Digital Commons Network^™

Ectopic Adipose Tissue In Subsistence Populations With Minimal Coronary Disease, Large Left Atria, And Very Low Rates Of Atrial Fibrillation, Randall C. Thompson, Benjamin C. Trumble, Daniel K. Cummings, Angela D. Neunuebel, Paul L. Hooper, Samuel Wann, Adel H. Allam, Frances Neunuebel, Benjamin D. Gans, Samantha I. King, Edmond Seabright, Caleb E. Finch, Margaret Gatz, Kenneth Buetow, Michael I. Miyamoto, Guido P. Lombardi, M. Linda Sutherland, James D. Sutherland, Christopher J. Ward, Madeleine J. Lee, Ashna Mahadev, Daniel Eid Rodriguez, David E. Michalik, Chris J. Rowan, Tianyu Cao, Jonathan Stieglitz, Cameron M. Quick, Gregory S. Thomas, Jagat Narula, Damini Dey, Michael Gurven, Hillard Kaplan

ESI Publications

Background

Methods

Innovative Approaches To Estimating Sessile Oak Stem Volume: Comparing Additive Models And Ensemble Machine Learning, Maria J. Diamantopoulou, Abbas Şahi̇n, Ramazan Özçeli̇k

Turkish Journal of Agriculture and Forestry

Sessile oak is an important deciduous forest tree species across Türkiye and Europe. Estimating individual tree and stand volumes is essential for growth and yield models, as these predictions play a critical role in assessing forest management, economics, and fire risk. In pursuit of this goal, nonlinear seemingly unrelated regression (NSUR) was used for the simultaneous fitting of stem volume components, and compared to three ensemble machine learning techniques: gradient boosting regression (GBr), XGBoost regression (XGBr), and random forest regression (RFr). NSUR accounts for correlations between error terms across different equations, leading to more efficient parameter estimates than if each …

Engineering Protein Linkers For Optimized Telsam-Darpin Fusion And Crystallization With Electric Field-Based Polymer Orientation, Maria Jose Pedroza Romo

Theses and Dissertations

Fusing a variant of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest significantly enhances crystallization and diffraction quality. TELSAM is a pH-dependent, polymer-forming crystallization chaperone that, when covalently fused to a protein, forms a well-ordered crystal lattice. However, the success of this method depends on two factors: 1) the design of the linker connecting TELSAM to the target protein, which influences both crystal packing and target orientation, and 2) the prevention of TELSAM polymer flipping, a phenomenon that disrupts lattice periodicity and impairs structure determination. To address the first challenge, …

Cost-Effectiveness Model For Reservoir Sediment Management Economics, Connor Ronald Hale

Theses and Dissertations

Reservoir sediment deposition poses a challenge to sustainable water supplies around the world. Sediment management has proven to be an expensive endeavor. Two models have been developed to guide economic analysis for reservoir sediment management, namely the Reservoir Sediment Economics Model (RSEM) and the Reservoir Conservation Model 2 (RESCON 2). While these are helpful tools for benefit-cost prefeasibility studies, they rely heavily on sometimes elusive estimations of the benefits of water supply. In this study, a new method for economic analysis is proposed that foregoes benefit-cost analysis in favor of a cost-effectiveness approach. The Sediment Management Cost-Effectiveness Model ranks sediment …

A 6-Month, Prospective Randomized Controlled Trial Of The Targeted Management (Team) Intervention Vs. Enhanced Treatment As Usual Among Ugandans At Risk For Stroke, Carla Conroy, Joy Yala, Christopher J. Burant, Shirley Moore, Martha Sajatovic

Faculty Scholarship

Background Among low and middle-income countries, especially in Sub-Saharan Africa, the stroke burden is severe, with increasing trends in stroke incidence, prevalence, and mortality. Aims This 6-month, prospective randomized controlled trial (RCT) compared a novel stroke risk reduction approach (TargetEd manAgeMent Intervention (TEAM)) vs. Enhanced Treatment as Usual (ETAU) in 247 Ugandans at risk for stroke. Methods Participants, enrolled across 3 Ugandan sites, were adults with high stroke risk. The primary outcome was a change in systolic blood pressure (SBP) from baseline to 6-month follow-up. Secondary outcomes included changes from baseline to 6 months on diastolic BP (DBP), serum lipids, …

