Digital Commons Network^™

Quinolines: Novel Synthesis And Derivatives Of Heterocyclic Bioactive Agents, Ginelle A. Ramann

Electronic Theses and Dissertations

Tuberculosis is a pulmonary disease that has ravaged the world throughout history. Even today, many developed and developing countries are experiencing this plight, made worse by the scourge of antibiotic-resistant bacteria.

Mycobacterium tuberculosis's class II fructose-1,6-bisphosphate aldolase presents an interesting target in the design of new therapies against this disease. Previous attempts to construct an inhibitor to this enzyme fell short due to poor selectivity or poor cellular uptake. However a new class of noncompetitive inhibitor based on 8-hydoxyquinoline-2-carboxylic acid presents a fresh approach. Preliminary studies indicate various modifications to this scaffold could be beneficial to its inhibitory efficacy.

Modifications …

Autonomous Collision Avoidance For A Teleoperated Uav Based On A Super-Ellipsoidal Potential Function, Mohammed Salim Qasim

Electronic Theses and Dissertations

This thesis presents the design of a super-ellipsoidal potential function (SEPF) that can be used, in a static and dynamic environment, for autonomous collision avoidance of an unmanned aerial vehicle (UAV) in a 3-dimensional space. In the design of the SEPF, we have the full control over the shape and size of the potential function. In our proposed approach, a teleoperated UAV can not only autonomously avoid collision with surrounding objects but also track the operator' control input as closely as possible. As a result, an operator can always be in control of the UAV for his/her high-level guidance and …

Crafted Places: The Use Of Place In Wisconsin Craft Beer Marketing, Joseph A. Quintana

Electronic Theses and Dissertations

This research examines place-related themes used in craft beer marketing initiatives in Wisconsin. "Place" describes the emotions and perceptions individuals hold in certain locations. Place theory, despite being universally experienced, is relatively understudied. Furthermore, this project is grounded in the recent neolocal movement - a movement towards local culture, and away from national homogenous culture. Broadly, this paper aims to understand the perceptual linkages between people and "their" place. In order to understand place and neolocal themes within these linkages, this project analyzes how individual beer names, beer-label imagery, and beer-related advertisements use familiar places to link products with a …

Rethinking The "Marginal Revolution" In The History Of Economic Thought: A Brief Examination Of The Marginal Utility Theory Before And In The 1870s, Ding Ning

Electronic Theses and Dissertations

The "Marginal Revolution," a well-known event in the history of economic thought, challenged the mainstream classical political economy and introduced new methods to economic study. The "Marginal Revolution" marked the rise of the Marginal Utility School and pushed the formulation of neoclassical economics. Because marginal utility is the core concept of the "Marginal Revolution," this thesis studies the origin of marginal utility theory by examining figures such as Bernoulli, Bentham, Dupuit, and Goseen, and the utility theory with its related topics of Jevons, Menger and Walras in the 1870s. This thesis considers the significance of the "Marginal Revolution," with particular …

When "I Do" Becomes "I Don't": Exploring Communication Behaviors And Dialectical Tensions In Broken Engagements, Chelsea Annette Hand Stow

Electronic Theses and Dissertations

Communication behaviors and precipitating events were studied in accounts provided by 109 heterosexual individuals living in the United States who had experienced at least one broken premarital engagement. Participants' responses to an exploratory survey designed by the researcher were thematically analyzed in order to determine the causes of broken engagements, communication strategies used in sharing the disengagement narrative, advice given and received, and the presence of relational dialectics (both tensions and coping strategies). Data revealed that broken engagements more closely mirror divorce than dating breakups, engagements are more likely to be broken by women than men, and disengagement more often …

A Comparison Between Propensity Score Matching, Weighting, And Stratification In Multiple Treatment Groups: A Simulation Study, Priyalatha Govindasamy

