become more commonly used to connect and control various pieces of rescue equipment. The Linear Model-Predictive Control algorithm, also known as LMPC, is an excellent choice for controlling the path that the rescue robots will take because it makes efficient use of the limited computational resources available …

Scorpions Of The Horn Of Africa (Arachnida: Scorpiones). Part Xliii. Lanzatus Fuscipalpis Sp. N. From Ethiopia (Buthidae), František Kovařík, Graeme Lowe

Euscorpius

The rare Horn of Africa buthid genus Lanzatus Kovařík, 2001, known only from Somalia and Somaliland, is recorded for the first time from Ethiopia. We describe a new species Lanzatus fuscipalpis sp. n. fully illustrated with color photographs showing its morphology, habitus, hemispermatophore, and collection sites.

Textbooks: Required, Alternatives, Hybrid, Or Disappearance, William Saunders, Carlton Perkins, Michara Delaney-Fields

Southwestern Business Administration Journal

The conversations around transformational changes in higher education are centered around a myriad of issues. Technology, the lasting effects of the pandemic, student satisfaction and readiness for future employment requirements are a few of the leading concerns. However, one subject that is not receiving enough attention is the growing resistance and hesitation among college students to purchase textbooks. Although the movement has not reached the status of a full-blown protest or outright refusal, there is enough attention being brought to the subject that educators may want to be prepared for an eventual change. The need and requirement for textbooks in …

Unheard And Underserved: The Role Of Narratives And Shared Experiences Of Systemic Racism In The Black Community’S Engagement With Mental Health Services, Essence Jones

Master of Arts in Human Services

This research examines the intersection of systemic racism and mental healthcare in the Black community, focusing on the reluctance to engage with mainstream services. Grounded in historical analysis, the study traces how slavery, segregation, and discriminatory policies have shaped enduring mistrust toward mental health systems. Despite progress in health equity initiatives, cultural insensitivity, underrepresentation of Black providers, and ongoing structural barriers persist. Drawing from peer-reviewed literature, the work explores narratives and collective memories that influence perceptions of care, including the role of faith-based coping, stigma, and alternative healing practices. Special attention is given to the compounded effects of intersectional identities …

Ineffective Parenting, Alexis Rian

Master of Arts in Human Services

Ineffective parenting can lead to long-term, severe, and lasting consequences for children. Children depend heavily on their primary caregivers for safety and to have their basic needs met. However, not all parents demonstrate positive parenting styles, whether due to a lack of knowledge, limited capacity, or simply a lack of interest. Parenting styles fall into four categories: authoritarian, authoritative, permissive, and uninvolved. The type of parenting style a caregiver adopts can significantly influence the attachment style a child has with them. Four attachment styles that children have are insecure avoidant attachment, secure attachment, insecure resistant attachment, and disorganized attachment. Children …

Underlying Causes Linking Foster Care And The Criminal Justice System, Marcia D. Wheeler

Master of Arts in Human Services

This research expands on the ongoing statewide crisis within the foster care system that needs to be properly addressed to benefit future and current foster youth. Research has found a connection between foster care and prison, often referred as the “foster-care-to-prison-pipeline.” This study aimed to explore the impact of trauma experienced by current and former foster youth through a life course lens looking at crucial areas of development using a mixed methodology supported by theoretical theories that explored the connection between foster care and the criminal justice system. The results showed that current and former foster youth face many adversities …

Synergistic Cefiderocol-Containing Antibiotic Combinations Active Against Highly Drug-Resistant Acinetobacter Baumannii Patient Isolates With Diverse Resistance Mechanisms, Justin Halim, Andrew P. Keane, Jeannete Bouzo, Tope Aderibigbe, Jessica A. Chicola, Katie T. Nolan, Keertana Jonnalagadda, Jason X. Tran, Valerie J. Carabetta

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Acinetobacter baumannii is a nosocomial pathogen known for rapidly developing resistance to nearly all antibiotics, including last-line agents. Cefiderocol, a novel siderophore cephalosporin, has shown in vitro activity against A. baumannii and is now used clinically, but resistance is emerging. Data on cefiderocol-based antibiotic combinations are limited.

OBJECTIVES: To evaluate the in vitro activity of cefiderocol alone and in combination with other antibiotics against XDR and PDR A. baumannii clinical isolates, and to explore resistance mechanisms underlying cefiderocol synergy.

