Digital Commons Network^™

Discovering Drug-Like Compounds By Targeting Protein-Protein Interactions Using A Yeast-3-Hybrid System, Chesley C. Blake

Senior Theses

Protein-protein interactions are important targets in cancer biology as they can make historically “undruggable” proteins viable drug targets. However, the current approach to targeting protein-protein interactions relies on the use of small molecule drugs, which have low efficiencies as they must cover a large surface area of the interaction. Further, traditional drug therapies often lead to off-target toxicity, limiting therapeutic specificity. The objective of this project is to develop a selection system in yeast to identify short peptide sequences that can disrupt protein-protein interactions specific to cancer cells. Following proof of principle and development of the AH109 yeast strain having …

Evaluating The Impact Of Social Determinants Of Health On Outcomes Of Type Ii Diabetes In South Carolina, Alexander G. Downs

Senior Theses

Type II diabetes mellitus (T2DM) represents a significant public health burden in South Carolina, where 13.5% of adults are affected, surpassing the national rate of 12%. This integrative literature review examines the social determinants of health most strongly associated with T2DM morbidity and mortality in South Carolina, including race and ethnicity, socioeconomic status, rural or urban residence, educational attainment, healthcare access, and food insecurity. Evidence drawn from peer-reviewed studies, epidemiological reports, and state health data reveals that African American, rural, and low-income populations bear a disproportionate share of the diabetes burden in the state. These disparities arise through multilevel mechanisms …

Performing Politics: Contextual Shifts In Identity Expression Amongst Ingroup And Neutral Settings, Elsa Geriane Johnson

Senior Theses

Increased political divisiveness and the rise of social media have contributed to a widening gap between individuals situated on the political left and right. However, prior research has not determined whether individuals express their political identities similarly when among in-group members versus in more neutral spaces.

Individuals were observed in politically charged settings and in politically neutral settings to determine how the expression of political identities differs when among in-group members versus when discussing politics in classrooms. Data was analyzed using a systemic thematic process through the lens of social identity theory. Findings supported the hypothesis that political identities are …

Crystallization And Utility Of Brominated Phenylethynylene Bis-Urea Macrocycles, Paras Srivastava

Senior Theses

Macrocycles are large, cyclic molecules with central cavities that can encapsulate other molecules and that have uses in supramolecular chemistry. The Shimizu group has previously synthesized Macrocycle 1, a phenylethynylene bis-urea macrocycle that crystallizes in a columnar form, enabling its utility as a host in host-guest systems. Reactions within these systems can be used to modify stereospecificity, kinetics, and other physical properties. Previously, photodimerization reactions between coumarins and chromones have been studied in systems of Macrocycle 1, resulting in the improved specificity of photodimerization products. Herein, we apply a dynamic covalent chemistry (DCC) strategy to synthesize Macrocycle 1 and its …

Cell-Free Mitochondrial Dna (Mtdna) Triggers Vascular Dysfunction Via Toll-Like Receptor 9 (Tlr9)-Dependent Activation Of Inflammasomes, Mohin Amin

Senior Theses

Hypertension is the leading global risk factor for mortality and is closely associated with vascular inflammation and dysfunction. Damaged mitochondria release cell-free mitochondrial DNA (cf-mtDNA), which activates toll-like receptor 9 (TLR9). The binding of TLR9 to mtDNA activates the NLRP3 inflammasome pathway, promoting the release of pro-inflammatory cytokines via gasdermin D (GSDMD), therefore worsening inflammation. However, the mechanisms linking mitochondrial injury to inflammation-induced vascular dysfunction remain unclear. We hypothesize that cf-mtDNA triggers TLR9-dependent NLRP3 inflammasome activation contributing to vascular and endothelial dysfunction. To assess that, adult male C57BL/6 were exposed to 28 consecutive days of chronic unpredictable stress (CUS) or …

