Digital Commons Network^™

Extracellular Matrix-Mycaf Signatures Correlate With Resistance To Neoadjuvant Apd-L1 Immune Checkpoint Inhibition With Durvalumab + Metformin In Hpv+ Hnscc, Pablo Llerena, Hani Samarah, Kathryn Nunes, Zhao Lin, Kelly Bridgham, Sruti Tekumalla, Amiti Jain, Larry A. Harshyne, Sanket Kumar Shukla, Ioannis Vathiotis, Madalina Tuluc, Stacey Gargano, John R. Eisenbrey, Scott W Keith, David Cognetti, Voichita Bar-Ad, Adam J. Luginbuhl, Rita S. Axelrod, Rajanikanth Vadigepalli, Hushan Yang, Diana Whitaker-Menezes, Megan Roche, My G. Mahoney, Athanassios Argiris, Charalambos C. Solomides, Jennifer Johnson, Md, Mouadh Barbirou, Amanda Miller, Andrew P. South, Ramkrishna Mitra, Alban J Linnenbach, Ubaldo E. Martinez-Outshoorn, Joseph Curry

Department of Otolaryngology - Head and Neck Surgery Faculty Papers

PURPOSE: Immune checkpoint inhibitors (ICI) have demonstrated clinical benefit in head and neck squamous cell carcinoma (HNSCC); however, single-agent efficacy is limited, leaving significant unmet needs. Metformin may synergize with ICIs, offering promise to improve response rates. We leveraged multiomic data from a randomized, presurgical neoadjuvant trial (NCT03618654) evaluating a single infusion of the anti-PD-L1 ICI durvalumab with or without daily, standard dose metformin in previously untreated, nondiabetic patients with HNSCC to understand predictors of response and the effect of combination therapy.

PATIENTS AND METHODS: Clinical, pathologic, and correlative data were analyzed to investigate response and resistance mechanisms. We present …

Migratory Songbirds As Potential Ectozoochorous Protist Dispersal Vectors, Silas E. Fischer, Joy J. Jackson, Elise C. Hoffman, Henry M. Streby, Trisha L. Spanbauer

Earth and Environmental Sciences Faculty Publications

Protist biogeography, speciation, and systematics continue to generate debate and inquiry because protist distributions and dispersal remain poorly resolved. Identifying potential vectors and basibionts for epibiont protists would contribute to our limited understanding of their ecology. Migratory animals seasonally link disparate landscapes, incidentally transporting other organisms in the process. Waterbirds are known microbe dispersers, but evidence for other avian groups is limited-such as taxa that often migrate longer distances. We asked whether terrestrial songbirds (Passeriformes) host diatoms (Bacillariophyta) by sampling tail plumage of four thrush species (Hermit Thrush Catharus guttatus, Swainson's Thrush C. ustulatus, Wood Thrush Hylocichla mustelina, American Robin …

Pronatalism In The United States: How Political Ideals Surrounding Family And Reproductive Health Care Contribute To Neglect In The Foster Care System, Carson Sebree

Undergraduate Honors Theses

Within the past decade, conservative reproductive politics in the United States have experienced an ideological shift from pro-life toward pronatalism. This has been intensified through the rollback of reproductive rights and the rise of Christian nationalism. However, there has been no commensurate additional funding for the foster care system. This project asks the interrelated questions of: “how is pronatalism linked to neglect within the foster care system?; and, how do theories of democratic care highlight the necessity to rethink support for the foster care system and create policies that will address its shortcomings, given the rise of pronatalist aw and …

Fabrication Of Three-Dimensional Seaweed-Based Scaffolds And Evaluation Of Cell Attachment And Viability For Cultured Meat Applications, Srishti Tandon

Honors Scholar Theses

Global demand for animal protein is increasing rapidly, underscoring the need for sustainable meat production. Cultured meat is a promising alternative to traditional meat production techniques, but it requires optimization before it can be implemented on a large scale. Scaffolds are an important component for making cultured meat, as they provide structural support for cell attachment and mimic the texture of meat. Scaffolds need to be biocompatible, mechanically supportive, and biochemically active to promote proper cell adhesion, proliferation, and differentiation. This project investigated brown seaweed extract (SWE) hydrogels as a scaffold for cultivated meat applications and compared their mechanical and …

