Digital Commons Network^™

Targeting Ribosome Biogenesis For Pancreatic Cancer Treatment, Carlos Perez Iii

Theses and Dissertations

Pancreatic cancer (PanCa) is one of the leading causes of cancer-related death in the United States. Currently, PanCa is one of the recalcitrant cancers that has very limited therapeutic options available for its treatment. The current standard care of PanCa is gemcitabine (GEM) alone or in combination with FOLFIRINOX, nab-paclitaxel, erlotinib, or 5-FU PanCa, which often show poor response. Therefore, new treatment strategies are required for the prevention and treatment of cancer. Ribosome biogenesis process is dysregulated in most of the cancer types of results in production of more ribosomes and synthesis of oncoproteins which lead to the induction, progression, …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 71, Issue 2, Summer 2022

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• 4 - Dean's Column
• 8 - Time Capsule - Dr. Marion Siegman
• 11 - A Message from Elizabeth A. Dale
• 14 - ICYMI (In Case You Missed It)
• 18 - At the Intersection of Health and Design
• 20 - Discovery - A Path Toward Digital Equity
• 26 - Mark L. Tykocinski Takes the Helm as President of Thomas Jefferson University
• 28 - Student Profile - Kayla Holston
• 30 - Faculty Profile - Stephen D. Silberstein, MD
• 34 - Alumni Profile - Mahesh Krishnan, MD ’94
• 36 - Class Notes
• 42 - Reimagine
• 43 - Bookshelf
• 44- In …

Sped 874: Language Arts And Literacy For Students Who Are Deaf/Hard Of Hearing, Anne E. Thomas

UNL Faculty Course Portfolios

This portfolio documents the process I used to critically analyze the structure, teaching methods, assessment, and students learning in SPED 874 Language Arts and Literacy for Children who are Dear/Hard of Hearing. This is a course that students in the Deaf Education Program at the University of Nebraska-Lincoln (UNL) take while pursuing a master’s degree and/or graduate endorsement in Deaf Education. This portfolio documents how I aligned the course objectives, content, and activities to the Council for Exceptional Children - Initial Specialty Set for Teachers of the Deaf/Hard of Hearing (CEC-DHH). I share the results of one method I use …

Maternal Obesity, Pregnancy Weight Gain, And Birth Weight And Risk Of Colorectal Cancer, Caitlin C Murphy, Piera M Cirillo, Nickilou Y Krigbaum, Amit G Singal, Minjae Lee, Timothy Zaki, Ezra Burstein, Barbara A Cohn

Faculty, Staff and Student Publications

Objective: Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Obesity is a well-established risk factor for CRC, and fetal or developmental origins of obesity may underlie its effect on cancer in adulthood. We examined associations of maternal obesity, pregnancy weight gain, and birth weight and CRC in adult offspring.

Design: The Child Health and Development Studies is a prospective cohort of women receiving prenatal care between 1959 and 1966 in Oakland, California (N=18 751 live births among 14 507 mothers). Clinical information was abstracted from mothers' medical records 6 months prior to pregnancy through delivery. Diagnoses of …

Covid-19 Vaccines In India: Judicial Blind Spots In Upholding The Right To Health, Kajal Bhardwaj, Veena Johari

Socio-Legal Review

The COVID-19 pandemic brought to the forefront the intrinsic link between health and human rights and exposed the conflict between public health measures and individual rights and liberties. These conflicts are apparent in the context of COVID-19 vaccines as well. Vaccines were fast-tracked, given emergency approval and produced and distributed by a few manufacturers with the help of the government and multiple agencies, to control the COVID-19 pandemic. However, the lack of transparency in regulation, the formulation of arbitrary policies, unfair pricing, unequal procurement, restricted and discriminatory distribution, lack of informed consent and lack of accountability for adverse events following …

Child Sexual Abuse Cases In India And Judicial Officers’ Perceptions And Experiences Of Pocso-Related Special Training, Shailesh Kumar

