Digital Commons Network^™

Conflict With Patient: Patient Against Vaccinations, Jacob Waitzman, Isabella Anton, Parnia Behinaein, Patrick Kollman, Samy Shelbaya, Yage Pi, Mariam Raheem

Patient Education Projects

No abstract provided.

Preclinical Repurposing Of Sitagliptin As A Drug Candidate For Colorectal Cancer By Targeting Cd24/Ctnnb1/Sox4-Centered Signaling Hub, Jing-Wen Shih, Alexander T H Wu, Ntlotlang Mokgautsi, Po-Li Wei, Yan-Jiun Huang

Faculty, Staff and Student Publications

Despite significant advances in treatment modalities, colorectal cancer (CRC) remains a poorly understood and highly lethal malignancy worldwide. Cancer stem cells (CSCs) and the tumor microenvironment (TME) have been shown to play critical roles in initiating and promoting CRC progression, metastasis, and treatment resistance. Therefore, a better understanding of the underlying mechanisms contributing to the generation and maintenance of CSCs is crucial to developing CSC-specific therapeutics and improving the current standard of care for CRC patients. To this end, we used a bioinformatics approach to identify increased CD24/SOX4 expression in CRC samples associated with poor prognosis. We also …

Novel Textbook Outcomes Following Emergency Laparotomy: Delphi Exercise, David N Naumann, Aneel Bhangu, Adam Brooks, Matthew Martin, Bryan A Cotton, Mansoor Khan, Mark J Midwinter, Lyndsay Pearce, Douglas M Bowley, John B Holcomb, Ewen A Griffiths, Beacon Collaborative

Faculty, Staff and Student Publications

Background: Textbook outcomes are composite outcome measures that reflect the ideal overall experience for patients. There are many of these in the elective surgery literature but no textbook outcomes have been proposed for patients following emergency laparotomy. The aim was to achieve international consensus amongst experts and patients for the best Textbook Outcomes for non-trauma and trauma emergency laparotomy.

Methods: A modified Delphi exercise was undertaken with three planned rounds to achieve consensus regarding the best Textbook Outcomes based on the category, number and importance (Likert scale of 1-5) of individual outcome measures. There were separate questions for non-trauma and …

Safeguarding And Homosexuality, James Mctavish,

Landas

The Church is actively working to promote and build up a culture of safeguarding. Those most vulnerable to abuse need care and protection. Sexual orientation is an important element to consider in safeguarding, as there are specific risks for homosexual persons, and persons with same-sex attraction (SSA) frequently experience abuse. In a sensitive and respectful way, this article examines the background elements regarding homosexuality and abuse and gives specific details that can help in formulating a vision of safeguarding that takes into account the specific reality of persons with SSA.

Targeting Dna Repair And Survival Signaling In Diffuse Intrinsic Pontine Gliomas To Prevent Tumor Recurrence, Monika Sharma, Ivana Barravecchia, Robert Teis, Jeanette Cruz, Rachel Mumby, Elizabeth K Ziemke, Carlos E Espinoza, Varunkumar Krishnamoorthy, Brian Magnuson, Mats Ljungman, Carl Koschmann, Joya Chandra, Christopher E Whitehead, Judith S Sebolt-Leopold, Stefanie Galban

Faculty, Staff and Student Publications

Therapeutic resistance remains a major obstacle to successful clinical management of diffuse intrinsic pontine glioma (DIPG), a high-grade pediatric tumor of the brain stem. In nearly all patients, available therapies fail to prevent progression. Innovative combinatorial therapies that penetrate the blood-brain barrier and lead to long-term control of tumor growth are desperately needed. We identified mechanisms of resistance to radiotherapy, the standard of care for DIPG. On the basis of these findings, we rationally designed a brain-penetrant small molecule, MTX-241F, that is a highly selective inhibitor of EGFR and PI3 kinase family members, including the DNA repair protein DNA-PK. Preliminary …

Postoperative Systemic Inflammatory Response Syndrome Predicts Increased Mortality In Patients After Elective Craniotomy, Liyuan Peng, Qi Gan, Yangchun Xiao, Jialing He, Xin Cheng, Peng Wang, Lvlin Chen, Tiangui Li, Yan He, Weelic Chong, Yang Hai, Chao You, Fang Fang, Yu Zhang

Department of Medical Oncology Faculty Papers

Introduction: Patients undergoing craniotomy are at high risk of perioperative morbidity and mortality due to excessive inflammatory responses. The purpose of the present study is to evaluate the prognostic utility of postoperative systemic inflammatory response syndrome (SIRS) in patients undergoing craniotomy.

