Digital Commons Network^™

Breakthrough Medicines During The Covid-19 Pandemic Era, Eswara Naga Hanuma Kumar Ghali, Vijian Dhevan, Shravan K. Narmala, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications

No abstract provided.

Regulation Of The Double-Stranded Rna Response Through Adar1 Licenses Metaplastic Reprogramming In Gastric Epithelium, José B. Sáenz, Nancy Vargas, Charles J. Cho, Jason C. Mills

2020-Current year OA Pubs

Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA is also critical for cellular differentiation and development. The adenosine RNA deaminase, ADAR1, has been implicated as a central regulator of the dsRNA response, but how regulation of the dsRNA response might mediate cell fate during injury and whether such signaling is cell intrinsic remain unclear. Here, we show that the ADAR1-mediated response to dsRNA was dramatically induced in 2 distinct injury models of …

Helminths Of Thomomys Species (Rodentia: Geomyidae) Of Oregon, Malorri Rene Hughes

Dissertations and Theses

Although often viewed as inconsequential, parasites have significant ecological and evolutionary importance, and studying them can generate knowledge regarding their environments and their hosts. Helminths (intestinal parasites) infecting Western pocket gophers (Thomomys species) in Oregon had been documented based only on morphology prior to this study. Basing parasite identification solely on morphology is problematic because the characteristics used to identify species can be vague or similar, leading to misidentification or obscuring the true biodiversity present. Using molecular markers to verify species present not only is more reliable but also can be informative in terms of the host-parasite association. To …

Empowering Local Practitioners To Collect And Report On Anthropogenic Riverine And Marine Debris Using Inexpensive Methods In India, Katharine A. Owens, Jaya Divakaran Sarasamma, Katie Conlon, Solomon Kiruba, Alwyn Biju, Niyathi Vijay, Manikandan Subramanian, Smitha Asok Vjayamma, Ayona Jayadev, Multiple Additional Authors

Urban Studies and Planning Faculty Publications and Presentations

This article includes a review of the literature on marine debris in an Indian context and introduces a replicable, scientific, and inexpensive collection method to build capacity and inform policymakers. We share baseline data resulting from ten cleanups using these methods in India. This method was introduced in a 2019 workshop to train Indian researchers, leading to local-led collections in three states and two Union Territories (8 beaches, 2 riversides) yielding 33,474 individual pieces of debris weighing a total of 599.15 kg. Plastic was the most frequently found material at all ten collection sites, comprising from 45% to 89% of …

Regulation Of The Double-Stranded Rna Response Through Adar1 Licenses Metaplastic Reprogramming In Gastric Epithelium, José B Sáenz, Nancy Vargas, Charles J Cho, Jason C Mills

Faculty, Staff and Students Publications

Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA is also critical for cellular differentiation and development. The adenosine RNA deaminase, ADAR1, has been implicated as a central regulator of the dsRNA response, but how regulation of the dsRNA response might mediate cell fate during injury and whether such signaling is cell intrinsic remain unclear. Here, we show that the ADAR1-mediated response to dsRNA was dramatically induced in 2 distinct injury models of …

Cryo-Et Of Toxoplasma Parasites Gives Subnanometer Insight Into Tubulin-Based Structures, Stella Y Sun, Li-Av Segev-Zarko, Muyuan Chen, Grigore D Pintilie, Michael F Schmid, Steven J Ludtke, John C Boothroyd, Wah Chiu

Faculty, Staff and Students Publications

Tubulin is a conserved protein that polymerizes into different forms of filamentous structures in Toxoplasma gondii, an obligate intracellular parasite in the phylum Apicomplexa. Two key tubulin-containing cytoskeletal components are subpellicular microtubules (SPMTs) and conoid fibrils (CFs). The SPMTs help maintain shape and gliding motility, while the CFs are implicated in invasion. Here, we use cryogenic electron tomography to determine the molecular structures of the SPMTs and CFs in vitrified intact and detergent-extracted parasites. Subvolume densities from detergent-extracted parasites yielded averaged density maps at subnanometer resolutions, and these were related back to their architecture in situ. An intralumenal spiral …

Myocardial Rev-Erb-Mediated Diurnal Metabolic Rhythm And Obesity Paradox, Shiyang Song, Chih-Liang Tien, Hao Cui, Paul Basil, Ningxia Zhu, Yingyun Gong, Wenbo Li, Hui Li, Qiying Fan, Jong Min Choi, Weijia Luo, Yanfeng Xue, Rui Cao, Wenjun Zhou, Andrea R Ortiz, Brittany Stork, Vatsala Mundra, Nagireddy Putluri, Brian York, Maoping Chu, Jiang Chang, Sung Yun Jung, Liang Xie, Jiangping Song, Lilei Zhang, Zheng Sun

Faculty, Staff and Students Publications

BACKGROUND: The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated with the progression of any naturally occurring human heart diseases. Obesity paradox refers to the seemingly protective role of obesity for heart failure, but the mechanism is unclear.

