Digital Commons Network^™

Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions In Oropharyngeal Cancers, Nusrat Khan, Keiko Akagi, Shiming Jiang, Joe Dan Dunn, Bo Jiang, Weihong Xiao, Madison P O'Hara, Li Shen, Qi Wang, Vakul Mohanty, Jing Wang, Sara Goodwin, Jamie L Hutchins, Kevin R Coombes, Jagannadha K Sastry, David E Symer, Maura L Gillison

Faculty, Staff and Student Publications

HPV integration disrupts host genomic structure and expression, but whether these alterations promote cancer development remains unclear. Multiple genomic analyses of oropharyngeal cancers identified several host fusion genes, including recurrent FGFR3-TACC3 fusions, expressed from rearranged genomic loci adjacent to HPV integration sites. Evolutionary modeling implicated integration of virus concatemers into the host genome as a common initiating event in fusion formation. Co-expression of HPV16 E6/E7 and FGFR3-TACC3, but neither alone, was sufficient for tumor development in both xenograft and syngeneic mouse models and led to unique transcriptional programs implicated in carcinogenesis. FGFR3-TACC3 expression decreased the ubiquitination and degradation of …

Quaker Campus, September 4, 2025 (Vol. 24, Issue 1), Whittier College

Quaker Campus

No abstract provided.

Improving Efficiency Of Prime Editing For Superior Genetic Traits In Livestock, Iuri Viótti Périssé

Funded Research Records

No abstract provided.

September 4, 2025, The Daily Mississippian

Daily Mississippian (all digitized issues)

No abstract provided.

September 4, 2025, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Perspectives On Mathematical Modeling Education: Conceptions And Research, Geena Taite, Joseph Dinapoli

Department of Mathematics Faculty Scholarship and Creative Works

Mathematical modeling is a cyclical process in which mathematics is used to represent, explore, and better understand real-world situations by mathematizing a problem and validating the results. Unlike traditional word problems, modeling tasks require learners to make assumptions, define quantities, apply mathematics, interpret results, and revise solutions within authentic contexts. Mathematical modeling is increasingly recognized as essential in mathematics education, highlighted in standards such as the Common Core State Standards for Mathematics through mathematical practice 4 (MP4): model with mathematics. This entry explores the evolving landscape of mathematical modeling education. First, it reviews the diverse conceptions of modeling and the …

Detection Of Cancers Three Years Prior To Diagnosis Using Plasma Cell-Free Dna, Yuxuan Wang, Corinne E Joshu, Samuel D Curtis, Christopher Douville, Vernon A Burk, Meng Ru, Maria Popoli, Janine Ptak, Lisa Dobbyn, Natalie Silliman, Josef Coresh, Eric Boerwinkle, Anna Prizment, Chetan Bettegowda, Kenneth W Kinzler, Nickolas Papadopoulos, Elizabeth A Platz, Bert Vogelstein

Faculty, Staff and Student Publications

To explore how early can cancers be detected prior to clinical signs or symptoms, we assessed prospectively collected serial plasma samples from the Atherosclerosis Risk in Communities (ARIC) study, including 26 participants diagnosed with cancer and 26 matched controls. At the index time point, eight of these 52 participants scored positively with a multicancer early detection (MCED) test. All eight participants were diagnosed with cancer within 4 months after blood collection. In six of these 8 participants, we were able to assess an earlier plasma sample collected 3.1 to 3.5 years prior to clinical diagnosis. In four of these six …

Human Adipose Stem Cell-Derived Small Extracellular Vesicles Modulate Glial Cell Response In Aged And Young Tbi Mouse Models, Salma S. Abdelmaboud

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) is a leading cause of long-term neurological impairment, with aging significantly increasing vulnerability and worsening outcomes. Older individuals experience greater cognitive and motor deficits after TBI and often show diminished responses to therapeutic interventions. Both aging and TBI independently promote heightened neuroinflammation and cognitive dysfunction, increasing susceptibility to poor recovery. This study investigated the therapeutic potential of small extracellular vesicles (sEVs) derived from human adipose-derived stem cells (hASCs) to promote neurological recovery and modulate neuroinflammation in a mouse model of TBI. Male C57BL/6 mice aged 3, 15, and 20 months underwent controlled cortical impact (CCI) and …

