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Parents’ Perceptions Of The Influence Of Interpersonal Trauma On Children’S Academic Achievement In Low Socioeconomic Families During The Covid-19 Pandemic, Brandi Walker Aug 2025

Parents’ Perceptions Of The Influence Of Interpersonal Trauma On Children’S Academic Achievement In Low Socioeconomic Families During The Covid-19 Pandemic, Brandi Walker

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic intensified the challenges faced by families from low socioeconomic (SES) backgrounds regarding their children’s academic development. Students during this time experienced disruptions in their academic development, further hindering their educational progress. The purpose of this qualitative phenomenological study was to explore parents’ perceptions of how interpersonal trauma and SES challenges impacted their elementary-age children’s academic achievement during the pandemic. Bronfenbrenner’s ecological systems theory served as the theoretical foundation, offering a framework to understand how environmental factors shaped children’s experiences and academic development. Data were gathered through semistructured interviews with eight parents from low-SES backgrounds. Content analysis of …


The Meaning Of Academic Achievement For Fathers Of African American At-Risk Urban Female Youth, Shurise Telesford Aug 2025

The Meaning Of Academic Achievement For Fathers Of African American At-Risk Urban Female Youth, Shurise Telesford

Walden Dissertations and Doctoral Studies

Family dynamics, parenting styles, and the impact of parental involvement on children have long been studied, with much of the focus traditionally placed on the mother-child relationship. This study shifted that focus to explore the perceptions of African American fathers of at-risk female youth regarding academic achievement. Using a generic qualitative approach and guided by Freire’s Pedagogy of the Oppressed, a theory emphasizing how the marginalized learn through critical awareness and collaboration, I sought to understand how these fathers view their daughters’ educational experiences and barriers to success. Data were collected through semi-structured interviews with seven fathers living in urban …


Gendered Challenges In The Chinese Workplace : Examining Maternity Leave And Discrimination Against Working Mothers In Shenzhen, Tianyang Wen Aug 2025

Gendered Challenges In The Chinese Workplace : Examining Maternity Leave And Discrimination Against Working Mothers In Shenzhen, Tianyang Wen

Lingnan Theses (Doctoral degree)

Under the background that labor competition and the society progress become more in-tense, the dilemma of motherhood faced by working women has become increasingly prominent. This dissertation aims to explore gender challenges in the Chinese workplace, in particular the maternity leave system and its impact on discrimination against working mothers. Taking Shenzhen as an example, this study adopts qualitative research methods and systematically examines the challenges faced by working mothers in terms of maternity leave and employment discrimination through in-depth interviews with ten working mothers, seven human resource managers, three corporate employers and three in-depth interviewers. The study found that: …


Antidepressant Medication Nonadherence In Adult Patients With A Major Depressive Disorder, Sandrine Djou Kaze Aug 2025

Antidepressant Medication Nonadherence In Adult Patients With A Major Depressive Disorder, Sandrine Djou Kaze

Walden Dissertations and Doctoral Studies

The chosen approach for the Doctor of Nursing Practice (DNP) project was a clinical practice guideline (CPG) on interventions to improve antidepressant medication adherence in adults diagnosed with depression in an outpatient setting. The consequences of medication nonadherence in patients with depression are devastating for individuals and the healthcare system. Therefore, addressing it within nursing practice is essential to improve treatment efficacy and patient outcomes. The practice question related to the DNP project was to determine whether the CPG could improve antidepressant medication compliance in adults diagnosed with a depressive disorder in an outpatient setting. I aimed to develop a …


Ecological Drivers And Temporal Dynamics Of Daphnia In A Diverse Environmental And Spatial Landscape, Crysta A. Gantz Aug 2025

Ecological Drivers And Temporal Dynamics Of Daphnia In A Diverse Environmental And Spatial Landscape, Crysta A. Gantz

Dissertations and Theses

In the modern era, commonly referred to as the Anthropocene, human-caused changes to the environment are prevalent and complex. The study of impacts to biodiversity and ecosystem functioning requires multi-faceted approaches that encompass scales of organization from genes to ecosystems. It is often difficult to tease apart whether species responses to environmental change are due to phenotypic plasticity or genotypic variation. Therefore, it is important to try to understand where variation originated, that is, to link a phenotypic response to a genetic change or to gauge whether the response is from the environment. In addition, neutral genetic variation arising from …


