Digital Commons Network^™

Geometric Properties Of Weighted Projective Space Simplices, Derek Hanely

Theses and Dissertations--Mathematics

A long-standing conjecture in geometric combinatorics entails the interplay between three properties of lattice polytopes: reflexivity, the integer decomposition property (IDP), and the unimodality of Ehrhart h*-vectors. Motivated by this conjecture, this dissertation explores geometric properties of weighted projective space simplices, a class of lattice simplices related to weighted projective spaces.

In the first part of this dissertation, we are interested in which IDP reflexive lattice polytopes admit regular unimodular triangulations. Let Delta_(1,q)denote the simplex corresponding to the associated weighted projective space whose weights are given by the vector (1,q). Focusing on the case where Delta …

The Impacts Of Public Policies On Health-Related Outcomes, Yaxiang Song

Theses and Dissertations--Economics

This dissertation consists of three chapters that study how public policies affect health-related outcomes in China. The first two papers examine the impacts of the country’s Critical Illness Insurance program on health-related outcomes. The third paper studies the effects of maternal education on children’s early childhood health outcomes and cognitive skills.

The first chapter evaluates the impact of a recent social health insurance benefits expansion program on middle-aged and elderly individuals. In 2012, China launched a Critical Illness Insurance (CII) program, which aimed to reduce out-of-pocket costs for individuals covered by the government’s health insurance programs. This chapter utilizes the …

Safety In The Woods: Studying The Effectiveness Of The Kentucky Master Logger Program, Austin Winn Leake

Theses and Dissertations--Community & Leadership Development

Logging is a dangerous field; in this study the researcher looks to see the knowledge both before and after professional loggers participate in the Kentucky Master Logger Program. This information was used to see the overall effectiveness of the Kentucky Master Logger Program. The researcher found an overall improvement in logging professionals’ perceptions and understanding of logging safety. The researcher recommends creating an emphasis on a safe work culture through safety incentives and a greater focus on less used personal protective equipment such as insecticide

Significant Life Experiences Of Kentucky Youth Climate Activists, Jeri Katherine Howell

Theses and Dissertations--Community & Leadership Development

The purpose of this study is to better understand Kentucky youth climate activism. The research questions explore how youth define their climate activism in Kentucky, their Significant Life Experiences (SLE) that motivated them to commit to climate activism, and what challenges and sustains their involvement. This qualitative study utilizes a blended framework of social/environmental positionality and political ecology to analyze 7 semi-structured interviews with participants between the ages 18 to 24 years old who are acting to address climate change in Kentucky. New contributions to the existing body of SLE literature are discussed.

The Resiliency And Thriving Of Underrepresented Agricultural Educators: A National Mixed Methods Study, Caleb Michael Hickman

Theses and Dissertations--Community & Leadership Development

Gay men in agricultural education do not have comprehensive support within the agricultural education profession. When gay men decide to become agriculture educators, they often keep their identity private. This national mixed methods study aims to seek if gay agriculture educators are resilient and thrive in rural communities. The thriving elements of spiritual influence, personal competence, peer support, and family cohesion were surveyed and analyzed using a resiliency lens. Findings include gay male agricultural educators thriving in a heteronormative profession. Recommendations include ensuring LGBTQIA+ teachers have a voice in agricultural education.

Examining Social Mission In Kentucky Social Enterprises, Bo Milburn

Theses and Dissertations--Community & Leadership Development

Social Enterprises are business entities that incorporate social value creation into their business operations. This study aims to investigate, explore and share key insights gained through the lived experience of owners or managers of these organizations. The reputational method of sample selection was used to identify informed individuals who participated in interviews to share phenomenological knowledge by telling the stories of their organizations, describing how they manage the balance between profitability and sustainability, sharing observations about the influence of social mission at their firms and other insights. Participants identified stronger relationships between coworkers, increased professional creativity, and greater employee engagement …

Out Of Sight, Out Of Mind: An Evaluation Of Secondary Agricultural Textbooks, Tara Elizabeth Rojas

