Digital Commons Network^™

Factory Farms And Labor Law: Can Unionization Get The Job Done?, Miranda Herreid

Animal Law Review

At different moments in U.S. history, workers have joined together to fight for a better future. Now more than ever, as industries become increas-ingly consolidated and powerful, workers’ ability to band together and ad-vocate for their rights is integral. Recent victories in labor rights have not yet made their way to the industrial animal agricultural sphere. This is unfortunate, as the conditions at slaughterhouses and concentrated animal feeding operations are extractive and abusive towards workers and animals alike. In the past, strong union presence in slaughterhouses aided workers in achieving wage increases and job stability. However, this resulted in extreme …

Developmental Regulation Of Corazonin, Eclosion Hormone, And Bursicon Messages And Rnai Suppression Of Corazonin In Adult Female American Dog Ticks, Dermacentor Variabilis, Anirudh Dhammi, Brooke Bissinger, Loganathan Ponnusamy, Daniel E. Sonenshine, R. Michael Roe

Biological Sciences Faculty Publications

The insect molting process is critical to growth and development and is regulated in part by the neuropeptides corazonin, eclosion hormone, and α and β bursicon. We found messages in a synganglion transcriptome from adult, female American dog ticks, Dermacentor variabilis (that do not molt), with a high similarity to the larval insect neuropeptides that control molting. The phylogenetic analysis of the tick putative neuropeptides compared to other arthropods is discussed in detail. The relative gene expression of these peptides was determined by quantitative PCR during the following adult developmental stages: (i) virgin, unfed 0–24 h after entering the adult …

Investigating The Metabolic Impact Of Metformin And Berberine In Combination With Venetoclax For Acute Myeloid Leukaemia Treatment, Samantha Robins

School of Biomedical Sciences Theses

Acute myeloid leukaemia (AML) stands as a significant challenge in haematological malignancies, particularly due to poor outcomes in older patients and resistance to therapy. BCL-2, an anti-apoptotic protein, is overexpressed in AML. The BCL-2 antagonist Venetoclax inhibits OXPHOS and induces apoptosis in AML cells, which is potentiated when combined with Metformin an anti-hyperglycaemic agent used to treat type 2 diabetes, which also has anti-cancer properties. This study explored the effects of Venetoclax combined with Metformin or Berberine, an herbal supplement with a similar mechanism of action to metformin, on AML cell death and metabolic changes. The combination of Metformin and …

Implementation Of A Code Sepsis Response Protocol In A Large Emergency Department Increases Rate Of Timely Antibiotic Administration In Patients With Suspected Sepsis, Leah Shults, Kailey Cox, Destiny Kramer, Grace Mariano, Amy Pinkos, Jordan Sanders, Kimberly Patterson

Articles, Abstracts, and Reports

No abstract provided.

Increasing Special Pathogen Preparedness At A Frontline Hospital: A Quality Improvement Project, Mckenna Freed, Christa Arguinchona, Barbara Bennett-Wolcott

Articles, Abstracts, and Reports

No abstract provided.

Resilience And Reality: Exploring The Lived Experiences Of People Living With Hiv In Texas During The Covid-19 Pandemic – A Qualitative Study., Ahmed F. Alanazi

Social Work Dissertations - Archive

This study investigated the lived experiences of individuals living with HIV (PLWH) in the Dallas-Fort Worth (DFW) area of Texas during the COVID-19 pandemic, using an Interpretative Phenomenological Analysis (IPA) framework. The research examined the intersection of health, social dynamics, and psychological resilience among PLWH, who faced compounded vulnerabilities due to systemic inequities and the dual public health crises of HIV and COVID-19. Through semi-structured interviews with ten participants from diverse backgrounds, the study captured the profound impacts of disrupted healthcare systems, heightened stigma, and social isolation on this marginalized population. The findings reveal that the pandemic exacerbated existing inequities …

Genetic Analysis Of Methionine Restriction-Associated Mitochondrial Unfolded Protein Response Signaling., Josh D. Dodge

Biology Dissertations - Archive

The lifespan of an organism is dictated by various genetic and environmental factors. One such determinant is the health of mitochondria which are organelles that mediate various critical cell functions including a significant role in generating the vast supply of cellular energy. Indeed, the gradual decline of mitochondrial function is believed to be a hallmark and possible cause of aging. Paradoxically, mild mitochondrial dysfunction early in life extends lifespan in various model organisms. Cells use diverse approaches to promote mitochondrial homeostasis, including the transcriptional reprogramming of cells by mitochondrial unfolded protein response (UPRmt) to mitigate mitochondrial stress. Consistently, UPRmt activation …

