Digital Commons Network^™

Quantifying The Public Health Impact Of Lyme Disease In Minnesota: A Simulation Analysis Of Reported And Unreported Cases, Kathleen Angell, M. Jana Broadhurst, Jianghu James Dong, Tzeyu L. Michaud, Abraham Degarege, Roberto Cortinas, David Brett-Major

Journal Articles: Epidemiology

Background: Lyme disease, the most common vector-borne disease in Minnesota, is estimated to be underreported by a factor of 10. Delayed diagnosis and misdiagnosis may lead to health complications and increased personal and societal costs. Environmental factors can help to predict high disease years, allowing for early intervention to decrease disease burden. Objective: To estimate the health and cost burdens of Lyme disease and the extent to which they could be diminished by public health intervention when high-incidence Lyme disease years are forecasted. Methods: We used 5 two-dimensional Monte Carlo simulations to estimate (1) average annual expected burden of Lyme …

Covid-19 Risk And Crisis Communication Challenges And Opportunities: Qualitative Insights From Rural Wastewater Surveillance Partners, Savannah Tucker, Beverly May, Matthew Liversedge, Scott M. Berry, James W. Keck, Anna G. Hoover

UK CARES Faculty Publications

Objectives: Understand perceptions of COVID-19 messages and information sources among rural wastewater treatment plant operators to inform context-specific communication strategies for implementing wastewater surveillance methodologies locally.

Methods: Eight employees from 7 Eastern Kentucky facilities involved in SARS-CoV-2 wastewater surveillance participated in semi-structured interviews. Respondents shared perceptions of traditional and social media COVID-19 information channels in their communities, as well as factors influencing trustworthiness of sources. Using the U.S. Centers for Disease Control and Prevention’s Crisis and Emergency Risk Communication (CERC) framework, 3 investigators conducted iterative, thematic coding of interview transcripts.

Results: Respondents’ statements most frequently related to “Be Credible,” “Be …

Silent Signals: Endocarditis Disguised As Low-Back Pain In A Rheumatology Clinic, Ahmad Alomari, Miguel Rodriguez

North Florida Division GME Research Day 2025

No abstract provided.

Mycobacteria Tuberculosis Pericarditis In Immunocompromised Patient, David Benitez, Martin Twumampofo, Aasia Khan, Oscar Garcia

Central & West Texas and San Antonio GME Research Day 2025

No abstract provided.

A Rare Case Of Brucellosis Relapse, Rabia Mahfooz, Grant Patterson, Annmary Behanan, Babivigasan Gunasegaran

Gulf Coast Division GME Research Day 2025

No abstract provided.

René Dubos: An Annotated Bibliography, Carol L. Moberg

René Dubos: An Annotated Bibliography

René Dubos (1901–1982), a prominent 20th century scientist, humanist, and philosopher, was a prolific author. Affiliated for more than 50 years with The Rockefeller Institute for Medical Research/The Rockefeller University, his studies ranged from antibiotics and the role of bacteria in human diseases to formulating broad ecological and environmental questions affecting human health and disease. His seminal writings explore a lifelong belief that a living organism—whether microbe, human being, society, or the Earth itself—could be understood only through its relationships with everything else.

This comprehensive bibliography of more than a thousand works by René Dubos includes brief annotations for each …

Lower Electronic Health Record Adoption And Interoperability In Rural Versus Urban Physician Participants: A Cross-Sectional Analysis From The Cms Quality Payment Program, Alfred J. Anzalone, Carol R. Geary, Ran Dai, Shinobu Watanabe-Galloway, James C. Mcclay, James Campbell

Journal Articles: Epidemiology

BACKGROUND: The Health Information Technology for Economic and Clinical Health Act of 2009 introduced the Meaningful Use program to incentivize the adoption of electronic health records (EHRs) in the U.S. This study investigates the disparities in EHR adoption and interoperability between rural and urban physicians in the context of federal programs like the Medicare Access and CHIP Reauthorization Act of 2015 and the 21st Century Cures Act.

