Digital Commons Network^™

Biological Computing From Microscopic To Macroscopic Evolution, Xiaofeng Ding

Masters Theses

A unified theory from microscopic to macroscopic DNA-based biological systems is explained in terms of the rule components used when the system size is increased. Even though the eight female rules in each ruleset are provided with an equal probability of the computation-state outcomes, the initial ensemble of the computation states will exponentially settle into one dominant rule that supports the nutrition needed for growth. The remaining seven rules form into two minority groups to provide the biological characteristics of the system's growth from a micro to macroscopic evolution. The object of this study is to prove that such a …

Thermal Inactivation Of E. Faecium On Ground Poultry, Joseph Katz

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chicken products in grocery stores are contaminated with Salmonella that is ranked number one as a foodborne pathogen, and causes about 1.35 million cases of foodborne illness, 26,500 hospitalizations, and 420 deaths annually. The objective of this study is to determine thermal kinetic parameters of Salmonella surrogate bacteria E. faecium in ground poultry as affected by different temperatures and salt concentrations. The raw chicken was sliced up into a 500 g batch with a total of 6 batches per replicate, ground up in the meat grinder followed by inoculation with E. faecium resistant to 200 ppm Nalidixic Acid. NaCl …

The Use Of An In Chemico Digestibility Assay To Reduce The In Vivo Fish Bioaccumulation Testing Of Nanomaterials, Craig Mchardy, Nathaniel J. Clark, Robert Clough, Richard D. Handy

School of Biological and Marine Sciences

Currently for engineered nanomaterials (ENMs), there are no alternatives to bioaccumulation testing in fish as prescribed by OECD TG 305. New approaches are being sought, in order to reduce the numbers of animals used and address the ethical concerns associated with the use of vertebrates in such testing. This study aimed to demonstrate the value of an alternative method — the in chemico digestibility assay — as a tool to assess the bioaccumulation potential of ENMs. Titanium dioxide ENMs, or their equivalent bulk form, were incorporated onto a commercial fish diet and the fish digestion process was simulated in vitro …

A Multifactorial Approach To Improve Piglet Health And Survival, Aryeri Stephanie Bardales Castellanos

Electronic Theses and Dissertations

Pre-weaning mortality (PWM) remains a significant challenge in modern swine production systems, particularly in the context of hyper prolific sows. Although genetic selection has successfully increased litter sizes, these advancements have also intensified physiological stress on sows and increased the vulnerability of neonatal piglets. The majority of PWM occurs within the first 72 hours postpartum, with crushing by the sow as the leading cause of death. Additionally, iron deficiency anemia remains one of the most widespread nutritional disorders in piglets, further compromising survival, immune function, and growth. This thesis adopts a multifactorial approach to evaluate two management interventions aimed at …

What Do We Get Out Of Our Entertainment? Empirically Determining The Differences Between Narrative Engagement And Flow Using Video Games, Lars Wagener

Electronic Theses and Dissertations

Immersion is an important aspect of entertainment media because it both drives the use of media and heightens one’s experience with that media (Nilsson et al., 2016). There are three core aspects of immersion. These aspects are (1) narrative engagement, (2) flow, and (3) enjoyment. This study set out to determine whether these aspects are statistically distinct from one another when observed in video games. The result indicated that these aspects were distinct from one another when examined through a structural equation model. This indicates that creating an overarching immersion variable that combines the different aspects of immersion may not …

The Effects Of Flaxseed Oil-Based Supplementation On Feeding Behavior, Performance, Follicular Dynamics, And Embryo Production In Beef Cattle, Kendal Lynn Green

Electronic Theses and Dissertations

This review seeks to provide an overview of fatty acid supplementation in cattle, opening with their structural and functional properties. Nutritional supplementation helps to regulate the precursors and substrates crucial to reproduction. This review aims to examine nutritional supplementation strategies, the role of fatty acids on follicular dynamics, and their impact on embryo production. The base of literature regarding lipid supplementation is vast, with varying results found across studies. Comparing results from prior studies remains difficult as there is a vast range of lipid sources used in beef and dairy animals. The emphasis of this review was placed on evaluating …

Management Strategies To Improve Gastrointestinal Health And Productivity Of Native And Dairy-Derived Steers Fed In Confinement, Becca B. Grimes Francis

