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Observing The Personal Narratives Among Conflict Participants And Their Responses To Conflict, Monika Fudala Jan 2023

Observing The Personal Narratives Among Conflict Participants And Their Responses To Conflict, Monika Fudala

Research Papers

No abstract provided.

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Doing A Good Search: Basic Rules And Search Tips, Roy E. Brown Jan 2023

Doing A Good Search: Basic Rules And Search Tips, Roy E. Brown

VCU Libraries Faculty and Staff Publications

This handout is an update of a previous handout and should be used as a reference for those learning how to search databases effectively. The handout covers the basic rules of doing a good search in order to search more efficiently and effectively. The revised handout includes information related to Boolean operators, types of questions, and a list of potential databases to be searched for various clinical questions.

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The Problematics Of Gender For Aviation Emergency Communication During An Inflight Emergency: A Case Study, Angela Cora Garcia Jan 2023

The Problematics Of Gender For Aviation Emergency Communication During An Inflight Emergency: A Case Study, Angela Cora Garcia

Natural & Applied Sciences Faculty Publications

Due to the rarity of female pilots, aviation communication is typically conducted in a single-gender environment. The role of gender in interactions during inflight emergencies has not yet been adequately explored. This single case analysis uses a qualitative approach based on conversation analytic transcripts to investigate how gender may be relevant either explicitly or implicitly in radio trans-missions between flight crew and Air Traffic Control (ATC) personnel, as well as internal ATC phone interactions as participants work to handle an inflight emergency. This incident involved a female pilot and a male copilot, thus providing a naturally occurring rare event to …

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Functional Organization Of Auditory And Reward Systems In Aging, Alexander Belden, Milena Aiello Quinci, Maiya Geddes, Nancy J. Donovan, Suzanne B. Hanser, Psyche Loui Jan 2023

Functional Organization Of Auditory And Reward Systems In Aging, Alexander Belden, Milena Aiello Quinci, Maiya Geddes, Nancy J. Donovan, Suzanne B. Hanser, Psyche Loui

Faculty Works

The intrinsic organization of functional brain networks is known to change with age, and is affected by perceptual input and task conditions. Here, we compare functional activity and connectivity during music listening and rest between younger (n = 24) and older (n = 24) adults, using whole-brain regression, seed-based connectivity, and ROI–ROI connectivity analyses. As expected, activity and connectivity of auditory and reward networks scaled with liking during music listening in both groups. Younger adults show higher within-network connectivity of auditory and reward regions as compared with older adults, both at rest and during music listening, but this agerelated difference …

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A Tale Of Two Rockets: Public History Silence In Alabama, Jerald L. Perlman Jan 2023

A Tale Of Two Rockets: Public History Silence In Alabama, Jerald L. Perlman

History Graduate Student Papers

No abstract provided.

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Law Student’S Educational Experiences And Perceptions Of Legal Abuse, Kylie K. Mckittrick, Julie Olomi Jan 2023

Law Student’S Educational Experiences And Perceptions Of Legal Abuse, Kylie K. Mckittrick, Julie Olomi

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Legal abuse is a form of abuse when an intimate partner uses the court system to further coerce and control their victim. When survivors attempt to keep themselves and their children safe by leaving their abusive partner by using the criminal-legal system, they may be at risk of further abuse, such as legal abuse. More and more research has shown that legal abuse can have severe consequences for survivors such as losing custody of their children, mental health issues like PTSD and depression, costly court cases over the years, and having to stay in contact with their abuser for the …

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Asbury Theological Seminary Academic Catalog : 2023-2024, Asbury Theological Seminary Jan 2023

Asbury Theological Seminary Academic Catalog : 2023-2024, Asbury Theological Seminary

Academic Catalogs

No abstract provided.

