Digital Commons Network^™

Fostering A Patient-Led Culture Of Care Through Data Physicalization: A Design Approach To Create Awareness And Promote Data Collection On Antimicrobial Resistance, Ginevra Terenghi, Serena Cangiano, Antonella Autuori, Cristina Margarida Corti

DRS Biennial Conference Series

The paradigm shift in healthcare delivery models is leading to individuals assuming greater responsibilities and control, as the agency is moving from doctor-centric to patient-centric. To foster a patient-led culture of care, health and data literacy are essential, especially in the context of global challenges, where citizen awareness is fundamental to play actively in co-creating knowledge. This paper outlines a methodological approach and the outcomes of a design research project focused on promoting engagement and literacy to facilitate citizen and patient participation in addressing the antimicrobial resistance threat. The approach is tested in the format of an experimental workshop, inspired …

Reimagining Antibiotic Delivery At Home: Designing A Wearable Cool-Infuser, Geoffrey Thompson, Rowan Page, Benjamin Rogers

DRS Biennial Conference Series

As antimicrobial resistance (AMR) intensifies, hospitals face increased pressure due to the high demand for bed spaces and the associated risks of hospital-acquired infections. Outpatient Antimicrobial Therapy (OPAT) offers a solution by enabling patients to receive life-saving intravenous antibiotic treatments in the community rather than in hospitals. However, temperature-sensitive antibiotics can degrade when exposed to heat, creating design challenges in OPAT settings. Current antibiotic infusion devices focus on the clinical need and outcomes of treatment, leaving room to improve the holistic patient experience of living with the device. Through a human-centred design approach, this project develops a Wearable cool-infuser that …

Event Booklet (Pdf), Department Of Orthopaedic Surgery

Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day

No abstract provided.

Novel Adaptations In Iron Regulation Acquired During Chronic Fungal Cf Infections, Daniel R. Murante

Dartmouth College Ph.D Dissertations

Chronic fungal infections are highly recalcitrant to treatment; we postulated that as populations persist, increasing genetic diversity is reflected in phenotypic heterogeneity, contributing to treatment inefficacies. The study of evolutionary patterns is underrepresented in chronic fungal infections, and to supplement this body of knowledge, we leveraged isolates acquired from four individuals with chronic fungal-dominated cystic fibrosis infections. We evaluated in-host evolution through a whole-genome sequencing approach, comparing multiple isolates obtained from each subject's sputum and bronchoalveolar lavage fluid. Our analysis found non-synonymous mutations that arose in parallel across the independent infections in the gene MRS4, which encodes a mitochondrial …

Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren

Theses and Dissertations

Hospital-acquired infections (HAIs) pose a significant and increasing threat to global health. One primary cause of this threat is increasing antibiotic resistance. As traditional antibiotics continue to grow less effective, there is an urgent need for novel antimicrobial strategies. This work explores the potential of ceragenins, also known as cationic steroid antimicrobials (CSAs), as a promising alternative to combat HAIs. Specifically, we investigated potential roles that CSAs can play in the context of multiple medical device coatings in healthcare settings. Ceragenins are synthetic mimic of antimicrobial peptides (AMPs) which exhibit broad-spectrum antimicrobial activity against many common pathogens that have been …

Pilgrimage In The Covid-19 Era: Uncovering Supply Side Challenges And Opportunities In Media Representations, Reni Polus, Ismail Shaheer, Naresh P. Nayak

International Journal of Religious Tourism and Pilgrimage

Pilgrimage travel, a common practice across major religions, has historically exhibited remarkable resilience to global crises, owing to the unwavering conviction of its followers. However, the COVID-19 pandemic marked a significant departure from this trend, disrupting pilgrimage tourism, unlike any event since World War II. Despite extensive research on the pandemic’s impact on tourism, limited attention has been directed towards understanding its specific effects on pilgrimage travel. This study seeks to address this gap by examining the challenges and opportunities faced by pilgrimage tourism suppliers in the aftermath of COVID-19. To obtain a comprehensive global perspective, we collected and analysed …

The Academic Influence Of The Camino De Santiago: A Bibliometric Analysis Of Doctoral Research And Indexed Manuscripts, Silvia Díaz-De La Fuente, Virginia Ahedo, María Pilar Alonso Abad, José Manuel Galán