Targeted Proteomic Analysis Identifies Acvrl1 As A Marker Of Cerebral Edema In Aneurysmal Subarachnoid Hemorrhage, Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi Aug 2025

Targeted Proteomic Analysis Identifies Acvrl1 As A Marker Of Cerebral Edema In Aneurysmal Subarachnoid Hemorrhage, Bosco Seong Kyu Yang, Lena O'Keefe, Sarah Hinds, Hua Chen, Athziry Paz, Jude Savarraj, Han-Gil Jeong, Moon-Ku Han, Aaron Gusdon, Xuefang Sophie Ren, Spiros Blackburn, Huimahn Alex Choi

Faculty, Staff and Student Publications

Cerebral edema (CE) is a major component of early brain injury from aneurysmal subarachnoid hemorrhage (SAH). Despite the utility of blood-based protein markers, biomarkers targeting cerebral edema have yet to be developed. We performed a targeted proteomic search analyzing 141 proteins in plasma samples taken from 80 adult patients within 48 hours after aneurysmal rupture to identify plasma biomarkers of cerebral edema. The protein expression profiles were analyzed for associations with a higher level of the subarachnoid hemorrhage early brain edema score measured in admission computed tomography scans. Five differentially expressed proteins-brorin, ectodysplasin A2 receptor, layilin, scavenger receptor class A …


First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio Aug 2025

First-Line Pd-1 +/- Ctla-4 Blockade In Patients With Deficient Mismatch Repair And/Or Microsatellite Instability-High Metastatic Colorectal Cancer, Vincenzo Nasca, Gabriele Tinè, Julien Taieb, Sara Lonardi, Ben Boursi, Ofer Margalit, Lisa Salvatore, Romain Cohen, Javier Ros, Margherita Ambrosini, Koen Zwart, Jeanine Roodhart, Priya Jayachandran, Michael J Overman, Maria Elena Elez, Chiara Cremolini, David Tougeron, Miriam Koopman, Thierry André, Rosalba Miceli, Filippo Pietrantonio

Faculty, Staff and Student Publications

Background: Patients with deficient mismatch repair (dMMR) and/or microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) show marked sensitivity to immune checkpoint inhibitors (ICIs). Dual PD-1/CTLA-4 blockade with nivolumab and ipilimumab showed superior progression-free survival (PFS) over chemotherapy and anti-PD-1 monotherapy, but data on treatment-naïve patients is not available yet.

Methods: This international multicenter study included patients with dMMR/MSI-H mCRC receiving either chemotherapy with or without biologics, or anti-PD-1 monotherapy, or dual PD-1/CTLA-4 blockade as a first-line treatment. Data were adjusted using inverse probability of treatment weighting (IPTW) to account for baseline imbalances. IPTW-adjusted survival and subgroup analyses were conducted.

Results: …


The Promise And Peril Of Comparing Fluorescence Lifetime In Biology Revealed By Simulations, Pingchuan Ma, Peter Chen, Scott Sternson, Yao Chen Aug 2025

The Promise And Peril Of Comparing Fluorescence Lifetime In Biology Revealed By Simulations, Pingchuan Ma, Peter Chen, Scott Sternson, Yao Chen

2020-Current year OA Pubs

Signaling dynamics are crucial in biological systems, and biosensor-based real-time imaging has revolutionized their analysis. Fluorescence lifetime imaging microscopy (FLIM) excels over the widely used fluorescence intensity imaging by allowing the measurement of absolute signal levels independent of sensor concentration. This capability enables the comparison of signaling dynamics across different animals, body regions, and timeframes. However, FLIM's advantage can be compromised by factors like autofluorescence in biological experiments. To address this, we introduce FLiSimBA, a flexible computational framework for realistic


Multi-Ancestral Genome-Wide Association Study Of Clinically Defined Nicotine Dependence Reveals Strong Genetic Correlations With Other Substance Use Disorders And Health-Related Traits, Emma C Johnson, Jared V Balbona, Alexander S Hatoum, David A A Baranger, Louis Fox, Paul W Jeffries, Laura J Bierut, Andrew C Heath, Pamela A Madden, Elliot C Nelson, Arpana Agrawal, Et Al. Aug 2025

Multi-Ancestral Genome-Wide Association Study Of Clinically Defined Nicotine Dependence Reveals Strong Genetic Correlations With Other Substance Use Disorders And Health-Related Traits, Emma C Johnson, Jared V Balbona, Alexander S Hatoum, David A A Baranger, Louis Fox, Paul W Jeffries, Laura J Bierut, Andrew C Heath, Pamela A Madden, Elliot C Nelson, Arpana Agrawal, Et Al.