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Does Homework Work Or Hurt? A Study On The Effects Of Homework On Mental Health And Academic Performance, Ryan Scheb Jan 2023

Does Homework Work Or Hurt? A Study On The Effects Of Homework On Mental Health And Academic Performance, Ryan Scheb

Journal of Catholic Education

St. Patrick's Catholic School is a coeducational Catholic preparatory school located in a large northeastern city. The school serves an exclusively non-white, working-class student population who demonstrates the motivation and potential to attend and graduate from college. The school’s mission calls for its staff to be guided by cura personalis, meaning they will care for the whole person; yet, data show that the school’s students were extremely stressed out and that much of their stress was attributable to homework. This study sought to determine if reducing the amount of homework could improve students’ mental health while not negatively impacting …

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Experiences Of Learners Who Are Incarcerated With Accessing Educational Opportunities In Ontario, Canada, Ardavan Eizadirad, Tina-Nadia Gopal Chambers Jan 2023

Experiences Of Learners Who Are Incarcerated With Accessing Educational Opportunities In Ontario, Canada, Ardavan Eizadirad, Tina-Nadia Gopal Chambers

Education Faculty Publications

Access to education is a human right that should be upheld for everyone including individuals who are incarcerated as outlined in Article 26 of the United Nations Universal Declaration of Human Rights. 25 interviews were conducted between April to June 2021 with various key stakeholders: 5 staff involved with the delivery of educational programs in jails, 10 learners who are or were formerly incarcerated, and 10 representatives from post-secondary institutions or jails. The objective was to identify barriers limiting access to education, while incarcerated and post-release, and how such barriers can be mitigated. Responses were examined using Critical Race Theory …

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The Use Of Equity-Informed Qualitative Methods In Implementation Science Research To Advance Health Equity: A Scoping Review Of Us-Based Studies, Maryann Deyling Jan 2023

The Use Of Equity-Informed Qualitative Methods In Implementation Science Research To Advance Health Equity: A Scoping Review Of Us-Based Studies, Maryann Deyling

Public Health Theses

Background: Qualitative research methods are central to understanding the complex nuances of implementation of evidence-based interventions and are well-suited to exploring health equity research questions. Scholars have increasingly called for centering equity in implementation science research, but less is known about how qualitative methods have been used for this purpose. This scoping review asks: What equity-informed qualitative methods are used in implementation research focused on health equity? We conceptualize “equity-informed” as encompassing participatory methods and qualitative data collection and analytic methods that explore participants’ unique viewpoints and perspectives on equitable implementation. Methods: This review was carried out in the context …

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Opportunities For Transformation: Equity, Diversity, And Inclusion Across The Developmental Disabilities Network, Lydia Ocasio-Stoutenburg, Jacy Farkas Jan 2023

Opportunities For Transformation: Equity, Diversity, And Inclusion Across The Developmental Disabilities Network, Lydia Ocasio-Stoutenburg, Jacy Farkas

Developmental Disabilities Network Journal

No abstract provided.

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Mapping The Political Shifts And Impacts Of The Climate Movement In The United States, Kevin Rissmiller Jan 2023

Mapping The Political Shifts And Impacts Of The Climate Movement In The United States, Kevin Rissmiller

Government and International Relations Honors Papers

This study explores how organizations within the climate change movement accrue political power and impact federal politics in the United States. It uses twelve semi-structured open-ended interviews with national climate activists at eight organizations to map shifts within the movement. These interviews are paired with additional qualitative analysis of legislative, media, and political rhetoric to evaluate the impact of the movement on American politics. The climate movement’s impacts (establishing the Green New Deal as a legitimate policy vision, shifting the Democratic Party to the left on climate, and the passage of the Inflation Reduction Act) were made possible by a …

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Factors That Predict Weight Loss Success Differ By Diet Intervention Type, Jordan Losavio, Michael J. Keenan, Elizabeth A. Gollub, Heidi J. Silver Jan 2023

Factors That Predict Weight Loss Success Differ By Diet Intervention Type, Jordan Losavio, Michael J. Keenan, Elizabeth A. Gollub, Heidi J. Silver

Faculty Publications

Background: Many types of diet intervention can achieve negative energy balance and successful weight loss in persons with obesity. However, within any dietary strategy, there is large inter-individual variation in the weight loss response. The aim of this study is to determine factors that predict weight loss success for diet interventions that vary by macronutrient and caloric composition. Methods: Participants with BMI 30.0 to 49.9 kg/m2 self-selected one of three diet intervention trials for weight loss: low carbohydrate (LOW CHO), low fat (LOW FAT), or low calorie (LOW KCAL). Multivariable regression models were developed to determine the significance of predictor …