A Proven Template For Providing Streamlined, Scalable, Cost-Effective Clinical Research Opportunities In Osteopathic Medical Schools, Jacey N. Greek, Andrew Greek, Mari Hopper, Robert Arnce

Student Publications

Context: In an era in which clinical research plays a crucial role in advancing medical knowledge and contributing to the resume of medical students attempting to match into a residency, the creation of sustainable and effective research opportunities within medical education is paramount. Colleges of Osteopathic Medicine (COMs) face unique challenges in creating these opportunities in a scalable and cost-efficient manner. Without these opportunities, osteopathic medical students may find themselves at a disadvantage compared to their allopathic counterparts in residency placements and academic career paths.

Objectives: We have created a template for providing perpetual, streamlined, scalable, cost-effective clinical research at …

Cmsi Note 16: Confirmed: Adm Yuan Huazhi Removed As The Plan’S Political Commissar, Andrew S. Erickson

CMSI Notes

Key Takeaways:

• An authoritative source has confirmed what many had long suspected: Admiral Yuan Huazhi is no longer serving as the Political Commissar of the People’s Liberation Army Navy (PLAN). As the chief political officer, the Political Commissar shares responsibility with the PLAN Commander for leading the service.

• While the details of ADM Yuan’s departure are unknown, it is very likely that he was a victim of the massive purge within China’s military that began in mid-2023. Unlike other senior PLA officers implicated in the purge, however, ADM Yuan’s status has not been publicly disclosed.

• ADM Yuan …

2025-09-04 Faculty Senate Scoop Newsletter, Morehead State University. Faculty Senate.

Faculty Senate Records

Faculty Senate Scoop newsletter from September 4, 2025.

The Causal Pivot: A Structural Approach To Genetic Heterogeneity And Variant Discovery In Complex Diseases, Chad A Shaw, C J Williams, Taotao Tan, Daniel Illera, Nicholas Di, Joshua M Shulman, John W Belmont

Center on Aging Staff Publications

We present the Causal Pivot (CP) as a structural causal model (SCM) for analyzing genetic heterogeneity in complex diseases. The CP leverages an established causal factor or factors to detect the contribution of additional suspected causes. Specifically, polygenic risk scores (PRSs) serve as known causes, while rare variants (RVs) or RV ensembles are evaluated as candidate causes. The CP incorporates outcome-induced association by conditioning on disease status. We derive a conditional maximum-likelihood procedure for binary and quantitative traits and develop the Causal Pivot likelihood ratio test (CP-LRT) to detect causal signals. Through simulations, we demonstrate the CP-LRT’s robust power and …

Influences On Suicidality And Suicide-Prevention Needs For The Autistic Community: Qualitative Insights From Multiple Perspectives, Anne V. Kirby, Kristina Feldman, Wilhelm Clark, Amber N. Darlington, Alissa Atisme, Bobbi Duncan-Ishcomer, Rachel Kripke-Ludwig, Andrea Joyce, Whitney Lee, K. Rodriguez, Zack Siddeek, Kavitha Murthi, Brooks Keeshan, Hilary Coon, Christina Nicolaidis

School of Social Work Faculty Publications and Presentations

Autistic individuals are disproportionately likely to experience suicidal thoughts, feelings, and actions. Addressing suicidality is also a high priority of autistic community members. The goal of this study was to understand broad influences on suicidality and suicide-prevention needs for the autistic community. Using a community-based participatory research approach, we conducted a reflective thematic analysis of qualitative interviews with 16 autistic adults, 8 family members, and 14 mental health providers. Themes summarizing influences on suicidality and suicide-prevention needs centered on three broad thematic concepts: (1) Pervasive negative societal attitudes and social experiences have a lasting impact on autistic people's feelings of …

Climate Change-Related Threats To Railroads: Implications For Threat, Hazard And Risk Assessment, Frances L. Edwards, Daniel C. Goodrich

Faculty Research, Scholarly, and Creative Activity

Climate change has created new challenges for railroads around the world. The rail systems operate in open environments, subjecting them to increased heat, changing locations of heavy rains, developing sea level rise and storm surge, and a longer and stronger wildfire season. This research investigates how an updated threat and hazard identification and risk assessment (THIRA) can lead to the development of climate adaptation strategies that limit damage and disruption to the railroad enterprise. The THIRA analyzes which threats are of most concern in a specific rail segment, and which climate change adaptation strategies give a beneficial return on investment.

