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Semi-Quantitative Assay To Measure Urease Activity By Urinary Catheter-Associated Uropathogens, Jesus M Duran Ramirez, Jana Gomez, Chloe L P Obernuefemann, Nathaniel C Gualberto, Jennifer N Walker

2020-Current year OA Pubs

Catheter-associated urinary tract infections (CAUTIs) are one of the most common healthcare-associated infections in the US, accounting for over 1 million cases annually and totaling 450 million USD. CAUTIs have high morbidity and mortality rates and can be caused by a wide range of pathogens, making empiric treatment difficult. Furthermore, when urease-producing uropathogens cause symptomatic CAUTI or asymptomatic catheter colonization, the risk of catheter failure due to blockage increases. The enzyme urease promotes catheter blockage by hydrolyzing urea in urine into ammonia and carbon dioxide, which results in the formation of crystals that coat the catheter surface. If CAUTI is …

Gardnerella Exposures Alter Bladder Gene Expression And Augment Uropathogenic Escherichia Coli Urinary Tract Infection In Mice, Nicole M Gilbert, Valerie P O'Brien, Chevaughn Waller, Ekatherina Batourina, Cathy Lee Mendelsohn, Amanda L Lewis

2020-Current year OA Pubs

The anaerobic actinobacterium

Elevated Axonal Protein Markers Following Repetitive Blast Exposure In Military Personnel, Rany Vorn, Rosanne Naunheim, Chen Lai, Chelsea Wagner, Jessica M Gill

2020-Current year OA Pubs

Blast exposures that occur during training are common in military personnel; however, the biomarkers that relate to these subtle injuries is not well understood. Therefore, the purpose of this study is to identify the acute biomarkers related to blast injury in a cohort of military personnel exposure to blast-related training. Thirty-four military personnel who participated in the training program were included in this study. Blood samples were collected before and after repetitive blast-related training on days 2 (

Glial Dysfunction And Its Contribution To The Pathogenesis Of The Neuronal Ceroid Lipofuscinoses, Keigo Takahashi, Hemanth R Nelvagal, Jenny Lange, Jonathan D Cooper

2020-Current year OA Pubs

While significant efforts have been made in developing pre-clinical treatments for the neuronal ceroid lipofuscinoses (NCLs), many challenges still remain to bring children with NCLs a cure. Devising effective therapeutic strategies for the NCLs will require a better understanding of pathophysiology, but little is known about the mechanisms by which loss of lysosomal proteins causes such devastating neurodegeneration. Research into glial cells including astrocytes, microglia, and oligodendrocytes have revealed many of their critical functions in brain homeostasis and potential contributions to neurodegenerative diseases. Genetically modified mouse models have served as a useful platform to define the disease progression in the …

Multivariate Analysis Of Associations Between Clinical Sequencing And Outcome In Glioblastoma, Peter H Yang, Yu Tao, Jingqin Luo, Mounica Paturu, Hsiang-Chih Lu, Shakti Ramkissoon, Jonathan W Heusel, Eric C Leuthardt, Michael R Chicoine, Joshua L Dowling, Gavin P Dunn, Eric Duncavage, Sonika Dahiya, Arindam R Chattherjee, Albert H Kim

2020-Current year OA Pubs

BACKGROUND: Many factors impact survival in patients with glioblastoma, including age, Karnofsky Performance Status, postoperative chemoradiation,

METHODS: We utilized a widely available diagnostic platform (FoundationOne CDx) to perform high-throughput next-generation sequencing on 185 patients with newly diagnosed glioblastoma in our tertiary care center. We performed multivariate analysis to control for clinical parameters with known impact on survival to elucidate the independent prognostic value of prevalent mutant genes and the independent impact of gross total resection.

RESULTS: When controlling for factors with known prognostic significance including

CONCLUSIONS: This study verifies the independent prognostic value of several mutant genes in glioblastoma. Six …

Risk Based Day-Ahead Energy Resource Management With Renewables Via Computational Intelligence, Pratik Mochi, Kartik S. Pandya, Dharmesh Dabhi, Vipul N. Rajput

Research Outputs: 2025-Present

An indeterminate and variable nature of renewable energy sources like solar photovoltaic, wind power, load consumption, electric vehicles trips and market spot prices, make the operation and control of energy management system quite complex. Also, it is expected that the system should be consistent and resilient in case of extreme events like faults, hurricanes etc. This paper has used the risk based optimization strategies considering uncertainty of aforementioned parameters to minimize the operational cost of the aggregator. A 13-bus practical distribution system with 15-scenarios (03-scenarios as extreme events with high impact) are considered as a test system. WCCI-2018 award winning, …

Hybrid Approach Integrated With Gaussian Process Regression For Condition Monitoring Strategies At The Rotor Side Of A Doubly-Fed Induction Generator, Shuo Zhang, Emma Robinson, Malabika Basu

