Digital Commons Network^™

Optimization Of The Antifungal Properties Of The Bacterial Peptide Entv By Variant Analysis, Shantanu Guha, Shane A Cristy, Giuseppe Buda De Cesare, Melissa R Cruz, Michael C Lorenz, Danielle A Garsin

Faculty, Staff and Student Publications

Fungal resistance to commonly used medicines is a growing public health threat, and there is a dire need to develop new classes of antifungals. We previously described a peptide produced by Enterococcus faecalis, EntV, that restricts Candida albicans to a benign form rather than having direct fungicidal activity. Moreover, we showed that one 12-amino acid (aa) alpha helix of this peptide retained full activity, with partial activity down to the 10aa alpha helix. Using these peptides as a starting point, the current investigation sought to identify the critical features necessary for antifungal activity and to screen for new variants …

Finding And Developing The 21st Century Scientific Pioneer, Brent Roberts, Gregory Feist, Rodica Ioana Damian, Rodrigues Fabretti, Nathan Kuncel, Gregory Crawford, Cosima Crawford, Ernst Fehr

Faculty Research, Scholarly, and Creative Activity

Research on the personality of creative scientists is revisited using the Neo-Socioanalytic model of personality psychology as an organizing framework. Past research shows that creative scientists, largely from the 20th century, were distinguished by high levels of openness to experience, dominance, ambition, intelligence, and low levels of agreeableness. Contradictory findings for environmental influences highlighted the potential importance of both supportive and adverse diversifying experiences. Developmental trends also run contrary to the likelihood of scientific creativity occurring later in life, which is consistent with the life span models of creativity. Based on this review, we highlight much needed updating to the …

Outpatient Administration Of Car T-Cell Therapy: A Focused Review With Recommendations For Implementation In Community Based Centers, Ariel Perez, Tiba Al Sagheer, George Nahas, Yuliya Linhares

All Publications

Chimeric Antigen Receptor T-cell (CAR-T) therapy has transformed the treatment landscape for hematological malignancies, showing high efficacy in patients with relapsed or refractory (R/R) disease and otherwise poor prognosis in the pre-CAR-T era. These therapies have been usually administered in the inpatient setting due to the risk of cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). However, there is a growing interest in the transition to outpatient administration due to multiple reasons. We review available evidence regarding safety and feasibility of outpatient administration of CD19 targeted and BCMA targeted CAR T-cell therapy with an emphasis on the …

2024-05-08 Totally Booked: “The Possibility Of An Island” [Review], Dylan Berman

The Spectator Online

No abstract provided.

Nutrition, Obesity, And Seborrheic Dermatitis: Systematic Review, Emily Woolhiser, Noah Keime, Arya Patel, Isaac Weber, Madeline Adelman, Robert P. Dellavalle

Student Publications

Background:

Pathogenesis of seborrheic dermatitis involves lipid secretion by sebaceous glands, Malassezia colonization, and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity.

Objective:

This study aimed to summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in patients with seborrheic dermatitis and to provide useful insights into areas of further research.

Methods:

A literature search of Scopus, PubMed, …

Bascom V. 1875 Atl. Ave Dev., Llc

All Decisions

In a putative class action seeking damages for rent overcharges, the Landlord, appealed the denial of its motion to dismiss the complaint. The tenant alleged violations of the Rent Stabilization Law and Code, asserting that the landlord improperly inflated registered initial rents. The court affirmed the denial, stating that the allegations, including the manipulation of initial regulated rent, were sufficient to survive dismissal. The decision emphasizes the importance of properly registering rents and interpreting lease terms in light of surrounding circumstances.

Koti V. Vasquez

All Decisions

In this owner's use holdover proceeding, the landlord sought possession of an apartment, alleging immediate and compelling necessity for personal occupancy. However, the court granted the tenant's motion to dismiss, finding the predicate notice insufficient. The notice lacked specificity regarding the landlord's intent and failed to provide factual details supporting the claimed necessity for occupancy. The court emphasized that a notice of termination must include specific allegations relevant to the particular proceeding, not merely statutory language, to sustain an eviction action.

418 W. 130 St. Llc V. Espinal

All Decisions

In this holdover-licensee case, the court dismissed the proceeding after determining that the tenants, despite not being named on the lease, were entitled to succeed to the rent-stabilized tenancy as family members of the prior tenants. The court emphasized the legal right of co-tenants to occupancy independent of each other and the importance of preventing dislocation of long-term residents. The decision underscores the significance of familial relationships and the remedial purpose of succession rights in rent-stabilized housing.

City Of New York V. Elizabeth St., Inc.

