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Efficient Simd Based Implementation Of Xoodyak, Soham Biswas Jul 2025

Efficient Simd Based Implementation Of Xoodyak, Soham Biswas

Master’s Dissertations

Modern computing devices—particularly in the domains of the Internet of Things (IoT), mobile computing, and embedded systems—often operate under severe resource constraints in terms of processing power, memory (RAM/ROM), bandwidth, and battery life. Devices such as IoT sensors, smart cards, medical implants, RFID tags, and wearable systems typically rely on low-power hardware, including 8-bit microcontrollers with only a few kilobytes of memory. Conventional cryptographic algorithms are frequently unsuitable for such environments, as they may consume excessive power, introduce unacceptable latency, or fail to execute altogether. Lightweight cryptography addresses these challenges by providing cryptographic primitives specifically designed to operate efficiently on …


Vitamin K And Women's Health: A Review, Sharifa Alblooshi Jul 2025

Vitamin K And Women's Health: A Review, Sharifa Alblooshi

All Works

Vitamin K is a fat-soluble vitamin essential in various physiological functions such as blood coagulation, bone metabolism, cardiovascular health, glucose regulation, immune function, neuroprotection, and vascular health. In this narrative review, studies from databases including PubMed, Google Scholar, Scopus, and the institutional database of Zayed University were selected. The role of vitamin K in women's health, with a focus on osteoporosis, postmenopausal health, cardiovascular health, diabetes, cancer, kidney health, brain health, vascular health, and pregnancy were explored. The role of vitamin K in activating vitamin K-dependent proteins is essential for many of its functions. Vitamin K-dependent proteins such as osteocalcin …


Integrating Recycled Acrylonitrile–Butadiene–Styrene Plastics From Electronic Waste With Carbon Black For Sustainable Asphalt Production, Sepehr Mohammadi, Dongzhao Jin, Zhanping You Jul 2025

Integrating Recycled Acrylonitrile–Butadiene–Styrene Plastics From Electronic Waste With Carbon Black For Sustainable Asphalt Production, Sepehr Mohammadi, Dongzhao Jin, Zhanping You

Michigan Tech Publications

As the global demand for electronic equipment continues to grow, many devices are being replaced more frequently, resulting in a rapid rise in electronic waste (e-waste), now the fastest growing waste stream worldwide. Motivated by this, the objective of this study is to present an environmentally friendly method to recycle acrylonitrile–butadiene–styrene (ABS), one of the most common e-waste plastics, by using it for asphalt production. In contrast to earlier methods of plastic-modified asphalt production involving complex pretreatments or complimentary additives unsuitable for plant-scale use, this study aims to demonstrate a practical, low-cost solution through the use of carbon black. This …


The Monodromy Leak For A Generalized Montgomery Ladder, Arani Raychaudhuri Jul 2025

The Monodromy Leak For A Generalized Montgomery Ladder, Arani Raychaudhuri

Master’s Dissertations

The Diffie-Hellman key exchange protocol using elliptic curves is the most wide-spread approach to the establishment of a secure internet connection. As an important subroutine, Alice and Bob need to perform multiplications of elliptic curve points by large scalars. The textbook method for scalar multiplication is the double-and-add algorithm. For the sake of efficiency, one usually performs x-coordinate only arithmetic using projective coordinates, and doubling-and-adding is done using the Montgomery ladder. The advantage of using projective coordinates is that this avoids costly field inversions at each iteration. However, when Alice (say) uses the double-and-add algorithm for computing her public key …


Zero Knowledge Proofs In Hybrid Environments, Rittwik Hajra Jul 2025

Zero Knowledge Proofs In Hybrid Environments, Rittwik Hajra

Master’s Dissertations

The impending advent of quantum computing poses a significant threat to classical cryptographic primitives, necessitating a robust migration toward post-quantum cryptographic (PQC) systems. However, a complete transition remains impractical in the short term, giving rise to hybrid environments where classical and PQC schemes coexist. This thesis addresses a fundamental challenge in such settings: the need for efficient and secure zero-knowledge proofs (ZKPs) that establish plaintext consistency across cryptographic primitives defined over distinct algebraic domains. We present novel zero-knowledge protocols that bridge lattice-based schemes, specifically NTRU, with classical constructions like Pedersen vector commitments and ElGamal encryption. Our primary contributions include (1) …


