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Flowering By Dioecious Rhamnus Ilicifolia (Rhamnaceae) And Pollen Transport To Female Flowers By Flies And Bees, William D. Wiesenborn

Western North American Naturalist

Rhamnus ilicifolia (Rhamnaceae) is a large shrub found in a range of habitats from southern Oregon south to Baja California and east into Arizona. During spring, the plant produces clusters of unisexual flowers, each with a 5–6-mm-diameter, open perianth of green or yellowish-green sepals. I investigated the pollination of R. ilicifolia in western Arizona during 27 April to 21 May 2020 by examining the distribution and phenology of male and female flowers on shrubs, collecting insects from female flowers, and determining the proportions of conspecific pollen on insects to estimate floral constancy. Shrubs were dioecious, and individual male and female …

Decline Of The Northern Long-Eared Myotis (Myotis Septentrionalis) In The Eastern Great Plains After The Arrival Of White-Nose Syndrome, Jeremy A. White, Patricia W. Freeman, Madelene I. Shehan, Cliff A. Lemen

Western North American Naturalist

The northern long-eared myotis (Myotis septentrionalis) has declined sharply in the eastern United States due to the disease white-nose syndrome (WNS), which is caused by the fungus Pseudogymnoascus destructans (Pd). However, less is known about the species’ status in the central and western parts of its range where WNS has arrived more recently. Here we report the timing of the arrival of Pd and WNS to eastern Nebraska and examine acoustic and capture data of M. septentrionalis to determine the initial impact of the disease on this species. We sampled bats for the presence of Pd …

Effective Therapy For Aml With Runx1 Mutation By Cotreatment With Inhibitors Of Protein Translation And Bcl2, Christopher P Mill, Warren Fiskus, Courtney D Dinardo, Christine Birdwell, John A Davis, Tapan M Kadia, Koichi Takahashi, Nicholas Short, Naval Daver, Maro Ohanian, Gautam Borthakur, Steven M Kornblau, Michael R Green, Yuan Qi, Xiaoping Su, Joseph D Khoury, Kapil N Bhalla

Faculty, Staff and Student Publications

The majority of RUNX1 mutations in acute myeloid leukemia (AML) are missense or deletion-truncation and behave as loss-of-function mutations. Following standard therapy, AML patients expressing mtRUNX1 exhibit inferior clinical outcome than those without mutant RUNX1. Studies presented here demonstrate that as compared with AML cells lacking mtRUNX1, their isogenic counterparts harboring mtRUNX1 display impaired ribosomal biogenesis and differentiation, as well as exhibit reduced levels of wild-type RUNX1, PU.1, and c-Myc. Compared with AML cells with only wild-type RUNX1, AML cells expressing mtRUNX1 were also more sensitive to the protein translation inhibitor homoharringtonine (omacetaxine) and BCL2 inhibitor venetoclax. Homoharringtonine treatment repressed …

Investigating The Behavior And Personality Structure Of The Aldabra Tortoise During Human Interactions And Training Events, Pastorino G Quintavalle, Vanessa Smith, Massimo Faustini, Eleonora Bonacina, Davide Guadagnini, Roberto Robbiati, Alice Cavalleri, James Edward Brereton, Richard Preziosi

School of Biological and Marine Sciences

Human–animal interaction (HAI) can be valuable for captive animals, and many zoo-housed species benefit from interactions with their keepers. There is also an increasing body of evidence that some animal species possess personalities that are temporally consistent. However, the majority of zoo research, particularly on personality and HAI, traditionally has focused on mammals, and there are comparatively fewer studies on reptiles. Research was undertaken at the Faunistic Park Le Cornelle, Italy, to investigate the effects of approach tests and food interaction events on 5 male and 5 female Aldabra tortoise (Aldrabrachelys gigantea) behavior. During human–tortoise interactions, continuous focal sampling of …

On The Photostability Of Cyanuric Acid And Its Candidature As A Prebiotic Nucleobase, Luis A. Ortiz-Rodríguez, Sean J. Hoehn, Carlos E. Crespo-Hernández

Faculty Scholarship

Cyanuric acid is a triazine derivative that has been identified from reactions performed under prebiotic conditions and has been proposed as a prospective precursor of ancestral RNA. For cyanuric acid to have played a key role during the prebiotic era, it would have needed to survive the harsh electromagnetic radiation conditions reaching the Earth’s surface during prebiotic times (≥200 nm). Therefore, the photostability of cyanuric acid would have been crucial for its accumulation during the prebiotic era. To evaluate the putative photostability of cyanuric acid in water, in this contribution, we employed density functional theory (DFT) and its time-dependent variant …

