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Academic Libraries As A Platform For Indigenous And Agricultural Knowledge Sharing In Rural Communities: A Conceptual And Review-Based Approach, Jenifer Yesmin Laskar, Pradip Kumar Singha

Library Philosophy and Practice (e-journal)

Agriculture and traditional knowledge are the roots of rural economy, particularly in biologically sensitive areas with diverse cultures. Preserving traditional knowledge in terms of local farming practices is an activity that is generally associated with cultural practices in these areas. The potentiality of academic libraries in terms of bridging roles for dissemination, curation, and sharing of Indigenous knowledge as well as Agriculture knowledge in the respective areas remains largely overlooked. It is an attempt to explore, indicate, and address through the theoretical approaches based upon an understanding of library science concepts, Indigenous studies, community development, sustainability studies, the roles of …

From Ancient Harmony To Modern Sustainability: Assessing The Coupling Of Taoist “Harmony Between Humanity And Nature” With Esg And Its Impact On Firm Innovation And Performance, Biyi Wang

Dissertations and Theses Collection (Open Access)

Against the backdrop of intensifying global ecological crises, the ESG evaluation system has become a core metric for corporate sustainable development worldwide. However, the Western-dominated ESG system lacks crucial cultural dimensions in its application within Chinese corporate practices. The ecological wisdom embedded in the Taoist concept of “Harmony between Humanity and Nature” offers a significant philosophical foundation for the ESG localization. Extant research has focused on the influence of Confucian culture on ESG, with insufficient exploration of the modern managerial value of “Harmony between Humanity and Nature”. A scientific coupling framework linking this concept with ESG indicators has yet to …

Influence Of Gut Microbiota On Response To Immune Check Point Inhibitors In Masld Patients With Hcc: Unraveling The Connection, Mazen Elsheikh, Mohamad Ali Ibrahim, Sherry Fares, Megha Bhongade, Karim Adhem, Ximena I Ramirez-Morales, Ahmed O Kaseb, Joseph Petrosino, Manal M Hassan, Prasun K Jalal

Faculty, Staff and Students Publications

Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction-associated liver disease (MASLD), exhibit resistance to ICI therapy. Studies have revealed that the presence of specific gut bacteria, such as Akkermansia, Bifidobacterium, and Lachnoclostridium, is associated with improved outcomes with ICI-treated HCC patients. Conversely, the overgrowth of bacteria like Enterobacteriaceae is linked to resistance to therapy. This review investigates the role of gut microbiota in shaping immune checkpoint inhibitor responses in MASLD-related hepatocellular carcinoma, focusing on how dysbiosis may …

Leveraging Untargeted Metabolomics In Combination With Machine Learning To Uncover Novel Insights Into Bladder Cancer, Abu Hena Mostafa Kamal, Vasanta Putluri, Tanmay Gandhi, Chandra Shekar R Ambati, Chandra Sekhar Amara, Karthik Reddy Kami Reddy, Meredith Lauren Spradlin, Amrit Koirala, Sachin B Jorvekar, Sandra L Grimm, Dexue Fu, Krishna Parsawar, Felice De Jong, Chris Beecher, Subrata Sen, Seth P Lerner, M Minhaj Siddiqui, Yair Lotan, Livia S Eberlin, Arun Sreekumar, Cristian Coarfa, Nagireddy Putluri

Faculty, Staff and Students Publications

Background

Untargeted metabolomics has emerged as a powerful approach to uncover metabolic dysregulation associated with cancer progression. When integrated with a machine learning strategy it facilitates the discovery of key metabolic pathways and predictive biomarkers with high diagnostic and prognostic value.

Methods

In this study, we employed liquid chromatography coupled to high-resolution Tribrid Orbitrap mass spectrometry to perform comprehensive metabolic profiling of bladder cancer (BLCA) as well as predict invasiveness of the disease.

Results

By leveraging both in-house retention time-based MS/MS spectral libraries and commercial databases, we robustly identify over 2000 metabolites. In addition, this platform allows identification of novel …

Widespread Distribution Of Alu/Alu-Mediated Genomic Rearrangement Predisposing To A Broad Range Of Mendelian Disease And Cancer In Human Populations, Ruizhi Vince Duan, Haowei Du, Shruti Pande, Ahmed K Saad, Meryem M Atik, Minal Jamsandekar, Karen J Coveler, Zain Dardas, Shalini N Jhangiani, Jennifer E Posey, Richard A Gibbs, James R Lupski

Faculty, Staff and Students Publications

Background

Genome-wide distributions of Alu elements contribute to a broad range of structural variants (SVs) through Alu/Alu-mediated genomic rearrangement (AAMR). Yet, the prevalence and characteristics of AAMR on the human genome and its scale in generating pathogenic SVs remain poorly understood.