Electronic Theses and Dissertations

The objective of this dissertation was to evaluate strategies to mitigate metabolic disorders in confinement fed steers. The first study was conducted on yearling beef steers to investigate the effect of a rumen buffer, calcium magnesium carbonate (CMC), when fed with or without tylosin phosphate (TYL), on growth performance, rumination activity and liver abscess prevalence. Supplementation of a rumen buffer was not an effective alternative to a feed-grade antimicrobial for the control of liver abscesses in beef steers. Supplementation of CMC reduced DMI, thus negatively influencing BW and ADG. No associative effects of CMC and TYL were observed for any …

Impact Of Natural Feed Additives And Monensin Sodium On Growth Performance In Feedlot Cattle, Thiago Lauro Maia Ribeiro

Electronic Theses and Dissertations

The objective of this dissertation was to investigate how phytogenic feed additives and a pulse feeding monensin sodium strategy would affect growth performance in the receiving and finishing feedlot phases. Three randomized complete block design feedlot experiments and one pooled analysis were conducted to determine the effects of the feed additives and management strategies used in newly weaned and finishing beef cattle. The objective of these experiments were 1) determine if a blend of capsicum oleoresin, clove essential oil, and garlic essential oil (CCG) influences cattle performance, sera metabolites or health outcomes during the feedlot receiving phase; 2) determine if …

In The Footsteps Of Moose: Using Non-Invasive Techniques To Identify Cause-Specific Calf Mortalities And Evaluate Moose (Alces Alces) Movements Pertaining To Mineral Lick Locations On Ancestral Lands Of The Grand Portage Ojibwe, Anna B. Weesies

Electronic Theses and Dissertations

Following a sharp moose (Alces alces; mooz, Anishinaabemowin, Ojibwe language) population decline in northeastern Minnesota during the early 2000s, the Grand Portage Band of Lake Superior Chippewa initiated a long-term moose collaring effort to assess survival and mortality causes. Moose are a culturally important species to the Band, with annual subsistence hunts held on the Reservation and adjacent 1854 Ceded Territory. Continued research guides culturally appropriate management decisions aimed at bolstering calf and adult survival, helping to preserve this moose in Minnesota today and for subsequent generations. Chapter 1 identifies cause-specific calf mortality rates in this multi-predator system using minimally …

Dual Inhibitor Of Mdm2 And Nfat1 For Experimental Therapy Of Breast Cancer: In Vitro And In Vivo Anticancer Activities And Newly Discovered Effects On Cancer Metabolic Pathways, Wei Wang, Marlene Aguilar, Sayantap Datta, Abigail Alley, Meheret Tadesse, Xinshi Wang, Xia Gao, Ruiwen Zhang

Faculty, Staff and Students Publications

INTRODUCTION: The oncogene MDM2 has garnered attention not only for its role in cancer as a negative regulator of the tumor suppressor p53 but also for its p53-independent oncogenic activities. MDM2 also involves metabolic reprogramming, such as serine metabolism, respiration, mitochondrial functions, the folate cycle, and redox balance. Traditional MDM2 inhibitors blocking the protein-protein binding between MDM2 and p53 have shown limited clinical success in various stages of clinical trials, most likely due to low efficacy, drug toxicity, and drug resistance, highlighting the need for a novel, p53-independent strategy to inhibit MDM2. The present study investigated the antitumor effects of …

Predictive Equation Derived From 6,497 Doubly Labelled Water Measurements Enables The Detection Of Erroneous Self-Reported Energy Intake, Rania Bajunaid, Chaoqun Niu, Catherine Hambly, Zongfang Liu, Yosuke Yamada, Heliodoro Aleman-Mateo, Liam J Anderson, Lenore Arab, Issad Baddou, Linda Bandini, Kweku Bedu-Addo, Ellen E Blaak, Carlijn V C Bouten, Soren Brage, Maciej S Buchowski, Nancy F Butte, Stefan G J A Camps, Regina Casper, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Peter S W Davies, Prasangi Dabare, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Melanie Gillingham, Annelies H Goris, Michael Gurven, Asmaa El Hamdouchi, Hinke H Haisma, Daniel Hoffman, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Misaka Kimura, William E Kraus, Wantanee Kriengsinyos, Rebecca Kuriyan, Robert F Kushner, Estelle V Lambert, Pulani Lanerolle, Christel L Larsson, William R Leonard, Nader Lessan, Marie Löf, Corby K Martin, Eric Matsiko, Anine C Medin, James C Morehen, James P Morton, Aviva Must, Marian L Neuhouser, Theresa A Nicklas, Christine D Nyström, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca Reynolds, Susan B Roberts, Dulani Samaranayakem, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Marina Stamatiou, Eric Stice, Samuel S Urlacher, Ludo M Van Etten, Edgar G A H Van Mil, George Wilson, Jack A Yanovski, Tsukasa Yoshida, Xueying Zhang, Alexia J Murphy-Alford, Srishti Sinha, Cornelia U Loechl, Amy H Luke, Herman Pontzer, Jennifer Rood, Hiroyuki Sagayama, Dale A Schoeller, Klaas R Westerterp, William W Wong, John R Speakman

