Digital Commons Network^™

Characterization Of The Electronic Structure Of Metal–Organic Framework Mil-125 And Its Derivatives Using Soft X-Ray Spectroscopies, Jennifer Alexia Napoles

UNLV Theses, Dissertations, Professional Papers, and Capstones

Metal–organic frameworks (MOFs) are highly porous, three-dimensional networks composed of coordinated metal clusters and organic ligand subunits. While tens of thousands of MOFs have been synthesized, the Ti(IV)-based MOF MIL-125 has garnered scientific interest due to the observed changes to its optical and photocatalytic properties upon chemical modification. For example, upon UV irradiation in the presence of an alcohol, MIL-125 undergoes a photochromic color change to a photodoped state that has been associated with the storage of charge in the form of Ti(III) sites. Another example is exemplified by the amine group functionalization of the 1,4-benzenedicarboxylate (BDC) linker of MIL-125 …

Design And Development Of Biomimetic Hydrogel Interfaces For Enhanced Bioelectrical Signal Acquisition, Daniela Nikoloska

UNLV Theses, Dissertations, Professional Papers, and Capstones

Every second, human skin processes over one million sensory signals while maintaining properties such as electrical conductivity, mechanical adaptability, and regenerative capability that surpass all synthetic materials. Contemporary bioelectronic devices prove inadequate when contacting skin surfaces due to poor adhesion and electrical contact issues that prevent effective sensing. Despite advancements in wearable and bioelectronic technologies, current devices face major drawbacks when interfacing with human skin, particularly in maintaining firm adhesion, conformability, and low-noise electrical signal acquisition.

This research focuses on the development of a biomimetic hydrogel-based interface for bioelectronic sensing. Specifically, a hybrid hydrogel system composed of polydopamine (PDA)- doped …

Modeling The Mojave: A Multiphase, Mixed Methods Phenomenological Investigation Of Novice Understanding Of A Complex Ecological System, Nicole Juliana Thomas

UNLV Theses, Dissertations, Professional Papers, and Capstones

This research explores early college science majors’ conceptions of the Mojave Desert ecosystem as a complex system. A multi-level, explanatory sequential mixed methods design was employed to study college science majors’ understanding of the Mojave Desert ecosystem to better inform science pedagogy. The first level, the quantitative phase of the study, consisted of developing a mathematical representation of twelve ecosystem variables present within the Mojave Desert. The second level, the qualitative phase of the study, consisted of phenomenological semi-structured interviews with 23 early college science majors. The findings of this research suggest that the Mojave Desert operates as a complex, …

Spinach (Spinacia Oleracea L) Flavonoids Are Hydrolyzed During Digestion And Their Bioaccessibility Is Under Stronger Genetic Control Than Raw Material Content, Michael P Dzakovich, Alvin L Tak, Elaine A Le, Rachel P Dang, Benjamin W Redan, Geoffrey A Dubrow

Children’s Nutrition Research Center Staff Publications

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Profit & Loss: A Narrative Inquiry Into The Salience Of The Black Male Experience In Top-Tier U.S. Mba Programs, Craig Woodward

Seton Hall University Dissertations and Theses (ETDs)

This study aimed to explore the educational, cultural, and personal challenges faced by Black males in MBA programs and to identify factors that aid their persistence in completing their degrees. The research design employed a qualitative approach to narrative inquiry as its methodology, using one-on-one semi-structured interviews. The study used resilience theory as its theoretical framework, approaching it from both an academic and psychological perspective. Respondents were recruited from the top 50 MBA programs in the United States according to the 2023 edition of U.S News and World Report (2024). There were a total of 15 African American respondents who …

Investigation Of Mono-Allelic Rack1 Deletion Effects On Cell Growth And Pkc Mrna Expression, Ashen Quiambao

Seton Hall University Dissertations and Theses (ETDs)