Rab32c Mediates Osmoregulation And Calcium Homeoastasis In Dictyostelium Discoideum, Ashley Esparza

Theses and Dissertations

Vesicular trafficking is a fundamental process essential to cell viability and dictates roles in both cellular and tissue function in multicellular organisms. To further understand various vesicular trafficking processes, our lab focuses on the moderators of these processes, Rab GTPases, using the model organism Dictyostelium discoideum. This dissertation focuses explicitly on the uncharacterized protein Rab32C, a homolog of human Rab32. While several Rab family members have been well defined, the functionality of Rab32C remains poorly understood. This project investigated both the subcellular localization and functional role of Rab32C with biochemical, imaging, and molecular assays. Results from this study provide evidence …

Plant Preservation: The Contribution Of Bacteriophage And Transposons To Pathogenic Xanthomonas Evolution, And The Demographic And Reproductive Analysis Of Castilleja Parvula, Ciara A. Green

Theses and Dissertations

Plant preservation, whether through disease research or endemic extinction analyses, plays an important role in the relationship between humans and our surrounding environment. In these analyses, both the role of mobile elements in the evolution of pathogenic Xanthomonas sp. bacteria, and the demographic and reproductive analysis of Castilleja parvula, an imperiled alpine plant, are evaluated. Xanthomonas species are one of the top agricultural threats, and are known to evolve rapidly. Until now, the contributions of mobile elements and particularly bacteriophage have not been thoroughly evaluated. The contribution of these agricultural diseases to food insecurity and the devastation of crops that …

Understanding The Relationship Between Mental Health And Criminal Justice Involvement: Pathways, Disparities, And Improving System Responses, Haley Bly

Theses

This capstone project examines the complex relationship between mental health and involvement in the criminal justice system, emphasizing how pathways, external conditions, structural inequities, and system responses interact to shape long-term outcomes for persons with mental illness (PwMI). While mental illness alone is not a predictor of criminal behavior, the intersection between psychological disorders, social strain, stigma, and systemic failures significantly heightens the risk of criminal justice involvement. Combining four working papers, this capstone examines these relationships across individual, environmental, institutional, and community levels, ultimately arguing that treatment and rehabilitative-centered reforms are essential for improving the experiences of individuals with …

Elucidating The Role Of Pbaf Chromatin Remodeling Subunit Arid2 In B Cell Development, Rachel Paolini

Arts & Sciences Graduate Student Theses and Dissertations

B cells are key components of the adaptive immune system that mediate humoral immunity through the production of antigen-specific antibodies. The generation of functional B cells involves multiple stages of differentiation across distinct anatomical niches, requiring precise regulation of microenvironmental signals and intrinsic transcriptional networks. SWI/SNF chromatin remodeling complexes have emerged as key regulators of B cell lineage commitment by modulating the accessibility of transcriptional programs required for differentiation and maturation. However, the specific roles of individual SWI/SNF subunits and distinct complexes within early B cell differentiation remain poorly understood. In this thesis, I investigated the function of Arid2, an …

Trauma Beyond Time: Temporal Constructs In Holocaust Testimonies, Sarah Seiselmyer-Snyder

Purdue University Press Books

Trauma Beyond Time: Temporal Constructs in Holocaust Testimonies challenges our understanding of what it means to be a Holocaust survivor, arguing that the term “post-Holocaust” fundamentally misrepresents survivors’ experiences. Through careful analysis of Holocaust literature and testimony, this book reveals how trauma persists across generations, defying conventional historical timelines. For those who perished, there can be no “after” to the Holocaust—their stories were violently ended. Yet for survivors, the Holocaust didn’t simply conclude in 1945. Their experiences demonstrate how trauma continues to shape lives decades later, making “post-Holocaust” a misleading concept that fails to capture their ongoing reality. Using the …

Applied Research For Corn Production In Indiana, 2024, Daniel Quinn

Purdue University Press Books

The 2024 edition of Applied Research for Corn Production in Indiana offers accessible, research-based tips for farmers who want to improve corn production practices by using applied field-research trials. Daniel Quinn and the Purdue University Corn Agronomy team reveal practical ways to boost yields, reduce costs, and improve sustainability on the farm. Their findings are derived from applied research trials across the state and relate to important topics such as planting practices, fertilizer use, crop nutrition, cover crops, and new technologies. Applied Research for Corn Production in Indiana distills complex research into clear insights and supplies corn producers with effective …