International Journal of Religious Tourism and Pilgrimage

The Camino de Santiago is one of the most recognised cultural pilgrimage routes in the world. Notably, its current influence transcends the strictly inspirational and religious aspects, constituting also a socio-economic, cultural, historical, heritage and tourism cornerstone. This paper analyses, from an innovative bibliometric perspective, the influence of the Camino de Santiago on the academic literature in the period from 1980 to the present. For this purpose, two data sources have been used comparatively: manuscripts indexed in Scopus and doctoral theses. The results reveal a growth of its academic relevance in the last decade, especially in indexed publications. The analysis …

The Association Between Mental Health And Fibromyalgia In African Americans, Shalika J. Tisinger

Walden Dissertations and Doctoral Studies

Depression and fibromyalgia can often exacerbate each other and are known to be bidirectional disorders. Chronic pain from fibromyalgia often leads to depression, and depression can cause pain to become worse and affect the nervous system, causing pain. The purpose of this quantitative, binary logistic regression study is to determine if there is an association between mental health and fibromyalgia in African Americans while controlling for cardiovascular disease, chronic kidney disease, arthritis, education level (ie. Some high school, high school graduate, some college or higher), diet, poverty-income-ratio, PIR, diabetes, gender, and age. The socio-ecological model included in this cross-sectional study …

The Association Between Mental Health And Fibromyalgia In African Americans, Shalika J. Tisinger

Walden Dissertations and Doctoral Studies

Depression and fibromyalgia can often exacerbate each other and are known to be bidirectional disorders. Chronic pain from fibromyalgia often leads to depression, and depression can cause pain to become worse and affect the nervous system, causing pain. The purpose of this quantitative, binary logistic regression study is to determine if there is an association between mental health and fibromyalgia in African Americans while controlling for cardiovascular disease, chronic kidney disease, arthritis, education level (ie. Some high school, high school graduate, some college or higher), diet, poverty-income-ratio, PIR, diabetes, gender, and age. The socio-ecological model included in this cross-sectional study …

Elucidating Immune-Related Gene Transcriptional Programs Via Factorization Of Large-Scale Rna-Profiles, Shan He, Matthew M Gubin, Hind Rafei, Rafet Basar, Merve Dede, Xianli Jiang, Qingnan Liang, Yukun Tan, Kunhee Kim, Maura L Gillison, Katayoun Rezvani, Weiyi Peng, Cara Haymaker, Sharia Hernandez, Luisa M Solis, Vakul Mohanty, Ken Chen

Faculty, Staff and Student Publications

Recent developments in immunotherapy, including immune checkpoint blockade (ICB) and adoptive cell therapy (ACT), have encountered challenges such as immune-related adverse events and resistance, especially in solid tumors. To advance the field, a deeper understanding of the molecular mechanisms behind treatment responses and resistance is essential. However, the lack of functionally characterized immune-related gene sets has limited data-driven immunological research. To address this gap, we adopted non-negative matrix factorization on 83 human bulk RNA sequencing (RNA-seq) datasets and constructed 28 immune-specific gene sets. After rigorous immunologist-led manual annotations and orthogonal validations across immunological contexts and functional omics data, we demonstrated …

Clinical Prediction For Surgical Versus Nonsurgical Interventions In Patients With Vertebral Osteomyelitis And Discitis, Jennifer Lee, Miguel A. Ruiz-Cardozo, Rujvee P. Patel, Saad Javeed, Raj Swaroop Lavadi, Catherine Newsom-Stewart, Anton Alyakin, Camilo A. Molina, Nitin Agarwal, Wilson Z. Ray, Michele Santacatterina, Brenton H. Pennicooke

2020-Current year OA Pubs

BACKGROUND: Vertebral osteomyelitis and discitis (VOD), an infection of intervertebral discs, often requires spine surgical intervention and timely management to prevent adverse outcomes. Our study aims to develop a machine learning (ML) model to predict the indication for surgical intervention (during the same hospital stay) versus nonsurgical management in patients with VOD.

