Digital Commons Network^™

Jordan Cofer Named Vice Chancellor For Academic Affairs And Dean, Communications And Marketing

Campus News Archive

No abstract provided.

Fibroblasts And Osteoblasts Behavior After Contact With Different Titanium Surfaces Used As Implant Abutment: An In Vitro Experimental Study, Jose Henrique Cavalcanti De Lima, Patricia Cristina Matos Robbs, Elena Mavropoulos Oliveira Tude, Piedad N. De Aza, Eleani Maria Da Costa, Antonio Scarano, Juan Carlos Prados-Frutos, Gustavo Fernandes, Sergio Alexandre Gehrke

MOSDOH Faculty Publications

Background: The goal of this in vitro study was to compare three different surfaces: two types of implant surfaces commercially available ([a] smooth/machined and [b] acid-treated surface) versus (c) anodized surface. Discs were manufactured with commercially pure titanium (CP) grade IV, which were subsequently analyzed by scanning microscopy and fibroblastic and osteoblastic cell cultures. Methods: Ninety-nine discs (5 × 2 mm) were manufactured in titanium grade IV and received different surface treatments: (i) Mach group: machined; (ii) AA group: double acid etch; and (iii) AN group: anodizing treatment. Three discs from each group were analyzed by Scanning Electron Microscopy (SEM) …

Assessing The Effectiveness Of Non-Traditional Climate Change Communication Tools In The City Of Santa Cruz, Saara Ranabhat

Master's Theses

Coastal cities face significant challenges from climate-induced coastal hazards. The City of Santa Cruz is a medium-sized municipality in Monterey Bay on California's Central Coast with over $1 billion worth of property and infrastructure at risk to climate-induced coastal hazards by 2100. However, city officials have noticed a lack of representation of climate-vulnerable communities in the development of various climate adaptation plans and policies. In order to remedy this problem, the City is experimenting with various climate change communication tools, such as virtual reality (VR), card games, murals, and comic books, in collaboration with different agencies. But limited understanding exists …

Exploring The Link Between Urinary Albumin Excretion And Neutrophil-To-Lymphocyte Ratio In Type 2 Diabetes Mellitus: A Cross-Sectional Study, B Dharani, S Sugantha Priya, Suba A

Digital Journal of Clinical Medicine

Objectives: Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by persistent hyperglycemia resulting from insulin resistance and inadequate insulin production. A critical aspect of T2DM is its microvascular complications, notably diabetic nephropathy, which progresses from microalbuminuria to overt proteinuria, and eventually End-Stage Renal Disease (ESRD). Inflammation-induced endothelial dysfunction is a key factor in the progression of diabetic nephropathy. The neutrophil-to-lymphocyte ratio (NLR) is an easily measurable marker derived from routine leukocyte analysis, reflecting systemic inflammation. Despite the known association between chronic inflammation and diabetic nephropathy, studies exploring this relationship remain limited. This study aims to investigate the correlation …

Tackling The Dual Burden Of Malnutrition In Pregnancy - Pregnancy After Weight Loss Surgery, Kate Maslin, Kathryn Hart, Jill Shawe

School of Nursing and Midwifery

The dual burden of malnutrition is characterised by the coexistence of undernutrition alongside overweight/obesity and diet-related noncommunicable diseases. It is a paradox which disproportionately affects women and is applicable to those who become pregnant after weight loss surgery. Obesity before and during pregnancy is associated with increased risk of adverse perinatal outcomes in both mother and child. Overall lifestyle interventions targeting weight loss in the preconception period have not proven effective, with people, and women in particular, increasingly seeking weight loss surgery. In women with severe obesity, surgery may normalise hormonal abnormalities and improve fertility. In those who become pregnant …

Teaching-Learning Patchwork Technique: Proposed Active Methodology Applied To Doctoral Education, Jonimar Silva Souza, Aloir Pedruzzi Junior, Queila Regina Sousa Matitz, Natália Rese

The Qualitative Report

The didactic-pedagogical innovation at the stricto sensu level can be the differential for a program to train qualified professionals for today's demands. Within this perspective, the study seeks to reflect on the application process and impacts of a teaching strategy based on the Teaching-Learning Patchwork Technique (TLPT) active methodology in a doctoral business administration course. Using duoethnography, the research was carried out with a teacher and two students, generating reflections of different visions about the same object, which provided a greater understanding of the phenomena experienced. The results support that TLPT promotes educational innovation from the promotion of teaching worked …