Electronic Theses and Dissertations

The application of propensity score techniques (matching, stratification, and weighting) with multiple treatment levels are similar to those used in binary groups. However, given that the application of propensity scores in multiple treatment groups is new, factors affecting the performance of matching, stratification, and weighting in multiple treatment groups are less explored. Therefore, this study was conducted to determine the performance of different propensity score techniques with multiple treatment groups under various circumstances. Specifically, the study focused on examining how the three propensity score corrective techniques perform in estimating treatment effects under (1) overt and (2) hidden types of selection …

The Role Of P38 Mapk In Protein Homeostasis And Aging, Sarah Mae Ryan

Electronic Theses and Dissertations

Aging is characterized by a failure to maintain proper protein homeostasis, potentially leading to tissue dysfunction. Though a variety of genes have been found to regulate lifespan and age-related behaviors how these genetic factors contribute to protein homeostasis has not been fully explored. Here, we report that the evolutionarily conserved aging gene p38 MAPK (p38Kb) regulates age-dependent protein homeostasis. Over-expression of p38Kb results in reduced protein aggregation, while knockout of p38Kb leads to increased protein aggregation. Furthermore, we find that p38Kb regulates protein homeostasis, lifespan, and age-dependent locomotor functions through an interaction with the Chaperone Assisted Selective Autophagy complex; a …

The Neuroprotective And Therapeutic Effects Of Anthocyanins And Their Metabolites In Vitro And In A Mouse Model Of Amyotrophic Lateral Sclerosis, Aimee Nicole Winter

Electronic Theses and Dissertations

Anthocyanins, a unique class of flavonoid compounds, have recently come to the forefront of investigative research aimed at evaluating the potential applications of natural products to human health. Evidence demonstrating the beneficial effects of anthocyanin consumption has been reported for a myriad of conditions including cancer, cardiovascular disease, and lately, neurodegenerative disease. Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) are characterized by the death of specific neuronal populations within the brain and spinal cord, leading to cognitive and/or motor impairment. While the etiology of many of these diseases is largely unknown, several factors have …

Professional Development And The Impact On Teacher Growth And Development, Sherry Kathleen Segura

Electronic Theses and Dissertations

This study involved examining the beliefs of teachers at one urban elementary school regarding how professional development has helped them meet the needs of culturally and linguistically diverse students. This study included a series of in-depth interviews with three teacher leaders. The goal was to obtain consent from them to participate in this study at their school. With a qualitative approach, this study included a narrative inquiry method to illuminate teachers' perceptions of whether professional development had a positive impact on their instruction. A series of in-depth one-on-one interviews further shed insight on which types of professional development teachers felt …

Revolutionary Technologies: Praxical Time As A Way Of Overcoming Reification, RóIsíN Lally

Leadership Studies Faculty Scholarship

This article argues that by recognizing the fundamental relationship between praxical time and dwelling as a matrix of interweaving modes of being, society can subvert the potential reification of humanity by technology. This can only be achieved through a democratic process that involves participatory agents not only at the design level but also in the event of naming future innovations. By looking at the work of Alain Badiou, it is shown how a fusion of Heideggerian-inspired phenomenology and speculative ontology is critical for the advancement of social theory, as revolutionary technologies become increasingly immersive.

The Effect Of Soil Erosion On Children’S Calorie Intake Among Corn-Producing Households, Davao Region, Philippines, Pedro A. Alviola Iv, Jon Marx P. Sarmiento, Nikko L. Laorden, Nilo B. Oponda

Journal of Economics, Management and Agricultural Development

Soil erosion is a constant challenge to farm productivity and profitability. However, extending the effect to food expenditure and children’s nutrition is yet to be explored. In this research, an attempt was made to establish the path linking soil erosion to children’s calorie intake levels. Using the geo-coordinates of Mindanao soil erosion areas from the Department of Agriculture-Bureau of Agricultural Research (DA-BAR), Geographic Information System (GIS) was used to identify the research sites for corn producing households in Davao region. A total of 125 samples were analyzed. A 24-hour food-frequency recall survey was conducted and conversion of food consumption to …

Retrograde Tibiopedal Access As A Bail-Out Procedure For Endovascular Intervention Complications, Ahmed Amro, Alaa Gabi, Adee El-Hamdani, Naveed Iqbal, Mehiar El-Hamdani

Cardiology

Introduction. Retrograde pedal access has been well described in the literature as a secondary approach for limb salvage in critical limb ischemia (CLI) patients. In this manuscript we are presenting a case where retrograde tibiopedal access has been used as a bail-out procedure for the management of superficial femoral artery (SFA) intervention complications.