2020-Current year OA Pubs

BACKGROUND: Genetic research on nicotine dependence has utilized multiple assessments that are in weak agreement.

METHODS: We conducted a genome-wide association study (GWAS) of nicotine dependence defined using the Diagnostic and Statistical Manual of Mental Disorders (DSM-NicDep) in 61,861 individuals (47,884 of European ancestry [EUR], 10,231 of African ancestry, and 3,746 of East Asian ancestry) and compared the results to other nicotine-related phenotypes.

RESULTS: We replicated the well-known association at the

CONCLUSIONS: Our results suggest that combining the wide availability of diagnostic EHR data with nuanced criterion-level analyses of DSM tobacco use disorder may produce new insights into the genetics …


Strategies To Develop Professional Identity Of Teachers From Non-Education Faculty: A Case Study, Klara Tyas Sulistyawati, Paulus Kuswandono Aug 2025

Strategies To Develop Professional Identity Of Teachers From Non-Education Faculty: A Case Study, Klara Tyas Sulistyawati, Paulus Kuswandono

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Nowadays, teachers do not always graduate from the education faculty. This phenomenon attracts researchers to conduct a study about the strategies to develop teacher professional identity, specifically for teachers from non-education faculty. In this study, the researchers implemented a case study method. To collect the data, the researchers distributed a closed-ended questionnaire to six teachers from the non-education faculty and did interview sessions. The researchers concluded the three major findings, namely (1) perceiving oneself, (2) gaining valuable insight through the teacher community, and (3) doing reflection on previous teaching experiences.


Enhancing Student Engagement And Cognitive Development Through Game-Based Learning (Gbl), Kusuma Rani, Putri Dwi Lestari, Saenab Ka-Lupae Aug 2025

Enhancing Student Engagement And Cognitive Development Through Game-Based Learning (Gbl), Kusuma Rani, Putri Dwi Lestari, Saenab Ka-Lupae

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Elementary school students are classified as playing-age children, they like to do activities while playing. This research aims to determine the influence of the Game-Based Learning (GBL) learning model on students' cognitive activities and abilities. This type of research is quasi-experimental, one-group pre-test and post-test design. The population of this study were Madrasah Ibtidaiyah students at Darussalam Seuksa School, Thepa, Southern Thailand. The research sample for grade 5 students was 28 students. Student activity is measured using an observation sheet with indicators measured using a 1-5 Likert scale. Cognitive abilities are measured by tests. The results of data analysis showed …


Pembelajaran Berbasis Proyek Dalam Pembelajaran Ilmu Pengetahuan Alam Untuk Meningkatkan Hasil Belajar Siswa, Agustinus Tanggu Daga, Matias Hota Heli, Petrus Lende Aug 2025

Pembelajaran Berbasis Proyek Dalam Pembelajaran Ilmu Pengetahuan Alam Untuk Meningkatkan Hasil Belajar Siswa, Agustinus Tanggu Daga, Matias Hota Heli, Petrus Lende

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penerapan Ilmu Pengetahuan Alam di sekolah dasar sebagai salah satu mata pelajaran mendukung pelaksanaan pendidikan abad 21. Masalah yang sering ditemui adalah pengetahuan yang kirang pada siswa tentang esensi keilmuan Ilmu Pengetahuan Alam yang berdampak pada kinerja, baik dalam proses pembelajaran maupun dalam hasil belajar. Penelitian ini mengkaji secara ilmiah dampak terhadap hasil belajar dalam pembelajaran berbasis proyek (PjBL). Untuk itu diambil 18 siswa kelas V sebagai subyek penelitian. Penelitian ini menggunakan pendekatan kuantitatif dan metode kuasi eksperimen. Tes hasil belajar digunakan sebagai instrument pengumpulan data yang diterapkan sebelum dan sesudah intervensi. Analisis data mencakup beberapa pendekatan yaitu analisis deskriptif, …


