Digital Commons Network^™

Timely Delivery Of Port For Head And Neck Squamous Cell Carcinoma In A County Hospital, Pavan M Jhaveri, Christina H Chapman, Quillan Huang, David J Hernandez

Faculty, Staff and Students Publications

OBJECTIVES: The objective of this study was to compare the rate of post-operative radiation therapy (PORT) initiation within 6 weeks for head and neck squamous cell carcinoma patients treated at a safety net, academic institutio between 2019 and 2021 versus those treated in 2022 after implementation of a new clinical pathway.

METHODS: A retrospective case-control study was performed at a single tertiary care, safety-net, academic institution. Patient demographics, tumor characteristics, dates of surgery, and other treatment dates were collected from the electronic medical record. The time from surgery to PORT was calculated. Patients who started radiation treatment within 42 days …

Anticoagulation With Osocimab In Patients With Kidney Failure Undergoing Hemodialysis: A Randomized Phase 2 Trial, Keith A A Fox, Deepak L Bhatt, Ravi Thadhani, James Hung, Ákos F Pap, Dagmar Kubitza, Wolfgang C Winkelmayer

Faculty, Staff and Students Publications

Individuals with kidney failure undergoing hemodialysis are at elevated risk for thromboembolic events. Factor (F) XI, which is in the intrinsic pathway of coagulation, is emerging as an attractive target for new anticoagulants that may be safer than existing agents. Osocimab-an inhibitory FXIa antibody-is a potential treatment option for such patients. We conducted a phase 2b, double-blind, placebo-controlled trial, in which 704 participants (448 male, 256 female) with kidney failure undergoing hemodialysis were randomized to receive lower- or higher-dose osocimab or placebo. In total, 686 participants (436 male, 250 female) received treatment for ≤18 months (planned minimal treatment period of …

Quaternary Ammonia Compounds In Disinfectant Products: Evaluating The Potential For Promoting Antibiotic Resistance And Disrupting Wastewater Treatment Plant Performance, Zihao Lu, Anna K. Mahony, William A. Arnold, Christopher Marshall, Patrick J. Mcnamara

Civil and Environmental Engineering Faculty Research and Publications

Quaternary ammonium compounds (QACs) are a class of compounds that were widely used as disinfectants during the COVID-19 pandemic and continue to be used as disinfecting agents. After consumer usage, QAC concentrations are diluted in wastewater as they enter wastewater treatment plants. At sub-inhibitory concentrations, QACs may have unintended repercussions, including increased antibiotic resistance and inhibition of process performance in wastewater treatment plants. This review first summarizes how QACs inhibit bacteria and then highlights the mechanisms by which QACs can promote antibiotic resistance in general. Reported environmental concentrations of QACs are compared to concentrations that are suspected to impact antibiotic …

Policy Feedback, Varieties Of Federalism, And The Politics Of Health-Care Funding In The United States, Mexico, And Canada, Daniel Béland, Gregory P. Marchildon, Anahely Medrano, Philip Rocco

Political Science Faculty Research and Publications

Long before the COVID-19 pandemic, health- care spending became a key policy issue across the OECD. Comparing recent institutional trends in public health- care financing in three federal countries—Canada, the United States, and Mexico—this article explores the political struggles over fiscal federalism in health care related to both vertical and horizontal imbalances that can generate regional tensions and pit subnational governments against one an-other and, especially, against the national government. Grounded in a historical institutionalist perspective, the article shows how different institutional legacies shape current conflicts over federal health- care funding in these three highly dissimilar federal countries. Such an …

Novel Hemizygous Single-Nucleotide Duplication In Rpgr In A Patient With Retinal Dystrophy And Sensorineural Hearing Loss, Ryan J German, Blake Vuocolo, Liesbeth Vossaert, Nichole Owen, Richard A Lewis, Lisa Saba, Texome Project, Michael F Wangler, Sandesh Nagamani

Duncan NRI Faculty and Staff Publications

Background: The RPGR gene has been associated with X-linked cone-rod dystrophy. This report describes a variant in RPGR detected with exome sequencing (ES). Genes like RPGR have not always been included in panel-based testing and thus genome-wide tests such as ES may be required for accurate diagnosis.

Methods: The Texome Project is studying the impact of ES in medically underserved patients who are in need of genomic testing to guide diagnosis and medical management. The hypothesis is that ES could uncover diagnoses not made by standard medical care.

