Digital Commons Network^™

Author Correction: Il-12 Reprograms Car-Expressing Natural Killer T Cells To Long-Lived Th1-Polarized Cells With Potent Antitumor Activity, Elisa Landoni, Mark G Woodcock, Gabriel Barragan, Gabriele Casirati, Vincenzo Cinella, Simone Stucchi, Leah M Flick, Tracy A Withers, Hanna Hudson, Giulia Casorati, Paolo Dellabona, Pietro Genovese, Barbara Savoldo, Leonid S Metelitsa, Gianpietro Dotti

Faculty, Staff and Students Publications

No abstract provided.

Evolution Of Global Anatomy Research Through Covid-19: A Post-Pandemic Evaluation, Harsh Chheda, Santanu De

FDLA Journal

The Coronavirus Infectious Disease 2019 (COVID-19) struck the world with a deep impact on many countries' healthcare systems. More specifically, anatomical research experienced a drastic setback due to the limitations and restrictions placed upon them by the medical community. This study aims to review how COVID-19 guidelines presented conflict regarding the retrieval and use of cadavers, as well as how anatomy research was modified on a global scale owing to the pandemic. The COVID-19 outbreak called for several changes upon each significant anatomical research technique, ranging from cadaver dissection to diagnostic imaging. Given the remarkable shift in medical research guidelines …

Global Implications Of Covid-19 On Education And Research In Healthcare And Stem: Analysis Of Case Studies, Yumna Indorewala, Santanu De

FDLA Journal

The zoonotic novel coronavirus, SARS-CoV-2 posed major threats to the world’s economy, social development, and public health. Education and research in STEM and healthcare were no exceptions to the global implications of the Coronavirus Infectious Disease 2019 (COVID-19) pandemic. Social distancing guidelines were initially recommended to refrain from in-person operations for preventing the transmission of the virus. As academic organizations implemented multifarious methods to effectively transition to remote/online or hybrid educational formats, COVID-19 necessitated designing, adopting, as well as evaluating the efficacy of new instructional approaches, especially for disciplines that require active, experiential learning such as healthcare and STEM. These …

The Relationship Between Magnet And Non-Magnet Designated Sites And Severe Maternal Morbidity For New Jersey Hospitals, Adrienne L. Elberfeld

Walden Dissertations and Doctoral Studies

For the past 25 years U.S. health care providers have reported higher than expected severe maternal morbidity (SMM). Magnet status is a designation through the American Nurses Credentialing Center (ANCC). Studies indicate that hospitals with Magnet recognition provide better patient care resulting in better quality outcomes. The recent COVID-19 pandemic (COVID-19) created a global-wide disruption, presenting new systemic challenges for U.S. health care providers in providing accessible, timely patient health services. The purpose of this study was to determine if there is a statistically significant difference between Magnet and non-Magnet hospitals in New Jersey (NJ) for SMM rates during COVID-19 …

Pharmacy Federal Grant To Propel Vaccine Technology Research, Natalie Ehrhardt

University of Mississippi News

OXFORD, Miss. – The U.S. Food and Drug Administration has awarded some $500,000 to University of Mississippi pharmacy professor Mo Maniruzzaman, with a recommendation for another $500,000 in 2025, to develop a technology that promises to streamline vaccine production.

The Relationship Between Magnet And Non-Magnet Designated Sites And Severe Maternal Morbidity For New Jersey Hospitals, Adrienne L. Elberfeld

Walden Dissertations and Doctoral Studies

For the past 25 years U.S. health care providers have reported higher than expected severe maternal morbidity (SMM). Magnet status is a designation through the American Nurses Credentialing Center (ANCC). Studies indicate that hospitals with Magnet recognition provide better patient care resulting in better quality outcomes. The recent COVID-19 pandemic (COVID-19) created a global-wide disruption, presenting new systemic challenges for U.S. health care providers in providing accessible, timely patient health services. The purpose of this study was to determine if there is a statistically significant difference between Magnet and non-Magnet hospitals in New Jersey (NJ) for SMM rates during COVID-19 …

