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Articles 44821 - 44850 of 2913339
Full-Text Articles in Entire DC Network
Obstructive Sleep Apnea Prediction: A Comprehensive Review And Comparative Study, Thi Khanh Chi Huynh, Amonae Dabbs-Brown, Anna Jurek-Loughrey, James Mulhall, Tuan Dung Pham, Ngoc Phu Doan, Viet Hung Tran, Zichi Zhang, Xuan Hoang Nguyen, Yimeng An, Peixin Li, Phi Hung Nguyen, Thi Linh Hoang, Xinming Shi, Hans Vandierendonck, Sebastien Bailly, Jean-Louis Pépin, Thai Son Mai
Obstructive Sleep Apnea Prediction: A Comprehensive Review And Comparative Study, Thi Khanh Chi Huynh, Amonae Dabbs-Brown, Anna Jurek-Loughrey, James Mulhall, Tuan Dung Pham, Ngoc Phu Doan, Viet Hung Tran, Zichi Zhang, Xuan Hoang Nguyen, Yimeng An, Peixin Li, Phi Hung Nguyen, Thi Linh Hoang, Xinming Shi, Hans Vandierendonck, Sebastien Bailly, Jean-Louis Pépin, Thai Son Mai
Research Collection School Of Computing and Information Systems
Obstructive Sleep Apnea (OSA) is a highly prevalent sleep disorder linked to considerable public health burdens and comorbidities. However, its heterogeneous presentation and the limited accessibility of traditional diagnostic tools such as polysomnography (PSG) lead to widespread underdiagnosis. As a result, artificial intelligence (AI) approaches, including machine learning (ML) and deep learning (DL) models, have attracted attention as an alternative pathway to detection. This paper first provides a comprehensive review of AI-driven OSA diagnosis, covering different diagnosis problems, input-data types, data biases, pre-processing techniques, and model performance. We then leverage the largest clinical dataset used in OSA prediction to date, …
Physics-Informed Self-Supervised Diagnosis Of Rotating Machinery Using Latent Odes And Transformer Encoders, Md Al Amin, Mohammad Shafat Ahsan, Jannatul Maua, Mumtahina Ahmed, Kamruddin Nur
Physics-Informed Self-Supervised Diagnosis Of Rotating Machinery Using Latent Odes And Transformer Encoders, Md Al Amin, Mohammad Shafat Ahsan, Jannatul Maua, Mumtahina Ahmed, Kamruddin Nur
Student Publications [Scholarly]
This paper proposes a novel Physics-Informed Self-Supervised Diagnosis (PI-SSD) framework for rotating machinery fault detection, combining physical modeling, self-supervised representation learning, and uncertainty-aware classification. The architecture integrates a multi-resolution convolutional encoder, a windowed Transformer for temporal context modeling, and a latent neural ordinary differential equation (ODE) module that embeds mechanical priors, such as Jeffcott rotor dynamics, directly into the learning process. A masked segment reconstruction objective enables self-supervised pretraining using unlabeled healthy signals, while an evidential classifier head produces fault probabilities with calibrated uncertainty. We evaluate PI-SSD on two publicly available datasets, the NASA PHM’09 Gearbox dataset and the Aalto …
Geospatial Analysis Of Urban Heat Islands And Heat Vulnerability In Chattogram, Bangladesh: Implications For Public Health Risks, Mst Sanjida Alam
Geospatial Analysis Of Urban Heat Islands And Heat Vulnerability In Chattogram, Bangladesh: Implications For Public Health Risks, Mst Sanjida Alam
Student Publications [Scholarly]
Rapid urbanization and land use change are intensifying the Urban Heat Island (UHI) effect and its associated health risks. It is the most common problem in the cities across the Global South. Chattogram the second-largest city in Bangladesh that has highly urbanized and experiencing transformation of croplands and vegetation into impervious surfaces. The changes contribute to the increase in the surface temperature and vulnerability of urban residents. This study aims to determine spatiotemporal patterns of UHI between 2011 and 2024 and the Heat Vulnerability Index (HVI) for 2024 and its associated health risk of Chattogram District. The HVI was developed …
Montana On Screen: Exploring Film Tourism In Montana, Kika Bradford, Elena Bigart, Melissa Weddell
Montana On Screen: Exploring Film Tourism In Montana, Kika Bradford, Elena Bigart, Melissa Weddell
Institute for Tourism and Recreation Research Publications
This report presents a study exploring how film and TV show exposure influences tourism to Montana, a state long celebrated for its cinematic landscapes and Western heritage. Using data from an online survey of 311 visitors who had both watched a Montana-related production and visited a filming location in the past five years, the research examines visitor profiles, motivations, travel behaviors, spending, and perceptions.
