Digital Commons Network^™

Opioid Use Disorder Treatment With Buprenorphine: Analysis Of Treatment Utilization And Associated Outcomes In Kentucky, Feitong Lei

Theses and Dissertations--Epidemiology and Biostatistics

Opioid use disorder (OUD) is chronic opioid use that results in clinically significant suffering, impairment, or even death. The opioid epidemic in the United States has become a public health and economic crisis, affecting patients' well-being and the nation's overall health and welfare. Eastern Kentucky was among the first regions affected by the opioid crisis, and Kentucky has historically ranked among the top five states for age-adjusted drug overdose mortality rate.

There are three medications (buprenorphine, methadone, naltrexone) approved by the U.S. Food and Drug Administration to treat OUD. As a partial opioid agonist, buprenorphine is a safe medication for …

The Influence Of Distance Learning On Undergraduate Social Work Competency: An Exploratory Study At A Private University, Christine K. Fulmer

Theses and Dissertations--Social Work

This is an exploratory study of undergraduate social work education at a private faith-based university. The university offers both online and residential program options. The purpose of the study was to examine the influence of distance education and program option on the educational outcomes of graduates in a newly developed social work program. The program started in 2015 with its first graduating class in 2017. The sample (N = 262) consists of students graduating in 2017, 2018, and 2019. Students could take classes across program options and each student in the sample completed both traditional and online social work courses. …

Development Of Univariate And Multivariate Forecasting Models For Methane Gas Emissions In Underground Coal Mines, Juan Diaz

Theses and Dissertations--Mining Engineering

Methane gas management continues to be a challenge concerning underground coal mine safety and productivity worldwide despite the extraordinary effort of the mining industry, governmental agencies, and academia to develop new technologies to monitor and control methane gas emissions more efficiently. The risk of hazardous methane gas concentrations in underground environments cannot be underestimated. Statistical data for the last 100 years indicate that around 80% of the accidents and 90% of the fatalities in the underground coal mining industry in the US were related to methane gas explosions.

Modern underground mine operations monitor and evaluate atmospheric parameters such as barometric …

Laptop Recycling Case Study: Estimating The Contained Value And Value Recovery Process Feasibility Of End-Of-Life Consumer Electronics, Zebulon Hart

Theses and Dissertations--Mining Engineering

Work has been done to establish, through the development and use of novel assay techniques and analysis metrics, the contained value of a sampling of laptop computers (as an analog for myriad e-waste sources). This work has conceptualized e-waste as an alternative to geologic-origin complex metallic ores and has likewise evaluated the feasibility of value recovery from e-waste sources in a similar manner to an ore. The application of conventional and novel mineral separation techniques to e-waste recycling processes has been evaluated and positive results are demonstrated. Further, this work has demonstrated the ability to identify the presence of base …

Development Of Univariate And Multivariate Forecasting Models For Methane Gas Emissions In Underground Coal Mines, Juan Diaz

Theses and Dissertations--Mining Engineering

Methane gas management continues to be a challenge concerning underground coal mine safety and productivity worldwide despite the extraordinary effort of the mining industry, governmental agencies, and academia to develop new technologies to monitor and control methane gas emissions more efficiently. The risk of hazardous methane gas concentrations in underground environments cannot be underestimated. Statistical data for the last 100 years indicate that around 80% of the accidents and 90% of the fatalities in the underground coal mining industry in the US were related to methane gas explosions.

Modern underground mine operations monitor and evaluate atmospheric parameters such as barometric …

Quantitative Methods For Total Lifecycle Risk Likelihood And Impact Assessment In Sustainable Product Design Decision Making, Christian Enyoghasi

Theses and Dissertations--Mechanical and Aerospace Engineering

Sustainable products promise significant economic, environmental, and societal benefits. Numerous methods are available for use during the new product development process to identify alternate product designs that optimize sustainability performance. Once any such design is selected and the product is launched, many uncertainties are likely to affect its performance over the total lifecycle. Such uncertainties give rise to risks that can influence the overall product sustainability performance. However, comprehensive quantitative methods to evaluate the likelihood or the impact of different risks to enable sustainable product design decision making are lacking.

