Digital Commons Network^™

Flavonoid And Cannabidiol Neural Glyoxalase Pathway Enhancement Against Aging And Alzheimer’S Disease, Joel R. Frandsen

Theses & Dissertations

Alzheimer’s Disease is a neurodegenerative condition featuring neural cell death and a decline in cognitive capacity caused by elevated inflammation and production of reactive oxygen species. The glyoxalase pathway is an endogenous antioxidant system that neutralizes reactive methylglyoxal through sequential reactions. Dysfunction of the glyoxalase pathway contributes to oxidative stress and the accumulation of inflammatory metabolic byproducts. Plant-produced compounds with antioxidant activity can enhance endogenous antioxidant pathways and protect cells from elevated ROS production. We hypothesize that flavonoids and limited Cannabis Sativa-produced cannabidiol can enhance glyoxalase pathway function through regulation of antioxidant and pro-apoptotic signaling pathways to prevent methylglyoxal-mediated …

Examination Of Sleep Disturbance, Anxiety Sensitivity, And Depression In An Undergraduate Sample, Dasha Grace

Honors Theses

Sleep contributes to overall well-being, mental health, and daily functioning. Sleep disturbances negatively affect psychological, physiological, and biological processing, and the quality of sleep is similarly affected by these processes. The effects of sleep disturbance call for a greater understanding of depression and anxiety sensitivity among college students. Studies have found that sleep disturbance affects nearly 90% of the college student population. The aims of the current study were to examine: 1) types and rates of sleep disturbance among a sample of college students, 2) associations between sleep disturbance, AS, and depression symptoms, and 3) AS and depression symptoms by …

The Relationship Between Glucocorticoids And The Humoral Immune Response To Mycoplasma Gallisepticum Challenges In Eastern Bluebirds, Joshua Smith

Honors Theses

Numerous studies have examined relationships between adrenal glucocorticoids and the immune system’s ability to fight disease. The relationship can vary, with glucocorticoids having either stimulatory or inhibitory effects. The pathogenic bacterium Mycoplasma gallisepticum (MG) elicits an adaptive immune response in birds, in which B cells produce MG-specific antibodies to fight the infection and prevent reoccurrence. Previous research found that Eastern Bluebirds that produce the most antibodies in response to MG infection also have the highest glucocorticoid levels. This finding led to the current study investigating whether corticosterone, the primary glucocorticoid in birds, stimulates production of antibodies in response to immune …

Electronic Health Records And Health Information Exchange And Their Impact On International Healthcare System Efficiency, David Pfaehler

Honors Theses

The 19th century epidemiological transition in healthcare caused a major shift in physician focus from curing one-time, deadly illness to managing chronic disease. Now, even the most advanced international healthcare systems must find a way to increase their efficiency in order to compensate for heightened strains on medical systems and swelling costs of healthcare delivery. Fortunately, recent technological innovation and, chiefly, the growth of Electronic Health Records (EHRs) provide a potential solution to this looming threat. EHRs are digital charts with the potential to store and share patient health data among providers to offer the most informed, streamlined care available. …

Comparative Analysis Of National Emergency Management Charters: A Pilot Study Towards Achieving A Standardized Global Emergency Management Framework, Wael Elrayes

Theses & Dissertations

The world is facing increasing risks from a variety of threats, especially those related to extreme weather and natural disasters. The substantial and sustained impacts of major disasters are reinforcing the calls for global collaboration. Nevertheless, worldwide emergency assistance efforts are confronted with several challenges that negatively affect the disaster victims, stress international diplomatic relations, and threaten the social and national security of nations. These challenges arise from the unique nature of each national emergency management framework and the lack of global standardization and governing rules.

