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Exploring Human Aging Proteins Based On Deep Autoencoders And K-Means Clustering, Sondos M. Hammad, Mohamed Talaat Saidahmed, Elsayed A. Sallam, Reda Elbasiony Mar 2024

Exploring Human Aging Proteins Based On Deep Autoencoders And K-Means Clustering, Sondos M. Hammad, Mohamed Talaat Saidahmed, Elsayed A. Sallam, Reda Elbasiony

Journal of Engineering Research

Aging significantly affects human health and the overall economy, yet understanding of the underlying molecular mechanisms remains limited. Among all human genes, almost three hundred and five have been linked to human aging. While certain subsets of these genes or specific aging-related genes have been extensively studied. There has been a lack of comprehensive examination encompassing the entire set of aging-related genes. Here, the main objective is to overcome understanding based on an innovative approach that combines the capabilities of deep learning. Particularly using One-Dimensional Deep AutoEncoder (1D-DAE). Followed by the K-means clustering technique as a means of unsupervised learning. …

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The Role Of Greenways In Achieving Urban Sustainability For Cities Accordance With The Sustainable Development Goals 2030, Walaa Ahmed Nour Prof, Aya Abdelazim Abdeen, Lobna Agha Prof Mar 2024

The Role Of Greenways In Achieving Urban Sustainability For Cities Accordance With The Sustainable Development Goals 2030, Walaa Ahmed Nour Prof, Aya Abdelazim Abdeen, Lobna Agha Prof

Journal of Engineering Research

The concept of "greenways" emerged to achieve sustainable development in urban areas and to address natural disasters resulting from climate change. This research paper aims to study the role of greenways in achieving urban sustainability and their facilitation in achieving the Sustainable Development Goals for 2030. The paper expounds on the idea and origin of greenways, their benefits, and analyzes some global examples. Furthermore, it categorizes the indicators of greenway design into two types: those with a positive impact and those without an impact on sustainable development goals. Using standardized tools, the relationship between each indicator and sustainable development goals …

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Amethod To Estimate Climate Drivers Ofmaize Yield Predictability Leveraging Genetic-By-Environment Interactions In The Us And Canada, Parisa Sarzaeim, Francisco Munoz-Arriola Mar 2024

Amethod To Estimate Climate Drivers Ofmaize Yield Predictability Leveraging Genetic-By-Environment Interactions In The Us And Canada, Parisa Sarzaeim, Francisco Munoz-Arriola

School of Natural Resources: Faculty Publications

Throughout history, the pursuit of diagnosing and predicting crop yields has evidenced genetics, environment, and management practices intertwined in achieving food security. However, the sensitivity of crop phenotypes and genetic responses to climate still hampers the identification of the underlying abilities of plants to adapt to climate change. We hypothesize that the PiAnosi and WagNer (PAWN) global sensitivity analysis (GSA) coupled with a genetic by environment (GxE) model built of environmental covariance and genetic markers structures, can evidence the contributions of climate on the predictability of maize yields in the U.S. and Ontario, Canada. The GSA-GxE framework estimates the relative …

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Micrornas In Pancreatic Cancer: Advances In Biomarker Discovery And Therapeutic Implications, Roland Madadjim, Thuy An, Juan Cui Mar 2024

Micrornas In Pancreatic Cancer: Advances In Biomarker Discovery And Therapeutic Implications, Roland Madadjim, Thuy An, Juan Cui

School of Computing: Faculty Publications

Pancreatic cancer remains a formidable malignancy characterized by high mortality rates, primarily attributable to late-stage diagnosis and a dearth of effective therapeutic interventions. The identification of reliable biomarkers holds paramount importance in enhancing early detection, prognostic evaluation, and targeted treatment modalities. Small non-coding RNAs, particularly microRNAs, have emerged as promising candidates for pancreatic cancer biomarkers in recent years. In this review, we delve into the evolving role of cellular and circulating miRNAs, including exosomal miRNAs, in the diagnosis, prognosis, and therapeutic targeting of pancreatic cancer. Drawing upon the latest research advancements in omics data-driven biomarker discovery, we also perform a …

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Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office Mar 2024

Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office

University Budget Office records

No abstract provided.