Socio-Legal Review

Stakeholder training has been considered essential to tackle the problem of poor engagement with child sexual abuse (‘CSA’) victims in the pre-trial and trial stages of the criminal process. Be it stakeholder attitudes and behaviour towards the CSA victims and the accused involved in CSA cases or stakeholders’ procedural practices, more and improved training has been repeatedly emphasised. It is, therefore, pivotal to investigate what kind of special training is imparted to stakeholders under the Protection of Children from Sexual Offences (‘POCSO’) Act, 2012, as well as the challenges and limitations to such training. Also important is to analyse and …

Vanishing Twins Syndrome (Vts) - A Case Report, Meena Konsam Ms, Sonia R. B D'Souza Dr, Samir Kumar Praharaj Dr, Shyamala G Dr

Manipal Journal of Nursing and Health Sciences

Vanishing twin’s syndrome refers to the death of one of the co-twin foetus(es) during the early antenatal period. The cause of vanishing twins is unknown and most cases occur with in-vitro fertilization (IVF) conception. Transvaginal ultrasonography helps to detect lost twins during the early trimester. The complications that may arise among neonates born to women with a known history of vanishing twin syndrome are low birth weight and low Apgar score at birth.

Functional Genomic Analysis Of Epithelioid Sarcoma Reveals Distinct Proximal And Distal Subtype Biology, Samuel V Rasmussen, Jia Xiang Jin, Lissett R Bickford, Andrew D Woods, Felix Sahm, Kenneth A Crawford, Kiyo Nagamori, Hiroaki Goto, Keila E Torres, Angelo Sidoni, Erin R Rudzinski, Khin Thway, Robin L Jones, Alessio Ciulli, Hollis Wright, Melvin Lathara, Ganapati Srinivasa, Kavya Kannan, Paul H Huang, Thomas G P Grünewald, Noah E Berlow, Charles Keller

Faculty, Staff and Student Publications

Background: Metastatic epithelioid sarcoma (EPS) remains a largely unmet clinical need in children, adolescents and young adults despite the advent of EZH2 inhibitor tazemetostat.

Methods: In order to realise consistently effective drug therapies, a functional genomics approach was used to identify key signalling pathway vulnerabilities in a spectrum of EPS patient samples. EPS biopsies/surgical resections and cell lines were studied by next-generation DNA exome and RNA deep sequencing, then EPS cell cultures were tested against a panel of chemical probes to discover signalling pathway targets with the most significant contributions to EPS tumour cell maintenance.

Results: Other biologically inspired functional …

2022 July - Tennessee Monthly Climate Report, Tennessee Climate Office, East Tennessee State University

Tennessee Climate Office Monthly Reports

No abstract provided.

2022/2023 University Of The Pacific General Catalog, University Of The Pacific

Catalogue, Bulletin, Catalog

No abstract provided.

Red Flags And Risks: Unpleasant Surprises When An Office Manager Suddenly Leaves, David Harris Cpa

The Journal of the Michigan Dental Association

Losing an office manager can pose significant challenges for dental practices. This article delves into the red flags and potential risks that may accompany an office manager's sudden departure, shedding light on the importance of understanding the circumstances surrounding their exit. The article highlights how embezzlement can be a reason behind unexplained departures and emphasizes the need to assess the situation more deeply. It explores account ownership issues that can hinder practice owners from accessing crucial business information, particularly in embezzlement investigations. The article recommends proactive measures for practice owners to secure access to vital accounts to prevent potential issues …

Schooling Black Males: Hegemonic Discourses, Structural Barriers, And Strategic Resistance, Cleo Wadley

Electronic Theses and Dissertations

Black males have scored at the lowest levels of academic achievement compared to other racial groups in many Texas school districts. The achievement gap for this population of students has been explained by both material constraints and oppressive hegemonic discourses. The purpose of this qualitative research study was to understand how such barriers and discourses affected these students and how the students negotiated their experiences in school. This study was designed to describe the problem, its background and to discuss a relevant theoretical framework. This study examined the academic achievement data for Black males and the current literature on adverse …

A Hawaiian Heroine’S Journey: The Early Life And Career Of Dancer Jean Erdman Campbell, Diane B. Mcghee

