Digital Commons Network^™

Increased Virus Dissemination Leads To Enhanced Lung Injury But Not Inflammation During Influenza-Associated Secondary Bacterial Infection, Amanda P Smith, Lindey C Lane, Ivan Ramirez Zuniga, David M Moquin, Peter Vogel, Amber M Smith

2020-Current year OA Pubs

Secondary bacterial infections increase influenza-related morbidity and mortality, particularly if acquired after 5-7 d from the viral onset. Synergistic host responses and direct pathogen-pathogen interactions are thought to lead to a state of hyperinflammation, but the kinetics of the lung pathology have not yet been detailed, and identifying the contribution of different mechanisms to disease is difficult because these may change over time. To address this gap, we examined host-pathogen and lung pathology dynamics following a secondary bacterial infection initiated at different time points after influenza within a murine model. We then used a mathematical approach to quantify the increased …

Sustainability Of Breastfeeding Interventions To Reduce Child Mortality Rates In Low, Middle-Income Countries: A Systematic Review Of Randomized Controlled Trials, Alexis Engelhart, Stacey Mason, Ucheoma Nwaozuru, Chisom Obiezu-Umeh, Victoria Carter, Thembekile Shato, Titilola Gbaja-Biamila, David Oladele, Juliet Iwelunmor

2020-Current year OA Pubs

Child mortality is the lowest it has ever been, but the burden of death in low- and middle-income countries (LMICs) is still prevalent, and the numbers average above the global mean. Breastfeeding contributes to the reduction of child mortality by improving chance of survival beyond childhood. Therefore, it is essential to examine how evidence-based breastfeeding interventions are being maintained in resource-constrained settings. Guided by Scheirer and Dearing's sustainability framework, the aim of this systematic review was to explore how evidence-based breastfeeding interventions implemented to address child mortality in LMICs are sustained. The literature search included randomized controlled trials (RCTs) of …

Preclinical Antibody-Pet Imaging Of Pd-L1, Emma L Brown, Rachel A Deweerd, Abbey Zidel, Patricia M R Pereira

2020-Current year OA Pubs

Programmed cell death protein-1/ligand-1 (PD-1/PD-L1) blockade, including antibody therapeutics, has transformed cancer treatment. However, a major challenge in the field relates to selecting patients who are likely to respond to immune checkpoint inhibitors. Indeed, biopsy-based diagnostic tests to determine immune checkpoint protein levels do not accurately capture the inherent spatial and temporal heterogeneity of PD-L1 tumor expression. As a result, not all PD-L1-positive tumors respond to immunotherapies, and some patients with PD-L1-negative tumors have shown clinical benefits. In 2018, a first-in-human study of the clinically-approved anti-PD-L1 antibody Atezolizumab labeled with the positron emitter zirconium-89 validated the ability of positron emission …

The Human Myocardium Harbors A Population Of Naive B-Cells With A Distinctive Gene Expression Signature Conserved Across Species, Kevin C Bermea, Nicolas Kostelecky, Sylvie T Rousseau, Chieh-Yu Lin, Luigi Adamo

2020-Current year OA Pubs

INTRODUCTION: Cardiac immunology studies in murine models have identified a sizeable population of myocardial B-cells and have shown that its modulation represents a promising strategy to develop novel therapies for heart failure. However, scarce data on B-cells in the human heart leaves unclear whether findings in rodents are relevant to human biology.

METHODS: We performed immunohistochemical stains to characterize the amount and distribution of B-cells in human hearts, analyzing both fresh and post-mortem tissue. To gain insight into the biology of human myocardial B-cells we analyzed publicly-available spatial transcriptomics and single-cell sequencing datasets of myocardial and peripheral blood mononuclear cells …

Ipeds Data Feedback Report, Georgia Southern University

IPEDS Feedback Reports

No abstract provided.

Tracking The Implementation Of A Mental Health Smartphone Application At A Large Tertiary Care Health Network, Jennifer Yoon, Katherine B. Martin Md

USF-LVHN SELECT

No abstract provided.

Addressing Racial Health Disparities In Medicine: A Quality Improvement Project To Improve Healthcare Students’ Knowledge On Racism In Medicine, Matthew Nguyen, Jessica Huang, Shirley Smith

USF-LVHN SELECT

No abstract provided.

Sex Differences In Patients With Suicidal Intent That Are Managed By Toxicologists: An Analysis Of The Toxicology Investigators’ Consortium (Toxic) Registry, Gillian A. Beauchamp Md, Jacob Fishbein, Gregory A. Makar, Rita Pechulis Md, Fccp, Matthew D. Cook Do, Robert D. Cannon Do, Kenneth D. Katz Md, Hope Kincaid Mph, Cph, Jennifer L. Carey, Marna R. Greenberg Do, Mph, Facep

USF-LVHN SELECT

No abstract provided.

