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Toward Reliable Symptom Coding In Electronic Health Records For Symptom Assessment And Research: Identification And Categorization Of International Classification Of Diseases, Ninth Revision, Clinical Modification Symptom Codes, Tru Cao, Veronica Brady, Meagan Whisenant, Xueying Wang, Yuxuan Gu, Hulin Wu Sep 2024

Toward Reliable Symptom Coding In Electronic Health Records For Symptom Assessment And Research: Identification And Categorization Of International Classification Of Diseases, Ninth Revision, Clinical Modification Symptom Codes, Tru Cao, Veronica Brady, Meagan Whisenant, Xueying Wang, Yuxuan Gu, Hulin Wu

Faculty, Staff and Student Publications

To date, symptom documentation has mostly relied on clinical notes in electronic health records or patient-reported outcomes using disease-specific symptom inventories. To provide a common and precise language for symptom recording, assessment, and research, a comprehensive list of symptom codes is needed. The International Classification of Diseases, Ninth Revision or its clinical modification ( International Classification of Diseases, Ninth Revision, Clinical Modification ) has a range of codes designated for symptoms, but it does not contain codes for all possible symptoms, and not all codes in that range are symptom related. This study aimed to identify and categorize the first …


Forage News [2024-09], University Of Kentucky Sep 2024

Forage News [2024-09], University Of Kentucky

Forage News

No abstract provided.


A Local Option: How Medicare Patients In Rural States Could Obtain Coverage For Weight Loss Medications, Emily Blackburn Sep 2024

A Local Option: How Medicare Patients In Rural States Could Obtain Coverage For Weight Loss Medications, Emily Blackburn

West Virginia Law Review

There are currently three options when it comes to managing obesity: (1) making nutritional and activity changes; (2) weight loss medications; and (3) weight loss surgery. The existing limited options for managing obesity are even more restricted for Medicare patients. Making lifestyle changes might not be effective for a variety of reasons, including persistent food cravings and experiences of weight stigma from healthcare providers. To qualify for weight loss surgery, Medicare patients must satisfy several criteria in addition to the already specific weight loss surgery requirements. Additionally, weight loss surgery might not be the most viable option for the Medicare …


Environmental Contributions To Cognitive Development: The Role Of Cognitive Stimulation, Divyangana Rakesh, Katie A. Mclaughlin, Margaret Sheridan, Kathryn L. Humphreys, Maya L. Rosen Sep 2024

Environmental Contributions To Cognitive Development: The Role Of Cognitive Stimulation, Divyangana Rakesh, Katie A. Mclaughlin, Margaret Sheridan, Kathryn L. Humphreys, Maya L. Rosen

Neuroscience: Faculty Publications

Early environmental experiences influence children's cognitive and neural development. In particular, cognitive stimulation, defined as environmental inputs that engage the senses and provide learning opportunities for children, fosters acquisition of knowledge across various cognitive domains. Low levels of cognitive stimulation in early life may restrict learning opportunities, contributing to lasting consequences for neural development and later academic and occupational achievement. This review delves into the role of cognitive stimulation in neural development and related cognitive performance, available tools for measuring cognitive stimulation in various settings, and offers insights into future research directions. In addition, variability in cognitive stimulation, often linked …


Windmill Grass And Its Management, Department Of Primary Industries And Regional Development, Western Australia Sep 2024

Windmill Grass And Its Management, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Windmill grass is a native species and the tenth most common summer weed species in the Western Australian (WA) grainbelt. It hosts pests and diseases and utilises stored soil moisture that would otherwise be available to the following crop.


Yellow Spot And Septoria Nodorum Blotch And Their Management In Wheat, Department Of Primary Industries And Regional Development, Western Australia Sep 2024

Yellow Spot And Septoria Nodorum Blotch And Their Management In Wheat, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Leaf spot diseases affecting wheat in Western Australia (WA) are yellow spot (Pyrenophora tritici-repentis), septoria nodorum blotch (Parastagonospora nodorum), and septoria tritici blotch (Zymoseptoria tritici). They are caused by 3 different fungal pathogens but the disease symptoms and biologies are similar.

Impact from leaf spot diseases vary greatly from season to season and between locations. They are a problem in continuous wheat crops in stubble retention (no-till) farming systems. For the most effective control, an integrated disease management (IDM) approach is required.