The µ-opioid receptor is a primary target of clinically used opioids, and RACK1 regulates its transcription by physically interacting with MOR transcription regulator PCBP1 in the cytosol to prevent its nucleus translocation. Two mono-allelic RACK1 knockout cell lines named RACKA and RACKB were generated by the CRISPR-Cas9 technique using WT NMB neuroblastoma cells. As RACK1 also contains a PKC-binding domain, this study aims to evaluate the impacts of mono-allelic deletion on cell growth rates and PKC isoform expression. Although a slight decreased tendency of growth rate in RACKA and RACKB cells was observed when compared to that of WT NMB …

Socially Interfering Sexual Behaviors In Autistic Adolescents And Treatments As Reported By Behavior Analysts, Steven Pai

Seton Hall University Dissertations and Theses (ETDs)

Caregivers often express concern regarding socially interfering sexual behaviors (SISB) in autistic adolescents, yet recent literature offers limited updates on this topic. Existing survey studies have primarily relied on parent, caregiver, or educator reports, with little focus from the perspective of healthcare professionals. To address this gap, the present study surveyed Board Certified Behavior Analysts (BCBA) about the SISB they encounter, commonly utilized interventions employed, and their perceived effectiveness. Of 120 respondents, 74 qualified BCBAs provided data on behaviors such as socially interfering comments, public masturbation, touching others, and public disrobing. Public arousal, verbal remarks/comments, and sexualized gestures were the …

Clerodendrum Kelli (Lamiaceae), A New Species From Carranglan, Nueva Ecija, Philippines, And Lectotypification Of Clerodendrum Mindorense, David Justin R. Ples, Jacek Patykowski, John Charles A. Altomonte, Adriene B. Tobias, Rene Alfred Anton Bustamante

Biology Faculty Publications

Clerodendrum kelli (Lamiaceae), a new species from the montane forests of Carranglan, Nueva Ecija, Philippines, is described and illustrated. The species shares morphological features with Clerodendrum quadriloculare and C. mindorense, but differs in inflorescence structure, corolla tube length, and calyx shape and color. A lectotype for C. mindorense is also designated. Preliminary conservation assessment places C. kelli in the Critically Endangered category (CR B1ab(iii)+2ab(iii)). This study contributes to Philippine plant biodiversity knowledge and informs conservation strategies.

Current Insight Into Ldlr And Pcsk9 Genetic Variants: Investigating Genetic Keys To Cholesterol In A Cohort Of Stroke Patients From Yogyakarta, Indonesia, Loury Priskila, Lenggana Relung Atmadi, Arya Taksya Bagaskara, Andreas Mercyan Anggitama

Makara Journal of Health Research

Background: Stroke is the second leading cause of mortality worldwide. In Yogyakarta, Indonesia, the incidence of stroke (14%) is higher than the national average. We therefore investigated the roles of LDLR rs688 (C/T) and PCSK9 rs562565 (A/G) polymorphisms in familial hypercholesterolemia as predictors of first-time ischemic stroke.

Methods: In this case-control study, 119 first-time ischemic stroke patients were divided into dyslipidemia (N = 71) and non-dyslipidemia groups (N = 48). The DNA of the nucleotide polymorphisms LDLR rs688 (C/T) and PCSK9 rs562556 (A/G) was extracted and analyzed using the PCR-RFLP method, and statistical analyses were performed to evaluate …

Moving Toward Healthy Ageing: The Role Of Physical Activity In Cognitive Function And Self-Esteem Among Older Adults In Türkiye, Canan Birimoglu Okuyan, Müjde Kerkez

Makara Journal of Health Research

Background: This study aimed to evaluate the relationship between religious attitudes and breastfeeding attitudes and the effect of this relationship on breastfeeding practices.

Methods: A cross-sectional study was conducted with 251 older adults. Data were collected using the International Physical Activity Questionnaire, the Standardized Mini-Mental State Examination, and the Rosenberg Self-Esteem Scale. Spearman’s correlation and chi-square tests were employed for statistical analysis.

