Digital Commons Network^™

Covid-19 In Africa: Care And Protection For Frontline Healthcare Workers, Matthew F. Chersich, Glenda Gray, Lee Fairlie, Quentin Eichbaum, Susannah Mayhew, Brian Allwood, Rene English, Fiona Scorgie, Stanley Luchters, Greg Simpson

Population Health, East Africa

Medical staff caring for COVID-19 patients face mental stress, physical exhaustion, separation from families, stigma, and the pain of losing patients and colleagues. Many of them have acquired SARS-CoV-2 and some have died. In Africa, where the pandemic is escalating, there are major gaps in response capacity, especially in human resources and protective equipment. We examine these challenges and propose interventions to protect healthcare workers on the continent, drawing on articles identified on Medline (Pubmed) in a search on 24 March 2020. Global jostling means that supplies of personal protective equipment are limited in Africa. Even low-cost interventions such as …

Modeling Analysis And Prediction On Ncp Epidemic Transmission, Huaxiong Sheng, Wu Lin, Changliang Xiao

Journal of System Simulation

Abstract: The modeling analysis on the NCP (Novel Coronavirus Pneumonia) epidemic transmission before and after the closure of Wuhan is presented. On the basis of preprocessing the epidemic data, the classical SIR model and differential recurrence method are used to analyze and forecast the epidemic situation in the stage of control. The theoretical value and measured value fits well. In the stage of free transmission, the logistic model is used to compare and analyze the epidemic data five days in advance or later with the actual data to show the importance of taking the epidemic prevention measures in time. The …

Optimization Algorithm Based On Human Infection With Avian Influenza, Guangqiu Huang, Qiuqin Lu

Journal of System Simulation

Abstract: To get the global optimal solution of some complex nonlinear optimization problems, an optimization algorithm based on the human avian influenza infectious diseases is proposed by using its dynamic model of cross species transmission. Applies the H7N9 infectious disease model to create the operators S^u-S^u, I^u-I^u, S^u-I^u, I^u-S^u, S^u-D^u, I^u-D^u, and to enable the individuals to exchange information among the same species and cross-species. The S^u-S^u and I^u-I^u operators …

The Role Of High-Fructose Corn Syrup Imports In Child And Women Obesity, Anna Subirana Bofill

Master's Theses

High Fructose Corn Syrup is believed to be responsible for the increase of the obesity epidemic that is affecting both developed and developing countries, yet to date there are no rigorous analyses that quantify this effect. To estimate the impact of consumption of HFCS on obesity, I have paired country-specific data on imports of HFCS from the United Nations International Trade Statistics Database (UN Comtrade) with women and child health data from around 70 countries from 1985 to 2018. The results show that conditional on space and time fixed effects, imports of HFCS with a high concentration of fructose have …

Lymphatic Filariasis: Host And Parasite Factors And The Pathogenesis Of Systemic Adverse Events Following Treatment, Britt Juul Andersen

Arts & Sciences Graduate Student Theses and Dissertations

Lymphatic filariasis (LF) is a neglected tropical disease caused by the nematode parasites Wuchereria bancrofti, Brugia malayi and B. timori. The primary tool used by the Global Program to Eliminate LF is mass drug administration (MDA), and some 500 million people take the medications each year. Mild to moderate adverse events (AEs) are common after LF treatment, and these pose a major challenge for the LF elimination program. To better understand the pathogenesis of AEs, we studied patients from LF treatment trials in Côte d’Ivoire and Papua New Guinea, where plasma and leucocytes were collected pre and post-treatment and subjects …

Development Of An In Vitro Culture System For Cryptosporidium Parvum, Georgia Wilke

Arts & Sciences Graduate Student Theses and Dissertations

Cryptosporidium is a genus of protozoan parasites that causes diarrheal disease in humans and other animals. There are two major species that cause disease in humans: C. parvum, which infects both humans and animals, and C. hominis, which primarily infects humans. A recent study investigating the etiologies of pediatric diarrheal illness in Africa and South Asia found that Cryptosporidium is the 2nd most prevalent cause of diarrhea in infants and may be a contributing factor to chronic malnutrition. This discovery has led to renewed interest in studying this parasite and a reexamination of the barriers to studying Cryptosporidium. The main …

Conformational Basis And Small Molecule Antagonists Of E. Coli Adhesion To The Urinary Tract, Vasilios Kalas

