Digital Commons Network^™

The Case For Lgbtq+ Adoption Rights In The Post-Roe Era, Tate Craft

Kentucky Law Journal

No abstract provided.

Modeling And Optimization Of Ppsu/Cu-Bdc Mmms And Ppsu/Cooh-Mwcnt@Cu-Bdc Mmms For Enhanced Water Treatment Performance, Ghaidaa M. Jaid, Adnan A. Abdulrazak, Sunarti Abdul Rahman, Muayad Al-Shaeli, Vahid Vatanpour, Qusay F. Alsalhy

Engineering and Technology Journal

Water quality is increasingly of concern today due to industrial wastewater that contains heavy metals, particularly lead (Pb²⁺). What follows is a study aiming at adjusting operational variables affecting the performance of two types of mixed-matrix membranes (MMMs) used for lead ion removal from simulated wastewater. The first employs polymer polyphenylsulfone (PPSU) by embedding copper-organic frameworks (Cu-BDC), and the second MMMs incorporate a novel COOH-MWCNT@Cu-BDC nanocomposite in the same polymer. MOF nanoparticles were added to the matrix to improve membrane performance, hydrophilicity, contact angle, porosity, and fouling resistance. Three operating parameters were modeled and optimized for their influence …

Stratifying Renal Risk In End-Stage Renal Disease: Evidence From A Population-Based Dialysis Registry In Northern Saudi Arabia, Reem Eltayeb, Naif K Binsaleh, Ghaida A Alsaif, Mona Hm Ahmed, Ahmed M Taha, Abdelhameed Abdelzaher, Zinab Alatawi

Saudi Medical Journal

Objectives: We examined the relationship of age, gender, smoking, nationality, and place of residence with renal dysfunction severity in end-stage renal disease (ESRD) patients. Methods: We performed a cross-sectional study of ESRD registry data collected from King Khalid Hospital in Hail, Saudi Arabia. Adults (≥ 15 years) treated from March 2023 - February 2024 were enrolled. Serum creatinine and urinary albumin concentrations were measured (based on primary [≥ 625 μmol/L and ≥ 18 mg/L, respectively] and sensitivity thresholds). Bivariate analyses, interaction testing, sensitivity models, and multivariable logistic regression were employed. Results: Of 212 patients (50.9% male), based on primary thresholds, …

Microbiological Profile And Antibiotic Resistance In Relation To Risk Of Recurrence And Fistula Following Perianal Abscess Drainage: A Retrospective Study, Saleh A. Busbait

Saudi Medical Journal

Objective: The practice of obtaining routine intraoperative cultures and administering postoperative antibiotics for perianal abscess treatment continues to be debated, so far, there is no established evidence linking these practices to improved patient outcomes. This study investigated the microbial distribution together with antibiotic resistance and their relationship to abscess recurrence or fistula development. Methods: The study analyzed 242 patients who received their first perianal abscess treatment through incision and drainage procedures at a Saudi Arabian tertiary center from 2019 to 2023. Swab cultures were obtained intraoperatively. A descriptive statistics, Chi-square tests and antibiotic resistance were analyzed. Results: The most frequently …

An Investigation Of The Correlation Between Total Intracranial Volume And Body Mass Index, Walaa M. Alsharif, Fahad H. Alhazmi, Ali D. Almutairi, Rahaf M. Alharbi, Lana M. Alsaedi, Razan A. Alharbi, Amirah F. Alsaedi, Abdulaziz A. Qurashi, Adnan A. Alahmadi, Khalid M. Alshamrani, Faisal A. Alrehily, Shrooq T. Aldahery, Osamah M. Abdulaal, Reem M. Elkady

Saudi Medical Journal

\looseness-1 Objective: Total intracranial volume (TICV) is an important covariate in brain volumetric analysis that can vary significantly between participants. This study aimed to investigate the association between body mass index (BMI) and TICV. Methods: 152 healthy volunteers were recruited. The BMI was calculated, and T1-weighted images were acquired to estimate brain volumetric values. The data were analyzed using volBrain software. Results: Male participants have significantly higher GM, WM, CSF, TICV, cerebellum GM, cortical GM, subcortical GM and cerebrum GM volumes compared to female. There were significant differences in GM, TICV, cerebellum GM, cortical GM, subcortical GM and cerebrum GM …