Preconditioning With Low-Dose Radiation Improves Antitumor Immunity And Survival In Dc-Vaccinated Mice, Eric Kwon, Shelby Namen, Colin J Willoughby, Solomon Kang, Gaurav Pandey, Alexander B Kim, Carl J Deselm

2020-Current year OA Pubs

Preconditioning regimens are essential for the immunologic success of cell therapies like CAR T cells. Nevertheless, their effect on cancer vaccines is underexplored, and preconditioning regimens are generally absent from cancer vaccine clinical trials. To address this knowledge gap, we evaluated the impact of various preconditioning strategies on dendritic cell (DC) vaccine efficacy in a murine tumor model. Mice bearing syngeneic tumors received preconditioning with 2 Gy low-dose radiation therapy (LD RT; whole-body or tumor-only), cyclophosphamide, paclitaxel, LD RT plus cyclophosphamide, or no preconditioning, followed by administration of antigen-loaded DCs. Whether whole-body or tumor-directed, LD RT preconditioning significantly enhanced vaccine-induced …

Risk Of Clonal Hematopoiesis In Families Exposed To Radiation Following The Chornobyl Accident, Mitchell J Machiela, Irenaeus Chan, Kelly Bolton, Et Al.

2020-Current year OA Pubs

Radiation exposure is a well-established risk factor for leukemia. Clonal hematopoiesis (CH), the expansion of mutated hematopoietic cells, is also associated with increased leukemia risk and its frequency is higher in cancer patients following radiotherapy and chemotherapy. We investigated whether low to moderate environmental ionizing radiation determined by state-of-the-art dosimetric analysis was associated with CH in the Chornobyl Family Study (CFS). Our study conducted targeted high-depth sequencing and array genotyping to identify and characterize clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) in 882 participants from 292 CFS families. Fathers had mean bone marrow radiation doses of …

Dampak Jumlah Kredit Yang Dimiliki Rumah Tangga Terhadap Kekerasan Dalam Rumah Tangga (Kdrt) Pada Anak Di Indonesia, Anjar Maulitfiani, Dwini Handayani

Jurnal Kebijakan Ekonomi

This study examines the impact of intensity of household debt on domestic violence (DV) towards children in Indonesia. There is a positive relationship between the amount of household debt and the likelihood of domestic violence towards children based on literature review. This research uses a quantitative method with multinomial logistic regression analysis. The results of this study indicate that households with more than one household debt are correlated with an increased likelihood of both psychological and physical domestic violence towards children compared to the likelihood of no domestic violence, both before and after controlling variables added.

A Tale Of Two Schools: A Comparative Case Study Demonstrating Organizational Pathways To Educator Collaborations, Michael W. Valenti Ph.D., Duhita Mahatmya, Elizabeth Levine-Brown, Karen Celedonia, Tracy Sweet

Mid-Western Educational Researcher

Effective staff collaboration in schools maximizes educators’ collective capacity, improves educator and student outcomes, and facilitates school-wide improvement efforts. Yet, many school team members struggle to collaborate effectively. Previous studies have demonstrated individual and school-level factors that influence school-based collaborations. This study expands former research by comparing the varying administrative and environmental tools employed by two schools to shape relational networks and foster interpersonal capital. Specifically, this case study explores how school-level factors shape the development of school social networks and staff collaborative behavior. We use comparative case study analysis to explore how differences in individual-level and system-level factors influence …