This research aims to address this gap by developing a …

In-Situ Characterization Of Surface Quality In Γ-Tial Aerospace Alloy Machining, David Adeniji

Theses and Dissertations--Mechanical and Aerospace Engineering

The functional performance of critical aerospace components such as low-pressure turbine blades is highly dependent on both the material property and machining induced surface integrity. Many resources have been invested in developing novel metallic, ceramic, and composite materials, such as gamma-titanium aluminide (γ-TiAl), capable of improved product and process performance. However, while γ-TiAl is known for its excellent performance in high-temperature operating environments, it lacks the manufacturing science necessary to process them efficiently under manufacturing-specific thermomechanical regimes. Current finish machining efforts have resulted in poor surface integrity of the machined component with defects such as surface cracks, …

A Decoupled Engineering Methodology For Accurate Prediction Of Ablative Surface Boundary Conditions In Thermal Protection Systems, Justin Cooper

Theses and Dissertations--Mechanical and Aerospace Engineering

The main objective of the present work is to demonstrate a method for prediction of aerothermal environments in the engineering design of hypersonic vehicles as an alternative to the current heritage method. Flat plate and stagnation point boundary layer theory require multiple assumptions to establish the current engineering paradigm. Chief among these assumptions is the similarity between mass and heat transfer. Origins of these assumptions are demonstrated and their relationship to conservative engineering design is analyzed, as well as conditions where they possibly break down. An alternative approach for assessing aerothermal environments from the fluid domain is presented, which permits …

The Effects Of Reference-Command Preview On The Strategies That Humans Use In Command-Following Tasks, Amelia J. S. Sheffler

Theses and Dissertations--Mechanical and Aerospace Engineering

This thesis presents results from an experiment in which 22 human subjects each interact with a dynamic system 40 times over a one-week period. For each interaction, a subject performs a command-following task, where the reference command is the same for all 22 subjects but different on each trial. The subjects are divided into 2 groups of 11 subjects. One group performs the command-following task without reference-command preview. The other group is provided with 1-s preview of the reference command. The experimental results are used to examine the effects of reference-command preview. For the group with 1-s reference-command preview, the …

Numerical And Scaling Study On Application Of Inkjet Technology To Automotive Coating, Masoud Arabghahestani Dr.

Theses and Dissertations--Mechanical and Aerospace Engineering

A thorough literature review identified lack of precision control over quality of droplets generated by the currently available industrial sprayers and a growing need for higher quality droplets in the coating industry. Particularly, lack of knowledge and understanding in continuous inkjets (CIJ) and drop-on-demand (DOD) technologies is identified as significant. Motivated by these needs, this dissertation is dedicated to computational fluid dynamics (CFD) and scaling studies to improve existing inkjet technologies and develop new designs of efficient coating with single and/or multiple piezoelectric sensors to produce on-demand droplets. This dissertation study aims at developing a new DOD type coating technology, …

Formation Control With Collision Avoidance For Fixed-Wing Unmanned Air Vehicles With Speed Constraints, Christopher Heintz

Theses and Dissertations--Mechanical and Aerospace Engineering

Advances in the miniaturization of powerful electronic components and motors, the democratization of global navigation satellite systems (GNSS), and improvements in the performance, safety, and cost in lithium batteries has led to the proliferation of small and relatively inexpensive unmanned aerial vehicles (UAVs). Many of these UAVs are of the multi-rotor design, however, fixed-wing designs are often more efficient than rotary-wing aircraft, leading to a reduction in the power required for a UAV of a given mass to stay airborne. Autonomous cooperation between multiple UAVs would enable them to complete objectives that would be difficult or impossible for a single …

Art Education In Medical Education: Benefits And Challenges, Sara K. Brown

Theses and Dissertations--Art and Visual Studies

Humanity is synergistic with art and medicine. Likewise, art education can be impactful throughout medical education. Art as a tool to develop the next generation of healthcare differs from the clinical goals of creative art therapies. Over the prior decade, many medical schools now provide curricular offerings in the arts and humanities. Less is known about the application in postgraduate medical settings. The focus of this thesis is to review the pairing of artist-educators with postgraduate medical training programs.