This page outlines the symptoms, diseases spread and risk factors, yield and quality losses, and management options for …


Pasture Data Reconciliation Of The South West Agricultural Zone Of Western Australia September 2024, Tafesse Estifanos, Amir Abadi Ghadim, Paul Mattingley, Kate Pritchett, Tony Della Bosca Sep 2024

Pasture Data Reconciliation Of The South West Agricultural Zone Of Western Australia September 2024, Tafesse Estifanos, Amir Abadi Ghadim, Paul Mattingley, Kate Pritchett, Tony Della Bosca

Animal production and livestock published reports

Western Australia’s (WA) agricultural land use system features extensive pasture land vital for grazing sheep and cattle. Most pastures in the south west of Western Australia consist of annual species that grow during the cool, wet winters of the Mediterranean climate and senesce in the warm to hot, dry summers. Understanding the spatial distribution of pasture areas within the context of mixed farming is essential for developing effective land management strategies to enhance livestock production and profitability through balanced pasture supply and demand.

This report focuses on reconciling pasture area data for the south-west of Western Australia’s agricultural zone across …


Septoria Avenae Blotch And Its Management In Oats, Department Of Primary Industries And Regional Development, Western Australia Sep 2024

Septoria Avenae Blotch And Its Management In Oats, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Septoria avenae blotch (Phaeosphaeria avenaria f.sp. avenaria) is a stubble borne fungal disease of oats and is the most common oat disease in Western Australia and occurs throughout the cereal growing areas.It is host specific, meaning it only affects oats.

This page summarises the symptoms, factors favouring disease risk and spread, yield and quality losses, and management strategies for the disease


Breeding Ewes Are Worth Feeding, Department Of Primary Industries And Regional Development, Western Australia Sep 2024

Breeding Ewes Are Worth Feeding, Department Of Primary Industries And Regional Development, Western Australia

Animal production and livestock factsheets

Despite potentially elevated grain prices, strong prices for meat and wool mean that Western Australian sheep farmers can confidently supplementary feed their underweight ewes in summer/autumn.

Analysis in 2019, based on then-current prices, showed it was a profitable investment to feed all ewes to maintain condition during pregnancy, and to feed low condition score single bearing ewes and low and medium condition score twin bearing ewes to gain condition.

In 2019, John Young from Farming Systems Analysis Service completed an analysis on the value of a ewe in the WA farming system. His report had some important messages for the …


Evaluating Efficacy Of Vedolizumab, Ustekinumab, And Golimumab In The Management Of Inflammatory Bowel Disease And The Combined Role Of Nutritional Therapy With Biologics: A Review, Shahed Kamal, Karan Varshney, Danielle Josefa F. Uayan, Fides Myles C. Caliwag Sep 2024

Evaluating Efficacy Of Vedolizumab, Ustekinumab, And Golimumab In The Management Of Inflammatory Bowel Disease And The Combined Role Of Nutritional Therapy With Biologics: A Review, Shahed Kamal, Karan Varshney, Danielle Josefa F. Uayan, Fides Myles C. Caliwag

Ateneo School of Medicine and Public Health Publications

Inflammatory bowel disease (IBD), which encompasses both ulcerative colitis (UC) and Crohn’s disease (CD), is a major health burden worldwide. There are increasing concerns surrounding the impacts of this disease due to significant rises in the prevalence rates of IBD across the world. In consideration of the complexities of managing IBD along with this marked rise in prevalence and incidence, developing new forms of treatment for this condition has become a major priority. In recent years, a potential new form of treatment for IBD has emerged in the form of biologic therapies. While there is a high level of optimism …


The Power To Shape The “Political”, Amanda Shanor Sep 2024

The Power To Shape The “Political”, Amanda Shanor

The University of Chicago Business Law Review

The role of corporations in American life has become the focus of intense public and scholarly debate. How do corporations influence political outcomes? What norms or laws should structure corporate political participation? And who should decide what political interventions corporations make? These are vitally important questions that bear on how to deal with the pressing challenges of social media, money in politics, polarization, autocratic threats, and the influence of consolidated capital on governmental and democratic decision-making.