Procedure/Technique. After development of a perforation while trying to cross the totally occluded mid SFA using the conventional CFA access, we were able to cross the mid SFA lesion after accessing the posterior tibial artery in a retrograde fashion and delivered a self-expanding stent which created a …

Estimating China’S Urban Energy Demand And Co2 Emissions: A Bottom-Up Modeling Perspective, N Khanna, D Fridley, L Price, N Zhou, Stephanie Ohshita

Environmental Science

China is experiencing unprecedented urbanization with the urban share of population expected to grow to nearly 80% by 2050. Chinese urban residents consume nearly 1.6 times as much commercial energy as rural residents, and account for an even larger share of energy and carbon dioxide (CO2) emissions embodied in urban infrastructure and goods. As a result, cities can play an increasingly important role in helping China meet its future energy and CO2 intensity reduction targets. While some individual cities have conducted energy and greenhouse gas emission inventories, China lacks estimates of aggregate urban energy consumption and CO2 emissions that take …

Low-Carbon City Policy Databook: 72 Policy Recommendations For Chinese Cities From The Benchmarking And Energy Savings Tool For Low Carbon Cities, L Price, N Zhou, D Fridley, Stephanie Ohshita, N Khanna, Hongyou Lu, L Hong, G He, J Romankiewicz, M Hu

Environmental Science

This report is designed to help city authorities evaluate and prioritize more than 70 different policy strategies that can reduce their city’s energy use and carbon-based greenhouse gas emissions of carbon dioxide (CO2) and methane (CH4). Local government officials, researchers, and planners can utilize the report to identify policies most relevant to local circumstances and to develop a low carbon city action plan that can be implemented in phases, over a multi-year timeframe.

The policies cover nine city sectors: industry, public and commercial buildings, residential buildings, transportation, power and heat, street lighting, water & wastewater, solid waste, and urban green …

Best Cities: Software User Guide, Stephanie Ohshita, C Fino-Chen, L Hong, N Khanna

Environmental Science

The Benchmarking and Energy-Saving Tool for Low Carbon Cities (BEST Cities) is a dynamic decision-making tool, designed to assist local policy makers and urban planners in prioritizing strategies for energy and carbon saving at the city level in China.

China’s 12^th Five-Year Plan (2011-2015) targets a reduction in carbon intensity of the economy (CO₂ emissions per unit of GDP) by 17%. In the "Low Carbon Development 2014-2015 energy saving action plan," the State Council calls for interim targets of more than 4% in 2014 and more than 3.5% in 2015. The …

Competitive Mothers: Comparing Competitiveness In Spheres That Matter, Alessandra Cassar, F Wordofa, Y J. Zhang

Economics Faculty Publications

Recent advances have highlighted the evolutionary significance of female competition, with the sexes pursuing different competitive strategies and females reserving their most intense competitive behaviors for the benefit of offspring (1-3). Influential economic experiments using cash incentives, however, have found evidence suggesting that women have a lower desire to compete than men (4-7). We hypothesize that the estimated gender differences critically depend on how we elicit them, especially on the incentives used. We test this hypothesis through an experiment with adults in China (n=358). Data show that, once the incentives are switched from monetary to childbenefitting, gender differences disappear. This …

The Effect Of Internally Versus Externally Focused Balance Training On Mindfulness, Kathleen J. Pantano, Jeremy E. C. Genovese