Outcomes Of Single-Incision Vs Multiport Laparoscopic Appendectomies In Pediatric Populations At A Single Institution, Tiffany Cheng, Elizabeth Hughes Md, Heather Geist Md, Sarah A. Jones Sapienza Md, Daniel Relles Md, Marybeth Browne Md

USF-LVHN SELECT

No abstract provided.

Cannabinoid Use And Total Hospital Cost In Patients With Cirrhosis: A Study Based On Nationwide Inpatient, Rajesh Essrani Md, Muhammad Usman Zafar, Zahid I. Tarar, Umer Farooq, Jiten Kothadia

Department of Medicine

No abstract provided.

A Shock Through The Heart, Lekha Racharla Do, Zeel Patel Do, Akhil Kher Md, Amogh M. Joshi Do, Amy Goodrich-Harris, Theresa Maitz Do, Daniel Makowski

Department of Medicine

No abstract provided.

Advance (Spring 2022), Georgia Southern Division Of Continuing And Professional Education

Division of Continuing & Professional Education

No abstract provided.

The Cost Implication Of Green Building Materials In The Sustainable Government Green Building Constructions / Maizali Halil Ghazali, Ghazali Maizali Halil

Student Works (2020-2029)

The procurement of work in the public sector that consider environmental criteria to reduce the detrimental consequences of human activity and to protect the environment and natural resources, are referred to government green building construction projects. It entails boosting the efficiency of government building construction projects while also utilizing the public market's potential to change the Malaysian economy into a green economy. As Malaysia's largest technical department, the Public Works Department (JKR) currently lacks cost data that includes green products utilized in JKR projects with green project status. The study's objective was to look into green building issues, assess the …

Development And Validation Of Heptaplex Polymerase Chain Reaction Assay For The Discriminatory Detection Of Selected Meats In Food Products / Syed Muhammad Kamal Uddin, Kamal Uddin Syed Muhammad

Student Works (2020-2029)

Food fraud is one of the most prevalent problems of the present day. It is important for consumers to ascertain the authenticity of the declared ingredients in food products. Beef, buffalo, goat, sheep, chicken, duck, and pork are the heavily consumed meats having enormous importance from nutritional, economic, and cultural/religious viewpoints and are often found to be mutually adulterated in raw and processed states. Available DNA-based approaches for species authentication are commonly based on long DNA markers that can be damaged during food processing, rendering the methods less reliable. The objective of the project is to develop a heptaplex Polymerase …

Internalization Of Appearance Ideals And Not Religiosity Indirectly Impacts The Relationship Between Acculturation And Disordered Eating Risk In South And Southeast Asian Women Living In The United States, Sonakshi Negi, Erik M Benau, Megan Strowger, Anne Claire Grammer, C Alix Timko

2020-Current year OA Pubs

Objective: Studies that examine disordered eating in samples of Asian individuals living in the United States frequently combine all individuals of Asian descent into a single group, which can obscure important differences between groups and their experiences of acculturation. The goal of the present study was to establish the relation of acculturation, internalization of appearance ideals, and religiosity as predicting body dissatisfaction and disordered eating in women of South and Southeast Asian (SSEA) descent.

Method: Women of SSEA descent (

Results: Direct paths from acculturation to both body dissatisfaction and disordered eating were not significant. Thin ideal internalization completely accounted …

Jiann-Ping Hsu College Of Public Health Magazine, Georgia Southern University

College of Public Health: News & Publications

• Message from the Dean: Stuart H. Tedders, PhD
• One-On-One: Marshall in Conversation with Aslan
• Alumni Feature: Improving the Body Art Industry
• Truth is Better than Fiction
• An Invisible Danger
• New Development Council
• The Period Equity Movement
• Averitt Award Winner and Together United
• Our Students Around the World
• Justice, Equity, Diversity & Inclusion
• Center for Addiction Recovery Making an impact: Scholarship recipient named
• Karl E. Peace Center for Biostatistics and Survey Research Working together: Biostatistics collaborations
• Center for Public Health Practice and Research Improving Health Outcomes
• Faculty and Students
• Office of Practice and Research
• College
• Photos

Effects Of Vacancies And Electron Temperature On The Electron Phonon Coupling In Cubic Silicon Carbide And Their Connection To The Inelastic Thermal Spike, Salah Al-Smairat

Doctoral Dissertations

“The electron-phonon interaction is an important interaction in many solids as it influences transport phenomena and related quantities such as the electrical and thermal conductivities, especially in nuclear and space applications. The importance of the electron-phonon interaction in primary damage production in 3C-SiC is the subject of this research.