April 2026 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

Social Emotional Learning In A High School Setting, Aaron Stack

School of Education and Leadership Student Capstone Projects

This project examined the capstone question: How can one design and implement a Social Emotional Learning (SEL) program for high school students? This topic is important as more and more students are exhibiting less desirable behaviors inside the classroom. While exploring this question, several key findings emerged. First, SEL programming in a high school setting may have a positive impact on students’ academic performance and behaviors. Second, there is no clear distinction between the effectiveness of the program as long as the SEL ideas are consistently explored. Based on these two findings, an SEL program was developed for high school …

Plasmoid Vortex System Retrofit A Sustainability And Efficiency Study On Internal Combustion Engines, Walker Hall

Doctoral Dissertations and Master's Theses

The thesis addresses the persistent inefficiency and environmental degradation caused by internal combustion engines in modern vehicles, a major issue as the automotive industry faces increasing pressure to reduce fuel consumption and greenhouse gas emissions. Internal combustion engines, which power most cars today, convert only about 20-30% of fuel energy into useful work, with the remainder lost as heat and exhaust waste, including carbon monoxide (CO), carbon dioxide (CO₂), hydrocarbons (HC), and nitrogen oxides (NOx). This inefficiency contributes to global carbon emissions, with transportation accounting for approximately 29% of U.S. greenhouse gases in 2021 [1]. As regulatory standards tighten (e.g., …

Low-Complexity Structured Neural Networks And Their Usage In Image And Signal Processing, Adam Kuzmicki

Doctoral Dissertations and Master's Theses

Conventional neural networks face significant challenges due to high computational costs, large parameter counts, and reliance on backpropagation, which restricts their application in resource-constrained and real-time settings. To address these challenges, this thesis proposes three structured neural network (NN) architectures grounded in the theories of sparse and self-contained factorizations of transforms, with applications to image compression, reconstruction, classification, encryption, and also adaptive wideband multi-beam beamforming. The first neural network architecture, named DCTrix-Net, replaces conventional spatial con- volution with highly sparse factorization of the discrete Cosine transform (DCT) complemented by Toeplitz-structured weight initialization, achieving at least 97% FLOP reduction over CNNs, …

Who Then Can Be Saved? A Discussion Of Views Within The Christian Tradition Concerning The Salvation Of The Non-Christian, Logan A. Davis

Honors Theses

This thesis argues that, contrary to popular conception, the Christian Tradition is not strictly exclusivist in its understanding of salvation or in its assessment of the fate of the non-Christian but rather displays a rich diversity of views. Both the Christian Tradition and the Christian scriptures are characterized by a certain ambiguity on this issue; although a definitive answer may exist, it is not easily identifiable. Given this ambiguity, the study presents a representative spectrum of theological positions within the Christian Tradition and analyzes their respective treatments of the salvation of the non-Christian. In doing so, it seeks to provide …

Global Trends In Bioterrorism And Biosecurity Research Publications (1997–2025): A Scopus Bibliometric Analysis, Festus Mulakoli, Samuel Gesaka, John Mbataru

School of Nursing & Midwifery, East Africa

Introduction: Bioterrorism and biosecurity preparedness are critical pillars of global public health protection and resilience of health systems worldwide. Although this field has grown over the past few decades, there remains limited clarity on how research efforts have evolved and where critical gaps persist, particularly regarding global collaboration and emerging biological threats. To address this, we conducted a bibliometric analysis to map publication trends, influential contributors, and collaboration networks in bioterrorism and biosecurity from 1997 to 2025. This study analyzed global research output, collaboration, and thematic evolution in bioterrorism and biosecurity and identified gaps relevant to preparedness and policy. …

How Media Framing Impacts Juror Bias In A Fictional Criminal Case, Teah Sharon Swartzon

Journalism

This study examines how media framing influences juror bias among college-aged students when evaluating a defendant's guilt in a fictional criminal case. Utilizing framing theory, the research explores whether biased news coverage can shape perceptions of a defendant's guilt before trial.