Results: Physical activity levels were positively correlated with both cognitive function (r = 0.546, p < 0.001) and self-esteem (r = 0.168, p < 0.05). No significant association was observed between cognitive function and self-esteem. Physical inactivity, cognitive decline, and low self-esteem were more prevalent among women, participants with lower educational attainment, those with chronic diseases, and individuals engaged in polypharmacy.

Conclusions: The findings emphasize the importance of integrating physical activity promotion into national healthy ageing policies, particularly in Mediterranean contexts such …

Understanding Parental Perceptions Of Truancy In Connecticut Youth: Identifying Risks And Prevention Strategies, Samantha Villa

Honors Theses

This research investigates Connecticut parents' perspectives on effective strategies for addressing truancy. By examining stakeholder attitudes and beliefs, the study aimed to understand the relationship between perceptions of responsibility for truancy prevention and support for punitive versus non-punitive intervention approaches. In light of the COVID-19 pandemic's impact on truancy rates, current legislation and interventions have proven inadequate. This study assessed Connecticut adults' recommendations for truancy policy reforms and explored the potential for community-based interventions to enhance family engagement and reduce reliance on court involvement and punitive sanctions. IBM SPSS was used to analyze an existing dataset from the Tow Youth …

Effects Of Proactive Interference On Adults With Adhd: A Sex-Based Study, Julia Switzer

Honors Theses

ADHD is a widespread phenomenon that affects individuals in a variety of ways. Many individuals exhibit strong proactive interference, in which past memories interfere with the memorization and recall of new information. One of the ways symptoms differ is through the biological sex of individuals, although differences in proactive interference have not been studied in relation to sex. This study hypothesized that women with ADHD are better at resisting proactive interference than males with ADHD. The study involved a digital activity in which a series of colored shapes was shown to participants, who identified whether the previously displayed shapes or …

Race, Fear Of Falls, Built Environment And Physical Activity In Older Adults With Cancer, Kristen Fessele

General Submissions: Community and Population-based Materials

Motivation for older adults with cancer (OAC) to engage in physical activity (PA) during and after cancer treatment may be limited by many factors. OAC may be affected by persistent symptoms limiting PA capability such as fatigue, pain and dyspnea, or lack safe home or neighborhood spaces to engage in activity. Fear of falling (FOF) is a major concern among OAC and may decrease PA and life-space mobility. To understand how OAC perceptions of cancer treatment, FOF and their local built environment (BE) influence PA behaviors, we partnered with ResearchMatch.org to recruit a sample of 19 people with a history …

Artificial Intelligence: A Double-Edged Sword In Support And Subversion Of The Biological Weapons Convention; Part Two: Implications And Recommendations, Diane Dieuliis, Elise Annett, James Giordano

Strategic Insights

This commentary is Pt. 2 of the "Artificial Intelligence: A Double-Edged Sword in Support and Subversion of the Biological Weapons Convention" series. This piece analyzes how artificial intelligence (AI) interacts with the Biological Weapons Convention (BWC) in both supportive and potentially adversarial ways. The authors explain that AI can strengthen biodefense by improving detection, biosurveillance, and compliance monitoring of biological threats. For example, AI can integrate large datasets to identify anomalies in genomic sequences or global research activity that indicate misuse. However, the same capabilities can be exploited to develop, conceal, and disseminate biological agents, automate laboratory processes that lower …

A Long Non-Coding Rna Leat1 Mediates The Hormone Responsiveness Of Efnb2 During Male Urogenital Development, Deidre Mattiske, Pascal Bernard, Paul E Gradie, Richard R Behringer, Paul A Overbeek, Rachel J O'Neill, Tiffany Phillips, Melanie Stewart, Neil Youngson, Gerard Tarulli, Andrew J Pask