METHODS: We generated mouse lines with cardiac-specific Rev-erbα/β knockout (KO), characterized cardiac phenotype, conducted multi-omics (RNA-sequencing, chromatin immunoprecipitation sequencing, proteomics, and metabolomics) …

Differences In Research On Post-Traumatic Stress Disorder: How Trauma-Type And Sex Contribute To The Published Research, Jessica Anzalone, Sharon Ramos-Goyette, Marissa Morganelli, Merideth Krevosky

Journal of International Women's Studies

There is a pervasive and comprehensive history of sexism in the pursuit of scientific truth, extending back beyond the days of “hysteria” and continuing still. Herein, we discuss a disparity in scientific research on a disorder thought to affect less than 8% of the adult population in the USA with the number of women diagnosed with the disorder estimated to be two to three times higher than that of men. While post-traumatic stress disorder (PTSD) is more likely to be experienced by women, we find that the overwhelming majority of published scientific literature on PTSD involves male combat veterans. For …

Gender Inequality Affecting Women’S Career Progression In Malaysia, Krishna Moorthy, Nik Mohamad Zaki Nik Salleh, Loh Chun T'Ing, Lai Pui Ling, Diong Min Yeng, Lau Jia Ning, Lee Jer Sin, Lee Pui Mun

Journal of International Women's Studies

The objective of this research is to assess whether gender inequality affects women’s career progression in Malaysia. The study examines the relationship between patriarchy, gender stereotypes, organisational cultural factors, family factors, and individual factors with women’s career progression. The study has adopted the Glass Ceiling Theory and feminist theory. A total of 250 questionnaires were collected from women employees working in Malaysia. The study revealed that patriarchy, organisational cultural factors, and family factors had a significant relationship with women’s career progression while gender stereotypes and individual factors had no significant relationship with women’s career progression. The findings of this study …

He Said, She Said: A Critical Content Analysis Of Sexist Language Used In Disney’S The Little Mermaid (1989) And Mulan (1998), Shakira Begum

Journal of International Women's Studies

This study looks at how Disney princess films perpetuate sexist tropes through language. By focusing on both feminism and linguistics, it uses an interdisciplinary approach underpinned by data analysis and media criticism. This paper uses a content analysis study of The Little Mermaid (1989) and Mulan (1998) to look at Disney’s role in shaping representations of women, and how this representation has shifted within the decade of the release of these two films. This paper answers the question: in what ways does language in media perpetuate sexist tropes; more specifically, how has the language of male characters in media perpetuated …

Florence Nightingale, The Colossus: Was She A Feminist?, Susan Hogan

Journal of International Women's Studies

Nightingale displayed a particular brand of feminism that reflected the circumstances of her era. The question of women’s involvement in healthcare is addressed through an analysis of Nightingale’s most famous work, Notes on Nursing. What it is, and what it is not (1859/60). Then other key works are scrutinised with reference to ideas about female involvement in healthcare and how she addresses the position of women in general terms. Nightingale’s works, Notes on Hospitals (1859); Suggestions for Thought to the Searchers after Truth among the Artisans of England (1860); Introductory Notes on Lying-In Institutions (1871) are focussed upon illustrating her …

Mobilizing Masculinity: Conscription, Gender, And Community Wellbeing In Lithuania, Frances Harrison

Journal of International Women's Studies

In the wake of Russia’s 2014 annexation of Crimea, the conscription law in Lithuania has been reinstated for men, and partnerships with Western security structures reinforced. While young men are otherwise mobilizing to navigate socioeconomic uncertainty to improve their livelihoods under depressed conditions, the revitalization of mandatory military service increasingly polices individual experiences of wellbeing in gendered and nationalistic ways. Drawing from feminist analyses of securitization and from theories of gender performativity, this article examines how the Lithuanian State, together with the Lithuanian Armed Forces (LAF), mobilize masculinity and the construction of militarized identities in order to shape public support …

Women’S Sexual Health Rights In Egypt, Mira Ayman

Journal of International Women's Studies

The Egyptian youth makes up 60% of the Egyptian population. Accessing proper reproductive health information still continues to be one of the main issues that the youth in Egypt faces, especially the unmarried fragment. This situation is largely due to religious conservatism. Because this issue remains a taboo, information on STI’s, FGM, contraception, sexual consent and other sexual health-related issues remain very limited. Private hospitals and clinics in Egypt do not offer youth-friendly services and only focuses on activities that would generate income (antenatal care and delivery). The lack of knowledge leads curious young adults to refer to online sources …