METHODS: This retrospective study included adult patients (≥18 years) with VOD (ICD-10 diagnosis codes M46.2,3,4,5) treated at a single institution between 01/01/2015 and 12/31/2019. The primary outcome studied was surgery. Candidate predictors were age, sex, race, Elixhauser comorbidity index, first-recorded lab values, first-recorded vital signs, and admit diagnosis. …

Advancing Clinical Microbiology: Applications And Future Of Next-Generation Sequencing, Rob E. Carpenter

Human Resource Development Faculty Publications and Presentations

Next-generation sequencing (NGS) has reformed infectious disease management, including COVID-19. While real-time polymerase chain reaction (PCR) is widely used for rapid pathogen detection, it requires predefined targets. NGS offers an unbiased approach, detecting multiple pathogens simultaneously without prior knowledge. Despite its potential, NGS implementation in clinical settings faces challenges like high costs and technical complexity. NGS platforms like Illumina, Ion Torrent, and Nanopore provide high-throughput sequencing, identifying pathogens and resistance markers. Applications include whole genome sequencing (WGS), metagenomic NGS (mNGS), and targeted NGS (tNGS). Integrating NGS with conventional methods could improve diagnostics, but current evidence is mixed for supporting its …

Immune Responses To Mycobacterium Tuberculosis Infection In The Liver Of Diabetic Mice, Ali Badaoui, Kayvan Sasaninia, Aishvaryaa Shree Mohan, Abrianna Beever, Nala Kachour, Anmol Raien, Afsal Kolloli, Ranjeet Kumar, Santhamani Ramasamy, Selvakumar Subbian, Vishwanath Venketaraman

Student Publications

Individuals with uncontrolled diabetes are highly susceptible to tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) infection. Novel treatments for TB are needed to address the increased antibiotic resistance and hepatoxicity. Previous studies showed that the administration of liposomal glutathione (L-GSH) can mitigate oxidative stress, bolster a granulomatous response, and diminish the M. tb burden in the lungs of M. tb-infected mice. Nonetheless, the impact of combining L-GSH with conventional TB treatment (RIF) on the cytokine levels and granuloma formation in the livers of diabetic mice remains unexplored. In this study, we evaluated hepatic cytokine profiles, GSH, and tissue pathologies …

Changes In Plasma Concentrations Of Per- And Polyfluoroalkyl Substances After Bariatric Surgery In Adolescents From The Teen-Longitudinal Assessment Of Bariatric Surgery (Teen-Labs) Study, Brittney O Baumert, Sandrah P Eckel, Jesse A Goodrich, Zhenjiang Li, Nikos Stratakis, Douglas I Walker, Yinqi Zhao, Fabian Christoph Fischer, Scott Bartell, Damaskini Valvi, Xiangping Lin, Zoe Coates Fuentes, Thomas Inge, Justin Ryder, Todd Jenkins, Rohit Kohli, Stephanie Sisley, Stavra Xanthakos, Sarah Rock, Michele A La Merrill, Rob Mcconnell, David V Conti, Lida Chatzi

Faculty, Staff and Students Publications

Exposure to per- and poly-fluoroalkyl substances (PFAS) is ubiquitous due to their persistence in the environment and in humans. Extreme weight loss has been shown to influence concentrations of circulating persistent organic pollutants (POPs). Using data from the multi-center perspective Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort, we investigated changes in plasma-PFAS in adolescents after bariatric surgery. Adolescents (Mean age = 17.1 years, SD = 1.5 years) undergoing bariatric surgery were enrolled in the Teen-LABS study. Plasma-PFAS were measured at the time of surgery and then 6-, 12-, and 36 months post-surgery. Linear mixed effect models were used to evaluate …

Advanced Hiv Disease And Associated Factors Among Young People Aged 15-24 Years At A Tertiary Hospital In Sierra Leone: A Cross-Sectional Study, Mamadu Baldeh, Samuel Kizito, Sulaiman Lakoh, Daniel Sesay, Samuel Adeyemi Williams, Umu Barrie, Frida Dennis, Dimbintsoa Rakotomalala Robinson, Franck Lamontagne, Franck Amahowe, Patrick Turay, Ozge Sensoy Bahar, Elvin Geng, Fred M Ssewamala

2020-Current year OA Pubs

BACKGROUND: Advanced HIV disease (AHD) in young people living with HIV (PLHIV) is an increasingly pressing public health issue in sub-Saharan Africa. Despite global progress in early HIV testing and reducing HIV-related deaths, many youths experience increased rates of HIV disease progression in sub-Saharan Africa. This study describes the burden, clinical manifestations, and factors for disease progression among young PLHIV aged 15 - 24 years seeking medical services at a major public hospital in Sierra Leone.