Three-Dimensional Displacement Of Upper Cervical Vertebrae In Severe Mandibular Deviation Caused By Condylar Hyperplasia: A Tomographic Segmentation Study, Claudia Milena Ramírez, Rodrigo Cárdenas-Perilla, Luis Eduardo Almeida, Diego Fernando López
Three-Dimensional Displacement Of Upper Cervical Vertebrae In Severe Mandibular Deviation Caused By Condylar Hyperplasia: A Tomographic Segmentation Study, Claudia Milena Ramírez, Rodrigo Cárdenas-Perilla, Luis Eduardo Almeida, Diego Fernando López
School of Dentistry Faculty Research and Publications
Objective: To evaluate the three-dimensional (3D) angular displacement (Roll, Yaw, and Pitch) of the upper cervical vertebrae (C1, C2, and C3) in patients with severe mandibular deviation (MD) due to condylar hyperplasia (CH), utilizing a computed tomography (CT)-based segmentation approach. Methods: This retrospective cross-sectional study included 50 patients with MD ≥ 6 mm caused by hemimandibular elongation (HE) or a hybrid form (HF) of CH. The skull, mandible, and cervical vertebrae (C1–C3) were segmented using 3D Slicer software. Angular deviations (Pitch, Yaw, Roll) were measured relative to the Frankfurt plane. Patients were categorized by the side of CH (right or …
Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda
Duration And Properties Of The Embedded Phase Of Star Formation In 37 Nearby Galaxies From Phangs-Jwst, Lise Ramambason, Mélanie Chevance, Jaeyeon Kim, Francesco Belfiore, J. M. Diederik Kruijssen, Andrea Romanelli, Amirnezam Amiri, Médéric Boquien, Ryan Chown, Daniel A. Dale, Simthembile Dlamini, Oleg V. Egorov, Ivan Gerasimov, Simon C.O. Glover, Kathryn Grasha, Hamid Hassani, Hwihyun Kim, Kathryn Kreckel, Hannah Koziol, Adam K. Leroy, José Eduardo Méndez-Delgado, Justus Neumann, Lukas Neumann, Hsi An Pan, Debosmita Pathak, Karin Sandstrom, Sumit K. Sarbadhicary, Eva Schinnerer, Jiayi Sun, Jessica Sutter, David A. Thilker, Leonardo Ubeda
Physics and Astronomy Faculty Publications
Light reprocessed by dust grains emitting in the infrared enables the study of the physics at play in dusty embedded regions, where ultraviolet and optical wavelengths are attenuated. Infrared telescopes such as JWST have made it possible to study the earliest feedback phases, when stars are shielded by cocoons of gas and dust. Comprehending this phase is crucial for unravelling the effects of feedback from young stars that leads to their emergence and the dispersal of their host molecular clouds. Here we show that the transition from the embedded to the exposed phase of star formation is short (< 4 Myr) and sometimes almost absent (< 1 Myr) across a sample of 37 nearby star-forming galaxies covering a wide range of morphologies, from massive barred spirals to irregular dwarfs. The short duration of the dust-clearing timescales suggests a predominant role of pre-supernova feedback mechanisms in revealing newborn stars, confirming previous results on smaller samples and allowing, for the first time, a statistical analysis of their dependencies. We find that the timescales associated with mid-infrared emission at 21 μm, tracing a dust-embedded feedback phase, are controlled by a complex interplay between giant molecular cloud properties (masses and velocity dispersions) and galaxy morphology. We report relatively longer durations of the embedded phase of star formation in barred spiral galaxies, while this phase is significantly reduced in low-mass irregular dwarf galaxies. We discuss tentative trends with gas-phase metallicity, which may favor faster cloud dispersal at low metallicities.