Faculty, Staff and Students Publications

Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes with the total energy expenditure (TEE). In this study, we used the International Atomic Energy Agency Doubly Labeled Water Database to derive a predictive equation for TEE using 6,497 measures of TEE in individuals aged 4 to 96 years. The resultant regression equation predicts expected TEE from easily acquired variables, such as body weight, age and sex, with 95% predictive limits that can be used …

From Trials To Practice: Implementing A Clinical Intervention In Community Settings, Elizabeth M Vaughan, Xiaoying Yu, Victor J Cardenas, Craig A Johnston, Salim S Virani, Ashok Balasubramanyam, Christie M Ballantyne, Aanand D Naik

Faculty, Staff and Students Publications

Introduction/objectives: Diabetes increases the risk of complications, especially for vulnerable populations. Our previous randomized clinical trial (RCT), TIME (Telehealth-supported, Integrated Community Health Workers (CHWs), Medication access, group visit Education), showed the efficacy of CHW-led diabetes care. This study aimed to gather data on transitioning TIME from clinical trials to practical implementation.

Methods: We conducted a 12-month RCT at a nonprofit community clinic using the Consolidated Framework for Implementation Research (CFIR). Participants, Hispanic adults without insurance and with type 2 diabetes (N = 58; 29/arm), were randomized to TIME (intervention) or usual care (control). The intervention included monthly group visits and …

Records Of The Wilmore Day Care Center Arc 2025-005 - Finding Aid, Ats Special Collections And Archives

Finding Aids

No abstract provided.

Age-Related Variations In Hba1c Improvemecnts: Insights From A Telehealth-Supported Community-Based Intervention, Laura Porterfield, Xiaoying Yu, Amber B Amspoker, Craig A Johnston, Aanand D Naik, Salim S Virani, Christie M Ballantyne, Ashok Balasubramanyam, Elizabeth M Vaughan

Faculty, Staff and Students Publications

Background and objectives: We previously demonstrated that a telehealth-supported community health worker (CHW) intervention significantly improved clinical outcomes in diabetes care. However, the extent to which these benefits vary across different age groups remains unclear. This study evaluated the effectiveness of a CHW-led multidimensional diabetes intervention in reducing HbA1c across age groups.

Research design and methods: We conducted a retrospective analysis of 10 studies (n = 301) that focused on low-income Hispanic adults with or at risk for type 2 diabetes. The intervention included CHW-participant coaching via mobile Health (mHealth), monthly CHW-led group education, and bidirectional mHealth feedback among …

Minimum Standards For Training In Colorectal Endoscopic Mucosal Resection Among Advanced Endoscopy Trainees, Dennis Yang, Ernesto Robalino Gonzaga, Muhammad Khalid Hasan, Arvind Julius Trindade, Mark Radlinski, Rebecca A Burbridge, Jeffrey Mosko, Pushpak Taunk, Salmaan Jawaid, Mohamed O Othman, David L Diehl, Harshit S Khara, Quin Liu, Srinivas Gaddam, Harry Aslanian, Shailendra S Chauhan, Amrita Sethi, John Poneros, Jason Samarasena, Ali M Ahmed, Uzma D Siddiqui, Dennis Chen, Moamen Gabr, Andrew Y Wang

Faculty, Staff and Students Publications

Background and study aims: Data on colorectal endoscopic mucosal resection (C-EMR) training during advanced endoscopy fellowship remain limited. We aimed to determine the number of procedures required by an "average" advanced endoscopy trainee (AET) to achieve competence in cognitive and technical C-EMR skills.

Methods: AETs from advanced endoscopy training programs (AETPs) were graded on every C-EMR using a standardized assessment tool. Cumulative sum (CUSUM) analysis was used to generate individual and aggregate learning curves to estimate the minimum number of cases required to achieve competence for overall, technical, and cognitive components of C-EMR. AETs completed a self-assessment questionnaire on C-EMR …

Prospective Multicenter Longitudinal Measurement Of Liver Stiffness In School-Age Children With Cholestatic Liver Disease, Benjamin L Shneider, Nathan P Goodrich, Wen Ye, Jean P Molleston, Daniel H Leung, Ronald J Sokol, Laurel Cavallo, Kasper Wang, Pamela L Valentino, Jeffery H Teckman, James E Squires, Shikha S Sundaram, Philip Rosenthal, Rene Romero, Alexander G Miethke, Kathleen M Loomes, Rohit Kohli, Saul J Karpen, Binita M Kamath, M Kyle Jensen, Jorge A Bezerra, Lee M Bass, John C Magee, Children

Faculty, Staff and Students Publications

Background and aims: A multicenter prospective longitudinal study of vibration-controlled transient elastography (VCTE) in school-age children with biliary atresia (BA), alpha-1 antitrypsin deficiency (a1-AT) and Alagille syndrome (ALGS) was undertaken to test the hypothesis that there would be measurable disease progression over 2 years.