A Comprehensive Analysis Of Overweight, Obesity, And Failure To Thrive In Pediatric Inpatients: Prevalence, Diagnostic Practices, And Management Approaches At A Tertiary Hospital In Riyadh, Saudi Arabia, Ibrahim A Al Alwan, Elaf A Alshammari, Ahmed A Alabdulkarim, Abdulaziz A Ajeebi, Afnan A Alhazimi, Nawaf A Alhamied, Deema Y Alasmari

Saudi Medical Journal

Objective: This study aimed to assess the prevalence, diagnostic accuracy, and inpatient management of pediatric weight abnormalities at a tertiary children's hospital in Riyadh, Saudi Arabia, using a retrospective cohort design. Methods: The study analyzed medical records of pediatric inpatients aged 2–14 years admitted to King Abdullah Specialized Children's Hospital (KASCH) in 2023. Data collected included anthropometrics, dietary history, physical activity, diagnostic workup, and treatment plans. Overweight and obesity were classified using BMI percentiles, while FTT was identified via weight-for-age and growth percentile criteria. Descriptive statistics were used to analyze diagnostic accuracy and factors influencing missed diagnoses. Results: Of 7,771 …

Mapping Health Research Involving Human Subjects In Saudi Arabia: A Text Mining And Topic Modeling Analysis, Khalid A. Alhussain

Saudi Medical Journal

Objectives: To identify dominant and underrepresented research topics and to classify published studies by design and data sources in health research involving human subjects from Saudi Arabia. Methods: This retrospective study analyzed PubMed-indexed health articles related to Saudi Arabia from 1959 to March 2025. Text mining was used to identify studies conducted in the country involving human subjects. Eligible articles were classified by study design and data sources. Topic modeling using non-negative matrix factorization was applied to identify topics based on the primary research focus. Results: A total of 36,452 records of studies conducted in Saudi Arabia were initially identified. …

Translational Barriers To Aav And Crispr Gene Therapy In Diabetes, Abdulrahman G. Alharbi

Saudi Medical Journal

Gene therapy targets diabetes pathophysiology rather than symptoms, yet clinical translation is slower than preclinical success. This review synthesizes 143 registered trials (ClinicalTrials.gov, 2010-2025) identifying systematic implementation barriers. Despite >15 years of development, 83% of trials remain in Phase I-II. Only zimislecel achieved Phase III outcomes (83% insulin independence at 12 months, n=12, requiring immunosuppression). VM202 for diabetic neuropathy failed Phase III despite positive extension results. Three systematic barriers emerged: (1) human transduction efficiency is 6-8.7-fold lower than preclinical models; (2) pre-existing immunity excludes 58-78% of candidates; (3) manufacturing capacity serves <2.5% of target population (40-400 years to treat at maximum capacity). These constraints explain why ex vivo cell therapies advanced to efficacy trials while in vivo gene delivery remains in Phase I despite longer development timelines. Research priorities should emphasize non-viral delivery systems offering scalable manufacturing and universal hypoimmune donor cells to address access barriers.

Health Effects Of Cadmium And Manganese Exposure On Luteinizing Hormone Levels: A Pilot Study Of Female Infertility, Shatha F. Alhous, Anees A. Al-Hamzawi, Murtadha Sh. Aswood

Al-Bahir

Female infertility occurs for many reasons, some unknown. Exposure to heavy metals is a risk factor that negatively impacts on female reproductive system. Therefore, this study aimed to evaluate the effect of cadmium Cd and manganese Mn on luteinizing hormone LH levels for females’ infertility. This study included a healthy group (n = 20), primary infertile females (n = 40), and secondary infertile females (n = 20) collected from Al-Zahraa hospital in Najaf center, Iraq. The Atomic Absorption Spectroscopy (AAS) was used to measure the cadmium and manganese concentrations and LH levels were measured by a Maglumi 800 from Snibe …

Enhanced Cuckoo Search-Based Optimization For Single Distributed Generation Placement And Sizing In Radial Distribution Systems, Samson Oladayo Ayanlade, Abdulrasaq Jimoh, Richard Oladayo Olarewaju, Ignatius Kema Okakwu, Israel O. Adejumobi, Joseph B. Samson, Oluwadare A. Adebisi, Oluwadare O. Akinrogunde