Exploring Health Care Access Among Lesbian, Gay, Bisexual, And Transgender (Lgbt) Populations, Austin Nation, Phyllis Raynor, Frieda H. Outlaw, Carlo Hojilla

International Nursing Research Congress (INRC)

PURPOSE: The purpose of this project is to explore the current experiences and needs of the lesbian, gay, bisexual, and transgender (LGBT) population, including health care and mental health utilization, patterns, locations, adequacy of LGBT-friendly health and mental health care providers. There are an estimated 90,000 LGBT individuals over the age of 14 in Orange County. LGBT populations are unique and are known to have significant health disparities, particularly if they are from racial or ethnic groups or have a disability. LGBT individuals are known to experience adverse situations when accessing health care and mental health services, including issues with …

Authentic Leadership In Nursing: Global Impact And Insights From An Integrative Review, Robie Victoria Hughes, Jihane Frangieh, Julia Cardoso Cardoso

International Nursing Research Congress (INRC)

The purpose of the integrative review is to analyze the current literature to determine authentic leadership impact on nursing outcomes world-wide. Authentic leadership theory, studied extensively in recent years, is a critical component of effective leadership in healthcare linked to improved patient outcomes, increased healthy work environments, and decreased burnout rates among nurses. An integrative literature search on “authentic leadership”, “outcomes” and “nursing” was conducted in five electronic databases: CINAHL, EMBASE, Web of Science, Scopus, and MEDLINE via the PubMed portal, from February 2023 to April 2023. Twenty-five quantitative studies, conducted in 10 countries, met the inclusion criteria. The authors …

Faculty Facilitated New Graduate Nurse Mentoring Program, Tina Michelle Dorau

International Nursing Research Congress (INRC)

Background: There has been a lack of consistent high-quality residency and orientation programs for new graduate registered nurses (NGRNs) throughout the United States including Central Wisconsin.

Purpose: The practice gap has existed for many years and was recognized in the 1970’s when Kramer (1974) coined the phrase “reality shock”. The purpose of the mentoring program was to bridge the gap between the academic setting and the clinical setting for the NGRN in their first 90-days of practice.

Methods: The mentoring program was presented to prelicensure students during their final semester in nursing school. The mentoring program began when the prelicensure …

A Validation Experiment: Utilizing Ultraviolet Light To Disinfect High Use Nursing Equipment, Gordon West

International Nursing Research Congress (INRC)

Background: Healthcare staff continue to utilize equipment that can travel from patient room to patient room without disinfection or cleaning between use. Additionally, nursing and housekeeping staff may not always communicate clearly regarding responsibilities for cleaning some of these items. The purpose of this study was to identify if a portable UV-C tent utilized with a UV-C device (Xenex® LightStrike™ Robot) can effectively disinfect high use equipment used within inpatient nursing units across a large military medical treatment facility.

Method: Healthcare equipment consisting of commodes, toilet seat risers, wheelchairs, vital sign machines, workstations on wheels, and bassinets were pre swabbed …

“Overpriced & Over Dosed”: Thematic Analysis Of Perceived Root Causes Of Us Maternal Mortality Rate, Emily Richardson, Rebecca Mccann

International Nursing Research Congress (INRC)

Maternal mortality in the United States (US) is a problem of growing concern. In 2021 maternal mortality accounted for 32.9 deaths per 100,000 with non-Hispanic Black clients having a mortality rate of 2.6 times higher than non-Hispanic Whites. Of utmost concern, is the determination that over 80% of pregnancy related deaths were preventable. With the growing press around this topic, the authors sought to analyze the public’s perceived root causes for the increase in poor maternal outcomes. As maternal/ child experts, the authors know that client perception may not always be medically reliable; therefore, this study aims to gain understanding …

Effects Of Chatbot On Surgical Patients: A Systematic Review, Chung Man Ho, Mei Ping Priscilla Choi

International Nursing Research Congress (INRC)

Aim: To evaluate the effectiveness of chatbots in enhancing patient knowledge, alleviating psychological distress, and improving compliance compared to traditional methods among surgical patients.

Design: A systematic review.