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The Risks And Rewards Of Collegiate Esports: A Multi-Case Study Of Gamers In The United States And Italy, Julie A. Delello, Rochell Mcwhorter, Paul B. Roberts, Tonia De Giuseppe, Felice Corona Jan 2023

The Risks And Rewards Of Collegiate Esports: A Multi-Case Study Of Gamers In The United States And Italy, Julie A. Delello, Rochell Mcwhorter, Paul B. Roberts, Tonia De Giuseppe, Felice Corona

Human Resource Development Faculty Publications and Presentations

As participation in electronic sports (esports) continues to expand globally, colleges and universities are considering how such competitive video gaming might impact recruitment, retention, and the overall student engagement experience. This mixed-methods study focuses on the perceptions of college students in both the United States and Italy regarding the esports phenomenon. A compilation of the research findings from two case studies compared and contrasted themes associated with the benefits and risks to college students participating in esports. The findings highlighted the notion that even during challenging times such as the COVID-19 pandemic, the college students in this study were still …

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“By That Daughter’S Most Devoted Affection”: Anxious And Avoidant Attachments In Opie’S Adeline Mowbray, Meghan E. Hodges Jan 2023

“By That Daughter’S Most Devoted Affection”: Anxious And Avoidant Attachments In Opie’S Adeline Mowbray, Meghan E. Hodges

Comparative Woman

Attachment theory, or the theory that one’s personality and social development is informed greatly by the infant-parent bond, largely arises in the 1950s with the work of John Bowlby. Although the phenomenon was only then beginning to be scientifically evaluated, it has long been observed that the relationship one has with one’s parents is a determinant factor in one’s development. This work investigates the impact of the failure to heal the insecure attachment Amelie Opie’s Adeline Mowbray (1808). Adeline, having grown up in her distant mother’s intellectual shadow, develops a neurotic attachment to her mother which causes romantic maladjustment in …

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Modern-Day Neanderthal Genetic Lifewriting, Interspecies Romance, And The Promise Of Multispecies Autoethnography, Travis Brisini Jan 2023

Modern-Day Neanderthal Genetic Lifewriting, Interspecies Romance, And The Promise Of Multispecies Autoethnography, Travis Brisini

Faculty Publications

Advances in contemporary genetic science have reshaped the narratives whereby individuals and communities make sense of their personal, family, and communal histories. In this process, unknown connections have been revealed and familiar orthodoxies disrupted. This essay examines the consequences of a particularly unusual revelation - the dawning awareness of the presence of nonhuman and archaic human DNA in human genetic lines - for efforts at writing about identity and society. In this autoethnographic account, I examine my own genetic inheritance of Neanderthal DNA, and posit a performative concept of genetic life writing that begins to unpack the complexities of this …

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Preliminary Findings From A Collaborative Storytelling Program On Life Participation And Communication Among Persons With Aphasia, Bijoyaa Mohapatra, Ranjini Mohan Jan 2023

Preliminary Findings From A Collaborative Storytelling Program On Life Participation And Communication Among Persons With Aphasia, Bijoyaa Mohapatra, Ranjini Mohan

Faculty Publications

Aims: The purpose of this study is to evaluate the outcomes of a remotely delivered collaborative storytelling program based on the TimeslipsTM approach in persons with aphasia (PWA). The program aims to improve social interaction, communication, and participation through a guided experience. Methods: Six PWA of mild-moderate severity and of fluent and nonfluent types participated in the program twice a week for seven weeks. They collaboratively created 28 free-form stories from staged pictures. PWA were tested pre- and post-treatment on several validated outcome measures representing each of the Living with Aphasia: Framework for Outcome Measurement (A-FROM) domains. PWA self-rated on …

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Acute Stressors Do Not Impair Short-Term Memory Or Attention In An Aged Mouse Model Of Amyloidosis, Giuliana M. Dimarco, Breanna N. Harris, Alena V. Savonenko, Paul L. Soto Jan 2023

Acute Stressors Do Not Impair Short-Term Memory Or Attention In An Aged Mouse Model Of Amyloidosis, Giuliana M. Dimarco, Breanna N. Harris, Alena V. Savonenko, Paul L. Soto

