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Articles 47191 - 47220 of 2913340
Full-Text Articles in Entire DC Network
Usage Statistics: Project Counter R5 Dr_D1 Report Fy2025 - Database Search And Item Usage, Andrée Rathemacher
Usage Statistics: Project Counter R5 Dr_D1 Report Fy2025 - Database Search And Item Usage, Andrée Rathemacher
Technical Services Reports and Statistics
Project COUNTER R5 / R5.1 Report DR_D1 for the University of Rhode Island for the period from July 1, 2024 - June 30, 2025. The DR_D1 report is defined as "Database Search and Item Usage." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.
File for download is Excel spreadsheet generated by Alma Analytics.
Results:
Searches Automated - 38,089
Searches Federated - 1,810
Searches Regular - 1,304,882
Total Item Investigations - 933,864
Total Item Requests - 286,912
Usage Statistics: Project Counter R5 Ir_M1 Report Fy2025 - Multimedia Item Requests, Andrée Rathemacher
Usage Statistics: Project Counter R5 Ir_M1 Report Fy2025 - Multimedia Item Requests, Andrée Rathemacher
Technical Services Reports and Statistics
Project COUNTER R5 / 5.1 Report IR_M1 for the University of Rhode Island for the period from July 1, 2024 - June 30, 2025. The IR_M1 report is defined as "Multimedia Item Requests." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.
File for download is Excel spreadsheet generated by Alma Analytics.
Results:
Total Item Requests - 3,357
Usage Statistics: Project Counter R5 Pr_P1 Report Fy2025 - Platform Usage, Andrée Rathemacher
Usage Statistics: Project Counter R5 Pr_P1 Report Fy2025 - Platform Usage, Andrée Rathemacher
Technical Services Reports and Statistics
Project COUNTER R5 / 5.1 Report PR_P1 for the University of Rhode Island for the period from July 1, 2024 - June 30, 2025. The PR_P1 report is defined as "Platform Usage." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.
File for download is Excel spreadsheet generated by Alma Analytics.
Results:
Searches Platform - 294,352
Total Item Requests - 1,451,061
Unique Item Requests - 1,078,034
Unique Title Requests - 55,776
Usage Statistics: Project Counter R5 Tr_B1 Report Fy2025 - Book Requests Controlled) By Title, Andrée Rathemacher
Usage Statistics: Project Counter R5 Tr_B1 Report Fy2025 - Book Requests Controlled) By Title, Andrée Rathemacher
Technical Services Reports and Statistics
Project COUNTER R5 / 5.1 Report TR_B1 for the University of Rhode Island for the period from July 1, 2024 - June 30, 2025. The TR_B1 report is defined as "Book Requests Controlled)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.
File for download is Excel spreadsheet generated by Alma Analytics.
Results:
Total Item Requests - 194,197
Unique Title Requests - 60,001
Usage Statistics: Project Counter R5 Tr_J1 Report Fy2025 - Journal Requests Controlled) By Platform, Andrée Rathemacher
Usage Statistics: Project Counter R5 Tr_J1 Report Fy2025 - Journal Requests Controlled) By Platform, Andrée Rathemacher
Technical Services Reports and Statistics
Project COUNTER R5 / 5.1 Report TR_J1 for the University of Rhode Island for the period from July 1, 2024 - June 30, 2025. The TR_J1 report is defined as "Journal Requests Controlled)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.
File for download is Excel spreadsheet generated by Alma Analytics.
Results:
Total Item Requests - 850,324
Unique Item Requests - 628,581
Final Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites: Ur-08 (Anderson Shaft) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.
Final Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites: Ur-08 (Anderson Shaft) Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
The Cowl - V. 89 N. 11 - January 22, 2026
The Cowl - V. 89 N. 11 - January 22, 2026
The Cowl
The Cowl - student newspaper of Providence College. Vol. 89 No. 11 - January 22, 2026. 20 pages.
