Digital Commons Network^™

Beyond Immunosuppression: New Horizons In Kidney Allograft Tolerance And Survival, Opas Traitanon

Asian Medical Journal and Alternative Medicine

No abstract provided.

Twenty Years' Experience Of Congenital Heart Disease Characterization In Thammasat University Hospital, Thanavit Manakijjongkol, Boonchu Sirichongkolthong

Asian Medical Journal and Alternative Medicine

Introduction: Congenital heart disease (CHD) is a leading cause of pediatric mortality globally, including in Thailand. Understanding CHD types and severity is crucial for epidemiology and patient care.

Objective: This study aimed to examine demographic data, types, and severity of CHD in patients at Thammasat University Hospital from 2001 to 2020, and to compare CHD types between 2001–2010 and 2011–2020.

Methods: A retrospective review collected data from pediatric patients (aged 15 years or younger) from 2001 to 2020, based on echocardiography and medical records. Demographic information, diagnosis, classification, and CHD severity were analyzed using counts and percentages. Comparisons of severity …

Educational Transformation Through Aligning With Oman Vision 2040, Rabie A. Ramadan

Journal of Arts and Social Sciences

This paper investigates the role of Artificial Intelligence (AI) in revolutionizing the education sector under the Oman 2040 vision. The vision aspires to economic sustainability, and education is a cornerstone for achieving this vision. The paper evaluates the present landscape of AI in Oman's educational system, exploring the current initiatives and how AI can be extended in education and be part of its practices. Based on the nature of the study, the methodology employed involves a comprehensive review of available literature and internet resources related to AI applications in education globally and within Oman. This secondary research approach allows for …

Therapeutic Potential Of Glp-1 Receptor Agonists For Smoking Cessation, Christian S Hendershot, W Kyle Simmons, Manish K Jha, Sherry A Mckee, Luba Yammine

Faculty, Staff and Student Publications

Glucagon-like peptide-1 (GLP-1) therapies are under investigation for a growing number of neuropsychiatric conditions, including substance use disorders. Cigarette smoking accounts for the largest proportion of substance use-related morbidity and mortality, in part reflecting increased risk for cardiometabolic disease among people who smoke. Given modest quit rates with approved smoking cessation therapies, medications with novel mechanisms of action are needed to expand the available monotherapy and combination treatment options. Treatments that prevent post-cessation weight gain could further reduce relapse and cardiometabolic risks following smoking cessation. Preclinical findings show that GLP-1 receptor agonists (GLP-1RA) modulate nicotine reward, reduce nicotine self-administration, and …

Applications Of Machine Learning In Enhancing Evaporation Estimation For Small Reservoirs: A Case Study In Semi-Arid South Texas, Syed Muhammad F Abdullah, Chu-Lin Cheng, Jude A. Benavides, Jungseok Ho, Rafael M. Almeida

School of Earth, Environmental, & Marine Sciences Faculty Publications

Small reservoirs in semi-arid regions experience substantial evaporative losses but are rarely monitored at daily scales. A multi-reservoir machine learning (ML) framework was developed to estimate daily open-water evaporation. Empirical models (Penman, Penman-Monteith, Priestley-Taylor, Bowen Ratio Energy Budget) andabenchmark combination method (Daily Lake Evaporation Model-DLEM) were compared against ML models. Predictors combined gridded meteorology (gridMET) with reservoir attributes (surface area, average depth, maximum depth, and fetch). ML models (Random Forest-RF, Decision Tree-DT, K-Nearest Neighbor-KNN, and Support Vector Regression-SVR) were trained on four reservoirs using data from 2018 to 2025. Results from ML models were further validated using both DLEM and …

Constitutive Ampk Activation Prevents Hepatocellular Carcinoma Development Through Inhibition Of Hnf4Α Activity, Fiyad Alsarmi, Boyuan Sang, Nagireddy Putluri, Jeanine L Van Nostrand

Faculty, Staff and Students Publications

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality and is largely driven by metabolic disorders such as obesity and type 2 diabetes. The AMP-activated protein kinase (AMPK) is a master regulator of metabolism, and its activation has been proposed as a therapeutic strategy for treating metabolic disorders. However, although AMPK activity is down-regulated in HCC, the precise role of AMPK in HCC development has not been clearly delineated. Here, we investigated the ability of constitutive AMPK activation to prevent HCC development using a constitutively active AMPK transgenic mouse model and a pharmacological AMPK activator. We observed that AMPK …

Back Matter

Caroliniana Undergraduate Research Journal

This is the Back Matter for Vol. 1, Iss. 1: "The Blueprint" in the Caroliniana Undergraduate Research Journal. The Back Matter includes the following sections:  The Editorial Board, About the Authors, and the Back Cover of the issue. Here you can find more about the contributors that made this issue possible.