Influence Of Superhydrophobic Surface Microstructure On Transient Jet Impingement Cooling, D. Jacob Butterfield, Brian D. Iverson, Daniel Maynes, Julie Crockett
Influence Of Superhydrophobic Surface Microstructure On Transient Jet Impingement Cooling, D. Jacob Butterfield, Brian D. Iverson, Daniel Maynes, Julie Crockett
Faculty Publications
Water jet impingement is an effective method of rapidly cooling a surface, but heat transfer from the surface is highly dependent on the surface condition and properties. Here, the impact of a superhydrophobic (SH) surface on heat transfer to an impinging, axisymmetric, room-temperature water jet with Re=6 x 103to 18 x 103 is explored. SH surfaces are created by etching thin silicon wafers to form different micropatterns (posts or holes). Surfaces are heated to between 200 and 320°C, and the local surface temperature is measured with a thermal camera. The time resolved heat transfer from the surface and …
Comparative Authoritarian Law, Madhav Khosla, Benjamin L. Liebman
Comparative Authoritarian Law, Madhav Khosla, Benjamin L. Liebman
Faculty Scholarship
In recent years, comparative constitutional lawyers have turned their attention to the study of democratic backsliding. However, such scholarship is yet to draw on the now extensive literature on traditional authoritarian systems. The bifurcation of regime type that has structured comparative legal research for decades — for comparative constitutional lawyers and for scholars of specific authoritarian regions — is now under strain. With the global rise of authoritarianism and the growing use of law by authoritarian states, the world is harder to neatly separate into two camps than it once might have been. This Article reflects on how we might …
Does Law Constitute Society?, Jeremy K. Kessler
Does Law Constitute Society?, Jeremy K. Kessler
Faculty Scholarship
The resistance of capitalist inequality to legal reform has led a growing number of scholars to reconsider the explanatory virtues of Marxist legal thought. But what are those virtues? Some scholars hold that what makes Marxist legal thought special is its ability to explain the development of legal relationships in terms of the development of extra-legal relationships — specifically, the relations of production as they adapt to changes in the productive forces. Other scholars argue that this focus on the causal process by which extra-legal change (or stasis) drives legal change (or stasis) is too reductive. They contend that Marxist …
Trump V. Cook And The American Rule Of For-Cause Removal, Jane Manners, Lev Menand
Trump V. Cook And The American Rule Of For-Cause Removal, Jane Manners, Lev Menand
Faculty Scholarship
Halfway through oral argument in Trump v. Cook, Justice Amy Coney Barrett asked Solicitor General John Sauer when a statute authorizing an officer’s removal should be read to require process. “Why shouldn’t we do the same thing that the Shurtleff court did,” Barrett asked, “and say that, well, as we said in Shurtleff, when a statute specifies the grounds for removal, there must be notice and a hearing given?”
In response, Sauer distinguished between statutes authorizing removal for inefficiency, neglect of duty, or malfeasance in office (INM) — which he conceded require process — and statutes using the more …
20 Things You Should Never Say To A Patient, Richard H. Madow Dds
20 Things You Should Never Say To A Patient, Richard H. Madow Dds
The Journal of the Michigan Dental Association
This feature article details the financial advantages of utilizing MDA-endorsed vendors to improve practice profitability. It explains the vetting process performed by volunteers to ensure vendors offer meaningful discounts and vetted solutions. The source highlights specific services, such as PPO fee negotiation, dental marketing, and insurance verifications, which can save a practice over $58,000 annually. By leveraging collective bargaining, members gain access to revenue-boosting solutions without exhaustive trial-and-error searching.