Implementing Emotional Intelligence To Enhance Leadership Abilities In A Skilled Nursing Home, Nkechi Amaechina
Implementing Emotional Intelligence To Enhance Leadership Abilities In A Skilled Nursing Home, Nkechi Amaechina
Walden Dissertations and Doctoral Studies
To meet dynamic changes in healthcare, effective leadership is necessary. A major problem with effective leadership is the lack of emotional intelligence (EI). The purpose of this integrative review is to identify strategies that enhance skilled nursing home leadership abilities using EI. The Leader-Member Exchange (LMX) theory was used, supported by Complex Adaptive Systems (CAS)Theory. LMX theory explains that leaders-members relationships affect an organization while CAS theory describes healthcare industry as ever-changing. The review question (RQ) that guided this integrative review is: what best EI strategies can be implemented to enhance leadership abilities in a skilled nursing home? Twenty-six articles …
Unpacking Domestic Violence Intervention Programs, Lauren Pagan
Unpacking Domestic Violence Intervention Programs, Lauren Pagan
Walden Dissertations and Doctoral Studies
Domestic violence is a public health concern and most existing literature has focused on service delivery for victims, opposed to interventions for perpetrators. The Duluth model is the most common model guiding groups for perpetrators, yet results on its effectiveness have been inconsistent and unclear. Counselors and counselor educators lack the empirical support needed to effectively apply the Duluth model while working with the people who abuse. The purpose of this qualitative, existential–phenomenological study was to explore the lived experiences of participants in Duluth Model-based, domestic violence intervention programs (DVIPs). Guided by existential–phenomenological theory, this study addressed the research question: …
K-8 School Administrators' Implementation Of Positive Behavior Intervention And Support Systems To Reduce Out-Of-School Suspensions In A Southeastern U.S. School District, Chantell H. Walker
K-8 School Administrators' Implementation Of Positive Behavior Intervention And Support Systems To Reduce Out-Of-School Suspensions In A Southeastern U.S. School District, Chantell H. Walker
Walden Dissertations and Doctoral Studies
The problem that was addressed through this study is that the implementation of positive behavior interventions and supports (PBIS) has not resulted in a consistent reduction in the use of out-of-school suspensions as a disciplinary consequence in K–8 schools in a Southeastern U.S. school district. Grounded in Horner and Sugai’s PBIS, the purpose of this qualitative study was to explore K–8 school administrators’ perceptions of their implementation of PBIS in a Southeastern U.S. school district. For this basic qualitative design, semistructured interviews were conducted with three principals and three assistant principals in the local school district. Thematic analysis using inductive …
A Little Blue Hedgehog That Runs A Lot And Has An Attitude: An Analysis Of The Covers Of Archie Comics’ Sonic The Hedgehog, Eleanor Herman
A Little Blue Hedgehog That Runs A Lot And Has An Attitude: An Analysis Of The Covers Of Archie Comics’ Sonic The Hedgehog, Eleanor Herman
Theses and Dissertations
Through the lens of Robin Williams principles of design as outlined in her book, The Non-Designer’s Design Book, this thesis analyzes selected covers of Archie Comics’ Sonic the Hedgehog comic book series to see how the covers evolved over time, as the nearly 25-year continuous run allows for a unique analysis opportunity. 18 issues were selected and analyzed, with conclusions drawn from the covers’ use of contrast, alignment, repetition, and proximity.
No. 111 An Order Amending Executive Order No. 110 To Provide Emergency Transportation Repairs, Bill Lee
No. 111 An Order Amending Executive Order No. 110 To Provide Emergency Transportation Repairs, Bill Lee
Executive Orders
No abstract provided.
No. 110 An Order To Provide Relief In Anticipation Of Severe Winter Weather, Bill Lee
No. 110 An Order To Provide Relief In Anticipation Of Severe Winter Weather, Bill Lee
Executive Orders
No abstract provided.