A Bioluminescent Approach To Coxiella Burnetii Pathogenesis: Development And Utilization Of An In Vivo Imaging Model, Jenna Myr Andrews

Yale Graduate School of Arts and Sciences Dissertations

Coxiella burnetii is a Gram-negative, obligate intracellular bacterium that infects livestock and causes Q fever in humans, which can range from acute flu-like symptoms to severe, persistent infections. C. burnetii relies on a Dot/Icm type IVB secretion system to translocate effector proteins, manipulating host cell processes to support intracellular replication. While axenic media have facilitated in vitro pathogenesis research, in vivo studies remain limited due to the classification of the virulent Nine Mile phase I strain as a category B select agent. Although the avirulent phase II strain RSA493 is exempt from this classification, it is rapidly cleared in immunocompetent …

Contributors, Karin Dejonge-Kannan, Travis N. Thurston, Amanda Deliman, Amanda Morris, Anna Kuthy, Anne Cook, Beth Buyserie, Bethany B. Stone, Caroline Wienhold, Casandra E. Harper, Chris Kilgore, Cynthia Korpan, Elisabeth Schussler, Ferlin Mcgaskey, Gabrielle Stecher Woodward, Hannah Mae Lewis, James Agutter, Janette R. Hill, Jeff Spears, Jim Lamuth, Jordan Shipley, Kate Tregloan, Kim Hales, Letizia Guglielmo, Melissa E. Ko, Michael Morrone, Miranda Yaggi Rodak, Peggy Brickman, Raoul A. Mulder, Shannon M. Sipes, Sharon Lyman, Shihua Brazill, Stephen A. Klien, T. Adam Halstrom, Terri A. Dunbar, Victoria Mondelli, Vijay R. Kannan, Virginia Stormer

Documenting Teaching Excellence

No abstract provided.

The Role Of Sodium Butyrate As An Inflammatory Regulator And Its Effect On Long Noncoding Rnas In Neuroinflammation, Angel Covarrubias

Chemistry & Biochemistry Theses - Archive

Inflammation is a crucial homeostatic process that contributes to both the elimination of foreign invaders and tissue repair. Inflammation at sites of tissue injury or infection is initiated by the detection of a harmful stimulus, triggering vital inflammatory immune signaling pathways and a cascade of cytokines and inflammatory mediators. The dysregulation of this process, however, can result in inappropriate inflammatory responses manifesting in tissue damage and compromised cell function. Dysregulation of the inflammatory response is seen frequently in many human diseases such as Diabetes, Cancer, cardiovascular disease, and neurodegenerative diseases.

In the context of the Central Nervous system, inflammation is …

Returning To School After A Pandemic And The Lived Experiences Of 9-12 Grade Athletic Coaches On Student-Athlete Success, Louie Vallejo

Dissertations

Purpose: This phenomenological examination examines ninth-12th grade athletic coaches’ perceptions of the impact on athletes returning to athletic competition after being online during the pandemic for 2 years with regard to behavior, athletic achievement, attitude, and social connections.

Methodology: This qualitative study interviewed athletic coaches in the Tri-County Athletic Conference in Central California. Semi structured open-ended interview questions were the main source of data collection. Data were coded and the researcher analyzed the data for themes and patterns, and the results were validated through the interrater process by an experienced researcher.

Findings: After analyzing data, codes, and themes, the researcher …

Assessing The Effect Of Increasing The Frequency Of Copd Assessment Test Utilization On Rehospitalization Rates For Home Health Patients, Rebecca Goldberg

West Chester University Doctoral Projects

Abstract

This evidence-based practice Process Improvement (PI) project involves using the COPD Assessment Test (CAT) to decrease rehospitalization rates for home health patients with a diagnosis of Chronic Obstructive Pulmonary Disease (COPD). The project includes having therapy clinicians complete the CAT during their in-home skilled visits, between home health nursing visits to increase the frequency of completion. The goal is to recognize symptoms of exacerbation early, engage patients in their own care, encourage communication with providers, initiate early intervention at home, and prevent rehospitalization. Patients with COPD experience frequent symptom exacerbations leading to anxiety, poor quality of life, and challenges …