Participants, consisting of students at California Polytechnic State University, aged 18-22, were asked to read two news articles about a fictional criminal case. One framed the fictional defendant as guilty, while the other framed him as innocent. Both articles were generated using the Artificial Intelligence Platform, Claude.

Data was collected in a survey where participants indicated whether they believed …

Advancing Paleontologic Mapping: A Gis And Drone Photogrammetry Approach To The Lance Formation Beds Of Glenrock, Wyoming, William H. Steelman, Monika Angner, Norman S. Levine, W S. Persons

The Compass: Earth Science Journal of Sigma Gamma Epsilon

Small museums and volunteer-driven field programs often lack the resources required for detailed geological mapping, limiting the stratigraphic data associated with their fossil collections. To address this challenge, an affordable and replicable mapping workflow was developed that combined drone-based photogrammetry, GIS analysis, and targeted structural measurements using the Glenrock Exposure of the Lance Formation as a study site. The resulting 3D outcrop models, bedding-plane reconstructions, and 750-m-thick stratigraphic column provide the first comprehensive spatial framework for 35 fossil quarries curated by the Glenrock Paleon Museum. The results reveal tightly clustered fossil-bearing horizons, a long interval lacking preservation, and a notable …

Sigma Gamma Epsilon Student Research Poster Session, Geological Society Of America Annual Meeting 2025, San Antonio, Texas, Usa, Scott R. Beason, Lee S. Potter

The Compass: Earth Science Journal of Sigma Gamma Epsilon

The Society of Sigma Gamma Epsilon (SGE) sponsors a poster session at every annual meeting of the Geological Society of America. The 37th SGE undergraduate research poster session took place during the 2025 Geological Society of America Annual Meeting (GSA Connects) in San Antonio, Texas, USA, on Monday, October 20, 2025. Fifty-seven (57) posters were presented in Exhibit Hall 1 at the Henry B. Gonzalez Convention Center between 8:30 AM and 5:30 PM at the poster session, with authors present between 9:00 AM and 11:00 AM. Titles, authors (italics for the presenting author), affiliations, and abstracts for each poster are …

Dental Insurance Status Among Formerly Incarcerated Older Adults, Alexander Testa, Rafael Samper-Ternent, Dylan B Jackson, Kyle T Ganson, Vahed Maroufy, Jason M Nagata, Ana C Neumann

Faculty, Staff and Student Publications

Formerly incarcerated individuals have poorer oral health and less frequent dental care utilization than the general population. However, prior work has overlooked the relationship between prior incarceration and disparities in dental insurance coverage. Using data from the Health and Retirement Study (n = 11,638), findings from multiple logistic regression analyses demonstrate that formerly incarcerated older adults are significantly less likely to have dental insurance coverage (odds ratio [OR] = 0.745, 95% confidence interval [CI] = 0.608, 0.912). After accounting for the income-to-poverty ratio, this association was no longer statistically significant. Analyses using the Karlson-Holm-Breen method demonstrated that approximately 45% of …

Robo2 Variants Associated With Atrial Septal Defect Define A Novel Regulatory Element, Seong Won Kim, Michael Parfenov, Laura Rodriguez-Murillo, David A Conner, Arun Sharma, Inga Peter, Feng Xiao, Olivia Layton, Angela Tai, Tarsha Ward, Lauren K Wasson, Joshua M Gorham, Erica Mazaika, Valentina N Lagomarsino, Tracy L Young-Pearse, Elizabeth Goldmuntz, Hiroko Wakimoto, A J Agopian, David M Mckean, Steven R Depalma, William T Pu, Christine E Seidman, Bruce D Gelb, Jonathan G Seidman

Faculty, Staff and Student Publications

Background: Atrial septal defects (ASDs) are a prevalent type of congenital heart disease. Previous GWAS (Genome-Wide Association Studies) have identified common variants associated with ASDs, though their mechanisms remain unknown. We aimed to expand insights into the architecture of common variants associated with ASD risk and elucidate functional mechanisms.