Theses and Dissertations--Community & Leadership Development

Students are impacted by representation present within their lives in the media they consume, organizations in which they participate, and school interactions. Among school interactions with primarily White school staff, students interact with textbooks to learn about industry norms and concepts. Missing representation can harm students’ sense of belonging which can lead to feelings like solo-status or isolation. Using both critical race theory and social semiotics, this work explores the representation present within secondary agricultural textbooks. The first study utilizes photos and case studies, observing both gender and race as mutually exclusive variables and compares data to the current public-school …

The Youth - Adult Partnership Between Secondary Agriculture Educators And Native American Youth: A Qualitative Case Study, Hunter Anne Julian

Theses and Dissertations--Community & Leadership Development

This case study examines the connection made between secondary agriculture educators through Youth-Adult Partnerships (YAP). This study provides insight into the elements of YAP and contributes to the limited body of research surrounding Youth-Adult Partnership in secondary agriculture education and in the Native American community. Data was collected through qualitative interviews of six agriculture educators teaching on Native American reservations. The findings of this study indicate that YAP is present in secondary agriculture education programs and offers insight into how agriculture educators form connections with the Native American communities they teach in.

Trem2: Gene Expression And Role In Alzheimer’S Disease, Henry Snider

Theses and Dissertations--Medical Sciences

Genetic mutations in the TREM2 gene are highly correlated with risk of Alzheimer’s disease, but alternative splicing patterns of TREM2 transcripts have not been fully described. Characterization of TREM2 alternative splicing will be of significant use to the scientific community as the field of Alzheimer’s disease research progresses. The goal of this study was to fully describe splicing patterns in TREM2, as different splicing isoforms of genes can alter express and/or function of the final protein. Human blood and anterior cingulate cortex brain tissue from 61 individual donors was processed and used for PCR and quantitative PCR as well as …

Peripheral And Central Glucose Flux In Type I Diabetes, Jelena Anna Juras

Theses and Dissertations--Neuroscience

Diabetes is a complex metabolic disorder, of which high blood glucose concentration is the primary hallmark. Type I diabetes mellitus (T1DM) is characterized by the lack of insulin production, due to a poorly understood autoinflammatory cascade. In the words of historian Barnett “Diabetes may no longer be a death sentence, but for more and more people in the 21st century, it will become a life sentence”, making it the focal point of many research groups. It is estimated that around 20 million individuals worldwide live with T1DM.

Effects of long-term chronically elevated blood glucose are not only seen in micro/macro-vascular …

Interleukin-1 Receptor 1 Signaling In Mild Tbi: Do Endothelial Cells Play A Major Role?, Colleen N. Bodnar

Theses and Dissertations--Neuroscience

Across the world, over 69 million people sustain a traumatic brain injury (TBI) per year making TBI a major health concern worldwide. Of all the TBIs that occur each year, it is suggested that up to 90 percent are mild in nature. Even a mild TBI causes both physical damages to the cells of the brain and activation of a variety of biochemical cascades. Inflammation is an extremely common pathology seen in the brains of TBI survivors of all severities. Chronic inflammation can cause detrimental effects within the brain including neurodegeneration. A major pro-inflammatory cytokine, interleukin-1 (IL-1), is upregulated within …

Conceptualizing Attorney Motivation: A Study Of The Representatives For Parents And Children In The Child Welfare System, Shannon Moody

Theses and Dissertations--Social Work

Background. Attorneys who represent parents and children in dependency, neglect, and abuse (DNA) proceedings are key in influencing the outcomes of the cases they carry. These influences include the length of time a child spends in the custody of the state or the necessity for foster care, visitation with family members, length of time to reunification, and recommended services for the child and parents (Courtney & Hook, 2012; Goldman, 1993; Thornton & Gwin, 2012; Zinn & Peters, 2015). The American Bar Association’s analysis is that there are “four constants: high caseloads, low compensation, inadequate training, and lack of supervision” …

An Investigation Of The Effects Of Psychological And Social Factors On Labor Market Integration In A Gender Stratified Sample Of Refugees In Germany, Theresia M. Pachner

Theses and Dissertations--Social Work

Refugees are disproportionally more likely to be unemployed. Additionally, women have a higher unemployment rate than men. Prospective gender-stratified research on refugee labor market integration is both rare and needed. The goal of this dissertation was to determine the effects of psychological, social, and demographic factors on employment outcomes within a gender-specific framework.