All Decisions

In a holdover breach of lease proceeding, the City of New York sought possession of premises leased to Elizabeth Street, Inc. The court ruled in favor of the City, awarding possession of the premises and a money judgment against Elizabeth Street, Inc. The decision was based on the termination of a month-to-month lease and the City's plans to develop the premises for affordable housing. The court granted a stay of eviction for four months, citing the need for salvage and pre-development work.

Liquid-Phase Adsorption Of Dimethyl Methylphosphonate On Poly(Ether Imide) And Its Metal Hydroxide-Integrated Composites, Sukanta K. Mondal, Peter O. Aina, Ali A. Rownaghi, Fateme Rezaei

Chemical and Biochemical Engineering Faculty Research & Creative Works

Understanding the Adsorption Behavior of Dimethyl Methylphosphonate (DMMP), a Key Simulant for Some Nerve Agents, is Crucial for Developing Effective Protective Measures and Ensuring Environmental Safety Against Harmful Chemical Warfare Agents. This Study Systematically Explores the Liquid-Phase Adsorption of DMMP over Branched Poly (Ether Imide) (Ultem) and its Ce (OH)4/Zr (OH)4 Metal Hydroxide Composites. Utilizing UV-Visible (UV-Vis) Spectroscopy, the Adsorption Process Was Monitored over Time to Analyze the Interplay between Various Ultem-Based Composites and DMMP Molecules. Nonreactive Ultem Materials Were Experimentally Identified as Suitable Adsorbents for Liquid-Phase DMMP Capture, Providing a Novel Avenue for Protective Filtration Technologies. It Was Found …

Using Hybrid Machine Learning Models For Stock Price Forecasting And Trading., Ahmed Khalil

Theses and Dissertations

Trading stocks of publicly traded companies in stock markets is a challenging topic since investors are researching what tools can be used to maximize their profits while minimizing risks, which encouraged all researchers to research and test different methods to reach such a goal. As a result, the use of both fundamental analysis and technical analysis started to evolve to support traders in buying and selling stocks. Recently, the focus increased on using Machine learning models to predict stock prices and algorithmic trading as currently there is a huge amount of data that can be processed and used to forecast …

Evaluating Neuroimaging Modalities In The A/T/N Framework: Single And Combined Fdg-Pet And T1-Weighted Mri For Alzheimer’S Diagnosis, Peiwang Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

With the escalating prevalence of dementia, particularly Alzheimer's Disease (AD), the need for early and precise diagnostic techniques is rising. This study delves into the comparative efficacy of Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) and T1-weighted Magnetic Resonance Imaging (MRI) in diagnosing AD, where the integration of multimodal models is becoming a trend. Leveraging data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we employed linear Support Vector Machines (SVM) to assess the diagnostic potential of these modalities, both individually and in combination, within the AD continuum. Our analysis, under the A/T/N framework's 'N' category, reveals that FDG-PET consistently outperforms T1w-MRI across …

Laughing In The Wrong Places: Daniel Clowes And The Danger Of Nostalgia, Liam Cassidy

MFA in Illustration & Visual Culture

This essay explores the relationship between art objects and our past, narrowing in on nostalgia as a malevolent force in American culture that will lead to its eventual downfall. Focusing on Daniel Clowes’ latest graphic novel Monica as a case study, I demonstrate how graphic stories like this seek to reflect rather than interpret, and are often more closely aligned to the creator’s biography than an attempt at broad strokes or political pandering. The essay uses interviews with Clowes at various points of his career, reviews of Monica, academic essays on Clowes, as well as articles and books dissecting …

How Visual Narrative Can Elevate Immigrant Food, Yiting Chai

MFA in Illustration & Visual Culture

Throughout the history of immigration, visual cultural products have provided channels for them to express their voices in North America, helping audiences understand immigrant culture and situations to promote social equality. Photography and cookbooks, as traditional expressions of food art, provide insight into the vitality of food and the way people treat food.

Graphic memoir and social engagement, as emerging categories, have emerged in the post-pandemic period. These diverse creative forms discuss individuals and food deep connections, such as interactions between people and community or a sense of belonging. For immigrant groups, Food is the quintessence of human existence, which …

Toward An Artifact-Forward Feminist Design History, Celeste Caldwell

MFA in Illustration & Visual Culture

Feminist Design History is a field abundantly sown, with lots of room for growth. This essay digs through seminal and contemporary works of feminist design history to learn how to contribute to the field most thoughtfully. I find that future scholarship must meet four criteria in order to effectively meet the goals of feminist design. The proposed research criteria are to cut across definitions of craft and design, challenge the centrality of individuals, draw from a broad pool of resources, and study objects in and outside of the public sphere. I use these criteria to advocate for design research which …