Assessing Socioeconomic Differences And Perceptions To Increase The Presence Of Athletic Trainers In Disadvantaged Schools, Sharday Fonseca

West Chester University Doctoral Projects

Student athletes in socioeconomically disadvantaged schools are the least likely to have access to athletic trainers (ATs) because their schools cannot afford them. When ATs are present, they are most likely to identify, treat, and report concussions. Therefore, student athletes in socioeconomically disadvantaged schools are disproportionately impacted by concussion and its potential side effects. This is a qualitative study that used document analysis to conduct a comparative analysis across public schools in Connecticut and surveys to analyze perceptions of athletic staff members. The results of this research indicate that schools that have the most access to ATs (2 employed Full-Time) …

Patient-Centric Barriers To Clinical Trial Participation In Developing Countries: A Retrospective Analysis, Kirandeep Kaur

Master's Theses and Doctoral Dissertations

The underrepresentation of developing countries in clinical trials limits the applicability of research findings to a significant portion of the global population. This study addresses this gap by conducting a retrospective analysis of published literature to identify patient-centric barriers to clinical trial participation in developing countries. A comprehensive search of PubMed, Web of Science, and Cochrane Library databases yielded four relevant studies, which were subjected to thematic analysis. The study identified 12 key emerging themes, with safety and efficacy concerns and trust issues being the most prevalent. The thematic analysis partially supported the hypothesis: While trust issues were found in …

Injection-Related Infections And Self-Treatment Practices Among People Who Inject Drugs In Rural Appalachia, Laura C. Fanucchi, Jennifer R. Havens, Matthew Fahmy, April M. Young

Center on Drug and Alcohol Research Faculty Publications

In this study of self-reported serious injection-related infections among people who inject drugs in rural Appalachia (n = 463), 50% reported reusing syringes/needles, 70.6% ever had an injection-site abscess, and 44.4% of those with a recent abscess took nonprescribed antibiotics. The study identifies opportunities to improve harm reduction services.

Harnessing The Human Gut Microbiota: An Emerging Frontier In Combatting Multidrug-Resistant Bacteria., Wenwen Ding, Yiwen Cheng, Xia Liu, Zhangcheng Zhu, Lingbin Wu, Jie Gao, Wenhui Lei, Yating Li, Xin Zhou, Jian Wu, Yongtao Gao, Zongxin Ling, Ruilai Jiang

Faculty Research 2025

Antimicrobial resistance (AMR) has become a major and escalating global health threat, undermining the effectiveness of current antibiotic and antimicrobial therapies. The rise of multidrug-resistant bacteria has led to increasingly difficult-to-treat infections, resulting in higher morbidity, mortality, and healthcare costs. Tackling this crisis requires the development of novel antimicrobial agents, optimization of current therapeutic strategies, and global initiatives in infection surveillance and control. Recent studies highlight the crucial role of the human gut microbiota in defending against AMR pathogens. A balanced microbiota protects the body through mechanisms such as colonization resistance, positioning it as a key ally in the fight …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2025, Michael Haderle, Kandace Donaldson, Brianna Mortensen, Christina V. Rodriguez, Jill Rothenberg, Bryan Schroeder

Research Annual Reports

Annual research report from the University of New Mexico Health Sciences Center.

Swosu Research And Scholarly Activity Fair 2025, Swosu Office Of Sponsored Programs

SWOSU Research and Scholarly Activity Fair Programs

On behalf of the members of the University Research and Scholarly Activity Committee (USRAC) and the Office of Sponsored Programs (OSP) at Southwestern Oklahoma State University (SWOSU) — welcome to the Thirty-Third SWOSU Research and Scholarly Activity Fair!

This year’s event features 99 poster presentations and 9 oral presentations, showcasing the work of over 170 student and faculty researchers, writers, presenters, artists, collaborators, and faculty sponsors. These presentations represent a wide array of scholarly and academic activity from across SWOSU’s academic community, including the Departments of Art, Communication, and Theatre; Allied Health Sciences; Biological Sciences; Business; Chemistry & …

Life Over Limb: A Case Of Rapidly Rrogressive Necrotizing Fasciitis, Olesya A. Balashova, Adam Lerchenfeld, Rahul Ramakrishnan, Ashley Diaz, Anna Felizcek, Daniel Heller

East Florida Division GME Research Day 2025

No abstract provided.

