Digital Commons Network^™

Spillover Of Sars-Cov-2 Into Novel Wild Hosts In North America: A Conceptual Model For Perpetuation Of The Pathogen, Alan B. Franklin, Sarah N. Bevins

United States Department of Agriculture Wildlife Services: Staff Publications

There is evidence that the current outbreak of the novel coronavirus SARS-CoV-2, which causes COVID-19, is of animal origin. As with a number of zoonotic pathogens, there is a risk of spillover into novel hosts. Here, we propose a hypothesized conceptual model that illustrates the mechanism whereby the SARS-CoV-2 could spillover from infected humans to naive wildlife hosts in North America. This proposed model is premised on transmission of SARS-CoV-2 from human feces through municipal wastewater treatment plants into the natural aquatic environment where potential wildlife hosts become infected. We use the existing literature on human coronaviruses, including SARS CoV, …

Unh Archaeologist Receives Prestigious Carnegie Fellowship, Erika Mantz

Media Relations

No abstract provided.

A Rare Presentation Of Coronavirus Disease 2019 (Covid-19) Induced Viral Myositis With Subsequent Rhabdomyolysis., Qian Zhang, Khine S. Shan, Artem Minalyan, Conor O'Sullivan, Travis Nace

Abington Jefferson Health Papers

A 38-year-old gentleman with no significant past medical history but had recent COVID-19 exposure presented to the hospital with the chief complaints of fever, shortness of breath, and generalized myalgia. He was unfortunately found to be severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive. Laboratory findings showed creatine kinase (CK) >42,670 U/L along with elevated inflammatory markers and unremarkable creatinine, cardiac troponin level. The cause of his rhabdomyolysis was discovered to be due to COVID-19 as he had no evidence of other viral infections, strenuous exercise, seizure, or other nontraumatic exertional etiologies. He received aggressive fluid resuscitation while we trended …

What Can We Learn From The 1918 Pandemic? Careful Economics And Policy Lessons From Influenza, Brian J. Asquith

Upjohn Institute Policy Papers

Economists and policymakers have turned to the 1918 Spanish flu for guidance on the COVID-19 crisis, and some have been cheered by the example of its sharp post-pandemic economic recovery. Policymakers have also been encouraged to use lockdowns and school closures (called non-pharmaceutical interventions, or NPIs) in part by research showing that 1918’s NPIs saved lives while aiding the subsequent economic recovery. I review a wide range of research to caution that our own recovery will likely be harder and slower because of how the economy has evolved. I conclude by discussing pro-recovery policy that account for post-1918 economic changes.

Stochastic Simulation Of Cellular Metabolism, Emalie J. Clement, Thomas T. Schulze, Ghada A. Soliman, Beata Joanna Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Increased technological methods have enabled the investigation of biology at nanoscale levels. Such systems require the use of computational methods to comprehend the complex interactions that occur. The dynamics of metabolic systems have been traditionally described utilizing differential equations without fully capturing the heterogeneity of biological systems. Stochastic modeling approaches have recently emerged with the capacity to incorporate the statistical properties of such systems. However, the processing of stochastic algorithms is a computationally intensive task with intrinsic limitations. Alternatively, the queueing theory approach, historically used in the evaluation of telecommunication networks, can significantly reduce the computational power required to generate …

Covid-19 Newsletter (Vol. 14), Center For Disease Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Gw Covid-19 Intelligence Reports: May 11, 2020, George Washington University

GW COVID-19 Intelligence Reports

No abstract provided.

Ppe For Endotracheal Intubation, George Washington University

Intelligence Unit Research Briefs

No abstract provided.

2020-05-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-11 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Melisa Cossé, Susie Pham, Timothy Campbell, Jenny Situ, Randy Ko, Alexandra Yinglng, Elly Munde, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM case counts. Navajo Nation documentary. Medicaid reimbursement increase. Excess NYC mortality. German R0>1. Chile COVID-19 certificates. High female incidence in Quebec. Swab 3D printing. Evidence lacking school reopening. Cloth mask review. WHO 2nd wave warning. Higher mortality in minorities. Environmental transmission controls. Behavior change. Correctional environment guidelines. Wuhan hospital transformation. Maximizing GI training. Threat and conformity. Recommendations on managing COVID-19 (first Italian SARS patients), and obesity and metabolic syndrome. Guidelines for neurologists. Ethics of off-label drugs use. Abbott antibody test approval. CRISPR test FDA approval. Viral sample inactivation. HCQ+azithromycin no benefit. Public-Private partnership for clinical trials. …