Faculty, Staff and Students Publications

The novel long non-coding RNA (lncRNA) Leat1 is extraordinarily conserved in both its location (syntenic with EfnB2, an essential gene in anogenital patterning) and sequence. Here we show that Leat1 is upregulated following the production of testosterone from the developing testis in mice and interacts with EfnB2, positively regulating its expression. Leat1 expression is suppressed by estrogen, which in turn suppresses the expression of EfnB2. Moreover, the loss of Leat1 leads to reduced EfnB2, resulting in a severe hypospadias phenotype. The human LEAT1 gene is also co-expressed with EFNB2 in the developing human penis, suggesting a conserved function for this …

Studying Causal Inferences For Student Success In Higher Education, Prabesh Shrestha

Theses and Dissertations

Higher education institutions strive to support students in achieving their academic goals through targeted interventions and data-driven strategies. This study analyzed 19 variables, spanning student demographics, enrollment patterns, and institutional interventions, to identify predictors of students completing all enrolled courses in a semester. Using random forest, logistic regression, and bootstrap forest models, we assessed variable importance and derived causal estimates to determine their impact. Results from causal analysis indicate positive effects from session type, term load, referrals, kudos, flags, and scholarships, while negative impacts were associated with location, course delivery method, enrollment status, advisor contact, and registration interval. These findings …

Achieving More Accurate And Interpretable Fraud Detection With Double Machine Learning, Jeremy Andrew Berry

Theses and Dissertations

Fraud detection remains a critical challenge across industries such as insurance, healthcare, finance, and government. Global losses from fraud and financial crime are estimated in the trillions annually, including billions in healthcare and insurance fraud alone. While effective for prediction, traditional machine learning methods often lack causal interpretability and struggle to adapt to evolving fraud tactics. This dissertation investigates the application of Double Machine Learning (DML), an emerging causal inference technique, to enhance both the accuracy and interpretability of fraud analytics. The research compares DML against established causal inference approaches, leveraging a meta-learning framework to evaluate model performance on accuracy, …

Applied Research For Corn Production In Indiana, 2023, Daniel Quinn

Purdue University Press Books

The 2023 edition of Applied Research for Corn Production in Indiana offers accessible, research-based tips for farmers who want to improve corn production practices by using applied field-research trials. Daniel Quinn and the Purdue University Corn Agronomy team reveal practical ways to boost yields, reduce costs, and improve sustainability on the farm. Their findings are derived from applied research trials across the state and relate to important topics such as planting practices, fertilizer use, crop nutrition, cover crops, and new technologies. Applied Research for Corn Production in Indiana distills complex research into clear insights and supplies corn producers with effective …

The Effects Of Educational Materials On Knowledge And Attitudes Toward Psilocybin, Lindsey Elise Wade

Master's Theses

Depression is one of the most prevalent and burdensome mental health conditions worldwide, affecting millions and contributing to over 700,000 deaths by suicide annually. Nearly half of patients with major depressive disorder fail to respond adequately to standard antidepressant treatments such as selective serotonin reuptake inhibitors (SSRIs). Psilocybin-assisted therapy (PAT) has emerged as a promising alternative for treatment-resistant depression (TRD), yet public understanding of this therapy remains limited. The present study examined whether a brief psychoeducational intervention could affect knowledge and attitudes toward PAT among members of the general public in the United States. Participants were randomly assigned to read …

Suicidal Intentions Among Divorced Women In Wasit Province, Khitam Abbas Fadhel, Hassan Aii Ai-Sayed

Alustath Journal for Human and Social Sciences

The current research aims to: Identifying Suicidal Intentions Among Divorced Women Marriage is viewed as a social institution that includes a set of norms regulating the relationship between spouses. The strength of this structure relies on solid foundations such as proper selection and compatibility in social aspects. Marriage imposes on spouses a set of mutual obligations and rights ensuring the continuity of marital life and enabling the family to fulfill its basic functions Despite the psychological, health and social significance marriage, offers to individuals and society, the phenomenon of divorce has been increasingly prevalent in recent times across various communities …