Three-Week Old Pigs Are Not Susceptible To Productive Infection With Sars-Cov-2, Elaine Haddock, Julie Callison, Stephanie N. Seifert, Atsushi Okumura, Tsing Lee Tang-Huau, Shanna S. Leventhal, Matthew C. Lewis, Jamie Lovaglio, Patrick W. Hanley, Carl Shaia, David W. Hawman, Vincent J. Munster, Michael A. Jarvis, Juergen A. Richt, Heinz Feldmann

School of Biomedical Sciences

As the COVID-19 pandemic moves into its third year, there remains a need for additional animal models better recapitulating severe COVID to study SARS-CoV-2 pathogenesis and develop countermeasures, especially treatment options. Pigs are known intermediate hosts for many viruses with zoonotic potential and are susceptible to infection with alpha, beta and delta genera of coronaviruses. Herein, we infected young (3 weeks of age) pigs with SARS-CoV-2 using a combination of respiratory and parenteral inoculation routes. Pigs did not develop clinical disease, nor macroscopic or microscopic pathologic lesions upon SARS-CoV-2 infection. Despite occasional low levels of SARS-CoV-2 genomic RNA in the …

Preservation Of Library Materials: A Case Of A Public Library Within The Accra Metropolitan Area Of Ghana, Deborah Nyamewaah Amankwah Mrs., Albert Paa Kojo Ebi Bilson Mr., Gloria Atisoe Ms.

Library Philosophy and Practice (e-journal)

Preservation is an important component of the library as it is designed to prolong the lifespan of library collections in order to provide access to users. The study was achieved through different reviews on literature in relation to library preservation. Globally different kinds of literature have been reviewed on the preservation of library materials and specifically narrowed to Ghana. The purpose of the study was to review the literature on the prospects and challenges of library materials in Ghana. The study further sought to find out the benefits of preserving library materials and identification of the internal and external factors …

Single-Agent Mosunetuzumab Shows Durable Complete Responses In Patients With Relapsed Or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study, Lihua E Budde, Nancy L Bartlett, Et Al

2020-Current year OA Pubs

PURPOSE: Mosunetuzumab is a bispecific antibody targeting CD20 and CD3 that redirects T cells to engage and eliminate malignant B cells and is being developed for relapsed or refractory (R/R) B-cell non-Hodgkin lymphomas (B-NHLs).

METHODS: This first-in-human trial (ClinicalTrials.gov identifier: NCT02500407) evaluated the safety and tolerability and efficacy of mosunetuzumab in patients with R/R B-NHL and established the recommended phase II dose. Data from dose escalation are presented. Single-agent mosunetuzumab was administered intravenously in 3-week cycles, at full dose in cycle 1 day 1 (group A) or with ascending (step-up) doses during cycle 1 on days 1, 8, and 15 …

Innovative Approaches To Analysing Carbon Sequestration As A Mitigation Strategy In Tropical Pasture Landscapes In Two Emblematic Contexts, The Amazon And The West African Sahel, V. Blanfort, R. Pocard-Chapuis, J. Vayssières, M. Vignes, M. H. Assouma, B. Hubert, A. Ickowicz, S. Fontaine

IGC Proceedings (1977-2023)

The relationship between ruminant production systems and climate change is complex. As a major contributor to greenhouse gas (GHG) emissions, the sector has been the subject of considerable controversy, with particularly severe criticism in the 2000s. However, ten years ago, the attitude towards grazing lands began to change. Their efficient use of non-renewable energy and their contribution to carbon (C) sequestration were considered as key factors in the new environmental challenge. The reality of this mitigation potential was recently called into question once again in the global agriculture and climate change debate, including that of sequestration in the soil where …

Elevated Co2 And Extreme Climatic Events Modify Nitrogen Content And Ruminal Protein Digestion Of Temperate Grassland, V. Niderkorn, C. Picon-Cochard

IGC Proceedings (1977-2023)