The Critical Role Of Tnf Receptors Versus Nadph Oxidase In Controlling Babesia Microti Infection, Amal Balahmar

NYMC Student Theses and Dissertations

Babesia microti is an apicomplexan parasite transmitted by tick bite that infects red blood cells. It is increasingly associated with transfusion-transmitted infections including fatal infection as the parasite survives blood banking procedures. The infection can range from asymptomatic to fatal. The parasite can persist in relatively asymptomatic individuals for up to two years. The host and parasite determinants of severity of infection and/or parasite clearance remain largely unknown. However, asplenic and immune suppressed individuals including the very young and relatively old, greater than 50 years of age, are more vulnerable to severe disease. The goal of the current research is …

Justice Diseased Is Justice Denied: Coronavirus, Court Closures, And Criminal Trials, Ryan Shymansky

West Virginia Law Review Online

This Article aims to consider the immediate impacts of the novel coronavirus on criminal defendants’ access to speedy trials by jury. In particular, it aims to examine whether court closures and delays could affect the substantive rights of criminal defendants—and particularly pretrial detainees—to a speedy and public trial by jury. To date, very little scholarship has considered this question. Yet the ideal of a speedy trial by jury is deeply embedded in our Constitution and our judicial system, and the potential for a pandemic to limit or negate that right should ring scholastic and judicial alarm bells.

This analysis proceeds …

Age Appropriate Wisdom? Ethnobiological Knowledge Ontogeny In Pastoralist Mexican Choyeros, Eric Schniter, Shane J. Macfarlan, Juan J. Garcia, Gorgonio Ruiz-Campos, Diego Guevara Beltran, Brenda B. Bowen, Jory C. Lerbak

ESI Working Papers

We investigate whether age profiles of ethnobiological knowledge development are consistent with predictions derived from life history theory about the timing of productivity and reproduction. Life history models predict complementary knowledge profiles developing across the lifespan for women and men as they experience changes in embodied capital and the needs of dependent offspring. We evaluate these predictions using an ethnobiological knowledge assessment tool developed for an off-grid pastoralist population, known as Choyeros, from Baja California Sur, Mexico. Our results indicate that while individuals acquire knowledge of most dangerous items and edible resources by early adulthood, knowledge of plants and animals …

Screening For Triazole Resistance In Clinically Significant Aspergillus Species; Report From Pakistan, Safia Moin, Joveria Farooqi, Kausar Jabeen, Sidra Laiq, Afia Zafar

Department of Pathology and Laboratory Medicine

Background: Burden of aspergillosis is reported to be significant from developing countries including those in South Asia. The estimated burden in Pakistan is also high on the background of tuberculosis and chronic lung diseases. There is concern for management of aspergillosis with the emergence of azole resistant Aspergillus species in neighbouring countries in Central and South Asia. Hence the aim of this study was to screen significant Aspergillus species isolates at the Microbiology Section of Aga Khan Clinical Laboratories, Pakistan, for triazole resistance.
Methods: A descriptive cross-sectional study, conducted at the Aga Khan University Laboratories, Karachi, from September 2016-May 2019. …

Nurse Expertise: A Critical Resource In The Covid-19 Pandemic Response, Schwerdtle P Nayna, Cj Connell, S Lee, V Plummer, Pl Russo, R Endacott, L Kuhn

School of Nursing and Midwifery

INTRODUCTION. Across the world, nurses, from our unique place within multi-disciplinary health teams are preparing for, working to overcome, or recovering from the first waves of the worst pandemic humanity has seen in a century. While in the media, nurses are predominantly depicted providing direct patient care, we are also well represented at every level of pandemic response from advising governments to leading research, coordinating public health teams, and strategizing humanitarian responses to COVID-19. Nurses comprise the largest component of the health workforce, playing a key role in developing practice, and preserving the core values of health systems globally. Through …

Pandemic Forum Syllabus, Lynda Coon

Pandemic Course

This forum tackles the recent global outbreak of the COVID-19 Coronavirus. University of Arkansas faculty, doctors from Washington Regional Medical Center and Arkansas state leaders confront the virus from a variety of angles —medical sciences, supply chain, public health, social media, mathematics, economics, history, religion, art, and environmental studies. In so doing, the forum’s instructors situate COVID-19 within a broader narrative of the history of pandemics as well as the multivalent factors contributing to virulent flu eruptions across an international stage.