Predictors Of Dietary Meat Reduction In Gen Z College Students: A Cross-Sectional Survey Using The Com-B Model, Deanne Moosman

Graduate Research Theses & Dissertations

Overconsumption of meat negatively impacts human and environmental health, and these challenges are expected to worsen due to global population growth and increasing meat consumption. Many consumers appear unwilling to reduce their meat intake, and this resistance to dietary change is more common among adult men than women. However, data about meat-eating attitudes and behaviors are lacking for younger generational cohorts. Generation Z (i.e., those born between 1995 and 2010; Gen Z) is a growing consumer group whose dietary decisions will have environmental and human health consequences. Little is known about Gen Z's meat consumption habits and behaviors and whether …

Geographic Patterns Of Human Immunodeficiency Virus (Hiv) Risk Behaviors Among Older Adults: A Strategy For Identifying Space As A Risk Exposure, Laneshia R. Conner, Reuben Adatorwovor, Sarah Jane Robbins, Rujeko O. Machinga-Asaolu, Kathryn Showalter, Carrie B. Oser

Social Work Faculty Publications

Objectives: This study examined geographical patterns of HIV risk among adults aged 60 and older.

Methods: The 2019 Behavioral Risk Factor Surveillance System (BRFSS) weighted data was used to analyze self-reported participation in HIV risk behaviors among older adults (n = 62,852). Logistic regression models were used on a dichotomous HIV risk variable to map the distribution of HIV risk behaviors across both census regions and divisions.

Results: The weighted model revealed significance across regions. Across all regions, identifying as female, identifying as Hispanic, and reporting not having depression were protective from participating in HIV risk behaviors.

Discussion: The …

Digital Chinese Medicine In The Western World: A Conceptual Framework, David C. Mainenti

Selected Full Text Dissertations, 2011-

Digital technology plays an increasing role in Chinese medicine and Western modalities alike. This research uses content analysis and grounded theory for developing a conceptual framework for a digital health system in the Western world termed Digital Chinese Medicine (DCM). Four research questions were proposed: • What are the functional requirements of a DCM system? • What inputs, processes, and outputs are necessary for a DCM system to be both effective and efficient? • What components and features are most desired in a DCM system? • What will a graphical representation of a DCM system look like? Over 475 publications …

Mctr3 Mitigates Cigarette Smoke-Induced Pulmonary Inflammation And Damage, Yu Par Aung Myo

Theses and Dissertations

Smoking is deleterious to our lungs and can precipitate in a multitude of diseases, including chronic obstructive pulmonary disease (COPD). COPD is primarily caused by smoking cigarettes and is a major public health issue. Current therapies only treat symptoms without halting or reversing disease progression, thus highlighting a large unmet need to develop new therapies. We address this gap by investigating maresin conjugate in tissue regeneration 3 (MCTR3) which is a newly discovered specialized pro-resoling mediator (SPM) that has the novel property of promoting tissue repair and regeneration in addition to being anti-inflammatory and pro-resolving. For the first time, we …

Functional Analysis Of Ligand Binding Domain 2 Of Outer Surface Protein C Of Borreliella Burgdorferi, Gavin Z. Chambers

Theses and Dissertations

Lyme disease, caused by the spirochete Borreliella burgdorferi, is the most common vector-borne infection in North America. A critical determinant of early mammalian infection is outer surface protein C (OspC), a highly variable lipoprotein that is indispensable for spirochete survival but whose precise function remains unresolved. OspC has been proposed to mediate diverse roles, including complement evasion, adhesion, tissue dissemination, and antiphagocytic activity, supporting the view that it is a multifunctional virulence factor. Structural studies have identified two putative ligand-binding domains (LBD1 and LBD2), with LBD2 forming a solvent-exposed crown at the membrane-distal end of the OspC dimer.

