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Articles 151951 - 151980 of 820922
Full-Text Articles in Entire DC Network
Classics And Social Media, Owen Ewald
Classics And Social Media, Owen Ewald
Speakers & Events
The 2022 Marston Lecture will focus on the creations and curations of Classics students — memes, red-pill communities, and the dark academia aesthetic. This lecture will discuss these groups and themes for educational purposes only, not for advocacy or endorsement.
Harnessing The 4dee Framework To Redesign An Introductory Ecology Course In A Changing Higher Education Landscape, Nathan Ruhl, Patrick Crumrine, Jennifer Oberle, Courtney Richmond, Shelly Thomas, Sara Wright
Harnessing The 4dee Framework To Redesign An Introductory Ecology Course In A Changing Higher Education Landscape, Nathan Ruhl, Patrick Crumrine, Jennifer Oberle, Courtney Richmond, Shelly Thomas, Sara Wright
College of Science & Mathematics Departmental Research
As higher education undergoes rapid and fundamental change, eco-educators need to be prepared to promote the inclusion of the ecological sciences in the biological sciences curriculum of the future. Here, we present an instructional alignment for an introductory ecology course, which is informed by and integrated with the Four-Dimensional Ecology Education (4DEE) Framework. Our instructional alignment was created collaboratively among faculty involved in teaching the course and emphasizes the relevance and utility of the ecological sciences. We believe that this approach positions the ecological sciences for continued success and inclusion in the biological sciences curriculum of tomorrow.
Two University Of Dayton Students First To Complete New Life Science Quality Assurance Minor, Allison Brace
Two University Of Dayton Students First To Complete New Life Science Quality Assurance Minor, Allison Brace
College of Arts and Sciences Newsroom
Abigail Lee, a senior biology major, and Hayley Jesse, a junior chemical engineering major, are the first students to complete the University of Dayton’s quality assurance in the life science industries minor.
Gwu Departments Of Theatre Arts And Music Present Spring Musical, ‘Quilters’, Office Of University Communications
Gwu Departments Of Theatre Arts And Music Present Spring Musical, ‘Quilters’, Office Of University Communications
Gardner-Webb NewsCenter Archive
“Quilters,” presented by the Gardner-Webb University Departments of Theatre Arts and Music, is a musical with some unique characteristics and challenges for the small cast. Set in the 1850s, the show celebrates the pioneering women who cared for their families on the difficult, and sometimes disastrous, journey west. Performances will be in Dover Theatre on Feb. 24-26 at 7:30 p.m. and Feb. 27 at 2:30 p.m.
Is Marital Quality Related To Physical Activity Across The Life Course For Men And Women?, Patricia A. Thomas, Elizabeth Richards, Anna K. Forster
Is Marital Quality Related To Physical Activity Across The Life Course For Men And Women?, Patricia A. Thomas, Elizabeth Richards, Anna K. Forster
School of Nursing Faculty Publications
Objectives: Although physical activity is linked to multiple health outcomes, a majority of Americans do not meet physical activity guidelines, often with precipitous declines among older adults. Marital quality is a less-explored, but important, factor that may influence physical activity, as spouses often influence each other’s health behaviors. Methods: We use nationally representative panel data to investigate whether positive and negative dimensions of marital quality influence physical activity, and whether age and gender moderate these relationships. Results: We find that both marital support and strain are related to higher odds of more frequent active exercise and walking, pointing to the …
Gli Weekly, February 8, 2022, Franke Global Leadership Initiative
Gli Weekly, February 8, 2022, Franke Global Leadership Initiative
GLI Weekly
IDS Career Development Series: "Bridging the Gap: Environmental Education and International Development" -- Alternative Spring Break -- Study Abroad Fair -- Summer Session 2022 at Flathead Lake Biological Station
The Parthenon, February 8, 2022, Tyler Spence, Connor Woodruff, Tyler Kennett, Evan Green, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon, Abby Ayes, Alaina Laster, Isabella Robinson
The Parthenon, February 8, 2022, Tyler Spence, Connor Woodruff, Tyler Kennett, Evan Green, Shauntelle Thompson, Rafael Alfonso, Abby Hanlon, Abby Ayes, Alaina Laster, Isabella Robinson
The Parthenon
No abstract provided.