Nostalgic Neighbors: Engaging The Single-Story Of Wholesomeness, Jeffrey Johnson

MFA in Illustration & Visual Culture

In exploring our pasts, memories aren’t made real until they’re articulated out loud. This critical essay offers a meditation on meaning-finding activities of the twentieth century. I offer a definition of the word wholesome, as it exists as both an aesthetic, and as a way to find personal connection with others. As an Illustrator and Storyteller, I carry a responsibility for depicting a way that the world may be remembered. When our stories paint only a picture of a triumphant and moral people we do not only a disservice to the struggles of those same people, but also to the …

Seeing Is Believing: Observing Trans Spirituality Through The Smith-Waite Tarot, Phoebe Santalla

MFA in Illustration & Visual Culture

In 1909 the Rider Company published the Smith-Waite Tarot deck which featured 78 illustrated cards by Pamela Colman Smith. With heavy use of appropriated and ambiguous symbology, the Smith-Waite deck became a meditation tool for realizing alternative realities. By observing the history of the deck, analyzing Smith’s approach to illustration, and retracing the counterculture occult explosion in the 1970s, this essay argues that the Smith-Waite deck is an object the reflects the queered body and self. The modern, trans-contentious, Western political climate creates an environment that obscures the fact that transgender people exist beyond the medicalization of their bodies. To …

Unruly Play In Picture Books, Danielle Groak

MFA in Illustration & Visual Culture

This essay defines unruly and imaginative play based on a variety of interdisciplinary sources. The study examines a selection of children’s picture books that showcase a kind of play that defies normative narrative pacing, power dynamics, and narrative sequence. Future research is recommended to further interdisciplinary discourse on the complexity of imaginative play in children’s literature in a way that honors children’s agency as storytellers.

Ramble: To Wander & Wayfind In Image & Text, Charlotte Fleming

MFA in Illustration & Visual Culture

A pedestrian, an international traveler, and a bored-out-of-his-mind bus commuter take note of their surroundings. What do they notice? What do they find? Why does it matter? With these questions in mind, I take three works as my traveling companions: Robert Weaver’s A Pedestrian View: The Vogelman Diary (2012), Weng Pixin’s “Argentina Diaries” (2020), and Peter Arkle’s Dreaming on the 349 (2023).

This essay places these works in conversation with ideas of space/place (Yi-Fu Tuan), slow looking (Shari Tishman), and mapping artistic practice (Anne West). Ultimately, this essay considers how illustrated works wander through and wayfind meaning in sequences of …

Cover, Uncover: The Changing Face Of Architecture On Locust Street, Cora Trout

MFA in Illustration & Visual Culture

Locust Street was once a vibrant banking and commercial district in downtown St. Louis. Today, it is an untidy collection of new, old, dilapidated, semi-intact, restored, and vacant buildings punctuated by crumbling parking lots and garages threatening imminent collapse. To understand why, we must reassemble Locust Street. As St. Louis watched its wealthy, white population flock to the suburbs at mid-century, the revitalization of the decaying urban center became one of the city’s primary preoccupations. Beginning in the early 1950s, a calculated and conscious physical transformation of the central business district began, lasting through the 1960s. This essay, which integrates …

Goin' Down Swinging: Queer Fury, Mad Green

Graduate School of Art Theses

How can kickboxing uplift a community? How can Queer rage be utilized in community building and artmaking?

As a Queer artist, my work is inspired by my own experiences. Through drawing, printmaking, photography, video, performance, sculpture, and social practice, I dissect my violent upbringing and its lingering threads in my adult life. In this essay, I discuss the two most prominent features of my art practice: Fight and Community. I navigate these ideas through past works, such as a performance piece of me destroying a news article, a short film about institutional homophobia through aliens and immaculate conception, and most …

Spirit, Art, And Care, Jordan Geiger

MFA in Visual Art

In textiles, installations, and interactive performances, I explore how spiritual practice becomes art practice. My experiences as a hospice volunteer, musician, and Buddhist inform my work’s focus on contemplating impermanence as a path to spiritual transformation. Artmaking is a vehicle for exploring the nature of my reality, and both communicating what I find and sharing the path itself. I take inspiration from mystic/artists such as Hilma af Klint, Sengai Gibon, and Agnes Martin, who have sought to expound the path of awakening in artistic form.