Most conversations about the role of corporations in politics, however, assume a definition of “political.” This key term is commonly taken for granted or …


Neurological Symptoms And Cause Of Death Among Young Children In Low- And Middle-Income Countries, Sara Ajanovic, Zachary Madewell, Shams El Arifeen, Emily Gurley, Mohammad Zahid Hossain, Kazi Munisul Islam, Afruna Rahman, Nega Assefa, Lola Madrid, R Gunturu Sep 2024

Neurological Symptoms And Cause Of Death Among Young Children In Low- And Middle-Income Countries, Sara Ajanovic, Zachary Madewell, Shams El Arifeen, Emily Gurley, Mohammad Zahid Hossain, Kazi Munisul Islam, Afruna Rahman, Nega Assefa, Lola Madrid, R Gunturu

Pathology, East Africa

Importance: The emergence of acute neurological symptoms in children necessitates immediate intervention. Although low- and middle-income countries (LMICs) bear the highest burden of neurological diseases, there is a scarcity of diagnostic and therapeutic resources. Therefore, current understanding of the etiology of neurological emergencies in LMICs relies mainly on clinical diagnoses and verbal autopsies.

Objective: To characterize the association of premortem neurological symptoms and their management with postmortem-confirmed cause of death among children aged younger than 5 years in LMICs and to identify current gaps and improve strategies to enhance child survival.

Design, Setting, and Participants: This cross-sectional …


Physical Decline Rates: Men Versus Women, Ray C. Fair Sep 2024

Physical Decline Rates: Men Versus Women, Ray C. Fair

Cowles Foundation Discussion Papers

This paper uses world records by age in running, swimming, and rowing to estimate a biological frontier of decline rates for both men and women. Decline rates are assumed to be linear in percent terms up to a certain age and then quadratic after that, where the transition age is estimated. The use of world records avoids the possible problem of survivor bias in a sample. The decline rates are smallest for rowing, followed by swimming and then running. Decline rates for women are roughly the same as those for men for the swimming events. They are slightly larger for …


Closing The Gap Between Evidence And Practice For Childhood Obesity Treatment, Alyssa M. Button, Amanda E. Staiano, Hilary K. Seligman Sep 2024

Closing The Gap Between Evidence And Practice For Childhood Obesity Treatment, Alyssa M. Button, Amanda E. Staiano, Hilary K. Seligman

Population and Public Health Science Faculty Publications

No abstract provided.


Remembering My Grandmother: Rev. Maggie T. Mosley (Summer 2024), Cassandra Hawkins Sep 2024

Remembering My Grandmother: Rev. Maggie T. Mosley (Summer 2024), Cassandra Hawkins

Staff Residencies

Dr. Cassandra Hawkins, Associate Director of Data and Quality Management at the Institute of Child Nutrition, pursued a film photography project that invoked a sense of family and introspection about the past and the present.


Energetics Of A World-Tour Female Road Cyclist During A Multistage Race (Tour De France Femmes), Jose L. Areta, Emily Meehan, Georgie Howe, Leanne M. Redman Sep 2024

Energetics Of A World-Tour Female Road Cyclist During A Multistage Race (Tour De France Femmes), Jose L. Areta, Emily Meehan, Georgie Howe, Leanne M. Redman

Clinical Research Faculty Publications

Despite the increased popularity of female elite road cycling, research to inform the fueling requirements of these endurance athletes is lacking. In this case study, we report for the first time the energetics of a female world-tour cyclist competing in the 2023 Tour de France Femmes, an 8-day race of the Union Cycliste Internationale. The 29-year-old athlete presented with oligomenorrhea and low T3 before the race. Total daily energy expenditure assessed with the doubly labeled water technique was 7,572 kcal/day (∼4.3 physical activity levels), among the highest reported in the literature to date for a female. Crank-based mean maximal power …


Determining Diabetic Kidney Disease Severity Using Traditional Chinese Medicine Syndrome Classification, Amanda Yun Rui Lam, Huang Fang Zheng, Kok Keong Teo, Xiao Hui Xin, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Hong Chang Tan Sep 2024

Determining Diabetic Kidney Disease Severity Using Traditional Chinese Medicine Syndrome Classification, Amanda Yun Rui Lam, Huang Fang Zheng, Kok Keong Teo, Xiao Hui Xin, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Hong Chang Tan

Division of Basic Science Faculty Publications

No abstract provided.