Exploring The Experiences Of Hiv Positive Pregnant Women On Prevention Of Vertical Transmission Of Hiv/Aids In Rural Malawi, Gertrude Finyiza

Electronic Theses and Dissertations

Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) continues to be the primary conduct that HIV is transmitted to children worldwide. The problem of HIV/acquired immunodeficiency syndrome (AIDS) is having a great impact on the world's children. The prevalence of HIV/AIDS in Malawi continues to be a serious public health issue, especially for expectant mothers. The health outcomes of mothers and children remain significantly threatened by vertical HIV transmission, even with improvements in preventive and treatment efforts. The purpose of this thesis was to explore the experiences of HIV-positive pregnant women in Malawi. I conducted semi structured interviews with thirteen …

Establishment Of A Research Site At The Kennedy Mountain Campus For The Observation Of Airborne Particulate Matter, Alyssa Knaus

Undergraduate Theses, Capstones, and Recitals

This thesis explored particulate matter (PM) concentrations at two sites within the Colorado Front Range. The study utilized two models of PurpleAir PM sensors, Flex and SD-II, to provide real-time, accessible data on PM1, PM2.5, and PM10 mass concentrations with the goal of establishing the first research site at the Kennedy Mountain Campus (KMC). The first of the two sites used during this study was at a suburban location outside of Denver, CO. This period was used as an instrument intercomparison period in order to conduct instrument analysis. The initial findings from this period found significant correlations between PM concentration …

Anomalous Presentation And Endoscopic Findings Of Acute Esophageal Necrosis: A Case Report, Ahmed Shehadah, Abdullah A. Orakzai, Sheza Malik, Alshaima Yousef, Ali Jaan, Patrick Okolo

Advances in Clinical Medical Research and Healthcare Delivery

Introduction:

Acute esophageal necrosis (AEN), is a rare disorder with an estimated incidence of 0.01-0.28%. It typically affects the distal third of the esophagus. Approximately 90% of patients with acute esophageal necrosis present with upper gastrointestinal (GI) bleeding, primarily due to ischemic insult or severe hemodynamic compromise. In this report, we describe a case in which the patient presented with odynophagia and dysphagia, but without upper GI bleeding. The patient exhibited pan mucosal involvement of the esophagus, which extended to the gastric antrum.

Case: A 55-year-old man with a history of type 2 diabetes mellitus and substance abuse presented with …

Perspectives On Computational Modeling Of Biological Systems And The Significance Of The Sysmod Community, Bhanwar Lal Puniya, Meghna Verma, Chiara Damiani, Shaimaa Bakr, Andreas Dräger

Department of Biochemistry: Faculty Publications

Motivation: In recent years, applying computational modeling to systems biology has caused a substantial surge in both discovery and practical applications and a significant shift in our understanding of the complexity inherent in biological systems.

Results: In this perspective article, we briefly overview computational modeling in biology, highlighting recent advancements such as multiscale modeling due to the omics revolution, single-cell technology, and integration of artificial intelligence and machine learning approaches. We also discuss the primary challenges faced: integration, standardization, model complexity, scalability, and interdisciplinary collaboration. Lastly, we highlight the contribution made by the Computational Modeling of Biological Systems …

Persistent Gram-Negative Bloodstream Infection Increases The Risk Of Recurrent Bloodstream Infection With The Same Species, Paa Kwesi Ankrah, Andrew Bock, Felicia Ruffin, Blake M Hanson, Cesar A Arias, Stacey A Maskarinec, Joshua Parsons, Vance G Fowler, Joshua T Thaden

Faculty, Staff and Student Publications

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Evaluating The Influence Of Perfluorooctane Sulfonic Acid Exposure On Blood Glucose Levels: A Comprehensive Multiple Regression Analysis Considering Confounding Factors, Henry Mensah