METHODS: We tested 21 XDR/PDR clinical isolates and one NDM-1-producing strain using broth microdilution and checkerboard assays with cefiderocol and …

A Religious Etiology Of Genito-Pelvic Pain And Pain With Penetration, Emily L. Carlson

Theses and Graduate Projects

Pelvic pain during penetration (PPDP) has been described using various diagnostic terms, including vaginismus, dyspareunia, and vulvodynia. The most recent and comprehensive classification is Genito-pelvic pain/penetration disorder (GPPPD) which is characterized by psychological distress associated with pain during or in anticipation of vaginal penetration (DSM-5-TR; American Psychiatric Association [APA], 2022). The etiology of PPDP is multifactorial, involving a complex interplay of biological, psychological, and relational factors. Religious and cultural influences may play a significant role in shaping individuals’ experiences of sexual pain. This study investigated the etiology of PPDP in relation to the religious influences among women raised in Judeo-Christian …

Improving Student Success In 2nd Degree Bsn Students, Sharon Radzyminski, Eloisa G. Tamez, Jennifer Brewster, Leslie Kimberling Jones

School of Nursing Faculty Publications

Second Degree Bachelor of Science in Nursing (BSN) programs are designed to leverage a student’s prior academic achievements and professional experience, integrating them into the curriculum for their nursing degree. This allows students to receive credit for previous core courses and move through the nursing program at an accelerated rate. This, however, brings special challenges for both students and faculty. At our university we noticed the attrition rate of students in the second-degree BSN program was significantly higher than the traditional BSN program. Investigation into this issue revealed students in the Second-Degree Program had significant issues with role conflict, poor …

Menopause-Related Changes In Sleep And The Associations With Cardiometabolic Health: A Narrative Review, Joshua R. Sparks, Xuewen Wang Ph.D., Faha

Faculty Publications

This narrative review examines the complex relationship between sleep changes during the menopausal transition and cardiometabolic risks. The most common complaint about sleep is increased awakenings during sleep. Other complaints include having trouble falling asleep, waking up too early, insufficient and non-restorative sleep, and overall poor quality. Sleep determined using objective methods also indicates that greater awakenings after sleep onset are associated with the period of menopausal transition. Polysomnography recordings suggest physiological hyperarousal during sleep. Changes in other sleep metrics, such as sleep latency and sleep duration, are less consistent, and some studies suggest they may not worsen during the …

Dynamic Remodeling Of Centrioles And The Microtubule Cytoskeleton In The Lifecycle Of Chytrid Fungi, Alexandra F Long, Krishnakumar Vasudevan, Andrew Swafford, Claire M Venard, Jason E Stajich, Lillian K Fritz-Laylin, Jessica L Feldman, Tim Stearns

Biology Faculty Publications

Cell movement and division are complex behaviors driven by a dynamic internal cytoskeleton. The molecular components and principles of cytoskeletal assembly are well studied, but less is known about cytoskeletal remodeling events, including how centrioles transition from ciliary base to centrosome. Here we address this using the chytrid Rhizoclosmatium globosum, a zoosporic fungus which has centrioles and cilia, lost in most fungal lineages. Chytrids undergo reorganization of their microtubule cytoskeleton as they grow from zoospore to multinucleated coenocyte. We use evolutionary comparison, RNA sequencing, and expansion microscopy to understand this reorganization and further develop this organism as a model for …

High Abundances Of Crustose Coralline Algae Inside Cryptic Coral Habitats Linked To Coral Reef Functioning, Anna Rothstein, Orion S. Mccarthy, Sophie Luu, Emily L.A. Kelly, Philip Heller, Stuart Sandin, Jennifer E. Smith, Maya S. Devries

Faculty Research, Scholarly, and Creative Activity

Cryptic habitats on coral reefs consist of crevices, tunnels, and holes that are estimated to comprise 30%–75% of the total reef surface area. These large habitats are vastly understudied because they are often difficult to access. Crustose coralline algae (CCA) are thought to perform important ecological functions, including calcium accretion, both inside cryptic habitats and on the exposed (top) reef. Using GoPro cameras, we surveyed 250 coral crevices from 13 reefs on West Maui, Hawai‘i. We compared relative CCA cover between crevice microhabitats and the well-studied top-reef and identified abiotic and biotic factors that correlated with CCA abundance. We found …

Late Holocene Paleodietary Patterns Among The Ancestral Ohlone: Ecogeographic Partitioning Of Resources Along The San Francisco Bay Eastern Shore, Melanie M. Beasley, Eric J. Bartelink, Alan Leventhal, Monica V. Arellano, Richard Massiatt, Charlene Nijmeh