Synthesis And Characterization Of Near-Infrared Fluorescent Dye Cy7-2 For Targeted Cancer Imaging, Eleanor Yerkin Aug 2025

Synthesis And Characterization Of Near-Infrared Fluorescent Dye Cy7-2 For Targeted Cancer Imaging, Eleanor Yerkin

Summer Research Showcase

The growing demand for real-time, precise, cancer diagnostics and treatment has driven the development of targeted near-infrared (NIR) fluorescent biosensors. Traditional visible-range fluorophores, such as Boron-dipyrromethene (BODIPY) dyes are well-known for their high quantum yields, photostability, biocompatibility, and sharp absorption and emission peaks, making them widely used in fluorescence imaging (Nisar and Sui). However, Cyanine dyes offer some advantages over visible-range dyes, such as deeper tissue penetration due to their near-infrared (NIR) absorption and emission, significantly reduced background autofluorescence, and improved signal-to- noise ratios in vivo (Zhang et al.). This project explores the synthesis and characterization of the NIR fluorescent …


Problematic Ideas For A Problematic Group: Untangling Common Depictions Of Transgender Characters In Young Adult Literature, Asiyah Noujdi Aug 2025

Problematic Ideas For A Problematic Group: Untangling Common Depictions Of Transgender Characters In Young Adult Literature, Asiyah Noujdi

Summer Research Showcase

The need and desire for diverse perspectives within young adult (YA) literature led to a boom in the amount of stories featuring trans people at the start of the 21st century and has continued to this day. However these perspectives have not all been positive with earlier books written featuring viewpoints that would be seen by a trans individual as not reflective of their lived experiences. This project aims to compare the depictions of trans people in trans YA from the start of the 21st century up to the present day. The perspectives used within this project will be from …


Penerapan Model Pembelajaran Kooperatif Tipe Talking Stick Untuk Meningkatkan Hasil Belajar Siswa Pada Pelajaran Ipas, Yusdin Bin M. Gagaramusu, Wildani Wildani, Rizal Rizal, Sisriawan Lapasere Aug 2025

Penerapan Model Pembelajaran Kooperatif Tipe Talking Stick Untuk Meningkatkan Hasil Belajar Siswa Pada Pelajaran Ipas, Yusdin Bin M. Gagaramusu, Wildani Wildani, Rizal Rizal, Sisriawan Lapasere

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Penelitian ini bertujuan untuk memberikan wawasan mengenai penerapan model pembelajaran kooperatif tipe talking stick sebagai upaya meningkatkan hasil belajar siswa pada mata pelajaran IPAS kelas IV SD Negeri 9 Mamboro. Jenis penelitian yang dilakukan adalah Penelitian Tindakan Kelas (Classroom Action Research) yang dikembangkan oleh Kemmis dan Mc Taggart yang terdiri dari empat tahapan, yaitu: (1) Perencanaan, (2) Tindakan, (3) Observasi, dan (4) Refleksi. Penelitian ini dilaksanakan di SD Negeri 9 Mamboro, pada tahun ajaran 2024/2025 dengan subjek penelitian berjumlah 23 siswa kelas IV. Dalam penelitian ini, teknik pengumpulan data meliputi tes dan non-tes. Hasil penelitian menunjukkan bahwa selama proses pembelajaran …


U.S News & World Report 2025 Graduate Program Rankings, Unlv & Unr, Dre Boyd-Weatherly, Caitlin J. Saladino, William E. Brown Jr. Aug 2025

U.S News & World Report 2025 Graduate Program Rankings, Unlv & Unr, Dre Boyd-Weatherly, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet presents 2025 graduate program rankings for the University of Nevada, Las Vegas (UNLV) and for the University of Nevada, Reno (UNR) based on the data published in spring 2025 by U.S. News & World Report. The graduate program categories reported include business, education, engineering, fine arts, law, medicine and health care, sciences and mathematics, and social sciences and humanities.