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Climate Change-Associated Declines In Water Clarity Impair Feeding By Common Loons, Walter H. Piper, Max R. Glines, Kevin C. Rose Mar 2024

Climate Change-Associated Declines In Water Clarity Impair Feeding By Common Loons, Walter H. Piper, Max R. Glines, Kevin C. Rose

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Climate change has myriad impacts on ecosystems, but the mechanisms by which it affects individual species can be difficult to pinpoint. One strategy to discover such mechanisms is to identify a specific ecological factor related to survival or reproduction and determine how that factor is affected by climate. Here we used Landsat imagery to calculate water clarity for 127 lakes in northern Wisconsin from 1995 to 2021 and thus investigate the effect of clarity on the body condition of an aquatic visual predator, the common loon (Gavia immer). In addition, we examined rainfall and temperature as potential predictors …

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A Comparison Of Learning Outcome On Course Life And Environment By Problem Base Learning And Case Study Base Learning, Pudthachad Tongkhott Mar 2024

A Comparison Of Learning Outcome On Course Life And Environment By Problem Base Learning And Case Study Base Learning, Pudthachad Tongkhott

Journal of Education Studies

The purposes of this research were to compare learning outcome, to explore scientific attitude and to learn inquiry skill on course life and environment by using 2 learning methods which were Problem Based Learning and Case Based Learning. The research samples were 90 bachelor students studying at a government university. They were selected through purposive sampling method. The instruments used in this research were the learning outcome test, the scientific attitude test, and the inquiry skill test. The data were analyzed using an arithmetic mean, standard deviation, and t-test. The research findings could be concluded as follows: 1) The …

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Online Student-Centered Learning And Assessment During The Covid-19 Pandemic Through Perspectives Of Higher Education Teachers And Students, Nuttaporn Lawthong, Purin Thepsathit, Chanut Poondej, Thanita Lerdpornkulrat, Ittipaat Suwathanpornkul Mar 2024

Online Student-Centered Learning And Assessment During The Covid-19 Pandemic Through Perspectives Of Higher Education Teachers And Students, Nuttaporn Lawthong, Purin Thepsathit, Chanut Poondej, Thanita Lerdpornkulrat, Ittipaat Suwathanpornkul

Journal of Education Studies

This study aimed to 1) analyze student-centered learning and assessment of higher education teachers and students during the COVID-19 pandemic as well as their ability to meet learning objectives, and 2) compare the online learning efficiency of students with four psychological attributes, consisting of student-teacher engagement, online learning characteristics, self-directed learning, and self-assessment. The sample included 1,409 university students and 274 teachers. The research instrument was a student-centered online learning and assessment scale. Data were analyzed via descriptive statistics and a chi-squared test. The results revealed that the sample struggled with unstable Internet or WIFI connection, a lack of technological …

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A Study Of Learning Management Conditions In Technology To Enhance The Creative Thinking Ability Of Students With A Hearing Impairment, Phanat Nakboon, Anucha Phoommisittiporn, Sukkaew Comesorn Mar 2024

A Study Of Learning Management Conditions In Technology To Enhance The Creative Thinking Ability Of Students With A Hearing Impairment, Phanat Nakboon, Anucha Phoommisittiporn, Sukkaew Comesorn

Journal of Education Studies

The purpose of this study was to study the problems and needs of learning management conditions in enhancing creative thinking among students with a hearing impairment. The study only included ninety-nine participants of the eleven schools in school for the deaf that used multi-stage sampling, including both specific and purposive sampling. The main instrument used was the questionnaire on the learning management conditions and data were analyzed and presented using frequency analysis, percentage, mean, and standard deviation. The results of this study indicated that the learning management conditions to enhance creative thinking among hearing impaired students are as follows: the …

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Development Of A Bcg Economy Model-Integrated Stem Learning Activities, Tharuesean Prasoplarb, Jirapa Pootawee, Kornkanok Lertdechapat Mar 2024

Development Of A Bcg Economy Model-Integrated Stem Learning Activities, Tharuesean Prasoplarb, Jirapa Pootawee, Kornkanok Lertdechapat