Transformative Visions Of Qualitative Inquiry: Performative, Philosophical, And Artistic Transformations, Niroj Dahal

The Qualitative Report

I am writing this review, Transformative Visions for Qualitative Inquiry, considering performative, philosophical, and artistic transformations as an essential reading for faculty and students—novice and veteran. It inspires readers, writers, and novice and veteran researchers in various social sciences disciplines and educational landscapes to envision innovative approaches to healing from crises like the COVID-19 pandemic and/or earthquakes. These processes encourage resisting, recovering, connecting, finding joy, and embracing life. Likewise, Transformative Visions for Qualitative Inquiry centers on the concept of transformation and its potential for the future of qualitative research amidst a world grappling with the multifaceted implications of COVID-19, …

A Handy Guide To Qualitative Research In Education, Abd Aziz Ardiansyah

The Qualitative Report

Marilyn Lichman's Qualitative Research in Education: A User’s Guide is a well-written and valuable textbook for new and experienced researchers. Regarding title and content, this textbook focuses more on educational research. Still, it does not rule out the possibility that this book can be used in qualitative research outside education. An exciting thing was the division of phases into three stages: (1) Tradition, theory, and practice; (2) Research planning; and (3) Collect, organize, and communicate. This perfect division allows researchers who have read this book to conduct qualitative research. Readers will also find that the examples used throughout the text …

The Shifting Landscape Of Adolescent Wellness In Boarding Schools: Can Time Spent Off Screens And Outdoors Improve Adolescent Wellbeing?, Kristen H. Peterson

Dartmouth College Master’s Theses

For nearly twenty years I have worked directly with adolescents as an independent school educator. Whether in the classroom, on the field, or in the dorm, I have observed and supported students through their middle and high school experiences. During this time, I have witnessed an alarming shift in adolescent physical, emotional, and social wellbeing. Concurrently, I have observed a dramatic increase in the amount of time students spend using screen-based devices, and a decrease in their time spent outdoors.

Using research to ground my anecdotal accounts in empirical understanding, my thesis examines whether or not screen use might help …

Deepvelo: Deep Learning Extends Rna Velocity To Multi-Lineage Systems With Cell-Specific Kinetics, Jiao Zhang, Michael D Taylor, Bo Wang

Faculty, Staff and Students Publications

Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often violated in complex and heterogeneous single-cell RNA sequencing (scRNA-seq) data. Using a graph convolution network, DeepVelo overcomes these limitations by generalizing RNA velocity to cell populations containing time-dependent kinetics and multiple lineages. DeepVelo infers time-varying cellular rates of transcription, splicing, and degradation, recovers each cell's stage in the differentiation process, and detects functionally relevant driver genes regulating these processes. Application to various developmental and pathogenic processes demonstrates DeepVelo's capacity to study complex differentiation and lineage decision events in heterogeneous scRNA-seq data.

Live Calcium Imaging Of Virus-Infected Human Intestinal Organoid Monolayers Using Genetically Encoded Calcium Indicators, Joseph M Hyser

Faculty, Staff and Students Publications

Calcium signaling is an integral regulator of nearly every tissue. Within the intestinal epithelium, calcium is involved in the regulation of secretory activity, actin dynamics, inflammatory responses, stem cell proliferation, and many other uncharacterized cellular functions. As such, mapping calcium signaling dynamics within the intestinal epithelium can provide insight into homeostatic cellular processes and unveil unique responses to various stimuli. Human intestinal organoids (HIOs) are a high-throughput, human-derived model to study the intestinal epithelium and thus represent a useful system to investigate calcium dynamics. This paper describes a protocol to stably transduce HIOs with genetically encoded calcium indicators (GECIs), perform …

Editorial: Recommendations On Inclusive Language And Transparent Reporting Relating To Diversity Dimensions For The Journal Of Pediatric Psychology And Clinical Practice In Pediatric Psychology, Katelynn E Boerner, E Thomaseo Burton, Diane Chen, Lori E Crosby, Marisa E Hilliard, Anna M Hood, Nicole A Kahhan, Emily Law, Kristin A Long, Meghan E Mcgrady, Rachel E Sweenie, Idia B Thurston, Cecelia Valrie, Yelena P Wu, Christina L Duncan

Faculty, Staff and Students Publications

No abstract provided.