Innocence Stolen, Echo K. Yerke Aug 2025

Innocence Stolen, Echo K. Yerke

Master of Arts in Human Services

Childhood sexual abuse (CSA) is a negative societal problem. It isn’t an easy problem to solve; there is a lot of secrecy involved. The literature review will look at early interventions and prevention. The paper tries to show how it would benefit society if there were more money dedicated to programs to prevent childhood sexual abuse. The paper shows the negative outcomes that happen to the victims and possibly their future generations. The paper will look at the relationship between childhood sexual abuse (CSA) and suicide. It also looks at the mental health struggles that victims go through. It also …


Beyond The Bottle: The Lifelong Consequences Of Fetal Alcohol Spectrum Disroder, Victoria M. Van Curen Ms. Aug 2025

Beyond The Bottle: The Lifelong Consequences Of Fetal Alcohol Spectrum Disroder, Victoria M. Van Curen Ms.

Master of Arts in Human Services

With increasing numbers of Fetal Alcohol Spectrum Disorder, the focus is on FASD and the impact it has on mothers’, their unborn child, and the consequences that will lead to long-lasting effects. Once women find out that they are expecting, they stop drinking alcohol, but there is still statistic that shows about 8% of women reported that they continue to consume alcohol during their pregnancy. The paper will also include multiple real-life examples of studies that have been conducted on individuals with FASD. With studies focusing on individuals with FASD, it will also include different populations with FASD, and the …


Unmasking The Shadows: A Comprehensive Exploration Of Serial Killers, Erica D. Lewis Aug 2025

Unmasking The Shadows: A Comprehensive Exploration Of Serial Killers, Erica D. Lewis

Master of Arts in Human Services

Using a mixed-methods approach that combines quantitative literature review and qualitative case study analysis, this capstone investigates the developmental pathways of serial killers. The study investigates a variety of biological, psychological, and sociological elements—such as genetic predispositions, neurological disorders, childhood traumas, and environmental stressors—interact to shape serial killers. The study offers a multidisciplinary perspective, grounded in criminological models such as routine activity and labeling theories, sociological frameworks such as social disorganization and strain theory, and psychological theories such as psychopathy and attachment theory. Theoretical findings are contextualized through case studies of notorious serial killers like Ted Bundy, Jeffrey Dahmer, and …


Re-Engaging Driver Attention Using Chatgpt: A Multimodal Study On Stress Impact And Driving Performance, Alaa Zaki Elfiqi Aug 2025

Re-Engaging Driver Attention Using Chatgpt: A Multimodal Study On Stress Impact And Driving Performance, Alaa Zaki Elfiqi

Theses and Dissertations

Driving is considered a complex task that requires continuous focus and attention from the driver. Driving performance can also be impacted by changes in the driver’s stress level. However, limited research explores methods to address this challenge. With the current advances in Large Language Models (LLMs) and their ability to engage in human-like interaction, this study investigates the potential of using ChatGPT, designed to speak Egyptian Arabic, in re-engaging driver attention under different driving scenarios for low-stress and high-stress conditions within a virtual reality (VR) environment driving simulator. Drivers were asked to follow a leading car into two scenarios with …


Exploring Neuropsychiatric Manifestations Of Vitamin B Complex Deficiencies, Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan Salloum, Salim Kanaan, Bharathi Gadad, João Paulo Lima Daher Aug 2025

Exploring Neuropsychiatric Manifestations Of Vitamin B Complex Deficiencies, Anamaria Han, Leandro Almeida, Nikhilesh Anand, Ihsan Salloum, Salim Kanaan, Bharathi Gadad, João Paulo Lima Daher

School of Medicine Publications

B complex vitamins, a group of eight water-soluble vitamins, play interconnected roles in maintaining nervous system health. Thiamine (B1), riboflavin (B2), and niacin (B3) are essential as co-enzymes in numerous metabolic reactions related to energy production. Thiamine is involved in the Krebs cycle, riboflavin in the electron transport chain, and niacin plays a key role in both glycolysis and the Krebs cycle. These metabolic processes are vital for sustaining the integrity of the nervous system, as the energy produced is critical for the functioning of nerve cells. Deficiencies in these vitamins can lead to significant neurological and psychiatric conditions, including …


Efficient Decontamination Of Organophosphate-Based Pesticides And Nerve Agent Simulants Mediated By N-Containing Nucleophiles, Emmanuel Kingsley Darkwah, Puspa Aryal, Saidulu Todeti, Jared Kenik, Samuel Insall, V. Prakash Reddy, Chariklia Sotiriou-Leventis Aug 2025