Faculty Research, Scholarly, and Creative Activity

Objectives: In the San Francisco Bay Area, Late Holocene resource intensification models predict an increase in diet breadth and a reduction in foraging efficiency associated with an increase in population, sedentism, and territoriality among fisher-hunter-gatherer populations. Here we compare bone stable carbon (δ¹³C) and nitrogen (δ¹⁵N) isotope values of sites along the eastern bay shore to interpret how ecogeographical partitioning of resources by latitude and distance from the bay reflects differential access and control of resources. Materials and Methods: With the support of, and in collaboration with, the Muwekma Ohlone Tribe of the San Francisco Bay …

Current Mechanobiological Pathways And Therapies Driving Spinal Health, Rahul Kumar, Kyle Sporn, Harlene Kaur, Akshay Khanna, Phani Paladugu, Nasif Zaman, Alireza Tavakkoli

SKMC Student Presentations and Publications

Spinal health depends on the dynamic interplay between mechanical forces, biochemical signaling, and cellular behavior. This review explores how key molecular pathways, including integrin, yeas-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), Piezo, and Wingless/Integrated (Wnt) with β-catenin, actively shape the structural and functional integrity of spinal tissues. These signaling mechanisms respond to physical cues and interact with inflammatory mediators such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), driving changes that lead to disc degeneration, vertebral fractures, spinal cord injury, and ligament failure. New research is emerging that shows scaffold designs that can …

Travel Professionals’ Successful Strategies For Implementing New Products, Mary Ashley Switzer

Walden Dissertations and Doctoral Studies

The rapid introduction of new and innovative travel products presents challenges for travel industry professionals striving to stay competitive in a dynamic marketplace. This is a significant concern for travel professionals and industry leaders, as effectively implementing strategies can improve client satisfaction and support sustained business growth. The purpose of this qualitative pragmatic inquiry study was to explore the strategies used by travel industry professionals to successfully implement new, innovative tourism products to gain a competitive advantage. Grounded by the Red Queen effect competitive advantage model, six U.S.-based travel professionals with 5 years of experience and at least $1 million …

Tmco1 As An Endoplasmic Reticulum Calcium Load-Activated Channel: Mechanisms And Disease Implications, Jingbo Wang, Panpan Zhu, Zhuohang Li, Xiaohui Su, Mingzhu Qi, Aimin Zhou, Xiangying Kong

Chemistry Faculty Publications

Calcium ions (Ca2+) play a vital role in many biological processes. Transmembrane and coiled-coil domain 1 (TMCO1) has been characterized as an endoplasmic reticulum (ER) transmembrane protein in recent years. It keeps the cytoplasm and ER's Ca2+ homeostasis stable by acting as a novel calcium channel. Studies from different laboratories have revealed that the mutation or deficiency of TMCO1 is closely correlated with several diseases, including cerebro-facio-thoracic dysplasia (CFTD), glaucoma, premature ovarian failure (POF), osteoporosis, and cancer. Here, we review the characteristics of TMCO1 and its involvement in related diseases, which may provide useful information for developing therapeutic strategies for …

Use Of Cigarettes, Cannabis, And Alcohol Among Asian American, Native Hawaiian, And Pacific Islander Adults: Community-Based National Survey Analysis, Vuong Van Do, Van My Ta Park, Nhung Nguyen, Pamela May Ling, Marian Tzuang, Bora Nam, Marcelle M. Dougan, Oanh L. Meyer, Janice Y. Tsoh

Faculty Research, Scholarly, and Creative Activity

Background: Asian American, Native Hawaiian, and Pacific Islander (AANHPI) populations have diverse cultural, immigra-tion, and sociodemographic characteristics. Aggregated data could mask substantial differences in substance use between cultural subgroups in this population. Yet, studies examining substance use among the AANHPI population are limited. Objective: This study aimed to describe cigarette, cannabis, and alcohol use among AANHPI adults by cultural subgroup and sex. Methods: We analyzed data from 3411 AANHPI respondents of a multilingual national survey “COMPASS” during December 2021-May 2022. Primary outcomes were self-report current (every day or some days) use of cigarettes, cannabis, and alcohol. Cultural subgroups included Asian …

Faculty Panel: Ideas For Introducing Your Syllabus, Liz Norell

Events

Spending the first day of class marching through the syllabus doesn’t exactly set the stage for an engaged classroom environment, but the information in the syllabus is important. Given that, what do we do instead? In this panel discussion, we’ll hear from several instructors about how they introduce the syllabus at the start of a new semester. Attendees will leave with multiple examples of how to engage students in a more interactive review of the syllabus that builds community and sets the tone for an engaged classroom environment.