We conducted this qualitative study. Using a variety of qualitative analytical methods. we examined …

Patient Assessment And Provider Education Regarding Antibiotic Use In The Treatment Of Viral Uris In The Urgent Care Setting, Ashlee Schoby, Candra D. Hulskotter

Doctor of Nursing Practice Projects

Improving Antibiotic Stewardship Through the Use of Patient Assessment and Provider Education Regarding Treatment of Viral URIs in the Urgent Care Setting

Candra Kronewitter and Ashlee Schoby

Date of Award

Spring 5-2020

Document Type

DNP Project

Project Team Faculty Member

Mary Zerlan, CRNA, DNP, APN

Project Team Faculty Member

Kay Gaehle, PhD

Keywords

Antibiotics, Antibiotic stewardship, URIs, Upper respiratory infections, Urgent care, ABUSE screening tool

Abstract

Antibiotic-resistant bacteria is a growing problem in the United States. The misuse or overuse of antibiotics is being considered the leading cause. Nearly 2-million individuals are infected with resistant bacteria yearly, and antibiotics prescribed …

Influences Of Anti-Bd Bacteria On Amphibians And Their Microbiomes, Emme L. Schmidt

Honors Thesis

The fungal pathogen Batrochochytrium dendrobatidis (Bd) has been threatening amphibian populations across the globe. Recent work has discovered that bacteria isolated from certain populations of amphibians protect hosts from this pathogen. This project focuses on the anti-fungal mechanisms of Serratia marcescens, a species of bacteria isolated from a Costa Rican frog that dramatically inhibited Bd in culture. Wild-type and recombinant S. marcescens was introduced to the microbiomes of a live amphibian host, Acris blanchardi (Blanchard’s Cricket Frog) and then challenged with Bd to examine the protective effects of this bacteria. The experiment includes recombinant S. marcescens with …

Socioeconomic Status And Symptoms Of Anxiety And Depression In Pregnant Women, Meagan Mandabach

Honors Theses

Pregnancy is a period of great change in a woman’s body as her baby develops. During this period, women commonly experience symptoms of anxiety (Dennis et al., 2017) and depression (Shidhaye & Giri, 2014). Literature has suggested that socioeconomic status (SES) can contribute to the severity at which pregnant women experience anxiety and depression (Arora & Aeri, 2019; Field et al., 2008; Shagufta & Shams, 2019), and women of low socioeconomic status may be more likely to experience symptoms of anxiety and depression during pregnancy (Field et al., 2008). The present study aimed to assess the relationships between household income …

Characterization Of A Plasmid-Based Dna Vaccine For Simian Immunodeficiency Virus, Priya Sanipara

Honors Theses

Described as one of the world’s worst pandemics, HIV (Human Immunodeficiency Virus) infects millions of people each year and is the cause for AIDS (Acquired Immunodeficiency Syndrome). Despite the development of vaccines for numerous infectious diseases such as polio, small pox, and influenza, a vaccine for HIV remains elusive due to the virus’s high mutation rate and ability to evade the immune system. HIV causes depletion of CD4+ lymphocytes, resulting in a weakened immune system. However, the development of a plasmid-based DNA vaccine approach may help revolutionize vaccine development for HIV due to its ability to confer cellular and humoral …

Exploring Paramedic Students’ Level Of Preparedness For Disaster Response In Hajj 2019, Nawaf Albaqami

Theses & Dissertations

Objectives: 1) to gain further understanding of the paramedic students' level of preparedness before their clinical training at Hajj. 2) To shed more light on what paramedic students need when responding to a disaster. 3) To determine the need to recommend a change in the current practice with respect

Method: The data collection for this study was a cross-sectional survey using the REDCap electronic data capture tools. It was a convenience sample of 40 respondents. For the analyses, descriptive statistics, including frequencies and percentages, were used, and the Mann Whitney U test.