Results: A 58-year-old male presented with retinitis pigmentosa, sensorineural hearing loss, and …

Self-Ambivalence: Naming A Contemporary Work–Family Problem That Has No Name, Jenny M. Hoobler, Courtney R. Masterson, Kristie M. Rogers

Management Faculty Research and Publications

As workers and family members, individuals ought to celebrate seemingly positive events (e.g., a promotion and the purchase of a home). Yet, the numerous identities that contemporary workers hold increase the likelihood of an event that is pleasant in one domain being problematic in another and more cognitively and affectively complex than anticipated. We theorize that these events are likely to prompt self-evaluations that are positive (“I'm a success!”) and negative (“I'm a failure.”) across one's identity set, with questions such as “Who have I become?” and “Is this who I ought to be?” The result is self-ambivalence, that is, …

Predicting And Identifying Factors Associated With Undernutrition Among Children Under Five Years In Ghana Using Machine Learning Algorithms, Eric Komla Anku, Henry Ofori Duah

College of Nursing Faculty Research and Publications

Background Undernutrition among children under the age of five is a major public health concern, especially in developing countries. This study aimed to use machine learning (ML) algorithms to predict undernutrition and identify its associated factors. Methods Secondary data analysis of the 2017 Multiple Indicator Cluster Survey (MICS) was performed using R and Python. The main outcomes of interest were undernutrition (stunting: height-for-age (HAZ) < -2 SD; wasting: weight-for-height (WHZ) < -2 SD; and underweight: weight-for-age (WAZ) < -2 SD). Seven ML algorithms were trained and tested: linear discriminant analysis (LDA), logistic model, support vector machine (SVM), random forest (RF), least absolute shrinkage and selection operator (LASSO), ridge regression, and extreme gradient boosting (XGBoost). The ML models were evaluated using the accuracy, confusion matrix, and area under the curve (AUC) receiver operating characteristics (ROC). Results In total, 8564 children were included in the final analysis. The average age of the children was 926 days, and the majority were females. The weighted prevalence rates of stunting, wasting, and underweight were 17%, 7%, and 12%, respectively. The accuracies of all the ML models for wasting were (LDA: 84%; Logistic: 95%; SVM: 92%; RF: 94%; LASSO: 96%; Ridge: 84%, XGBoost: 98%), stunting (LDA: 86%; Logistic: 86%; SVM: 98%; RF: 88%; LASSO: 86%; Ridge: 86%, XGBoost: 98%), and for underweight were (LDA: 90%; Logistic: 92%; SVM: 98%; RF: 89%; LASSO: 92%; Ridge: 88%, XGBoost: 98%). The AUC values of the wasting models were (LDA: 99%; Logistic: 100%; SVM: 72%; RF: 94%; LASSO: 99%; Ridge: 59%, XGBoost: 100%), for stunting were (LDA: 89%; Logistic: 90%; SVM: 100%; RF: 92%; LASSO: 90%; Ridge: 89%, XGBoost: 100%), and for underweight were (LDA: 95%; Logistic: 96%; SVM: 100%; RF: 94%; LASSO: 96%; Ridge: 82%, XGBoost: 82%). Age, weight, length/height, sex, region of residence and ethnicity were important predictors of wasting, stunting and underweight. Conclusion The XGBoost model was the best model for predicting wasting, stunting, and underweight. The findings showed that different ML algorithms could be useful for predicting undernutrition and identifying important predictors for targeted interventions among children under five years in Ghana.

Redefining Value In Nursing Research: Beyond Statistical Significance To Clinical Relevance, Maharaj Singh

College of Nursing Faculty Research and Publications

Background: In quantitative nursing research, a comprehensive reporting of results is crucial. Researchers should not only include traditional statistical significance with p-values but also effect size, confidence interval, observed statistical power, and clinical relevance to provide a more holistic understanding of their findings. Objective: This article addresses key aspects of results reporting in nursing and clinical research. It delves into the importance and interplay of statistical significance, effect size, confidence interval, statistical power, and clinical relevance, and how these elements collectively contribute to a more meaningful interpretation of research outcomes. Method: The article discusses the outcome measures in clinical research, …