The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho
The Number Of Tree Species On Earth, Roberto Cazzolla Gatti, Peter B. Reich, Javier G.P. Gamarra, Tom Crowther, Cang Hui, Albert Morera, Jean Francois Bastin, Sergio De-Miguel, Gert Jan Nabuurs, Jens Christian Svenning, Josep M. Serra-Diaz, Cory Merow, Brian Enquist, Maria Kamenetsky, Junho Lee, Jun Zhu, Jinyun Fang, Douglass F. Jacobs, Bryan Pijanowski, Arindam Banerjee, Robert A. Giaquinto, Giorgio Alberti, Angelica Maria Almeyda Zambrano, Esteban Alvarez-Davila, Alejandro Araujo-Murakami, Valerio Avitabile, Gerardo A. Aymard, Radomir Balazy, Chris Baraloto, Jorcely G. Barroso, Meredith L. Bastian, Philippe Birnbaum, Robert Bitariho
Faculty Publications
One of the most fundamental questions in ecology is how many species inhabit the Earth. However, due to massive logistical and financial challenges and taxonomic difficulties connected to the species concept definition, the global numbers of species, including those of important and well-studied life forms such as trees, still remain largely unknown. Here, based on global ground-sourced data, we estimate the total tree species richness at global, continental, and biome levels. Our results indicate that there are ∼73,000 tree species globally, among which ∼9,000 tree species are yet to be discovered. Roughly 40% of undiscovered tree species are in South …
February 8, 2022 Ereporter, University Of Alabama At Birmingham
February 8, 2022 Ereporter, University Of Alabama At Birmingham
eReporter (campus newsletter)
No abstract provided.
An Inkjet Printed Flexible Electrocorticography (Ecog) Microelectrode Array On A Thin Parylene-C Film, Yoontae Kim, Stella Alimperti, Paul Choi, Moses Noh
An Inkjet Printed Flexible Electrocorticography (Ecog) Microelectrode Array On A Thin Parylene-C Film, Yoontae Kim, Stella Alimperti, Paul Choi, Moses Noh
Electrical and Computer Engineering Faculty Publications
Electrocorticography (ECoG) is a conventional, invasive technique for recording brain signals from the cortical surface using an array of electrodes. In this study, we developed a highly flexible 22-channel ECoG microelectrode array on a thin Parylene film using novel fabrication techniques. Narrow (<40 >µm) and thin (<500 >nm) microelectrode patterns were first printed on PDMS, then the patterns were transferred onto Parylene films via vapor deposition and peeling. A custom-designed, 3D-printed connector was built and assembled with the Parylene-based flexible ECoG microelectrode array without soldering. The impedance of the assembled ECoG electrode array was measured in vitro by electrochemical impedance …500>40>
Minutes, Curriculum Committee Meeting, Tuesday, February 8, 2022, Curriculum Committee
Minutes, Curriculum Committee Meeting, Tuesday, February 8, 2022, Curriculum Committee
Curriculum Committee Minutes
No abstract provided.
Student Senate Meeting Minutes February 8, 2022, Student Senate-Winona State University
Student Senate Meeting Minutes February 8, 2022, Student Senate-Winona State University
Student Senate Meeting Minutes
This document is the official Winona State University Student Senate Minutes February 8, 2022.