Al-Bahir

This paper presents an Enhanced Cuckoo Search Algorithm (ECSA) to optimally place and size Distributed Generation (DG) in radial distribution systems to minimize real power loss within operating constraints. The proposed ECSA has exponentially decaying adaptive Lévy flights, constraint-aware solution repair with dynamic penalty coefficients, and diversity-directed stochastic replacement to enhance search robustness and convergence speed. It was tested with 30 independent runs on the IEEE 33-bus, IEEE 69-bus, and a practical Nigerian 32-bus distribution network. The simulations show that the ECSA lowers the active power loss of the IEEE 33-bus system from 201.58 kW to 102.75 kW (49.03%), and …

May Federal Courts Create New Presumptions?, Emile J. Katz

Penn State Law Review (2003 - Present)

No abstract provided.

Clinical Prediction Of Posttreatment Migraine Recurrence Using Biofeedback Data: A Machine Learning Framework For Enhanced Patient Stratification And Treatment Monitoring, Shibbir Ahmed Arif, Ferdib-Al-Islam, Mehidy Hasan Sium

School of Computing Faculty Scholarship and Creative Works

Migraine is a complex neurological disorder with significant implications for individual well-being and public health. Predicting migraine occurrences after treatment is crucial for evaluating therapeutic efficacy and enabling personalized care, yet remains largely underexplored. This study proposes a robust machine learning framework to predict posttreatment migraine headache occurrences using real-world headache log data collected from 133 patients undergoing biofeedback therapy. The methodology includes rigorous data preprocessing, outlier removal via the interquartile range (IQR) method, and class imbalance correction through the synthetic minority oversampling technique (SMOTE). A total of 10 classical and a hybrid ensemble machine learning models were developed and …

Studying The Level Of Amyloid-A And Fibrinogen-Like Protein 1 And Other Biomarkers In The Sera Of Rheumatoid Arthritis Of Iraqi Patients, Aya Waleed Aziz, Bushra Faris Hasan

Baghdad Science Journal

Rheumatoid arthritis (RA) isa common chronic autoimmune disease characterized by synovitis causing pain and inflammation and can result in joint destruction, its risk factors involve a family history of disease, obesity, smoking as well as viral infections. In this study, serum amyloid A and fibrinogen-like protein 1 were evaluated in 80 patients and 40 healthy controls (both men and women). Measurement of SAA, FGL1, RF, CRP, and MPO were performed using ELISA kits, the colorimetric method has been employed for estimating lipid profile, and Westergren method has used to measure ESR. The results indicated that levels of SAA, FGL1, MPO, …

Quantitative Analysis Of Thiamine, Riboflavin, And Niacin Vitamins By High-Performance Liquid Chromatography In Pharmaceutical Sample Tablets And Drops, Sarra A. Abrahem, Suhad A. Ibrahim, Alaa Sh. Abdulbari, Noor M. Ali, Maryam Y. Hashim

Baghdad Science Journal

Levering cutting-edge high-performance liquid chromatography techniques with a C-18 column, we meticulously crafted a gradient of MeOH and glacial CH₃COOH (96–5%), pulsating through at a mesmerizing 1.2 ml/min. With ultraviolet detection at a precise wavelength of 245 nm, we unraveled the mysteries of these vital nutrients. Thiamine reveals itself at a retention time of 3.5 min, followed by Riboflavin at 8.1 min and Niacin at 10.8 min. The findings of this study were not just a spectacle of scientific powers but were also rigorously benchmarked against commercial drugs, ensuring accuracy and reliability in our analysis.

Determination Of Trace Pyridoxine Hydrochloride (Vitamin B6) In Dosage Forms And Redbull Samples Using Dispersive Liquid-Liquid Microextraction Technique Coupled With Spectrophotometry, Sally Ghanem Ahmed, Wijdan Shakir Khayoon

Baghdad Science Journal

This paper introduced a sensitive determination method measurement spectrophotometric coupled with dispersive liquid-liquid micro extraction based on charge transfer complex formation between pyridoxine hydrochloride and chloranil using alkaline buffer (pH = 10.5). After that, the extraction of charge transfer complex was conducted by injection a mixture of chloroform and acetone solvents followed by spectrophotometric measurement of tiny organic droplets at λ = 535 nm. The important parameters affecting the formation of the complex and efficiency of DLLME such as concentration of chloranil, volume and pH of buffer solution, reaction time and the optimum conditions of DLLME has been studied and …