This study was aimed at analyzing changes in nitrogen (N) content and in vitro protein rumen digestion of an upland grassland exposed to climate changes in controlled conditions. Monoliths of grassland were inserted in 12 macrocosms in which climatic conditions for the 2050s were simulated (i.e., +2.3°C and 33 mm less precipitation compared to the current climatic conditions). Six of them were subjected to ambient CO₂ (390 ppm) while the other six were subjected to elevated CO₂ (520 ppm). After four months, an extreme climatic event (ECE) consisting of four weeks of reducted precipitation (-50%) followed by two …

Effects Of Climate Variability On Wild Edible Plant Products: A Coping Strategy Applied By Pastoralists Of Northern Kenya, A. W. Kagunyu, J. W. Wanjohi

IGC Proceedings (1977-2023)

Drought which is a manifestation of climate variability has become a perennial problem in Kenya with chronic vulnerability being concentrated in Arid and Semi-Arid lands (ASALs). Traditionally, pastoralists have used wild edible plant products namely; fruits, vegetables and seeds as a coping strategy while faced by climate related calamities. However, recent studies have shown that pastoralists’ traditional coping strategies have become weak as a result of recurrent droughts. The overall objective of this study was to investigate the effects of climate variability on wild edible plant products. This study applied; household interviews (n=400), focus group discussions and key informant interviews …

Drought Mitigation In Bundelkahand Grassland Ecosystem For Improving Livelihood Of Farming Community-A Case Study, N. S. Pasricha, P. K. Ghosh

IGC Proceedings (1977-2023)

Bundelkhand grassland ecosystem (23º20´ and 26°20´N latitude and 78°20´ and 81°40´E longitude) is an undulating rain fed region (annual rain fall, 768-1087 mm) spread over an area of 7.08 m ha in central India in the states of Madhya Pradesh and Uttar Pradesh. This region has to support 16 million human and 8.5 million animal populations. Area is prone to surface run off losses, severe soil erosion and increasingly more drought events, leading to only mono-cropping. Lively-hood of the people, which is mainly the live-stock rearing and marginal agriculture, is at stake. In-situ conservation of rain water, forage management, …

The Story Of Winston Kapoor Or The Story Of All Men And People Of Colour: A Case Of Tragic Pessimism Of The Modern Times, Ripon Singh

Budding Writers Contest 2021

No abstract provided.

We Are ... Marshall, February 9, 2022, Office Of Marshall University Communications

We Are ... Marshall: the Newsletter for Marshall University 1999-2023

No abstract provided.

Single-Cell Analysis Of Human Glioma And Immune Cells Identifies S100a4 As An Immunotherapy Target., Nourhan Abdelfattah, Parveen Kumar, Caiyi Wang, Jia-Shiun Leu, William F Flynn, Ruli Gao, David S Baskin, Kumar Pichumani, Omkar B Ijare, Stephanie L Wood, Suzanne Z Powell, David L Haviland, Brittany C Parker Kerrigan, Frederick F Lang, Sujit S Prabhu, Kristin M Huntoon, Wen Jiang, Betty Y S Kim, Joshy George, Kyuson Yun

Faculty Research 2022

A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986 human glioma, immune, and other stromal cells at the single cell level. In doing so, we discover extensive spatial and molecular heterogeneity in immune infiltrates. We identify molecular signatures for nine distinct myeloid cell subtypes, of which five are independent prognostic indicators of glioma patient survival. Furthermore, we identify S100A4 as a regulator of immune suppressive T and myeloid cells in GBM and demonstrate …

Science Café Goes ‘Globetrotting For Violets’ With Harvey Ballard On Feb. 15, Ohio University College Of Arts & Sciences

All Forum Articles

No abstract provided.

Mark-Recapture Study And Habitat Assessment For The Northern Metalmark Butterfly, Calephelis Borealis (Lepidoptera: Riodinidae), Weston J. Henry, Kristian S. Omland, Henry Frye, Wagner L. David

EEB Articles

Background: The northern metalmark (Calephelis borealis), is an exceedingly local, globally rare butterfly that is declining across the Midwestern and Northeastern USA. The principal stressors driving colony losses include afforestation and invasive plants that crowd out its larval hostplant (Packera ovata) and nectar resources.

Aims/Methods: To better understand its declines and guide restoration efforts, we 1) performed a mark-recapture study in Connecticut to document population trends where we were actively managing vegetation; 2) conducted a range-wide survey for evidence of phylogeographic structure, using cytochrome oxidase (CO1); 3) investigated abundance determinants of its larval foodplant, Packera ovata …

The Current - Volume 32 Issue 19, Nova Southeastern University

Student Newspapers

No abstract provided.