In content as well as process, my work explores notions of empathy, awareness, ceremony, and …

Both Sides, Qi Qu

MFA in Illustration & Visual Culture

This essay explores the American’s and the American-born Chinese’s impressions of China and Chinese culture from different perspectives. It mainly focuses on stereotypes, Chinese figures in Hollywood movies, and family dynamics. This essay and data also come from my own research, which involved conducting twenty interviews with my friends, including eight American-born Chinese (all of whom are second-generation immigrants) and twelve American-born individuals (all of them Caucasian, but from various backgrounds). It then focuses on my picture book, BOTH SIDES, representing how the different thinking modes and the specific cultural differences influenced me as a Chinese illustrator working and learning …

Perspectives Of Stress And Coping Among Older, College-Educated African American Women, Jacquelyn Victoria Coats

Brown School Graduate Student Theses and Dissertations

Older African American women have excess rates of stress-associated chronic diseases. Yet, there is limited research exploring the intersectional position of older African American women to identify within-group differences in stress experiences. Specifically, stress and coping among college-educated women in later life has been largely overlooked. As trends show increasing rates of African American women attaining higher education, research investigating stress and coping among this group of high socio-economic status women is a valuable contribution to aging and public health. This study employed constructivist grounded theory methods guided by the Intersectional Life Course Perspective and the Transactional Model of Stress …

Humanizing Affordable Housing: A Public Health Centered Approach To Affordable Housing, Eiman Mohamed

Graduate School of Architecture & Urban Design Theses & Dissertations

This thesis focuses on exploring housing as a determinant of health; thus, the aim is to investigate the historical and current influence of housing design and city planning on occupant health and population health in metropolitan cities. The thesis will primarily examine how housing affects the health of low-income individuals. Historically and presently, this demographic has been disproportionately affected by health issues stemming from overcrowding, substandard housing design, declining neighborhood conditions, and environmental inequities. The goal is to discern the dimensions and standards for healthy housing against which designers and planners can define health outcomes. By acknowledging the factors that …

Microbial Community Composition And Assembly In Diverse Environmental Systems, Rhiannon Celeste Vargas

Arts & Sciences Graduate Student Theses and Dissertations

Analyzing microbial community responses across systems, particularly in coordinated ways, is critical to informing meaningful community ecology patterns. In Chapter 1, I provide historical contexts to the field of microbial community ecology. In Chapter 2 I have investigated a specific opportunistic pathogen, Staphyloccocus pseudintermedius, by utilizing whole genome sequencing to understand the genomic architecture that contributes to the community structures of S. pseudintermedius found in different environmental niches. We found that unlike other Staphylococcal pathogens, S. pseudintermedius niches are indistinguishable by core and accessory gene architecture. Rather, niches are resolved through the encoding of antimicrobial resistances such as those isolates …

Graveyard Shifts: Unearthing Identity Myths And The Retro Rebrand, Rebecca Puno

MFA in Illustration & Visual Culture

This essay examines a trend in brand identity at the time of writing wherein icons of several decades past are resurrected to play to nostalgic feelings associated with a product or service. It begins with a case study of iconography for popular pizza chain logos through several decades alongside definitions of advertising models employed at the time, concluding with the axioms of cultural branding theory. The next section will reexamine the terminology alongside Roland Barthes writing on mythology as a language of semiotics passed through time. The text will then go on to draw parallels between the American fascination with …

Welcome Home Stranger: The Evolution & Assimilation Of The Queer Monster, Dee Cea

MFA in Illustration & Visual Culture

The queer monster has been a staple in fiction for ages. The “other” aspect that defines monstrosity is naturally paired with the ostracized queer figure. How better to accent a demon, than with the demonized? This essay explores why queerness clings to the monstrous, and how this dynamic has shifted over time. When does monstrosity feed into queerness, and when does queerness enhance the monstrous? Using the character Mystique from the long-standing X-Men franchise as a case study, I compare how her strange appearance and abilities have villainized her queer subtext, and yet how they have come to strengthen her …

Cliffhanger, Micah Mickles

MFA in Visual Art

I am Micah Mickles, a mixed-media visual artist in St. Louis, Missouri. My artwork is deeply rooted in my personal experiences and serves as a memorial and monument to counteract the enduring effects of grief and loss. What sets my work apart is the transformative impact of my everyday encounters, inspired by my 14 years of experience working at Trader Joe's. These encounters have led me to reflect on my profound connections with diverse communities. By delving into the hidden narratives of mundane materials encountered in the workplace, I prompt a reexamination of convenience and supply chain origins. Inspired by …

Reactivity Of Adsorbed Trace Metals At Metal (Oxyhydr)Oxide Surfaces As Probed With Isotope Exchange, Greg Ledingham

Arts & Sciences Graduate Student Theses and Dissertations

Metal (oxyhydr)oxide surfaces regulate the accessibility of trace metals in soils and aquatic systems. Up to half of the trace metals in urban environments, river systems, and contaminated soils are associated with mineral surfaces yet this pool often remains bioaccessible. Past studies of adsorption-desorption suggest that macroscopic rates of adsorption at mineral surfaces are likely mass transfer-limited and show biphasic rates, with a fast-adsorbing fraction equilibrating in seconds to minutes and a slower-adsorbing pool binding over a timescale of hours to days. In addition, adsorption-desorption hysteresis has been observed for some metals after aging at metal (oxyhydr)oxide surfaces, indicating that …