Cybersecurity Risk Shifting, Deborah R. Farringer
Cybersecurity Risk Shifting, Deborah R. Farringer
Vanderbilt Journal of Entertainment & Technology Law
The Change Healthcare cyberattack of 2024 paralyzed the health care system for months, creating an exceedingly far reaching and devastating impact on providers, suppliers, and patients across the country. While the scope of the attack was unprecedented, the cyberattack itself was not new, unique, or isolated. Indeed, this attack came just months after the close of a year in which the United States’ Department of Health and Human Services’ Office for Civil Rights (OCR) recorded the highest number of reported breaches of protected health information and the highest number of breached records. With a medical record fetching nearly four times …
Patients Versus Profits, David A. Simon
Patients Versus Profits, David A. Simon
Vanderbilt Journal of Entertainment & Technology Law
Two motives drive much of American health care. The first is the motive to heal the sick—the patient motive. The second is the motive to generate financial gains—the profit motive. This Article asks the following question: where do these two motives intersect and diverge? Using three emerging technologies as examples, this Article provides a framework for answering this question. It then uses this framework’s insights to explain when and how legal and extra-legal institutions can be used to improve care, either by constraining the profit motive or aligning it more closely with the goals of patient care. This Article concludes …
The Role Of Spatial Abilities In Stem Learning And The Influence Of Individual Differences, Styliani Malkogeorgou
The Role Of Spatial Abilities In Stem Learning And The Influence Of Individual Differences, Styliani Malkogeorgou
Masters
Students’ decisions to pursue education and careers in Science, Technology, Engineering, and Mathematics (STEM) are shaped by an interplay of cognitive, social, and motivational factors. Spatial ability is among the most reliable predictors of STEM success, yet less is known about how it relates to students’ STEM attitudes and aspirations, and whether visuospatial working memory (VSWM) explains this relationship. This study tested the hypotheses that (a) stronger spatial abilities and VSWM would be associated with more positive STEM attitudes and stronger STEM aspirations, and (b) VSWM would mediate the relationship between spatial abilities and STEM attitudes/aspirations, while examining the influence …
Transforming Indigent Appellate Advocacy, Rachel T. Goldberg, Estelle M. Mckee
Transforming Indigent Appellate Advocacy, Rachel T. Goldberg, Estelle M. Mckee
Cornell Law Faculty Publications
Indigent appellate advocacy has long been confined to a narrow, technocratic model—one that prioritizes legal expertise over client autonomy and treats appellate cases solely as isolated legal battles rather than opportunities for systemic change. Unlike their trial-level counterparts, appellate attorneys representing indigent clients have received little scholarly attention, leaving critical questions about client participation, ethical representation, and social justice largely unexplored.
This Article challenges the status quo, arguing that appellate attorneys should rethink their role in ways that empower clients and confront the broader injustices shaping their cases. We introduce two alternative frameworks—client-centered appellate representation and participatory appellate representation—that draw …
“Take A Seat”: Overcoming The Enforceability Challenges Of Crowdsourced Blockchain Arbitration, Anna-Sophie Hochgürtel
“Take A Seat”: Overcoming The Enforceability Challenges Of Crowdsourced Blockchain Arbitration, Anna-Sophie Hochgürtel
Journal of Dispute Resolution
This essay addresses the recent phenomenon of Crowdsourced Blockchain Arbitration (CBA). Within the landscape of new digital dispute resolution tools, I argue that CBA stands out as a cost-effective adjudicative dispute resolution forum for online consumer disputes. I then provide an overview of existing CBA platforms and address the question to what extent CBA constitutes a form of arbitration. Only if it does can CBA arbitration agreements and arbitration awards be enforced domestically and internationally under the New York Convention of 1958. I demonstrate that while CBA proceedings correspond to a conceptual understanding of arbitration, they fall outside the international …