Decisions That Shape Supply Chains, Nicole J. Olynk Widmar, Michael L. Smith, Erin Robinson

Purdue University Press Books

What drives consumer decisions, and how do those decisions ripple through our food and agricultural systems? In Decisions That Shape Supply Chains, readers are invited to look beyond conventional models of behavior and explore the complex, sometimes counterintuitive factors influencing real-world consumer choices. Drawing on behavioral science and applied research, this volume examines how decisions made in grocery aisles, drive-through lines, and online shopping carts ultimately inform what gets planted, processed, packaged, and promoted across the food-supply chain. From attitudes toward GMO foods to parenting as a form of consumerism and emotional decision-making under stress to the environmental tradeoffs consumers …

Teaming With Insects: Entomology For Grades 3-12, Natalie J. Carroll, Christian Y. Oseto, Timothy J. Gibb

Purdue University Press Books

Teaming With Insects: Entomology for Grades 3–12 is written for youth who enjoy learning about and studying science and nature. Insects have been around for millions of years and have evolved and adapted to many different habitats. Adaptations involving their anatomy, physiology, and behavior are what make insects so diverse and interesting. More than 1 million species of insects are known to scientists, and they believe there may be up to 40 million more we have yet to discover. Most people consider insects pests, and some insects do damage to homes, plants, crops, and stored foods. Others harm humans and …

Soil And Water Education For Grades 3-12, Natalie J. Carroll, Christian Y. Oseto, Timothy J. Gibb

Purdue University Press Books

Soil and Water Education for Grades 3–12 was written for youth who enjoy learning about science and two critical natural resources: soil and water. Level 1 introduces basic terms and concepts, and is intended for youth in grades 3–5. Activities focus on understanding important soil and water processes. Designed for students in grades 6–8, Level 2 offers readers more concrete examples of advanced soil and water concepts. The exercises in Level 3, which is geared toward grades 9–12, are divided into sections based on how readers might use the information they have learned, placing them in the shoes of homeowners, …

Consumer Lessons From A Pandemic, Nicole J. Olynk Widmar, Michael L. Smith, Erin Robinson

Purdue University Press Books

What did we learn about consumer behavior when the world was turned upside down due to COVID-19? Consumer Lessons From a Pandemic examines how a global crisis exposed and reshaped the values, priorities, and decision-making patterns of everyday people. From disrupted routines to supply-chain shocks, this volume explores the consumer behaviors that emerged in response to extreme uncertainty and how those behaviors continue to evolve. Topics include pandemic-induced grocery spending shifts, the importance of consumer trust, lessons from the infant-formula shortage, and the rise of remote work both as a preference and a negotiation point.

Fundamental Hydraulics Principles For Agricultural Systems Management And Technology, Robert M. Stwalley Iii, Roger Tormoehlen

Purdue University Press Books

Hydraulic systems have spread throughout modern technology, particularly in mobile equipment. The exercises presented in Fundamental Hydraulic Principles for Agricultural Systems Management and Technology are designed for the second-generation Parker Hydraulic Trainer to provide a basic understanding of hydraulic components and systems for technology and engineering students. Readers will learn how hydraulic pumps function, how linear actuators and their control circuits work, and how hydraulic motors operate and are controlled. Readers are also provided with the opportunity to attempt more advanced exercises. Aligned with beginning technology-based experiential hydraulics courses, this book emphasizes familiarity with common hydraulic components and circuit diagrams, …

Building Your Epic Life: Your Journey, Your Way, Your Masterpiece, Luciano Castillo

Purdue University Press Books

Building Your Epic Life empowers young people to understand that failure is an inevitable—and essential—part of the journey to success. The author shares his own challenges and struggles, showing that no path to success is linear and without setbacks. The book teaches the value of building a healthy body, mind, and spirit, and includes exercises that offer actionable plans for individuals to realize a meaningful, self-defined life based on their core values. A proven roadmap workbook and short lectures guide readers through a series of practical steps to discover their purpose, vision, and understand the value of mentorship—and why each …