Emergence, Differentiation, And Modeling Of Hematopoietic Stem Cells In Developing Embryos, Lucy Shive

Caroliniana Undergraduate Research Journal

In the field of developmental biology, the understanding of embryogenesis is driven by ever-advancing techniques of studying embryos’ structures and behaviors. Yolk sacs are critical to an embryo’s survival and its function in producing a mature organism from a simple zygote. A hallmark of embryonic yolk sacs is their production of primitive hematopoietic stem cells (HSCs). Recent research has explored the mechanisms by which these HSCs develop and migrate, as well as the mechanisms by which they differentiate into various cell types. This more thorough understanding of HSCs is the basis for the development of embryo models, peri-gastruloids, from stem …

Single-Cell Tcr Mapping Reveals Spatially Coordinated T Cell States In Head And Neck Cancer, Amanda Y Xia, Colby J Hofferek, James S Lewis, Andreas Wieland, David J Hernandez, Vlad C Sandulache, William H Hudson

Faculty, Staff and Students Publications

Current spatial T cell receptor (TCR) profiling approaches lack the resolution needed to link clonal identity, transcriptional state, and spatial positioning of individual T cells in the tumor microenvironment. Here, we introduce a spatial TCR profiling strategy that resolves individual T cell clones together with their transcriptional states at single-cell resolution and applied the method to human head and neck squamous cell carcinoma. Presumed tumor-specific T cells were broadly dispersed throughout the tumor microenvironment, and cells of the same clone occupied distinct transcriptional states in different locations: Immune-rich regions contained more plastic or progenitor cells, whereas tumor-dense regions were enriched …

Loss Of Znrf3/Rnf43 Unleashes Egrfr In Cancer, Megan N Michalski, Weiyu Jiang, Jianghua Tu, Zhongcheng Shi, Yongchao Dou, Yi Wang, Xin-Hua Feng, Galen Hostetter, Xiangwei Wu, Shixia Huang, Noah F Shroyer, Bing Zhang, Bart O Williams, Qingyun Liu, Xia Lin, Yi Li

Faculty, Staff and Students Publications

ZNRF3 and RNF43 are closely related transmembrane E3 ubiquitin ligases with significant roles in development and cancer. Conventionally, their biological functions have been associated with regulating WNT signaling receptor ubiquitination and degradation. However, our proteogenomic studies have revealed EGFR as the protein most negatively correlated with ZNRF3/RNF43 mRNA levels in multiple human cancers. Through biochemical investigations, we demonstrate that ZNRF3/RNF43 interact with EGFR via their extracellular domains, leading to EGFR ubiquitination and subsequent degradation facilitated by the E3 ligase RING domain. Overexpression of ZNRF3 reduces EGFR levels and suppresses cancer cell growth in vitro and in vivo, whereas knockout of …

Exploring How Long-Term Residents Influence Environmental Policy Decisions In The Takushara Settlement In Abuja, Nigeria, Agbanusi Uchechukwu Jonathan

Walden Dissertations and Doctoral Studies

Rapid urbanization of Nigeria’s Federal Capital Territory (FCT) has increasingly marginalized indigenous communities, creating a significant disconnect between top-down environmental governance and how it affects residents. Previous research has found that this land swap displaces indigenous stewards and erodes their traditional ecological knowledge, endangering local livelihoods, food security, and sustainable management of natural resources. The purpose of this narrative qualitative study was to explore how long-term residents perceive and experience their influence in environmental policy decisions through the lens of the social-ecological systems framework and the theory of resilience. This study examined the systematic exclusion of long-term residents of the …

Risk Factors Affecting Functional Outcomes Of Traumatic Brain Injury Patients During Long-Term Acute Care Hospital Rehabilitation, Arturo Olazabal