Journal of Education Studies

BCG economy model-integrated STEM education has been widely promoted as a significant driver of Thai education, with its three dimensions of bioeconomy, circular economy, and green economy serving as the main features of integrated STEM activities in promoting learners’ competencies. This academic article provides a model for BCG economy model-integrated STEM learning activities centered around the theme “The Right Cup! for Valentine’s Day”. The purpose of this BCG model-integrated activity was to create the formulation of a drink which was made from local ingredients. The seven steps of BCG economy model-integrated STEM learning activities include: 1) identifying the problem; 2) …

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Interactive Effects Of Co2, Temperature, And Nitrate Limitation On The Growth And Physiology Of Marine Cyanobacterium Synechococcus Sp. Ccmp 1334, Alyssa K. Sharbaugh Mar 2024

Interactive Effects Of Co2, Temperature, And Nitrate Limitation On The Growth And Physiology Of Marine Cyanobacterium Synechococcus Sp. Ccmp 1334, Alyssa K. Sharbaugh

LSU Master's Theses

The marine cyanobacterium Synechococcus sp. CCMP 1334 was grown in a continuous culture system on a 12:12 h light:dark cycle at all combinations of low and high pCO2 (400 and 1000 ppmv, respectively), nitrate availability (nitrate-limited and nutrient-replete conditions), and temperatures of 21°C, 24°C, 28°C, 32°C, and 35°C. The maximum median nutrient-replete growth rate was ~1.15 d−1 at 32 –35°C. Median growth rates at 1000 ppmv pCO2 were higher than those at 400 ppmv at all temperatures, but most of the differences were statistically insignificant. Carbon:nitrogen ratios were independent of pCO2 at a fixed relative growth rate but decreased with …

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Covid-19 Cases And Factors Associated With 11 Indonesian Provinces, 2021, Mugi Wahidin, Wawan Ridwan, Doni Lasut, Aan Kurniawan, Yurika Fauzia Wardhani Mar 2024

Covid-19 Cases And Factors Associated With 11 Indonesian Provinces, 2021, Mugi Wahidin, Wawan Ridwan, Doni Lasut, Aan Kurniawan, Yurika Fauzia Wardhani

Media Kesehatan Masyarakat Indonesia

In collaboration with other stakeholders, National Task Force of COVID-19 Control conducted massive detection of the cases, followed by contact tracing. The study aimed to overview COVID-19 cases from 58 districts of 11 provinces in Indonesia and its associated factors. A cross-sectional study design used secondary data from The National Task Force of COVID-19 Control. COVID-19 cases and other variables were collected in 58 districts in 11 provinces of Indonesia year 2021. The study incorporated descriptive, correlation, and multiple linear regression analysis with the district as an analysis unit. The median of COVID-19 cases was 804 per district, traced cases …

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Auditory Vigilance Decrement In Drivers Of A Partially Automated Vehicle: A Pilot Study Using A High-Fidelity Driving Simulator, Luca Brooks, Jeffrey Glassman, Yusuke Yamani Mar 2024

Auditory Vigilance Decrement In Drivers Of A Partially Automated Vehicle: A Pilot Study Using A High-Fidelity Driving Simulator, Luca Brooks, Jeffrey Glassman, Yusuke Yamani

Undergraduate Research Symposium

Vigilance decrement is the decline in the ability to monitor and detect behaviorally important signals over time, a phenomenon that can arise even after 30 minutes of watch (Mackworth, 1948). Recently, McCarley & Yamani (2021) found bias shifts, sensitivity losses, and attentional lapses contribute to vigilance decrement, but when each effect is isolated, there was little evidence that sensitivity loss affected vigilance decrement. With the introduction of partially autonomous vehicles, vigilance decrement may be problematic for drivers who must monitor the autonomous system for failures and takeover requests. Thus, this pilot study aims to extend McCarley and Yamani (2021) and …

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Generating A Design Automation For Functional Relationship In Residential Building: Developing Plug In, Fatima Yahya Belok, Mostafa Khalifa, Nabil Mohareb Mar 2024

Generating A Design Automation For Functional Relationship In Residential Building: Developing Plug In, Fatima Yahya Belok, Mostafa Khalifa, Nabil Mohareb

Architecture and Planning Journal (APJ)