Workshop 1 - Omics Data Workshop, Ali Rahnavard, Himel Mallick

SDSU Data Science Symposium

Participants will gain hands-on experience with these analyses using tools for pattern discovery in multi-omics. Interspersed with lecture content, attendees will work through multi-omics analysis exercises with real data. Participants are strongly encouraged to bring their own data and study examples for application. Open to computational biologists, bioinformaticians, principal investigators, and their research teams including advanced Ph.D. students. Basic familiarity with multi-omics upstream bioinformatics tools are recommended. Beginner-level familiarity with R is required. Methodological advancements paired with measured multi-omics data using high-throughput technologies enable capturing comprehensive snapshots of biological activities. In particular, low-cost, culture-independent omics profiling has made metagenomics, metabolomics, …

Workshop 2 - Intro To Microsoft Power Bi, Negassi Tesfay

SDSU Data Science Symposium

PowerBI is an interactive data visualization and reporting tool that is used in businesses. In this workshop, you will learn how to apply Power BI for best practices that are in line with current businesses and technical requirements for extracting, loading, modeling, visualizing, and analyzing data.

2022 Sdsu Data Science Symposium Presentation Abstracts, Department Of Mathematics & Statistics

SDSU Data Science Symposium

This document contains abstracts for presentations and posters 2022 SDSU Data Science Symposium.

2022 Sdsu Data Science Symposium Speaker Information, Department Of Mathematics & Statistics

SDSU Data Science Symposium

This document provides information on the speakers and workshop instructors for the 2022 SDSU Data Science Symposium.

Effect Of Varying Reynolds Number On The Aerodynamic Design Of Lifting Surfaces, Seshan Jayapregasham

AIAA Southeastern Regional Student Conference

The design of an airfoil section is a critical part of the performance of a lifting surface. Historically, airfoil designs have evolved based on the Reynolds number which encompasses the scale and the fluid momentum effects on airfoil behavior. From insect flight at low Reynolds numbers to supersonic jets at high Reynolds numbers, this review highlights the varying airfoil designs that maximize performance of the lifting surface. As humans move towards the exploration of planets using rotary winged vehicles, airfoil designs must accommodate for unexplored flow environments. Designs are discussed for compressible ultra-low Reynolds number flows in the Martian environment …

Climate Change, Armed Conflicts And Resilience, Mariagrazia D'Angeli, Giovanni Marin, Elena Paglialunga

Fondazione Eni Enrico Mattei Working Papers

In recent years, there has been rapid development of the literature linking climate change and armed conflicts. Although no conclusionary evidence has been found of a direct link between climate change and armed conflicts, still climate change has been addressed as an important trigger, exacerbating underlying social, economic and institutional conditions and thus resulting in higher risk and magnitude of violent activities. In this context, while more research is needed to further disentangle how climatic changes combine with socio-economic and institutional elements to induce conflicts, an important pathway to be explored is the role that building resilience can play in …

A Rationale For Integrating Writing Into Secondary Content Area Classrooms: Perspectives From Teachers Who Experience The Benefits Of Integrating Writing Frequently, Hannah Carter, Dianna Townsend

Literacy, Language and Culture Faculty Publications and Presentations

Teachers navigate ongoing accountability pressures that target writing in each content area, yet little is understood about their experiences with or their rationales for integrating writing into content area lessons. While previous research describes writing in U.S. secondary classrooms and explains barriers to writing integration, this study investigates teacher decision making to determine why teachers in various content areas are integrating writing. Using a multicase study design, we explored teacher reflections to discern the reasons why teachers chose to integrate writing frequently. Four teachers, one from each primary content area (mathematics, English language arts, science, social studies), reflected on their …

Male And Female Interactions: A Multimodal Analysis Of Shonen Manga, Alexandria Perez

The Montana English Journal

A qualitative multimodal content analysis of popular manga examined how female and male character interactions represented gender roles. An analytical tool was developed using multimodal, semiotic, social semiotic, gender, and feminist theories to understand representations of males and females in this popular media. This study showed that traditional gender norms are still present in manga, but there are some that break stereotypes. Also, in using both textual and visual elements to interpret multimodal texts, understanding of character interactions were enhanced because the intermodal interactions created new meaning. Implications suggest positive outlooks for manga being used as an educational tool by …

Functional Antagonism Of Wri1 And Tcp20 Modulates Gh3.3 Expression To Maintain Auxin Homeostasis In Roots, Que Kong, Pui Man Low, Audrey R. Q. Lim, Yuzhou Yang, Ling Yuan, Wei Ma

Kentucky Tobacco Research and Development Center Faculty Publications

Auxin is a well-studied phytohormone, vital for diverse plant developmental processes. The GH3 genes are one of the major auxin responsive genes, whose expression changes lead to modulation of plant development and auxin homeostasis. However, the transcriptional regulation of these GH3 genes remains largely unknown. WRI1 is an essential transcriptional regulator governing plant fatty acid biosynthesis. Recently, we identified that the expression of GH3.3 is increased in the roots of wri1-1 mutant. Nevertheless, in this study we found that AtWRI1 did not activate or repress the promoter of GH3.3 (proGH3.3) despite of its binding to proGH3.3. Cross-family …

Fort Hays State University Faculty Senate Minutes, February 7, 2022, Fhsu Faculty Senate

Faculty Senate

No abstract provided.