Nitroarene-Mediated Photo-Oxidative Deconstruction And Upcycling Of Unsaturated Rubber Waste, Junpeng Wang, Zefeng Wang, Roberto Obergon, Obed Fernando
Nitroarene-Mediated Photo-Oxidative Deconstruction And Upcycling Of Unsaturated Rubber Waste, Junpeng Wang, Zefeng Wang, Roberto Obergon, Obed Fernando
University Research
Transforming waste polymers into materials with improved properties offers a compelling strategy for advancing the sustainable use of polymers, echoing the Chinese proverb: “Blue comes from indigo but surpasses it in blueness.” Herein, we report a photo-oxidative deconstruction and upcycling method for unsaturated rubber waste. Under 390 nm LED irradiation at room temperature, in the presence of a nitroarene oxidant, diverse unsaturated polymers─including natural rubber, polybutadiene, nitrile rubber, styrene–butadiene rubber, and even cross-linked nitrile gloves─are selectively converted into carbonyl-terminated oligomers. The aldehyde-functionalized products are cross-linked via dynamic imine chemistry with p-phenylenediamine to yield reprocessable elastomers with markedly improved tensile strength …
Obesity And Long Covid: Intersecting Epidemics?, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein, Inspire Group
Obesity And Long Covid: Intersecting Epidemics?, Michael Gottlieb, Huihui Yu, Ji Chen, Erica S. Spatz, Nicole L. Gentile, Rachel E. Geyer, Michelle Santangelo, Caitlin Malicki, Kristyn Gatling, Kelli N. O'Laughlin, Kari A. Stephens, Joann G. Elmore, Lauren E. Wisk, Michelle L'Hommedieu, Robert M. Rodriguez, Juan Carlos C. Montoy, Ralph C. Wang, Kristin L. Rising, Efrat Kean, Jonathan W. Dyal, Mandy J. Hill, Arjun K. Venkatesh, Robert A. Weinstein, Inspire Group
Jefferson Center for Connected Care Faculty Papers
BACKGROUND: Obesity affects over 10% of the world population and has significant public health implications. With rising recognition of the long-term effects of Long COVID (LC) coupled with new agents to facilitate weight loss, it is critical to understand the influence of obesity on LC. This study assessed the association of obesity with rates of LC and degree of LC-related mental and physical health outcomes among participants up to three years after initial infection.
METHODS: This was a cross-sectional, multisite study of participants with SARS-CoV-2 infection from 12/11/2020–8/29/2022, with data collected through 4/2/2024. Surveys included validated tools for physical and …
Operating On Thin Margins: The Cost Of Providing New Hampshire Child Care, Tyrus Parker, Jess Carson
Operating On Thin Margins: The Cost Of Providing New Hampshire Child Care, Tyrus Parker, Jess Carson
Carsey Publications
In this primer, authors Tyrus Parker and Jess Carson summarize available data on the cost of operating a child care program in New Hampshire. Using data from a 50-state cost calculator as well as three local child care programs, the authors find that despite high child care costs for families, tuition alone is largely insufficient revenue for program operation. As a result, child care program operators must make difficult tradeoffs around program offerings, program quality, and compensation for educators. The authors call for rigorous data collection and modeling to support planning a sustainable financial model for the Granite State’s early …
Strategies Financial Institutions Use To Mitigate Security Breaches For Mobile Customers, Steven F. Knese
Strategies Financial Institutions Use To Mitigate Security Breaches For Mobile Customers, Steven F. Knese
Walden Dissertations and Doctoral Studies
Mobile fraud attack rates are increasing rapidly. Financial institutions, cybersecurity managers, and regulators need effective strategies to reduce consumer financial harm and operational risk. Grounded in the cybernetics model, this qualitative, pragmatic inquiry identified the cybersecurity strategies that cybersecurity professionals use at financial institutions to mitigate data breaches for mobile customers accessing financial data. Data were collected from five cybersecurity professionals through semistructured interviews and from publicly available documents and guidance issued by financial institutions and standards bodies. Six significant themes emerged from thematic analysis: implementing multifactor authentication, deploying virtual private networks (VPNs), delivering user education, promoting regular account monitoring, …