The Association Of Hiv-Related Stigma And Psychosocial Factors And Hiv Treatment Outcomes Among People Living With Hiv In The Volta Region Of Ghana: A Mixed-Methods Study, Jerry John Nutor, Akua O. Gyamerah, Henry Ofori Duah, David Ayangba Asakitogum, Rachel G.A. Thompson, Robert Kaba Alhassan, Alison Hamilton

College of Nursing Faculty Research and Publications

Stigma and discrimination have been identified as significant barriers to HIV treatment among people living with HIV (PLWH). HIV stigma affects decision to seek HIV testing and early treatment. Evidence shows that HIV stigma undermines antiretroviral therapy (ART) adherence by affecting the psychological process such as adjusting and coping with social support. In Ghana, stigma toward PLWH occurs in many ways including rejection by their communities and family members, ostracism, and refusal to engage in social interactions such as eating, sharing a bed, or shaking hands. Therefore. we examined PLWH’s experiences with different forms of HIV-related stigma and the impact …

Professionalism In Pre-Licensure Nursing Education: Core Values, Didactic Coursework And Clinical Training, Jessica L. Zemlak, Tamar Rodney, Emma Mangano, Diana-Lyn Baptiste

College of Nursing Faculty Research and Publications

Aim

To discuss professionalism for pre-licensure nursing students and identify recommendations for inclusion in core values, didactic coursework and clinical training.

Background

Professionalism is part of the nursing identity that encompasses integrity and honesty. This concept has been difficult to translate into formal education in nursing programs and clinical practice.

Design

A discursive paper.

Data Sources

A search of national literature without date restrictions in PubMed, CINAHL, Google Scholar and frameworks for nursing education. We explored principles of professionalism in nursing education and practice.

Discussion

Evidence-based literature supports the integration of core values of altruism, autonomy, human dignity, integrity, honesty …

Family Engagement In Paediatric Acute Care Settings: A Realist Review, Teresa Jerofke-Owen, Natalie S. Mcandrew, Joan P. Totka, Karen S. Gralton, Kathleen J. Sawin, Alissa V. Fial, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Aim

To create a programme theory of family engagement in paediatric acute care to explicate the relationships between contexts and mechanisms of family engagement that align with family, direct care providers and healthcare organization outcomes.

Design

Realist review and synthesis.

Data Sources

PubMed, CINAHL, PsycINFO and Web of Science searches for the 2.5-year period (July 2019–December 2021) following our 2021 scoping review.

Review Methods

Following methods described by Pawson and Rycroft-Malone, we defined the scope of the review, searched for and appraised the evidence, extracted and synthesized study findings and developed a supporting narrative of our results.

Results

Of 316 …

Application Of The Adverse Childhood Experiences Framework To The Nicu, Kathryn J. Malin, Dorothy Vittner, Darilek Umber, Kelly Mcglothen-Bell, Allison Crawford, Rebecca Koerner, Britt Frisk Pados, Diana Cartegena, Jacqueline M. Mcgrath, Ashlee J. Vance

College of Nursing Faculty Research and Publications

Background:

Infants and families requiring neonatal intensive care unit (NICU) care often experience significant stress and trauma during the earliest period of the infant's life, leading to increased risks for poorer infant and family outcomes. There is a need for frameworks to guide clinical care and research that account for the complex interactions of generational stress, pain, toxic stress, parental separation, and lifelong health and developmental outcomes for infants and families.

Purpose:

Apply the Adverse Childhood Experiences (ACEs) framework in the context of the NICU as a usable structure to guide clinical practice and research focused on infant neurodevelopment outcomes …

Generation Covid: Coming Of Age Amid The Pandemic., Camelia E. Hostinar, Gabriel M. Velez

College of Education Faculty Research and Publications

No abstract provided.

Activity Space During Treatment With Medication For Opioid Use Disorder: Relationships With Personality, Mood, And Drug Use, Leigh V Panlilio, Albert J Burgess-Hull, Jeffrey D Feldman, Jeffrey M Rogers, Matthew Tyburski, Kirsten E Smith, David H Epstein

Faculty, Staff and Students Publications

Introduction: Activity space in people with substance use disorders (SUDs) has been assessed for theoretical reasons and for detection/prevention of relapse. In this observational study, we relate passively obtained activity space measures to mental states and behaviors relevant to the success of treatment for opioid use disorder. Our long-term goal is to use such data to assess risk in real time and to recognize when SUD patients might benefit from a just-in-time intervention.