Methods: We performed a retrospective cohort study of patients who underwent craniotomy between January 2011 and March 2021. SIRS was diagnosed based on two or more criteria (hypo-/hyperthermia, tachypnea, leukopenia/leukocytosis, tachycardia). We used univariate and multivariate analysis for the development of SIRS with postoperative 30-day mortality.

Results: Of 12,887 patients who underwent craniotomy, more than half of the patients …

Digital Divide In Rural Native American Homes: A Student Perspective, Chad R. Fenner, Cherie Noteboom, Omar El-Gayar

Research & Publications

Native American homes located in rural western North Dakota have seen increased availability of broadband and fiber optic Internet but continue to have low access numbers. Native American homes in the region located outside population centers continue to have difficulty accessing the Internet. Many households continue to struggle with economic factors compounded by the cost of a device to access the Internet for personal, educational, or employment use. A qualitative study with semi-structured interviews and the grounded theory method investigated the Native American home environment. Interviews were conducted with Native American students attending a state university with insight into diverse …

Gender Equity In Public Affairs Pedagogy: Structure, Content, And Practice For A More Inclusive Public Sector, Nicole M. Elias, Maria J. D’Agostino, Vanessa Diez, Erik Krause

Publications and Research

Gender is an important component of Diversity, Equity, and Inclusion (DEI) pedagogy in public affairs, yet gender remains largely absent from public affairs education in three central ways: how courses are structured, the content of courses, and the practice of pedagogy. This article explains the value and need for gender equitable pedagogy in public affairs curricula. We conduct a descriptive analysis of scholarship and best practices from leading think tanks and public advocacy research organizations. Ultimately, this work provides recommendations to strengthen gender equity pedagogy both inside the classroom and in public sector workplaces.

Heat Shock Factor 1 Directly Regulates Transsulfuration Pathway To Promote Prostate Cancer Proliferation And Survival, J Spencer Hauck, David Moon, Xue Jiang, Mu-En Wang, Yue Zhao, Lingfan Xu, Holly Quang, William Butler, Ming Chen, Everardo Macias, Xia Gao, Yiping He, Jiaoti Huang

Faculty, Staff and Students Publications

There are limited therapeutic options for patients with advanced prostate cancer (PCa). We previously found that heat shock factor 1 (HSF1) expression is increased in PCa and is an actionable target. In this manuscript, we identify that HSF1 regulates the conversion of homocysteine to cystathionine in the transsulfuration pathway by altering levels of cystathionine-β-synthase (CBS). We find that HSF1 directly binds the CBS gene and upregulates CBS mRNA levels. Targeting CBS decreases PCa growth and induces tumor cell death while benign prostate cells are largely unaffected. Combined inhibition of HSF1 and CBS results in more pronounced inhibition of PCa cell …

Dental Surgical Activity In Hospitals During Covid-19: A Nationwide Observational Cohort Study, J Booth, A J Fowler, R Pearse, P Dias, Y I Wan, R Witton, T E F Abbott

Peninsula Dental School

INTRODUCTION: The number of surgical extractions performed in hospitals in England remains unclear. This study reports the volume of surgical extractions conducted in hospitals and change in activity during the COVID-19 pandemic.