Methods: Randomised controlled trials and quasi-experimental studies involving patients undergoing surgeries under general anaesthesia were reviewed. The risk of bias was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials and the Risk of Bias in Non-randomised Studies of Interventions tool for non-randomised controlled trials.

Results: Nine studies with 1476 patients were included in this review. Conversational agents significantly improved perioperative knowledge, psychological distress and compliance with preoperative instructions, …

The Relationship Between The Hesi Integrated Exit Exam & Next Generation Nclex-Rn: Updated, Mamta Shah, Peter Granville, Ryan S. Baker, Michelle Bussard

International Nursing Research Congress (INRC)

Purpose
The purpose of this study was to determine the extent to which the HESI Integrated Exit Exams (E2) can predict nursing students’ first-time pass rates on the Next Generation NCLEX-RN (NGN-RN), expanding on findings reported by Shah et al (2024). Programs typically set a minimum score threshold of 850 or 900 on the E2 to consider students ready for the NCLEX (Olsen et al., 2022). We examined, "If students achieve a benchmark score on the E2, do they pass the NGN-RN on their first attempt?" Previous research has also examined the role of E2 policies and their association with …

Developing A Machine Learning Method To Identify Racial Disparities In End-Stage Kidney Disease, Brandon M. Varilek, Semhar Michael, Hossein Moradi Rekabdarkolaee, Patti J. Brooks, Surachat Ngorsuraches

International Nursing Research Congress (INRC)

End-stage kidney disease (ESKD) disproportionately affects Hispanic and American Indian (AI) persons with prevalence rates more than double of White persons. Furthermore, all-cause mortality is significantly higher for Hispanic and AI. The increased prevalence and mortality rates can be attributed to the higher level of health disparities caused by social determinants of health (SDOH). We are developing machine learning and computational models based on patient-level ESKD data at zip code or county level paired with SDOH data to predict the risk of mortality among Hispanic and AI persons with ESKD in South Dakota who have varying socio-demographic characteristics. The primary …

Full Issue

Indian Journal of Law and Technology

No abstract provided.

Copyright Information

Journal of Science Education for Students with Disabilities

Publication rights to works is granted to Journal of Science Education for Students with Disabilities, however, full copyright for works published in this journal is retained by the author(s). The author(s) may post their works online in an institutional repository, on their University departmental website, or on their own personal websites.

Blood Glucose Concentration In Highly Prolific Sows Before Farrowing: Its Relationship With Parity And Litter Size, Preechaphon Taechamaeteekul, Silvia Comencini, Fabio De Rensis, Roberta Saleri, Padet Tummaruk

The Thai Journal of Veterinary Medicine

Farrowing is an energy-demanding period for prolific sows, with blood glucose levels serving as key indicators affecting farrowing outcomes and piglet survival. This study aimed to evaluate blood glucose levels in prolific sows prior to farrowing, assess the prevalence of hypoglycemia in late gestation, and investigate the relationship between blood glucose levels, parity, and litter size under tropical conditions. A total of 67 Danish Landrace × Yorkshire sows were grouped based on litter size (6–14, 15–17, or ≥18 piglets) and parity (2–4 and 5–6). To determine glucose levels, blood samples were collected at 115.8 ± 1.6 days of gestation, at …

The Green Approach Of Arabic Gum-Based Adsorbent In Wastewater Treatment, Atheel H. Alwash

AUIQ Technical Engineering Science

The natural polysaccharide Arabic gum is a multifunctional, sustainable material used widely in wastewater treatment technology. Its active functional groups such as hydroxyl, carboxyl, and amino groups facilitate the efficient removal of heavy metals, dyes, pesticides, pharmaceuticals, and persistent organic pollutants. The high surface area and active functional groups facilitate its modification to form various structures such as hydrogels, nanocomposites, or biochar integrated into hybrid adsorption–photocatalysis systems. This review highlights the most familiar forms of Arabic gum in wastewater treatment technology, such as hydrogels, hydrogels nanocomposite, stabilizing agents, coating agents, and bio-activated carbon derived from Arabic gum using different preparation …