Methods: We conducted a GWAS using isolated ASD cases and healthy controls and replicated findings in an independent cohort. We examined epigenetic marks within this ASD locus in human induced pluripotent stem cell-derived cardiomyocytes and fetal human hearts. We characterized the consequences of deletions introduced by CRISPR-Cas9 mutagenesis of human induced …

Developing Scenario-Based Strategies For Health, Climate, And Environmental Preparedness: The One Health, One Earth Approach, Azar M Abadi, Kyle D Brumfield, Moiz Usmani, Gemma Jiang, T C Chakraborty, Yuzhou Wang, Zhijie Zhou, Cenlin He, Minghao Qiu, Jennifer D Stowell, Douglas Fritz, Sunil Kumar, Qiang Guo, Ying Xiong, Georgia Destouni, Qian Xiao, Xindi C Hu, Kelvin C Fong, Yun Hang, John Nielsen-Gammon, Rima Habre, Jennifer R Bratburd, Christopher W Tessum, Antarpreet Jutla, Rita R Colwell, Gabriel M Filippelli, Thanh H Nguyen

Faculty, Staff and Student Publications

Climate change amplifies many threats to human health. Despite advances in understanding climate change dynamics and impacts, there remains a critical gap in translating scientific knowledge into equitable, and community‐driven health interventions. The inaugural One Earth, One Health workshop sought to explore this gap through human‐centered design exercises involving interdisciplinary researchers from climate and Earth sciences, engineering, epidemiology, microbiology, and environmental health. Although participants did not co‐develop solutions with affected communities, they used stakeholder role‐playing to guide ideation and lay groundwork for actionable plans. Through these methods, participants identified community needs and proposed prototype solutions to alleviate health threats …

Effective Support Services For Black-African International Students, Amy V. Rutledge

Doctor of Education (Ed.D)

Currently, 1.5 million F-1 and M-1 students are enrolled in U.S. institutions of higher education (IHEs; U.S. Immigration and Customs Enforcement, 2025). Although support services for international students are improving, substantial gaps remain in helping these students transition to the next phase of life (Weiner & Ghazarian, 2024). This transcendental phenomenological study examined the lived experiences of six recently graduated Black African international students (BAISs) to identify effective support services for graduate programs, licensure, or legal employment. Participants were recruited through snowball sampling for interviews, which were analyzed using descriptive coding (yielding 61 codes) and thematic analysis (producing six themes). …

Patenting The Unexpected, Sean B. Seymore

Vanderbilt Law School Faculty Publications

Unexpected discoveries have transformed human existence. They’ve revolutionized science and spawned entire new fields of research. While unexpected discoveries seem inventive and worthy of patent protection, they don’t formally align with traditional patent theory. The bedrock principle that an invention begins with the conception of an idea in the inventor’s mind and ends with implementation doesn’t apply to unexpected discoveries. This misalignment is most acute for pharmaceuticals, where the discovery of new uses for old drugs has tremendous social and economic importance. Since a drug can inherently treat multiple conditions in a patient—even those unknown to the patient, doctor, or …

Comparing Student Performance And Perceived Learning Between In-Person And Online Sections Of An Undergraduate Human Anatomy And Physiology Laboratory Course, Madeline M. Knox

Honors Thesis

Online laboratory courses are increasingly common in undergraduate science education, but their effectiveness relative to in-person laboratories remains unclear. This study compared students’ academic performance and perceived learning outcomes between online and in-person anatomy and physiology laboratory sections at the University of South Dakota. Final course grade distribution between the two modalities across three semesters (n = 158 in-person and n = 312 online) was analyzed, and student perceptions of cognitive, affective, and psychomotor learning were assessed using the CAP Perceived Learning Scale instrument in post-course surveys (n = 81 in-person and n = 37 online). Grade distributions …

Leveraging Aspiring And Inspiring Mentorship Relationships To Promote Stem Persistence, Rayann K. Hoppe

Honors Thesis

While several mentorship interventions for STEM students already exist, persistence and retention in STEM fields remain relatively low. Additionally, there is limited research examining the intersections between aspiring (upward) and inspiring (downward) mentorship roles.