Method Development And Optimization For The Detection Of Synthetic Cannabinoids In Hair Using Lc-Msms, Linda K. Obeng

Student Theses

Synthetic cannabinoids represent one of the most prevalent and high-risk classes of New Psychoactive Substances (NPS), continuously evolving in structure and potency. Their widespread presence in seized materials and toxicology casework underscores the growing need for reliable analytical methods capable of detecting these compounds in biological matrices. Hair offers several advantages for drug testing, including a long detection window, minimal invasiveness, and resistance to adulteration; however, detecting synthetic cannabinoids in hair remains challenging due to their low incorporation levels and structural diversity. This study focuses on the method development and optimization of an LC-MS/MS technique for the detection of selected …

Soil Fertility Forecasting With Neutrosophic-Based Uncertainty Management, Franklin Parrales-Bravo, Roberto Tolozano-Benites, Dayron Rumbaut-Rangel

Neutrosophic Sets and Systems

This study presents a machine learning framework that combines Random Forest classification with neutrosophic logic to predict soil fertility from 16 physicochemical properties. The model achieves robust classification accuracy (95%) while introducing a novel uncertainty quantification mechanism through neutrosophic truth (T ), indeterminacy (I) and falsity (F ) values derived from prediction probabilities, assigning high-confidence (T = 0.9) to probabilities ≥0.9, indeterminacy (I = 0.3) to borderline cases (0.5≤p

Cross-Country Differences In Adolescent Dietary Patterns And Body Mass Index: Spain And The United States, Rosa I. Chavez Jimenez

Honors Scholar Theses

In 2019, NCDs accounted for 38.8% of total global deaths in adolescents aged 10-24, and in 2024, the World Health Organization (WHO) reported that over 390 million youth were overweight or obese worldwide, highlighting the urgency of addressing poor nutrition and sedentary behaviors early in life. There is an extensive amount of research suggesting that the Mediterranean Diet (MD) is related to lowering NCDs and its risk factors. Thus, the present study explored cross-country differences in dietary patterns and Body Mass Index (BMI) between youth in Spain and the United States (US), two countries with contrasting dietary traditions: the Mediterranean …

Oxytocin Varies Across The Life Course In A Sex-Specific Way In A Human Subsistence Population, Abigail E. Colby, Dominik C. Jud, Valerie Baettig, Jordan S. Martin, Camila Scaff, Michael D. Gurven, Benjamin C. Trumble, Bret A. Beheim, Paul L. Hooper, Daniel K. Cummings, Hillard Kaplan, Jonathan Stieglitz, Arnulfo Cary Ista, Adrian V. Jaeggi

ESI Publications

Oxytocin, a hormone linked to reproduction and health, may mediate life-history trade-offs across the human life course. Yet, how oxytocin naturally varies with age remains poorly understood. Here, working with the Tsimane, forager-horticulturalists of lowland Bolivia, we collected the largest sample of oxytocin measurements to date (n = 1,242 samples, n = 405 individuals, age = 2 to 84 y, 51% female), and i) examined how oxytocin varies throughout the life course in females and males, and ii) investigated potential drivers of age- and sex-specific variation. Our sample provides rare insight into the relationship between oxytocin and age in a …

The Evolution Of Southern Ocean Net Primary Production In A Changing Climate: Challenges And Opportunities, Alessandro Tagliabue, Thomas Ryan-Keogh, Alex Baker, Thomas S. Bibby, Chris Follett, Maeve C. Lohan, Alberto Naveira-Garabato, Daniel J. Mayor, Angela Milne, C. Mark Moore, Simon Ussher

School of Geography, Earth and Environmental Sciences

Net primary production in the Southern Ocean plays a critical role in governing ecosystem production, the biological carbon pump, and global biogeochemical cycles. Recent work has advanced our understanding of novel factors regulating Southern Ocean net primary production and the regional physiological adaptations employed by Southern Ocean phytoplankton in terms of their photosynthetic strategies and resource acquisition. Here we assess trends in Southern Ocean net primary production from different remote sensing algorithms and bgc-Argo floats to compare them to the latest Earth System Models used to forecast future changes under three different future climate scenarios. Overall, remote sensing and bgc-Argo …