Artificial Neural Network Model For Predicting Fatigue Endurance Limit Of Hot Mix Asphalt Using Uniaxial Tension–Compression Tests, Prashanta Kumar Acharjee, Mayzan Isied, Mena I. Souliman, Sameer Jung Karkl, Tanvir Ahmed, Gokhan Saygili
Artificial Neural Network Model For Predicting Fatigue Endurance Limit Of Hot Mix Asphalt Using Uniaxial Tension–Compression Tests, Prashanta Kumar Acharjee, Mayzan Isied, Mena I. Souliman, Sameer Jung Karkl, Tanvir Ahmed, Gokhan Saygili
Civil Engineering Faculty Publications and Presentations
Fatigue is one of the major distresses occurring in asphalt concrete pavement. Repeated traffic loading causes escalated structural damage which results in the formation of cracks. There is a strain level below which the Hot Mix Asphalt goes under fatigue failure, and it is called endurance limit. In this study, a predictive model is developed to predict endurance limit strain values by using artificial neural network. Uniaxial tension-compression fatigue test results conducted under NCHRP Project 9–44 A were utilized in the model development process. An equation is also extracted from the model along which gives the exact values as the …
Firm-Level Political Risk And Earnings Manipulation, Hui Liang James, Thanh Ngo, Jurica Susnjara
Firm-Level Political Risk And Earnings Manipulation, Hui Liang James, Thanh Ngo, Jurica Susnjara
Accounting, Finance, Information Systems, and Business-Law Faculty Publications and Presentations
Using recently developed proxies for firm-level political risk and earnings manipulation, we test the limited attention theory. Contrary to Hirshleifer and Teoh’s core prediction that investor attention is associated with less managerial manipulation, we find that firm-level political risk, serving as a proxy for investor attention, is positively associated with manipulative earnings management, using both accruals and real activities. The results are robust to alternative proxies for political risk and earnings manipulation, various techniques addressing endogeneity concerns, and subsamples of firms with different earnings manipulation incentives. Moreover, we find that the negative relation between earnings manipulation and subsequent operating performance …
Transcriptomics And Metabolomics Analysis Reveal Cell Subpopulations Of Trophoblast Cells Associated With Preeclampsia, Xiaojun Zhu, Ying Jiang, Lilin Wang, Peiyue Jiang, Zixing Zhong, Hetong Li, Caihong Zheng, Lujiao Chen, Juan Wei, Xishi Lin, Peng Ding, Zehua Dong, Xiaosheng Wang, Qiong Luo
Transcriptomics And Metabolomics Analysis Reveal Cell Subpopulations Of Trophoblast Cells Associated With Preeclampsia, Xiaojun Zhu, Ying Jiang, Lilin Wang, Peiyue Jiang, Zixing Zhong, Hetong Li, Caihong Zheng, Lujiao Chen, Juan Wei, Xishi Lin, Peng Ding, Zehua Dong, Xiaosheng Wang, Qiong Luo
Faculty, Staff and Student Publications
Placental abnormalities are central to preeclampsia (PE), yet the cellular and molecular mechanisms underlying this dysfunction remain unclear. We applied a multi-layered, integrative approach to investigate placental tissue from patients with PE and matched controls. Single-cell RNA sequencing (scRNA-seq; GSE173193) and bulk RNA sequencing (bulk RNA-seq; GSE203507) datasets were obtained from the Gene Expression Omnibus. The scRNA-seq dataset included two PE and two control samples, whereas the bulk RNA-seq dataset focused on eight early-onset PE and five uncomplicated term births. Trophoblast subpopulations were identified via scRNA-seq, and pseudotime analysis was used to trace differentiation trajectories. Differential expression and pathway enrichment …
League Of Women Voters Of The Huntington Area E-Mail Bulletin, February, 2026, League Of Women Voters Of The Huntington Area
League Of Women Voters Of The Huntington Area E-Mail Bulletin, February, 2026, League Of Women Voters Of The Huntington Area
League of Women Voters of the Huntington Area Bulletin 2020 - Present
The periodical is published by the League, which is a nonpartisan political organization that encourages the informed and active participation of citizens in government and influences public policy through education and advocacy.
The Banner - V. 161, No. 2 - (February 2026), Christian Reformed Church In North America
The Banner - V. 161, No. 2 - (February 2026), Christian Reformed Church In North America
The Banner
No abstract provided.