One such program is ArtsCAFE (Arts Connect Around Food and Enrichment), an intercollegiate project fusing experienced arts educators with medical educators …

Modeling The Effects Of Adverse Childhood Experiences Using A Mouse Model Of Neglect: Mechanisms Of Adiposity Expansion In Females, Jacqueline Leachman

Theses and Dissertations--Pharmacology and Nutritional Sciences

Adverse childhood experiences (ACEs) are an independent risk factor for chronic disease, including obesity and metabolic syndrome. We have previously shown that a mouse model of early life stress, maternal separation and early weaning (MSEW), exacerbates high-fat diet (HF)-induced obesity only in adult female mice. In agreement, the analysis of several cohorts of participants exposed to ACEs have shown that women are more susceptible to develop obesity than men. Therefore, the aim of this study was to investigate the link between early life stress and obesity in pre-clinical and clinical settings. Male and female MSEW mice fed 1 week a …

Uncovering The Role Of Apoe4 On Alzheimer’S Disease-Related Neuroinflammation, Courtney Marie Kloske

Theses and Dissertations--Physiology

Alzheimer’s disease (AD) is the most common neurodegenerative disease and is characterized by two hallmark pathologies: amyloid-beta plaques (Ab plaques) and hyperphosphorylated, aggregated tau tangles. These pathologies are typically accompanied by the presence of neuroinflammation which is primarily mediated by microglia. Interestingly, several genetic risk factors that increase the risk of AD also have direct impacts on neuroinflammation. Of interest, Apolipoprotein E (ApoE) is the largest genetic risk factor for AD. ApoE has three isoforms- E4 confers an increased risk for AD, E3 is considered the “control” phenotype, and E2 is protective against AD. E4 plays a role in virtually …

Immunoregulatory Receptor Genetics, Expression, And Splicing Studies In Alzheimer’S Disease, Benjamin C. Shaw

Theses and Dissertations--Physiology

Microglia are the resident immune cells of the brain, undertaking many critical tissue maintenance functions such as immune surveillance and phagocytosis. Microglial dysfunction has recently been identified as a multi-stage signature of many neurodegenerative diseases, including late-onset Alzheimer’s Disease (LOAD). Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in over thirty genes that modulate risk of developing LOAD. In the central nervous system, roughly half of these LOAD-associated genes are primarily expressed in microglia. The proteins encoded by these genes include cell surface receptors that contain either immunomodulatory tyrosine-phosphorylated activating motifs (ITAMs) or inhibitory motifs (ITIMs), including TREM2 …

Investigating The Uncertainties In Ct Non-Small Cell Lung Cancer Radiomics, Gary Ge

Theses and Dissertations--Radiation Medicine

Radiomics is a technique that extracts quantitative features, termed radiomic features, from medical images using data-characterization algorithms. These radiomic features can be used to identify tissue characteristics and radiologic phenotyping that are not observable by clinicians in a non-invasive, low-cost manner, potentially generating image biomarkers for clinical decision. To date, there are still many uncertainties involved in radiomics which limit its clinical implementation. Herein, we propose to explore the impact of each component in the radiomics pipeline on predicting clinical outcomes. In Chapter II, we conduct a thorough review of CT lung cancer radiomics studies to examine the typical feature …

Non-Normative Critical Life Events: Where Dyadic Coping And Attachment Meet, Talley Mortara

Theses and Dissertations--Family Sciences

The aim of the current study was to examine both dyadic coping and anxious attachment following the experience of a critical non-normative life event. Pairfam, a nationally representative German sample, was used as a secondary data set for this quantitative study. Paired samples t-tests were used to analyze the data from 559 German couples to track statistically significant increases or decreases in the perception of dyadic coping responses and anxious attachment levels when a non-normative critical life event happened at some point in the previous two years. Results found that the partner of the anchor showed a statistically significant increase …

Nutritional Status In Critical Care Of Covid-19 Patients, Dolph Lewis Davis Iii

Theses and Dissertations--Nutrition and Food Systems

Critical care nutrition is a poorly researched, and such a sudden pandemic event requiring manipulation of nutritional status via propofol-induced sedation for mechanical ventilation is potentially impactful on patient outcomes. This paper seeks to provide context to the impact of critical care protocols on the nutritional status of obese patients suffering from COVID-19.