Efficient Decontamination Of Organophosphate-Based Pesticides And Nerve Agent Simulants Mediated By N-Containing Nucleophiles, Emmanuel Kingsley Darkwah, Puspa Aryal, Saidulu Todeti, Jared Kenik, Samuel Insall, V. Prakash Reddy, Chariklia Sotiriou-Leventis

Chemistry Faculty Research & Creative Works

There is a growing interest in developing safer and more effective decontaminating agents for organophosphate-based pesticides and nerve agents. In this study, we present an effective method for the nonaqueous decontamination of these compounds using small-molecule-based decontaminating agents under ambient conditions. Our approach utilizes aryl and heteroaryl carboxaldehyde hydrazones and hydrazides to effectively hydrolyze nerve agent simulants into their nontoxic degradation products. The effectiveness of this method was evaluated using a range of nerve agent simulants, including dimethyl 4-nitrophenyl phosphate (DMNP), dimethyl methyl phosphonate (DMMP), and triphenyl phosphate (TPhP). In the presence of the heteroaryl hydrazone, the rate of hydrolysis …


Enhanced Meropenem Activity And Stability Following Load In Polyvinyl Alcohol Nanofiber Scaffolds With Sitagliptin As Quorum Sensing Inhibitor On Pseudomonas Aeruginosa, Samar A. Salim, Abdelrhman Mohsen, Mohamed Emara, Taghrid Elmahdy Aug 2025

Enhanced Meropenem Activity And Stability Following Load In Polyvinyl Alcohol Nanofiber Scaffolds With Sitagliptin As Quorum Sensing Inhibitor On Pseudomonas Aeruginosa, Samar A. Salim, Abdelrhman Mohsen, Mohamed Emara, Taghrid Elmahdy

Nanotechnology Research Centre

Background The increasing resistance of bacteria to conventional antibiotics poses a significant health challenge. Innovative strategies, such as combining antibiotics with agents like quorum sensing inhibitors (QSIs), have been developed to combat this issue. QSIs enhance antibiotic efficacy without inhibiting bacterial growth, minimizing the risk of resistance. Aims Evaluate the combined effect of Sitagliptin (STG) as a QSI with Meropenem (MER), fabricate drug-loaded Polyvinyl Alcohol (PVA) nanofibers, and investigate their antimicrobial activity against standard Pseudomonas aeruginosa (PAO1) and carbapenem-resistant P. aeruginosa (CRPA). Methods The combinatorial effect was assessed using a checkerboard assay. PVA/STG, PVA/MER, and PVA/STG/ MER nanofibers were fabricated …


Platelet Protease-Activated Receptor 4 Genotype And Response To Aspirin In Pregnancy, Rupsa C. Boelig, James V. Michael, Antonios Tawk, Tingting Zhan, Joanna S. Y. Chan, Walter K. Kraft, Steven E. Mckenzie Aug 2025

Platelet Protease-Activated Receptor 4 Genotype And Response To Aspirin In Pregnancy, Rupsa C. Boelig, James V. Michael, Antonios Tawk, Tingting Zhan, Joanna S. Y. Chan, Walter K. Kraft, Steven E. Mckenzie

Department of Medicine Faculty Papers

The platelet protease-activated receptor 4 (PAR4) threonine 120 (Thr120) allele is an activating allele associated with reduced aspirin response in vitro. Aspirin is recommended in high-risk pregnancies to prevent preeclampsia and preterm birth. We evaluated the impact of PAR4 genotype on aspirin response in pregnancy, as measured by platelet function assay 100 (PFA-100) epinephrine closure time, and perinatal outcomes. We conducted a prospective cohort study of high-risk pregnant patients who took 81-mg aspirin daily. PFA-100 was assessed at baseline, 2 to 4 weeks after aspirin initiation (follow-up 1), and 28 to 32 weeks’ gestation (follow-up 2). Primary outcome was difference …


Screening And Variable Selection For Analyzing Binary Outcome With Rare Events And High-Dimensional Predictors, Mohammad Nahian Ferdous Abrar Aug 2025

Screening And Variable Selection For Analyzing Binary Outcome With Rare Events And High-Dimensional Predictors, Mohammad Nahian Ferdous Abrar