Bondholders Motion To Estimate Tort Claims Jul 2025

Bondholders Motion To Estimate Tort Claims

Catholic Dioceses in Bankruptcy

No abstract provided.


Machine Tool Interoperability In Smart Manufacturing And Industry 4.0, M. R. Mccormick, Mohammed Shafae, Thorsten Wuest Jul 2025

Machine Tool Interoperability In Smart Manufacturing And Industry 4.0, M. R. Mccormick, Mohammed Shafae, Thorsten Wuest

Faculty Publications

Real-time decision making is supported by data-hungry emerging technologies such as machine learning and digital twins. Innovations in manufacturing process control utilizing these technologies are constrained by interoperability. Marketing materials, sales pitches, and academic literature portray interoperability on the factory floor as seamless and robust. However, this study demonstrates that in spite of plentiful mature standards, interoperability on the factory floor is neither seamless nor robust. To exemplify interoperability in the context of an established and widely adopted standard, this study analyzes the interoperability of machine tools produced by a premier equipment builder which has exceeded US$1 billion in sales …


Improving Hiv Nonoccupational Postexposure Prophylaxis Completion In Survivors Of Sexual Assault, Rebecca Aden Jul 2025

Improving Hiv Nonoccupational Postexposure Prophylaxis Completion In Survivors Of Sexual Assault, Rebecca Aden

Doctor of Nursing Practice Final Project Abstract

PURPOSE

This project aimed to increase adherence to HIV nonoccupational postexposure prophylaxis (nPEP) among adult survivors of sexual assault using a 24-hour nurse-led callback intervention to reinforce patient education and support treatment completion.

BACKGROUND

This project was implemented within a public healthcare system’s forensic nursing program. Sexual assault survivors face an elevated risk of HIV transmission, yet completion of the 28-day nPEP regimen often remains below 40%. Barriers to completion include limited understanding, gaps in follow-up, as well as psychosocial and socioeconomic challenges.

METHODOLOGY

The FADE QI framework was utilized for this project. The population included adult, non-incarcerated patients who …


Atom-Chip Compatible Optical Lattice, Robert Leonard, Spencer E. Olson Jul 2025

Atom-Chip Compatible Optical Lattice, Robert Leonard, Spencer E. Olson

Space Dynamics Laboratory Publications

A lattice beam configuration which results in an isotropic 3D trap near the surface of an atom chip is described. The lattice is formed near the surface of a reflectively coated atom chip, where three incident beams and three reflected beams intersect. The coherent interference of these six beams form a phase-stable optical lattice which extends to the surface of the atom chip. The lattice is experimentally realized and the trap frequency is measured. Degenerate Raman sideband cooling is performed in the optical lattice, cooling 80 million atoms to 1.1 μK.


State Of Utah, Plaintiff/ Appellee V. Daniel Macbeth, Defendant/ Appellant : Reply Brief, Utah Court Of Appeals Jul 2025

State Of Utah, Plaintiff/ Appellee V. Daniel Macbeth, Defendant/ Appellant : Reply Brief, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

On appeal from the Fourth Judicial District Court, Utah County, Honorable Robert C. Lunnen, District Court No. 211402124

REBECCA BARKER, DEREK E. BROWN, Counsel for Appellee

Freyja Johnson, Rachel Phillips Ainscough, Counsel for Appellant


Mir-302a/B/D-3p Differentially Expressed During Frontonasal Development Is Sensitive To Retinoic Acid Exposure, Chihiro Iwaya, Akiko Suzuki, Goo Jun, Junichi Iwata Jul 2025