Faculty Publications

Memory impairment in Alzheimer’s disease patients is thought to be associated with the accumulation of amyloid-beta peptides and tau proteins. However, inconsistent reports of cognitive deficits in pre-clinical studies have raised questions about the link between amyloid-beta and cognitive decline. One possible explanation may be that studies reporting memory deficits often involve behavioral assessments that entail a high stress component. In contrast, in tasks without a high stress component transgenic mice do not consistently show declines in memory. The glucocorticoid cascade hypothesis of aging and the vicious cycle of stress framework suggest that stress exacerbates dementia progression by initiating a …

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Process Scores On Measures Of Learning And Memory: Issue 1, Dustin B. Hammers, Matthew Calamia Jan 2023

Process Scores On Measures Of Learning And Memory: Issue 1, Dustin B. Hammers, Matthew Calamia

Faculty Publications

No abstract provided.

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Process Scores On Measures Of Learning And Memory: Issue 2, Matthew Calamia, Dustin B. Hammers Jan 2023

Process Scores On Measures Of Learning And Memory: Issue 2, Matthew Calamia, Dustin B. Hammers

Faculty Publications

No abstract provided.

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Remote Assessment Of Negative Symptoms Of Schizophrenia, David G. Daniel, Alex S. Cohen, Dawn Velligan, Phillip D. Harvey, Larry Alphs, Michael Davidson, William Potter, Alan Kott, Nina Schooler, Christopher R. Brodie, Raeanne C. Moore, Pierre Lindenmeyer, Stephen R. Marder Jan 2023

Remote Assessment Of Negative Symptoms Of Schizophrenia, David G. Daniel, Alex S. Cohen, Dawn Velligan, Phillip D. Harvey, Larry Alphs, Michael Davidson, William Potter, Alan Kott, Nina Schooler, Christopher R. Brodie, Raeanne C. Moore, Pierre Lindenmeyer, Stephen R. Marder

Faculty Publications

In contrast to the validated scales for face-to-face assessment of negative symptoms, no widely accepted tools currently exist for remote monitoring of negative symptoms. Remote assessment of negative symptoms can be broadly divided into 3 categories: (1) remote administration of an existing negative-symptom scale by a clinician, in real time, using videoconference technology to communicate with the patient; (2) direct inference of negative symptoms through detection and analysis of the patient's voice, appearance, or activity by way of the patient's smartphone or other device; and (3) ecological momentary assessment, in which the patient self-reports their condition upon receipt of periodic …

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Guest Editor’S Introduction: The Need For A Broader, More Inclusive Approach To Child And Adolescent Suicide Prevention, Ryan M. Hill Jan 2023

Guest Editor’S Introduction: The Need For A Broader, More Inclusive Approach To Child And Adolescent Suicide Prevention, Ryan M. Hill

Faculty Publications

No abstract provided.

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The Effects Of Internet-Based Cognitive Behavioral Therapy For Suicidal Ideation Or Behaviors On Depression, Anxiety, And Hopelessness In Individuals With Suicidal Ideation: Systematic Review And Meta-Analysis Of Individual Participant Data, Lasse B. Sander, Marie Beisemann, Philipp Doebler, Hannah Moon Micklitz, Ad Kerkhof, Pim Cuijpers, Philip Batterham, Alison Calear, Helen Christensen, Eva De Jaegere, Matthias Domhardt, Annette Erlangsen, Ozlem Eylem-Van Bergeijk, Ryan Hill, Charlotte Mühlmann, Marie Österle, Jeremy Pettit, Gwendolyn Portzky, Lena Steubl, Bregje Van Spijker, Joseph Tighe, Aliza Werner-Seidler, Rebekka Büscher Jan 2023

The Effects Of Internet-Based Cognitive Behavioral Therapy For Suicidal Ideation Or Behaviors On Depression, Anxiety, And Hopelessness In Individuals With Suicidal Ideation: Systematic Review And Meta-Analysis Of Individual Participant Data, Lasse B. Sander, Marie Beisemann, Philipp Doebler, Hannah Moon Micklitz, Ad Kerkhof, Pim Cuijpers, Philip Batterham, Alison Calear, Helen Christensen, Eva De Jaegere, Matthias Domhardt, Annette Erlangsen, Ozlem Eylem-Van Bergeijk, Ryan Hill, Charlotte Mühlmann, Marie Österle, Jeremy Pettit, Gwendolyn Portzky, Lena Steubl, Bregje Van Spijker, Joseph Tighe, Aliza Werner-Seidler, Rebekka Büscher