Theses and Dissertations

This biographical study covers the early life and career of dancer, choreographer, and avant-garde theatre artist, Jean Erdman Campbell (1916-2020). Based on extensive research of historical literature and archival materials, the manuscript traces Erdman’s ancestry and follows the subject through age 32, when she became established as a star of modern dance and prepared for a world tour. The guiding question for this study was what influences shaped the life course, identity and artistry of Erdman, and how might the subject be presented as biography? The researcher examined the influences on Erdman as related to various dance traditions, especially Hawaiian …

Volume 31, Number 2, Summer 2022, Office Of Communications, Illinois Wesleyan University

Illinois Wesleyan University Magazine, 2018-present

VOLUME 31 | NUMBER 2 | Summer 2022

ON OUR COVER: Dr. Nurman Noor ’08 showcased his culinary skills as an eventual runner-up in The Great Australian Bake Off. Photo courtesy of Foxtel Publicity.

14 Baked with Love Dr. Nurman Noor ’08 may be a general practitioner by trade, but a passion for baking earned him a spot in the TV series The Great Australian Bake Off, where he won scores of fans with his likable personality, raw vulnerability and mouth-watering creations.

18 Breaking Through Angela (Tomazin) Hesemann ’09 found herself laid off at the outset of the COVID-19 pandemic, …

Sex Differences And Potential Non-Invasive Treatments For Calcific Aortic Valve Disease, Henry Pascal Helms

Theses and Dissertations

Calcific Aortic Valve Disease (CAVD) is a progressive heart disease that ranges from aortic valve sclerosis to aortic valve stenosis. It is characterized by intense calcification and compromised valve function. CAVD affects 25% of people older than 65 and 50% of people older than 85. These rates are expected to increase in the United States due to higher levels of obesity and diabetes, as well as an aging population. CAVD is the leading cause of valve replacement surgery. Annual healthcare costs for these valve replacements are currently estimated to be approximately 2 billion dollars. There are currently no medications approved …

Healthy Aging Beyond Sex And Gender Binaries, Nicole M. Lampe

Theses and Dissertations

An estimated 2.7 million sexual and gender minority (SGM) adults 50+ reside in the United States (US) with this number projected to increase to more than 5 million by 2060 (Flatt et al. 2022; Fredriksen-Goldsen and Kim 2017). Medical research, education, and practice in the United States (US) often erase sex and gender variation, thus ignoring the experiences of older adults living beyond Western sex and gender binary systems (e.g., female/male and women/men), particularly transgender, non-binary, and/or intersex (TNBI) populations. Such erasure stems from TNBI older adult structural incompetency or the failure to understand how macro-level systems, institutions, and structures …

Mechanisms Of Connectivity In Neuronal Development, Janay Vacharasin

Theses and Dissertations

The development of neuronal connectivity requires the careful orchestration of multiple cellular processes including the control of neuronal arborization and synapse formation or function. Defects in these processes during neuronal development will give rise to disorders of neuronal connectivity like autism. In the present work, we examine the genetic and epigenetic mechanisms that build the neuronal wiring of the developing brain. We use human stem cell-derived neurons to study neuronal arborization and function focusing on genetic and environmental risk factors of neurodevelopmental disorders that include autism and intellectual disability. Specifically, we focused on the contribution of the endomembrane, chromatin, and …

The Devil And Tom Robot: The Use Of Robotics To Impact Empathy In Secondary Students Of American Literature, Susan K. Porter-Voss

Theses and Dissertations

The purpose of this action research study was to evaluate the effect of a robotics-based intervention on empathy for students enrolled in secondary English and literature courses. Empathy, as a concept, is an integral component of reading comprehension and student motivation. A decline in reported individual levels of empathy among young adults can negatively influence longitudinal academic and career success. Robotics present a promising method in which to impact student learning in K-12 environments. Student manipulation of Wonder Workshop Cue robots in designed challenges was integrated within literature content standards for English III. The outlined study measured the impact of …

A Finding Place: Social Justice Poetry Toward Empathy In The Secondary English Language Arts Classroom, Patricia Vicino