Methods

We established a disease-focused, AAMR-SV dataset and a control dataset to comprehensively delineate the genomic landscape of Alu mutagenesis. The disease-focused dataset included 407 published pathogenic AAMR-SV alleles in 115 known genes for Mendelian disorders or traits through a literature survey. A control dataset was collected from short-read genome sequencing analyses of 100 randomly selected, healthy individuals. …

Fronto-Cerebellar Features Associate With Cognitive Dysfunction In Childhood-Onset Systemic Lupus Erythematosus, Hanne Van Der Heijden, Gabrielle Alonzi, Amanda Cao, Raquel Van Gool, Merve Koç Yekedüz, Lise Vrolix, Itamar Ronen, Vanessa Rameh, Kyle Mcbrearty, Aditi Deokar, Robert P Sundel, Eyal Muscal, Joseph Gonzalez-Heydrich, Andrea Knight, Joyce C Chang, Jaymin Upadhyay

Faculty, Staff and Students Publications

Objective: Cognitive dysfunction (CD) is a prevalent symptom in childhood-onset systemic lupus erythematosus (cSLE). This study aimed to investigate the neurobehavioral basis of CD in cSLE.

Methods: Patients with cSLE (N=20) and age- and sex-matched healthy controls (HCs, N=20) completed questionnaires and multiple neurocognitive tests. The Systemic Lupus Erythematosus Disease Activity Index 2000 and laboratory markers were used to monitor patients' clinical status. Neuroimaging assessments included functional near-infrared spectroscopy (fNIRS), functional magnetic resonance imaging (fMRI), and structural MRI.

Results: cSLE patients demonstrated moderate disease activity with high inflammation and immune dysregulation, alongside low medication adherence. Relative to HCs, cSLE patients …

Novel Variants Identified In Families With Snx27 -Related Neurodevelopmental Disorder, Aiding In Characterizing Its Genotypic And Phenotypic Spectrum, Tayyaba Shan, Abrar Hussain, Anushree Acharya, Mulazim Hussain, Yumei Li, Hafiz Muhammad Jafar Hussain, Kiran Afshan, Suzanne M Leal, Rui Chen, Asif Mir, Isabelle Schrauwen, Sabika Firasat

Faculty, Staff and Students Publications

Background:

Sorting Nexin 27 (SNX27), a key regulator of synaptic receptor trafficking and endosomal recycling, has been implicated in maintaining synaptic homeostasis and cognitive function. To date, variants in SNX27 have been reported in a small number of patients across three publications with severe neurodevelopmental phenotypes. However, the genetic and functional landscape of SNX27-related disorders remains poorly understood, and further evidence is needed to confirm its association with disease and to better delineate the associated phenotype.

Methods and Results:

Two unrelated Pakistani families with a total of five affected individuals segregating a neurodevelopmental disorder were investigated via exome …

Non-Invasive Intracranial Pressure Estimation In The Intensive Care Unit: Narrative Review Of Methods And Clinical Applications, Edoardo Picetti, Daniele Guerino Biasucci, Elisa Gouvea Bogossian, Sérgio Brasil, Danilo Cardim, Marek Czosnyka, Daniel A Godoy, Gregory W J Hawryluk, Mohammad I Hirzallah, Frank A Rasulo, Carla Bittencourt Rynkowski, Andres M Rubiano, Fabio Silvio Taccone, Chiara Robba

Faculty, Staff and Students Publications

Despite invasive methods are the gold standard for intracranial pressure (ICP) measurement, several non-invasive techniques (nICP) have been proposed as surrogate, although their use remains insufficiently recognized in clinical practice. These include transcranial Doppler blood flow velocity  assessment (arterial or venous), optic nerve sheath diameter (ONSD), automated pupillometry, measurement of skull expansion and compliance, brain imaging, double-depth ophthalmic artery blood flow velocity, and ultrasound time-of-flight. The main limitations of all indirect methods are calibration and zeroing, which constrain the absolute accuracy of non-invasive ICP monitoring. For transcranial Doppler-based methods, the 95% limits of agreement are approximately ± 7-15 mmHg, while …