The electron-phonon coupling factor was calculated using a hybrid Density Functional Perturbation Theory - Classical Electron Gas model. The coupling factor was calculated as a function of electron temperature in pristine and defective 3C-SiC, and relaxed defective cells. The electron-phonon coupling is found to depend strongly on the electronic temperature and …

Ecological Restoration Of Lead/Zinc/Copper Mine Tailings: Phytomanagement And Amendment Strategies To Enhance Substrate Functionality And Biomass Production, Mariam K. Al-Lami

Doctoral Dissertations

“The extreme physiochemical characteristics of mine tailings inhibit microbial processes and natural plant growth. Consequently, vast and numerous tailings sites remain barren for decades and highly susceptible to wind and water erosion. Phytostabilization is a cost-effective and ecologically productive remediation approach; however, tailings revegetation is generally challenging and must often be assisted with appropriate soil amendments. Amendments applied individually in greenhouse studies discussed herein revealed notable improvement in bioenergy crops growth only with biosolids treatments. Recalcitrant carbon amendments (biochar and humus) showed notable impact only on tailings physichochemical and hydraulic properties. Nevertheless, biosolids may not support sustained vegetation due to …

The Utilization And Loss Of Available Energy In Aerospace Systems, Mohammad Abbas

Doctoral Dissertations

“Theoretical principles and analytical methodology for the control volume-based energy availability methodology for aerospace vehicles are developed; applications are made to jet-propelled and rocket-propelled vehicles as well as to stand-alone engine systems. Energy availability utilization characteristics of a modeled turbojet engine are studied across a wide range of operating conditions of throttle setting, flight altitude, and flight Mach number. The method is also extended to consider jet-powered vehicles. Fundamental principles regarding entropy generation and energy availability are developed, including directly linking entropy generation and maximum range and endurance of a powered aircraft. Theory and application of the energy utilization methodology …

Representation Learning On Heterogeneous Spatiotemporal Networks, Dakshak Keerthi Chandra

Doctoral Dissertations

“The problem of learning latent representations of heterogeneous networks with spatial and temporal attributes has been gaining traction in recent years, given its myriad of real-world applications. Most systems with applications in the field of transportation, urban economics, medical information, online e-commerce, etc., handle big data that can be structured into Spatiotemporal Heterogeneous Networks (SHNs), thereby making efficient analysis of these networks extremely vital. In recent years, representation learning models have proven to be quite efficient in capturing effective lower-dimensional representations of data. But, capturing efficient representations of SHNs continues to pose a challenge for the following reasons: (i) Spatiotemporal …

Corrosion Protection Mechanisms Of Trivalent Chromium Based Passivations On Γ-Znni Coated Al6061-T6 Alloy, Kevin Foster

Doctoral Dissertations

“The role of cobalt in trivalent chromium passivations (TCPs) to improve corrosion resistance of γ-ZnNi coated steel and aluminum is based on its effect on hexavalent chromium content in the passive layer. Investigations of both a cobalt-containing and cobalt-free TCP on SAE 1008 steel indicated that both passivations protect well for up to 1000 hours in neutral salt spray exposure (SSE). A repetition on Al 6061-T6 alloy indicated that TCP performed much better than cobalt-free TCP implicating the underlying substrate. Optical and electron micrographs indicated physical changes such as crack thickness, crack density, passivation porosity, and passivation thickness existed between …

Post-Seismic Response And Repair Of Earthquake-Damaged Reinforced Concrete Bridges, Giacomo Fraioli

Doctoral Dissertations

“In bridge structures, column members are typically designed to be the primary source of energy dissipation during an earthquake. Therefore, reinforced concrete (RC) bridges that are damaged in an earthquake tend to have damage to the column members. While many studies have been conducted on seismic strengthening of RC bridge columns, most are focused on retrofit instead of repair. In addition, the limited research on seismic repair of RC bridges has focused on evaluating the response of individual columns (member level), not the bridge structure (system level), due to limitations in modeling and especially testing of full bridge structures. Local …

Theoretical And Experimental Application Of Neural Networks In Spaceflight Control Systems, Pavel Galchenko

Doctoral Dissertations

“Spaceflight systems can enable advanced mission concepts that can help expand our understanding of the universe. To achieve the objectives of these missions, spaceflight systems typically leverage guidance and control systems to maintain some desired path and/or orientation of their scientific instrumentation. A deep understanding of the natural dynamics of the environment in which these spaceflight systems operate is required to design control systems capable of achieving the desired scientific objectives. However, mitigating strategies are critically important when these dynamics are unknown or poorly understood and/or modelled. This research introduces two neural network methodologies to control the translation and rotation …