METHODS: We conducted a nationwide observational cohort study using Hospital Episode Statistics (HES) in England for patients undergoing surgical removal of a tooth (defined using OPSC-4 code F09) between April 1, 2015, and December 31, 2020. Procedures were stratified by age, gender, and urgency (elective or nonelective), reported using descriptive statistics, number, and percentage. We conducted post hoc modeling to predict surgical activity to December 2023. In addition, …

"Five Things Biblical Scholars Wish Theologians Knew" [Review] / Mcknight, Scot., Gerardo Oudri

Andrews University Seminary Studies (AUSS)

This is a book review

Carbon Footprint Certificate For Print Jobs, Hp Inc

Defensive Publications Series

In terms of utility, considering the carbon footprint of print jobs is essential for sustainable practices and environmental responsibility. By adopting eco-friendly measures, such as using recycled paper, optimizing printing processes, and reducing energy consumption, the print industry can minimize its impact on climate change and resource depletion.

Moreover, businesses and individuals can make informed choices when selecting printing services by considering their carbon footprint. Choosing printers with eco-certifications or those that actively promote sustainability can contribute to a more environmentally conscious print industry.

What's So Special About Defender Days?, Sarah Moss

The Voice

No abstract provided.

Core 100 And 399, Sarah Moss

The Voice

No abstract provided.

Surprise!, Sarah Moss

The Voice

No abstract provided.

From Grey To Green: Reflections On Establishing An Urban Garden At Trinity College Dublin, Mariana P. Silva, Anangi Sumalde, Eleanor Flora Mullen, Simon Benson, Rachel Joanne Goodband, Conor O'Reilly, Nour Boulahcen

European Journal of Food Drink and Society

Urban gardens can be a part of the combined efforts of many to combat climate change and the associated risks posed by rapid urbanisation. These gardens can take shape on private, communal, or institutional scales, including urban educational campuses, where the teaching of sustainable gardening along with general knowledge about nature and ecology can benefit students, staff, and the wider community. This reflective piece centres on the experience of developing the Trinity Urban Garden (TUG) at Trinity College Dublin in Ireland. While hoping to overcome the worry that the tiny, seemingly inhospitable plot may not allow for a garden to …

Exploring The Significance Of The Traditional Chef’S Uniform In Making Sense Of Professionalism In Culinary Arts Using Interpretative Phenomenological Analysis, Orla Mc Connell

European Journal of Food Drink and Society

Previous studies have found that professionalism is an important success factor for chefs. Yet, research on what professionalism “means” to chefs, and how they “make sense” of it, is currently underexplored. While there is some evidence of the significance of the traditional chef’s uniform in professional identity formation, it also needs further consideration. Culinary arts lecturers and chefs have already contributed to these discussions, but the student voice remains largely unknown. Alongside this, there is no prior research specifically on professionalism in culinary arts in Ireland. Therefore, a research gap emerged, which this paper intends to address. Using interpretative phenomenological …

The Literary Gestalt Of The Restaurant Review, Anke Klitzing

European Journal of Food Drink and Society

The restaurant review is a quintessential form of gastronomic writing, but it has rarely been studied in terms of its literary form. This paper investigates the literary gestalt of restaurant reviews through a gastrocritical reading of two reviews by the Irish restaurant critic Helen Lucy Burke. It concludes that restaurant reviews typically include mimesis and evocative descriptions, a meal plot, inherent tension due to the performance character of the restaurant meal and incorporation anxiety, and a combination of phenomenological and ethnographic reporting. These literary features serve to make reviews an accurate and reliable account of the reviewer’s immersive experience, to …

Utilizing Culturally Responsive Strategies To Inspire African American Female Participation In Cybersecurity, Deanna Bailey, Michel Kornegay, Ladawn Partlow, Charnee Bowens, Karen Gareis, Kevin Kornegay

Journal of Pre-College Engineering Education Research (J-PEER)

The number of African American females participating in cyber fields is significantly low. Science, technology, engineering, and mathematics (STEM) education requires a new approach to student engagement to increase African American female participation in cybersecurity. The most common approach to engaging more African American females in STEM is to provide students access to professional images or role models active in STEM; however, more is needed. More race-centered strategies beyond role modeling are necessary to attract and retain African American females in STEM. Research studies show that integrating personal experiences and making cultural connections can help improve student participation in STEM …