Efficient In Vivo Pharmacological Inhibition Of Δfosb, An Ap-1 Transcription Factor, In The Brain, Sean Mcneme, Anil Kumar, Yun Young Yim, Brandon W Hughes, Corey St Romain, Yi Li, Ashwani Kumar, Qichao Bao, Molly Estill, Shanghua Fan, Nadeen Takatka, Earnest P Chen, Matthew Rivera, Haiying Chen, Alfred J Robison, Mischa Machius, Stephen J Haggarty, Jeannie Chin, Eric J Nestler, Jia Zhou, Gabby Rudenko

Faculty, Staff and Students Publications

ΔFOSB, an unusually stable member of the AP-1 family of transcription factors, mediates long-term maladaptations that play a key role in the pathogenesis of drug addiction, cognitive decline, dyskinesia, and several other chronic neurological and psychiatric conditions. We have recently identified that 2-phenoxybenzenesulfonic acid-containing compounds disrupt the binding of ΔFOSB to DNA in vitro in cell-based assays, and one such compound, JPC0661, disrupts ΔFOSB binding to genomic DNA in vivo in the mouse brain with partial efficiency. JPC0661 binds to a groove outside of the DNA-binding cleft of the ΔFOSB/JUND bZIP heterodimer in a cocrystal structure. Here, we generated a …

Truth Or Consequences, Jack Galati

Yalobusha Review

No abstract provided.

Full Issue, Journal Editors

Yalobusha Review

No abstract provided.

Market Forces, Niall Kaye

Yalobusha Review

No abstract provided.

Nearest Exit, Dylan Bassett

Yalobusha Review

No abstract provided.

Laser-Assisted New Attachment Procedure: A Review, Divya Khanna B.D.S., M.D.S.

The New York State Dental Journal

Periodontal treatment modalities have evolved substantially to evidence-based minimally invasive treatment options. Lasers have proved to be an effective tool by providing a myriad of benefits and advantages while eliminating many of the negative sequelae that have been historically associated with conventional pocket elimination surgery. Laser-assisted new attachment procedure (LANAP) is a well-defined treatment protocol that has been validated with human histology and has demonstrated both short- and long-term success. LANAP has proven to be an effective, safe and predictable treatment option for achieving regeneration and new attachment formation, leading to favorable clinical outcomes, improved patient compliance and acceptability.

Final Project: Nutrition And Human Disease, Sam Newberry Ph.D.

School of Arts & Sciences

This assignment is made up of a series of smaller assignments that were developed by SUNY Geneseo Professor Sam Newberry during the spring 2026 semester.

Learning Objectives

• Identify and demonstrate understanding of audience needs
• Identify nutritional issues associated with human disease
• Clear communication of information via an Infographic
• Proper utilization of scholarly sources of information

Biol 210: Nutrition (Syllabus), Sam Newberry Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Sam Newberry during the spring 2026 semester.

Course Learning Objectives:

Students who are active participants and complete course requirements will be able to: 

1. Demonstrate familiarity with nutrients, their food sources, their functions, and signs and symptoms of deficiency or excess.
2. Demonstrate familiarity with biological, psychological, social and cultural factors that influence human diet and nutrition.
3. Describe and explain in class discussion and on exams the relationship between diet and health, particularly for selected public health issues.
4. Demonstrate familiarity with nutritional guidelines used in the United States, and the challenges of establishing such …

Anth 322: Anthropology Of Borderlands (Syllabus), Jennifer R. Guzmán Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Jennifer Guzmán during the spring 2026 semester.

Course Learning Objectives

By participating in this course, you will:

• Gain familiarity with anthropological literature concerning borders, migration, immigration enforcement, and the U.S.-Mexico border
• Explore historical and current immigration policies and their impacts on communities across the borderlands and throughout the Americas
• Learn from people directly affected by migration, including migrants and others who live in the borderlands, and with advocates for migrant justice
• Build connections with people and organizations that are working on humanitarian and migrant justice issues.
• Think critically and intersectionally about solutions …

Career Readiness In Developmental Biology Module, Travis Bailey Ph.D.

School of Arts & Sciences

This set of activities were developed and modified by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.

Biol 454: Developmental Biology (Syllabus), Travis Bailey Ph.D.

School of Arts & Sciences

This syllabus was developed by SUNY Geneseo Professor Travis Bailey in the spring 2026 semester.