Advancements In Revascularization Strategies For Acute Mesenteric Ischemia: A Comprehensive Review, Takashi Sakamoto, Mahboob Alam, Chayakrit Krittanawong

Faculty, Staff and Students Publications

Even with modern advancements in the management of acute mesenteric ischemia over the past decade, morbidity and mortality remain high, and the best primary treatment modality is still debated amongst interventionalists. Traditionally, interventionalists have favored an open surgical approach but are now trending for endovascular interventions due to apparent reduced mortality and complications. Newer studies suggest hybrid approaches, and intestinal stroke centers may be superior to either strategy alone. This narrative review will explore the natural history of acute mesenteric ischemia with the aim of increasing interventionalist awareness of modern advancements in revascularization strategies for this devastating disease.

Exploring The Role Of Information And Communication Technologies In Allergic Rhinitis In Specialist Centers: Patient Perspectives On Usefulness, Value, And Impact On Healthcare, Ivan Cherrez-Ojeda, Jean Bousquet, Zouina Sarfraz, Azza Sarfraz, Monica Rodriguez Gonzales, Anna Bedbrook, Nelson Rosario, Benjamin Zepeda-Ortega, Guillermo Guidos, Ulbio Alcivar Molina

Department of Paediatrics and Child Health

Introduction: Information and communication technologies (ICTs) improve patient-centered care and are routinely used in Allergic Rhinitis (AR), but patients' preferences and attitudes are unexplored. This study examines AR-related information preferences and ICT use by AR patients.
Methods: A survey-based cross-sectional study was carried out in Ecuador from July to September 2019 in seven centers of reference for allergic disease. Participants were 18 years or older, diagnosed with AR and had access to ICT and the Internet. Descriptive and binomial logistic regressions were performed. A value of less than 0.05 was considered statistically significant.
Results: 217 patients were included. 47% (n …

Full Issue - Engaging The World: Differential Equations Can Influence Public Policies

CODEE Journal

This is the full issue (front matter and all papers) of the Third CODEE Special Issue, with the theme, "Engaging the World: Differential Equations can Influence Public Policies."

Non-Invasive Methods For Monitoring Weasels: Emerging Technologies And Priorities For Future Research, David S. Jachowski, Scott M. Bergeson, Stacy Cotey, Elizabeth Croose, Tim R. Hofmeester, Jenny Macpherson, Et Al.

Michigan Tech Publications

Weasels (genus Mustela and Neogale) are of management concern as declining native species in some regions and invasive species in others. Regardless of the need to conserve or remove weasels, there is increasingly a need to use non-invasive monitoring methods to assess population trends. We conducted a literature review and held the first ever International Weasel Monitoring Symposium to synthesise information on historical and current non-invasive monitoring techniques for weasels. We also explored current limitations, opportunities, and areas of development to guide future research and long-term monitoring. Our literature search revealed that in the past 20 years, camera traps were …

Real-World Evidence Of Epidemiology, Patient Characteristics, And Mortality In People With Drug-Resistant Epilepsy In The United Kingdom, 2011–2021, Rohit Shankar, Xiaocong Li Marston, Vanessa Danielson, Bronwyn Do Rego, Reginald Lasagne, Oliver Williams, Lara Groves

Peninsula Medical School

Background: A third of people with epilepsy are drug resistant. People with drug-resistant epilepsy (DRE) have a higher risk of mortality and physical injuries than those who respond to anti-seizure medication (ASM). This study describes patient characteristics, comorbidities, and mortality in people with DRE in the UK. Methods: The Clinical Practice Research Datalink was utilised to select people with DRE prescribed a third ASM between 1 January 2011 and 31 March 2021. Annual incidence and prevalence of DRE, patient characteristics, comorbidities, and mortality rates were analysed. Subgroup analysis was performed by age, sex, presence of intellectual disabilities and time from …

Hyperstructures In Chemical Hyperstructures Of Redox Reactions With Three And Four Oxidation States, Fakhry Asad Agusfrianto, Sonea Andromeda, Mariam Hariri