Autonomic And Enteric Profiling May Help Predict Response To Diverse Obesity Therapies, Michael Eiswerth, Prateek Mathur, Hani Rashed, Frank Greenway, Eric Ravussin, William Johnson, Pichamol Jirapinyo, Christopher C. Thompson, Farid Kehdy, Shabnam Sarker, Le Yu Naing, Michael W. Daniels, Thomas Abell Sep 2024

Autonomic And Enteric Profiling May Help Predict Response To Diverse Obesity Therapies, Michael Eiswerth, Prateek Mathur, Hani Rashed, Frank Greenway, Eric Ravussin, William Johnson, Pichamol Jirapinyo, Christopher C. Thompson, Farid Kehdy, Shabnam Sarker, Le Yu Naing, Michael W. Daniels, Thomas Abell

Clinical Research Faculty Publications

Purpose: Changes in autonomic (ANS) and enteric nervous systems (ENS) may be involved in pathogenesis of obesity. We hypothesized that baseline autonomic and enteric parameters may predict outcomes of diverse obesity therapies. Material and Methods: We studied ANS and ENS physiology in 37 patients (8 male, 29 female, age 45 years, weight 129.7 kg) at 4 centers in patients undergoing medical (9: low-calorie diet) versus invasive (22: 16 sleeve, 6 bypass) and semi-invasive (6: 2 band, 2 high energy stimulation, 2 aspiration) weight loss therapies. Weight loss was reported as percent weight loss from baseline to latest values at 1 …


Effect Of Impaired Awareness Of Hypoglycemia On Glucose Decline During And After Exercise In The T1dexi Study, Jorge L. Jo Kamimoto, Zoey Li, Robin L. Gal, Jessica R. Castle, Francis J. Doyle, Peter G. Jacobs, Corby K. Martin, Roy W. Beck, Peter Calhoun, Michael C. Riddell, Michael R. Rickels Sep 2024

Effect Of Impaired Awareness Of Hypoglycemia On Glucose Decline During And After Exercise In The T1dexi Study, Jorge L. Jo Kamimoto, Zoey Li, Robin L. Gal, Jessica R. Castle, Francis J. Doyle, Peter G. Jacobs, Corby K. Martin, Roy W. Beck, Peter Calhoun, Michael C. Riddell, Michael R. Rickels

Clinical Research Faculty Publications

Context: Adults with type 1 diabetes (T1D) face the necessity of balancing the benefits of exercise with the potential hazards of hypoglycemia. Objective: This work aimed to assess whether impaired awareness of hypoglycemia (IAH) affects exercise-associated hypoglycemia in adults with T1D. Methods: We compared continuous glucose monitoring (CGM)-measured glucose during exercise and for 24 hours following exercise from 95 adults with T1D and IAH (Clarke score ≥4 or ≥1 severe hypoglycemic event within the past year) to 95 “aware” adults (Clarke score ≤2 and no severe hypoglycemic event within the past year) matched on sex, age, insulin delivery modality, and …


Covid-19 Implications On Worksite Wellness Programming, Renee A. Underwood, Angela R. Wood, Ralph J. Wood, Rylie B. Broussard, Stephanie T. Broyles Sep 2024

Covid-19 Implications On Worksite Wellness Programming, Renee A. Underwood, Angela R. Wood, Ralph J. Wood, Rylie B. Broussard, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

Seven of the top ten leading causes of death in the United States are due to chronic diseases and treating these accounts for 86 percent of our nation's health care costs. The workplace offers an environment to implement chronic disease prevention strategies, such as worksite wellness programs, due to the large amount of time spent at the worksite daily by employees. As a result of COVID-19, many organizations began to change their workdays (i.e., working from home). This research sought to understand what, if any, implications the COVID-19 epidemic had on worksite wellness programming. Semistructured interviews were employed and recorded …


Evaluating The Validity Of The Portionsize Smartphone Application For Estimating Dietary Intake In Free-Living Conditions: A Pilot Study, Hanim E. Diktas, Chloe P. Lozano, Sanjoy Saha, Stephanie T. Broyles, Corby K. Martin, John W. Apolzan Sep 2024

Evaluating The Validity Of The Portionsize Smartphone Application For Estimating Dietary Intake In Free-Living Conditions: A Pilot Study, Hanim E. Diktas, Chloe P. Lozano, Sanjoy Saha, Stephanie T. Broyles, Corby K. Martin, John W. Apolzan