METHODS: A cross-sectional analysis was conducted using the 2021 Quality Payment Program Experience Report Public Use File to compare EHR adoption and Promoting Interoperability scores (PISs) between urban and rural physician participants. Data …

Burnout Among Nurses In The United States, Faheem Ohri

Social Work Dissertations - Archive

Burnout is an exhausted state of the body, mind, and emotions, characterized by feelings of “depersonalization and reduced personal accomplishment” resulting from prolonged and continuous occupational stress. Burnout among nurses in the United States (U.S.) is a growing concern with significant implications for healthcare professionals and patient outcomes. Nurse burnout compromises patient safety and workforce stability, but pre-pandemic national correlates remain understudied. This dissertation examined employment settings and demographic correlates of burnout among U.S. nurses using the National Sample Survey of Registered Nurses (NSSRN) secondary datasets. Compared inpatient burnout odds pre-/post-pandemic using national twin surveys. Jackknife complex survey logistic regression …

Assessing Multi-Hazard Risks And Impacts Of Compound Climate And Weather Extreme Events For Socio-Economic Risk Management, Javed Ali

Graduate Thesis and Dissertation post-2024

In recent decades, compound climate and weather extremes, events driven by multiple drivers such as precipitation, storm surge, river discharge, and waves, have increasingly affected coastal regions, causing severe impacts on human life, infrastructure, ecosystems, and economies. Traditional risk assessments often underestimate these compound events by focusing on individual drivers independently. This dissertation provides a systematic assessment of multi-hazard risks and socio-economic consequences associated with compound events in the coastal counties along the U.S. East and Gulf Coasts. It introduces and applies a novel bottom-up impact-based methodology to assess the role of compound events in causing socio-economic losses in the …

An Exploration And Evaluation Of Biologically Informed Variational Autoencoders For Scrna-Seq Data Analysis, Marjorie R. Principato

Graduate Thesis and Dissertation post-2024

Deep learning has been widely applied to the analysis of high-dimensional biological omics data, especially single-cell RNA sequencing (scRNA-seq). Incorporating biological information into the architecture of variational autoencoders (VAEs) has been shown to enhance model interpretability, allowing the model’s behavior to reflect the underlying mechanisms of the biological system used for its architecture. In recent years, several studies have employed these biologically informed VAEs to model large-scale single-cell transcriptomics data, with models correctly differentiating between cell states and identifying active pathways. However, systematic benchmarking and comparison of different biologically informed VAE architectures remain limited.

In this study, I evaluated and …

Expertise Or Experience: Comparing Discussion Of Drought Between Audiences And Agencies In Nebraska, Kansas, Iowa, And Missouri, Cory L. Armstrong, Sharon E. Baldinelli, Kelly Helm Smith, Sharon J. Medcalf

Journal Articles: Epidemiology

Significant portions of the states in FEMA region 7 (Kansas, Nebraska, Missouri, and Iowa) were in drought in 2022–23. Culling data gathered from a prominent social media platform and from focus group discussions, this research examines how drought information was communicated between the public officials and the general public. Through the lens of the two-step flow of communication theory, the central research question explored the differences between public conversations about drought among individuals experiencing it and the viewpoints of experts who work on drought-related issues. Results from social media conversations were examined, along with insights from focus group discussions involving …

In Silico Prediction Of Cytotoxic T-Cell Epitopes From Helicobacter Pylori Virulence Factors Using An Immunoinformatics Approach, Demy Valerie Chacon, Kiana Alika Co, Daphne Noreen Enriquez, Aubrey Love Labarda

Biology Faculty Publications

Background: Helicobacter pylori infects approximately half of the global population, leading to gastric and duodenal ulcers. Despite the availability of antibiotics, challenges such as patient reluctance, high treatment costs, and antibiotic resistance limit their effectiveness, making vaccination a promising alternative. This study used immunoinformatics to identify candidate epitopes for a multiepitope vaccine construct against H. pylori. Material and methods: The protein variability server was utilized for conservation analysis. The epitopes were screened for antigenicity, allergenicity, toxicity, cross-reactivity, and population coverage. Selected epitopes were docked with their corresponding human leukocyte antigen (HLA) alleles, and thermodynamic quantities were determined. Five virulence factors …

A Low-Cost Production Method For Bst Dna Polymerase (Large Fragment), Crisanto M. Lopez, M. V. San Pedro, V. A. Cañas, J. R. Garcia