Prediction Of Drug-Induced Cardiotoxicity Using Machine Learning Analysis Of Hipsc-Cm Contractile Profiles, Anthony Allan Watt

Theses - ALL

Drug-induced cardiotoxicity remains a critical concern in pharmaceutical development as failed drug candidates result in lost time and resources that could be better spent on viable candidates. We believe that a robust in vitro model that accurately captures human cardiac physiology is an applicable model for examining drug candidates. In addition to those models, there is a need for quick and effective predictive models to analyze data obtained from the model to classify drugs based on their potential for cardiotoxicity. In this study, we conduct a functional analysis of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and pass the data collected …

Decreasing Foraminiferal Flux In Response To Ongoing Climate Change In The Santa Barbara Basin, California, Emily Harvard, Katherine Cherry, Claudia R. Benitez-Nelson, Eric Tappa, Catherine V. Davis

Faculty Publications

The rapid response of foraminiferal assemblages to changing climate makes their shells an invaluable geological record of the past. However, the time frame over which foraminifera respond to climatic signals and the specific drivers influencing assemblage composition and abundance remain obscure. We focus on the impact of ongoing, anthropogenic climate change on planktic foraminifera in the California Current ecosystem, which would appear as a nearly instantaneous event in the sediment record. The Santa Barbara Basin sediment trap, located off the coast of California, USA since 1993, provides a record of more than 30 years of particulate and foraminiferal flux in …

In Defense Of Metaphysics: A Defense Of The Value And Methodological Soundness Of Metaphysics Understood As Structural Modeling, Sean Nalty

Dissertations - ALL

The aim of this dissertation is to provide a defense of the value and methodological soundness of contemporary analytic metaphysics against a variety of recent anti-metaphysical and scientistic critiques. In Chapter 1, I attempt to answer (at least provisionally) a surprisingly difficult question: what is metaphysics, anyway? I suggest seven adequacy constraints on an answer to this question, and then test five historically and contemporarily influential candidate characterizations of metaphysics against these constraints. Finding each candidate lacking, I close by proposing an ecumenical conception of metaphysics — what I call the structural modeling conception — according to which metaphysics aims …

Challenging Life Events Of Undergraduate Students, Kristi Lewis, Gayle Roux, Catherine Dingley

The Qualitative Report

College students often face many difficult or stressful personal life events such as academic pressure, financial worries, family stress, or a relationship breakup. These events can impact their mental health and academic performance. Amid the growing mental health crisis on college campuses, it is important to explore the strategies that college students employ to tackle challenging life events. The purpose of this study was to (1) explore the experience of college undergraduates as they navigate challenging life events; and (2) examine strategies and resources utilized by the students. We conducted a qualitative descriptive study informed by phenomenology (Giorgi, 2009) using …

Premenopausal And Postmenopausal Malignant Cervical Cancer Diagnosis Among Disaggregated Subethnic Groups Of Asian American Women In The United States, Nilofar Haider Mirza

Walden Dissertations and Doctoral Studies

Despite being the United States' fastest-growing and diverse population, Asian Americans are often aggregated with Native Hawaiian and Pacific Islanders in prior research, resulting in masking disparities in cervical cancer screening/diagnosis among Asian American subethnic groups. Guided by Bronfenbrenner's ecological model, the association between disaggregated subethnic groups and cervical cancer diagnosis among Asian American women aged 20+ in the United States was examined using binary logistic regression. How histology type/behavior and age at diagnosis moderate the relationship between disaggregated subethnic groups and cervical cancer diagnosis was also explored. A quantitative cross-sectional design was employed using cases (N=1014) from the U.S. …