Objective Vs. Perceived Maternal Smartphone Use And Observed Mother-Infant Interaction Quality, Alison K. Ventura, Lara N. Wolfers, Sarah M. Coyne, Rachel Pfafman, Sabrina Uva, Karla I. Ceja Almontes, Aniruddha S. Shinde, Adam M. Galovan, Brandon Mcdaniel

Health Services and Informatics Research

Introduction:

Prior research links maternal smartphone use to reduced sensitivity and responsiveness to infant cues, but emerging evidence suggests that mothers' perceptions of their smartphone use - such as feelings of empowerment or distress - may also shape the quality of mother-infant interactions. This study examined how both objective and perceived smartphone use related to mother-infant interaction quality in naturalistic settings.

Method:

Participants were 147 mother-infant dyads from a longitudinal study of smartphone use and infant development. When infants were 2 months old, mothers completed 5 days of ecological momentary assessment (EMA), reporting time spent with their infant, perceived smartphone-related …

Mitochondrial Complex Ii Orchestrates Divergent Effects In Cd4+ And Cd8+ T Cells, Keisuke Seike, Shih-Chun A Chu, Yuichi Sumii, Takashi Ikeda, Meng-Chih Wu, Laure Maneix, Dongchang Zhao, Yaping Sun, Marcin Cieslik, Pavan Reddy

Faculty, Staff and Students Publications

Mitochondrial metabolism orchestrates T cell functions, yet the role of specific mitochondrial components in distinct T cell subsets remains poorly understood. Here, we explored the role of mitochondrial complex II (MC II), the only complex from the electron transport chain (ETC) that plays a role in both ETC and metabolism, in regulating T cell functions. Surprisingly, MC II exerts divergent effects on CD4+ and CD8+ T cell activation and function. Using T cell-specific MC II subunit, succinate dehydrogenase A-deficient (SDHA-deficient) mice, we integrated single-cell RNA-seq and metabolic profiling, with in vitro and in vivo T cell functional assays to illuminate …

A Neutrosophic Random Forest Approach For Preeclamptic Risk Prediction With Uncertainty Quantification, Franklin Parrales-Bravo, Rosangela Caicedo-Quiroz, Lorenzo Cevallos-Torres, Leonel Vasquez-Cevallos, Dayron Rumbaut-Rangel

Neutrosophic Sets and Systems

This study presents a novel integration of Random Forest with neutrosophic logic to improve preeclampsia risk prediction while quantifying prediction uncertainty. Using clinical data from 352 patients, the model achieved 72.73% accuracy with high sensitivity (0.898) in identifying control cases, though with lower specificity (0.235) for preeclampsia detection. Key predictors identified were birthweight and hypertension his- tory, aligning with clinical knowledge. The neutrosophic framework successfully categorized predictions into truth (T), indeterminacy (I), and falsity (F) components, revealing that 90% confidence predictions showed T = 0.9 while uncertain cases (0.5 ≤ p < 0.9) demonstrated elevated indeterminacy (I = 0.3). The main contributions include: 1) an interpretable uncertainty quantification method for clinical predictions, 2) validation of key risk factors through feature importance analysis, and 3) a practical framework for identifying cases requiring additional clinical evaluation. This approach demonstrates significant potential for enhancing decision-making in maternal healthcare.

Neutrosophic Plithogenic Hypotheses On Bacterial Resistance To Conventional And Laser-Assisted Treatments, Emma Arroyo Lalama, Edison Haro Pujos

Neutrosophic Sets and Systems

Enterococcus faecalis is a common endodontic pathogen that causes unsuccessful treatments because standard methods of debridement cannot remove it from the root canal system. Methods of debridement are effective relative to debriding multifactorial bacterial biofilms in apical pathogens. Therefore, neutrosophic plithogenic hypotheses are proposed to measure the uncertainty and variability of the bacterial response. Therefore, this work attempted to determine the impact of laser treatment (diode and Er:YAG) as an adjunct agent relative to and in conjunction with traditional irrigants in the reduction of E. faecalis. The diode and Er:YAG laser support increased disinfection efficacy over standard irrigants as they …

Triadic Dynamics Of Clinical Decisions In Apical Surgery Based On Neutrosophic N-Alectic, Emma Arroyo Lalama, Edison Haro Pujos