Methods: Vibration-controlled transient elastography was performed annually for 2 years in children with BA, a1-AT and ALGS.

Results: Valid liver stiffness measurement (LSM) was determined at baseline/second follow-up in 254/180 (71%), 104/58 (56%) and 100/61 (61%) participants (mean elapsed time 2.27 years) with BA, a1-AT and ALGS, respectively. Modeling did not reveal a relationship between LSM …

Resilience Of The Gut Microbiome To Short Proton Pump Inhibitor Therapy With Or Without High-Dosage L Reuteri In H Pylori-Infected Adults, Stefano Bibbò, Gustav Ahlström, Giovanni Mario Pes, David Y Graham, Lars Engstrand, Elettra Merola, Maria Pina Dore

Faculty, Staff and Students Publications

Background: Helicobacter pylori eradication therapy typically consists of a combination of antibiotics and an antisecretory drug. Probiotics may be added to reduce side effects and possibly improve outcomes.

Materials and methods: We conducted a double-blind, randomized trial of pantoprazole plus either Lactobacillus reuteri (Gastrus) (high dose) or a matching placebo to assess the impact on the gut microbiota of H. pylori-positive adults. Fecal samples were collected at baseline and after one and 2 months for shotgun metagenomic sequencing.

Results: A total of 26 patients were recruited and completed therapy. L. reuteri was only detected in the group that received supplemental …

The Association Of Human Milk Intake And Outcomes In Biliary Atresia, Mary Elizabeth M Tessier, Jeremy M Schraw, Stacey Beer, Sanjiv Harpavat, M Kyle Jensen, John C Magee, Vicky Ng, Michael E Scheurer, Sarah A Taylor, Benjamin L Shneider

Faculty, Staff and Students Publications

Objectives: Human milk intake has many benefits which could influence outcomes in biliary atresia (BA). However, the role of human milk in BA has not been examined. We hypothesized that human milk intake would be associated with improved outcomes in BA.

Methods: We assessed the impact of any human milk (AHM) as compared to formula only (FO) intake before Kasai portoenterostomy (KP) on outcomes in 447 infants with BA using the PROBE database (NCT00061828) post hoc. The primary outcome was clearance of jaundice (COJ = total bilirubin (TB) < 2 mg/dL by 3 months post-KP). Secondary outcomes included 2-year survival with native liver (SNL), bilirubin levels, cholangitis, ascites, and growth. We assessed the fecal microbiome (n = 8) comparing AHM versus FO.

Results: At baseline, 211 infants received AHM and 215 received …

Favorite Foods Participant Packet, Caitlin Wollack

UNH Cooperative Extension

No abstract provided.

Cheshire 4-H Presents 2026 Information Packet, Diane Dugray

UNH Cooperative Extension

No abstract provided.

Hemp Pests In New Hampshire, Amber Vinchesi-Vahl, William Hastings

UNH Cooperative Extension

No abstract provided.

Good Forestry In The Granite State: Appendices & References, Cooperative Extension

UNH Cooperative Extension

No abstract provided.

Wellness Wheel Action Guide Fillable Form, Michele Kroll

UNH Cooperative Extension

No abstract provided.

4-H Pledge To Create Smart Goals, Kristen Lyons

UNH Cooperative Extension

No abstract provided.