All Works

Hyperstructures find numerous applications across various disciplines. One notable application is in chemistry, particularly in the context of chemical reactions. In 2014, Davvaz introduced the concept of bi-hyperstructures, but their application specifically in chemical reactions, has yet to be thoroughly explored in previous studies. Thus, the primary aim of this paper is to examine and analyze the different types of bi-hyperstructures present within chemical hyperstructures. The scope of this study focuses on two types of chemical hyperstructures: redox reactions and reactions in electrochemical cells. Within these chemical hyperstructures, we investigate the possibility of bi-hyperstructures among bi-semihypergroups, bi-hypergroups, bi-H_v-semigroups, and bi-H_v-groups. …

Is Unplanned Excision Of Soft Tissue Sarcomas Associated With Worse Oncological Outcomes?-A Systematic Review And Meta-Analysis, Juan Pretell

All Publications

Background: Soft tissue sarcomas are a group of rare neoplasms which can be mistaken for benign masses and be excised in a non-oncologic fashion (unplanned excision). Whether unplanned excision (UE) is associated with worse outcomes is highly debated due to conflicting evidence.

Methods: We performed a systematic review and meta-analysis following PRISMA guidelines. Main outcomes analyzed were five-year overall survival (OS), five-year local recurrence-free survival (LRFS), amputation rate and plastic reconstruction surgery rate. Risk ratios were used to compare outcomes between patients treated with planned and unplanned excision.

Results: We included 16,946 patients with STS, 6017 (35.5%) with UE. UE …

Exploring The Economics Of Mountain Biking In Keene, New Hampshire: A Gap Analysis, Maddie Smith Nress/Rmp Phd Student, Ethan O'Leary, Dovev Levine, Shannon Rogers Ph.D., Andrew Bohannon

UNH Cooperative Extension

No abstract provided.

Information Services And Academic Integrity, Adaeze Okeke

Library Philosophy and Practice (e-journal)

Globalization and the new trends of information technology introduces us into the era of information explosion/information overload which has left libraries with no option than to be skeptical in regards to its stands on maintaining academic integrity among our present day scholars in their resources handling at the course of their academic ingenuities. On this regard, there's need for strict adherence to the copyright laws in the provisions of Information services. It is on this note that this paper focuses on the core functions of library and information services, the roles of Information services in the protection of intellectual property …

Automated Management Of Time Extension Claims In Construction Projects, Mariam Elazhary

Theses and Dissertations

Disputes within the construction industry have caused parties to incur additional costs not accounted for. In fact, one of the notorious reasons for disputes can be attributed to Extension of Time (EOT) claim submissions. Such is due to its susceptibility to the human factor. Accordingly, there is a need to diminish reliance on the human factor in the EOT process and to bolster it with commodities of the industrial revolution 4.0. While research efforts have endeavored in tackling the drawbacks of the EOT claim process individually, no superior solution is provided to overcome all drawbacks at once. Initially, the literature …

Hsc Connects Newsletter - January 19, 2024, Unm Hsc Communications

HSC Connects Newsletters

Weekly newsletter of the UNM Health Sciences Center.

Comprehensive Workflow And Its Validation For Simulating Diffuse Speckle Statistics For Optical Blood Flow Measurements, Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen-Hao P Lin, Nishighanda Patil, Sumana Chetia, Jason W Trobaugh, Joseph P Culver, Turgut Durduran

2020-Current year OA Pubs

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (

Drug Preparation, Injection-Related Infections, And Harm Reduction Practices Among A National Sample Of Individuals Entering Treatment For Opioid Use Disorder, Laura R Marks, Michael J Durkin, Kelly Ayres, Matthew Ellis

2020-Current year OA Pubs

BACKGROUND: The rise in injection drug use in the USA has led to an increase in injection site infections. We performed a national survey of people who use drugs to evaluate common drug use preparation, harm reduction practices, and experiences with injection site infections.

METHODS: A survey was disseminated to members of the Survey of Key Informants' Patients Program from 2021 to 2022 and distributed to patients 18 years or older newly entering one of 68 substance use disorder treatment programs across the USA with a primary diagnosis of an opioid use disorder. Participants were surveyed about practices when preparing …

Perceived Outcomes Of Periacetabular Osteotomy, Ryan Bialaszewski, John M. Gaddis, Bretton Laboret, Elizabeth Bergman, Edward P. Mulligan, Jenny Lacross, Adina Stewart, Joel Wells

School of Medicine Publications

Aims: Social media is a popular resource for patients seeking medical information and sharing experiences. periacetabular osteotomy (PAO) is the gold-standard treatment for symptomatic acetabular dysplasia with good long-term outcomes. However, little is known regarding the perceived outcomes of PAO on social media. The aims of this study were to describe the perceived outcomes following PAO using three social media platforms: Facebook, Instagram, and X (formerly known as Twitter).