Theses and Dissertations

This study examined the effects of a combined reader-response and close reading approach to social justice poetry on the empathy levels of secondary level English Language Arts students in my classroom. This action research study occurred over a six-week period during a Fall 2021 English elective course with six student participants in a high school within South Carolina. Research was conducted via a mixed methods approach that analyzed both quantitative and qualitative data from prestudy and poststudy Likert scales along with surveys, interviews, observation notes, and artifacts. The data revealed that student empathy levels were elevated after the study unit …

Using Multimedia Vocabulary Games To Improve Newcomer Esol Students Motivation And Vocabulary Acquisition, Elizabeth E. Brittingham

Theses and Dissertations

This study looks at the use of the multimedia learning platform, Quizlet, to help newcomer ESOL students learn English vocabulary. The use of Quizlet to learn vocabulary is supported by Mayer’s Cognitive Load Theory. With an influx of ESOL students, and a lack of teacher training, Quizlet may help to create a more equitable solution for newcomer ESOL students to learn English vocabulary. The findings of this study show that newcomers benefit from using Quizlet to learn vocabulary in the language 2 by matching it to the vocabulary in the language 1, but only if they are able to read …

Mechanisms And Impact Of Hypoxia Regulated Inhibins In Cancer, Ben Allen Horst

Theses and Dissertations

Inhibins are heterodimeric ligands within the TGFβ superfamily, comprised of an α-subunit (INHA) and a β-subunit (either INHBA or INHBB) with emergent roles in cancer. Inhibins are biomarkers of disease burden and prognosis in a subset of cancers and utilize the coreceptors betaglycan (TGFBR3) and endoglin (ENG) for physiological or pathological outcomes. Previously, we found inhibin promotes angiogenesis in ovarian cancer however no mechanism of regulation for inhibin expression in cancer has been established. Hypoxia, a driver of tumor growth and metastasis, regulates angiogenic pathways that are targets for vessel normalization and ovarian cancer management. …

Examining The Relationship Between School Policing Behaviors And The Depressive Symptoms Experienced By Black Students, Collin Perryman

Theses and Dissertations

The school policing literature has two major themes: (a) the negative safety outcomes of school safety (Gottfredson et al., 2020) and (b) the central role that school police play in placing Black students into the school-to-prison-nexus (Morris, 2016; Turner & Beneke, 2020). The study of school police roles, how school police interact with educators, and the safety effects of school police presence is important. Just as important is knowing the mental health effects of physical and nonphysical school policing behaviors on Black students. This dissertation sought to fill this gap in part by studying the relationship between school police behaviors …

A Performance Guide To “Four Piano Pieces, Opus 1” By Evgeny Kissin, Andrew Choi

Theses and Dissertations

This document provides a performance guide to Evgeny Kissin’s Four Piano Pieces, Opus 1. Although more musicians are becoming familiar with his compositions, there are no comprehensive scholarly resources available about this work. This document aims to provide that needed resource.

Evgeny Igorevich Kissin (b.1971) is a Russian-born internationally acclaimed pianist. He achieved stardom with a performance featuring the two piano concerti by Frederic Chopin in 1984. The event was recorded live and released as an album by RCA Victor. Since then, he has been in constant demand all over the world. Although he mainly performs, he occasionally composes as …

In Vivo And In Vitro Investigations Of Mammalian Stem Cell Development: Neurogenesis And Pituitary Progenitors, Allison Culver

Theses and Dissertations

Human development is tightly regulated by complex mechanisms to pattern the early embryo and form specialized tissues. Understanding this regulation is of fundamental importance and can help further understand disease pathologies. Because it is difficult to observe the processes of interest, researchers must rely on the use of model systems. Our research goal is to combine both animal models and in vitro stem cell cultures to address key questions about the mechanisms of development for both the pituitary gland and brain. It is estimated that there are 290-455 cases per million of congenital hypopituitarism. In addition, autism spectrum disorder (ASD) …

The Impact Of Steam-Flaked Rye Replacing Steam-Flaked Corn On Performance And Carcass Characteristics Of Yearling Steers And The Effect Of Exogenous Megasphaera Elsdenii Administration Techniques On Ruminal Fermentation And Blood Parameters In An Acidosis Challenge Model, Samantha K. Wagner