Results: The main findings in this study were …

2020-05-08_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-08 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Ryen Ormesher, Lauren Tagliaferro Epler, Jenny Situ, Aly Raboff, John Powell, Alexandra Yingling, Cristian Bologa, Tudor I. Oprea, Gregory Mertz, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

UNM drug repurposing. NM cases. Doctors Without Borders. SNAP benefits online. NM 7th highest unemployment. Virtual LemonAid tonight. New N98 masks. Healthcare supply chain challenge. EMS lack resources. Infection risk in healthcare workers. COVID-19 on medical education. Human disinfectant chambers. Evidence of seroconversion. Dangers of considering herd immunity. Wastewater-based surveillance. More youths infected. Reconstructing ship spread. Pharmacoepidemiologic analysis. Clinicopathologic characteristics. Cancer treatment impact. Reduced voluntary psychiatric admission in Italy. Operating room management. Humidifiers reduce transmission. Phone contact tracing ethics. Call for patient database. Immunity certification program. Guidelines on tracheostomy, IBD, nose bleeding, pituitary tumors, and hematopoietic stem cells …

Beware The Book Fair, Allia Zobel Nolan

Erma Bombeck Writers' Workshop Blog

I love book fairs. At least I did until recently. I used to really enjoy discovering all the new titles; what's hot; what's not, meeting with publishers and editors, exchanging chit chat and business cards with new people and connecting with old friends, hugs all around, as they gave me the once-a-year update about their cats and kids.

Projected Deaths Of Despair From Covid-19, Stephen Petterson, John M. Westfall, Benjamin F. Miller

Articles, Abstracts, and Reports

More Americans could lose their lives to deaths of despair, deaths due to drug, alcohol, and suicide, if we do not do something immediately. Deaths of despair have been on the rise for the last decade, and in the context of COVID-19, deaths of despair should be seen as the epidemic within the pandemic. The goal of this report is to predict what deaths of despair we might see based on three assumptions during COVID-19: economic recovery, relationship between deaths of despair and unemployment, and geography. Across nine different scenarios, additional deaths of despair range from 27,644 (quick recovery, smallest …

Scald Injury-Induced T Cell Dysfunction Can Be Mitigated By Gr1+ Cell Depletion And Blockage Of Cd47/Cd172a Signaling, Nadine Beckmann, Franziska Huber, Marc Hanschen, Barbara St. Pierre Schneider, Vanessa Nomelli, Charles C. Caldwell

Nursing Faculty Research

Infection is a common and severe complication of burn injury: Sepsis accounts for 47% of postburn mortality. Burn-induced T cell suppression likely contributes to the increased infection susceptibility in burn patients. However, little is known about the kinetics of T cell dysfunction after burn and its underlying mechanisms. In this study, we show in a murine scald injury model that T cell activation of both CD4+ and CD8+ T cells as well as T cell cytokine production is suppressed acutely and persistently for at least 11 days after burn injury. Purified T cells from scald-injured mice exhibit normal T cell …

Endobronchial Tuberculosis: A Rare Presentation, Nadeem Kassam, Omar M. Aziz, Samina Somji, Grace Shayo

Internal Medicine, East Africa

Endobronchial tuberculosis (EBTB) is an infection of the tracheobronchial tree by Mycobacterium tuberculosis. It is common among young females. Patient can present with fever, cough, wheeze, with or without any constitutional symptoms. It presents as a diagnostic dilemma, as patient sputum smear can be false negative. CT scan may or may not show any abnormality, or any endobronchial lesion. Bronchoscopy with bronchoalveolar lavage and biopsy offers the diagnostic choice. We hereby report a case of a young immunocompetent Asian female who was found to have endobronchial pathology, leading to diagnosis and timely therapy.

Combatting Antibacterial Resistance With Phage Therapy, Linda Line

Thinking Matters Symposium

Phage therapy is the use of viruses to treat bacterial infections. This therapeutic method offers a viable solution to antibiotic resistance among pathogenic bacteria. In this review, we discuss the strengths and weaknesses of phage therapy. Phages attack specific hosts, making them more narrow-spectrum than antibiotics. Adding genes for infection-fighting peptides to the genome may improve the effectiveness of phage therapy. Antimicrobial regulator peptide IDR-1018 is involved in modulation of the immune system. A research group has shown that incorporating a gene for IDR-1018 into phage T7 significantly increased the bactericidal effects in Escherichia coli. In another study, phage lysin …

Cas9 Mediated Gene Drive Might Be The Best Way To Eradicate Malaria Worldwide, Merveidie L. Bayingana