Walden Dissertations and Doctoral Studies

Traumatic brain injury (TBI) is a major public health concern associated with long-term disability and high healthcare utilization. Evidence guiding post-acute rehabilitation for medically complex TBI populations remains limited, particularly in long-term acute care hospital (LTACH) settings serving medically unstable patients. This study examined clinical and system-level factors associated with functional rehabilitation outcomes among adults with moderate-to-severe TBI in LTACHs. Guided by the Socioecological Model, recovery was conceptualized as interactions across individual, clinical, and organizational levels. This dissertation included three manuscripts using cross-sectional logistic regression and CMS Section GG measures. In Manuscript 1, longer time from injury to LTACH admission …

Foster Parents' Experiences Faced With Older Foster Children During Covid-19, Tisha S. Nicholson

Walden Dissertations and Doctoral Studies

The COVID-19 virus was a new virus that caused a worldwide pandemic. There was not much information about what the virus was, what caused it, or how to stop its spread. Vulnerable populations such as those in foster care were especially affected because the foster children had no place to go. The purpose of this qualitative study was to explore the lived experiences of foster parents who had older foster children in their care during the COVID-19 pandemic. There was a lack of research specifically on foster parents and their personal lived experiences with the foster care system and foster …

Lingkungan Sebagai Subyek Hukum Dan Kewenangan Publik Lsm Lingkungan, Dr. Daud Silalahi, S.H.

Jurnal Hukum & Pembangunan

Abstract

Genetic Secrets Unveiled: Unraveling Privacy Concerns In Direct-To- Consumer Genetic Testing Between The United States And The European Union, Sofia Marie Cabrera

Journal of International Law and Comparative Studies

No abstract provided.

Fool's Gold: The Stibnite Gold Project, Critical Minerals, And The Public Health Perils Of Antiquated Hardrock Mining Laws, Faith Quigley

Idaho Law Review

The proposed reopening of the Stibnite Gold Mine in Idaho has been heralded as a model for the future of modern hardrock mining. This project has received national interest in light of the growing domestic demand for critical minerals essential to climate-friendly energy technologies and national security. But beneath its green branding lies a deeper legal and public health crisis. Operating under the General Mining Law of 1872—a relic of frontier-era resource exploitation—the Stibnite Gold Project exemplifies how an outdated legal framework continues to enable environmental and human harm. While policymakers tout the domestic necessity of critical minerals, the Stibnite …

Facing The Accused: The Confrontation Clause And Protecting Child Victims Of Sexual Abuse, Raquel Pearson

Idaho Law Review

The Sixth Amendment’s Confrontation Clause provides individuals the right to confront witnesses testifying against them. For decades, Idaho case law has grappled with the delicate balance between protecting victims of sexual assault and upholding defendants’ rights to cross examine their accusers. This delicate balance is further exacerbated when sexual assault cases involve minors, particularly in deciding whether victim statements implicate the Confrontation Clause. The Idaho Supreme Court considers the totality of the circumstances when evaluating whether a defendant’s right to confront a witness has been violated, but the standard for when the Clause is triggered remains unclear.

This Note seeks …

Thyroid Hormone Receptor Alpha In Mitochondrial Transcription, David J. Mahrt

Linfield University Student Symposium: A Celebration of Scholarship and Creative Achievement

Mitochondrial DNA (mtDNA) encodes core proteins in the electron transport and oxidative phosphorylation pathway. The remaining subunits of these protein complexes are encoded in the nuclear genome, translated in the cytosol and imported into mitochondria. Transcription of mtDNA transcription is achieved with three core factors: mitochondrial RNA polymerase (POLMRT), mitochondrial transcription factor A (TFAM), and mitochondrial transcription factor B2 (TFB2M). Regulation of this process requires additional proteins, and likely transcriptional coordination with the nuclear genome. We propose that the thyroid hormone receptor alpha (THRA) acts to coordinate transcription between the two genomes. The thyroid hormone, triiodothyronine (T3), increases mitochondrial biogenesis …

Study The Effect Of Climate Change On Barley Crop (Hordeum Vulgare L.) And Improving Its Productivity Through Municipal Treated Wastewater Utilization, Wasef A. Alzayadneh