Mir-302a/B/D-3p Differentially Expressed During Frontonasal Development Is Sensitive To Retinoic Acid Exposure, Chihiro Iwaya, Akiko Suzuki, Goo Jun, Junichi Iwata

Faculty, Staff and Student Publications

Any failure in frontonasal development can lead to malformations at the middle facial region, such as frontonasal dysplasia, midfacial clefts, and hyper/hypotelorism. Various environmental factors influence morphogenesis through epigenetic regulations, including the action of noncoding microRNAs (miRNAs). However, it remains unclear how miRNAs are involved in the frontonasal development. In our analysis of publicly available miRNA-seq and RNA-seq datasets, we found that miR-28a-5p, miR-302a-3p, miR-302b-3p, and miR-302d-3p were differentially expressed in the frontonasal process during embryonic days 10.5 to 13.5 (E10.5–E13.5) in mice. Overexpression of these miRNAs led to a suppression of cell proliferation in cultured mouse embryonic frontonasal mesenchymal …


Molecular Epidemiology And Clinical Characterization Of Carbapenemase-Producing Enterobacter Species From An International Cohort, Jianping Jiang, Lauren Komarow, Carol Hill, Angelique E Boutzoukas, Blake Hanson, Cesar A Arias, Robert A Bonomo, Scott Evans, Yohei Doi, Michael J Satlin, Gregory Weston, Eric Cober, Sandra Liliana Valderrama-Beltran, Soraya Salcedo Mendoza, Zhengyin Liu, Bettina C Fries, Paul Ananth Tambyah, Henry F Chambers, Vance G Fowler, David Van Duin, Barry N Kreiswirth, Liang Chen Jul 2025

Molecular Epidemiology And Clinical Characterization Of Carbapenemase-Producing Enterobacter Species From An International Cohort, Jianping Jiang, Lauren Komarow, Carol Hill, Angelique E Boutzoukas, Blake Hanson, Cesar A Arias, Robert A Bonomo, Scott Evans, Yohei Doi, Michael J Satlin, Gregory Weston, Eric Cober, Sandra Liliana Valderrama-Beltran, Soraya Salcedo Mendoza, Zhengyin Liu, Bettina C Fries, Paul Ananth Tambyah, Henry F Chambers, Vance G Fowler, David Van Duin, Barry N Kreiswirth, Liang Chen

Faculty, Staff and Student Publications

Background: Despite the global public health threat posed by carbapenem-resistant Enterobacter spp, clinical and molecular epidemiological studies on international isolates remain scarce. Historically, the taxonomy of Enterobacter has been challenging, limiting our understanding of the clinical characteristics and outcomes of carbapenemase-producing Enterobacter spp infections.

Methods: Hospitalized patients enrolled in the CRACKLE-2 study (ClinicalTrials.gov, NCT03646227) from 2016 to 2018 with cultures positive for carbapenemase-producing Enterobacter spp were included. Clinical and microbiologic data were collected from health records. Whole genome sequencing was performed, and the population structures of selected predominant clones were analyzed.

Results: We enrolled 136 hospitalized patients with carbapenemase-producing …


The U.S. Executive Order On Seabed Mining Is Consistent With International Law, James Kraska Jul 2025

The U.S. Executive Order On Seabed Mining Is Consistent With International Law, James Kraska

International Law Studies

This article analyzes the legality of U.S. unilateral seabed mining authorized by Executive Order 14285, signed by President Donald Trump on April 24, 2025, permitting mineral extraction on the U.S. continental shelf and international deep seabed. Critics, including China, the European Union, and the International Seabed Authority, contend that this policy violates international law by circumventing Part XI of the United Nations Convention on the Law of the Sea (UNCLOS), which designates seabed minerals as the “common heritage of mankind” and mandates regulation through the ISA. The article asserts that, as a non-party to UNCLOS, the United States is not …