Thinking Matters Symposium

Malaria is a disease caused by a protozoan parasite that is transmitted by the Anopheles female mosquito. Some parts of the world, such as the US, have successfully eliminated malaria, but malaria is still an enormous threat in many African countries. Although efforts exist to prevent and control the spread of malaria, the rate of death it causes is still higher in the poorest countries. The use of impregnated mosquito nets and insecticides do not seem to be enough to stop it. This review of the literature will discuss some genetic approaches to controlling mosquitoes. One such approach has been …

Cardiac Manifestations Of Coronavirus Disease 2019 (Covid-19): A Comprehensive Review, Faryal Tahir, Taha Bin Arif, Jawad Ahmed, Farheen Malik, Muhammad Khalid

Faculty and Staff Publications

Since its origin in China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has become a pandemic and spread to 209 countries. As coronavirus disease 2019 (COVID-19) is a very rapidly emerging disease, organ-specific studies related to it have been reported. Apart from respiratory findings, some studies have highlighted inflammatory consequences in the heart, kidney, and/or liver as well. Cardiac involvement in COVID-19 seems to be a result of an inflammatory storm in response to the infection. Moreover, direct viral invasion of cardiomyocytes, as well as a myocardial injury due to oxidative stress, may account for acute cardiac injury in …

Design And Synthesis Of Novel Analogs As Potential Antitubercular Agents, Peggy Mccluggage

Honors Theses

Tuberculosis (TB) is an infectious, airborne disease which primarily infects the lungs. One-third of the world’s population is currently estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative agent for TB [1]. Current treatment for this disease requires at least six months of taking multiple antibiotics with undesirable side effects [2]. Difficulty in complying to this regimen as well as the prevalence of HIV/AIDS has led to antimicrobial resistance seen in Mtb. In order to combat the Multi-Drug Resistant and Extensively-Drug Resistant strains of the disease-causing bacteria, preventative care and novel antibiotics are urgently needed [3]. The purpose for …

Trp Channels In Cardiovascular Disease, Albert Yu

Doctoral Dissertations

Transient receptor potential (TRP) channels are evolutionarily conserved ion channels that have been implicated in a wide range of physiological and pathophysiological responses. As versatile ion channels that are permeable to calcium, the exact nature of these ion channels have been furiously studied since its initial discovery in Drosophila. Many TRP channels are thought to be gated by PIP2, a well-known membrane signaling molecule. Here we show that membrane potential alters PIP2 in such a way to reduce TRPM7 activity, presumably through PIP2 depletion. This novel mechanism of TRPM7 regulation gives us a clearer picture into a complicated protein that …

Child Marriage In The U.S.: Loopholes In State Marriage Laws Perpetuate Child Marriage, Sarah Ochieng

Immigration and Human Rights Law Review

The practice of child marriage is often discussed in the context of developing countries and many people find it unthinkable that child marriage also occurs in developed countries such as the United States of America. However, child marriage is a serious problem in the United States that affects thousands of children each year. This comment reviews the loopholes in state marriage laws. Part II considers the scope of child marriage as a human rights violation and the effects of child marriage. It also provides a background of the loopholes in state marriage laws, and a focus on the marriage laws …

2020-05-07_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Agent-Based Modeling Of The Hajj Rituals With A Possible Spread Of The Covid-19 (Issue 7, 20 May 2020), Abdessamad Tridane, Hamad Al Jassmi

Covid19 Newsletters

No abstract provided.

2020-05-07 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Mari Anixter, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Emma Wolinsky, Ryen Ormesher, Lauren Tagliaferro Epler, Timothy Campbell, Jenny Situ, Jennifer Thompson, Ryota Shimada, Ariel Hurwitz, Avanika Mahajan, Sandra Boettcher, Alexandra Yingling, Perez Olewe, Cristian Bologa, Gregory Mertz, Krisitne Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM cases. Gallup shutdown extended. Gallup hospital crisis. NM assisted living testing. University student financial relief. FDA fraudulent products. Trump/Pence test negative. India displaced repatriated. Use facemasks. Facemasks cause skin damage. PPE protocol. Michigan reopens. Illegal drug prices up. Failing masks from China. Distribution of remdesivir. CDC PPE video. Low German R0. Stay-at-home lowers Rt. Detention facility epidemiology. Saliva transmission. Healthcare informatics shortcomings. Resource allocation ethics. Uninsured drug discounts. Safer food delivery. Bat coronavirus grant axed. Dispelling common misinformation. Recommendations on managing cardiac arrest, cardiac electrotherapy and electrophysiology, hematologic malignancy, ophthalmologic screening and procedures, the use of ACEIs …