Exposure-Inducible Genes May Contribute To Missingness In Rnaseq-Based Gene Expression Analyses, Olga Y Gorlova, Ivan P Gorlov, R Taylor Ripley, Chao Cheng, Yafang Li, Bo Peng, Yanhong Liu, Hee-Jin Jang, Sung Wook Kang, Claire Lee, Priyanka Ranchod, Bryan M Burt, Hyun-Sung Lee, Christopher I Amos

Faculty, Staff and Students Publications

Missing gene expression values are a common issue in RNAseq-based analyses of gene expression. However, an analysis of genetic and environmental factors contributing to data missingness in RNAseq-based assessment of gene expression has never been conducted. In this study we tried to identify factors in RNAseq data missingness. We used RNAseq data from 66 lung adenocarcinoma tumors and corresponding adjacent normal lung tissues. We found a strong negative association between the gene expression level and missingness, supporting the idea that the borderline expression level is a key contributor to missingness. In a more detailed analysis, the relationship between gene expression …

Assessment Of Bat Species (Mammalia: Chiroptera) In Canubas Cave, Kibawe, Bukidnon, Philippines, Jurriel Mari D. Alce, Jasmine Rouida M. Abenes, Leo Gabriel Cervantes, Matthew Eli K. Llacer, Von Zhyrus P. Oche, Ian Jay P. Saldo, Jhovel Roy D. Calo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Bats, flying mammals, are essential to ecosystems, playing vital roles in pollination, seed dispersal, and insect control. Despite their ecological importance, no prior bat research exists for Canubas Cave, Kibawe, Bukidnon. This study aimed to assess the bat species at the site, documenting their morphometric data, diversity and richness indices, and conservation statuses. A purposive sampling design was implemented by setting up mist nets inside and outside the cave. A total of 13 individuals were identified, comprising three species from two families: Rousettus amplexicaudatus and Eonycteris spelaea (family Pteropodidae, fruit bats), and Miniopterus schreibersii (family Miniopteridae, bent-winged bats). Based on …

Milkfish (Chanos Chanos) Bones As A Biosorbent For Mercury (Ii) Contamination In Water, Seth Uriel K. Neri, Ethan Kyle Mangao, Christian Kevin F. Redoblado, Anthony Cesar Y. Ponce, Roby Boy P. Riego, Jupiter O. Yap

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Heavy metals, such as mercury contamination in water sources are a major environmental and public health issue in many countries. Traditional methods for removing heavy metals from water are effective but often costly and unsustainable and may produce secondary waste. Recent trends favor more sustainable alternatives, such as biosorbents in treating water with heavy metals. Milkfish (Chanos chanos), a common fish in the Philippines, contains hydroxyapatite in the bones that can bind with heavy metals through physical and chemical adsorption mechanisms. This study aims to evaluate the mercury (II) reduction capacity of biosorbent derived from milkfish bones in water, specifically …

Satellite-Based Identification Of Mesoscale And Submesoscale Eddies And Fronts In The Gulf Of Mexico, Ethan Cruz

Theses and Dissertations

Mesoscale and submesoscale processes in the Gulf of Mexico (GoM) are fundamental in shaping the region’s physical and biogeochemical ocean dynamics. Advances in high-resolution satellite observations now allow detailed detection of submesoscale (< 25 km radius) and mesoscale eddies and ocean fronts, which drive heat, nutrient, and carbon fluxes. This dissertation integrates two complementary investigations: (1) a comparison of eddy-tracking algorithms: Contour Tracing (CT) and Temperature Thresholding (TT), applied to Optimum Interpolation Sea Surface Temperature (OISST, 1/4°) and Operational Sea Surface Temperature and Ice Analysis (OSTIA, 1/20°) products; and (2) a comparative evaluation of three ocean front detection algorithms: Canny Edge Detection (Canny), the Cayula–Cornillon Algorithm (CCA), and the Belkin–O’Reilly Algorithm (BOA), across multiple satellite-derived parameters, including sea surface temperature (SST), sea surface salinity (SSS), chlorophyll-a (Chl-a), and altimetry-derived absolute dynamic topography (ADT). The eddy-tracking analysis shows that the higher-resolution OSTIA consistently detected more eddies than OISST, with TT performing best during winter when SST gradients were strongest. The front detection analysis, incorporating datasets from the Surface Water and Ocean Topography (SWOT) and Plankton, Aerosol, Cloud, Ocean Ecosystem (PACE) missions, was evaluated under diverse conditions, including flood and drought periods, Loop Current phase changes, and extreme weather events. A machine learning–based Gaussian Mixture Modeling (GMM) approach was also developed, providing a novel framework for dynamic front detection. By benchmarking traditional and machine learning methods, this integrated study identifies optimal algorithm–dataset combinations for resolving submesoscale and mesoscale features in the GoM, with applicability to other regions.