Electronic Theses and Dissertations Archive

Binary outcomes with rare events (event rate less than 5%) present significant analytical challenges, particularly in high-dimensional settings such as epigenome-wide association studies (EWAS) involving DNA methylation data. Traditional logistic regressions are often inadequate under these conditions, suffering from bias, high variance, and diminished power when the event rate is low and the number of predictors exceeds the sample size (p >> n). To address these limitations, we developed a series of novel methods that enhance sensitivity and accuracy in identifying biologically meaningful biomarkers while accounting for both event rarity and high dimensionality. We first introduce two innovative screening approaches. The …


Emotional Development In Infancy, Claire Sanford, Samantha Gott Aug 2025

Emotional Development In Infancy, Claire Sanford, Samantha Gott

Florida Atlantic Undergraduate Research Journal

Developmental science has documented that infants’ emotional reactions are shaped by individual dispositions and their environment. This study investigated fear responses along with patterns of brain development in infants 6 to 10 months. Nine infant-mother dyads participated, with each infant observed twice (18 visits). An electroencephalogram (EEG) was used to analyze brain activity during resting-state and fear-eliciting conditions. Infant fear vocalizations were evaluated and coded during two conditions, i.e., an unfamiliar object (an electronic toy-spider), and an unfamiliar adult approaching. Results indicated infants’ fear vocalizations were stimuli-specific, with more fear expressed towards approaching strangers than the novel object. Findings also …


Impacts Of Climate Change On Vertical Migration Of Zooplankton Species, Camila Rimoldi Ibañez Aug 2025

Impacts Of Climate Change On Vertical Migration Of Zooplankton Species, Camila Rimoldi Ibañez

Florida Atlantic Undergraduate Research Journal

Vertical migration in marine and freshwater environments stands as one of Earth’s largest daily animal movements concerning biomass. It serves as a crucial life pump, shaping phytoplankton grazing patterns, facilitating nutrient transport through the water column, and providing vital sustenance for deep-water organisms lacking access to surface phytoplankton. Despite enduring millennia of climatic shifts, contemporary anthropogenic climate change surpasses historical rates of change, posing unprecedented challenges. Climate-induced phenomena increasingly affect various species, including vertical migrators. This paper delves into Diel Vertical Migration’s ecological significance and anticipates detrimental effects of climate change on individual animals’ physiology and migration patterns. Foremost, rising …


The Relationship Between Self-Reported And Observer-Rated Maternal Anxiety During Mother-Infant Interactions, Annalisa Tran, Jacqueline Hammack Aug 2025

The Relationship Between Self-Reported And Observer-Rated Maternal Anxiety During Mother-Infant Interactions, Annalisa Tran, Jacqueline Hammack

Florida Atlantic Undergraduate Research Journal

Research pertaining to maternal anxiety and mother-infant interactions is a rapidly growing field. The purpose of this study is to investigate the relationship between self-reported maternal anxiety ratings and observer-rated maternal anxiety scores. Thirty-nine motherinfant dyads participated in a four-minute free-play session via Zoom. The Parent Anxiety measure from the Coding Interactive Behavior scale was used to measure observed maternal anxiety. The General Anxiety Disorder-7 scale was used to measure self-reported maternal anxiety. No significant association was found between self-reported maternal anxiety and observed maternal anxiety. An exploratory analysis was conducted to compare self-reported maternal anxiety and observed maternal sensitivity. …


Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin Aug 2025

Use Of A Novel Plant Essential Oil-Based Insecticide For Insect Control In Household Gardens And Lawns, Mia Michnik, Alysa Suissa, Liah Brussolo Cremona, Annalise Wellman, Nicholas Nifakos, Alexander Spanoudis, John M. Harlin

Florida Atlantic Undergraduate Research Journal

Insecticide use has increased as population and agricultural demand for crops grows. Commercial insecticides contain active ingredients that are often harmful to humans and the environment. A viable alternative to this concern is developing and using insecticides with low toxicity and minimum risk to the environment. In this study, we sought to empirically assess the effectiveness of an insecticide based entirely on plant essential oil active ingredients, which contain complex secondary metabolites. Our results show that a concoction of several plant essential oils was effective in killing a wide range of household garden insect species and bedbugs, encompassing five orders …


Biographies, Editorial Team Aug 2025

Biographies, Editorial Team

Florida Atlantic Undergraduate Research Journal

No abstract provided.