Invisible Trash: Emerging Contaminants In Streams And Rivers, Megan Fork

Sustainability Research & Practice Seminar Presentations

Professor Megan Fork, Biology - Invisible Trash: Emerging Contaminants in Streams and Rivers

Tactical Masters Athletes: Bmi Index Classifications, Marc Keefer, Joe Walsh, Kent Adams, Mike Climstein, Chad Harris, Mark Debeliso

All Faculty Scholarship for the College of Education and Professional Studies

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines (n = 402, male, …

The Lumberjack, February 09, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

Differences In Clinical And Functional Outcomes Between Osteochondral Allograft Transplantation And Autologous Chondrocyte Implantation For The Treatment Of Focal Articular Cartilage Defects, John R Matthews, Joseph Brutico, Daniel Abraham, Jeremy Heard, Bradford Tucker, Fotios Tjoumakaris, Kevin Freedman

Rothman Institute Papers

Background: Articular cartilage pathology can result from a spectrum of origins, including trauma, osteochondritis dissecans, avascular necrosis, or degenerative joint disease.

Purpose: To compare the differences in clinical and patient-reported outcomes after autologous chondrocyte implantation (ACI) versus osteochondral allograft transplantation (OCA) in patients with focal articular cartilage defects without underlying bone loss.

Study design: Cohort study; Level of evidence, 3.

Methods: A retrospective review identified patients who underwent ACI or OCA between 2008 and 2016 for isolated grades 3 and 4 articular cartilage defects without underlying bone loss. Outcome measures included the Knee injury and Osteoarthritis Outcome Score for Joint …

Efficacy Of Softener For Enhancing Fatigue And Low-Temperature Performance Of Asphalt Binders With High Rap, Sumon Roy

Student Theses and Dissertations

The use of a higher percentage of reclaimed asphalt pavement (RAP) in asphalt concrete can lead to developing premature failure of asphalt pavements due to fatigue and/or low-temperature cracking. The incorporation of softening agents in asphalt binders can resolve these problems and enhance pavement durability. This study aims to evaluate the effectiveness of waste-based softening agents for enhancing the properties of asphalt mixes with high RAP contents. Waste cooking oil (WCO), and engine bottom oil (EBO) along with a commercial rejuvenator were investigated in this study. Three types of Performance Grade (PG) binders, each collected from two different sources, used …

Functional Maintenance Of Differentiated Embryoid Bodies In Microfluidic Systems: A Platform For Personalized Medicine, Umut A. Gurkan

Faculty Scholarship

Hormone replacement therapies have become important for treating diseases such as premature ovarian failure or menopausal complications. The clinical use of bioidentical hormones might significantly reduce some of the potential risks reportedly associated with the use of synthetic hormones. In the present study, we demonstrate the utility and advantage of a microfluidic chip culture system to enhance the development of personalized, on-demand, treatment modules using embryoid bodies (EBs). Functional EBs cultured on microfluidic chips represent a platform for personalized, patient-specific treatment cassettes that can be cryopreserved until required for treatment. We assessed the viability, differentiation, and functionality of EBs cultured …

Aloin Isoforms (A And B) Selectively Inhibits Proteolytic And Deubiquitinating Activity Of Papain Like Protease (Plpro) Of Sars-Cov-2 In Vitro., Devin S M Lewis, Joanna Ho, Savannah Wills, Anasha Kawall, Avini Sharma, Krishna Chavada, Maximilian C C J C Ebert, Stefania Evoli, Ajay Singh, Srujana Rayalam, Vicky Mody, Shashidharamurthy Taval

PCOM Scholarly Works

The most common host entry point of human adapted coronaviruses (CoV) including SARS-CoV-2 is through the initial colonization in the nostril and mouth region which is responsible for spread of the infection. Most recent studies suggest that the commercially available oral and nasal rinse products are effective in inhibiting the viral replication. However, the anti-viral mechanism of the active ingredients present in the oral rinses have not been studied. In the present study, we have assessed in vitro enzymatic inhibitory activity of active ingredients in the oral mouth rinse products: aloin A and B, chlorhexidine, eucalyptol, hexetidine, menthol, triclosan, methyl …