Black Mothers' Adhd Experiences, Attitudes, And Support-Seeking Decisions, Catherine L. Montgomery

Dissertations - ALL

Background: ADHD, particularly when left untreated, is associated with significant impairment in several domains. Black youth may still be under-diagnosed with ADHD, resulting in symptoms going untreated. Black mothers may determine non-professional delivered supports to be more appropriate and acceptable than medication for their children with ADHD. As they tend to be the primary healthcare decision makers, it is important to develop a greater understanding of Black mothers’ ADHD support-seeking decision making for their youth. Method: The present study used semi-structured interviews guided by Kleinman’s Explanatory Models of Illness to discuss Black mothers’ decision making for their youth with ADHD. …

The Impact Of Adhd On Entrepreneurship Through A Gender Lens Three Essays, Mi Hoang Tran

Dissertations - ALL

This dissertation investigates how neurodiversity, specifically attention-deficit/hyperactivity disorder (ADHD), relates to entrepreneurial behaviors and outcomes, with a specific attention to gender as a moderating factor. The first essay provides a comprehensive meta-analytic review of 44 empirical studies, synthesizing 261 effect sizes to assess the relationship between ADHD and different stages of the entrepreneurial process: attitudes, behaviors, and post-launch outcomes. Results reveal that hyperactivity/impulsivity symptoms are positively associated with entrepreneurial attitudes and behaviors but unrelated to post-launch outcomes, while inattention symptoms are negatively associated with outcomes. These findings offer evidence that ADHD’s impact is phase-specific and contingent. The second essay draws …

Technological Revolutions And Advertising: Historical Innovation Cycles, Ai, And The Future Of Platform Power, Christopher J. Lorusso

Dissertations - ALL

This study explores the future of advertising amidst a digital landscape increasingly shaped by artificial intelligence (AI). Leveraging Carlota Perez’s Technological Revolutions and Financial Capital framework, it examines how AI is poised to further disrupt the advertising ecosystem through the key elements of automation, user data, and inventory. Collectively, these dynamics have become key drivers of platform power, with implications for user behavior, competitive strategy, and the societal diffusion of AI technology more broadly. Employing a thematic analysis across historical and contemporary cases of advertising technology, the research identifies five themes worthy of strategic and scholarly consideration. Two primary themes—Dependency …

Caf-Macrophage Crosstalk Fuels Immunotherapy Resistance, Yang Liu, Linghua Wang

Faculty, Staff and Student Publications

No abstract provided.

Targeting Fear Of Cancer Recurrence With Internet-Based Emotional Freedom Techniques (Ieft) And Mindfulness Meditation Intervention (Immi) (Bgog-Gyn1b/Remote), Laura Tack, Lore Mertens, Marte Vandeweyer, Fien Florin, Emma Pauwels, Thaïs Baert, Tom Boterberg, Christel Fontaine, Kurt Geldhof, Caroline Lamot, Christine Langenaeken, Jeroen Mebis, Laure-Anne Teuwen, Katherine Vandenborre, Heidi Van Den Bulck, Florence Van Ryckeghem, Mohammad Najlah, Patricia Schofield, Philip R. Debruyne

School of Nursing and Midwifery

Approximately one-third of cancer survivors report a need for professional help to cope with Fear of Cancer Recurrence (FCR). In the REMOTE trial, we aim to investigate the efficacy of two internet-based mind-body techniques to address this currently unmet medical need. Cancer survivors, screened using the Cancer Worry Scale (CWS), are randomly assigned to one of the three study groups: (1) internet-based emotional freedom techniques (iEFT) (n = 113), (2) an active control condition internet-based mindfulness meditation intervention (iMMI) (n = 113), or (3) a wait-list control group (WLC) (n = 113). The interventions iEFT and iMMI are conducted remotely …

Multivariate Protein Landscape Of Host Response In Hospitalised Patients With Suspected Infection In The Emergency Department, Pratik Sinha, Et Al.