Theses and Dissertations

Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% …

Elementary School Teachers’ Lived Experience Teaching Remotely During The Covid-19 Pandemic, Natasha Gorman

Walden Dissertations and Doctoral Studies

Teaching experiences changed during COVID-19 from face-to-face to online, and teachers encountered numerous challenges. Considerable research has been conducted on many of the issues that teachers at different grade levels faced in this transition. The experiences of elementary school teachers, however, have not received much attention. The purpose of this qualitative study was to explore the lived experiences of elementary school teachers who taught remotely during the COVID-19 pandemic. Understanding their challenges may lead to the development of appropriate resources and specific training for teachers in these early grades. The theoretical foundation that grounded this study was Bronfenbrenner’s ecological systems …

Elementary School Teachers’ Lived Experience Teaching Remotely During The Covid-19 Pandemic, Natasha Gorman

Walden Dissertations and Doctoral Studies

Teaching experiences changed during COVID-19 from face-to-face to online, and teachers encountered numerous challenges. Considerable research has been conducted on many of the issues that teachers at different grade levels faced in this transition. The experiences of elementary school teachers, however, have not received much attention. The purpose of this qualitative study was to explore the lived experiences of elementary school teachers who taught remotely during the COVID-19 pandemic. Understanding their challenges may lead to the development of appropriate resources and specific training for teachers in these early grades. The theoretical foundation that grounded this study was Bronfenbrenner’s ecological systems …

Persistent Gram-Negative Bloodstream Infection Increases The Risk Of Recurrent Bloodstream Infection With The Same Species, Paa Kwesi Ankrah, Andrew Bock, Felicia Ruffin, Blake M Hanson, Cesar A Arias, Stacey A Maskarinec, Joshua Parsons, Vance G Fowler, Joshua T Thaden

Faculty, Staff and Student Publications

The association between persistent gram-negative bloodstream infection (GN-BSI), or ongoing positive cultures, and recurrent GN-BSI has not been investigated. Among 992 adults, persistent GN-BSI was associated with increased recurrent GN-BSI with the same bacterial species and strain (6% vs 2%; P = .04). Persistent GN-BSI may be a marker of complicated infection.

Update On Outbreak Of Fungal Meningitis Among Us Residents Who Received Epidural Anesthesia At Two Clinics In Matamoros, Mexico, Dallas J Smith, Jeremy A W Gold, Tom Chiller, Nirma D Bustamante, Maria Julia Marinissen, Gabriel Garcia Rodriquez, Vladimir Brian Gonzalez Cortes, Celida Duque Molina, Samantha Williams, Axel A Vazquez Deida, Katrina Byrd, Peter G Pappas, Thomas F Patterson, Nathan P Wiederhold, George R Thompson, Luis Ostrosky-Zeichner

Faculty, Staff and Student Publications

Background: Public health officials are responding to an outbreak of fungal meningitis among patients who received procedures under epidural anesthesia at 2 clinics (River Side Surgical Center and Clinica K-3) in Matamoros, Mexico, during 1 January to 13 May 2023. This report describes outbreak epidemiology and outlines interim diagnostic and treatment recommendations.

Methods: Interim recommendations for diagnosis and management were developed by the Mycoses Study Group Research Education and Consortium (MSGERC) based on the clinical experience of clinicians caring for patients during the current outbreak or during previous outbreaks of healthcare-associated fungal meningitis in Durango, Mexico, and the United States. …

Current And Future Environmental Suitability For Bats Hosting Potential Zoonotic Pathogens In Rural Kenya, Ruut Uusitalo, Reilly T. Jackson, Tamika J. Lunn, Essi M. Kohonen, Joseph G. Ogala, Paul W. Wabala, Tarja A. Sironen, Kristian M. Forbes