Thesis/ Dissertation Defenses

Climate change presents a complex risk to crop productivity, with elevated temperatures, rising CO2 and UV-B enhancement profoundly impacting growth. Although the effects of individual stressors are well-documented, limited information is available regarding the combined effects of variables such as elevated CO₂ (eCO2), UV-B radiation, and elevated temperature (eT). This knowledge gap is especially critical for major cereal crops such as barley (Hordeum vulgare L.), which ranks fourth in global production and serves as a valuable source of forage for livestock. However, traditional forage production is unsustainable in arid regions, where water shortage and extreme weather conditions are present, as …

Studying The Role Of Combitional Flavonoids Against Toxicity Of Chemothrapeutic Drugs In Human Fibroblast Cells, Hussain Al Zouabi

Thesis/ Dissertation Defenses

Chemotherapy remains the primary treatment strategy for cancers; however, its clinical efficacy is often limited by severe toxic effects resulting in normal cells. The study investigated the protective potential of the flavonoids epigallocatechin-3-O-gallate (EGCG) and quercetin, used in combination, against chemotherapy-induced toxicity in human fibroblast F-180 cells. Cells were exposed to three commonly used chemotherapeutic agents, doxorubicin, cisplatin, and etoposide, in the presence or absence of EGCG and quercetin at concentrations of 25 and 50 μM. cells viability was assessed using the MTT assay, while oxidative stress and antioxidant capacity were evaluated by intracellular reactive oxygen species (ROS) and total …

Forest Characteristics And Avian Community Differences Among Cerulean Warblers (Setophaga Cerulea) Use Types, Dustin Kohler

ATU Scholars Symposium

Avian species are often used to measure the health of an ecosystem, in part because the specific forest structure can significantly impact the avian community. A heterogeneous landscape can support a more diverse avian community and benefit specialist species like the Cerulean Warbler (Setophaga cerulea), a rapidly declining, neotropical migrant that can be found in large deciduous forests. The Ozark Mountains of northwestern Arkansas represent a small core area for the species, but at all sites in the upland Ozarks where Cerulean Warbler research has been conducted, there are fewer individuals than there were twenty years ago; some …

Exploring Patterns Of Microhabitat Use Among Darters In The Lower Little River Watershed, Arkansas, Nate J. Martin, Savannah L. Wise

ATU Scholars Symposium

In this study, we seek to explore patterns of microhabitat use among darters, including variables of stream depth, water velocity, substrate composition, aquatic vegetation, and woody debris cover. The most informative microhabitat variables will be assessed using nonmetric multi-dimensional scaling (NMDS). Species with more than five individuals collected were included in analysis, totaling eight species across 24 sites in the Lower Little River Watershed of southwest Arkansas. We caught 28 Plains Darters (Etheostoma pulchellum), 27 Dusky Darters (Percina sciera), 21 Orangebelly Darters (Etheostoma radiosum), 16 Channel Darters (Percina copelandi), 13 Harlequin Darters (Etheostoma histrio), 11 Common Logperch (Percina caprodes), 7 …

Car-T Cell Therapy – A Revolutionizing Cancer Treatment Through Precision Immunotherapy, Mackenzie R. Epperson

ATU Scholars Symposium

Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a great advancement in the field of oncology, offering a targeted and adaptable cancer treatment. Traditional therapies, including surgery, chemotherapy, and radiation often have limitations, such as relapse and resistance, highlighting the need for more precise therapeutic options. CAR-T therapy addresses many of these challenges through engineering a patient’s own T-cells to recognize and destroy cancerous cells with specificity and long-lasting immune activity. Since being approved by the FDA in 2017, CAR-T therapy has shown success in treating hematologic malignancies, demonstrating high remission rates in patients with previously limited options. Despite …

Comprehensive Temporal, Spatial, And Environmental Analysis Of Arkansas Tournament Information Program (Atip) Data With A Lake Dardanelle Case Study., Jeffrey G. Phillips

ATU Scholars Symposium

The Arkansas Game and Fish Commission (AGFC) established the Arkansas Tournament Information Program (ATIP) in 1990 to provide a long-term, standardized dataset to describe Black Bass (Micropterus spp.) tournament outcomes, angler performance, and fish size structures across Arkansas, yet most of its analytical potential has not been fully explored beyond yearly summary reports. This project will use ATIP data from 1990 to 2027 and a biological case study from Lake Dardanelle to evaluate long-term trends, compare lake-specific performance, identify environmental drivers of tournament success, access how well tournament data represents true Black Bass populations, and create an “average” year benchmark …