Training Dataset Validation To Protect Machine Learning Models From Data Poisoning, Assaf Namer, Hauke Vagts, Jim Miller, Brandon Maltzman, Guy Rinkevich

Defensive Publications Series

Large language models (LLMs) and other machine learning models are trained on large amounts of curated text data, including both public and private datasets of variable quality. Data collection, cleaning, deduplication, and filtering are performed to build appropriate training datasets. However, such operations cannot protect the trained model against data poisoning (i.e., the intentional corruption of training data) that attempts to manipulate or compromise the behavior of the model. This disclosure describes techniques to improve data security and integrity of the training dataset for LLMs via data validation of a subset (or all) of the data points within the dataset …

“These Are Our Saints:” A Lourdes Shrine, The St. Coletta School For Exceptional Children, And The Catholic Remaking Of Cognitive Disability, Andrew Walker-Cornetta

Religion

This chapter appears from the book American Patroness: Marian Shrines and the Making of US Catholicism by Katherine Dugan and Karen E. Park, Editors.

"'These Are Our Saints:' A Lourdes Shrine, the St. Coletta School for Exceptional Children, and the Catholic Remaking of Cognitive Disability" focuses on a Lourdes shrine on the campus of what was once perhaps the most celebrated institution in the United States for persons with cognitive disabilities. It takes this site as a window onto mid-twentieth century Catholic efforts to re-imagine cognitive difference and highlights the importance of Marian devotional grammars to those efforts.

Teaching Law In The Age Of Generative Ai, John Bliss

Sturm College of Law: Faculty Scholarship

With the rise of large language models capable of passing law school exams and the Uniform Bar Exam, how should legal educators prepare their students for an age of transformative technological change? As text-generating AI is being integrated in legal research platforms and word processing software, which automate the drafting of legal documents based on human prompts, lawyers are increasingly adopting this technology as a standard tool of legal research and writing. This Article explores the implications of these developments for legal education, focusing on pedagogy, curriculum, and assessment.

The Article draws from four key perspectives relevant to the use …

Bitcoin Bubbles And A Monetary Measure Of Fundamental Value, Paul Hallwood

Pennsylvania Economic Review

Several papers estimate the time series properties of bitcoin prices. However, to know that bubbles occur, an estimate of fundamental value is needed. Few estimates of bitcoin’s fundamental price exist, and these are either statistical in nature or based on questionable economic theory. This paper calculates the non-bubble dollar price of bitcoin using a modification to the quantity theory of money, and it is estimated to be about $54.00. At the November 2021 peak market price of bitcoin, the bubble component was more than 99%. Even at end-August 2023 after bitcoin prices had more than halved, the bubble component was …

Inpatient Costs Of Treating Patients With Covid-19, Kandice A Kapinos, Richard M Peters, Robert E Murphy, Samuel F Hohmann, Ankita Podichetty, Raymond S Greenberg

Faculty, Staff and Student Publications

IMPORTANCE: With more than 6.2 million hospitalizations due to COVID-19 in the US, recognition of the average hospital costs to provide inpatient care during the pandemic is necessary to understanding the national medical resource use and improving public health readiness and related policies.

OBJECTIVE: To examine the mean cost to provide inpatient care to treat COVID-19 and how it varied through the pandemic waves and by important sociodemographic patient characteristics.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used inpatient-level data from March 1, 2020, to March 31, 2022, extracted from a repository of clinical, administrative, and financial information covering 97% …

Crispr-Cas9 Base Editing Of Pathogenic Camkiiδ Improves Cardiac Function In A Humanized Mouse Model, Simon Lebek, Xurde M Caravia, Leon G Straub, Damir Alzhanov, Wei Tan, Hui Li, John R Mcanally, Kenian Chen, Lin Xu, Philipp E Scherer, Ning Liu, Rhonda Bassel-Duby, Eric N Olson