2020-05-10_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-09/10 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Melissa Cossé, Lauren Tagliaferro Epler, Timothy Campbell, Jenny Situ, Aly Raboff, Alexandra Yingling, Perez Olewe, Cristian Bologa, Tudor I. Oprea, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM gets remdesivir. NM case update. Dental services resume. NM prison testing. Educator age risk. Stuart Kauffman dashboard. Long-term care fatalities. Fauci in quarantine. US farmer support. US vaccinations down. South Korea bar shutdown. German rebound lockdown easing. Managing glove skin reactions. Neurosurgery down 70%. Impact airline travel ban. CDC meat packing report. UK distancing impact. 9-day incubation. Low fatality rate estimates. Improving social connection. Social distancing and mask use effective. Parents under stress. Nurse psychological stress. Israel Internal Medicine Tx strategies. Education management. Recommendations are given on endoscopy procedures, management of adrenal insufficiency and of IBD, on …

Even Apart, We Are One, Eric F. Spina

President's Blog: From the Heart

"We are ONE UD. We are one human community." That's the message I delivered at virtual spring degree conferral ceremonies for the Class of 2020. Even apart, we are one.

Predictors Of Willingness Of The Sheltered Homeless To Be Screened For Hepatitis C, Linda Casey

Master's Theses

Background. Homeless individuals are at high risk of contracting the Hepatitis C virus (HCV) given that many use intravenous drugs or have a prison history, common risk factors for the disease. Although there is no vaccine, it is curable.

Methods. This cross-sectional study surveyed residents (n=120) of five homeless shelters in Connecticut to understand their screening willingness and knowledge about HCV.

Results. Those who tested previously (OR=0.46, 95% CI 0.23-0.90) and those who had never spent time in prison (OR=0.39, 95% CI 0.15-0.98) were less willing to be screened. Most did not recognize HCV symptoms and risk factors.

Conclusions. The …

Social Factors Influencing Family Planning Knowledge, Attitudes, And Practices In The Ngäbe Population In Bocas Del Toro And The Comarca Ngäbe-Buglé, Panama, Carolina Vicens Cardona

Master's Theses

Introduction: According to Panama’s 2009 National Sexual and Reproductive Health Survey, only 19% of indigenous women in Panama use modern family planning (FP) methods. Despite the Ngäbe representing 62% of the indigenous population, there is limited research on their use of FP.

Methodology: 14 Ngäbe communities in Bocas del Toro were surveyed. Women between the ages of 18 and 50, and had >2 children completed a survey to assess knowledge, attitudes, and practices regarding family planning.

Results: A total of 148 women were enrolled, mean age was 32.18; mean number of pregnancies was 5. 32.4% of women …

Factors Limiting Effective Coverage Of Indoor Residual Spraying Campaigns In Luapula Province, Zambia, Madeline Mackowski

Theses - ALL

Background.

Malaria transmission control in endemic areas is dependent on both individual

and community level protective measures. Indoor residual spray (IRS) campaigns work to reduce transmission of malaria illness by covering the walls of houses in areas at risk with an insecticide that kills mosquitoes landing there. The World Health Organization recommends IRS campaigns successfully spray at least 80% of structures to maximize impact of the campaigns against malaria vectors.

Methods.

Programmatic data from the 2016 IRS campaign conducted in Luapula Province, Zambia was used to examine the spatial distribution of houses missed during spray campaigns. Additionally, Poisson regression methods …

Nasopharyngeal Isolates From A Cohort Of Medical Students With Or Without Pharyngitis, Hassib Narchi, Junu V. George, Sania M. Al-Hamad, Fawaghi Robari, Mariam Al-Teniji, Hussain Chaqfa, Ahmed Alsuwaidi, Lolowa Al-Mekhaini, Abdul-Kader Souid

Sultan Qaboos University Medical Journal

Objectives: Few studies have investigated pharyngeal colonisation in the United Arab Emirates (UAE). This study aims to identify the pharyngeal organisms present in a cohort of medical students with and without symptomatic pharyngitis. Methods: This study was conducted between September 2016 and June 2018 at the College of Medicine and Health Sciences, UAE University, Al-Ain. Nasopharyngeal swabs were collected from preclinical and clinical medical students attending the college during the study period. The specimens were tested for 16 viral and nine bacterial pathogens using a real-time polymerase chain reaction assay. Results: A total of 352 nasopharyngeal swabs were collected from …

