Digital Commons Network^™

Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland, S. Travis King, Kayla R. Stover, Kathey Rumley, Shawn H. Macvane, Jenna Swindler, Scott Kincaid, Trisha Branan, David Cluck, Benjamin Britt, Kelly E. Pillinger, Bruce M. Jones, Virginia Fleming, V. Paul Dimondi, Sandy Estrada, Brad Crane, Brian Odle, Majdi N. Al-Hasan, Julie Ann Justo

Faculty Publications

Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Definitive 3GC therapy was compared to definitive therapy with other non-3GC antibiotics. Multivariable Cox proportional hazards regression evaluated the impact of …

Growth Of Herpes Research In The 21st Century: A Scientometric Analysis, Sivankalai S

Library Philosophy and Practice (e-journal)

The virus coined in chimpanzees, flying interested in humans a few million years back. Around two-thirds of the human people are diseased through on minimum single herpes simplex virus. Now this research, we aimed to make a complete scientometric analysis of herpes collected works. We collected data by using four databases provided by Web of Science using the keywords “Herpes”. The study is informative in categorizing and sympathetic trends, including core study areas, author, type of documents, journals, institutions, and countries, and just how these are related, within the existing body of collected works on herpes. A total of 8012 …

Dehydrated Hereditary Stomatocytosis Causing Severe Ascites Leading To Pulmonary Hypoplasia And Respiratory Insufficiency In A Neonate, Michael D. Mcdowell Jr

Research Days

No abstract provided.

2020-05-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Convalescent Plasma Therapy Is Treating Coronavirus Patients In Uab Research, Staff

Browse All News

No abstract provided.

Can Unconventional Immunomodulatory Agents Help Alleviate Covid-19 Symptoms And Severity?, Stephen W. Mamber, Steven Krakowka, Jeffrey L. Osborn, Lloyd Saberski, Ryan G. Rhodes, Albert E. Dahlberg, Sunthorn Pond-Tor, Kara Fitzgerald, Neal Wright, Sarah Beseme, John Mcmichael

Biology Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines, including interleukin-1 (IL-1), IL-6, CCL2 protein, and CXCL10 protein. In the absence of proven antiviral agents or an effective vaccine, substances with immunomodulatory activity may be able to inhibit inflammatory and Th1 cytokines and/or yield an anti-inflammatory and/or Th2 immune response to counteract COVID-19 symptoms and severity. This report briefly describes the following four unconventional but …

Faculty Senate Minutes May 2020, Uno Faculty Senate

Faculty Senate Minutes

These are the official minutes of the Faculty Senate Meetings at the University of Nebraska - Omaha (UNO) for Academic year 2019-2020. The Faculty Senate supports faculty governance and believes that shared governance is essential to creating productive and rewarding environment for faculty and students. The Faculty Senate is a representative body of members elected by the faculty of the various academic departments and units of UNO. The Faculty Senate features representation from each academic college, Criss Library , and Omaha-base University of Nebraska – Lincoln (UNL) colleges.

Evaluating Moose Alces Alces Population Response To Infestation Level Of Winter Ticks Dermacentor Albipictus, Daniel D. Ellingwood, Peter J. Pekins, Henry Jones, Anthony R. Musante

United States Department of Agriculture Wildlife Services: Staff Publications

Many wildlife populations are experiencing a variety of environmental pressures due to the direct and indirect consequences of a changing climate. In the northeast, USA, moose Alces alces are declining in large part because of the increasing parasitism by winter tick Dermacentor albipictus, facilitated by high host density and optimal environmental conditions. To test this hypothesis, and better understand the influence of this interaction on the stability of the regional population, we constructed a population viability model using data collected through comprehensive survival and productivity studies in 2002–2005 and 2014–2018 in northern New Hampshire. Years of heavy tick infestation (epizootics) …

Privilege Of Breaking Into Earth Honored, Jody Record

UNH Today Archive

No abstract provided.

Hypogeusia As The Initial Presenting Symptom Of Covid-19, Lauren E Melley, Eli Bress, Erik Polan

PCOM Scholarly Works

COVID-19 is the disease caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which first arose in Wuhan, China, in December 2019 and has since been declared a pandemic. The clinical sequelae vary from mild, self-limiting upper respiratory infection symptoms to severe respiratory distress, acute cardiopulmonary arrest and death. Otolaryngologists around the globe have reported a significant number of mild or otherwise asymptomatic patients with COVID-19 presenting with olfactory dysfunction. We present a case of COVID-19 resulting in intensive care unit (ICU) admission, presenting with the initial symptom of disrupted taste and flavour perception prior to respiratory …

Commentary: Phytocannabinoids As Therapeutic Agents To Combat Chronic Gingival Disease., Nick Narek Ohanian

Pacific Journal of Health

The therapeutic potential of cannabis has been harnessed for thousands of years yet the United States Food and Drug Administration (FDA) has still not approved cannabis as a safe or effective drug. The FDA has, however, approved the manufacturing of pharmaceutical drugs, which contain a “synthetic version of a substance that is present in the marijuana” and other compounds that mimic its action. A search of the US National Library of Medicine and National Institute of Health for keywords “CBD” and “Periodontitis” together yields only 2 publications. Although the current State and Federal regulations on the use of cannabis for …

When Improper Disposal Leads To More Than Hospital Visits: The Need For A National Standard For Used Medical Sharps, Albana Zherka

William & Mary Environmental Law and Policy Review

No abstract provided.