Designers, architects, and students face many problems in finding the optimum zoning or exploring different alternatives during early design stages, which consumes time and energy. To solve this problem, a computer editing tool will be an added value that helps users at this stage. The optimization of functional relationship is very important as many factors should be considered such as orientation; vertical and horizontal relationship; areas, view, building regulations, opening to wall ratio, form-to-form relationship, spaces proportions, circulation, and other related issues. In computer generative design, recent research has reached a goal to generate functional relationship in residential buildings and …

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Exploring Spatial Configuration For Effective Way-Finding In The Design Of Shopping Malls In Abuja - Nigeria, Jephthah I. Aigbe, Joy J. Maina, Musa L. Sagada Mar 2024

Exploring Spatial Configuration For Effective Way-Finding In The Design Of Shopping Malls In Abuja - Nigeria, Jephthah I. Aigbe, Joy J. Maina, Musa L. Sagada

Architecture and Planning Journal (APJ)

Shopping malls are an integral feature of the urban environment. Abuja is one of the fastest growing cities in Africa. With its thriving population, it has become a hub of urban activities. The presence of shopping complexes within the city is on a steady increase. Wayfinding is an activity that every shopper must engage in. The need for more wayfinding research in the Nigerian context is evident. A study was carried to explore spatial organization for effective wayfinding in shopping malls. Case study was carried out on three shopping malls in Abuja using a visual survey, questionnaire survey and Visibility …

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Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami Mar 2024

Improving Educational Delivery And Content In Juvenile Detention Centers, Yomna Elmousalami

Undergraduate Research Symposium

Students in juvenile detention centers have the greatest need to receive improvements in educational delivery and content; however, they are one of the “truly disadvantaged” populations in terms of receiving those improvements. This work presents a qualitative data analysis based on a focus group meeting with stakeholders at a local Juvenile Detention Center. The current educational system in juvenile detention centers is based on paper worksheets, single-room style teaching methods, outdated technology, and a shortage of textbooks and teachers. In addition, detained students typically have behavioral challenges that are deemed "undesired" in society. As a result, many students miss classes …

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Field Testing Of Gamma-Spectroscopy Method For Soil Water Content Estimation In An Agricultural Field, Sophia Becker, Trenton E. Franz, Tanessa Morris, Bailey Mullins Mar 2024

Field Testing Of Gamma-Spectroscopy Method For Soil Water Content Estimation In An Agricultural Field, Sophia Becker, Trenton E. Franz, Tanessa Morris, Bailey Mullins

School of Natural Resources: Faculty Publications

Gamma-ray spectroscopy (GRS) enables continuous estimation of soil water content (SWC) at the subfield scale with a noninvasive sensor. Hydrological applications, including hyper-resolution land surface models and precision agricultural decision making, could benefit greatly from such SWC information, but a gap exists between established theory and accurate estimation of SWC from GRS in the field. In response, we conducted a robust three-year field validation study at a wellinstrumented agricultural site in Nebraska, United States. The study involved 27 gravimetric water content sampling campaigns in maize and soybean and 40K specific activity (Bq kg−1) measurements from a stationary …

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Insights Derived In Silico On The Nature Of The Halogen · · · Halogen Bond At Ordered Surface Interfaces, Jarrod George Sage Mar 2024

Insights Derived In Silico On The Nature Of The Halogen · · · Halogen Bond At Ordered Surface Interfaces, Jarrod George Sage

Theses and Dissertations

Halogen· · · halogen (X· · ·X) bonds are a poorly understood, special class of non-covalent contact known to profoundly impact processes of molecular self-assembly, such as crystal formationand thin-layer epitaxy. The study of X· · ·X bonding on surfaces is well established, but it is unclear exactly to what extent a surface influences X· · ·X contacts or their dynamics. Simulations of X· · ·X bonding at ordered surfaces via plane-wave density functional theory (DFT) occasionally arise to compliment experimental results, but there is yet to be a comprehensive in silico exploration probing the nature of the X· · …

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Convergence Or Divergence? An Exploratory Study On Urban Malays And Indigenous People In Kuala Lumpur And Kuching, Syaza Farhana Mohamad Shukri, Mohd Shazani Masri Mar 2024

Convergence Or Divergence? An Exploratory Study On Urban Malays And Indigenous People In Kuala Lumpur And Kuching, Syaza Farhana Mohamad Shukri, Mohd Shazani Masri