Faculty Publications

Background: Suicide is a global public health problem. Digital interventions are considered a low-threshold treatment option for people with suicidal ideation or behaviors. Internet-based cognitive behavioral therapy (iCBT) targeting suicidal ideation has demonstrated effectiveness in reducing suicidal ideation. However, suicidal ideation often is related to additional mental health problems, which should be addressed for optimal care. Yet, the effects of iCBT on related symptoms, such as depression, anxiety, and hopelessness, remain unclear. Objective: We aimed to analyze whether digital interventions targeting suicidal ideation had an effect on related mental health symptoms (depression, anxiety, and hopelessness). Methods: We systematically searched CENTRAL, …

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Effects Of Episodic Food Insecurity On Psychological And Physiological Responses In African American Women With Obesity (Responses): Protocol For A Longitudinal Observational Cohort Study, Candice A. Myers, Robbie A. Beyl, Daniel S. Hsia, Melissa N. Harris, Isabella J. Reed, Danielle D. Eliser, Lauren Bagneris, John W. Apolzan Jan 2023

Effects Of Episodic Food Insecurity On Psychological And Physiological Responses In African American Women With Obesity (Responses): Protocol For A Longitudinal Observational Cohort Study, Candice A. Myers, Robbie A. Beyl, Daniel S. Hsia, Melissa N. Harris, Isabella J. Reed, Danielle D. Eliser, Lauren Bagneris, John W. Apolzan

Clinical Research Faculty Publications

Background: Food insecurity is a risk factor for multiple chronic diseases, including obesity. Importantly, both food insecurity and obesity are more prevalent in African American women than in other groups. Furthermore, food insecurity is considered a cyclic phenomenon, with episodes of food adequacy (ie, enough food to eat) and food shortage (ie, not enough food to eat). More research is needed to better understand why food insecurity is linked to obesity, including acknowledging the episodic nature of food insecurity as a stressor and identifying underlying mechanisms. Objective: The objective of this study is to investigate the episodic nature of food …

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Editorial: Stress-Induced Weight Changes, Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello Jan 2023

Editorial: Stress-Induced Weight Changes, Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello

Clinical Research Faculty Publications

No abstract provided.

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Core Issues, Case Studies, And The Need For Expanded Legacy African American Genomics, Fatimah Jackson, Carter Clinton, Jennifer Caldwell Jan 2023

Core Issues, Case Studies, And The Need For Expanded Legacy African American Genomics, Fatimah Jackson, Carter Clinton, Jennifer Caldwell

Population and Public Health Science Faculty Publications

Introduction: Genomic studies of Legacy African Americans have a tangled and convoluted history in western science. In this review paper, core issues affecting African American genomic studies are addressed and two case studies, the New York African Burial Ground and the Gullah Geechee peoples, are presented to highlight the current status of genomic research among Africa Americans. Methods: To investigate our target population’s core issues, a metadatabase derived from 22 publicly accessible databases were reviewed, evaluated, and synthesized to identify the core bioethical issues prevalent during the centuries of the African American presence in North America. The sequence of metadatabase …

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Comparison Of Selected Exercise Training Modalities In The Management Of Pcos: A Systematic Review And Meta-Analysis To Inform Evidence-Based Guidelines, Giorgia E. Colombo, Xela Dafauce Bouzo, Rhiannon K. Patten, Aya Mousa, Chau Thien Tay, Loyal Pattuwage, Helena J. Teede, Leanne M. Redman, Angelica Lindén Hirschberg, Angelo Sabag Jan 2023

Comparison Of Selected Exercise Training Modalities In The Management Of Pcos: A Systematic Review And Meta-Analysis To Inform Evidence-Based Guidelines, Giorgia E. Colombo, Xela Dafauce Bouzo, Rhiannon K. Patten, Aya Mousa, Chau Thien Tay, Loyal Pattuwage, Helena J. Teede, Leanne M. Redman, Angelica Lindén Hirschberg, Angelo Sabag