Methods: Facebook, Instagram, and X posts were retrospectively collected from 1 February 2023. Facebook posts were collected from the two most populated interest groups: “periacetabular osteotomy” and “PAO Australia.” Instagram and …

Epstein-Barr Virus-Based Prognostic Model In Nodular Sclerosis Classic Hodgkin Lymphoma, Chen Jiang, Li-Yun Huang, Ji-Hao Zhou, Zhi-Ming Li, Yu Wang, Jian-Chang Fu, Qin Yan, Yu-Yuan Huang, Min Zuo, Shimin Hu, Robert Peter Gale, Yang Liang, Jing-Ping Yun, Yu-Hua Huang

Faculty, Staff and Student Publications

The role of Epstein-Barr virus (EBV) in lymphoma cells of nodular sclerosis classic Hodgkin lymphoma (NScHL) is controversial. Our aim was to explore this and establish a clinically feasible model for risk stratification. We interrogated data from 542 consecutive subjects with NScHL receiving ABVD therapy and demonstrated EBV-infection in their lymphoma cells with EBV-encoded small RNAs (EBERs) in situ hybridization. Subjects were divided into training and validation datasets. As data from the training dataset suggested EBERs-positivity was the only independent prognostic factor for both progression-free survival (PFS) and overall survival (OS), we developed corresponding prognostic models based on it. Our …

Designing Clinical Trials For Patients Who Are Not Average, Thomas E Yankeelov, David A Hormuth, Ernesto A B F Lima, Guillermo Lorenzo, Chengyue Wu, Gaiane M Rauch, Caroline Chung

Faculty, Staff and Student Publications

The heterogeneity inherent in cancer means that even a successful clinical trial merely results in a therapeutic regimen that achieves, on average, a positive result only in a subset of patients. The only way to optimize an intervention for an individual patient is to reframe their treatment as their own, personalized trial. Toward this goal, we formulate a computational framework for performing personalized trials that rely on four mathematical techniques. First, mathematical models that can be calibrated with patient-specific data to make accurate predictions of response. Second, digital twins built on these models capable of simulating the effects of interventions. …

An Incidental Finding Of A High-Grade Glioma With Pleomorphic And Pseudopapillary Features (Hpap) With Pbrm1 Mutation, Maria A Gubbiotti, Jeffrey S Weinberg, Shiao-Pei Weathers, Pushan Dasgupta, Martin C Tom, Martha Quezado, Jason T Huse, Leomar Y Ballester

Faculty, Staff and Student Publications

No abstract provided.

Evaluation Of Potential Biomarkers For Lenvatinib Plus Pembrolizumab Among Patients With Advanced Endometrial Cancer: Results From Study 111/Keynote-146, Vicky Makker, Matthew H Taylor, Carol Aghajanian, Allen L Cohn, Marcia S Brose, Zhu Alexander Cao, Andrey Loboda, Razvan Cristescu, Petar Jelinic, Robert Orlowski, Lea Dutta, Junji Matsui, Corina E Dutcus, Yukinori Minoshima, Mark J Messing

Faculty, Staff and Student Publications

BACKGROUND: Lenvatinib plus pembrolizumab demonstrated clinically meaningful benefit in patients with previously treated advanced endometrial carcinoma in Study 111/KEYNOTE-146 (NCT02501096). In these exploratory analyses from this study, we evaluated the associations between clinical outcomes and gene expression signature scores and descriptively summarized response in biomarker subpopulations defined by tumor mutational burden (TMB) and DNA variants for individual genes of interest.

METHODS: Patients with histologically confirmed metastatic endometrial carcinoma received oral lenvatinib 20 mg once daily plus intravenous pembrolizumab 200 mg every 3 weeks for 35 cycles. Archived formalin-fixed paraffin-embedded tissue was obtained from all patients. T-cell-inflamed gene expression profile (Tcell …