Asia-Pacific Social Science Review

Malaysia has been celebrated as a diverse nation since 1963. However, interethnic relations remain difficult as distrust appears to continue between the majority Malays and minority groups. This is the common narrative in Peninsular Malaysia. In East Malaysia, there is no clear ethnic majority population, which is also the case in Sarawak. Although the government has usually grouped together the Malays and indigenous people for nation-building purposes, it must be noted that the different backgrounds create a heterogeneous “majority” in Malaysia. This diversity may even explain the different views among the Malays in Kuala Lumpur and in Kuching, Sarawak regarding …

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Proposed Educational Curriculum Using The Teaching Stations Strategy To Learn Some Defensive Skills In Handball, Asmaa Aziz Faleh Mar 2024

Proposed Educational Curriculum Using The Teaching Stations Strategy To Learn Some Defensive Skills In Handball, Asmaa Aziz Faleh

Modern Sport

The current research aims to investigate the impact of a proposed educational curriculum using the teaching stations strategy on learning some defensive skills in handball among third-stage students, Department of Physical Education, College of Basic Education. The problem of the research lies in the fact that handball is a team sport characterized by its various and interconnected skills. The researcher found a variation in the skill performance level of defensive skills in handball. If the players cannot perform the defensive skills effectively, it will affect their level and, consequently, weaken the defensive aspect among the students. Therefore, it is essential …

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Perceived Over-Qualifications Of Volleyball Players And Their Relationship With Communication Skills With Team Members In The Clubs Of The Northern Region Of Iraq, Majeed Hameed Aziz, Majeed Hameed Fahed Mar 2024

Perceived Over-Qualifications Of Volleyball Players And Their Relationship With Communication Skills With Team Members In The Clubs Of The Northern Region Of Iraq, Majeed Hameed Aziz, Majeed Hameed Fahed

Modern Sport

The research aimed to identify the level of perceived over-qualifications among volleyball players in clubs in the northern region of Iraq from their perspective, and their communicative abilities, with an explanation of the type and nature of the relationship between the perceived over-qualifications and communicative abilities. The researchers used the descriptive method in both its survey and correlational styles. The researchers defined the study population as volleyball players in the active clubs of the northern region's premier league and first division, totaling (27) clubs across four provinces: Kirkuk, Nineveh, Diyala, and Salahuddin. The researchers chose the entire study population as …

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Can Argument-Driven Inquiry-Assisted Virtual Laboratory Improve Pre-Service Physics Teachers’ Mastery Concept Of Simple Harmonic Oscillation?, Yolanda Dwi Vivian Karawahenni, Sutopo Sutopo, Arif Hidayat, Maya Mustika Mar 2024

Can Argument-Driven Inquiry-Assisted Virtual Laboratory Improve Pre-Service Physics Teachers’ Mastery Concept Of Simple Harmonic Oscillation?, Yolanda Dwi Vivian Karawahenni, Sutopo Sutopo, Arif Hidayat, Maya Mustika

Jurnal Pendidikan Sains

This study endeavors to ascertain the efficacy of the Argument-Driven Inquiry (ADI)- assisted virtual laboratory learning model in enhancing the comprehension of simple harmonic oscillation concepts among pre-service physics teachers. Employing a mixed- method approach with an embedded experimental design, the investigation employs a reasoned multiple-choice instrument comprising 15 questions. Analysis of the results reveals a noteworthy 48.38% increase in the average mastery of concepts between the pre-test and post-test, yielding an N-gain value of 0.63. Statistical scrutiny through paired sample t-tests corroborates significant disparities between pre-test and post-test scores, evidenced by a tcount (16.28) exceeding the critical ttable value …

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Error Analysis Of Learners’ Problem-Solving Abilities In Mathematics Courses: A Newman Error Analysis (Nea) Approach, Aprilita Ekasari, Don Jaya Putra Mar 2024

Error Analysis Of Learners’ Problem-Solving Abilities In Mathematics Courses: A Newman Error Analysis (Nea) Approach, Aprilita Ekasari, Don Jaya Putra