Biology Faculty Publications

BstLF, the large fragment of Bst DNA polymerase, is a recombinant strand-displacing DNA polymerase derived from Geobacillus stearothermophilus and serves as the primary enzyme utilized in loopmediated isothermal amplification (LAMP). Recently, the application of LAMP as a convenient and accessible diagnostic tool has gained considerable attention. However, the high cost of reagents presents a significant barrier to the development of LAMP diagnostic kits, limiting accessibility for laboratories in low-resource settings. In this study, we report a low-cost production method for BstLF utilizing more readily available alternative reagents coupled with a simplified purification process. The resulting homebrewed BstLF demonstrated comparable amplification …

Molecular Basis For The Disaggregase Activity Of Protein Disulfide Isomerase, Antonio Mele

Graduate Thesis and Dissertation post-2024

Protein disulfide isomerase (PDI) is an essential, multifunctional, and promiscuous protein with a modular abb’xa’c domain arrangement. Conformational flexibility and the independent, yet coordinated, functionality of PDI domains facilitate protein folding, redox regulation, and the maintenance of cellular homeostasis. Previous investigations have shown that PDI can inhibit amyloid β peptide aggregation, associated with Alzheimer's disease, and is required for cholera toxin disassembly, the rate-limiting step in Vibrio cholerae pathogenesis. However, the precise mechanistic details underlying these interactions remain to be elucidated. Using molecular and biophysical approaches, this study has begun to establish substrate-induced unfolding, or conditional disorder, of PDI as …

Vaccines And Publics: A Variety Of Engagement Experiences, David H. Lee

Publications and Research

This chapter is about some of the sites and scenes where members of the public are exposed to (and engage in) vaccination discourse. To preview, after a brief introduction, we begin with messaging models of communication, followed by the move from messaging to engagement. Next, case examples of public engagement with vaccines are introduced, from pandemic influenza preparedness in the U.S., to polio eradication initiatives in India, and then to COVID-19 public engagement events in England. Settings of public engagement are noted, including online, in churches and museums. Then, there’s a section about communication and public participation, seen as either …

Mycotic Aneurysm And Rare Complication From Infection Masquerading As Lung Cancer, Rithvik Nallapareddy, Mary Anne Nidiry

Books, Presentations, Posters, Etc.

Introduction: Mycotic Aneurysm: Dilation of an arterial wall due to infection • Majority are bacterial, Staphylococcus and Salmonella • Called mycotic because it resembled the appearance of fleshy fungus1 • Most commonly in femoral artery, aorta, and visceral Causes • Form from adjacent bacteria infections • Lung, esophagus, endocarditis • Direct invasion of vessel walls or atherosclerotic plaque in bacteremia General Presentation • Fever, back pain, immunocompromised, IV drug user • Positive blood cultures 50-85%2 • Elevated WBC, ESR, CRP • Lack of standard criteria for diagnosis and management Risk Factors • Tobacco • Atherosclerosis • Diabetes Mellitus Case Presentation: …

Novel Infection By Mucor Hiemalis Kills Caenorhabditis Hosts Through Intestinal Perforation, Jay Ni

West Chester University Graduate Theses, Dissertations, and Final Projects

The nematode Caenorhabditis elegans has emerged as a popular model system to investigate cell biology and host-pathogen interactions. Presently, C. elegans is studied as a natural host of intracellular pathogens such as microsporidia and Orsay virus along with extracellular bacterial and fungal pathogens. The use of C. elegans as a model in host-pathogen research is limited by the number of naturally occurring pathogens to the organism. Through a sampling project to identify new pathogens of C. elegans, we identified the fungus Mucor hiemalis as a pathogen of Caenorhabditis species. We observed the fungus in the intestinal lumen of wild-caught …

Silver Nanoparticles And Vanillin Can Inhibit Collagenase Activities Of Serratia Marcescens, Elaine Vanterpool

Student Posters

Serratia marcescens is a gram-negative, disease-causing agent that belongs to the Enterobacteriaceae family. This rod-shaped microbe causes many infectious diseases such as urinary and respiratory infections, wound infections, and peritonitis, which can result in fatal bacteremia. Protease is a virulence factor of S. marcescens that enhances its pathogenicity by breaking down proteins via cleavage of peptide bonds. The purpose of this research is to identify testing agents that reduce the protease mediated pathogenicity of S. marcescens