Grand Challenges For Human Factors And Ergonomics, Waldemar Karwowski, Gavriel Salvendy, Mica Endsley, William Rouse, Paul Salmon, Kay Stanney, Andrew Thatcher, Tony Andre, Jessie Yang, Hasan Ayaz, Ahmet Cakir, Vince Duffy, Colin Drury, Qin Gao, Yinni Guo, Peter Hancock, William S. Marras, Patrick Rau

Faculty Research, Scholarly, and Creative Activity

Contemporary society faces a growing set of complex global issues representing significant human health, well-being, and sustainability threats. Human Factors and Ergonomics (HFE) has a critical role to play in responding to these issues; however, there remain a set of grand challenges that require resolution. This paper presents and discusses six grand challenges for HFE and related key research thrust areas for each of the challenges. The grand challenges are (1) Evolution in Societal Thinking; (2) Future of Human Work in Industry 5.0; (3) Climate Change and Sustainability; (4) Future of Education and Training; (5) Future of Personalized Health, and …

Gout Flare Burden In The United States: A Multiyear Cross-Sectional Survey Study, Jasvinder A Singh, Amy Morlock, Robert Morlock

Faculty, Staff and Students Publications

OBJECTIVE: The objective of this study was to assess the burden of gout flares and examine associated patient characteristics and outcomes in a sample of US adults.

METHODS: Data were collected via an online survey of US adults ≥18 years using a random stratified sampling framework. Participants with gout completed questions about treatments, serum urate (SU) levels, severity, satisfaction with control, and gout flares. All participants completed the Veterans RAND 12-Item Health Survey, the Generalized Anxiety Disorder 7-Item Scale, and the Patient Health Questionnaire 9-Item Scale. Data were summarized using descriptive statistics. Multivariable-adjusted logistic regression analyses examined factors predictive of …

Exploring The Relationship Between Health Literacy And Health Behavior Intention Through Mediation Moderation Analyses, Christopher M. Boerum

Electronic Theses and Dissertations 2020 - Present

Vaccine hesitancy is a complicated public health issue that could compromise the well-being of our communities, evident not only in the COVID-19 pandemic but also in the increasing occurrences of vaccine hesitancy toward long-established vaccines, leading to breakthrough cases of diseases such as measles. Several factors can impact this complex phenomenon, such as health education (HE), attitudes towards social media (SMA) and exercise (EA), chronic disease exposure/risk perception (CDR), and demographic variables.

This study examined the relationship between health literacy (HL), and health behavior intention. The eHeals assessment measured HL and an assessment of vaccine attitude (VA) measured health behavior …

Host-Associated Beneficial Gut Microbiota Boosts Induced Immunity And Limits Immune Deployment Costs In Bumblebees, Austin C. Calhoun, Teni Shosanya, Brenna K. Long, Jade K. Rehberger, Ben M. Sadd

Faculty Publications – Biological Sciences

1. Ecological immunology posits that variation in host resistance to infection may be attributed partly to the ecological and evolutionary costs of immunity. While the deployment of immune defence is necessary to combat pathogenic infection, hosts pay energetic and other costs for activation.
2. Host-associated beneficial microbiota have been shown to affect multiple host traits, including immunity, but how interactions with these microbial communities may mitigate the costs of immune activation remains an open question. For apid bees, including eusocial bumblebees, core members of the adult gut microbiota contribute to a variety of fitness-relevant traits and provide a key ecological and evolutionary …

Effectiveness And Safety Of Intravenous Iron Therapy In Outpatient Obstetrical Clinic For Treatment Of Iron-Deficiency Anemia During Pregnancy, Ellen M. Murrin, Olivia S. Lebeau, Lillian Singer, Mark A. Kassab, Peyton Kalan, Julie Costanzo, Scott A. Sullivan, George L. Maxwell, George R. Saade, Antonio F. Saad

Department of Obstetrics & Gynecology Faculty Publications

Background

Iron-deficiency anemia (IDA) affects over one-third of pregnant patients globally, contributing to severe maternal morbidity and adverse neonatal outcomes. Oral iron supplementation, while cost-effective, is limited by poor absorption, significant gastrointestinal side effects, and poor adherence. The use of intravenous (IV) iron addresses many of these concerns, including eliminating GI side effects and the need for daily therapy. However, administration of IV iron in pregnant patients is typically restricted to specialized infusion centers or hospitals due to concerns about acute side effects, cost, resource utilization, the need for fetal heart rate monitoring, and extended infusion times.

Methods

This descriptive …

Assessing Trophic Pathways In The Southern Indian River Lagoon Using Fatty Acid Markers, Joedeelee Rigdon

Electronic Theses and Dissertations 2020 - Present

The Indian River Lagoon (IRL) comprises over 200 Km of the Florida’s east coast and is a bar-built estuary making up one of the most biodiverse estuarine environments in North America. Toxins produced by increasingly frequent harmful algae blooms in the IRL are found throughout the food web, from zooplankton to fish, to apex predators. The impact of species characterized as harmful algae can be traced using fatty acid markers, as phytoplankton and algae that make up HABs produce characteristic poly-unsaturated fatty acids (PUFA), which have conservative ratios between trophic levels. This study measured the fatty acid composition of two …