Jurnal Pendidikan Sains

This study endeavors to systematically discern the spectrum of learner errors manifesting in problem-solving processes within the domain of mathematics, specifically focusing on the intricacies of integration, utilizing Newman Error Analysis (NEA) as the guiding framework. The cohort under investigation comprises 14 first-year students hailing from the Department of Physics Education at Musamus University, Merauke. Employing a descriptive methodology underscored by a qualitative orientation, this research incorporates tests and interviews as primary instruments for data collection. The tests are designed to meticulously evaluate the array of errors committed by learners, as per the tenets of Newman’s model. Additionally, a subset …

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Fostering Engagement And Learning Outcomes: A Comparative Analysis Of Ethnochemical And Stem-Based Pedagogies For Chemistry Learning In Vocational High Schools, Maulidya Husnul Khatimah, Lismi Animatul Chisbiyah Mar 2024

Fostering Engagement And Learning Outcomes: A Comparative Analysis Of Ethnochemical And Stem-Based Pedagogies For Chemistry Learning In Vocational High Schools, Maulidya Husnul Khatimah, Lismi Animatul Chisbiyah

Jurnal Pendidikan Sains

In contemporary education, the perceived difficulty of learning chemistry, attributed to its abstract nature, remains a challenge for many students. This difficulty is compounded by a notable lack of alignment between chemistry concepts and students’ daily experiences, despite the inherent relevance of chemistry to their everyday phenomena. Building on previous research affirming the efficacy of ethnochemical modules in enhancing student learning and achievement, this study investigates the suitability of a STEM-based approach for chemistry education, particularly in vocational high school. The research methodology employs a literature study method, utilizing the PICO(T) framework for keyword selection. A rigorous review and analysis …

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Differences In Biology Students’ Self-Regulation During Online And Offline Learning And Its Relationship To Learning Outcomes, Adi Kus Rochman Jk, Dwi Listyorini, Fatchur Rohman, Yessi Affriyenni Mar 2024

Differences In Biology Students’ Self-Regulation During Online And Offline Learning And Its Relationship To Learning Outcomes, Adi Kus Rochman Jk, Dwi Listyorini, Fatchur Rohman, Yessi Affriyenni

Jurnal Pendidikan Sains

The cultivation of self-regulatory skills holds paramount importance for individuals’ future success, particularly in the context of evolving educational modalities prompted by the Covid-19 pandemic. As learning transitions between online during the pandemic and offline post-pandemic, understanding the nuances of self-regulation becomes imperative. Thus, this study sought to achieve three objectives: (1) analyzing disparities in student self-regulation between online and offline settings, (2) examining the interplay between online and offline self-regulation, and (3) scrutinizing the relationship between self-regulation and learning outcomes. Employing a methodological approach involving questionnaire administration, interviews, and collecting academic scores data, data analysis was conducted utilizing the …

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An Exploration Of Secondary School Science Teacher’S Epistemological Belief In Malang, Anindyta Nur Rizkyana Safitri, Endang Purwaningsih, Nuril Munfaridah, Alif Darmawan Mar 2024

An Exploration Of Secondary School Science Teacher’S Epistemological Belief In Malang, Anindyta Nur Rizkyana Safitri, Endang Purwaningsih, Nuril Munfaridah, Alif Darmawan

Jurnal Pendidikan Sains

The objective of this study is to delve into the epistemological convictions of secondary school science teachers in Malang across various tenures, namely senior teachers, junior teachers, and pre-service teachers. Employing an explanatory sequential design model, the research employs a mixed-method approach. Quantitative data, gathered through the administration of the Scientific Epistemology Beliefs Questionnaire (n = 30), are complemented by qualitative insights drawn from interviews with teachers (n = 6) concerning their epistemological orientations. Descriptive statistics and qualitative analyses, utilizing an a priori coding technique aligned with the study’s conceptual framework, were conducted on the interview data. Quantitative analysis reveals …

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Myeloid-Derived Suppressor Cell Mitochondrial Fitness Governs Chemotherapeutic Efficacy In Hematologic Malignancies, Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. Macdonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M Fan, Jianmin Wang, Philip L. Mccarthy, Elizabeth A. Repasky, Hemn Mohammadpour Mar 2024

Myeloid-Derived Suppressor Cell Mitochondrial Fitness Governs Chemotherapeutic Efficacy In Hematologic Malignancies, Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. Macdonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W-M Fan, Jianmin Wang, Philip L. Mccarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Markey Cancer Center Faculty Publications