Facts And Hopes Of Chimeric Antigen Receptor-Redirected Nk T Cells, Amy N Courtney, Xin Zhou, Gengwen Tian, Ying Wang, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

Chimeric antigen receptor (CAR)-engineered invariant NK T cells (CAR-NKT) are a novel cell platform for cancer immunotherapy. Unlike conventional T cells, NKTs are characterized by innate antitumor properties, minimal alloreactivity, and a unique ability to modulate the tumor microenvironment. This article provides a comprehensive overview of preclinical and early clinical studies evaluating CAR-NKTs in both autologous and allogeneic clinical settings. We discuss the contributions of CAR signaling domains, cytokine coexpression, and other functional measures that correlate with CAR-NKT persistence, function, and metabolic fitness. We also discuss the critical role of immunocompetent animal models in elucidating the interactions of CAR-NKTs with …

Low-Dimensional Signatures Of Neuronal Activity Associated With Long-Term Operant Conditioning In Aplysia, Sara Vanaki, Nicholas O Gonzalez, Curtis L Neveu, Yuto Momohara, Behnaam Aazhang, John H Byrne

Faculty, Staff and Student Publications

Operant conditioning is a form of learning in which a behavior is reinforced by reward. Operant conditioning has multiple temporal domains, ranging from short-term, lasting a few minutes, to long-term, persisting for at least 24 h. The extent to which short- and long-term operant conditioning memories rely on shared or separate neural mechanisms is poorly understood. Voltage-sensitive dye (VSD) imaging has been used previously to record the activity of a large number of neurons simultaneously in the buccal ganglion to measure changes in neuronal activity during short-term operant conditioning. We examined neuronal activity using VSD 24 h after operant conditioning …

Computational Study Of Cavitation In An Inducer Pump, Jaylen Leonard

UNLV Theses, Dissertations, Professional Papers, and Capstones

Cavitation is ubiquitous in liquid-handling turbomachines. Cavitation bubbles form when the local pressure drops below a fluid’s vapor pressure, and their subsequent collapse causes implosions that generate shockwaves and microjets. These effects lead to fluid instability and structural damage to the blades and casing in turbomachines. This thesis investigates this cavitation phenomenon in turbomachines using Computational Fluid Dynamics (CFD). The cavitation model built in ANSYS Fluent® is first validated in a venturi tube model and then applied to an inducer pump. The geometry of the pump is derived from the Space Shuttle Main Engine (SSME) Low Pressure Oxidizer Pump (LPOP) …

Gaming: An Untapped Resource For Women In Computer Science Careers?, Claudia Quynh Luu

UNLV Theses, Dissertations, Professional Papers, and Capstones

This research focused on women who identify as gamers (i.e., an individual who regularly plays video games) with the goal of better understanding how being a gamer might help or hinder women’s interest in computer science careers. In particular, I examined the connection between interest in computer science careers, gaming, sexual harassment experiences, coping strategies, and allyship for women in gaming using a mixed-methods approach. The sample (N = 166) included women identifying as previous or current gamers. Participants were recruited from a psychology participant pool and gaming communities on Discord. We conducted a series of analyses to examine whether …

First-Principles Insights Into Binary Oxide Systems Under Extreme Pressure, Daniel Schacher

UNLV Theses, Dissertations, Professional Papers, and Capstones

Pressure is powerful tool by which one can manipulate the properties of materials. In this work we utilize pressure to explore binary oxide systems and characterize their structural and electronic properties. The observation of anomalous structural and electronic behavior in the rutile to CaCl2 phase transition in SnO2 led to the prediction that such behavior is inherent to all oxides experiencing such a phase transition sequence.[1] Here, the ultra-wide band gap semiconductor GeO2 is confirmed to exhibit anomalous behavior during the rutile to CaCl2 phase transition. A phase pure rutile GeO2 sample synthesized under high-pressure, high-temperature, conditions is probed using …