Tactical Masters Athletes: Bmi Index Classifications, Marc Keefer, Joe Walsh, Kent Adams, Mike Climstein, Chad Harris, Mark Debeliso

Kinesiology Faculty Publications and Presentations

Understanding the nexus between aging, physical activity, and obesity has been a source of ongoing investigation. A considerable amount of research has focused on Masters athletes in this regard, suggesting a beneficial relationship between Masters sport participation and a healthy body mass index (BMI). Some consider Active Duty military personnel as tactical athletes. As such, it is of interest to determine if aging Active Duty military personnel (or Masters Tactical Athletes) might have a similar BMI as other Masters athletes (MA). As such, this investigation examined previously recorded data of Active Duty Enlisted United States Marines ( = 402, male, …

Auxin/Cytokinin Antagonistic Control Of The Shoot/Root Growth Ratio And Its Relevance For Adaptation To Drought And Nutrient Deficiency Stresses, Jasmina Kurepa, Jan A. Smalle

Plant and Soil Sciences Faculty Publications

The hormones auxin and cytokinin regulate numerous aspects of plant development and often act as an antagonistic hormone pair. One of the more striking examples of the auxin/cytokinin antagonism involves regulation of the shoot/root growth ratio in which cytokinin promotes shoot and inhibits root growth, whereas auxin does the opposite. Control of the shoot/root growth ratio is essential for the survival of terrestrial plants because it allows growth adaptations to water and mineral nutrient availability in the soil. Because a decrease in shoot growth combined with an increase in root growth leads to survival under drought stress and nutrient limiting …

Hpg80 (Circulating Progastrin), A Novel Blood-Based Biomarker For Detection Of Poorly Differentiated Neuroendocrine Carcinoma And Well Differentiated Neuroendocrine Tumors, Aman Chauhan, Alexandre Prieur, Jill Kolesar, Susanne Arnold, Léa Payen, Younes Mahi, Berengere Vire, Madison Sands, B. Mark Evers, Dominique Joubert, Lowell Anthony

Markey Cancer Center Faculty Publications

Current blood-based biomarkers for neuroendocrine neoplasms (NENs) lack both sensitivity and specificity. Human circulating progastrin (hPG₈₀) is a novel biomarker that can be easily measured in plasma by ELISA. This study is the first to examine hPG₈₀ in NENs. Plasma hPG₈₀ was quantified from 95 stage IV NEN patients, using DxPG₈₀ technology (ECS Progastrin, Switzerland) and compared with hPG₈₀ concentrations in two cohorts of healthy donor controls aged 50–80 (n = 252) and 18–25 (n = 137). Median hPG₈₀ in NENs patients was 5.54 pM compared to 1.5 pM for the …

Diet Quality And Dietary Inflammatory Index Score Among Women’S Cancer Survivors, Sibylle Kranz, Faten Hasan, Erin Kennedy, Jamie Zoellner, Kristin A. Guertin, Nitin Shivappa Mbbs, Mph, Ph.D., James R. Hébert, Roger Anderson, Wendy Cohn

Faculty Publications

The purpose of this study was to investigate Healthy Eating Index 2015 (HEI-2015) and Energy-Adjusted Dietary Inflammatory Index (E-DIITM) scores in women's cancer survivors and to examine socio-economic (SES) characteristics associated with these two diet indices. In this cross-sectional study, survivors of women's cancers completed a demographic questionnaire and up to three 24-h dietary recalls. HEI-2015 and E-DII scores were calculated from average intakes. One-way ANOVA was used to examine the association of various demographic factors on HEI-2015 and E-DII scores. Pearson Correlation was used to calculate the correlation between the two scores. The average HEI-2015 score was 55.0 +/- …

What Tourists Want, A Sustainable Paradise, Catherine Linnes, Jerome Agrusa, Giulio Ronzoni, Joseph Lema

Hospitality Faculty Research

The increasing complexity of tourism and sustainability offers opportunities and challenges among diverse stakeholder perspectives. The need for sustainable and nature-based approaches exists throughout the growing body of literature from among a number of dimensions and measures. One of the overarching goals of the paper is to examine whether tourists will choose a destination or hotel that is actively working to improve the environment while examining how Hawaii’s tourism is nature-based as well as other measures of sustainability while enjoying a slice of paradise in the Hawaiian Islands. This study explores tourism sustainability concerns in Hawaii, such as the influence …