Reducing Use Of Force In Law Enforcement Through Higher Education, Joseph J. Davern Jul 2025

Reducing Use Of Force In Law Enforcement Through Higher Education, Joseph J. Davern

Walden Dissertations and Doctoral Studies

This quantitative research study examined whether earning a college degree reduced police officers’ use of force in Massachusetts during 2023. Reducing force incidents is a concern for both citizens and law enforcement due to increasing public scrutiny and a need to improve community-police relations. The purpose of this study was to determine whether police officers with college degrees are less likely to use force during citizen encounters compared to those with only a high school diploma. The first research question explored the difference in the amount of force used by municipal police officers with college degrees versus those with high …


Restoring Sacred Priorities: Laying Down The Idol Of Family, Leah Mouw Jul 2025

Restoring Sacred Priorities: Laying Down The Idol Of Family, Leah Mouw

Faculty Work Comprehensive List

"While marriage and family are good gifts, they are not the goal of the Christian life."

Posting about ­­­­­­­­prioritizing our relationship with God from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Restoring Sacred Priorities


Investigation Of The Interaction Between Diethyl Phthalate And Ovalbumin Via Spectroscopic Techniques And Molecular Docking, Fu Chen, Huang Qun Jul 2025

Investigation Of The Interaction Between Diethyl Phthalate And Ovalbumin Via Spectroscopic Techniques And Molecular Docking, Fu Chen, Huang Qun

Food and Machinery

[Objective] To explore the interaction mechanism between diethyl phthalate (DEP ) and ovalbumin (OVA ) using multispectral analysis and molecular docking techniques.[Methods] The Stern -Volmer equation is applied to study the fluorescence quenching mechanism of OVA by DEP,as well as to determine the binding constants and the number of binding sites between them.Thermodynamic parameters are used to identify the primary types of interaction forces.Based on Förster's non -radiative energy transfer theory,the energy transfer efficiency and binding distance between DEP and OVA are calculated.Molecular docking simulations are used to investigate the interaction forces between DEP and OVA.[Results]] DEP can statically quench …


Advances In The Application Of Machine Learning To Food Nutrition And Health, Zhou Xin, Li Dapeng Jul 2025

Advances In The Application Of Machine Learning To Food Nutrition And Health, Zhou Xin, Li Dapeng

Food and Machinery

A balanced diet is fundamental to maintaining human health and preventing or reducing the risk of chronic non -communicable diseases.Efficient and accurate analysis of nutritional and functional components in food,followed by the provision of personalized nutritional guidance,is a research hotspot in the field of food nutrition and health.This article reviews the research progress on artificial intelligence technologies,such as machine learning,in the analysis of food nutritional components,functional component analysis and screening,and personalized nutrition,and highlights the pressing issues that need to be addressed in this field.


Conformational Ligand-Directed Targeting Of Calcium-Dependent Receptors In Acute Trauma, Renata Pasqualini, Christopher Markosian, Daniela I Staquicini, Andrey S Dobroff, Esteban Dodero-Rojas, Paul C Whitford, E Magda Barbu, Julianna K Bronk, Marina Cardó-Vila, Dawn R Christianson, Emmanuel Dias-Neto, Wouter H P Driessen, Liliana Guzman-Rojas, Serena Marchiò, Diana N Nunes, Francislon S De Oliveira, Michael G Ozawa, Bettina Proneth, Roberto Rangel, Tracey L Smith, Glauco R Souza, Fernanda I Staquicini, Fenny H F Tang, Wallace B Baze, João C Setubal, John W Burns, Michael A Dubick, Juri G Gelovani, Andriy I Batchinsky, Jon E Mogford, Charles E Wade, John B Holcomb, Stephen K Burley, José N Onuchic, Wadih Arap Jul 2025