Unravelling Causes Of Poor Crop Response To Applied N And P Fertilizers On African Soils, Gudeta W. Sileshi, Job Kihara, Lulseged Tamene, Bernard Vanlauwe, Elijah Phiri, Bashir Jama
Unravelling Causes Of Poor Crop Response To Applied N And P Fertilizers On African Soils, Gudeta W. Sileshi, Job Kihara, Lulseged Tamene, Bernard Vanlauwe, Elijah Phiri, Bashir Jama
All Peer-Reviewed Publications
A number of studies across sub-Saharan Africa have recently reported poor crop responses and low agronomic use efficiencies of applied nitrogen (AEN), phosphorus (AEP) and potassium (AEK). However, the conditions under which non-responsiveness occurs, its underlying causes and its probability of occurrence on different soil types are not well understood. Using data from 542 sites and 14 soil types in 23 African countries, we provide novel insights into the linkage between lack of response to applied N, P and K, the mineralogy of soils and their resilience to erosion. We estimated mean responses as well as the probabilities (φ) of …
A Phenomenological Study Of The Impact Of Covid-19 On Colleges And Universities In The United States, Erin D. Lynn
A Phenomenological Study Of The Impact Of Covid-19 On Colleges And Universities In The United States, Erin D. Lynn
Student Theses and Dissertations
2019-nCoV (COVID-19) is a novel coronavirus first identified in the Wuhan, Hubei Province, that developed into a global pandemic in the year 2020. The impact in early spring compromised many higher education institutions, forcing some to shift to remote operations and leaving schools to determine when, how, and to what capacity they could safely reopen while also making contingency plans for ongoing or future periods of disruption. As is often the case with disasters and public health crises, not all who are affected are impacted uniformly, and the disproportionate ways in which people and communities are affected influence resiliency and …
Spring Migration Behavior And Summer Habitat Associations Of Female Indiana Bats (Myotis Sodalis) In Arkansas, Heather N. Custer
Spring Migration Behavior And Summer Habitat Associations Of Female Indiana Bats (Myotis Sodalis) In Arkansas, Heather N. Custer
Student Theses and Dissertations
Since 1967, the Indiana bat (Myotis sodalis) has been federally listed. Range-wide research continues to expand our understanding of the behaviors of the species, but knowledge gaps still remain. Specifically, information regarding spring migration behavior and associated summer habitat of female Indiana bats that overwinter in Arkansas is lacking. Accordingly, objectives of this research included determining direction and distance of migrating female Indiana bats, locating maternity colonies and roosts, estimating maternity colony size, home ranges, and core areas. Migration directions and distances varied among bats, and a maternity colony was located in Arkansas in 2019 that subsequently used artificial roosts …
Investigation Of The Methylome Pattern Changes In Phytophthora Sojae Infected Soybean (Glycine Max), Shyaron Poudel
Investigation Of The Methylome Pattern Changes In Phytophthora Sojae Infected Soybean (Glycine Max), Shyaron Poudel
Student Theses and Dissertations
Phytophthora stem and root rot (PSR), a soybean disease causes annual losses of up to $250 million in the United States alone. Using the Rps (resistant to Phytophthora sojae) gene in soybean is the main management technique. However, Rps genes are only effective until 8-15 years in the field. Therefore, further understanding of the Rps gene regulation and immune response in soybean is desperately needed. In this study, first, three commercial DNA methylation detection kits were examined on soybean (cultivar Williams 82,which carries Rps1k) DNA samples. All three kits provided libraries with excellent quality and coverage. Secondly, the differential DNA …
Unraveling The Anti-Inflammatory And Cardioprotective Mechanism Of Prenylated Stilbenoids From Peanut Hairy Root Cultures In Vitro And In Vivo, Md Rokib Hasan
Unraveling The Anti-Inflammatory And Cardioprotective Mechanism Of Prenylated Stilbenoids From Peanut Hairy Root Cultures In Vitro And In Vivo, Md Rokib Hasan
Student Theses and Dissertations
Stilbenoids are a non-flavonoid class of polyphenols that are important for their potential medicinal applications. Resveratrol, ione of the most well-studied compounds of this group, has various medicinal properties including anti-inflammatory, antioxidant, anti-cancer and many other properties. Prenylated stilbenoids which include arachidin-1 and arachidin-3 are produced as a defense response to biotic and abiotic stresses in peanut (Arachis hypogaea). Prenylation has been shown to enhance the biological activities of polyphenolic compounds and thus arachidins may have higher anti-inflammatory activity than resveratrol in addition to many other potential health applications. However, the molecular mechanism of the arachidins as an anti-inflammatory and …
A Marine Natural Capital Asset And Risk Register—Towards Securing The Benefits From Marine Systems And Linked Ecosystem Services, Siân E. Rees, Matthew Ashley, Andy Cameron, Tom Mullier, Chrissie Ingle, Jenny Oates, Aisling Lannin, Tara Hooper, Martin J. Attrill
A Marine Natural Capital Asset And Risk Register—Towards Securing The Benefits From Marine Systems And Linked Ecosystem Services, Siân E. Rees, Matthew Ashley, Andy Cameron, Tom Mullier, Chrissie Ingle, Jenny Oates, Aisling Lannin, Tara Hooper, Martin J. Attrill
School of Biological and Marine Sciences
No abstract provided.