Clinical Research Faculty Publications

Objective: Evaluate the validity of the PortionSize application. Methods: In this pilot study, 14 adults used PortionSize to record their free-living food intake over 3 consecutive days. Digital photography was the criterion measure, and the main outcomes were estimated intake of food (grams), energy (kilocalories), and food groups. Equivalence tests with ±25% equivalence bounds and Bland-Altman analysis were performed. Results: Estimated gram intake from PortionSize was equivalent (P < 0.001) to digital photography estimates. PortionSize and digital photography estimated energy intake, however, were not equivalent (P = 0.08), with larger estimates from PortionSize. In addition, PortionSize and digital photography were equivalent for vegetable intake (P = 0.01), but PortionSize had larger estimates of fruits, grains, dairy, and protein intake (P >0.07; error range 11% to 23%). Conclusions and Implications: Compared with digital photography, PortionSize accurately estimated food intake and had reasonable error rates for other nutrients; however, it overestimated energy intake, indicating …


Modification Of Childcare's Outdoor Setting For Toddler Physical Activity And Nature-Based Play: A Mixed Methods Study, Chelsea L. Kracht, Amanda E. Staiano, Melissa Harris, Kristin Domangue, Michelle Grantham-Caston Sep 2024

Modification Of Childcare's Outdoor Setting For Toddler Physical Activity And Nature-Based Play: A Mixed Methods Study, Chelsea L. Kracht, Amanda E. Staiano, Melissa Harris, Kristin Domangue, Michelle Grantham-Caston

Population and Public Health Science Faculty Publications

Background Toddler physical activity is critical for child health, but little is known about its applications in early childhood education (ECE) centers. The aims of this study were 1) to determine if pragmatic and nature-based modifications to an ECE center's outdoor setting were feasible and acceptable, and 2) to identify barriers and facilitators of toddler physical activity at ECE centers. Methods A multiphase mixed-methods study (QUANT+QUAL) was conducted. In the QUANT study, a stepped, sequential modification of the outdoor setting, using pragmatic and cost-effective nature-based elements, was conducted with a delayed control group over 10-weeks, with follow-up assessments 3-months later …


Nutrition Education For Refugees: Successful Strategies And Barriers, Jessica Smith, Habiba Nur, Martha Archuleta, Mateja R. Savoie-Roskos, Celina Wille, Casey Coombs, Heidi J. Wengreen Sep 2024

Nutrition Education For Refugees: Successful Strategies And Barriers, Jessica Smith, Habiba Nur, Martha Archuleta, Mateja R. Savoie-Roskos, Celina Wille, Casey Coombs, Heidi J. Wengreen

Journal of Human Sciences and Extension

Nutrition education can improve nutrition and health for refugees. Extension program directors providing nutrition education to refugees were surveyed regarding successful program techniques, program challenges, and both the barriers refugees face and the strengths they possess concerning healthy eating. Researchers used grounded theory to explore the qualitative data. Hands-on, skill-based learning emerged as a main theme of successful programs. Language and cultural issues emerged as main program challenges. It is recommended that future refugee nutrition education programs provide culturally sensitive opportunities for skill-based learning.


Postharvest Characterization And Storage Of Fresh Katmon Fruit (Dillenia Philippinensis), Leonisa A. Artes, Amparo A. Wagan, Michelle E. Omana, Leonardo L. Tamisin Jr Sep 2024

Postharvest Characterization And Storage Of Fresh Katmon Fruit (Dillenia Philippinensis), Leonisa A. Artes, Amparo A. Wagan, Michelle E. Omana, Leonardo L. Tamisin Jr

The Philippine Agricultural Scientist

Katmon fruit has great economic potential but little is known about its postharvest behavior. This study characterized the katmon fruit after harvest so that appropriate handling may be recommended to extend its shelf life during storage or market display. Physicochemical characteristics, particularly firmness, pH, total soluble solids (TSS), titratable acids (TA), and TSS:TA ratio were evaluated during storage under room condition (22°C) and at low temperature (15°C). These characteristics were almost constant under 22°C or at 15°C for two weeks, with pH at 2.8, TSS at about 3.40°Brix, TA at 1.1 – 1.5%, and TSS:TA ratio at 3.1 – 2.04. …


The Mutual Effects Of Pinching And Promalin® On Root Architecture In Two Boxwood Species, Omer Sari, Fisun Celikel Sep 2024

The Mutual Effects Of Pinching And Promalin® On Root Architecture In Two Boxwood Species, Omer Sari, Fisun Celikel

The Philippine Agricultural Scientist

Boxwoods are constantly pinched to shape and form hedges, and Promalin® application is used to boost their shoot yield. Having good root development is crucial for the healthy development of plants; however, the effects of such applications on plant root development have generally been ignored in previous studies. Hence, this study evaluated the effects of applications on the root growth of two boxwood species (Buxus sempervirens L. and Buxus balearica Lam.) during the summer dormancy period. Pinching and Promalin® (0, 1 000, 2 000, and 4 000 ppm) were applied to one-year-old seedlings at three different times. Results showed …