Has Global Health Law Risen To Meet The Covid-19 Challenge? Revisiting The International Health Regulations To Prepare For Future Threats, Lawrence O. Gostin, Roojin Habibi, Benjamin Mason Meier

Georgetown Law Faculty Publications and Other Works

Global health law is essential in responding to the infectious disease threats of a globalizing world, where no single country, or border, can wall off disease. Yet, the Coronavirus Disease (COVID-19) pandemic has tested the essential legal foundations of the global health system. Within weeks, the SARS-CoV-2 coronavirus has circumnavigated the globe, bringing the world to a halt and exposing the fragility of the international legal order. Reflecting on how global health law will emerge in the aftermath of the COVID-19 pandemic, it will be crucial to examine the lessons learned in the COVID-19 response and the reforms required to …

2020-05-09_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Current Student's Deep Reflections On Life During And After The Pandemic, Anonymous Carleton Student

Covid-19 Archive: Documents

In this interview, a Carleton student reflects on what they miss about life at school, the benefits of solidarity, their privilege (stable family), other students' losses, connections to previous historic events, and explains their father's role as an infectious disease doctor, all culminating in total uncertainty for the future.

Identifying Determinants Of Target Specificity In Two Related Bacterial Peptide Toxins, Andrew D. Holmes

Honors Thesis

Toxin-antitoxin (TA) systems were originally identified as two-component systems ensuring the stable inheritance of plasmids in bacterial populations. Recently, they have been identified on bacterial chromosomes where their functions remain mostly undefined. The par locus of E. faecalis plasmid pAD1 (par_pAD1) was the first TA system defined in a Gram-positive bacterium and a homolog encoded on the E. faecalis chromosome (par_EF0409) was later described. Related loci numbering in the hundreds have been identified throughout Gram-positive bacteria based on homology to the toxin of the system, Fst, and similarities in genetic organization and regulation. Despite …

Fundamental Differences In The B Cell Locus, V(D)J Repertoire, And Marburg Virus Epitope Recognition Of The Egyptian Rousette Bat That May Allow For Asymptomatic Presentation, Maggie Linn Bartlett

Theses & Dissertations

Marburg virus (MARV) causes a hemorrhagic fever in humans but is asymptomatic in a known reservoir, the Egyptian rousette bat (Rousettus aegyptiacus, ERB). Understanding the mechanisms that drive these different outcomes could potentially advance the development of therapeutics. The immunoglobulin (Ig) response to MARV infection in ERBs in known to serve a roll in protection. The Ig germline encodes Variable (VH), Diversity (DH), and Joining (JH) genes that then recombine (V(D)J) to make up the binding site of an Ig. Understanding the gene composition of the Ig germline is critical to defining the potential B cell repertoire. We …

Planning And Facilitating The Training Of Emergency Medical Services On The Safe Transport Of Patients With Highly Infectious Diseases, Mohammed Alhallaf

Theses & Dissertations

Emergency Medical Services (EMS) personnel are the first line of treatment and are the first exposed health care workers to infectious diseases (IDs). Consequently, the EMS setting is a relatively vulnerable environment for disease transmission and cross-contamination. Also, serious and emerging IDs, such as highly pathogenic viral hemorrhagic fevers and novel Coronaviruses, in a time of increased globalization, require comprehensive EMS training and preparedness. This project had the objective of identifying best practices for the EMS transport of patients with IDs. The methods for this project were done in two phases. In the first stage, we …

Arginine Biosynthesis In Staphylococcus Aureus, Itidal Reslane

Theses & Dissertations

Staphylococcus aureus causes a wide variety of infections including osteomyelitis, endocarditis, and necrotizing pneumonia. It has been known for decades that S. aureus is auxotrophic for many amino acids including arginine. However, we discovered that after extended incubation, S. aureus can be trained to grow in a defined media lacking arginine. We demonstrate here that this delayed growth is due to the selection of mutations in ahrC, a transcriptional regulator of arginine biosynthesis. A mutation in ahrC mediates the growth of S. aureus in CDM-R by facilitating the biosynthesis of arginine via proline. Mutations in putA and argGH halt the …