A Cysteine Variant At An Allosteric Site Alters Mif Dynamics And Biological Function In Homo- And Heterotrimeric Assemblies, Erin Skeens, Georgios Pantouris, Dilip Shah, Ramu Manjula, Michael J. Ombrello, N. Karl Maluf, Vineet Bhandari, George P. Lisi, Elias J. Lolis
A Cysteine Variant At An Allosteric Site Alters Mif Dynamics And Biological Function In Homo- And Heterotrimeric Assemblies, Erin Skeens, Georgios Pantouris, Dilip Shah, Ramu Manjula, Michael J. Ombrello, N. Karl Maluf, Vineet Bhandari, George P. Lisi, Elias J. Lolis
Pacific Faculty Work
Macrophage migration inhibitory factor (MIF) is an inflammatory protein with various non-overlapping functions. It is not only conserved in mammals, but it is found in parasites, fish, and plants. Human MIF is a homotrimer with an enzymatic cavity between two subunits with Pro1 as a catalytic base, activates the receptors CD74, CXCR2, and CXCR4, has functional interactions in the cytosol, and is reported to be a nuclease. There is a solvent channel down its 3-fold axis with a recently identified gating residue as an allosteric site important for regulating, to different extents, the enzymatic activity and CD74 binding and signaling. …
Combatting Climate Change Through Conservation Easements, Claire Wright
Combatting Climate Change Through Conservation Easements, Claire Wright
Minnesota Journal of Law, Science & Technology
No abstract provided.
Individual, Social And Institutional Vulnerabilities In The Premature Infant Care At Home, Claudia Silveira Viera Ms, Leticia Pancieri Ms, Rosane Meire Munhak Da Silva Ms, Monika Wernet Ms, Maria Aparecida Munhoz Gaiva Ms, Debora Falleiros De Mello Ms
Individual, Social And Institutional Vulnerabilities In The Premature Infant Care At Home, Claudia Silveira Viera Ms, Leticia Pancieri Ms, Rosane Meire Munhak Da Silva Ms, Monika Wernet Ms, Maria Aparecida Munhoz Gaiva Ms, Debora Falleiros De Mello Ms
The Qualitative Report
The prematurity carries some difficulties for families during the preterm infant hospitalization, as well as, after hospital discharge. In this context, is required a specific knowledge about the preterm biological characteristics, family’s life conditions, health care, and social context. This study aims to analyze parent’s experiences on daily home care for preterm infants focusing on individual, social and institutional vulnerabilities. Descriptive qualitative study was developed through the hermeneutic perspective approach, in South of Brazil with six families, who had babies discharged from Neonatal Intensive Care Unit. Non-structured interviews were recorded in the home visit with 12 participants (parents) and genogram …
Toxical Effect Of Euphorbia Guyoniana Aqueous Extracts (Euphorbiaceae) On Mortality, Larval Development And Sexual Behavior Of Drosophila Melanogaster (Diptera: Drosophilidae), Chabi Lila, Habbachi Wafa, Tahraoui Abdelkrim
Toxical Effect Of Euphorbia Guyoniana Aqueous Extracts (Euphorbiaceae) On Mortality, Larval Development And Sexual Behavior Of Drosophila Melanogaster (Diptera: Drosophilidae), Chabi Lila, Habbachi Wafa, Tahraoui Abdelkrim
Journal of Bioresource Management
Euphorbia guyoniana (Boiss and Reut) is a plant of Euphorbiaceae family common throughout the northern Sahara and pre-desert regions. In traditional medicine, they are used in the treatment of various infections. Euphorbiaceae contain various chemical compounds families such as alkaloids, which give them a toxic effect. The toxic effects of seeds decoctions on mortality and development of 3rd instar larvae of Drosophila melanogaster are studied. A treatment by ingestion shows a good larvicidal activity of this extract. It was shown that the chemical compounds contained in the extract, act on the fly development cycle as most of pupae do not …
Preliminary Survey And Diet Analysis Of Anurans In The Riparian Zone Of Calayagon Watershed, Agusan Del Norte, Philippines, Jenessa Verna B. Salo, Chennie L. Solania
Preliminary Survey And Diet Analysis Of Anurans In The Riparian Zone Of Calayagon Watershed, Agusan Del Norte, Philippines, Jenessa Verna B. Salo, Chennie L. Solania
Journal of Bioresource Management