Learning Outcomes-Students will:

• Understand the methods scientist use to explore the genetic, cellular, and tissue control of development.
• Compare and contrast developmental strategies of model organisms.
• Read primary literature critically and explain strengths and weaknesses.
• Test hypotheses with self-designed experimentation, measurement and data collection, evaluation of evidence, and employment of mathematical analysis.
• Relate discoveries from model animals to human conditions.
• Communicate findings orally and in writing.
• Integrate multiple bodies of knowledge with their personal experience by asking meaningful questions about real-world problems
• Apply skills, theories, …

The Role Of Magnesium Supplements In The Management And Prevention Of Headache Disorders, Tatum Schroeder

Libraries Undergraduate Research Award (LURA) Winners

Much of the global population suffers from headache disorders like migraine. Because there are so many triggers and unknown explanations for migraine, it can be hard to find effective treatments for it. There are some studies that point to inflammation as either a cause or result of headache disorders; therefore, it is natural that we should explore the possibility of inflammation reducing factors when considering treatment options. The factor being explored in this review is magnesium supplementation, which has been shown to reduce inflammation by decreasing the amount of calcitonin-gene-related-peptide (CGRP) in circulation. There is a clear link between migraine …

Heroes Of Medicine In The Rio Grande Valley: Documentary Interview With Dr. Nelson Mata, Nelson Mata, Aidan Mata

Heroes of Medicine in the Rio Grande Valley

Dr. Nelson Mata is a physician who has conducted his practice of internal medicine for 32 years. He has always been fascinated by biology, and when he was only 10 years old, he asked for a microscope for Christmas. Raised in a family of three physicians, he got to see firsthand what it means to help others. Originally living in Dominican Republic where he studied medicine, he went to fulfill his residency program in New York. Later, he began his practice here in the Rio Grande Valley where doctors who could speak Spanish were needed. He saw it as an …

Heroes Of Medicine In The Rio Grande Valley: Documentary Interview With Cynthia M. Bueno, Pa-C, Cynthia M. Bueno, Jessica N. Martinez Guzman

Heroes of Medicine in the Rio Grande Valley

Cynthia M. Bueno, PA-C, is a dedicated physician assistant practicing family medicine at Valley Medical Arts Clinic, where she serves patients across the Rio Grande Valley with a strong commitment to compassionate, patient-centered care. She earned her Bachelor of Science in Biology with a minor in Chemistry from The University of Texas-Pan American in 2015 and later completed her Master of Physician Assistant Studies from The University of Texas-Pan American in 2018. Since then, she has dedicated her career to improving the health of her community through attentive and empathetic care.

In this mini documentary, Heroes of Medicine: Compassion in …

Heroes Of Medicine In The Rio Grande Valley: Documentary Interview With Gustavo F. Olivares, Gustavo F. Olivaes, Isabel A. Suarez

Heroes of Medicine in the Rio Grande Valley

Gustavo Olivares, PA-C, is a dedicated Physician Assistant at All Children’s Pediatric Clinic in McAllen, Texas, where he has provided care for over 21 years. In his role as a clinician, he is responsible for diagnosing patients, conducting assessments, developing treatment plans, making referrals, interpreting laboratory data and imaging studies, and prescribing medications. He earned his degree from the University of Texas–Pan American (UTPA) through its Physician Assistant program. His journey into the profession began while initially pursuing medical school, where he completed several interviews but ultimately chose an alternative path. His inspiration to become a physician assistant stemmed from …

Dna Methylation Of Slc6a4 And Nr3c1 In Term And Preterm Infants: A Pilot Study Of Nicu-Associated Stress, Kathryn J. Malin, Yvette P. Conley, Aleigha Barry, Rosemary White-Traut

College of Nursing Faculty Research and Publications

Background: Preterm infants requiring prolonged hospitalization in the neonatal intensive care unit (NICU) are often exposed to early-life stress, which may contribute to long-term health consequences. Epigenetic markers, particularly DNA methylation (DNAm) of stress-related genes such as SLC6A4 and NR3C1, have been identified as potential biomarkers of early-life stress. Limited research has compared DNAm patterns between term and preterm infants or examined associations between NICU-related stress and DNAm in preterm populations. Objectives: This pilot study aimed to (1) compare DNAm patterns between preterm and term infants, (2) examine relationships between NICU-related stress and DNAm alterations in preterm infants, and …

All-Cause And Cause-Specific Mortality In Patients With Bipolar Ii Disorder, Chih-Wei Hsu, Yang-Chieh Brian Chen, Edward Chia-Cheng Lai, Andrew A Nierenberg, Michael Berk, Sheng-Yu Lee, Liang-Jen Wang, Mu-Hong Chen, Yao-Hsu Yang, Chih-Sung Liang, Andre F Carvalho

Children’s Nutrition Research Center Staff Publications

Importance: Whether bipolar II disorder (BD-II) is associated with increased long-term mortality remains uncertain because most studies have not distinguished BD-II from bipolar I disorder (BD-I).