Variation In Food Web Reliance On Green And Brown Energy Pathways Across Ecosystem Gradients, James W. Sturges, W. Ryan James, Ryan J. Rezek, Rolando O. Santos, Mack White, Gina A. Badlowski, Shakira Trabelsi, Jordan Massie, Justin S. Lesser, Joel C. Trexler, James Nelson, Jennifer S. Rehage
Variation In Food Web Reliance On Green And Brown Energy Pathways Across Ecosystem Gradients, James W. Sturges, W. Ryan James, Ryan J. Rezek, Rolando O. Santos, Mack White, Gina A. Badlowski, Shakira Trabelsi, Jordan Massie, Justin S. Lesser, Joel C. Trexler, James Nelson, Jennifer S. Rehage
Marine Science
Aquatic food webs typically include highly coupled fast, ‘green’ energy pathways driven by algae or phytoplankton and slower, ‘brown’ energy channels driven by detritus and terrestrial plants. Quantifying how much energy biological communities obtain from each of these pathways is essential, particularly across multiple interconnected food webs over large areas, because energy dynamics are known to influence ecosystem structure and function. Despite their importance, few studies track variance in energy channel contributions to food webs across interconnected habitats during distinct hydrologic seasons. In this study, we used tri-isotope Bayesian mixing models to quantify seasonal contributions of energy pathways to consumers …
Microtransit In Florida: Strategic Considerations And Research Needs, Jennifer Flynn, Martin Catala, Victoria Perk
Microtransit In Florida: Strategic Considerations And Research Needs, Jennifer Flynn, Martin Catala, Victoria Perk
CUTR Internal Grant Research Program
In response to increasingly dispersed trip patterns, changing travel behavior, and new technology platforms, transit agencies are under pressure to modernize their services to sustain ridership and remain relevant. One strategy gaining traction is microtransit, an on-demand service model that allows riders to request trips (in real time or in advance) and receive service in smaller vehicles that may be shared with other passengers.
Agencies are exploring microtransit to address well-known fixed-route challenges, particularly in low-density areas where limited demand, circuitous routing, and weak pedestrian connectivity can lead to low productivity. By right-sizing service to real-time demand, microtransit can reduce …
2026 February - Mary V. Jordan Center Newsletter, Mary V. Jordan Center, East Tennessee State University
2026 February - Mary V. Jordan Center Newsletter, Mary V. Jordan Center, East Tennessee State University
Mary V. Jordan Center Newsletters
No abstract provided.
Conditions Of Vulnerability: Interpreting Social Condition Discrimination, Colleen Sheppard, Geneviève Plumptre, Hannah Reaburn
Conditions Of Vulnerability: Interpreting Social Condition Discrimination, Colleen Sheppard, Geneviève Plumptre, Hannah Reaburn
Dalhousie Law Journal
At a time of deepening structural inequality, it is important to develop human rights categories that respond to the needs of diverse social groups living in conditions of vulnerability. One source of protection, aimed at countering the exclusion and maltreatment of people who are socially or economically disadvantaged, is the addition of “social condition” as a prohibited ground of discrimination. Québec, the Northwest Territories, and New Brunswick have such protection in their anti-discrimination laws. In this article, we argue that the social condition ground is an important tool for redressing intersectional, group-based vulnerabilities that do not fit readily into traditional …
Clinical Evaluation Of Nasal Swab Specimens In Vtm/Utm And Respdirect Estm Using The Panther Fusion Sars-Cov-2/Flu A/B/Rsv Assay., Salika M. Shakir, Robert K. Mccall, Rangaraj Selvarangan, Dithi Banerjee, Yitz Goldstein, Christine Lansang, Rachel Bogh, Carmelle V. Remillard, Respdirect Clinical Study Group
Clinical Evaluation Of Nasal Swab Specimens In Vtm/Utm And Respdirect Estm Using The Panther Fusion Sars-Cov-2/Flu A/B/Rsv Assay., Salika M. Shakir, Robert K. Mccall, Rangaraj Selvarangan, Dithi Banerjee, Yitz Goldstein, Christine Lansang, Rachel Bogh, Carmelle V. Remillard, Respdirect Clinical Study Group
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Respiratory viral infections by SARS-CoV-2, influenza A and B viruses, and RSV overlap in disease signs and symptomology, but differ in treatment modality. Nasal swab specimens have been shown to be an effective alternative specimen type for SARS-CoV-2 detection.