A Bibliometric Analysis On Climate Change And Its Implications For Medical Education, Sungkono Sungkono, Firdian Makrufardi, Annisa Fairuz Nur Azizah, Firdiawan Ekaputra

Health Professions Education

This study aims to conduct a comprehensive examination of research in medical education, especially in graduate medical education within the context of climate change. Moreover, this study examined the current research trends on climate change for graduate medical education. The analysis encompasses citation, co-citation, co-occurrence, thematic mapping and evolutionary analyses. Through this bibliometric review, researchers will gain valuable insights by identifying influential publications and understanding the fundamental structure of the field. Additionally, this review paved the way for future studies by highlighting influential research trends and emerging topics. The findings delineate various approaches of discussion based on clusters identified through …

Long Covid And Vulnerability To Climate Change’S Health Effects: An Informational Booklet For Healthcare Settings, Rachel Nussbaum

Public Health Theses

According to the World Health Organization, around 10–20% of people infected by COVID-19 may go on to develop symptoms that can be diagnosed as Long COVID, also known as the post-acute sequelae of COVID-19 (PASC). While the risk of Long Covid among people who received the primary vaccine series fell to 3.5% in one study, as of September 2024, over 1.3 million Americans were being infected with SARS-CoV-2 every day, and reinfections increase the likelihood of experiencing Long Covid in some studies. Continued transmission of SARS-CoV-2 has led to roughly 400 million people experiencing infection-associated chronic conditions, creating an accumulating …

Enhancing Disease Surveillance In Conflict Settings: An Ecological Case Study On Cholera In Sudan At The Intersection Of Environmental And Conflict Drivers, Kinsey Medlin

Public Health Theses

Cholera outbreaks are complex and driven by an interaction of environmental circumstances and conflict-related disruptions, yet few studies have integrated both in the context of conflict regions. This ecological study examines cholera transmission dynamics in Sudan from 2016 to 2025, exploring temporal associations using cross-correlation analysis and applying generalized additive mixed models (GAMMs) to analyze the influence of remotely sensed environmental variables (rainfall, temperature, NDVI, NDWI) and conflict indicators (civilian targeting, political violence, demonstrations) on cholera cases. Weekly cholera surveillance data, combined with satellite-derived environmental variables and conflict event datasets, were modeled across two time periods: pre-conflict (2016-2018) and active …

Cross-Sectional Study On The Distribution And Epidemiology Of Plasmodium Ovale Species In Asymptomatic And Symptomatic Individuals In Gulu, Uganda, Xiaohan Xu

Public Health Theses

Despite global progress in malaria control, Plasmodium ovale remains an under-recognized contributor tothe malaria burden in sub-Saharan Africa. Its ability to form dormant liver-stage hypnozoites enables silent, recurrent transmission that often escapes detection by routine diagnostics. This cross-sectional study investigated the prevalence, species distribution, and clinical profile of P . ovale infections in Gulu, Uganda, comparing asymptomatic individuals from the community to symptomatic patients presenting at Gulu Regional Referral Hospital. Molecular diagnostics, including qPCR, nested PCR, and hemi-nested PCR, were used to detect and differentiate P . ovale curtisi and P . ovale wallikeri. Geographic sampling was conducted across 33 …

Risk Factors Of Respiratory Syncytial Virus (Rsv) Infection In Infants: A Study Using New York State Inpatient And Outpatient Databases, Mengjing Yang

Public Health Theses

Respiratory syncytial virus (RSV) infection is the main cause of respiratory diseases in infants, but the sociodemographic differences in RSV risk have not been fully understood for New York State infants within the first two years of life. This study aims to investigate the distribution and risk factors of respiratory syncytial virus infection in infants and young children under 2 years old in New York State.We conducted a retrospective cohort study using the data from the New York State Inpatient Database (SID) and the State Emergency Department Database (SEDD) from 2016 to 2019. Analyze sociodemographic characteristics, including birth weight, gender, …

The Role Of Climate Change In The Pandemic Agreement Negotiations, Cristina Arnes Sanz

Public Health Theses

Introduction: For over three years, Member States of the World Health Organization (WHO) have been negotiating a treaty to prevent, prepare for, and respond to future pandemics. The Pandemic Agreement is anticipated to be adopted at the World Health Assembly in May 2025. Growing scientific evidence underscores the effects of climate change on infectious diseases, including those that could lead to pandemics. This thesis examines how climate change has been addressed in the drafting and negotiations of the Pandemic Agreement.