Modeling Strategy For Emi Filter And Flyback Transformer, Ruijie He

Doctoral Dissertations

“The switch-mode power supply is key to miniaturizing power adapters. However, the switching nature of the circuit introduces issues in conducted emissions. In a flyback converter, the transformer serves as the path for common mode current flowing from the primary side to the secondary side. Different winding technologies have been invented and implemented to reduce the capacitance between the primary side and the secondary side. But the repeatability of the winding is still poor due to the fluctuations of the winding machine. Thus, the resulting conducted emission has a fluctuation that can lead to failure in the compliance tests. EMI …

Characterization And Utilization Of Alkali-Activated Concrete For Sustainable Infrastructures, Eslam Gomaa

Doctoral Dissertations

“This study has investigated the feasibility of using locally available fly ashes (FAs) to synthesize alkali-activated concrete (AAC) for different structural and repair applications. Using AAC made of 100% FA reduces global CO2 emissions, saves energy, and decreases raw material consumption during the production process of ordinary Portland cement. Class C FAs, sourced from Labadie, Jeffery City, Kansas City, Thomas Hill, and Sikeston power plants in the state of Missouri, were used to synthesize the AAC. Sodium silicate (SS), Na2SiO3, and sodium hydroxide (SH), NaOH were used as the alkali activators. Slag, crumb rubber, and air-entraining admixture were used as …

Characterizing And Modeling Methods For Power Converters, Anfeng Huang

Doctoral Dissertations

“Stable power delivery is becoming increasingly important in modern electronic devices, especially in applications with stringent requirements of its form factor. With the evolution of technology, the switching frequency in a power converter is pushed to a higher frequency range, e.g., several MHz or even higher, to decrease its size. However, the loss generated in the converter increases drastically due to the high switching frequency. In addition, a wide-band feedback controller is required to accommodate the high switching frequency in the converter. We focus on the characterization or modeling of the feedback control circuits and critical components in a switching …

The Kanarra Fold-Thrust System -- The Leading Edge Of The Sevier Fold-Thrust Belt, Southwest Utah, William Joseph Michael Chandonia

Doctoral Dissertations

“The Jurassic to Eocene Sevier fold-thrust belt is the subject of continued scientific curiosity in tectonics, stratigraphy, and industry. Understanding its development in southwest Utah is hindered in part due to the multiple origins proposed for the Kanarra anticline, a major leading edge structure -- a drag fold along the Hurricane fault, Laramide monocline, Sevier fault propagation fold, or a combination of these -- which have confused its tectonic significance and regional context. This confusion results from the structural complexity of its exposed eastern limb, as well as displacement and burial of its crest and western limb beneath Neogene sediments …

Numerical Simulation Study Of Gel Treatment For Conformance Control From Lab To Field, Jianqiao Leng

Doctoral Dissertations

“Gel treatment has been widely applied to control reservoir conformance and thus improve the sweep efficiency of injection fluids. Quite a few numerical simulations have been conducted to investigate the factors impacting gel treatment and assist to optimize treatment design and predict the performance. However, there exists significant barrier between the simulation approaches and lab experiments. In this study, two comprehensive reviews have been conducted to identify the gaps between lab and current simulations for in-situ polymer treatment and preformed particle gel treatment, separately.

Based on the identified gaps, the effect of a few major factors which are very important …

Mechanical Properties Of Boride Based Ceramics, Alec Murchie

Doctoral Dissertations

“This research focuses on the elevated mechanical properties of diboride based materials at room and elevated temperatures. These materials include a ZrB₂ ceramic, a ZrB₂-WC-SiC ceramic, and a (Hf,Mo,Nb,Ta,W,Zr)B₂ high entropy boride (HEB). The room temperature flexural strength for the ZrB₂ ceramic was 447 MPa and the fracture toughness was 2.3 MPa·m^1/2. The strength decreased to 196 MPa at 1800°C, and then increased to 360 MPa at 2300°C. The fracture toughness increased to 3.1 MPa·m^1/2 at 2200°C. The strength up to 1800°C was likely controlled by a combination of effects: surface damage …

Scale Formation, Properties And De-Scaling In Steelmaking, Richard Osei

Doctoral Dissertations

During continuous castings, reheating, and hot rolling, slab surfaces are exposed to atmospheres containing oxidizing gases which results in scale formation. Inefficient removal of the formed scale during reheating affects product surface quality. The effect of steel composition and operating parameters on scale formation and scale removal efficiencies were investigated. Experimental investigations were carried out using a thermogravimetric (TGA) apparatus designed to replicate the combustion gas atmosphere and temperature in actual industrial slab reheat furnaces. Report on oxidation kinetics, scale structure and properties, and descaling were conducted on laboratory cast and industrial samples. Different characterization techniques were used to analyze …