OBJECTIVES: This study evaluated the performance of the Panther Fusion® SARS-CoV-2/Flu A/B/RSV assay in anterior nasal swab specimens (self- or healthcare professional [HCP]-) collected in either viral/universal (VTM/UTM) transport media or the Hologic® RespDirect® collection kit (RespDirect swab in enhanced specimen transport media [eSTM]).
STUDY DESIGN: A multicenter study was conducted from October 2022 to March 2024. A total of …
Loss Of Ctlh Component Maea Impairs Dna Repair And Replication And Leads To Developmental Delay., Søren H. Hough, Satpal S. Jhujh, Samah W. Awwad, Oliver E. Lewis, Simon Lam, John C. Thomas, Thorsten Mosler, Aldo Bader, Lauren E. Bartik, Shane Mckee, Shivarajan Amudhavalli, Estelle Colin, Nadirah Damseh, Emma Clement, Pilar Cacheiro, Anirban Majumdar, Damian Smedley, Joël Fluss, Rosalinda Giannini, Isabelle Thiffault, Guido Zagnoli Vieira, Rimma Belotserkovskaya, Stephen J Smerdon, Petra Beli, Yaron Galanty, Christopher J. Carnie, Grant S. Stewart, Stephen P. Jackson
Loss Of Ctlh Component Maea Impairs Dna Repair And Replication And Leads To Developmental Delay., Søren H. Hough, Satpal S. Jhujh, Samah W. Awwad, Oliver E. Lewis, Simon Lam, John C. Thomas, Thorsten Mosler, Aldo Bader, Lauren E. Bartik, Shane Mckee, Shivarajan Amudhavalli, Estelle Colin, Nadirah Damseh, Emma Clement, Pilar Cacheiro, Anirban Majumdar, Damian Smedley, Joël Fluss, Rosalinda Giannini, Isabelle Thiffault, Guido Zagnoli Vieira, Rimma Belotserkovskaya, Stephen J Smerdon, Petra Beli, Yaron Galanty, Christopher J. Carnie, Grant S. Stewart, Stephen P. Jackson
Manuscripts, Articles, Book Chapters and Other Papers
Ubiquitin E3 ligases play crucial roles in the DNA damage response (DDR) by modulating the turnover, localization, activation, and interactions of DDR and DNA replication proteins. We performed a CRISPR-Cas9 knockout screen focused on ubiquitin E3 ligases and related proteins with the DNA topoisomerase I inhibitor camptothecin. This led us to establish that MAEA, a core subunit of the CTLH E3 ligase complex, is a critical regulator of homologous recombination and the replication stress response. In tandem, we identified eight patients with variants in MAEA who present with a neurodevelopmental disorder that we term DIADEM (Developmental delay and Intellectual disability …
Diagnostic Challenges Of Anomalous Left Coronary Artery From The Right Pulmonary Artery., Lavina Desai, Sanket Shah, Edo Bedzra, Christopher Mathis
Diagnostic Challenges Of Anomalous Left Coronary Artery From The Right Pulmonary Artery., Lavina Desai, Sanket Shah, Edo Bedzra, Christopher Mathis
Manuscripts, Articles, Book Chapters and Other Papers
• ALCAPA is a rare congenital heart defect seen in about one in 300,000 live births. • ALCARPA is an even rarer subset of ALCAPA with the LCA originating from the RPA. • Few cases report ALCARPA associated with coarctation of the aorta. • Coarctation and VSD may cause PH with antegrade LCA flow. • These defects are hard to diagnose and require coronary imaging before surgery.