Methods: All the references related to climate change in the transcripts of the publicly broadcast Intergovernmental Negotiating Body (INB) meetings …

Modeling Impacts Of Water Improvements On Typhoid In Urban South Asia, Chessley Blacklock-Votava

Public Health Theses

Introduction: Typhoid fever represents a significant burden of disease in urban areas across South Asia. While the recent implementation of routine typhoid conjugate vaccinations (TCVs) has demonstrated significant protective effectiveness against disease, it fails to mitigate environmental transmission through contaminated water, which individuals without access to improved water sources (IWS) may be infected by. Objectives: The primary aim of this study is to estimate the potential reductions to typhoid fever incidence that populations could experience when increasing proportions of the population that have IWS across three high-burden cities in South Asia. The relationship between this reduction and the proportion of …

Icipe Vision And Strategy 2026-2030, International Centre Of Insect Physiology And Ecology (Icipe)

icipe Vision & Strategy

VISION AND STRATEGY

2026 – 2030

“Impacting Nature and Society with Insect Science Solutions for Food, Health and Climate Resilience”

Cronyism In Creating Chronic Disease—A Path To Food Justice, Martha Leonard

St. Thomas Law Review

Central to this discussion is a quote often attributed to the ancient Greek physician Hippocrates: “Let food be thy medicine, and medicine be thy food.” Today, physicians recognize the crucial role of diet in maintaining good health and preventing chronic disease, but U.S. laws fail to reflect this understanding. The health field has seen significant progress in scientific research on pathology; however, nutritional research presents a challenging and contradictory landscape. Corporate influence in scientific research leads to a lack of consensus on the most optimal diet for promoting general health, presenting a challenge for policymaking. The dark reality is that …

Spleen And Peripheral Blood Immunopathology In An Outbred Model Of Adult-Stage Murine Schistosomiasis, Thomas Schulze, Andrew J. Neville, Evie G. Ehrhorn, Sarah A. Alsuleiman, Jonathan L. Vennerstrom, Paul H. Davis

Journal Articles: Pharmaceutical Sciences

Schistosomiasis, a parasitic disease caused by flatworms of genus Schistosoma, is a neglected tropical disease that causes significant morbidity in the developing world. Despite numerous efforts to eradicate the disease, the parasite remains a significant global burden, particularly within Sub-Saharan Africa. Schistosoma species possess an arsenal of potent mechanisms to defend against direct attack from host immune cells and a remarkable ability to modulate the host immune system through proximal and systemic modes that facilitate its stage-specific development, survival, and reproduction. Standardized animal models have been developed that serve as an important resource for dissecting parasite and host immunobiology …

Hist 213-102: The 20th Century World, Elektra Kostopoulou

History Syllabi

No abstract provided.

Acute Hepatitis B Infection In A Patient With Confirmed Immunity On Long-Acting Cabotegravir/Rilpivirine, William K B Boateng, Neil Carlin, Etan Spira, Maria E Szabela, Kosisochukwu J Ezeh

Faculty and Staff Publications

Long-acting injectable formulation of cabotegravir/rilpivirine (CAB/RPV) is a promising novel maintenance therapy for HIV infection. However, coinfection with active hepatitis B virus (HBV) infection is a contraindication to initiating this therapy. Despite guidelines, patients with HBV immunity can still contract acute HBV infection. We report a case of a 30-year-old man with HIV who transitioned from antiretroviral therapy to CAB/RPV and had confirmed HBV immunity. The patient, though asymptomatic, showed significantly elevated liver function tests (LFTs) before his monthly CAB/RPV injection. He was hospitalized and diagnosed with acute HBV infection. His LFTs improved, and he was taken off CAB/RPV and …