International Journal of Transpersonal Studies

The purpose of this study was to determine how alternative types of instruction provided during a 6-week balance exercise program affect mindfulness. A sample of 63 college students was recruited for the study. Group 1 (N = 33) received a 6-week balance exercise intervention instructed with an internal focus of attention (IFA). Group 2 (N = 30) received the same intervention, but exercises were instructed with an external focus of attention (EFA). Mindfulness was measured at baseline and at 6 weeks using the Freiburg Mindfulness Inventory (FMI). Baseline FMI scores between groups were similar (Group 1: 41.6; Group 2: 41.3), …

Deciphering The Mode Of Action Of The Processive Polysaccharide Modifying Enzyme Dermatan Sulfate Epimerase 1 By Hydrogen-Deuterium Exchange Mass Spectrometry, Emil Tykesson, Yang Mao, Marco Maccarana, Yi Pu, Jinshan Gao, Cheng Lin, Joseph Zaia, Gunilla Westergren-Thorsson, Ulf Ellervik, Lars Malmström, Anders Malmström

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Distinct from template-directed biosynthesis of nucleic acids and proteins, the enzymatic synthesis of heterogeneous polysaccharides is a complex process that is difficult to study using common analytical tools. Therefore, the mode of action and processivity of those enzymes are largely unknown. Dermatan sulfate epimerase 1 (DS-epi1) is the predominant enzyme during the formation of iduronic acid residues in the glycosaminoglycan dermatan sulfate. Using recombinant DS-epi1 as a model enzyme, we describe a tandem mass spectrometry-based method to study the mode of action of polysaccharide processing enzymes. The enzyme action on the substrate was monitored by hydrogen-deuterium exchange mass spectrometry and …

Hydrogen Production With A Simple And Scalable Membraneless Electrolyzer, Glen O'Neil, Corey D. Christian, David E. Brown, Daniel V. Esposito

Department of Chemistry and Biochemistry Faculty Scholarship and Creative Works

Ion-conducting membranes are essential components in many electrochemical devices, but they often add substantial cost, limit performance, and are susceptible to degradation. This work investigates membraneless electrochemical flow cells for hydrogen production from water electrolysis that are based on angled mesh flow-through electrodes. These devices can be fabricated with as few as three parts (anode, cathode, and cell body), reflecting their simplicity and potential for low-cost manufacture. 3D printing was used to fabricate prototype electrolyzers that were demonstrated to be electrolyte agnostic, modular, and capable of operating with minimal product crossover. Prototype electrolyzers operating in acidic and alkaline solutions achieved …

Empirical Study Redux On Choice Of Law And Forum In M&A: The Data And Its Limits, Kyle Chen, Harold S. Haller, Juliet P. Kostritsky, Wojbor A. Woyczynski

Faculty Publications

The legal community has long recognized that business corporations heavily favor Delaware as the state of incorporation. However, a recent study of merger agreements from 2002 by Eisenberg and Miller suggested that despite Delaware’s prominence as the place of incorporation, companies “flee” from Delaware with respect to both choice of law and forum, and instead prefer New York. We set out to study data from 343 merger and acquisitions contracted on between January 1, 2011 and June 30, 2011 in an attempt to verify this conjecture. Our study is important for two reasons. First, the 2011 data set show that …

Global Youth: 2016 The New York Times Writing Competition: "Word (World) Of Yours", New York Times

Student Publications

"Word (World) of Yours" is a yearly writing competition organised by International New York Times (INYT). This year's topic is "Global Youth" and SMU's law student Chow Zi En has won the runner up in the University category. Listed below are articles written by SMU students:

• What is the Global Youth? by Chow Zi En, pp. 16-17
• The Vitality of the Global Youth by Chim Sher Ting, p. 43
• Global Youth for Global Change by Nicole Jo-Anne Varella, p. 44
• Youth without Quality Education - a Great Waste; a Great Threat by Rex Lee Jia Hor, Averill Chow Mingni, p. …