2020-05-07 A Message From Chancellor Roth, Paul B. Roth

HSC Messages from the Chancellor

No abstract provided.

Individualized Mosaics Of Microbial Strains Transfer From The Maternal To The Infant Gut, Jeff Hansen

Browse All News

No abstract provided.

The Society For Immunotherapy Of Cancer Perspective On Regulation Of Interleukin-6 Signaling In Covid-19-Related Systemic Inflammatory Response, Fernanda I. Arnaldez, Steven J. O'Day, Charles G. Drake, Bernard A Fox, Bingqing Fu, Walter Urba, Vincenzo Montesarchio, Jeffrey S. Weber, Haiming Wei, Jon M. Wigginton, Paolo Antonio Ascierto

Articles, Abstracts, and Reports

The pandemic caused by the novel coronavirus SARS-CoV-2 has placed an unprecedented burden on healthcare systems around the world. In patients who experience severe disease, acute respiratory distress is often accompanied by a pathological immune reaction, sometimes referred to as ‘cytokine storm’. One hallmark feature of the profound inflammatory state seen in patients with COVID-19 who succumb to pneumonia and hypoxia is marked elevation of serum cytokines, especially interferon gamma, tumor necrosis factor alpha, interleukin 17 (IL-17), interleukin 8 (IL-8) and interleukin 6 (IL-6). Initial experience from the outbreaks in Italy, China and the USA has anecdotally demonstrated improved outcomes …

Severe Covid-19 Infection In Pregnancy Requiring Intubation Without Preterm Delivery: A Case Report, Leah Hong, Nicolina Smith, Madhurima Keerthy, Monica Lee-Griffith, Robyn Garcia, Majid Shaman, Gregory Goyert

Obstetrics, Gynecology and Women's Health Services Articles

Background: Coronavirus-2019 (COVID-19) is a global health crisis, but there is limited guidance for the critical care management of pregnant patients experiencing respiratory collapse. We describe our management of a peri-viable pregnant patient requiring intubation; discussion includes pharmacologic interventions, mechanical ventilation adjustments, and consideration of fetal interventions, including delivery timing.

Case: A 36-year-old, gravida 2, para 1 woman positive for COVID-19 at 23 weeks of gestation with severe disease required admission to the intensive care unit and intubation. She completed 5 days of hydroxychloroquine and 7 days of prednisone. She was successfully intubated after 8 days and discharged home in …

Novel Role Of Endothelial Derived Exosomal Hspa12b In Regulating Macrophage Inflammatory Responses In Polymicrobial Sepsis, Fei Tu, Xiaohui Wang, Xia Zhang, Tuanzhu Ha, Yana Wang, Min Fan, Kun Yang, P. Spencer Gill, Tammy R. Ozment, Yuan Dai, Li Liu, David L. Williams, Chuanfu Li

ETSU Faculty Works

Endothelial cell dysfunction contributes to sepsis induced initiate immune response and the infiltration of immune cells into organs, resulting in organ injury. Heat shock protein A12B (HSPA12B) is predominantly expressed in endothelial cells. The present study investigated whether endothelial HSPA12B could regulate macrophage pro-inflammatory response during sepsis. Wild type (WT) and endothelial cell-specific HSPA12B deficient (HSPA12B–/–) mice were subjected to CLP sepsis. Mortality and cardiac function were monitored. Higher mortality, worsened cardiac dysfunction, and greater infiltrated macrophages in the myocardium and spleen were observed in HSPA12B–/– septic mice compared with the WT septic mice. The serum levels of TNF-α and …