Qbi Seminar | How Cells Measure Length, Feb 8, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Prostacyclin Promotes Degenerative Pathology In A Model Of Alzheimer’S Disease, Tasha R. Womack, Craig T. Vollert, Odochi Ohia-Nwoko, Monika Schmitt, Saghi Montazari, Tina L. Beckett, David Mayerich, M. Paul Murphy, Jason L. Eriksen

Molecular and Cellular Biochemistry Faculty Publications

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is the most common form of dementia in aged populations. A substantial amount of data demonstrates that chronic neuroinflammation can accelerate neurodegenerative pathologies. In AD, chronic neuroinflammation results in the upregulation of cyclooxygenase and increased production of prostaglandin H2, a precursor for many vasoactive prostanoids. While it is well-established that many prostaglandins can modulate the progression of neurodegenerative disorders, the role of prostacyclin (PGI2) in the brain is poorly understood. We have conducted studies to assess the effect of elevated prostacyclin biosynthesis in a mouse model of AD. Upregulated prostacyclin expression …

Utilizing Nasa-Funded Biotechnology To Improve Resource Management On Earth And In Space, Tyler Wallentine

Research on Capitol Hill

USU senior Tyler is a Peak Summer Research Fellow studying biological engineering. Nitrogen, essential in soil fertilizer for crops, is produced traditionally in a way that uses natural gas and produces CO2. Tyler’s project has been to apply methods developed by NASA for astronauts to conserve and reuse resources to create nitrogen using wastewater and bacteria. Using this method would not only take advantage of waste we already have, but doesn’t produce CO2 and contribute to pollution. Tyler hopes to become a chemical engineer in the space industry and credits his undergraduate research experience. “There’s something about having to obtain …

To Better Engage Students, Instructors Should Create Lab Exercises With Real-World Examples., Autumn Kelsch

Research on Capitol Hill

USU senior Autumn studies biology here in Logan and led and funded this project herself through a student grant. ‘Elementary Microbiology’ is a required course for many medical fields, and traditionally relies on several pre-determined research projects in class. However, educators suggest that students gain more from open-ended projects where the answer is unknown and the students’ findings contribute to our knowledge on the subject. When Autumn was hired as a teaching assistant for this course at USU, she developed and created a project where students look for bacteria in soil samples that may help fight infections. She now hopes …

What Drug Candidates Exist For Treating Covid-19 Variants?, Kolton Hauck

Research on Capitol Hill

USU senior Kolton studies biological engineering and led this project with funding from a student grant. Kolton’s project has been mapping out all possible protein interactions from known SARS-CoV-2 variants and identifying possible drug treatments. Viruses function through these interactions between their proteins and the host cell’s proteins, and this project is especially valuable because the candidates identified are predicted to help treat all known variants, making them more likely to be effective against future mutations.Kolton’s interest in biological research stems from his own experience managing a genetic health disorder. Past medical research greatly benefited him, and he sees his …

Test-Driving The Next Generation Of Crispr Gene Editing, Olivia Gornichec, Kailey Mayer

Research on Capitol Hill

USU team Kailey, recent graduate of animal science, and Olivia, senior in biochemistry, have led and funded this project through a student grant. CRISPR has been making waves in the scientific community for its potential to help us edit genomes. However, that is just one of the known types of CRISPR, and other types aren’t in forms that are accessible to study. Kailey and Olivia have successfully cloned Type IV-B into a plasmid that can now be used to perform further research into what this system does. The two students never expected that, as undergrads, they would make a foundation-level …

Understanding The Decline In Successful Cattle Pregnancies, Andre Tu Nguyen

Research on Capitol Hill

USU junior Andre, a local Loganer, studies computer science and biology.He has been working in an animal science lab. Over time, we have seen a decline in successful dairy cattle pregnancies. This is a huge cause for concern for Utah, with milk sales at an estimated value of $405 million in 2020. Andre’s work has been in studying a certain protein in pregnant cattle; now that he has determined there is a decrease in this protein over the course of the pregnancy, he hopes to see whether that might impact its viability. Andre got involved in research in a high …