Methods: We used GPS data from 238 urban residents in the first 16 weeks of stabilization on medication for opioid use disorder to test preregistered hypotheses about …

Social Determinants Of Health Framework To Identify And Reduce Barriers To Imaging In Marginalized Communities, John E Jordan, Lubdha Shah, Khurram Nasir, Eric M Rohren, Christie M Lincoln

Faculty, Staff and Students Publications

Social determinants of health (SDOH) are conditions influencing individuals' health based on their environment of birth, living, working, and aging. Addressing SDOH is crucial for promoting health equity and reducing health outcome disparities. For conditions such as stroke and cancer screening where imaging is central to diagnosis and management, access to high-quality medical imaging is necessary. This article applies a previously described structural framework characterizing the impact of SDOH on patients who require imaging for their clinical indications. SDOH factors can be broadly categorized into five sectors: economic stability, education access and quality, neighborhood and built environment, social and community …

A Personal And Multicultural Journey Through The World Of Games (With A Little Math) Or Book Review: Around The World In Eighty Games, By Marcus Du Sautoy, Karl-Dieter Crisman

Journal of Humanistic Mathematics

Author and number theorist Marcus Du Sautoy has written a book about games, including a light dose of mathematics. In it, he journeys through far more than (his choice of) eighty of “the world’s greatest games”, laying out a charming voyage through many lands. Despite some reservations, this reviewer finds that Around the World in Eighty Games is well-written and quite fascinating, largely due to its idiosyncratic, personal nature.

The Limits Of Data Science, David E. Drew

Journal of Humanistic Mathematics

Data science can contribute valuable predictions in diverse fields. But I write to express some concerns and red flags. I suggest that data science is being oversold. This article contains three questions that I believe data science must address as this new discipline matures. Is data science significantly different from statistics? This is a question that has haunted the field since the term first was introduced. By creating algorithms based on current societal decision rules that may be biased, even bigoted, does data science lock in and exacerbate inequality? Scholars have identified a continuum from data to information to knowledge …

The Professional Journey Of A Female Mathematician: From India To The United States, Bhamini M. P. Nayar

Journal of Humanistic Mathematics

This article chronicles the journey of an immigrant female mathematician in the United States. The chronicle encompasses early training, encouragements received, road-blocks encountered and the background while growing up which shaped the core of her being. The loving, supportive and educative background she received early in life provided the strength to withstand the hurdles thrown in the path of her career advancement. These hurdles are not unique to the author; many immigrant professionals face similar situations. The purpose of the article is to bring awareness to these challenges such professionals face and how they still persevere with discipline and focus.

Reflections On Teaching Mathematics In Prisons, Matthew Junge

Journal of Humanistic Mathematics

I started teaching math in prison ten years ago during my PhD studies. Since then, I have taught for three different college-in-prison programs across the country. The goal of this piece is to communicate my experiences with the hopes of encouraging more mathematicians to get involved.

The Frankensteinian Nature Of Mathematics, Ali Barahmand

Journal of Humanistic Mathematics

Frankenstein is a story about a scientist who creates a sapient creature that gets out of control and horrifies its creator by its unexpected behavior. In this note, we show that this type of undesirable behavior can reflect a part of the nature of mathematics, and that its origin is related to the ontological question of whether mathematics is invented or discovered. Based on a review of the relationship be- tween discovery and invention, we demonstrate that mathematics has similarities and differences with both discovery and invention. In the natural sciences, new instruments have to be invented to discover new …

Undergraduate Mathematics Students Question And Critique Society Through Mathematical Modeling, Will Tidwell, Amy Bennett

Journal of Humanistic Mathematics

Mathematics can be used as a tool to question and critique society and, in doing so, give us more information about the world around us and how it operates. This however, is not a common perspective that is conveyed to students during their undergraduate mathematics coursework. This paper contributes to the understanding of how undergraduate mathematics students question and critique society via mathematical modeling tasks. In two courses at two universities, 27 mathematics majors and secondary preservice teachers engaged in the modeling process situated in authentic contexts to learn specific concepts and make mathematical connections across domains and disciplines. Both …