Deep Spiking Neural Network Autoencoders For Efficient Temporal Data Compression, Shruti Bhandari

ATU Scholars Symposium

High dimensional temporal data processing, such as that required for neuroprosthetics and remote physiological monitoring presents significant challenges for real time deployment because transmitting and storing raw signals is computationally demanding and energy intensive. Effective data compression is essential to act as a "biological zip file," reducing transmission bandwidth while preserving the critical temporal features required for accurate signal reconstruction and analysis. This study proposes a deep Spiking Neural Network (SNN) Autoencoder designed for high-fidelity data compression by utilizing the event-driven firing behavior of Leaky Integrate-and-Fire (LIF) neurons, which ensures extreme computational efficiency compared to traditional models. The model is …

Investigating The Effect Of Kcl Stress In Raphanus Sativus, Mason P. Oelke

ATU Scholars Symposium

Presented by Stephanie Nelms at the Arkansas INBRE Conference on November 7-8, 2025.

Presented by Mason Oelke at Arkansas Tech Scholar's Symposium on April 9th, 2026.

Potassium is an essential macronutrient for plant growth and development, yet excessive potassium fertilization can induce salt stress with detrimental consequences for crop productivity and nutritional quality. Despite its agricultural relevance, potassium chloride induced stress remains significantly understudied compared to classical sodium-based salinity. This thesis investigates the physiological, biochemical, and molecular responses of Raphanus sativus to KCl stress using an integrated approach that combines germination assays, mineral profiling, and gene expression analysis.

Radish seeds …

Re-Purposing Pre-Existing Tilapia Aquaculture Open-Design System For Zebrafish Biomedical Research Purposes, Luke Cantu, David Sierra, Skyleigh Curtis, Maya Avila

ATU Scholars Symposium

Title: Re-purposing pre-existing tilapia open-design aquaculture systems for zebrafish biomedical research purposes.

Background: Zebrafish (Danio rerio) models are gaining popularity in biomedical research; however, the high infrastructure cost, at approximately $20,000 per unit, is a significant hurdle for primary undergraduate institutions (PUIs) establishing zebrafish facilities. This study assesses if repurposing existing tilapia open-design aquaculture systems could be a cost-effective method for zebrafish facility establishment.

Methods: Between November-2025 to February-2026, the study used a pre-existing tilapia aquaculture open-design system with personnel modified outlet filters. The water quality of this system was monitored and recorded. The study compared the stabilization phase or …

Incorporating Local Expertise Into Environmental Research And Management, Jessica Black, Amy E. Scaroni, Stefanie L. Whitmire

Forestry and Natural Resources

This article is for researchers, government staff, land planners, and natural resource managers. In this paper, we will outline why incorporating local expertise works to scale down national or regional research to make it more useful for local communities. We will also provide examples of how a community’s knowledge about their local ecosystem, referred to as local ecological knowledge (LEK), can fill data gaps and contribute to improved land and wildlife management.

Conservation Gap Analysis Of The Endemic Flora Of Nevada (U.S.A.)​, Jodi D. Dunn

ATU Scholars Symposium

Introduction. Nevada is the driest state in the U.S. and spans multiple desert and montane biomes, containing over 3,000 species of plants across its varied environmental gradients. Within this flora, 268 species occur as regional endemics, with narrowly restricted distributions contained either fully, mostly, or partly within Nevada’s political boundaries. Preliminary investigation led us to hypothesize that most of the distributions of these rarities occur outside of currently protected areas. Methods. A list of endemic species was derived from the mentor’s work treating all Nevadan plants. Occurrence records with geographic coordinates were extracted into Excel spreadsheets. For occurrences without specified …

Fish Community Assessment Of Goose Pond Natural Area, Macy Sparks

ATU Scholars Symposium

Natural areas play an integral role in the preservation and conservation of unique ecosystems (i.e., natural wetlands). However, many natural areas have never had a biological inventory of species utilizing these areas. Goose Pond Natural Area (Conway County and Pope County, Arkansas) is one of those natural areas lacking species occurrence data. We addressed this data gap by sampling fish species across multiple habitat types (shallow woody wetland, open grassy wetland, and stream). We employed multiple gear types (mesh umbrella minnow traps, seines, gill nets, mini-fyke nets, and backpack electrofishing) in hopes of increasing species detection. Sites within the natural …