METHODS: We performed a cross-sectional analysis of routinely collected data for PLHIV patients aged 15 to 24 seen at Connaught Hospital in Sierra Leone …

Around The Center, 1998 August/September, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on art therapy.

Around The Center, 1997 June, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the Creticos Cancer Center.

Around The Center, 1997 November/December, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on the affiliation with Norwegian-American Hospital.

Around The Center, 1996 March, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and a feature on patient satisfaction surveys.

Residential Older Adults’ Experiences Related To Mental Health From Covid-19 Isolation, Heidi Beth Lubetkin

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic exacerbated many illnesses afflicting older adults in U.S. communities, including mental health wellness. Since 2020, at the inception of the pandemic, older adults living in residential settings, including assisted living and skilled nursing homes, experienced harsh limitations in their everyday lives. The conditions included prolonged periods of isolation and reduced interactions between caregivers and loved ones. Therefore, it is important to understand the experiences of older adults living in facilities and their ability to adapt to the environment. The research question addressed in this study gained insight into the effects of mandated isolation on older adults. Using …

Challenges And Opportunities In Cancer Immunotherapy: A Society For Immunotherapy Of Cancer (Sitc) Strategic Vision, Leisha A Emens, Pedro J Romero, Ana Carrizosa Anderson, Tullia C Bruno, Christian M Capitini, Deborah Collyar, James L Gulley, Patrick Hwu, Avery D Posey, Ann W Silk, Jennifer A Wargo

Faculty, Staff and Student Publications

Cancer immunotherapy has flourished over the last 10-15 years, transforming the practice of oncology and providing long-term clinical benefit to some patients. During this time, three distinct classes of immune checkpoint inhibitors, chimeric antigen receptor-T cell therapies specific for two targets, and two distinct classes of bispecific T cell engagers, a vaccine, and an oncolytic virus have joined cytokines as a standard of cancer care. At the same time, scientific progress has delivered vast amounts of new knowledge. For example, advances in technologies such as single-cell sequencing and spatial transcriptomics have provided deep insights into the immunobiology of the tumor …

Residential Older Adults’ Experiences Related To Mental Health From Covid-19 Isolation, Heidi Beth Lubetkin

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic exacerbated many illnesses afflicting older adults in U.S. communities, including mental health wellness. Since 2020, at the inception of the pandemic, older adults living in residential settings, including assisted living and skilled nursing homes, experienced harsh limitations in their everyday lives. The conditions included prolonged periods of isolation and reduced interactions between caregivers and loved ones. Therefore, it is important to understand the experiences of older adults living in facilities and their ability to adapt to the environment. The research question addressed in this study gained insight into the effects of mandated isolation on older adults. Using …

Lived Experiences, Perceptions, And Caregiving Trajectories Of Family Caregivers Of Youth With Substance Use Disorders (Suds) In Zambia, Ireen Manase Kabembo

Lingnan Theses (MPhil & PhD)

There is unequivocal evidence that family caregivers contribute to healthcare systems worldwide by providing care for persons with chronic illnesses in the home setting. his study explores the lived experiences, perceptions, and caregiving trajectories of 30 family caregivers of youth aged 16-24 diagnosed with Substance Use Disorders (SUDs) in Zambia. Data was collected through in-depth semi-structured interviews, a caregiving timeline, and participant observation and analysed using interpretative phenomenological analysis. Guided by the integrated theoretical framework of positioning theory and the theory of caregiving dynamics, this study offers a new lens for understanding caregiver’s experiences regarding caregiver identity, self-perceptions, interpersonal relationships, …

Synthetic Assembly Of Antibacterial Agents And Metal Chelating Ligands, Zachary Joseph Liveris

Dissertations

The exploitation of chemical synthesis exemplifies the notion of bridging both innovation and curiosity for the strategic assembly of sophisticated molecular infrastructures. By exerting this continuously evolving and versatile tool, synthesis has been applied in the development and influence of a myriad of ligands, biological probes, and persists to direct pharmaceutical innovation and modern medicine alike. Since pathogenic multidrug-resistant (MDR) microbial strains remain to be a persistent threat to both clinical healthcare and society, the need to develop selective and efficacious antibacterial agents that can impede microbe pathogenicity and regulate cellular mortality is paramount. In contrast to pharmaceutical development, organic …