Conformational Ligand-Directed Targeting Of Calcium-Dependent Receptors In Acute Trauma, Renata Pasqualini, Christopher Markosian, Daniela I Staquicini, Andrey S Dobroff, Esteban Dodero-Rojas, Paul C Whitford, E Magda Barbu, Julianna K Bronk, Marina Cardó-Vila, Dawn R Christianson, Emmanuel Dias-Neto, Wouter H P Driessen, Liliana Guzman-Rojas, Serena Marchiò, Diana N Nunes, Francislon S De Oliveira, Michael G Ozawa, Bettina Proneth, Roberto Rangel, Tracey L Smith, Glauco R Souza, Fernanda I Staquicini, Fenny H F Tang, Wallace B Baze, João C Setubal, John W Burns, Michael A Dubick, Juri G Gelovani, Andriy I Batchinsky, Jon E Mogford, Charles E Wade, John B Holcomb, Stephen K Burley, José N Onuchic, Wadih Arap

Faculty, Staff and Student Publications

Background: Trauma is a leading cause of mortality, but injury-specific molecular targets remain largely unknown. We hypothesized that distinctive yet unrecognized tissue targets accessible to circulating ligands might emerge during trauma, thereby underscoring a trauma-related proteome.

Methods: We screened a peptide library to discover targets in a porcine model of major trauma: compound femur fracture with hemorrhagic shock. Bioinformatics yielded conserved motifs, and candidate receptors were affinity purified. In silico and in vitro approaches served to investigate possible associations between candidate receptors and calcium, a major component of skeletal muscle and bone. In vivo homing and molecular imaging (PET/MRI and …


Detecting Misuse Of Security Apis: A Systematic Review, Zahra Mousavi, Chadni Islam, Muhammad Ali Babar, Alsharif Abuadbba, Kristen Moore Jul 2025

Detecting Misuse Of Security Apis: A Systematic Review, Zahra Mousavi, Chadni Islam, Muhammad Ali Babar, Alsharif Abuadbba, Kristen Moore

Research outputs 2022 to 2026

Security Application Programming Interfaces (APIs) are crucial for ensuring software security. However, their misuse introduces vulnerabilities, potentially leading to severe data breaches and substantial financial loss. Complex API design, inadequate documentation, and insufficient security training often lead to unintentional misuse by developers. The software security community has devised and evaluated several approaches to detecting security API misuse to help developers and organizations. This study rigorously reviews the literature on detecting misuse of security APIs to gain a comprehensive understanding of this critical domain. Our goal is to identify and analyze security API misuses, the detection approaches developed, and the evaluation …


Combination Hyaluronic Acid And Multipotent Stromal Cells Fails To Improve Rat Knee Oa Outcomes Compared To Cells Alone, Kennedy Michele Davis, Megan Hamilton, Donald Muathe, Aldyn Wildey, Stephen Harrington, Douglas Bittel, Michael Filla, Lisa Stehno-Bittel Jul 2025

Combination Hyaluronic Acid And Multipotent Stromal Cells Fails To Improve Rat Knee Oa Outcomes Compared To Cells Alone, Kennedy Michele Davis, Megan Hamilton, Donald Muathe, Aldyn Wildey, Stephen Harrington, Douglas Bittel, Michael Filla, Lisa Stehno-Bittel

Faculty and Staff Publications

Introduction: Multipotent Stromal Cells (MSCs) are utilized as therapeutic agents for addressing musculoskeletal conditions, including knee osteoarthritis (OA). However, major challenges in the clinical application include maintenance of the cells in the joint capsule. Hyaluronic acid (HA) is endogenous in synovial joints and commercially available as a joint lubricant. We tested the hypothesis that delivery of MSCs in HA into an OA rat knee model could improve outcomes.