This secondary data study used data from a representative longitudinal panel study of refugees in Germany. Data spanned two years with collection at two time-points (T1 and T2) including baseline (T1) and one year later (T2). Using a complex samples framework in SPSS, logistic regression analyses were …

Three Essays On The Economic Implications Of Oil Shocks, Ryan Hanson

Theses and Dissertations--Economics

My dissertation consists of three papers on the response of various economic indicators to crude oil shocks. In the first paper, I investigate the Western Australian gasoline market for asymmetric responses in gasoline prices to changes in input costs, otherwise known as the rockets and feathers hypothesis. This theory states that after a positive cost shock, firms will swiftly increase their retail prices to consumers; after a decrease in input costs, however, they take longer to adjust and lower prices. Using daily, establishment level data, I estimate a multi-stage error correction model and find evidence of asymmetric price adjustment in …

Essays On Immigration Policy, Andres Felipe Mira

Theses and Dissertations--Economics

Considerable interest has been placed on the subject of what to do with the sizable undocumented population currently residing in the United States. Having a full understanding of the size of this population and the impact immigration policy has on them is of critical importance to policy makers. Data limitations in nationally-representative surveys have limited the analyzes of the effects of immigration policy in the academic literature. As such, this dissertation consists of three essays contributing to the literature on the impact of immigration policy and on identifying unobserved populations.

In my first essay, I examine the labor market response …

Establishment And Verification Of A Sars Cov2 Antibody Detection Assay Comparing Venous And Mitra Samples, Stephen C. Mayer

Theses and Dissertations--Medical Sciences

During the COVID-19 pandemic in 2020, the need for highly-specific, wide-spread, and rapid serological testing surged. In this study, we showed very strong positive correlation between venous blood collection and Mitra home sampling kits for the detection of anti- spike IgGs using an in-house ELISA protocol (based on a protocol from Mt. Sinai). This study demonstrates the utility of using at-home, patient-centric testing to enhance the sero-surveillance methods currently in place for viral tracking and monitoring.

Multivariate Statistical Modeling For Radio-Genomics Study, Tiantian Zeng

Theses and Dissertations--Statistics

Radiogenomics is a new direction in cancer research that focuses on the associations among radiomics, genomics and clinical outcome. Currently, the major challenge for Radiogenomics lies in the effective integration of genomics and imaging data for promising clinical outcome prediction. Herein, we propose a multivariate joint model that can integrate imaging and genomic data for better predicting the clinical outcome. Specifically, we jointly consider two multivariate group lasso models, one regresses imaging features on genomic features, and the other regresses patient’s clinical outcome on genomic features. An L1 penalty term is introduced for each variable, and weight in the penalty …

Deriving The Distributions And Developing Methods Of Inference For R2-Type Measures, With Applications To Big Data Analysis, Gregory S. Hawk

Theses and Dissertations--Statistics

As computing capabilities and cloud-enhanced data sharing has accelerated exponentially in the 21st century, our access to Big Data has revolutionized the way we see data around the world, from healthcare to investments to manufacturing to retail and supply-chain. In many areas of research, however, the cost of obtaining each data point makes more than just a few observations impossible. While machine learning and artificial intelligence (AI) are improving our ability to make predictions from datasets, we need better statistical methods to improve our ability to understand and translate models into meaningful and actionable insights.

A central goal in the …

Beta Mixture And Contaminated Model With Constraints And Application With Micro-Array Data, Ya Qi

Theses and Dissertations--Statistics

This dissertation research is concentrated on the Contaminated Beta(CB) model and its application in micro-array data analysis. Modified Likelihood Ratio Test (MLRT) introduced by [Chen et al., 2001] is used for testing the omnibus null hypothesis of no contamination of Beta(1,1)([Dai and Charnigo, 2008]). We design constraints for two-component CB model, which put the mode toward the left end of the distribution to reflect the abundance of small p-values of micro-array data, to increase the test power. A three-component CB model might be useful when distinguishing high differentially expressed genes and moderate differentially expressed genes. If the null hypothesis above …