Research Outputs: 2025-Present

Regression-based Machine Learning (ML) approaches are mainly applied to fit the power curve for the performance evaluation of wind turbines (WTs). Although a fitted power curve is prevalent and straightforward for anomaly detection, it is difficult to identify the fault types at the rotor side of a WT, particularly, because the operation can be dependent on multiple parameters. The present paper suggests an interesting approach towards condition monitoring (CM) and fault diagnosis of a DFIG by only processing rotor currents through several signal processing techniques to recognize and localize miscellaneous electrical disturbances. A non-parametric regression approach, Gaussian process regression (GPR), …

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Sentience Politics : A Fishy Perspective, Culum Brown

Animal Sentience

The plight of fishes has almost certainly got worse since Bentham (1789) coined the phrase “The question is not Can they reason? nor, Can they talk? but Can they suffer?” Despite the fact that fishes are increasingly recognised as sentient animals worthy of protection under animal welfare legislation in many countries around the world, fishing practices are almost universally exempt activities. The human population continues to grow, and, surprisingly, per capita intake of fish is still increasing (FAO 2020). The source of this fish is not wild stocks (catches of which have remained more or less stagnant for …

The Question Is Not “Can Humans Talk?” Or “Can They Suffer?” But “Can They Reason?”, Clive Phillips

Animal Sentience

In their target article, Rowan et al (2022) make a welcome attempt to chart the development of Western progress over the past two hundred years toward formally recognizing that animals feel. They outline the heroic efforts of Compassion in World Farming to gain for animals the status of sentient beings rather than merely human property. A broader view exists, from human prehistory to the present day, in which animals have been (and still are) understood to be sentient by indigenous peoples as well as by some Eastern religions. Growing recognition in the West that animals feel represents a new age …

The Science Of Animal Sentience And The Politics Of Animal Welfare Should Be Kept Separate, Marian Stamp Dawkins

Animal Sentience

Although linked historically by Rowan et al., the scientific study of animal sentience and political campaigns to improve animal welfare should be kept separate, for at least two reasons. First, the separation makes it clear that standards of evidence acceptable for ethical or political decisions on animal welfare can be lower than those required for a rigorously scientific approach to animal sentience. Second, it helps to avoid confirmatory bias in the form of giving undue weight to results that are in line with pre-conceived ideas and political views.

Revisiting Donald Griffin, Founder Of Cognitive Ethology, Carolyn A. Ristau

Animal Sentience

Donald Griffin’s writings, beginning with The Question of Animal Awareness (1976), strove to persuade scientists to study the possibility of animal sentience, the basis of Rowan et al.’s efforts to promote animal well-being. Facing great hostility (but also some acceptance) for his ideas, Griffin initially avoided animal welfare advocacy, fearing it would further undermine his efforts to gain recognition of animal sentience. In later years, however, he began to ponder the ethical implications of animal sentience, intending to study wild elephants’ communication and social behavior to better understand their experienced life and apply it to improving conservation methods. As he …

Motivated Science: What Humans Gain From Denying Animal Sentience, Uri Lifshin

Animal Sentience

Resistance to the idea that non-human animals are sentient resembles erstwhile resistance to the theory that the earth is not the centre of the universe, or that humans evolved from “apes”. All these notions are psychologically threatening. They can remind people of their own creatureliness and mortality and might make them feel guilty or uncertain about their way of life. An honest debate over animal sentience, welfare and rights should consider the human motivation to deprive animals of these things in the first place. I briefly review empirical evidence on the psychological function of denying animal minds.

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A Variable Node Optimization Model For Byzantine Fault Tolerant Systems, Ian Robert Fulton

Masters Theses

“Byzantine Fault Tolerance (BFT) has been a major subject of study over the last two decades with increasing societal dependance on secure, correct, and reliable computer systems and online services. This research presents a model for high-level optimization of emerging systems that rely on these BFT algorithms and use a variable numbers of decision nodes. The model highlights the relationship between the security of a system and its efficiency. Two experiments were performed to determine system performance by varying the number of compromised nodes, decision nodes, and total nodes. They examine the probability that a transaction will be compromised based …

Predicting Radiated Emissions From A Cable Harness Through Component Level Tests, Fuwei Ma

Masters Theses

“In this work, a procedure is developed to predict the radiated emissions from a cable harness using component-level tests. Direct measurement on the engine control unit is utilized to accurately characterize the equivalent common mode source voltages and impedance associated with the device. The cable harness geometry is reduced using the equivalent cable bundle approach by lumping wires according to the source and load impedance compared with characteristic impedance of the harness, which dramatically reduces the measurement effort and allows practical 3D full-wave simulation of the radiated emissions. Radiated emissions are predicted from an engine control unit (ECU) and an …

Zinc Plating From Alkaline Non-Cyanide Bath, Abdul J. Mohammed

Masters Theses

“Alkaline non-cyanide zinc plating baths are preferred when trying to avoid the toxicity of cyanide baths or corrosivity of acid baths. Without additives, alkaline zincate baths produce powdery non-adherent deposits which have no use in commercial plating. Additives must be added at optimum concentrations to produce adherent, bright and uniform zinc deposits. In this study electrochemical tests were used to determine effects of additives on cathodic polarization, throwing power and morphology of deposits. Current density distribution in a unique bath of 37.5 g L^-1 Zn and 210 g L^-1 NaOH was modelled using COMSOL and validated two plating …