Stimulation Of The Medial Septum Diagonal Band Of Broca Rescues Learning And Memory Deficits In Fmr1 Ko Mice, Mohamed Ouardouz, Amanda E Hernan, J. Matthew Mahoney, Rodney C Scott

SKMC Student Presentations and Publications

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disability and a leading monogenic cause of autism, arises from the loss of Fragile X Messenger Ribonucleoprotein (Fmr protein), leading to synaptic and cognitive dysfunction. Here, we demonstrate that the frequency-specific electrical stimulation of the medial septum/diagonal band of Broca (MSDB) can restore cognitive and synaptic impairments in Fmr1 knockout mice, a validated model of FXS. Thirty minutes of 35 Hz MSDB stimulation significantly improved subsequent recognition memory, sociability, spatial learning, and fear memory, with recognition memory enhancements persisting for up to 7 days after daily 30 min …

The Zircon, March 20, 2026 [Spoof Issue], Dordt University

Dordt Diamond

No abstract provided.

Redefining Online Education: Integrating A Quality Assurance Rubric Process In A Community College Setting, Judy K. Howell

Morehead State Theses and Dissertations

A capstone submitted in partial fulfillment of the requirements for the degree of Doctor of Education in the Ernst and Sara Lane Volgenau College of Education At Morehead State University by Judy K. Howell on Kentucky March 20, 2026.

Receptor-Mediated Drug Delivery: Redefining Targeted Drug Conjugates In Oncology, Keon Niles Jafari, Charlene Chai, Shelby Kim, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Targeted drug delivery (TDD), specifically through targeting ligand–drug conjugates, has reshaped oncology by enabling selective delivery of cytotoxic payloads to cancer cells while minimizing uptake by normal tissues. A key approach relies on exploiting overexpressed cell surface receptors (CSRs) to enable selective uptake of drug conjugates via receptor-mediated endocytosis. This review delineates four clinically validated CSRs (HER2, Trop-2, Nectin-4, and SSTR2) with several FDA-approved drug conjugates. Furthermore, emerging CSRs (EGFR, DLL3, and keratin 1) that may support next-generation TDD platforms for cancer treatment are also highlighted. We discuss how CSR type, density on cancer cells, and its mechanism of endocytosis, …

Identification Of Thruster Faults In Underwater Vehicles By Using Custom Encodings In Spiking Neural Networks, Donovan Gegg

LSU Master's Theses

Autonomous Underwater Vehicles (AUVs) are untethered robotic platforms used for tasks such as seafloor mapping, infrastructure inspection, and environmental monitoring. Recent technological advances have produced smaller, more affordable platforms, broadening access to research teams and small companies alike. This miniaturization comes at the cost of them handling drawbacks associated with a more compact machine such as reduced battery capacity as well as limited processing and sensing capabilities. These constraints make small-sized marine vehicle’s reliability critical as they can cause malfunctions, making the loss of a vehicle more likely. Actuator faults are particularly consequential as unintended and unstable control in an …

Antibacterial Activity Of Sapium Ellipticum, Securidaca Longepedunculata, And Allophylus Africanus Against Drug-Resistant Pseudomonas Aeruginosa Isolates, Eleonora A. Mbare, Rose J. Masalu, Cyprian B. Mpinda

Tanzania Journal of Science

Pseudomonas aeruginosa poses a major clinical challenge due to its high levels of antibiotic resistance. This study evaluated the antibacterial activity of three medicinal plant extracts Allophylus africanus (leaves), Securidaca longepedunculata (root bark), and Sapium ellipticum (stem bark), against 30 drug-resistant P. aeruginosa isolates. Antibacterial screening was conducted using the agar well diffusion method, followed by determination of minimum inhibitory concentrations (MICs) via a 96-well microtiter plate assay. All three plant extracts demonstrated inhibitory activity against three resistant P. aeruginosa strains (gentamicin-resistant strains F4 and GR4RAU-AI, and ceftazidime-resistant strain 19-10), with inhibition zones of varying diameters. MIC values showed strain-specific …

Honey Bees (Apis Mellifera) Pollination Enhances Watermelon (Citrullus Lanatus) Yield In Kibaha Tanzania, Beatrice Tonola, Charles Olambo Joseph, Mkabwa L.K. Manoko, Shibonage K. Mashilingi