“It’S Just Part Of Our Hospitality:” Examination Of Cultural Factors That May Inform Future Initiatives To Improve Health Outcomes In A Rural Appalachian Community, Lauren Cassidy Batey

Theses and Dissertations--Nutrition and Food Systems

Diet and physical activity are influenced by a person’s culture and may contribute to the presence of health disparities within a geographic region. Health disparities are evident in Appalachia where a unique cultural identity exists. Culture-based initiatives focused on improving diet quality and increasing physical activity have improved health outcomes in diverse groups, yet interventions considering geographically tied cultures, like Appalachia, are limited. This study aims to identify specific aspects of Appalachian culture that influence health outcomes to inform and increase success of health focused interventions. Five focus groups were conducted in one rural Appalachian community in summer 2021. Grounded …

Farmers’ Market Incentive Program As An Intervention For Improving Behavior Regarding Fruit And Vegetable Consumption In Children And Adolescents, Madison Blades

Theses and Dissertations--Nutrition and Food Systems

Background: Previous research shows that there is low consumption of fruits and vegetables in children and adolescents, specifically those residing in the state of Kentucky which is ranked the lowest of all states in fruit and vegetable (F/V) consumption. The lack of F/V in a diet of someone during their developmental ages can result in negative health outcomes in the future.

Objective: To determine if the use of a farmers’ market incentive program as a nutritional intervention affects the consumption of F/V in children and adolescents.

Methods: 261 children and adolescents, ages 3-14, from 160 families participated in a 10-week …

Family And Consumer Sciences Extension Agents Perception Of A Sustainable Eating Curriculum For Kentuckians, Lindley Barker

Theses and Dissertations--Nutrition and Food Systems

The population is rapidly increasing all over the world. As foods are produced for us to consume, the food system generates negative environmental impacts at each step. The extent of damage generated by food production depends on the amount of land, water, and energy depleted. These environmental impacts can result in reduced quantities of food produced, damages to the land and water used to grow/produce food, pollution of food, and food waste. All of which impact the amount of product produced. Thereby, shifting food-related behaviors of consumers toward sustainable eating may be a way to promote the health of people …

The Effect On Incorporating Fresh Fruits And Vegetables Into An Emergency Food Box Program In Rural Appalachia Kentucky, Zixuan Li

Theses and Dissertations--Nutrition and Food Systems

About 1 in 8 Kentuckians experiencing food insecurity. Low-income Appalachian Kentuckians often utilize food assistance programs and community resources to obtain food and they have lack regular access to fresh food, especially fruits and vegetables. Of concern is nutrition quality and the ability to use food items. The study aimed to explore if and how low-income Appalachian Kentuckians living in a food desert utilized their standard food pantry box as well as a supplemental box of free fresh produce. The study was done through distribution of supplemental fruit and vegetable boxes along with their emergency food box seven different times …

An Examination Of Organic Options In Tomato Systems And Their Use As Alternatives To Copper-Based Products, Erica Ann Fealko

Theses and Dissertations--Plant Pathology

Organic farming is an ever-increasing segment of tomato production. Currently, limited information is available which directly compares conventional to organic treatment programs for disease control in tomato production. Furthermore, many methods available rely on the use of copper products which may be contribute to high Cu levels in agricultural soils. In this study, the efficacies of current conventional and organic methods were compared. In addition, newer disease-control programs, with and without copper were examined, which potentially could reduce over-reliance on copper products.

Standard organic and conventional spray programs were conducted over a four year period targeting two pathogens, Alternaria tomatophila …

The Effect Of Intra-Articular Corticosteroids On The Systemic Messenger Rna Response In An Equine Experimental Inflammation Model, Emma Elaine Partridge

Theses and Dissertations--Veterinary Science

Intra-articular (IA) corticosteroids are regularly used in equine athletes for the control of joint inflammation. The goal of this study was to utilize an acute synovitis inflammation model to determine the residual effects of IA betamethasone and triamcinolone acetonide on various inflammatory parameters and lameness.

Five mixed-breed, 2-year-old horses were randomly allocated to an IA treatment of the radiocarpal joint with 9 mg of either betamethasone or triamcinolone acetonide. Two weeks following treatment, horses were injected with 1μg of lipopolysaccharide (LPS) diluted in 1 mL of 0.9% sterile saline. Following LPS injection, horses were crossed-over and both sets of injections …