Neutrosophic Sets and Systems

This study explored the creation of a clinical decision-making model in apical surgery via Neutrosophic N-Alectic, blending affirmative (operate), negative (observe), and neutral (retry conventional endodontics) based on equivocal findings to offer potential solutions to the presentation of periapical lesions. The methodology consisted of dialectic considerations of previous surgeries retrospectively, meaning attributable elements such as lesion severity and response to previous treatment were assessed via a neutrosophic approach to assess the degree of truth, degree of falsity and degree of indeterminacy across all treatment options. The main findings are the neutrosophic model assists in determining the best decisions based on …

Intercultural Education From Ancestral Logic: Application Of The Ayni Method Multi-Neutrosophic To Strengthen Mixed Methodology In The Waorani Community, Johanna Estefanía Calle Imbaquingo, Karen Milagros Díaz Salambay, Jordy Alexis Vargas Yumbo, Kevin Christopher Carrasco Azogue, Otto F. Von Feigenblatt

Neutrosophic Sets and Systems

Research aimed at determining the Ayni method Multi-Neutrosophic by which a successful blended learning experience enhances multicultural education respecting Ancestral Logic of the Waoranis to create a hybridization of Ancestral Logic and institutional and classroom learning to preserve their cultural identity. A qualitative descriptive-legal research approach was utilized. The results of the documentary analysis included requirements from Ecuador (Constitution, ILO Convention 169) and semi-structured interviews with Waorani leaders and teachers, Triangulation through participant observation of the educational activities taught in the Waorani community. The Ayni method Multi-Neutrosophic was cultural reciprocity and neutrality established through indeterminacies in the blended Ancestral teachings …

Hyperbolic Geometry And Neutrosophic Trigonometry: A Unified Approach To Uncertainty Management In Geometric Spaces, Yismandry González Vargas, Diana Padrón Carrasco

Neutrosophic Sets and Systems

This paper addresses the challenge of modeling uncertainty in hyperbolic geometry, where non-Euclidean properties, such as angle sums in triangles smaller than 180°, complicate traditional trigonometric calculations. The relevance of this topic lies in its application in fields such as cosmology, robotics, and signal processing, where curved spaces and imprecision are common. Although the literature has explored fuzzy geometry and trigonometry under uncertainty, it lacks a framework that integrates negative curvature with explicit indeterminacy. To overcome this gap, a methodology is proposed that combines hyperbolic geometry with neutrosophic trigonometry, using neutrosophic sets (T, I, F) to represent angles and calculate …

Characterization Of The Electronic Structure Of Metal–Organic Framework Mil-125 And Its Derivatives Using Soft X-Ray Spectroscopies, Jennifer Alexia Napoles

UNLV Theses, Dissertations, Professional Papers, and Capstones

Metal–organic frameworks (MOFs) are highly porous, three-dimensional networks composed of coordinated metal clusters and organic ligand subunits. While tens of thousands of MOFs have been synthesized, the Ti(IV)-based MOF MIL-125 has garnered scientific interest due to the observed changes to its optical and photocatalytic properties upon chemical modification. For example, upon UV irradiation in the presence of an alcohol, MIL-125 undergoes a photochromic color change to a photodoped state that has been associated with the storage of charge in the form of Ti(III) sites. Another example is exemplified by the amine group functionalization of the 1,4-benzenedicarboxylate (BDC) linker of MIL-125 …

Design And Development Of Biomimetic Hydrogel Interfaces For Enhanced Bioelectrical Signal Acquisition, Daniela Nikoloska

UNLV Theses, Dissertations, Professional Papers, and Capstones

Every second, human skin processes over one million sensory signals while maintaining properties such as electrical conductivity, mechanical adaptability, and regenerative capability that surpass all synthetic materials. Contemporary bioelectronic devices prove inadequate when contacting skin surfaces due to poor adhesion and electrical contact issues that prevent effective sensing. Despite advancements in wearable and bioelectronic technologies, current devices face major drawbacks when interfacing with human skin, particularly in maintaining firm adhesion, conformability, and low-noise electrical signal acquisition.

This research focuses on the development of a biomimetic hydrogel-based interface for bioelectronic sensing. Specifically, a hybrid hydrogel system composed of polydopamine (PDA)- doped …