Tanzania Journal of Science

Honey bees are essential pollinators of the world’s food crops. However, information on the influence of honey bee pollination on watermelon yield is limited in Tanzania. This study assessed efficiency of honey bee pollination on watermelon yield. The study tested three improved watermelon varieties (Zebra F1, Candy F1 and Sukari F1) and three pollination environments: (Caged with Apis mellifera (CAM), Caged without insects (CW) and Open pollination (OP) in two seasons. The experiment was arranged in a split-plot design in randomized complete block design (RCBD) with three replications. Results showed no significant interaction between pollination environment and varieties. Significant difference …

Effects Of Substrate–Supplement Interactions On Yield Performance Of Oyster Mushroom (Pleurotus Ostreatus), Charles O. Joseph, Faraja Makwinja

Tanzania Journal of Science

Different substrates and supplements are used in mushroom production, however their interaction effects and growth variables affected is little known. This study was conducted to compare the effects of substrate-supplement interactions on growth and yield of oyster mushrooms Pleurotus ostreatus. Two substrates (banana leaves and sawdust) and two supplements (chicken manure and sugar) were investigated. The substrates were reduced to 2 cm pieces and steam sterilized at 80–100°C for 3 hours. In each bag containing specific substrate, the supplements were added as 2% of the total substrate. The spawn was inoculated from each bag; misting was applied to maintain constant …

Heavy Metal Contamination In Agricultural Soils And Potential Human Health Risks, Debora Michael Mwenda, Leonard Masesa Jumanne, Daudi Salvius Mgaya, Amos Vincent Ntarisa

Tanzania Journal of Science

Heavy metal contamination in agricultural soils is a growing concern due to potential human health risks via ingestion, dermal contact, and inhalation. However, data on fertiliser-related contamination in rural Tanzanian settings remain limited. This study assessed contamination levels and associated health risks in Kibwabwa village, Iringa, Tanzania. A total of 48 soil samples were collected from eight farms at a depth of 0–15 cm. Concentrations of Cu, Zn, Ni, Cd, Cr, and Pb were determined using Atomic Absorption Spectroscopy (AAS). Health risks were evaluated using chronic daily intake (CDI), hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR) models …

Fenced And Feral: Farming And Spread Of Flowerhorn (Amphilophus Spp.) In Lake Sampaloc, Philippines, Janice A. Ragaza, Hannah Nicole Gasmen

Environmental Sustainability

This study examines the spread and ecological impact of invasive Flowerhorn cichlids (Amphilophus spp.) in Lake Sampaloc, Philippines, driven by both accidental release and intentional aquaculture practices. Field observations and literature reveal that these highly adaptable and aggressive fish outcompete native species, contributing to biodiversity decline amid increasing pollution, eutrophication, and microplastic contamination. Their phenotypic plasticity allows them to thrive in degraded environments, further exacerbating ecological imbalance. While local communities have begun utilizing Flowerhorns for ornamental trade and potential aquafeed production, such practices risk reinforcing their proliferation. The study highlights the need for integrated management strategies combining biosecurity, pollution control, …

Conquering Today's Health Paradox With The Power Of Heal - An Expert Consensus Report Plus Research Priorities And Policymaker Roadmap, Katharina C Wirnitzer, Mohamad Motevalli, Derrick R Tanous, Clemens Drenowatz, Maximilian Moser, Holger Cramer, Thomas Rosemann, Karl-Heinz Wagner, Andreas Michalsen, Beat Knechtle, Zlatko Fras, Adilson Marques, Nataša Fidler Mis, Fatima C Stanford, Christian Schubert, Nandu Goswami, Claus Leitzmann, Per Morten Fredriksen, Gerhard Ruedl, Rodrigo A Lima, Christian Kessler, Michael Jeitler, Naim A Khan, Hassan Joulaei, Maryam Fatemi, Karl W Kratky, Kara K Palmer, Bernd Haditsch, Boštjan Jakše, Walter Kofler

School of Health Professions

BACKGROUND: Despite growing scientific evidence and health guidelines, the global health paradox persists, with rising lifestyle-related diseases and escalating healthcare costs exposing the inadequacy of current efforts.

OBJECTIVE: Three multidisciplinary congresses were held to generate evidence-based conclusions aimed at addressing the global health paradox.