Acute And Chronic Effects Of Neuroinflammation On Hippocampus And Anterior Cingulate Cortex Network Dynamics, Lauren A. Crew

UNLV Theses, Dissertations, Professional Papers, and Capstones

Neuroinflammation has emerged as a critical modulator of cognitive function and neural circuit dynamics, yet the distinct contributions of acute and chronic neuroinflammation to brain function remain poorly defined. This dissertation examines how inflammation independently alters large-scale neural activity and behavior, focusing on interactions between the hippocampus (HPC) and anterior cingulate cortex (ACC), regions essential for memory and executive processes. Using in vivo electrophysiological techniques in a rodent model, this study compares the effects of short-term (acute) and prolonged (chronic) neuroinflammatory states, induced via Poly I:C, on neural oscillations, regional coherence, and spatial coding. Findings reveal that even transient inflammation …

Quantifying Biocrust Evaporation In Arid Lands By Combining Thermal Imaging And Lysimeter Measurements, Rebekah C. Magness

UNLV Theses, Dissertations, Professional Papers, and Capstones

Biological soil crusts (biocrusts) are miniature ecosystems of living organisms incorporated within the soil matrix and established in the topmost millimeters of the soil surface. Biocrust plays a critical role in the hydrologic processes in arid lands, yet the extent to which it increases or decreases evaporation remains unclear. To gain a better understanding of the impact of biocrust on evaporation compared to bare soil, I studied a cyanobacteria-dominated biocrust patch surrounded by bare soil atop a lysimeter in the Mojave Desert near Las Vegas, Nevada. Using high-resolution thermal imaging, and the known latent heat flux from the lysimeter, I …

Geometric And Proximity Based Substrate Targeting By Cullin-Ring Ligases, Jerry Li

UNLV Theses, Dissertations, Professional Papers, and Capstones

Homeostasis, the process of maintaining stable biochemical and biophysical conditions, is a fundamental facet of cellular viability. Biochemical homeostasis is critical to support the biological functions that sustain living organisms. Protein ubiquitylation is one of the primary cellular pathways that regulate protein homeostasis and turnover. Ubiquitylation is initiated through the conjugation of a small globular protein known as ubiquitin, onto a given substrate. There exists a myriad of cellular fates that ubiquitylated proteins may undergo, but the most widely studied pathway is protein degradation, whereby a ubiquitylated protein substrate is shunted to a large macromolecular protease known as the proteasome, …

Ankimedbench: Evaluating Hierarchical Medical Knowledge In Language Model Embeddings, Neel Patel

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite achieving over 90% accuracy on medical benchmarks, recent studies show physicians cannot effectively leverage language models to improve clinical reasoning. Current benchmarks test isolated factual recall, but clinical practice requires hierarchical navigation through diagnostic categories—starting broad and narrowing systematically from chest pain to cardiovascular pathology to myocardial infarction to specific STEMI types. Existing evaluations cannot measure whether models preserve this taxonomic structure essential for clinical reasoning.

We introduce AnkiMedBench, built from 16,512 medical flashcards used by students preparing for licensing exams. Cards are organized across six hierarchy levels spanning 16 broad medical specialties to 672 specific diseases and conditions. …

Deciphering The Crl Code: Novel Mechanisms Of Canonical And Non-Canonical Ubiquitylation, Nicholas Wayne Purser

UNLV Theses, Dissertations, Professional Papers, and Capstones

Protein degradation is a fundamental process required for maintaining cellular homeostasis in eukaryotic organisms. In humans, distinct cell types exhibit unique proteomic landscapes that are dynamically balanced by the continual synthesis and degradation of proteins. The timely removal of damaged, misfolded, or old proteins is essential to permit new protein synthesis and to ensure proper cellular function.

Central to this regulatory network is ubiquitylation, a highly conserved posttranslational modification system that governs protein stability and function across all eukaryotic cells. Through the covalent attachment of ubiquitin molecules to protein substrates, this system modulates a broad range of biological processes, including …