Best Practices To Increase Efficacy Of Graduate School Admissions Communications At Clark University, Diana Curran, Nikki Feinberg, Mitchell Kelley, Ruiqi Li, Anning Zhou

School of Professional Studies

Within the period of time that a graduate student deposits and subsequently arrives at their academic institution, receiving timely information is important for their preparation. This process has been deemed by the Deans of the Enterprise Schools at Clark University as one that needs further investigation. As such, this Capstone looks at the array of communication that goes out to each graduate student during this four-month period. The purpose of examining this communication is to analyze its effectiveness in engaging students. To analyze the effectiveness of this communication, surveys were distributed to current students in these schools to gather data …

Ultra-Wideband Antennas, Max Ammann, Matthias John, Giuseppe Ruvio

Books/Book chapters

The focus of UWB antenna research activity has matured in recent years and currently mainly concentrates on applications such as biomedicine and security. Early UWB antenna designs were driven by the FCC allocation of spectrum in 2002 and focussed on obtaining wide impedance bandwidths with reasonable group delay characteristics. Many of these were simple planar monopoles antennas with canonical geometries. The emergence of new applications channelled the emphasis towards miniaturisation and integration into devices. This required optimisation of the antenna geometries to ensure that good system performance is achieved from the integrated antenna. Many optimisation techniques are available including the …

The University Of Texas Of The Permian Basin Graduate Studies Catalog 2016-2018, The University Of Texas Of The Permian Basin

Course Catalogs

No abstract provided.

Quantitative Modeling Of Scaling Of Patterns And Receptor Signaling In Morphogenesis, Md Shahriar Karim

Open Access Dissertations

Organs and tissue development often experience perturbations, but developmental processes seem to replicate a common body template to maintain appropriate proportions and positions. The key signaling factors that guide a number of those processes are known as morphogens. Developing cells sense their respective positional information from a graded morphogen profile, and differentiate into patterns. Remarkably, patterns are highly robust and reproducible among species, and the underlying mechanisms associated with such high degrees of precision are still enigmatic. In addition, details of the signal, such as the Bone Morphogenetic Protein (BMP) signal, that transmit patterning information to a group of homogenous …

Linfield Digest, Linfield Magazine Staff

Linfield Magazine

Brief articles and photos of events and news about Linfield College

Bridgewater College Catalog, Session 2016-17, Bridgewater College

Bridgewater College Catalogs

No abstract provided.

Environmental Controls On Pyrocumulus And Pyrocumulonimbus Initiation And Development, Neil Lareau, Craig Clements

Faculty Publications, Meteorology and Climate Science

In this paper we present the first direct observational evidence that the condensation level in pyrocumulus and pyrocumulonimbus clouds can be significantly higher than the ambient lifted condensation level. In addition, we show that the environmental thermodynamic profile, day-to-day variations in humidity, and ambient wind shear all exert significant influence over the onset and development of pyroconvective clouds. These findings are established using a scanning Doppler lidar and mobile radiosonde system during two large wildfires in northern California, the Bald Fire and the Rocky Fire. The lidar is used to distinguish liquid water from smoke backscatter during the plume rise, …

Temporal Logic For System Safety Properties And Hazard Monitoring, Francesca Favaro, J. Saleh

Faculty Publications

No abstract provided.

Development Of Cloud-Based Uav Monitoring And Management System, Mason Itkin, Mihui Kim, Younghee Park

Faculty Publications

Unmanned aerial vehicles (UAVs) are an emerging technology with the potential to revolutionize commercial industries and the public domain outside of the military. UAVs would be able to speed up rescue and recovery operations from natural disasters and can be used for autonomous delivery systems (e.g., Amazon Prime Air). An increase in the number of active UAV systems in dense urban areas is attributed to an influx of UAV hobbyists and commercial multi-UAV systems. As airspace for UAV flight becomes more limited, it is important to monitor and manage many UAV systems using modern collision avoidance techniques. In this paper, …