Polymeric Nanocarriers Functionalized With Peptides For Improved Glioblastoma Targeting And Blood–Brain Barrier Permeability, Cristian Antonio Wieczorek Villas Boas, Aaron Priester, Buck E. Rogers, Anthony J. Convertine

Materials Science and Engineering Faculty Research & Creative Works

We report the synthesis of polymeric conjugates designed to penetrate the blood–brain barrier (BBB) and selectively bind glioblastoma (GBM) cells through reversible addition–fragmentation chain transfer (RAFT) polymerization. The resulting materials were engineered to contain peptide macromonomers for cell-specific targeting and integrated DOTA units to facilitate radiolabeling with copper-64 (⁶⁴Cu), yielding radiolabeled conjugates with greater than 95% radiochemical purity. In biodistribution assessments conducted in mice, C1C2 peptide-conjugated polymers showed significantly improved accumulation in brain tissue, supported by brain perfusion analyses confirming efficient BBB penetration. Additionally, flow cytometry evaluations demonstrated specific affinity of GBM-targeted polymer formulations toward U87 glioblastoma cells. …

Temporal Trends Of A Cellular Host Response Test For Sepsis And A Comparison With Selected Biomarkers Of Inflammation And Infection, Matthew S. Berlinger, Matt Sorrells, Christopher B. Thomas, Tonya Jagneaux, James E. Walker, Jennifer Daigle, Heather Quiriarte, Youyoung Kim, Guillaume Spielmann, Debbie Robertson, Susan Park Ochsner, Gideon Avornu, Katherine Fenstermacher, Elijah James Kurien, Camille King, Adenine Cembellin-Kao, Chase Yonamine, Querino Maia, Maciej Obrebski, David N. Hager, Roya Sheybani, Henry T.K. Tse, Ajay M. Shah, Robert Scoggins, Hollis R. O’Neal, Richard Rothman

School of Medicine Faculty Publications

Sepsis, a condition characterized by immune dysregulation, is the leading cause of in-hospital mortality and requires rapid treatment. Assessing immune dysregulation has been challenging. The IntelliSep Index (ISI), a novel biomarker which leverages microfluidic deformability cytometry to assess immune activation, has been evaluated as a test for Emergency Department use but it is unclear how the signal evolves as patient condition evolves. In a 47-patient cohort with hospital stays ≤ 14 days, ISI provided a good indicator of disease progression by blinded physician review. ISI trends correlated with clinical improvement over time. During the first 12 h following presentation, ISI …

Working Group Report: Developing A Playbook Of Equitable Grading Practices, Stephen H. Edwards, David L. Largent, Ben Schafer, Debarati Basu, Amy Csizmar Dalal, Dan Garcia, Brian Harrington, Kevin Lin, Dan S. Myers, Christian Roberson, Giulia Toti, Brett Wortzman

Faculty Publications

Traditional points-based grading can have negative impacts. As a result, many educators are experimenting with alternative grading practices that are more equitable for students. However, educators often face challenges in implementing equitable grading practices due to a lack of clear, practical descriptions of techniques and the fact that not all techniques are universally applicable. This working group addresses this problem using a three-pronged strategy: conducting a systematic literature review to gather documented techniques, compiling ''recipes'' or concrete descriptions of these techniques, and publishing them in an open-source, online ''playbook'' of equitable grading practices as a community resource for educators. This …

Magnetic Ordering And Dynamics In Assemblies Of Magnetite Nanoparticles Throughout The Superparamagnetic Transition, Johnathon Michael Rackham

Theses and Dissertations

Magnetic nanoparticles are used in nanotechnologies and biomedical applications, such as drug targeting, hyperthermia treatment, MRI contrasting agents, and bio-separation of compound solutions. Magnetite (Fe3O4) nanoparticles stand to be effective in these roles due to the non-toxic nature of magnetite and its strong magnetization. To this end, a greater understanding of the magnetic behavior of the individual magnetite nanoparticles is needed when a collection of them is used. This research seeks to discover the local magnetic ordering and dynamics of fluctuations of ensembles of magnetite nanoparticles at various stages of the magnetization process, throughout the superparamagnetic blocking transitions, and for …