METHODS: A total of 58 experts from 62 entities participated in the international research and knowledge-exchange panels. Experts reviewed the latest findings to develop practical strategies and identify key research and policy priorities, focusing on the Healthy Eating & Active Living (HEAL) approach.

RESULTS CONCLUSION AND RELEVANCE: The expert consortium endorsed a 33 evidence-based consensual-statement policy …

Comparing The Levels Of Some Biochemical Markers In Rheumatoid Arthritis Patients With And Without Depression, Shnst Ibrahim Mohamed Ali, Israa Ghassan Zainal

Baghdad Science Journal

One of the most common comorbidities of rheumatoid arthritis is depression, which is an independent mood disorder. This study aims to examine the blood levels of some biochemical markers in rheumatoid arthritis patients with and without depression compared to healthy group. This study included three groups: rheumatoid arthritis patients with depression, rheumatoid arthritis patients without depression, and a healthy group. The results showed that patients groups had significantly (P ≤ 0.05) higher activity of acetylcholine esterase and ceruloplasmine, carbonyl, ischemic modified albumin (IMA), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α ), Haptoglobin, and Cupper, and significantly (P ≤ 0.05) …

First Record Of Keratitis Caused By Valkampfia In Iraq, Turkan K. Karyagdi

Baghdad Science Journal

Acanthamoeba is the most well-known causes amoebic keratitis. However, other free-living amoebas (FLA), such as Valkampfia, can also causes of keratitis. Twenty-two samples were collected from cases suspected of amoebic keratitis in Kirkuk Hospital to investigate the presence of Acanthamoeba . Cultivation process was carried out directly on non-nutrient agar (NNA) medium supported with killed Escherichia coli bacteria. Inverted and light microscope were used at 40X magnification to diagnose cultures growth .Only two samples showed positive growth on NNA medium. However, no any presence of Acanthamoeba was observed as were expected using polymerase chain reaction (PCR) which ampilified by …

First Epidemiological Assessment: Syphilis Seroprevalence Among Asymptomatic Blood Donors In Merowe, Northern Sudan, 2022, Doaa Albagir Ahmed, Sabra Alfadil Ibrahim, Hiba Elsadig Salah, Hamad A. Albagir

Saudi Toxicology Journal

Syphilis remains a significant transfusion-transmissible infection, yet regional epidemiological data from Northern Sudan are lacking. This study aimed to establish preliminary baseline syphilis seroprevalence among asymptomatic blood donors in Merowe, Northern Sudan. A cross-sectional study was conducted in January 2022 at the Merowe blood donation center. Eighty-nine consecutive asymptomatic male blood donors were screened for anti-Treponema pallidum antibodies using a commercial Enzyme-Linked Immunosorbent Assay (ELISA) kit (Fortress Diagnostics, UK). Demographic data were collected via structured questionnaire. The overall seroprevalence was 2.25% (2/89; 95% CI: 0.6–7.9%). The donor population median age was 32 years (range: 18–64). Both reactive donors were referred …

Bioclimatic Reorganization Of Carbon–Water–Energy Coupling Revealed By Eddy Covariance And Interpretable Machine Learning, Koong Yi, Margaret S. Torn, Gabriel B. Senay, Lixin Wang, Kosana Suvočarev, Joshua B. Fisher, Arman Ahmadi, Housen Chu, Gil Bohrer, Georgianne W. Moore, Stephen P. Good, Steven A. Kannenberg, Justine E. C. Missik, Kanishka Mallick, Kul Khand, Youngryel Ryu, Kuno Kasak, A. Christopher Oishi, David E. Reed, Xiangzhong Luo, Carl J. Bernacchi, Dennis Baldocchi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Ecosystem exchanges of carbon, water, and energy are central to Earth system functioning, yet their sensitivities to environmental variability remain poorly constrained across biomes and climates. Here, we analyzed ≥ 5 years of eddy covariance data from 87 AmeriFlux sites (964 site-years) spanning six vegetation types and a broad range of climatic conditions to examine the controls and multi-year trends of gross primary productivity (GPP), evapotranspiration (ET), water-use efficiency (WUE), and the Bowen ratio. We trained boosted regression tree ensembles with environmental (air temperature, vapor pressure deficit, soil water content, atmospheric CO2, radiation, wind speed) and temporal (month, year) variables …