Objective: To examine whether BD-II is associated with elevated all-cause and cause-specific mortality compared with population controls, unaffected siblings, and those with BD-I.

Design, setting, and participants: This population-based, retrospective cohort study used data from Taiwan's National Health Insurance Database from January 1, 2000, to December 31, 2022. Individuals 12 years or older with 2 or more psychiatrist-assigned BD-II diagnoses were individually matched to 4 controls without BD-II by sex and birthdate. Additional comparisons …

N Y State Dent J April 2026

The New York State Dental Journal

In the April 2026 issue, the reader will find the following feature articles:

• Resolution of Severe Lateral Open Bite with Surgically Enhanced Orthodontic and Myofunctional Therapies
• Laser-Assisted New Attachment Procedure: A Review
• Restoration of Dental Implants with Screw-Retained Crowns

This issue includes regular columns with regional news impacting the New York membership including editorial and perspectives columns, legal, association activities, component news, continuing education opportunities, and classifieds.

Identification Of Bioactive Inhibitors In Dragon Fruit (Hylocereus Undatus) Targeting Top2a Protein In Human Breast Cancer, Md Iftehimul, Soharth Hasnat, Md Hasibur Rahman, Md Shohel Hossain, Md Arju Hossain, Abdul Barik, Md Faisal Amin, Dipta Dey, Tofazzal Islam, M. Nazmul Hoque

School of Integrative Biological & Chemical Sciences Faculty Publications

Breast cancer (BC) is the second most common cause of cancer-related mortality worldwide. Topoisomerase II alpha (TOP2A), a key enzyme involved in DNA replication and repair, represents an important biomarker and a promising therapeutic target in BC. This study investigated the therapeutic potential of bioactive compounds from dragon fruit (Hylocereus undatus) as inhibitors of TOP2A using computational biology approaches. A total of 72 phytochemicals were retrieved from the PubChem database and evaluated for binding affinity, toxicity, drug-likeness, and inhibitory potential against TOP2A. Among these, fifteen compounds satisfied Lipinski's rule of five and were predicted to be non-toxic and non-carcinogenic. Further …

Feeding The Mind: Dietary Consumption And Neural Aging, Bhavani Tuppale

Senior Theses

Neural aging is the process of physiological decline in the brain and increased vulnerability to neurodegenerative diseases. Neurodegenerative diseases such as Alzheimer’s disease are associated with aging and the interaction of genetics and lifestyle choices. Previous research studies have connected Alzheimer’s disease with dysfunction in the metabolic system. To combat age-associated dysfunctions in the metabolic system, research studies propose using the ketogenic diet, which utilizes ketone bodies as an energy source instead of glucose. The thesis analyzes literature on the effect of neural aging on various model organisms, how a ketogenic diet affects aging model organisms, and how aging and …

Loss Of Sarm1 Affects Myelin Uptake And Clearance In Macrophages, Grace J. Bergeron

Senior Theses

Clearance of myelin debris is an essential step in nerve regeneration after injury in both the central nervous system (CNS) and peripheral nervous system (PNS), a process that is primarily carried out by macrophages. Failure to phagocytose and clear myelin can prolong inflammation and impair recovery. Sterile alpha and TIR motif-containing protein 1 (SARM1) is well researched as a regulator of axonal degeneration, yet its role in macrophages is still unclear. This study investigates how sarm1 deletion and cytokine signaling influence macrophage uptake and clearance of CNS and PNS myelin in vitro. Splenic macrophages isolated from wild-type (WT) and sarm1 …

The Effects Of Climate Change On Competition And Recovery From Disturbance In An Iconic Marine Community, Lauren Tibbits

Senior Theses

This paper explores how the recovery of populations of Semibalanus balanoides is affected by climate variation. In intertidal marine ecosystems, larval recruitment is important in shaping all ecological processes. S. balanoides is a cold-water barnacle species that is competitively dominant over Chthamalus montagui and C. stellatus, two warm-water species. This competitive interaction is well studied, though it is not understood how that competition influences the recovery of S. balanoides after a disturbance nor how this process varies over a temperature gradient. 19 sites were studied across the United Kingdom, spanning from northern Scotland to southwestern England. At each site, a …