Clinical Research Faculty Publications

Background: Polycystic ovary syndrome (PCOS) is a common endocrine condition in women of reproductive age that often presents with reproductive, metabolic, and psychological symptoms. While exercise is part of the management of PCOS, it is unclear which form of exercise may be most effective and for which outcomes. Aim: In order to inform the updated 2023 International evidence-based guideline for the assessment and management of polycystic ovary syndrome, this systematic review aimed to determine the exercise modality that provides the greatest improvement in anthropometric, metabolic, hormonal/reproductive, and psychological outcomes in adult women with PCOS. Methods: Five databases were searched from …

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Race And Sex Differences In The Association Between Lifespan Glycemic Status And Midlife Cognitive Function: The Bogalusa Heart Study, Kathryn L. Gwizdala, Lydia A. Bazzano, Robert L. Newton, Owen T. Carmichael Jan 2023

Race And Sex Differences In The Association Between Lifespan Glycemic Status And Midlife Cognitive Function: The Bogalusa Heart Study, Kathryn L. Gwizdala, Lydia A. Bazzano, Robert L. Newton, Owen T. Carmichael

Clinical Research Faculty Publications

Introduction: Glycemic markers throughout life are associated with increased risk of midlife cognitive decline, yet it is unclear whether these associations differ by race and sex. Methods: This study used cross-sectional analysis of prospectively maintained cohort. 1,295 participants in the Bogalusa Heart Study, a biracial epidemiological cohort located in a micropolitan area core setting, provided fasting plasma insulin (FPI) and glucose (FPG) biannually from 1973 to 2016. Memory, executive function (EF), attention, working memory (WM), and global cognition (GC), collected 2013–2016. Glycemic markers (i.e., FPG, FPI, and HOMA-IR) averaged within lifespan epochs (≤ 20 years, childhood/adolescence (C/A); 21–40 years, early …

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Midlife Neuropsychological Profiles And Associated Vascular Risk: The Bogalusa Heart Study, Ileana De Anda-Duran, Vijaya B. Kolachalama, Owen T. Carmichael, Phillip H. Hwang, Camilo Fernandez, Rhoda Au, Lydia A. Bazzano, David J. Libon Jan 2023

Midlife Neuropsychological Profiles And Associated Vascular Risk: The Bogalusa Heart Study, Ileana De Anda-Duran, Vijaya B. Kolachalama, Owen T. Carmichael, Phillip H. Hwang, Camilo Fernandez, Rhoda Au, Lydia A. Bazzano, David J. Libon

Clinical Research Faculty Publications

Background: Individuals with Alzheimer's disease (AD) often present with coexisting vascular pathology that is expressed to different degrees and can lead to clinical heterogeneity. Objective: To examine the utility of unsupervised statistical clustering approaches in identifying neuropsychological (NP) test performance subtypes that closely correlate with carotid intima-media thickness (cIMT) in midlife. Methods: A hierarchical agglomerative and k-means clustering analysis based on NP scores (standardized for age, sex, and race) was conducted among 1,203 participants (age 48±5.3 years) from the Bogalusa Heart Study. Regression models assessed the association between cIMT ≥50th percentile and NP profiles, and global cognitive score (GCS) tertiles …

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A Data-Driven Examination Of Apathy And Depressive Symptoms In Dementia With Independent Replication, Miguel Vasconcelos Da Silva, Gerardo Javier Melendez-Torres, Zahinoor Ismail, Ingelin Testad, Clive Ballard, Byron Creese, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Jan 2023

A Data-Driven Examination Of Apathy And Depressive Symptoms In Dementia With Independent Replication, Miguel Vasconcelos Da Silva, Gerardo Javier Melendez-Torres, Zahinoor Ismail, Ingelin Testad, Clive Ballard, Byron Creese, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Apathy is one of the most common neuropsychiatric symptoms (NPS) and is associated with poor clinical outcomes. Research that helps define the apathy phenotype is urgently needed, particularly for clinical and biomarker studies. We used latent class analysis (LCA) with two independent cohorts to understand how apathy and depression symptoms co-occur statistically. We further explored the relationship between latent class membership, demographics, and the presence of other NPS. The LCA identified a four-class solution (no symptoms, apathy, depression, and combined apathy/depression), reproducible over both cohorts, providing robust support for an apathy syndrome distinct from depression and confirming that an apathy/depression …

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