Mathematicians Going East, Pasha Zusmanovich

Journal of Humanistic Mathematics

I survey emigration of mathematicians from Europe, before and during WWII, to Russia. The emigration started at the end of 1920s, the time of “Great Break”, and accelerated in 1930s, after the introduction in Germany of the “non-Aryan laws”. Not everyone who wanted to emigrate managed to do so, and most of those who did spent a relatively short time in Russia, being murdered or deported, or fleeing the Russian regime. After 1937, the year of “Great Purge”, only a handful of emigrant mathematicians remained, and even fewer managed to leave a trace in the scientific milieu of their new …

Sharing Four Biscuits Between Three People: An Illustrative Example Of How Mathematics Is Intertwined With Human Values, Lovisa Sumpter, David Sumpter

Journal of Humanistic Mathematics

Despite convincing arguments by mathematicians, philosophers, sociologists and machine learning practitioners to the contrary, there remains a widespread notion amongst many members of the general public (and some practitioners) that mathematics is neutral, that it is free from human values. One reason why this notion persists is that we lack clear-cut examples that demonstrate how mathematics and values are intertwined. In this paper, we offer one such example. In particular, we show that when sharing four biscuits between three people, several possible mathematical and ethical frameworks can be used. We demonstrate that different solutions—hiding one biscuit, arbitrarily sharing the extra …

Finding Your Mathematical Roots: Inclusion And Identity Development In Mathematics, Linda Mcguire

Journal of Humanistic Mathematics

This paper details a semester-long course project that has been successfully adapted for use in mathematics courses ranging from introductory level, general-education classes to advanced courses in the mathematics major. Through creating aspirational mathematical family trees and writing mathematical autobiographies, this assignment is designed to help battle belonging uncertainty, to challenge students to self-situate in relation to the history of mathematical and scientific knowledge, and to make visible a student’s developing identity in mathematics and, more broadly, in STEM.

The construction and scaffolding of the project, assignments, examples of student work, foundational readings, assessment and outcomes, and adaptation strategies for …

Gödel's Theorem In The Continuing Education Of Mathematics Teachers, Ana J. Lemes

Journal of Humanistic Mathematics

The notion of dépaysement épistémologique (epistemological disorientation) aims to capture the sense of disorientation when a learner is led to question their prior assumptions and understandings, generating uncertainty in a context in which they thought they had certain knowledge. This article describes an activity used with a group of practicing mathematics teachers in Uruguay that integrates elements of the history of mathematics related to Gödel’s incompleteness theorem, with the aim of provoking in the participants the experience of dépaysement épistémologique. Results show that several of the teachers participating in the activity felt dépaysement épistémologique, and this feeling triggered …

Front Matter

Journal of Humanistic Mathematics

No abstract provided.

Symposium: Gender, Health, And The Constitution: The New Gender Panic In Sport: Why State Laws Banning Transgender Athletes Are Unconstitutional, Deborah L. Brake

ConLawNOW

This essay considers the role of sport in the new gender panic of legislative activity targeting transgender individuals, which now extends into health and family governance. Sport was one of the first settings—the gateway—to ignite the current culture war on transgender youth. This analysis examines how Title IX of the Education Act of 1972, the popular law responsible for the growth of opportunities for girls and women in sports, has been mobilized in service of a broader gender agenda. Far from providing a persuasive justification for the state laws banning transgender girls from girls’ sports, Title IX, properly understood, supports …

Society To Excavate Site Of Bent's Fort, Rocky Mountain News

Bent’s Old Fort

Colorado State Historical Society's Start for excavation of Fort Bent

Bents Old Fort, La Junta Tribune Democrat

Bent’s Old Fort

Rebuilding of Fort

Arbitrary Government Intrusion Of The Home: Warrantless Pole Camera Home Surveillance Survives Katz But Violates The Fourth Amendment, Hannah J. Eppling

Liberty University Law Review

The Fourth Amendment was adopted with a particular focus—to prevent arbitrary government intrusion. However, today most United States Circuit Courts permit arbitrary government intrusion via warrantless pole camera surveillance because the circuit courts apply the Katz test. As a result, government officials are almost entirely free to decide whether to install pole cameras anywhere on public property to continuously surveille a home for whatever duration the officials decide. Neither probable cause nor application for a warrant are required. The officials then not only surveil all visible home activities through the cameras, but the officials also record the surveillance and may …