To …

“Globes" Module (Guiding Learners Towards One Health, Biodiversity, And Environmental Stewardship): Catalyzing Synergies To Advance Leadership And Scholarly Engagement With One Health In Under Graduate Medical Education, Krishna Mohan Surapaneni

Health Professions Education

Background: The concept of One Health addresses the interconnected health of humans, animals, and the environment, offering a critical framework for tackling complex health challenges. However, gaps in the integration of One Health principles into medical education limit the ability of future healthcare providers to operationalize this knowledge in practice. The "GLOBES" module (Guiding Learners towards One health, Biodiversity, and Environmental Stewardship) was designed to bridge these gaps, aligning with Sustainable Development Goals (SDG 3, 13, 14, 15) to promote holistic and interdisciplinary healthcare education. Methods: The "GLOBES" module was developed with 22 competencies across ten categories, incorporating case-based learning, …

The Preferred Leadership Styles Of Generation Z Public Educators, Rex Booth

Murray State Theses and Dissertations

Amid declining enrollments in teacher preparation programs and increasing teacher turnover, understanding the characteristics of Generation Z, who constitute a substantial portion of the future workforce, is critical for effective recruitment and retention in education. This quantitative study explored the preferred leadership styles of Generation Z public educators in western Kentucky using the Multifactor Leadership Questionnaire (MLQ). Specifically, it examined preferences for transformational, transactional, and passive-avoidant leadership styles and assessed whether these preferences varied by race, gender, or years of experience. Results revealed a strong preference for transformational leadership, followed by transactional leadership, with a clear aversion to passive-avoidant approaches. …

Analyzing The Impact Of Geographic Location, Owner Knowledge, And Veterinary Guidance On Equine Vaccination Protocols, Colleen Mcanally

Murray State Theses and Dissertations

This study explored how equine owners decide which diseases their horses are vaccinated for based on their geographic location, the knowledge they have on specific equine diseases, and how much they rely on their veterinarian’s recommendations. A total of 55 horse owners throughout the United States completed an online survey. The results showed that while most owners vaccinate for common core vaccines including West Nile Virus, Tetanus, and Rabies, fewer vaccinated for risk-based vaccines like Leptospirosis. Many owners felt confident in their knowledge of national guidelines for annual core vaccinations, but only a small number of owners were able to …

New Psychoactive Substances Detected In Wastewater Samples Collected Along The Interstate Highway Rest Areas In Kentucky, Durga Prasad Kodati

Murray State Theses and Dissertations

The rapid emergence and proliferation of new psychoactive substances (NPS) pose significant challenges to public health and law enforcement. The potential for abuse and toxicity of these substances, which are intended to mimic the effects of controlled drugs, has been raising concerns as these compounds are designed to evade being regulated. There are traditional methods of tracking NPS, such as seizures and forensic toxicology, but they are delayed and seldom effective because these substances continue to evolve rapidly. Wastewater-based epidemiology (WBE) has emerged as a promising tool for real-time surveillance of drug consumption. The primary objective of this research was …

Intersection Between Individual, Household, Environmental And System Level Factors In Defining Risk And Resilience For Children In Kenya’S Asal: A Qualitative Study, Esther Chongwo, Barack Aoko, Martha Kaniala, Moses Wesala, Phillis Magoma, Eunice Njoroge, Susan Nyamanya, Joyce Marangu, Anil Khamis, Amina Abubakar

Institute for Human Development, East Africa

Introduction: Children growing up in arid and semi-arid regions of Sub-Saharan Africa (SSA) face heightened risks, often resulting in poor developmental outcomes. In Kenya, the arid and semi-arid lands (ASAL) exhibit the lowest health and developmental indicators among children. Despite these risks, some children grow up successfully and overcome the challenges. However, there is limited comprehensive data on sources of risks and resilience in these children, particularly research that incorporates community perspectives and indigenous knowledge. Systematic documentation of factors influencing child outcomes is crucial for understanding the overall burden, informing policy and implementing targeted interventions. This study aimed at …

Tackling The Next Public Health Crisis: Lessons Regarding Long-Term Care From The Covid Era, M. Sara Rosenthal, Keith R. Knapp, Laura Morton

Saint Louis University Journal of Health Law & Policy

This paper reviews multiple ethical and clinical issues during the COVID era affecting long-term care. The authors are members of one of many long-term care COVID task forces[1] that emerged in multiple jurisdictions to address a pandemic emergency. This paper applies the pandemic ethics literature that informed healthcare providers during COVID and recommends adjusting health messaging and communication that may shift responsiveness in the next public health crisis.

[1]. Kentucky Cabinet for Health and Family Services Long-Term Care Advisory Task Force (in alphabetical order): Muhammad Babar, MD, MBA, MSc, CMD, SNF medical director; Belinda Beard, BS, RN, Division Director, …