The Effects Of Cannabidiol On Senior Equine Health, Shelley Turner

Theses and Dissertations--Veterinary Science

Cannabis sativa L., has been revealed to produce hundreds of phytocannabinoids, of which cannabidiol (CBD) is one of the most desired. It has been revealed that CBD can potentially treat inflammation and act as an analgesic in humans without psychoactive effects of delta-9-tetrahydrocannabinol (THC). Recently, there has been interest in understanding the potential health benefits of CBD for horses. With an increasing senior horse population (< 15 years old), alternatives to the use of non-steroidal anti-inflammatory drugs (NSAIDs) such as phenylbutazone, firocoxib, and flunixin meglumine, are desired as these common anti-inflammatory treatments have negative side effects. Because senior horses may have chronic low-grade inflammation, termed inflamm-aging, they are a natural model to investigate the efficacy of CBD on inflammatory responses as well as other health parameters. Given this interest, and due to the lack of research conducted on CBD in the horse, the overall objective of this dissertation work was to conduct both basic and applied research investigating the effects of CBD on equine immune function and health. The first objective was to determine the in vitro effects of CBD as an anti-inflammatory. Peripheral blood mononuclear cells (PBMCs) from senior horses were cultured in vitro with increasing concentrations of pure CBD dissolved in dimethyl sulfoxide (DMSO). These cells were …

The Microbiome Of The Equine Roundworm, Parascaris Spp., Jennifer Lynn Cain

Theses and Dissertations--Veterinary Science

Parasitic nematodes, including the large roundworms colloquially known as ascarids, affect the health and well-being of livestock animals worldwide. The equine ascarid, Parascaris spp., was the first ascarid parasite to develop wide-spread anthelmintic drug resistance, with other species slowly following suit. There are no new classes of anthelmintics currently in development, and a solution to the ever-increasing prevalence of resistance is desperately needed. The microbiome has been shown to be an important factor in the fitness and health of many organisms and changes to microbiome composition have been associated with a plethora of diseases. The microbiome is also important to …

Spatial Ecology Of Rocky Mountain Elk (Cervus Canadensis Nelsoni) Cows In Southeastern Kentucky, Nathan Dennis Hooven

Theses and Dissertations--Forestry and Natural Resources

The elk (Cervus canadensis) was extirpated from its range in eastern North America by the end of the 1800s, prompting several U.S. states and Canadian provinces to begin translocation programs with the goal of reestablishing elk populations. While eastern elk managers have relied on information from western herds to guide population and habitat management, there is a need for region-specific research on the spatial ecology and habitat associations of translocated elk given the stark differences in landscape, climate, predator communities, and harvest regimes across the continent. While the Kentucky elk reintroduction is one of the best documented programs …

Lignin Valorization Via Reductive Depolymerization Using Promoted Nickel Catalysts And Sub- And Supercritical Methanol, Julia Parker

Theses and Dissertations--Biosystems and Agricultural Engineering

While lignin has been regarded as the most promising renewable feedstock for the sustainable manufacture of aromatic compounds, lignin valorization is necessary to improve the economic viability of biorefineries. Reductive catalytic fractionation (RCF), which combines delignification and lignin depolymerization into a single stage while maintaining the structure and integrity of the cellulose component, has evolved as an effective method for processing biomass. The ability of Cu and Fe to promote the performance of a 20% Ni/alumina catalyst when converting native lignin to alkylphenols by RCF in sub- and supercritical methanol was tested. The effectiveness of lignin extraction as measured by …

Implications To Tap And Stream Water Chemistry Due To Variations In Sampling Locations And Watershed Land Use, Dayana Rodriguez

Theses and Dissertations--Biosystems and Agricultural Engineering

The Kentucky River Basin, which is in the Eastern Kentucky Coal Field region, is a rural region with sparse population distribution and a history of water quality impairments. The long history of mining activity in the Commonwealth has not only left a mark on the area’s economy, but it has also shaped the environment. Changes in land use from forested areas to surface mining have been shown to significantly change water chemistry and hydrology. To date, there is limited information regarding the potential exposure and introduction of heavy metals and sulfate entering rural water treatment plants, resulting in a notable …

Classifying And Mapping Aquatic Vegetation In Heterogeneous Stream Ecosystems Using Visible And Multispectral Uav Imagery, Rozalia Agioutanti

Theses and Dissertations--Biosystems and Agricultural Engineering

The need for assessment and management of aquatic vegetation in stream ecosystems is recognized given the importance in impacting water quality, hydrodynamics, and aquatic biota. However, existing approaches to monitor are laborious and its currently not feasible to track spatial and temporal differences at broad scales. The objective of this study was therefore to map and classify aquatic vegetation of a shallow stream with heterogenous mixtures of emergent and submerged aquatic vegetation. Data was collected in the Camden Creek watershed within the Inner Bluegrass Region of central Kentucky. The use of unmanned aerial vehicles (UAVs) was employed and both visible …