This article aims to address these gaps by examining existing literature and mentorship frameworks, with a focus on how mentorship dynamics influence STEM persistence. Two principal findings emerge from the literature: (1) effective mentorship should be conceptualized as an interconnected ecosystem rather than a hierarchical structure, and (2) the intersection of aspiring and inspiring roles contributes to the development of identity, self-efficacy, and a sense of …

Ecological Studies Of Wolves On Isle Royale, Sarah R. Hoy, Rolf O. Peterson, John A. Vucetich

Ecological Studies of Wolves on Isle Royale

Annual Report 2025-2026

Gamma Sigma Delta, Nebraska Chapter Newsletter, Issue #69 Spring 2026

Gamma Sigma Delta, Nebraska Chapter: Newsletters

President's message, Dustin Loy

Undergraduate Scholarship Awards

2026 Chapter Officers and Committees

Faculty Awards

Membership info and dues form

Grad Student Scholarship

Award of Merit

NU Foundation Fund

New Initiates

Save the Date

In Memoriam:
Kara Daye Heideman (March 31, 1980-December 11, 2025)
L. Dale Van Vleck (June 11, 1933-December 23, 2025)
James (Jim) Eugene Specht (September 12, 1945-February 13, 2026)
Irvin Thomas Omtvedt (June 12, 1935-April 6, 2026)
Fayrene L. Hamouz (June 6, 1946-April 8, 2026)
Robert L. Raun (April 22, 1928-April 22, 2026)

Evolution Of Antibiotic Responses During Chronic P. Aeruginosa Infections In The Human Lung, David Frank Ritz

Dartmouth College Ph.D Dissertations

Typical antibiotic susceptibility testing (AST) of microbial samples is performed in homogeneous cultures in batch environments, which does not account for the highly heterogeneous and dynamic nature of antibiotic responses. The most common mutation found in P. aeruginosa lineages evolved during chronic cystic fibrosis infections in the human lung, a loss of function of repressor MexZ, increases basal levels of multidrug efflux MexXY, but does not increase resistance by traditional minimal inhibitory concentration (MIC) assays. Here, we use single cell microfluidics to show that P. aeruginosa’s response to aminoglycosides is highly heterogeneous, with only a subpopulation of cells surviving exposure. …

Transfusion In Transit: A Decade Of Prehospital Blood Transfusion In Pediatric Trauma, Krysta M Sutyak, Eunise C Chen, Lea Mock, Rudolfo Cabrera, Jeannette M Joly, Kuojen Tsao, Bryan A Cotton, David E Meyer, Charles S Cox, Kevin P Lally, Natalie A Drucker

The Brown Foundation: Institute of Molecular Medicine

Background: Prehospital blood transfusion improves mortality in adults, with limited evidence in children. This study describes prehospital blood transfusion in pediatric trauma patients and the impact on shock index, pediatric adjusted (SIPA).

Methods: This study is a retrospective cohort study of trauma patients younger than 18 years who received blood transfusions during helicopter transport to a Level 1 pediatric trauma center from 2011 to 2023. Primary outcome was change in SIPA at time of emergency department (ED) arrival with prehospital transfusion. Secondary subgroup analysis was performed based on transport origin.