Methods: Rat bone marrow MSCs were suspended in a commercially available HA paste, and cell viability measured with live/dead stains. Biomarkers for MSC chondrogenesis and osteogenesis were monitored with PCR. MSCs with …


Antibiotic Use In Rural Kenyan Livestock: Navigating Misuse, Experience Gaps And Amr Risks, Lucy Obolensky, Esbon Wambugu, Edna Kubai, Iain Doig, Miriam Beattie, Michael Dillon Jul 2025

Antibiotic Use In Rural Kenyan Livestock: Navigating Misuse, Experience Gaps And Amr Risks, Lucy Obolensky, Esbon Wambugu, Edna Kubai, Iain Doig, Miriam Beattie, Michael Dillon

Peninsula Medical School

Antimicrobial resistance (AMR) is an escalating global health threat, with the greatest risk observed in low- to middle-income countries, particularly in the global south. The World Health Organization advocates for a One Health approach to address AMR, promoting collaboration across sectors, including in agriculture. This study aims to enhance understanding of antimicrobial use and stewardship in livestock within pastoralist communities in northern Kenya, where there is limited information. The study employed a qualitative approach, using semi-structured interviews to gather data on farming practices and antibiotic use. Interviews were conducted by trained volunteers proficient in Swahili and Ma (a Maasai language), …


Bsc Owner Llc V. Holley Jul 2025

Bsc Owner Llc V. Holley

All Decisions

The court granted the tenant's motion to dismiss a nonpayment case because the landlord could not produce a valid lease for the period in which the alleged arrears accrued. The landlord's argument that a "HUD Model Lease" provided for a perpetual lease was rejected by the court, which found that the rental amount changing from year to year made the lease indefinite on a material term. Consequently, with no lease in effect for the relevant time, the landlord could not maintain the nonpayment proceeding.


Prospects For Telemedicine Adoption: Prognostic Modeling As Exemplified By Rural Areas Of Usa, Jisun Kim, Hamad Alanazi, Tugrul Daim Jul 2025

Prospects For Telemedicine Adoption: Prognostic Modeling As Exemplified By Rural Areas Of Usa, Jisun Kim, Hamad Alanazi, Tugrul Daim

Engineering and Technology Management Faculty Publications and Presentations

Experts predict that in the majority of countries state healthcare expenditures will continue to rise. Usage of telemedicine applications – the use of information and communications technologies (ICT) in order to provide clinical health care at a distance – will help optimize the costs of healthcare in the long-term. The main advantages of telemedicine include reducing the number of doctor’s errors, saving both patients and physicians time, and improving the efficiency of healthcare organizations. It also ensures timely and quality services for large segments of the population living in remote territories with difficult socio-economic conditions, particularly rural areas.The paper forecasts …


Impact Of Sanitation System Types On Residential And Environmental Presence Of Human Waste And Parasites In Alabama, Brandon Hunter, Catherine Coleman Flowers, Rojelio Mejia, Marc Arnold Deshusses Jul 2025

Impact Of Sanitation System Types On Residential And Environmental Presence Of Human Waste And Parasites In Alabama, Brandon Hunter, Catherine Coleman Flowers, Rojelio Mejia, Marc Arnold Deshusses

Faculty, Staff and Students Publications

Lowndes County is a predominantly Black rural county in Alabama, in the United States, which has a historical and current legacy of racial discrimination, creating inequitable infrastructure access and adverse health impacts. Over 80% rely on on-site sanitation infrastructure and most are failing. A community assessment of exposure to untreated sewage was conducted using samples from residential drinking water, surface swabs, and soil combined with environmental water and soil samples using culture-based and quantitative polymerase chain reaction (qPCR) methods. Testing varied slightly across samples, due to difficulty of access or availability. Of 43 households, 68% and 55% of houses had …


Rapid High-Sensitivity Detection Of Antibodies To Trypanosoma Cruzi With A Recombinant Tc24 Antigen-Based Magneto-Immunoassay: A Pilot Study, Kavya L Singampalli, Bin Zhan, Rojelio Mejia, Peter B Lillehoj Jul 2025

Rapid High-Sensitivity Detection Of Antibodies To Trypanosoma Cruzi With A Recombinant Tc24 Antigen-Based Magneto-Immunoassay: A Pilot Study, Kavya L Singampalli, Bin Zhan, Rojelio Mejia, Peter B Lillehoj