Volume 6 Full Text, Bjur Staff

Butler Journal of Undergraduate Research

No abstract provided.

Comparison Of Patient Outcomes In A Pharmacist-Led Parenteral Antimicrobial Therapy Program, Zachary W. Howe, Lindsay Saum, Jennifer Mccann

Butler Journal of Undergraduate Research

No abstract provided.

Virus Detections Among Patients With Severe Acute Respiratory Illness, Northern Vietnam, Y. H. Le, K. C. Nguyen, K. K. Coleman, T. T. Nguyen, S. T. Than, H. H. Phan, M. D. Nguyen, N D. Ngu, D. T. Phan, P. V. M. Hoang, L. P. Trieu, T. E. Warkentien, G. C. Gray

Public Health

No abstract provided.

Virus Detections Among Patients With Severe Acute Respiratory Illness, Northern Vietnam, Y. H. Le, K. C. Nguyen, K. K. Coleman, T. T. Nguyen, S. T. Than, H. H. Phan, M. D. Nguyen, N. D. Ngu, D. T. Phan, P. V. M. Hoang, L. P. Triue, E. S. Bailey, T. E. Warkentien, G. C. Gray

Public Health

No abstract provided.

Organizational Risk In Multi-Sector Health Partnerships: A Case Study Of Oregon's Accountable Health Communities, Shauna Jean Nicole Petchel

Dissertations and Theses

The literature on collective action has documented that the perception of organizational risk -- both the uncertainty of potential outcomes and the meaning attached to them -- is an important factor in whether and how organizations engage in cross-sector collaborations. Yet there are few examples to date that document how health and social service leaders perceive organizational risks in cross-sector health partnerships focused on social determinants of health, or how their perceptions influence organizational commitment and willingness to engage in these partnerships over time.

This research aimed to fill this gap through a mixed methods case study of health and …

Sars-Cov-2/Covid-19: Viral Genomics, Epidemiology, Vaccines, And Therapeutic Interventions - Viruses, 2020 (In Press) (Issue 5, 12 May 2020), Farah Mustafa, Tahir A. Rizvi, Tom Loney, Hanan Al Suwaidi, Ahmad H. Al Marzouqi, Afaf Kamal Eldin, Nabeel Alsabeeha, Thomas E. Adrian, Cesare Stefanini, Norbert Nowotny, Alawi Alsheikh-Ali, Abiola C. Senok

Covid19 Newsletters

No abstract provided.

Disruption Of The Electron Transfer System Within The Protein 3-Ketosteroid-9Α-Hydroxylase (Kshab) Of Mycobacterium Tuberculosis, Olivia Esteireiro

Honors Program Theses and Projects

Uncovering the mode of electron transport within the 3-ketosteroid-9-hydroxylase, KshAB, enzyme complex from Mycobacterium tuberculosis will reveal previously unknown possibilities towards curing tuberculosis infections. The KshB protein was mutated at one possible site of electron transfer – an arginine at location 286 – to rupture its cooperation with the KshA complex to prevent the bacteria from gaining energy from the breakdown of steroids as a fuel source. The arginine was mutated to an aspartic acid and alanine to get varying chemical properties to replace the original amino acid. Experimentation included over-expressing the wildtype and mutant proteins in E. coli, …

Spillover Of Sars-Cov-2 Into Novel Wild Hosts In North America: A Conceptual Model For Perpetuation Of The Pathogen, Alan B. Franklin, Sarah N. Bevins

United States Department of Agriculture Wildlife Services: Staff Publications

There is evidence that the current outbreak of the novel coronavirus SARS-CoV-2, which causes COVID-19, is of animal origin. As with a number of zoonotic pathogens, there is a risk of spillover into novel hosts. Here, we propose a hypothesized conceptual model that illustrates the mechanism whereby the SARS-CoV-2 could spillover from infected humans to naive wildlife hosts in North America. This proposed model is premised on transmission of SARS-CoV-2 from human feces through municipal wastewater treatment plants into the natural aquatic environment where potential wildlife hosts become infected. We use the existing literature on human coronaviruses, including SARS CoV, …

Unh Archaeologist Receives Prestigious Carnegie Fellowship, Erika Mantz

Media Relations

No abstract provided.