Biological Sciences Faculty Publications and Presentations

Synanthropic bats live in close proximity to humans and domestic animals, creating opportunities for potential pathogen spillover. We explored environmental correlates of occurrence for a widely distributed synanthropic African bat, Mops pumilus—a species associated with potential zoonotic viruses—and estimated current and future environmental suitability in the Taita Hills region and surrounding plains in Taita–Taveta County in southeast Kenya. To project future environmental suitability, we used four Coupled Model Intercomparison Project Phase 6 general circulation models that capture temperature and precipitation changes for East Africa. The models were parameterized with empirical capture data of M. pumilus collected …

Viral And Host Factors Are Associated With Mortality In Hospitalized Patients With Covid-19, Neil R Aggarwal, Jacquie Nordwall, Dominique L Braun, Lucy Chung, Jordan Coslet, Tatyana Der, Nnakelu Eriobu, Adit A Ginde, Awori J Hayanga, Helene Highbarger, Mark Holodniy, Juan P Horcajada, Mamta K Jain, Kami Kim, Sylvain Laverdure, Jens Lundgren, Ven Natarajan, Hien H Nguyen, Sarah L Pett, Andrew Phillips, Garyphallia Poulakou, David A Price, Philip Robinson, Angela J Rogers, Uriel Sandkovsky, Katy Shaw-Saliba, Jeffrey M Sturek, Barbara W Trautner, Michael Waters, Cavan Reilly

Faculty, Staff and Students Publications

BACKGROUND: Persistent mortality in adults hospitalized due to acute COVID-19 justifies pursuit of disease mechanisms and potential therapies. The aim was to evaluate which virus and host response factors were associated with mortality risk among participants in Therapeutics for Inpatients with COVID-19 (TICO/ACTIV-3) trials.

METHODS: A secondary analysis of 2625 adults hospitalized for acute SARS-CoV-2 infection randomized to 1 of 5 antiviral products or matched placebo in 114 centers on 4 continents. Uniform, site-level collection of participant baseline clinical variables was performed. Research laboratories assayed baseline upper respiratory swabs for SARS-CoV-2 viral RNA and plasma for anti-SARS-CoV-2 antibodies, SARS-CoV-2 nucleocapsid …

A Phase 2 Clinical Trial To Evaluate The Safety, Reactogenicity, And Immunogenicity Of Different Prime-Boost Vaccination Schedules Of 2013 And 2017 A(H7n9) Inactivated Influenza Virus Vaccines Administered With And Without As03 Adjuvant In Healthy Us Adults, Christina A Rostad, Robert L Atmar, Emmanuel B Walter, Sharon Frey, Jeffery L Meier, Amy C Sherman, Lilin Lai, Rachel Tsong, Carol M Kao, Vanessa Raabe, Hana M El Sahly, Wendy A Keitel, Jennifer A Whitaker, Michael J Smith, Kenneth E Schmader, Geeta K Swamy, Getahun Abate, Patricia Winokur, Wendy Buchanan, Kaitlyn Cross, Ashley Wegel, Yongxian Xu, Inci Yildirim, Satoshi Kamidani, Nadine Rouphael, Paul C Roberts, Mark J Mulligan, Evan J Anderson

Center for Medical Ethics and Health Policy Staff Publications

Introduction: A surge of human influenza A(H7N9) cases began in 2016 in China from an antigenically distinct lineage. Data are needed about the safety and immunogenicity of 2013 and 2017 A(H7N9) inactivated influenza vaccines (IIVs) and the effects of AS03 adjuvant, prime-boost interval, and priming effects of 2013 and 2017 A(H7N9) IIVs.

Methods: Healthy adults (n = 180), ages 19-50 years, were enrolled into this partially blinded, randomized, multicenter phase 2 clinical trial. Participants were randomly assigned to 1 of 6 vaccination groups evaluating homologous versus heterologous prime-boost strategies with 2 different boost intervals (21 vs 120 days) and 2 …

A Randomized, Double-Blind, Phase 3 Safety And Efficacy Study Of Ridinilazole Versus Vancomycin For Treatment Of Clostridioides Difficile Infection: Clinical Outcomes With Microbiome And Metabolome Correlates Of Response, Pablo C Okhuysen, Erik R Dubberke, Et Al.