Faculty, Staff and Students Publications

The diagnosis of chronic Chagas disease is challenging due to the wide genetic diversity of Trypanosoma cruzi, the causative agent of Chagas disease, and low levels of parasitemia, resulting in low sensitivity and accuracy with existing diagnostics. We report a magneto-immunoassay that employs dually labeled magnetic beads incorporating a recombinant Tc24 antigen, which is homologous across multiple discrete typing units of T cruzi. In this pilot study, 102 serum samples from 7 endemic countries were tested by this magneto-immunoassay, revealing its ability to distinguish Chagas-positive from Chagas-negative cases more accurately and faster than a standard Tc24-based immunoassay.


Occurrence Of Pesticides In Oregon Coastal Waters And Effects On The Intertidal Sea Anemone, Anthopleura Elegantissima, Gabriella Mae Bleil Jul 2025

Occurrence Of Pesticides In Oregon Coastal Waters And Effects On The Intertidal Sea Anemone, Anthopleura Elegantissima, Gabriella Mae Bleil

Dissertations and Theses

Pesticides are used globally for a wide range of applications including agricultural, forestry, roadsides, freshwater systems, and personal use. While pesticides have ensured efficient crop production, they are frequently transported away from application sites and are ubiquitous in terrestrial and aquatic environments. Pesticides are often detected in watersheds and rivers globally, which can have unintentional toxic effects on non-target organisms by interfering with cellular processes, behavior, feeding, reproduction, and disrupting endocrine processes. The aggregating anemone, Anthopleura elegantissima, is an important species along the North American Pacific coast due to its symbiotic relationships that contribute to high productivity, and its …


Analyses Of Morphological Effects Of Cryopreservation On Plasmodium Yoelii Sporozoites, Lauren J. Topley Jul 2025

Analyses Of Morphological Effects Of Cryopreservation On Plasmodium Yoelii Sporozoites, Lauren J. Topley

USF Tampa Graduate Theses and Dissertations

Malaria is a vector-borne disease and is a major global public health threat caused by the genus Plasmodium. Of the five species that infected humans, Plasmodium vivax and Plasmodium falciparum contribute the highest rates of morbidity and mortality. Research efforts to develop antimalarial drugs and effective vaccines is imperative to the prevention of future cases. Plasmodium has three reproductive stages: sporogonic, liver, and blood. Sporozoites are injected into the human host from an infected female Anopheles mosquito, which travel to the liver to initiate liver stage malaria. Since few sporozoites are successful, the liver stage is a bottleneck of the …


Oral Dosing Of The Nucleoside Analog Obeldesivir Is Efficacious Against Rsv Infection In African Green Monkeys, Jared Pitts, J Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Vincent Cutillas, Varsha Nair, Nicholas C Riola, Arya Vijjapurapu, Meghan S Vermillion, Stacey Eng, Christopher Richards, Dong Han, Jason K Perry, Subhra Chaudhuri, Szu-Wen Liu, Clarissa Martinez, Nadine Peinovich, Kai-Hui Sun, Arthur Cai, Ross Martin, Jasmine Moshiri, Charlotte Hedskog, Darius Babusis, Dustin S Siegel, Rao Kalla, Vasanthi Avadhanula, Pedro A Piedra, Kim Stobbelaar, Peter L Delputte, Caleb Marceau, Roberto Mateo, Evguenia Maiorova, Hongmei Mo, Raju Subramanian, Richard L Mackman, Tomas Cihlar, Simon P Fletcher, John P Bilello Jul 2025