A Rare Presentation Of Coronavirus Disease 2019 (Covid-19) Induced Viral Myositis With Subsequent Rhabdomyolysis., Qian Zhang, Khine S. Shan, Artem Minalyan, Conor O'Sullivan, Travis Nace

Abington Jefferson Health Papers

A 38-year-old gentleman with no significant past medical history but had recent COVID-19 exposure presented to the hospital with the chief complaints of fever, shortness of breath, and generalized myalgia. He was unfortunately found to be severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive. Laboratory findings showed creatine kinase (CK) >42,670 U/L along with elevated inflammatory markers and unremarkable creatinine, cardiac troponin level. The cause of his rhabdomyolysis was discovered to be due to COVID-19 as he had no evidence of other viral infections, strenuous exercise, seizure, or other nontraumatic exertional etiologies. He received aggressive fluid resuscitation while we trended …

What Can We Learn From The 1918 Pandemic? Careful Economics And Policy Lessons From Influenza, Brian J. Asquith

Upjohn Institute Policy Papers

Economists and policymakers have turned to the 1918 Spanish flu for guidance on the COVID-19 crisis, and some have been cheered by the example of its sharp post-pandemic economic recovery. Policymakers have also been encouraged to use lockdowns and school closures (called non-pharmaceutical interventions, or NPIs) in part by research showing that 1918’s NPIs saved lives while aiding the subsequent economic recovery. I review a wide range of research to caution that our own recovery will likely be harder and slower because of how the economy has evolved. I conclude by discussing pro-recovery policy that account for post-1918 economic changes.

Stochastic Simulation Of Cellular Metabolism, Emalie J. Clement, Thomas T. Schulze, Ghada A. Soliman, Beata Joanna Wysocki, Paul H. Davis, Tadeusz A. Wysocki

Department of Electrical and Computer Engineering: Faculty Publications

Increased technological methods have enabled the investigation of biology at nanoscale levels. Such systems require the use of computational methods to comprehend the complex interactions that occur. The dynamics of metabolic systems have been traditionally described utilizing differential equations without fully capturing the heterogeneity of biological systems. Stochastic modeling approaches have recently emerged with the capacity to incorporate the statistical properties of such systems. However, the processing of stochastic algorithms is a computationally intensive task with intrinsic limitations. Alternatively, the queueing theory approach, historically used in the evaluation of telecommunication networks, can significantly reduce the computational power required to generate …

Covid-19 Newsletter (Vol. 14), Center For Disease Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Gw Covid-19 Intelligence Reports: May 11, 2020, George Washington University

GW COVID-19 Intelligence Reports

No abstract provided.

Ppe For Endotracheal Intubation, George Washington University

Intelligence Unit Research Briefs

No abstract provided.

2020-05-11_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-11 Daily Unm Global Health Covid-19 Briefing, Christophe G. Lambert, Shawn Stoicu, Ingrid Hendrix, Lori D. Sloane, Anastasiya Nestsiarovich, Praveen Kumar, Nicolas Lauve, Lynnmarie Jarratt, Fiona Nguyen, Ryen Ormesher, Melisa Cossé, Susie Pham, Timothy Campbell, Jenny Situ, Randy Ko, Alexandra Yinglng, Elly Munde, Cristian Bologa, Kristine Tollestrup, Orrin Myers, Douglas J. Perkins

HSC Covid 19 Briefings

Executive Summary:

NM case counts. Navajo Nation documentary. Medicaid reimbursement increase. Excess NYC mortality. German R0>1. Chile COVID-19 certificates. High female incidence in Quebec. Swab 3D printing. Evidence lacking school reopening. Cloth mask review. WHO 2nd wave warning. Higher mortality in minorities. Environmental transmission controls. Behavior change. Correctional environment guidelines. Wuhan hospital transformation. Maximizing GI training. Threat and conformity. Recommendations on managing COVID-19 (first Italian SARS patients), and obesity and metabolic syndrome. Guidelines for neurologists. Ethics of off-label drugs use. Abbott antibody test approval. CRISPR test FDA approval. Viral sample inactivation. HCQ+azithromycin no benefit. Public-Private partnership for clinical trials. …

The Critical Role Of Tnf Receptors Versus Nadph Oxidase In Controlling Babesia Microti Infection, Amal Balahmar

NYMC Student Theses and Dissertations

Babesia microti is an apicomplexan parasite transmitted by tick bite that infects red blood cells. It is increasingly associated with transfusion-transmitted infections including fatal infection as the parasite survives blood banking procedures. The infection can range from asymptomatic to fatal. The parasite can persist in relatively asymptomatic individuals for up to two years. The host and parasite determinants of severity of infection and/or parasite clearance remain largely unknown. However, asplenic and immune suppressed individuals including the very young and relatively old, greater than 50 years of age, are more vulnerable to severe disease. The goal of the current research is …