Growth-Promoting Bacteria And Salicylic Acid Improve Essential Oil, Flower Yield, And Compatible Osmolyte Content Of Common Yarrow (Achillea Millefolium L.) Under Drought Stress, Mohsen Zarepour, Mohammad Mehdi Rahimi, Abdul Samad Kelidari, Moslem Abdipour Sep 2024

Growth-Promoting Bacteria And Salicylic Acid Improve Essential Oil, Flower Yield, And Compatible Osmolyte Content Of Common Yarrow (Achillea Millefolium L.) Under Drought Stress, Mohsen Zarepour, Mohammad Mehdi Rahimi, Abdul Samad Kelidari, Moslem Abdipour

The Philippine Agricultural Scientist

Drought is one of the major constraints on agricultural productivity in arid and semiarid regions. Coping with drought stress involves several adaptations and mitigation strategies such as the use of plant-growth promoting bacteria and salicylic acid, which was examined in this study under two levels of water regimes (well-watered as control and drought stress) in southwest Iran in 2018 and 2020 on common yarrow (Achillea millefolium). Catalase levels significantly increased in response to drought stress and salicylic acid application. Salicylic acid and combined application treatment of both bacteria also resulted in a significant increase in proline compared with …


Effect Of Stocking Density On Growth, Biochemical Composition, And Blood Parameters In The Pacific Shortfin Eel (Anguilla Bicolor Pacifica) Elvers, Frolan A. Aya, John Carlo L. Unida, Luis Maria B. Garcia, Rowena R. Eguia Ma. Sep 2024

Effect Of Stocking Density On Growth, Biochemical Composition, And Blood Parameters In The Pacific Shortfin Eel (Anguilla Bicolor Pacifica) Elvers, Frolan A. Aya, John Carlo L. Unida, Luis Maria B. Garcia, Rowena R. Eguia Ma.

The Philippine Agricultural Scientist

This study examined the effect of stocking density on growth, biochemical composition, and blood parameters of the Pacific shortfin eel Anguilla bicolor pacifica. Elvers (1.95 ± 0.14 g body weight) were randomly stocked in indoor tanks and reared over 186 d at three stocking densities (0.3, 0.6, and 0.9 kg m-3) set up in triplicates. Except for survival and biometric indices, elvers maintained at 0.3 and 0.6 kg m-3 densities exhibited higher growth and feed utilization than those held at 0.9 kg m-3. Yield increased with stocking density, which were significantly higher at 0.6 …


Unl Emeriti And Retirees Association Newsletter, September 2024 Sep 2024

Unl Emeriti And Retirees Association Newsletter, September 2024

UNL Emeriti and Retirees Association: Newsletters and Other Materials

University of Nebraska-Lincoln Emeriti and Retirees Association Newsletter, September 2024


Ectogenesis And The Value Of Gestational Ties, Susan Kennedy Sep 2024

Ectogenesis And The Value Of Gestational Ties, Susan Kennedy

Philosophy

Ectogenesis technology would make it possible to support the complete gestational development of a human being outside the female body. Proponents argue that this technology offers a welcome opportunity to expand reproductive options for those unable or unwilling to gestate. However, by completely bypassing pregnancy, the use of ectogenesis prevents the formation of gestational family ties. Consequently, it has faced criticism for perpetuating a patriarchal view of the family that undermines the moral significance of gestation. The concern is that the introduction of this technology might result in the loss of reproductive autonomy for those who desire to experience pregnancy, …


Autophagy And Meiotic Fidelity In C. Elegans, Kaitlin E. Kosinski Sep 2024

Autophagy And Meiotic Fidelity In C. Elegans, Kaitlin E. Kosinski

Dissertations, Theses, and Capstone Projects

Autophagy is an evolutionarily conserved multi-step recycling process in which cellular material is enclosed in the double membrane-bound autophagosome, which fuses with the lysosome to degrade its contents. Autophagy is essential for development and cellular adaptation to environmental or intracellular stress and is an important regulator of germline stem cell homeostasis in the model nematode C. elegans. We sought to determine if autophagy is important for genome stability during meiosis and found that the core adult C. elegans autophagy genes bec-1, atg-7, unc-51, and atg-18 were all required for proper meiotic development of oocytes. Loss of these …