Watersheds are critical habitats for a diverse array of organisms. Among all the fauna, anurans are excellent biological indicators of environmental health. The community structure is often associated with a relationship between species diversity and diet. An anuran survey was conducted along riparian zones of three selected barangays of Calayagon Watershed (Guinabsan, Rizal, and Malpoc), Philippines. Extensive opportunistic methods for a total of 480 man-hours were spent traversing the area. A total of 195 individuals, consisting of seven species from four families, were recorded. Seventy-two percent of the individual species were regarded as Least concern, and 14 % were Near-threatened. …
Identification And Characterization Of Active Ingredient Eugenol From Syzygium Aromaticum (Clove Oil) Through Hplc And Its Phytochemical Analysis, Ambreen Kanwal, Saba Irshad, Nimra Akmal, Nayab Batool Rizwi
Identification And Characterization Of Active Ingredient Eugenol From Syzygium Aromaticum (Clove Oil) Through Hplc And Its Phytochemical Analysis, Ambreen Kanwal, Saba Irshad, Nimra Akmal, Nayab Batool Rizwi
Journal of Bioresource Management
Clove, Syzygium aromaticum, is one of the most valuable, ancient and premium essential oil which has been used as source of spice in agro-food industry and therapeutics for centuries. The aim of the present study was to analyze biological activities of clove oil as well as characterization of its active component Eugenol to make it worthwhile for different food and pharmaceutical formulations. Clove oil extraction was performed by Soxhlet method. Its phytochemical analysis showed the presence of carbohydrates, flavonoids, coumarins, steroids, saponnins, and tannins while proteins and leucoanthocyanins were absent in it. DPPH (2, 2-diphenyl-1-picrylhydrazyl) scavenging assay was performed which …
The Study Of Tree Biomass Calculation By Comparing Partial Harvest Method With The Allometric Equations Method, Kanlayarat Jantawong, Titinan Pothong
The Study Of Tree Biomass Calculation By Comparing Partial Harvest Method With The Allometric Equations Method, Kanlayarat Jantawong, Titinan Pothong
Journal of Bioresource Management
This study aimed to investigate the effective of partial harvest method used for tree biomass estimation. Such method was analyzed for the correlation in compare with invented allometric equations. The advantages and disadvantages of those methods were discussed. The significantly difference between estimation methods were analyzed. As a result, tree biomass calculated by the Brown’s allometric equation produced highest results, followed by the partial harvest method, Tsutsumi’s, Chave’s and Pothong’s equations respectively. The selected allometric equations showed the positive correlation with partial harvest method. The highest positive correlation was found between the partial harvest method and both equation of Chave …
A Dominant Negative Variant Of Rab5b Disrupts Maturation Of Surfactant Protein B And Surfactant Protein C, Huiyan Huang, Jiehong Pan, Ariz Mohammad, Tao Huang, Anika G Lindsey, Hyori Kim, Jian Chen, Avinash Ramu, Stephanie A Morrison, Zachary D Dawson, Alex Z Hu, Eric Tycksen, Gary A Silverman, Dustin Baldridge, Jennifer A Wambach, Stephen C. Pak, Steven L Brody, Tim Schedl, Et Al
A Dominant Negative Variant Of Rab5b Disrupts Maturation Of Surfactant Protein B And Surfactant Protein C, Huiyan Huang, Jiehong Pan, Ariz Mohammad, Tao Huang, Anika G Lindsey, Hyori Kim, Jian Chen, Avinash Ramu, Stephanie A Morrison, Zachary D Dawson, Alex Z Hu, Eric Tycksen, Gary A Silverman, Dustin Baldridge, Jennifer A Wambach, Stephen C. Pak, Steven L Brody, Tim Schedl, Et Al
Open Access Publications
Pathogenic variants in surfactant proteins SP-B and SP-C cause surfactant deficiency and interstitial lung disease. Surfactant proteins are synthesized as precursors (proSP-B, proSP-C), trafficked, and processed via a vesicular-regulated secretion pathway; however, control of vesicular trafficking events is not fully understood. Through the Undiagnosed Diseases Network, we evaluated a child with interstitial lung disease suggestive of surfactant deficiency. Variants in known surfactant dysfunction disorder genes were not found in trio exome sequencing. Instead, a de novo heterozygous variant in