Industry 4.0 Remanufacturing: A Novel Approach Towards Smart Remanufacturing, Prashansa Ragampeta

Masters Theses

“Smart remanufacturing has become more popular in recent years as a result of its multiple benefits and the growing need for society to encourage a circular economy that leads to sustainability. One of the most common end-of-life (EoL) choices that can lead to a circular economy is remanufacturing. As a result, at the end-of-life stage of a product, it is critical to prioritize this choice over other accessible options because it is the only recovery option that retains the same quality as a new product. This work focuses on the numerous technologies that can aid in the improvement of smart …

A Convolutional Neural Network (Cnn) For Defect Detection Of Additively Manufactured Parts, Musarrat Farzana Rahman

Masters Theses

“Additive manufacturing (AM) is a layer-by-layer deposition process to fabricate parts with complex geometries. The formation of defects within AM components is a major concern for critical structural and cyclic loading applications. Understanding the mechanisms of defect formation and identifying the defects play an important role in improving the product lifecycle. The convolutional neural network (CNN) has been demonstrated to be an effective deep learning tool for automated detection of defects for both conventional and AM processes. A network with optimized parameters including proper data processing and sampling can improve the performance of the architecture. In this study, for the …

Validation Of Athlet-Cd With Cora-28 Test, Murat Tuter

Masters Theses

“Following the incidents at Chernobyl and Fukushima, severe accidents at nuclear power plants (NPP) have become a global concern. These accidents generally occur because of a failure in the reactor cooling system (RCS) and result in the melting of the reactor core and fission product release. This event is mostly caused by a LOCA, loss of flow accident, station blackout or loss of heat sink. During a severe accident, generation of hydrogen as a result of steam-zircaloy fuel cladding is a significant safety concern. To better understand and prevent the hydrogen generation issue, safety related experiments and safety related codes …

Experimental Optimization Of Simulated Ring Rolling Operation For Heavy Rail Industry, Jacob M. Summers

Masters Theses

“Industrially cast AISI 1070 steel wheel pre-forms from Amsted Rail Co. were experimentally hot rolled to simulate the conditions for industrial wheel rolling. Ring rolling of near net shape castings can improve location specific properties by decreasing segregation, closing porosity, and reducing grain size without the use of multiple forging operations in a traditional forging line. As-cast wheel sections were subjected to thermomechanical processing routes using a 2-high rolling mill in a temperature range of 830°C to 1200°C. The goal being to simulate the ring rolling process and optimize benefits of mechanical properties of the as-rolled steel. Charpy V- and …

Several Problems In Nonlinear Schrödinger Equations, Tim Van Hoose

Masters Theses

“We study several different problems related to nonlinear Schrödinger equations….

We prove several new results for the first equation: a modified scattering result for both an averaged version of the equation and the full equation, as well as a set of Strichartz estimates and a blowup result for the 3d cubic problem.

We also present an exposition of the classical work of Bourgain on invariant measures for the second equation in the mass-subcritical regime”--Abstract, page iv.

Pressure Relief Wells: Analysis Of Subsurface Heterogeneity To Evaluate Relief Well Locations For Mississippi River Levees, Emma Marie Young

Masters Theses

“When designing pressure relief well systems, it is imperative to understand what major geomorphology and heterogenies features are present, such as buried oxbow lakes, especially when the feature is parallel to the source, such as the Mississippi River. When present, there is a notable greater increase in head pressures, especially on the landward tow of the levee. This can cause erosional features that originally thought of to have been protected from by installing pressure relief wells. When comparing the effective hydraulic conductivities of horizontal clay layers and vertical clay layers spanning the length of the model, little to no noticeable …

Controlling Microalloy Interactions On Precipitation, Hot Ductility, And Microstructure -- Mechanical Property Relationships, Madhuri Varadarajan

Masters Theses

“One of the main problems faced in the continuous casting of micro-alloy steels is the formation of transverse cracks. Transverse cracks are surface, or near-surface cracks formed perpendicular to the casting direction. The research focuses on using laboratory hot tensile tests methods to determine the low ductility ranges in high strength steel grades with different micro-alloy additions of titanium, niobium, and vanadium. The hot ductility of commercially produced as-cast slab and beam blank samples was evaluated using two experimental methods: tensile testing utilizing a servo-hydraulic load frame with a resistance furnace and thermomechanical testing using rapid Joule heating. The tests …

Cover And Contents

Turkish Journal of Physics

No abstract provided.

Special Tribute To Melanie T. Ellexson, Dhsc, Mba, Otr/L, Faota

OJOT Sponsor Profiles

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Sharon A. Gutman, Phd, Otr/L, Faota

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Sandra E. Edwards, Ma, Otrl, Faota

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Special Tribute To Emily Schulz, Phd, Otrl

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