Parental Barriers Toward Seeking Mental Healthcare For Saudi Children At Risk Of Adhd, Amani Kappi

Theses and Dissertations--Nursing

Attention deficit hyperactivity disorder (ADHD) is a mental health disorder commonly diagnosed in childhood. Underdiagnosis and undertreatment of ADHD can lead to the development of other mental illnesses and disruptions in social functioning in adulthood. Therefore, parents can play a crucial role in proactively seeking mental healthcare for children who are at risk for or who have a clear diagnosis of ADHD. Studies in the United Kingdom and the United States highlight many barriers that prevent parents from seeking mental healthcare for their children, such as negative attitudes towards the mental healthcare system and stigma towards mental illnesses.

Cultural differences …

Describing And Predicting Preprocedural Anxiety In Patients Scheduled For Advanced Gastrointestinal Endoscopy During The Covid-19 Pandemic, Dawn Profit

Theses and Dissertations--Nursing

Advanced gastrointestinal endoscopy includes a group of specialized procedures and interventions that are being performed more frequently with little attention given to a patient’s preprocedural anxiety issues. Preprocedural anxiety is an anticipated problem with any surgery or invasive procedure and if sustained or experienced excessively, is associated with negative clinical factors and complications.

In the beginning of 2020, the United States was met with a global pandemic caused by the coronavirus SARS-CoV-2, termed COVID-19. There were recommendations to decrease medical procedural case volume in order to slow the spread of the virus, protect staff and patients from getting the virus, …

Development And Psychometric Testing Of An Instrument To Identify Factors That Predict Intentions Related To Post-Mortem Organ Donation Among Saudi Arabian Nurses, Salman Alreshidi

Theses and Dissertations--Nursing

Organ donation shortage is a major international concern. Global data on organ donation and transplantation activities from the World Health Organization indicate that in 2019 organs were available for less than 10% of transplantations needed. In Saudi Arabia alone, the organ donation shortage accounts for 28.8% of deaths annually. Nearly 31% of donated organs are from donors outside of the country because many eligible donors in Saudi Arabia do not donate.

While post-mortem organ donation has the potential to increase available organs for transplantation, in many countries, including Saudi Arabia, hesitancy among candidate donors and their family members can present …

Building Tools For Improved Modulation Of The Human Gabaa Receptor, A Central Nervous System Target For The Treatment Of Anxiety, Garrett Edward Zinck

Theses and Dissertations--Pharmacy

In the U.S., anxiety is recognized as an increasing range of mentally and physically debilitating psychiatric health disorders with significant economic repercussions. Over the last 20 years, several novel anti-anxiety therapies have entered the drug development pipeline, but none have made it to market.

The work in this dissertation focused on structurally modifying valerenic acid (VA), a structurally unique carboxylated sesquiterpene acid found in Valeriana officinalis. VA is putatively reported to have allosteric modulatory activity of the human GABA_A receptor, a ligand-gated ion channel responsible for attenuating neurotransmissions. Structural modeling of VA’s GABA_A receptor interaction suggests that …

Analysis Of Potential Facilitators To Use Of Hiv Pre-Exposure Prophylaxis (Prep) In A Young Transgender Population, Noah Dixon

Theses and Dissertations--Pharmacy

Pre-exposure prophylaxis for HIV prevention (PrEP) is heavily under-utilized in transgender youth, a population which experiences high risk factors for contracting HIV and exhibits unique barriers to care. This retrospective study used a secondary data analysis of survey results from transgender youth between 16-and 24-years-old to analyze various exposures for association with PrEP use. It was hypothesized that medical gender affirming therapy, mental health care treatment, and HIV programming would be independently associated with increased use of PrEP in transgender youth. It was found that only HIV prevention services and programming related to HIV or gender identity were associated with …

The Relative Contribution Of Liver And Intestine In Reverse Cholesterol Transport, Rupinder Kaur