Hiv Pre-Exposure Prophylaxis Uptake And Continuation Among 15-24-Year-Old Women In Mulago, Uganda, Dithan Kiragga
Hiv Pre-Exposure Prophylaxis Uptake And Continuation Among 15-24-Year-Old Women In Mulago, Uganda, Dithan Kiragga
Walden Dissertations and Doctoral Studies
Young women in Uganda face disproportionately high HIV risk compared to the general population. While pre-exposure prophylaxis (PrEP) demonstrates proven effectiveness, poor uptake and nonadherence limit its potential impact. This study examined the relationship between perceived HIV susceptibility, PrEP benefits, behavioral risk factors, service delivery models, and PrEP uptake and continuity among young women aged 15–24 in Uganda, guided by the health belief model. Data were ed from surveillance records at Mulago National Referral Hospital’s STI clinic from January 2024 to September 2025. Of N=23,765 young women screened (median age 21 years; 98.9% single or separated; 48.7% with primary education), …
Association Between The 2022 Aha/Acc/Hfsa Heart Failure Staging And Cardiovascular And Kidney Outcomes In Patients With Diabetes And Kidney Disease: A Post Hoc Analysis Of The Scored Randomized Controlled Trial, Ayodele Odutayo, Deepak L Bhatt, Vikas S Sridhar, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Renato D Lopes, Benjamin M Scirica, Kausik K Ray, Michael J Davies, Phillip Banks, Manon Girard, Subodh Verma, Jacob A Udell, Bertram Pitt, Ph Gabriel Steg, David Z I Cherney
Association Between The 2022 Aha/Acc/Hfsa Heart Failure Staging And Cardiovascular And Kidney Outcomes In Patients With Diabetes And Kidney Disease: A Post Hoc Analysis Of The Scored Randomized Controlled Trial, Ayodele Odutayo, Deepak L Bhatt, Vikas S Sridhar, Michael Szarek, Christopher P Cannon, Lawrence A Leiter, Darren K Mcguire, Julia B Lewis, Renato D Lopes, Benjamin M Scirica, Kausik K Ray, Michael J Davies, Phillip Banks, Manon Girard, Subodh Verma, Jacob A Udell, Bertram Pitt, Ph Gabriel Steg, David Z I Cherney
Faculty, Staff and Student Publications
Background: The 2022 American Heart Association/American College of Cardiology/Heart Failure Society of America heart failure (HF) classification incorporates cardiac biomarkers to identify early risk of HF. The HF stages may also guide the prognosis and management of cardiovascular and kidney-related events.
Methods: SCORED (Effect of Sotagliflozin on Cardiovascular and Renal Events in Patients With Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk) was a randomized trial in diabetes with kidney disease comparing sotagliflozin versus placebo on cardiovascular death, HF hospitalizations, and urgent HF visits. SCORED participants were grouped by HF stage post hoc. Stage A: no …
The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu
The Gene Encoding Ornithine Decarboxylase For Putrescine Biosynthesis Is Essential For The Viability Of Fusobacterium Nucleatum, Shiqi Xu, Bibek G C, Alex Phan, Chenggang Wu
Faculty, Staff and Student Publications
Fusobacterium nucleatum is a Gram-negative anaerobe associated with periodontitis and colorectal cancer. It secretes putrescine, a polyamine that promotes biofilm formation by oral co-colonizers and enhances the proliferation of cancer cells. However, the physiological importance of putrescine for F. nucleatum itself remains unexplored. Here, we show that putrescine biosynthesis, mediated by the ornithine decarboxylase gene oda, is essential for F. nucleatum viability. Deletion of oda was only possible when a functional copy was provided in trans, and CRISPR interference of oda expression resulted in complete growth defects. The essentiality of oda was conserved across multiple subspecies. Supplementation with …
Disease-Specific And Overall Survival For Patients With Lacrimal Gland Adenoid Cystic Carcinoma In Recent Decades, Bita Esmaeli, Zhouxuan Li, Tracy J Lu, Hila Goldberg, Jing Ning, James Matthew Debnam, Steven Jay Frank, Renata Ferrarotto
Disease-Specific And Overall Survival For Patients With Lacrimal Gland Adenoid Cystic Carcinoma In Recent Decades, Bita Esmaeli, Zhouxuan Li, Tracy J Lu, Hila Goldberg, Jing Ning, James Matthew Debnam, Steven Jay Frank, Renata Ferrarotto
Faculty, Staff and Student Publications
Purpose: To evaluate the presenting symptoms, and the overall survival (OS) and disease-specific survival (DSS) in patients with lacrimal gland adenoid cystic carcinoma (LGACC).