Department of Animal Science: Dissertations, Theses, and Student Research

A feedlot study was conducted to evaluate the effects of replacing steam-flaked corn (SFC) with steam-flaked rye (SFR) in the diets of yearling steers (Exp. 1). A separate study was conducted to evaluate the effects of three different administration techniques of Megasphaera elsdenii NCIMB 41125 on rumen fermentation and blood parameters in an acidosis challenge model (Exp. 2). In Exp. 1, SFC was replaced with SFR to create four different treatments, each differing in the ratio of SFC:SFR. The four treatments were 0:100, 25:75, 50:50, and 100:0 SFR:SFC (as a percentage of the grain inclusion). Increasing inclusions of SFR resulted …

Dividing The Blue Line: The Cultural Work Of Rural Policing In Upstate New York, Michael Branch

Dissertations - ALL

This dissertation focuses on the ways in which residents of Old Forge, New York make use of policing as a resource to structure and reproduce social and symbolic boundaries. Drawing on in-depth interviews with a combination of 40 permanent residents and second-home owners in the area, I explore how policing in this rural amenity-based tourist town is rooted in the economic and social histories of the area and how it structures access to social and moral capital for residents. I focus on how social divisions between permanent residents and second-home owners are observed and experienced by both groups and how …

Catastrophic Christianity: An Iconological Study Of The Messianic Idea In American Protestant Christianity Circa 1900-1940, Adam D. J. Brett

Dissertations - ALL

A historically variegated emblem of trust and faith, the messianic idea is the offer of religion to the people for salvation from the coming catastrophe. This dissertation analyzes the messianic idea in "America." The foci of the study are popular messianic figurations that serve as heuristic devices to explicate early 20th century U.S. culture, revealing two ideological impulses that encapsulate collective responses to the anxieties of the age: authoritarian-populism and catastrophic-utopianism. Four case studies, encompassing four different genres of media, define and illustrate these ideological impulses: The Fundamentals, Superman comic books, Bruce Barton's capitalist Christianity, and The Wizard of Oz …

Saving This Honorable Court: Supreme Court Legitimacy And Support For Court Reform, Nathan Thomas Carrington

Dissertations - ALL

For the first time in nearly a century, serious conversations are taking place involving re- form of the Nation's highest court. Scholarly wisdom holds that such discussions indicate a decrease of the Court's legitimacy which will have detrimental effects on the rule of law and minority rights. Indeed, several generations of political science scholarship have exam- ined the relationship between institutional support for the Supreme Court and its ability to exercise judicial power effectively, all finding a strong relationship. Do reform efforts actu- ally signal a collapse in Court legitimacy and the death of the rule of law as we …

Adversarial Activity Detection And Prediction Using Behavioral Biometrics, Amin Fallahi

Dissertations - ALL

Behavioral biometrics can be used in different security applications like authentication, identification, etc. One of the trending applications is predicting future activities of people and guessing whether they will engage in malicious activities in the future. In this research, we study the possibility of predicting future activities and propose novel methods for near-future activity prediction.

First, we study gait signals captured using smartphone accelerometer sensor and build a model to predict a future gait signal. Activity recognition using body movements captured from mobile phone sensors has been a major point of interest in recent research. Data that is being continuously …

Evaluation Of The Energetic Factors In Crystalline Pharmaceuticals Using Solid-State Density Functional Theory And Low-Frequency Vibrational Spectroscopy, Margaret P. Davis

Dissertations - ALL

Due to the importance of maintaining stable and effective pharmaceutical solid doses, it is critical to study the variety of solid forms that active pharmaceutical ingredients can adopt including polymorphs, hydrates, and cocrystals. In this work, low-frequency vibrational spectroscopies and rigorous quantum mechanical simulations are combined to provide a new technique for characterizing and investigating pharmaceutically relevant polymorphs, hydrates, and cocrystals as well as a series of model cocrystals. Low-frequency spectra in the sub-200 cm-1 range provide not only unique and characteristic spectra for all of the systems explored here but, along with X-ray structural parameters, they offer a way …