Myeloid derived suppressor cells (MDSCs) are key regulators of immune responses and correlate with poor outcomes in hematologic malignancies. Here, we identify that MDSC mitochondrial fitness controls the efficacy of doxorubicin chemotherapy in a preclinical lymphoma model. Mechanistically, we show that triggering STAT3 signaling via β2-adrenergic receptor (β2-AR) activation leads to improved MDSC function through metabolic reprogram- ing, marked by sustained mitochondrial respiration and higher ATP generation which reduces AMPK signaling, altering energy metabolism. Furthermore, induced STAT3 signaling in MDSCs enhances glutamine consumption via the TCA cycle. Metabolized glutamine generates itaconate which downregulates mitochondrial reactive oxygen species via regulation of …

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Antioxidant Properties Of Bovine Liver Protein Hydrolysates And Their Practical Application In Biphasic Systems, Betul Arslan, Youling L. Xiong, Ayla Soyer Mar 2024

Antioxidant Properties Of Bovine Liver Protein Hydrolysates And Their Practical Application In Biphasic Systems, Betul Arslan, Youling L. Xiong, Ayla Soyer

Animal and Food Sciences Faculty Publications

BACKGROUND: The influence of protein hydrolysate produced from bovine liver protein hydrolysate (LPH) by enzymatic hydrolysis, using Alcalase/Protamex (1:1), on lipid dispersions was investigated. LPH production was optimized to maximize the antioxidant activity (at 45, 50, and 55 °C for 12, 18, and 24 h). Different concentrations of LPHs (1, 3, and 5 mg/g) were added to emulsions and to liposomes. Lipid oxidation level and particle size of the lipid dispersions were monitored for 14 days of storage at 25 °C. RESULTS: Radical scavenging activity and reducing power were the highest at 45 °C after 24 h of hydrolysis. Electrophoresis …

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Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce Mar 2024

Simultaneous Extraction And Quantitative Analysis Of S-Methyl-L-Cysteine Sulfoxide, Sulforaphane And Glucosinolates In Cruciferous Vegetables By Liquid Chromatography Mass Spectrometry, Armaghan Shafaei, Caroline R. Hill, Jonathan M. Hodgson, Lauren C. Blekkenhorst, Mary C. Boyce

Research outputs 2022 to 2026

Sulfur containing compounds including glucosinolates (GLS), sulforaphane (SFN) and S-methyl-L-cysteine sulfoxide (SMCSO) have been proposed to be partly responsible for the beneficial health effects of cruciferous vegetables. As such, greater understanding of their measurements within foods is important to estimate intake in humans and to inform dietary intervention studies. Herein is described a simple and sensitive method for simultaneous analysis of 20 GLS, SFN and SMCSO by liquid chromatography mass spectrometry. Analytes were effectively retained and resolved on an Xbridge C18 column. Detection can be achieved using high resolution or unit resolution mass spectrometry; the latter making the method more …

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أثر الإفصاح عن رأس المال الفكري على قيمة الشركة, محمد ديوان شنيبر الجابري, احمد ناصر عباس الدعمي Mar 2024

أثر الإفصاح عن رأس المال الفكري على قيمة الشركة, محمد ديوان شنيبر الجابري, احمد ناصر عباس الدعمي

Muthanna Journal of Administrative and Economics Sciences

يهدف البحث الى بيان أثر الافصاح عن رأس المال الفكري على قيمة الشركة باستخدام مقياس Tobin’s Q، فضلاً عن بيان آلية حساب مستوى الإفصاح عن رأس المال الفكري باستخدام نماذج حسابية. ولأجل تحقيق اهداف البحث واختبار فرضياته فقد تم اختيار القطاعين الصناعي والمصرفي كمجتمع للبحث، وثلاث شركات من كل قطاع كعيِّنة للبحث وتمثلت الحدود الزمانية للبحث بالاعتماد على التقارير المنشورة لتلك الشركات للأعوام 2018 ، 2019 ، 2020. إذ تم بيان مدى افصاح الشركات عينة البحث عن رأس مالها الفكري عن طريق نماذج حسابية، وقد توصل البحث الى مجموعة من الاستنتاجات وكان أهمها: أن هنالك أثر للإفصاح عن رأس المال …

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