Theses and Dissertations--Pharmacy

Despite decades of advances in research, death due to cardiometabolic disease remains the largest contributor to mortality in the US. While present therapies oppose “forward cholesterol transport,” and atherosclerotic plaque progression, they do not remove cholesterol from established atherosclerotic plaques. Reverse cholesterol transport (RCT) is the active process of mobilizing peripheral cholesterol for excretion through the hepatobiliary (transhepatic cholesterol elimination, THCE) or intestinal (transintestinal cholesterol elimination, TICE) pathways. Currently, there are no clinically approved therapeutics that target RCT. Elucidation of the mechanisms that govern RCT and TICE, and the subsequent identification of novel targets is of importance. The present work …

Development Of Accurate And Efficient Computational Methodologies For Predicting Protein-Ligand And Protein-Protein Binding Free Energies, Alexander Hamilton Williams

Theses and Dissertations--Pharmacy

Computational modeling is an invaluable tool in the drug discovery process either for small ligand or protein therapeutics. The widespread availability of protein X-Ray Crystal and Cryo-Electron Microscopy (Cryo-EM) structures has allowed for more accurate molecular dynamics (MD) simulations that are not reliant on methods such as homology modeling, which may produce structures that require significant computational time to demonstrate their stability. In this thesis we describe several novel methodologies for the computationally efficient modeling of protein/ligand and protein/protein complexes that may be employed within both large-scale virtual screenings and lead compound optimization. These methodologies may also be utilized in …

Development Of Zafirlukast Derivatives Active Against Porphyromonas Gingivalis, Kaitlind C. Howard

Theses and Dissertations--Pharmacy

Periodontal diseases are inflammatory diseases that can lead to damage of the soft tissue and bone supporting the teeth. Gingivitis is the reversible early stage of gum disease, which consist of gums that bleed when brushing or flossing teeth. When left untreated, the preventable but irreversible late stage of periodontal disease, periodontitis, can lead teeth to loosen or even fall out. Oral bacterial species, such as the Gram-negative anaerobic pathogen Porphyromonas gingivalis trigger these inflammatory diseases through oral dysbiosis. P. gingivalis is a keystone pathogen, meaning that the damage caused by P. gingivalis is not proportional to its abundance. Treatment …

Addressing Ascertainment Bias In The Study Of Cardiovascular Disease Burden In Opioid Use Disorders - Application Of Natural Language Processing Of Electronic Health Records, Jade Huang Singleton

Theses and Dissertations--Epidemiology and Biostatistics

In the United States, the prevalence of long-term exposure to opioid drugs, for both medically and nonmedically indicated purposes, has increased considerably since the mid-1990’s. Concerns have emerged about the potential health effects of opioid use. There is also growing interest in other possible connections with opioid use including cardiovascular disease. Electronic health records (EHR) contain information about patient care in the form of structured codes and unstructured notes. Natural language processing (NLP) provides a tool for processing unstructured textual data in EHR clinical notes and extracts useful information for research with structured formats. The purpose of this dissertation was …

Opioid Use Disorder Treatment With Buprenorphine: Analysis Of Treatment Utilization And Associated Outcomes In Kentucky, Feitong Lei

Theses and Dissertations--Epidemiology and Biostatistics

Opioid use disorder (OUD) is chronic opioid use that results in clinically significant suffering, impairment, or even death. The opioid epidemic in the United States has become a public health and economic crisis, affecting patients' well-being and the nation's overall health and welfare. Eastern Kentucky was among the first regions affected by the opioid crisis, and Kentucky has historically ranked among the top five states for age-adjusted drug overdose mortality rate.

There are three medications (buprenorphine, methadone, naltrexone) approved by the U.S. Food and Drug Administration to treat OUD. As a partial opioid agonist, buprenorphine is a safe medication for …

The Influence Of Distance Learning On Undergraduate Social Work Competency: An Exploratory Study At A Private University, Christine K. Fulmer

Theses and Dissertations--Social Work

This is an exploratory study of undergraduate social work education at a private faith-based university. The university offers both online and residential program options. The purpose of the study was to examine the influence of distance education and program option on the educational outcomes of graduates in a newly developed social work program. The program started in 2015 with its first graduating class in 2017. The sample (N = 262) consists of students graduating in 2017, 2018, and 2019. Students could take classes across program options and each student in the sample completed both traditional and online social work courses. …