2020-Current year OA Pubs

BACKGROUND: Exposure to antibiotics predisposes to dysbiosis and Clostridioides difficile infection (CDI) that can be severe, recurrent (rCDI), and life-threatening. Nonselective drugs that treat CDI and perpetuate dysbiosis are associated with rCDI, in part due to loss of microbiome-derived secondary bile acid (SBA) production. Ridinilazole is a highly selective drug designed to treat CDI and prevent rCDI.

METHODS: In this phase 3 superiority trial, adults with CDI, confirmed with a stool toxin test, were randomized to receive 10 days of ridinilazole (200 mg twice daily) or vancomycin (125 mg 4 times daily). The primary endpoint was sustained clinical response (SCR), …

Mathematical Modeling Of An Epidemic In Scale-Free Network With Imperfect Vaccination, Heba Hameed

Thesis/ Dissertation Defenses

In light of the recent COVID-19 pandemic, the mathematical epidemiological model has proven to be essential for understanding the disease dynamic and finding the best control tool to help contain the disease and minimize its impact. This thesis investigates the dynamics of an infectious disease spread with latent infection and vaccination. The aim is to study this model's dynamic in a network that reflects the heterogeneity of the environment where the disease spreads. The vaccination is assumed to be not perfect, which means that vaccinated persons are likely to be infected and that the vaccinated person could lose their immunity, …

Mash: Advances In Treatment And Triage During The Korean War, Ryan Planer

Chronos

No abstract provided.

Housing Affordability: Determining The Percentage Of Working-Class Millennials To Afford Renting A Studio-Type Condominium In Bonifacio Global City, Johara B. Piega, Ricardo Cholo L. Santos

DLSU Senior High School Research Congress

Proper housing is vital for sustainable environments and for an individual’s well-being — providing security, emotional stability, and a sense of belonging. However, the Philippines faces challenges in providing affordable shelter, especially as it has remained in the lower-middle income bracket alongside other Southeast Asian countries for over three decades. Bonifacio Global City (BGC) stands as Metro Manila’s premier business district and contributes to the affordability for housing in the country. This study focuses on the affordability of studio-type condominiums in BGC for working-class Millennials aged 28-43. Conducted through quantitative research methods and a descriptive design, it employed snowball and …

Antimycotic Potential Of Eleusine Indica (Paragis) Leaf Extract Against Candida Albicans And Trichosporon Spp., Allijah Isabel D. Reyes, Lei Eirah M. Reforzado, Matthew Lewis B. Mariano, Lheichelle Anne F. Balagot

DLSU Senior High School Research Congress

Candida albicans and Trichosporon are fungal species that cause candidiasis and trichosporonosis, which are common fungal infections in the Philippines. Due to its growing resistance to antifungal drugs, studies that explore herbal plant alternatives have arisen. The present study was conducted to evaluate the antimycotic activity of Eleusine indica (Paragis) plant crude extract against C. albicans and Trichosporon spp.. E. indica is an invasive plant native to the Philippines that has been proven to possess bioactive compounds such as flavonoids, alkaloids, steroids, essential oils, coumarins, fatty acids, anthraquinone, yield from the inhibitory extraction method, along with factors such as the …

Medical School Watercooler Newsletter - June 13, 2024, Lindsey Lyle

Watercooler Newsletter

This is the June 13, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Dolma shares research on premature infants at two conferences
• Medical student presents research at international MS conference
• USA awarded $1.43 million, selected as clinical site for dementia study
• Medical students present interesting case reports at annual symposium