Oral Dosing Of The Nucleoside Analog Obeldesivir Is Efficacious Against Rsv Infection In African Green Monkeys, Jared Pitts, J Lizbeth Reyes Zamora, Savrina Manhas, Thomas Aeschbacher, Josolyn Chan, Vincent Cutillas, Varsha Nair, Nicholas C Riola, Arya Vijjapurapu, Meghan S Vermillion, Stacey Eng, Christopher Richards, Dong Han, Jason K Perry, Subhra Chaudhuri, Szu-Wen Liu, Clarissa Martinez, Nadine Peinovich, Kai-Hui Sun, Arthur Cai, Ross Martin, Jasmine Moshiri, Charlotte Hedskog, Darius Babusis, Dustin S Siegel, Rao Kalla, Vasanthi Avadhanula, Pedro A Piedra, Kim Stobbelaar, Peter L Delputte, Caleb Marceau, Roberto Mateo, Evguenia Maiorova, Hongmei Mo, Raju Subramanian, Richard L Mackman, Tomas Cihlar, Simon P Fletcher, John P Bilello

Faculty, Staff and Students Publications

Respiratory syncytial virus (RSV) is a significant cause of morbidity and mortality in high-risk populations. Although prophylactic options are available, there are no effective oral therapeutics for RSV infection. Obeldesivir (ODV) is an orally bioavailable prodrug of the nucleoside analog GS-441524, which is converted intracellularly to its active nucleoside triphosphate and inhibits the RSV RNA polymerase. Here we report the potent antiviral activity of ODV against geographically and temporally diverse RSV A and B clinical isolates (EC50: 0.20–0.66 μM). Resistance selection studies with ODV and GS-441524 against RSV identify a single amino acid substitution, I777L, in the L polymerase with …


Effects Of Seasonality On The Experiences Of Employees In Minor League Sports, Amanda Barefoot Jul 2025

Effects Of Seasonality On The Experiences Of Employees In Minor League Sports, Amanda Barefoot

LSU Doctoral Dissertations

The temporal rhythms of sport organizations, driven by recurring cycles of in-season and off-season activity, create a unique organizational context that shapes decision-making, leadership behavior, and the experiences of employees. While seasonality is widely recognized in operational planning and revenue forecasting, its implications for organizational behavior in sport management remain underexplored. This three-paper dissertation examines seasonality as a temporal force influencing sport organizations at conceptual, strategic, and affective levels.

The first paper develops a sport-specific taxonomy of seasonality by synthesizing literature from econometrics, tourism, and organizational theory. It distinguishes between natural, internally institutionalized, and externally institutionalized seasonal influences, offering a …


The Current And Future Burden Of Long Covid In The United States, Sarah M Bartsch, Kevin L Chin, Ulrich Strych, Danielle C John, Tej D Shah, Maria Elena Bottazzi, Kelly J O'Shea, Mckaylee Robertson, Colleen Weatherwax, Jessie Heneghan, Marie F Martinez, Allan Ciciriello, Sarah Kulkarni, Kavya Velmurugan, Alexis Dibbs, Sheryl A Scannell, Yanhan Shen, Denis Nash, Peter J Hotez, Bruce Y Lee Jul 2025

The Current And Future Burden Of Long Covid In The United States, Sarah M Bartsch, Kevin L Chin, Ulrich Strych, Danielle C John, Tej D Shah, Maria Elena Bottazzi, Kelly J O'Shea, Mckaylee Robertson, Colleen Weatherwax, Jessie Heneghan, Marie F Martinez, Allan Ciciriello, Sarah Kulkarni, Kavya Velmurugan, Alexis Dibbs, Sheryl A Scannell, Yanhan Shen, Denis Nash, Peter J Hotez, Bruce Y Lee

Faculty, Staff and Students Publications

Background: Long coronavirus disease (COVID), which affects an estimated 44.69-48.04 million people in the United States, is an ongoing public health concern that will persist as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread.

Methods: We developed a computational simulation model representing the clinical course, health effects, and associated costs of a person with long COVID.

Results: Simulations show that the average total cost of a long COVID case can range from $5084-$11 646 (assuming symptoms only last 1 year) with 92.5%-95.2% of these costs being productivity losses. Therefore, the current number of long COVID cases could cost …