Methods: This retrospective single-centre cohort study included all consecutive patients with LGACC treated by the primary author from November 1998 through August 2024. Demographic data, presenting symptoms, the histological subtype of LGACC, type of surgical treatment, adjuvant radiotherapy or chemotherapy, T category at presentation and survival data were reviewed. Correlations between histological subtypes, T-category, type of surgery (eye sparing vs orbital exenteration), and DSS and OS were analysed.
Results: 52 patients had a median age of …
University Medical City Annual Research Day Oman, Convention And Exhibition Centre, 24Th September 2025, Sultan Qaboos University
University Medical City Annual Research Day Oman, Convention And Exhibition Centre, 24Th September 2025, Sultan Qaboos University
Sultan Qaboos University Medical Journal
No abstract provided.
Utah Women In The Workplace: Entrepreneurship, Workforce Development, Stem Fields, And Leadership Development, Susan R. Madsen, April Townsend
Utah Women In The Workplace: Entrepreneurship, Workforce Development, Stem Fields, And Leadership Development, Susan R. Madsen, April Townsend
Marketing and Strategy Faculty Publications
During the fall of 2023, Utah Women & Leadership Project (UWLP) researchers conducted a statewide study to establish a baseline for public perceptions related to the awareness, understanding, and attitudes about challenges that Utah women and girls face. In early 2024, we published 20 short research summaries1 that shared the results of this comprehensive study (see Nos. 9–28). Next, in the fall of 2024, we administered this survey, with slight changes, around the state of Utah for the second time. Six comprehensive research white papers were then published on the results (see Nos. 11, 12, 13, 14, 16, and …
Public Speaking, Demonstration And Action Exhibit Scorecard & Information, Alison Coleman
Public Speaking, Demonstration And Action Exhibit Scorecard & Information, Alison Coleman
UNH Cooperative Extension
No abstract provided.
Exploring Patient, Parent And Clinician Views Of Outcomes For Family-Centered Care In Neonatal Settings: A Qualitative Study, Cousin Study Group, Cansel Kocakabak, Agnes Van Den Hoogen, Jos M. Latour
Exploring Patient, Parent And Clinician Views Of Outcomes For Family-Centered Care In Neonatal Settings: A Qualitative Study, Cousin Study Group, Cansel Kocakabak, Agnes Van Den Hoogen, Jos M. Latour
School of Nursing and Midwifery
Highlights: What are the main findings? Qualitative analysis of family-centered care experiences, drawn from perspectives of parents, a former neonatal patient, and healthcare professionals, identified 42 distinct outcomes which were categorized into five domains. The five domains, with distinct outcomes, highlight the multidimensional family-centered care including: emotional functioning, role functioning, delivery of care, physiological health, and hospital resources. What are the implications of the main findings? These findings show the importance of involving parents, former neonatal patients and healthcare professionals in the development of a robust core outcome set for family-centered care interventions in neonatal settings. The findings provide evidence …
The Spectrum Of Bipolar Disorder In Older Adults, Hui Xin Ng, Martha Sajatovic
The Spectrum Of Bipolar Disorder In Older Adults, Hui Xin Ng, Martha Sajatovic
Faculty Scholarship
The absolute number and relative proportion of individuals with older-age bipolar disorder (OABD) is expected to rise due to the global aging of the population, necessitating a greater understanding of the unique characteristics of OABD and the trajectory of aging with BD in order to improve the health span of people with BD. This review summarizes current knowledge on OABD, examining its clinical presentation, neurobiology, and treatment, as well as identifying key gaps and future directions for research. OABD is characterized by relatively greater cognitive impairment and somatic burden, despite potentially reduced mood symptom severity compared to younger-age bipolar disorder …