Mechanistic Study Of Antimicrobial Effectiveness Of Cyclic Amphipathic Peptide [R4W4] Against Methicillin-Resistant Staphylococcus Aureus Clinical Isolates, Ajayi David Akinwale, Keykavous Parang, Rakesh Kumar Tiwari, Jason Yamaki

Pharmacy Faculty Articles and Research

Antimicrobial peptides (AMPs) are being explored as a potential strategy to combat antibiotic resistance due to their ability to reduce susceptibility to antibiotics. This study explored whether the [R₄W₄] peptide mode of action is bacteriostatic or bactericidal using modified two-fold serial dilution and evaluating the synergism between gentamicin and [R₄W₄] against Escherichia coli (E. coli) and methicillin-resistant Staphylococcus aureus (MRSA) by a checkered board assay. [R₄W₄] exhibited bactericidal activity against bacterial isolates (MBC/MIC ≤ 4), with a synergistic effect with gentamicin against E. coli (FICI = 0.3) but …

Development And Validation Of Autotronic Training Module For Automobile Technology Students In Polytechnics In Southern Nigeria, Saue, Baritule Prince, Chukuigwe, Ogbondah Nndameka, Bassey, Imaobong Sunday

Journal of Informatics and Web Engineering

A research was carried out to create and verify an autotronic training module for students studying vehicle technology at polytechnics located in Southern Nigeria. The design used for the project was Research and Development (R&D). An observation has been made that the curriculum of polytechnics in Nigeria lacks sufficient substance on autotronics technology. As a result, lecturers have challenges in fully imparting the abilities that are essential for the professional world. Undoubtedly, there is now a disparity between the training that craftsmen receive and the skills that are demanded by industries. The research was carried out in the southern region …

Implementing An Antibiotic Stewardship Program Using The Mitigate Toolkit In An Urgent Care Setting, Christina Ross

DNP and Student Works

Antibiotic resistance is one of the utmost hazards to public and global health. On average, 2.8 million annual antibiotic-resistant infections in the U.S. and more than 35,000 deaths resulted in 2019. Increased resistance rates are related to worse clinical outcomes and healthcare costs - an increase in adverse reactions such as allergic reactions and Clostridium difficile infections results. The creation of Urgent Care (UC) clinics across the U. S. has increased access to healthcare but exceeded the national average of antibiotic prescriptions to maintain patient satisfaction. Developing an Antibiotic Stewardship Program (ASP) in a UC setting will reduce inappropriate antibiotic …

Neuroinflammation And Gut Barrier Function Post Traumatic Brain Injury, Anne Sullivan

Master's Theses

Traumatic Brain Injury (TBI) is a major cause of morbidity and mortality that afflicts millions of people in the United States annually. TBI mice had significantly increased expression of the pro-inflammatory cytokines and decreased expression of tight junction proteins CLDN5, CLDN12, and OCLD in brain lesion tissue. TBI mice exhibited a significant accumulation of FITC in the middle and distal part of the small intestine compared to sham mice. TBI mice exhibited an increase in pathogenic bacteria Enterobacteriaceae and a decrease in beneficial bacteria lactobacillus. TBI mice exhibited a trend toward an increase in permeability compared to no treatment. These …

Biological Lags And Market Dynamics In Vertically Coordinated Food Supply Chains: Hpai Impacts On U.S. Egg Prices, James L. Mitchell, Jada M. Thompson, Trey Malone

Department of Agricultural Economics Faculty Publications

It is well known that livestock production involves long biological lags. Failure to account for these biological lags can result in the misspecification of supply chain relationships and adjustments to market shocks, which can have significant implications for policy decisions. An example is the 2022 Highly Pathogenic Avian Influenza (HPAI) event that caused high mortality rates in domestic poultry supply chains and reduced egg production. We use the 2022–2023 HPAI event to highlight the implications of misspecification of disease dynamics in agri-food systems. Specifically, we examine the impact of HPAI on U.S. egg prices in 2022–2023. To do this, we …