Results: Of 137 patients, 58% (80 of 137 patients) were …

Affinity-Optimized Trop2 Antibodies Support Potent Antitumor Activity In Antibody-Drug Conjugates, Aiko Yamaguchi, Junping Hong, Leike Li, Kiyotaka Kobayashi, Chisato M Yamazaki, Summer Y Y Ha, Yasuaki Anami, Wei Xiong, Junquan Liu, Zhiqiang An, Ningyan Zhang, Kyoji Tsuchikama

The Brown Foundation: Institute of Molecular Medicine

Background: Trophoblast cell surface antigen 2 (TROP2) is frequently overexpressed in epithelial tumors and is associated with poor prognosis, making it an attractive therapeutic target. Antibody-drug conjugates (ADCs) directed against TROP2 show clinical benefit, but expression in normal tissues such as skin raises concerns about on-target, off-tumor toxicity. Strategies that improve antitumor efficacy without increasing toxicity are needed.

Methods: Using an in-house phage library, we identified and characterized a novel fully human monoclonal antibody recognizing a unique conformational epitope of TROP2 with reduced binding affinity. This antibody was engineered into homogeneous ADCs carrying auristatin and/or duocarmycin payloads. Comparative studies with …

Telomerase Knockout In Myeloid Cells Predisposes Mice To Foam Cell Formation, Dyslipidemia, Lung Fibrosis, And Cardiac Dysfunction, Zhanguo Gao, Yongmei Yu, David Wiggins, Eva M Sevick-Muraca, Mikhail G Kolonin

The Brown Foundation: Institute of Molecular Medicine

Aging-associated changes in myeloid cells are incompletely understood. One of the culprits of aging is the downregulation of the Tert gene coding for the catalytic subunit of telomerase. Studies of mouse models with Tert knockout (KO) in specific cells have revealed the importance of the telomere-independent noncanonical function of TERT in supporting mitochondrial metabolism and protection from cell senescence. To investigate the role of TERT in myeloid cells (MCs), we analyzed mice with Tert KO in the LysM+ lineage, indelibly labeled with membrane green fluorescent protein (mG). Macrophage numbers and properties in various organs were compared. Changes in the vasculature, …

2026 April, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for April of 2026.

Evaluating The Environmental Parameters Impacting Spawning Movement Of Gulf Sturgeon (Acipenser Desotoi) In The Bouie River System., Olivia St. Germain

Honors Theses

The anadromous Gulf Sturgeon (Acipenser desotoi) is federally listed as “threatened” and is natal to seven rivers from Louisiana to Florida. Only one spawning reach for Gulf Sturgeon natal to the Pascagoula River has been verified via the collection of eggs and larvae; a reach of the lower Bouie River. This reach is anthropogenically modified by four gravel mining formations, hereafter referred to as pits. The greater depths associated with this area have prompted previous researchers to suggest that Gulf Sturgeon may over-summer in pit formations instead of migrating to downstream holding areas in the Pascagoula River after spawning. The …

Tfeb Degradation Is Regulated By An Ikk/Β-Trcp2 Phosphorylation-Ubiquitination Cascade, Yan Xiong, Jaiprakash Sharma, Meggie N Young, Wen Xiong, Ali Jazayeri, Karl F Poncha, Ma Xenia G Ilagan, Qing Wang, Bei Gao, Hui Zheng, Nicolas L Young, Marco Sardiello

Center on Aging Staff Publications

Transcription factor EB (TFEB) is a master regulator of lysosomal biogenesis and cellular clearance pathways. TFEB activity is tightly controlled by multiple post-translational mechanisms, but the exact molecular mechanism controlling its stability has remained elusive. Here, we identify the IκB kinase (IKK) complex as a key regulator of TFEB protein stability through a phosphorylation-ubiquitination cascade. A high-content kinase inhibitor screen reveals that IKK inhibition increases TFEB protein levels, and genetic ablation of IKK components increases TFEB stability, upregulates lysosomal genes, and enhances lysosomal biogenesis and degradative capacity. Mechanistically, we show that IKK phosphorylates TFEB on a cluster of serine residues …