A Qualitative Descriptive Study Of Therapists And Their Work With Socially Isolated Female Victims Of Sexual Violence Amid The Covid-19 Pandemic, Iris Lazette Saldivar

Doctoral Dissertations and Projects

The purpose of this qualitative descriptive study was to assess the experiences of therapists and the descriptions of their navigation processes while working with female victims of sexual violence who were socially isolated during the COVID-19 pandemic in the state of Texas. The theory that guided this study was the theoretical framework of loneliness, social isolation, and associated health outcomes. The research study focuses on two research questions that sought to examine the experiences and navigation of virtual treatment of therapists who provided counseling during the COVID-19 pandemic from March 2020 to March 2022. This study sought to find a …

Effect Of Incarceration On Prisoners Diagnosed With Mental Health Conditions: Trauma, Treatment, And Transitioning, Ingria S. Haywood

Doctoral Dissertations and Projects

A mental illness is a medical disorder that affects a person’s behavior, thoughts, and emotions. It also has an impact on social and cognitive functions. Misuse of substances, biological factors, or abuse, whether as a victim or a bystander to repeated abuse, are all variables that contribute to mental illness. The prevalence of mental illness among incarcerated prisoners is alarming, and it is nondiscriminatory in that it affects both men and women. Several variables contribute to inmates’ susceptibility to mental health problems. Anxiety disorders, depression as a mood disorder, dementia, and schizophrenia are examples of these. A diagnosis of mental …

Examining The Cues To Action Of Christian Parents And/Or Guardians Who Are Hesitant To Vaccinate Pediatric Populations, Marcia S. Jackson

Doctoral Dissertations and Projects

As a result of skepticism related to vaccine administration, many newborns and children are without their standardized and recommended vaccinations due to parent and/or guardian beliefs. It is the parent and/or guardian who holds the power to vaccinate their children. Vaccine administration is one of the most successful achievements of public health intervention in the 20th century. The purpose of this study is to use a descriptive case study analysis approach to assess parents' and/or guardians' concerns, attitudes, beliefs, and intentions towards immunizations for their children (from birth to 18 years of age). Understanding the "why" and "how" concerns raised …

Around The Center, 1994 April/May, Advocate Health - Midwest

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Around the Center", an employee newsletter. This issue has staffing and departmental updates, patient letters, and features on the annual meeting and the sleep disorder clinic.

Identifying Overdose Risk Factors For People Hospitalized With Injection Drug Use-Associated Infections In Maine, Melanie Mait, Kim Murray, Tania D. Strout, Kinna Thakarar

Journal of Maine Medical Center

Introduction: The overdose crisis continues to be a significant problem, particularly in rural states such as Maine. The objectives of this study were to: 1) describe demographic and health characteristics and 2) identify overdose risk factors among people in Maine hospitalized with injection drug use (IDU)-associated infections.

Methods: We performed descriptive analysis of demographics, health characteristics, and injection practices, stratified by lifetime history of overdose. We conducted an exploratory logistic regression analysis, controlling for gender, homelessness, having experienced an emergency department (ED) visit in the past 3-months, and endorsement of injecting alone in the past 30 days to examine …

Repeat Controlled Human Plasmodium Falciparum Infections Delay Bloodstream Patency And Reduce Symptoms, Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Faculty, Staff and Student Publications

Resistance to clinical malaria takes years to develop even in hyperendemic regions and sterilizing immunity has rarely been observed. To evaluate the maturation of the host response against controlled repeat exposures to P. falciparum (Pf) NF54 strain-infected mosquitoes, we systematically monitored malaria-naïve participants through an initial exposure to uninfected mosquitoes and 4 subsequent homologous exposures to Pf-infected mosquitoes over 21 months (n = 8 males) (ClinicalTrials.gov# NCT03014258). The primary outcome was to determine whether protective immunity against parasite infection develops following repeat CHMI and the secondary outcomes were to track the clinical signs and symptoms of malaria and anti-Pf antibody …