Kenyon Collegian - January 22, 2026
Subjective Perspectives On Antarctic Wilderness: An Application Of Integral Ecology, Annabelle G. Mayes
Subjective Perspectives On Antarctic Wilderness: An Application Of Integral Ecology, Annabelle G. Mayes
Honors College Theses
Parties to the Antarctic Treaty have set Antarctica aside for peace, scientific research, and environmental protection. However, they have yet to take concrete actions to protect Antarctica’s wilderness values as agreed under the 1991 Protocol on Environmental Protection to the Antarctic Treaty. Meanwhile, pristine areas that are free from human interference are declining as human activity escalates. This study examines perceptions of Antarctic wilderness through the lens of integral ecology. Data from 1,640 people and 16 study populations were extracted from four published studies. Content analysis was conducted to determine how subjective perspectives differ across populations and geographic regions. All …
Evaluation Of Adalimumab Tapering Regimens In Children And Adolescents With Juvenile Idiopathic Arthritis In Remission: A Simulation Study, Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N Van Den Anker, Marc Pfister, Tatjana Welzel
Evaluation Of Adalimumab Tapering Regimens In Children And Adolescents With Juvenile Idiopathic Arthritis In Remission: A Simulation Study, Dominic S Bräm, Verena Gotta, Gilbert Koch, Klervi Golhen, Andreas Woerner, Andrew Atkinson, Johannes N Van Den Anker, Marc Pfister, Tatjana Welzel
2020-Current year OA Pubs
BACKGROUND: Adalimumab (ADM) in children with juvenile idiopathic arthritis (JIA) is usually dosed using fixed weight-based bands (label dosing: 20 mg for < 30 kg, 40 mg for ≥ 30 kg) every other week (EOW). This has been shown to result in higher exposure after remission than targeted in adult patients with rheumatic diseases (trough concentrations of 2–8 mg/L) suggesting possibility of treatment adjustments and tapering, particularly in children weighing 30 to 50 kg. A pharmacometric simulation study was performed to evaluate different ADM dosing regimens supported by therapeutic drug monitoring (TDM) to provide insights for JIA management in remission. METHODS: This simulation study used a previously established pharmacokinetic ADM model. Simulation scenarios included dose reduction to 30 mg in children 30 to 50 kg and interval extension from 14 to 21 or 28 days. To further personalize ADM dosing and avoid exposure above predefined target range, TDM-guided tapering within mentioned simulation scenarios was investigated, i.e., adjusting dosing interval in children and adolescents whose ADM trough concentrations were above the upper limit of the predefined ADM target range of 9 mg/L. Proportions of virtual patients within the extrapolated target exposure range from adults including a safety-margin, i.e., 4–9 mg/L, were assessed and compared to label dosing, stratified by body weight. RESULTS: In children and adolescents with JIA weighing 30 to 50 kg both, dose interval extension to 21 days and dose reduction to 30 mg EOW increased proportion of patients within predefined target range from 17 - 29% (label dose regimen) to 34–43% or 28–43%, respectively. TDM-guided tapering for patients with trough concentrations > 9 mg/L further increased proportion with target exposure to 56–63% while keeping the proportion of patients with trough concentrations < 2 mg/L similar to label dosing (≤ 2%). CONCLUSION: This simulation study suggests that ADM tapering, in children with JIA who reached remission, may be applicable. Appropriate ADM dose reduction or dose interval extension, especially when supported by TDM, could help to reduce treatment-related and socioeconomic burden, while minimize risk of underexposure. Provided simulation framework can be validated and further fine-tuned once paediatric exposure-response data and target ranges have been established.