Outcome Of Allogeneic Transplantation For Mature T-Cell Lymphomas: Impact Of Donor Source And Disease Characteristics, Mehdi Hamadani, Amanda F Cashen, Et Al
Outcome Of Allogeneic Transplantation For Mature T-Cell Lymphomas: Impact Of Donor Source And Disease Characteristics, Mehdi Hamadani, Amanda F Cashen, Et Al
Open Access Publications
Mature T-cell lymphomas constitute the most common indication for allogeneic hematopoietic cell transplantation (allo-HCT) of all lymphomas. Large studies evaluating contemporary outcomes of allo-HCT in mature T-cell lymphomas relative to commonly used donor sources are not available. Included in this registry study were adult patients who had undergone allo-HCT for anaplastic large cell lymphoma, angioimmunoblastic T-cell lymphoma (AITL), or peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) between 2008 and 2018. Hematopoietic cell transplantation (HCT) platforms compared were posttransplant cyclophosphamide-based haploidentical (haplo-)HCT, matched sibling donor (MSD) HCT, matched unrelated donor HCT with in vivo T-cell depletion (MUD TCD+), and matched unrelated …
Ddr1 Contributes To Kidney Inflammation And Fibrosis By Promoting The Phosphorylation Of Bcr And Stat3, Corina M. Borza, Gema Bolas, Fabian Bock, Xiuqi Zhang, Favour C Akabogu, Ming-Zhi Zhang, Mark De Caestecker, Min Yang, Haichun Yang, Ethan Lee, Leslie Gewin, Agnes B Fogo, W Hayes Mcdonald, Roy Zent, Ambra Pozzi
Ddr1 Contributes To Kidney Inflammation And Fibrosis By Promoting The Phosphorylation Of Bcr And Stat3, Corina M. Borza, Gema Bolas, Fabian Bock, Xiuqi Zhang, Favour C Akabogu, Ming-Zhi Zhang, Mark De Caestecker, Min Yang, Haichun Yang, Ethan Lee, Leslie Gewin, Agnes B Fogo, W Hayes Mcdonald, Roy Zent, Ambra Pozzi
Open Access Publications
Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen, contributes to chronic kidney disease. However, its role in acute kidney injury and subsequent development of kidney fibrosis is not clear. Thus, we performed a model of severe ischemia/reperfusion-induced acute kidney injury that progressed to kidney fibrosis in WT and Ddr1-null mice. We showed that Ddr1-null mice had reduced acute tubular injury, inflammation, and tubulointerstitial fibrosis with overall decreased renal monocyte chemoattractant protein (MCP-1) levels and STAT3 activation. We identified breakpoint cluster region (BCR) protein as a phosphorylated target of DDR1 that controls MCP-1 production in renal proximal …
Stromal Architecture Directs Early Dissemination In Pancreatic Ductal Adenocarcinoma, Arja Ray, Mackenzie K. Callaway, Nelson J. Rodríguez-Merced, Alexandra L. Crampton, Marjorie Carlson, Kenneth B. Emme, Ethan A. Ensminger, Alexander A. Kinne, Jonathan H. Schrope, Haley R. Rasmussen, Hong Jiang, David G. Denardo, David K. Wood, Paolo P. Provenzano
Stromal Architecture Directs Early Dissemination In Pancreatic Ductal Adenocarcinoma, Arja Ray, Mackenzie K. Callaway, Nelson J. Rodríguez-Merced, Alexandra L. Crampton, Marjorie Carlson, Kenneth B. Emme, Ethan A. Ensminger, Alexander A. Kinne, Jonathan H. Schrope, Haley R. Rasmussen, Hong Jiang, David G. Denardo, David K. Wood, Paolo P. Provenzano
Open Access Publications
Pancreatic ductal adenocarcinoma (PDA) is an extremely metastatic and lethal disease. Here, in both murine and human PDA, we demonstrate that extracellular matrix architecture regulates cell extrusion and subsequent invasion from intact ductal structures through tumor-associated collagen signatures (TACS). This results in early dissemination from histologically premalignant lesions and continual invasion from well-differentiated disease, and it suggests TACS as a biomarker to aid in the pathologic assessment of early disease. Furthermore, we show that pancreatitis results in invasion-conducive architectures, thus priming the stroma prior to malignant disease. Analysis in potentially novel microfluidic-derived microtissues and in vivo demonstrates decreased extrusion and …
Newsroom, Georgia Southern University
Newsroom, Georgia Southern University
Newsroom (2006-2023)
- Georgia Sothern's Public Impact Research Focus Continues to Flourish