2020-Current year OA Pubs

Suspected infection requiring hospitalisation has highly heterogenous presentation. Yet, variances in host response and its implications are largely unknown. In this multicentre cohort of 3802 individual patients presenting to the Emergency Department (ED) with suspected infection requiring hospitalisation, we apply uniform manifold approximation and projections and K-means clustering to 29 plasma proteins to identify biologically discrete host response clusters. In this work, we first describe two large clusters, called "Dysregulated" and "Undifferentiated", with abnormal protein concentrations and adverse outcomes in the former. Through further clustering, we identify 4 sub-clusters in the Dysregulated cluster, each with discrete biological signatures, clinical correlates, …

Counselor-In-Training Perceptions Of Artificial Intelligence: Implications For Counselor Education, Leo Gonzalez Jr., Deija Mccalla

Journal of Counselor Preparation and Supervision

This study examined the perceptions of counselors-in-training (CIT) on artificial intelligence (AI) in counseling practice and training. 31 CIT responded to three open-ended questions about the benefits, drawbacks, and overall attitudes of integrating AI into counseling practice and education. Thematic analysis was used to analyze the responses. The findings showed that CIT perceive AI as a clinical support tool, especially for tasks such as diagnosis and treatment planning. Additionally, CIT voiced concerns of potential overreliance on AI, ethical risks, confidentiality concerns, and the possible loss of human connection. Furthermore, although several CIT expressed cautious optimism regarding AI's use in counselor …

Integrating Artificial Intelligence In A University Counseling Clinic, Donna S. Sheperis, Shiri Sharvit

Journal of Counselor Preparation and Supervision

Artificial intelligence (AI) is increasingly used in mental health care, yet counseling students receive little training in digital tool integration. This program evaluation describes the use of an ambient AI platform in a university telemental health clinic to support clinical training. The AI system tracked interventions, themes, talk ratios, and symptom changes across 175 sessions by 13 trainees with 93 clients. Most frequent interventions included validation (97.6%), CBT skills (52.1%), and action planning (63.1%). Counselor talk time averaged 43% of the session, with themes such as relationships and school being predominant in client talk time.. By session 7, clients showed …

Utilizing Artificial Intelligence Therapeutic Adjuncts To Support Autistic Adults Between Counseling Sessions, Carlos J. Castaneda Jr, Nicole Noble, Afroze N. Shaikh

Journal of Counselor Preparation and Supervision

The integration of artificial intelligence (AI) into mental health care presents innovative opportunities for therapeutic interventions. This pilot study examined the use of a customized Artificial Intelligence Therapeutic Adjunct (AITA) as a supplementary counseling tool for adults with level one autism spectrum disorder who attended weekly counseling sessions. Using a Single Subject Design to review trends in mental health symptoms and perceptions of the AITA, participants engaged with the AITA over four weeks, completed weekly anxiety and depression assessments, and post-intervention and satisfaction surveys. Thematic Analysis identified common counseling concerns and the AITA’s use of counseling techniques. Although findings suggest …

I Refugee: Memories, Alicia Garza

Cuaderna Vía

No abstract provided.

Full Issue, Cuaderna Vía Editors

Cuaderna Vía

No abstract provided.