Faculty, Staff and Student Publications

Cardiovascular diseases are the most common cause of worldwide morbidity and mortality, highlighting the necessity for advanced therapeutic strategies. Ca2+/calmodulin-dependent protein kinase IIδ (CaMKIIδ) is a prominent inducer of various cardiac disorders, which is mediated by 2 oxidation-sensitive methionine residues within the regulatory domain. We have previously shown that ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing enables the heart to recover function from otherwise severe damage following ischemia/reperfusion (IR) injury. Here, we extended this therapeutic concept toward potential clinical translation. We generated a humanized CAMK2D knockin mouse model in which the genomic sequence encoding the entire regulatory domain was …

Holy Cross Magazine, Vol. 58, No. 1, Winter 2024, College Of The Holy Cross

Holy Cross Magazine

It Scares Us To Death — And We Love It

Why are we fascinated with things we should fear, and why at Holy Cross is a dusty storage space home to the campus’ most persistent (and unsubstantiated) legend?
Feature by Marybeth Reilly-McGreen ’89

I’ve Jumped in a Lake More Than 1,200 Days in a Row. Here’s What I’ve Learned.
Essay by Dan O’Conor ’90

Suppose We All Presupposed?
How St. Ignatius’ instruction issued 500 years ago could improve your daily life.
Essay by Michele Murray

Tell Us a Story, Jonathan Kruk
For 35 years, storyteller Jonathan Kruk ’77 has been …

Enhancing The Zebra Optimization Algorithm With Chaotic Sinusoidal Map For Versatile Optimization, D Anand, Osamah Ibrahim Khalaf, G Rajesh Chandra

Iraqi Journal for Computer Science and Mathematics

In this study, the Chaotic Sinusoidal Map (CSM)-enhanced Zebra Optimization Algorithm (CZOA) is introduced. CZOA combines CSM's integration strengths with ZOA's optimization skills. ZOA already exhibits great optimization capabilities, but the addition of CSM increases its potential even more. This addition greatly strengthens ZOA's exploration and exploitation skills and increases its flexibility for various optimization tasks. CZOA outperforms both the original ZOA and contemporary optimisation methods on23 benchmark functions, including high-dimensional (FD), multimodal (MM), and unimodal (UM) challenges. Using the chaos of CSM to investigate regional optimal and determine better convergence and exploration-exploitation equilibrium are shown by CZOA, which also …

A Novel Method For Hill Cipher Encryption And Decryption Using Gaussian Integers Implemented Inbanking Systems, Saba Abdulbaqi Salman, Yasmin Makki Mohialden, Abbas Abdulhameed, Nadia Mahmood Hussien

Iraqi Journal for Computer Science and Mathematics

Cryptographic tools like Hill's encryption algorithm protect digital data. In this work, we present a novel Hill cipher security method that utilizes Gaussian integers from number theory. Using these intriguing mathematical entities to disguise plaintext values dramatically boosts assault resistance and duration.This research includes a three-pass protocol for encryption and decryption without key exchange, ensuring a safe, efficient, and dependable solution. Pandas is used for efficient data processing, and Numpy for computational tasks, notablymatrices.Hill cipher-based encryption and decryption can be utilized in real life. It also demonstrates how to save Pandas DataFrame data to Excel. This strategy assures progress in …

Detecting Arabic Misinformation Using An Attention Mechanism-Based Model, Bashar M. Nema, Mohammed Haqqi Al-Tai

Iraqi Journal for Computer Science and Mathematics

The proliferation of fake news or misinformation, commonly referred to as fake news, has a significant effect on a global scale, as it is aimed at influencing public opinion as well as crowd decision-making. It istherefore crucial to verifythe truthfulness of news before it is released to the public. Today, most studies on early detection of Arabic misinformation rely on machine learning methods and transformer-based models. Therefore, in the current study, we used deep learning techniques to propose a model for detecting Arabic misinformation by leveraging the contextual features of news article content. The proposed model was built based on …

Federal Court Blocks Parts Of Iowa’S ‘Don’T Say Gay’ Law, Arthur S. Leonard

Other Publications

No abstract provided.