Research Synthesis Of Predicting Part 135 Accident Probability In Aviation: How The Bayesian Brain Ignores Declining Safety Standards, Jonathan R. Clarke

Journal of Aviation Technology and Engineering

Technological innovation has had an enormous effect on safety in aviation. However, in Part 135 operations, where technology is not as ubiquitous, the accident rates have plateaued. Human error is constantly misrepresented as being responsible for 70–80 percent of accidents, when it is clearly only one of several contributing factors. In commercial aviation, all accidents should be considered organizational failures, because by definition all defensive layers have been breached. Organizational failure, as it affects safety, should be identifiable and predictable from organizational behavior. Inevitably, in the aftermath of accidents the warning signs of poor behavior are seemingly obvious, yet there …

Contaminated Water And Health Inequities: A Review Of Disparities In Low-Income Populations, Esraa Hussein, Rachel Chung, Chelsea Kim, Jackie Lucas, Erica Kim, Kinsley Wilson, Jasmine Sholy, Rahma Fares, Sharon Ojo, Yashitha Teekaraman, Melane Pira, Bellana Schlosser

General Submissions: Community and Population-based Materials

What are the most reported healthcare disparities associated with exposure to contaminated water in low-income and under-resourced communities?

Objectives: To identify and analyze the most commonly reported healthcare disparities associated with exposure to contaminated water in low-income and under-resourced communities. This research aims to understand how environmental contamination disproportionately impacts healthcare access and outcomes in marginalized populations.

Background: Low-income and under-resourced communities are disproportionately affected by the ongoing global health threat of contaminated water exposure. Pollutants like heavy metals, pathogens, and industrial runoff cause preventable illnesses like skin infections, developmental disorders, and gastrointestinal disorders. Systemic healthcare disparities, such as limited …

In Silico Investigation Of The Anticancer Activity Of Natural Isoquinoline Alkaloids Targeting The Monoamine Oxidase A Enzyme, Reham A. Al-Anssari, Anwar H. Ali, Ola Adel Al-Saad, Shaker A.N. Al-Jadaan

AUIQ Complementary Biological System

Monoamine oxidase A (MAO-A) has recently been identified as a candidate for cancer therapy due to its roles in tumor development and growth. Conventional approaches for the discovery of MAO-A inhibitors are both costly and time-consuming. The objective of this work was to apply in silico methods to predict natural isoquinoline alkaloids capable of acting as potent MAO-A inhibitors, and to establish this class of compounds as potential sources of a cost-effective anticancer therapy. Twenty-one natural isoquinoline alkaloids were subjected to a multistep computer-aided drug discovery protocol. The compounds were initially screened for pharmacokinetic (ADME), toxicity, and drug-likeliness properties by …

To Protect And Survive: Acknowledging Adverse Childhood Experiences In Law Enforcement, Melanie Appleman

Master of Arts in Human Services

This literature review explores the influence Adverse Childhood Experiences (ACEs) can have on choosing a helping profession as well as their effect on law enforcement personnel and their ability to cope with occupational trauma. Law enforcement officers are routinely exposed to high-stress, high-risk environments which can exacerbate underlying trauma stemming from early life experiences. Officers with a history of ACEs may be more vulnerable to emotional dysregulation, hyper-vigilance, burnout, and substance abuse which can influence their decision making, relationships, and professional conduct potentially resulting in negative outcomes. Key themes include the identification of risk factors, the development of screening tools, …

Assessing Cascaded Op-Amp And Pre-Current Amplifier Configurations In Transimpedance Amplifier Interfacing Circuits For Nano-Scale Current-Based Sensor Applications, Mohamed Mamdouh, Sameh O. Abdellatif

Electrical Engineering

This study provides a comprehensive analysis of two proposed configurations for current-to-voltage converters tailored for nano-scale current-based sensor applications, focusing on key performance metrics such as linearity, dynamic range, DC noise immunity, and power losses. The evaluation employed frequency-dependent analyses, including transient response, step response, input impedance, and frequency-dependent noise spectra, to compare a cascaded double output configuration with a pre-current amplifier design. The results indicate a trade-off between dynamic range and linearity, with the pre-current amplifier demonstrating a higher dynamic range but lower linearity compared to the cascaded configuration. Additionally, the current amplifier configuration exhibited advantages in power consumption …