Arts & Sciences Graduate Student Theses and Dissertations

Urinary tract infections (UTIs) are one of the most prevalent infections, afflicting 15 million women per year in the United States with annual healthcare costs exceeding $2-3 billion. Uropathogenic Escherichia coli (UPEC) are the main etiological agent of UTIs and employ numerous virulence factors for host colonization. The most common adhesive mechanism by which UPEC mediate host-pathogen interactions is the chaperone-usher pathway (CUP), which is responsible for the assembly of proteinaceous surface appendages termed pili. Generally, CUP pili function in adherence or invasion of host tissues and in biofilm formation on medical devices and body habitats. CUP pili are highly …

The Social Dynamics Of Antibiotic Use In A Large American Medical Complex, Katharina Rynkiewich

Arts & Sciences Graduate Student Theses and Dissertations

Based on 18 months of anthropological fieldwork, 35 in-depth interviews, and over 360 hours of participant observation with two specialty physician groups, my dissertation is an analysis of the social dynamics involved in antibiotic decision making, prescription, and use at a large North American medical complex in a Midwestern city. Due to the global problem of antimicrobial resistance, hospitals have been particularly interested in reducing antibiotic overuse and misuse. Though the use of antibiotics has long had an impact at the population level, physicians often advocate for additional antibiotic coverage in the individual patient. I examine a policy aimed at …

In Vivo Mechanisms Of Natural Killer Cell Tolerance, Michael Bern

Arts & Sciences Graduate Student Theses and Dissertations

Natural killer (NK) cells are cytotoxic innate immune cells that provide protection from pathogens and tumors. To carry out these functions, NK cells must distinguish between healthy and unhealthy self-cells. Inability to recognize stressed cells would lead to a failure of NK-cell immunity whereas inability to identify healthy cells could lead to NK-cell autoimmunity. It remains unclear, however, how NK cells are able to distinguish healthy and unhealthy self-cells with a limited repertoire of germline-encoded receptors. The "missing-self" hypothesis proposes that NK cells identify stressed cells by their reduced expression of MHC class I (MHC-I) that is almost ubiquitously expressed …

Building Communities: Interpreting Oneota And Mississipppian Interaction Through Paleoethnobotanical Analysis At The Morton Village Site (11f2), West-Central Illinois, Kelsey Olivia Nordine

Arts & Sciences Graduate Student Theses and Dissertations

Archaeological investigations of social interaction at the community level provide insight into the daily lives of past people and the social structures that guide these community-level interactions. This dissertation uses paleoethnobotanical analysis to examine the nature of social identity negotiation and community at the site-level scale, using data from excavations at the Morton Village site (11F2). Morton Village is a Bold Counselor Oneota and Mississippian settlement in the Central Illinois River Valley (CIRV), occupied contemporaneously by both groups in the 14th century and identified as a multiethnic or multicultural village through the presence of two distinct types of ceramic remains. …

Photographic Validation Of Target Versus Nontarget Take Of Brown Treesnake Baits, Shane R. Siers, Aaron B. Shiels, Cynthia G. Payne, Francinem M. Chlarson, Craig S. Clark, Stephen M. Mosher

United States Department of Agriculture Wildlife Services: Staff Publications

Use of toxic baits or other tools for managing nuisance species must ensure that the species of interest is adequately targeted while exposure to nontarget species is minimized. Nontarget takes of acetaminophen‐laced baits for control of invasive brown treesnakes (Boiga irregularis) on Guam may put those animals at risk of lethal intoxication and render the bait unavailable to the intended target species. We used wildlife cameras to identify species removing toxic and nontoxic baits from brown treesnake bait stations designed to exclude nontarget taxa in 2015 and 2016. Throughout various sites and habitat types, and balanced by season (wet vs. …

Time Allocation To Resources By Three Species Of Rats (Rattus Spp.) In A Radial Arm Maze, Gary Witmer, Nathan P. Snow, Rachael S. Moulton

United States Department of Agriculture Wildlife Services: Staff Publications

Context. Introduced rats (Rattus spp.) can pose a serious threat to native flora and fauna, especially on islands where most species have evolved in the absence of terrestrial predators. Effective detection and eradication methods for introduced rats are essential to the maintenance of insular ecosystem integrity. Thus, it is important to better understand the behaviour of rats when they first arrive in a new setting.

Aims. To determine whether rats would find some novel stimuli to be significantly more attractive than other novel stimuli.

Methods. An eight-arm radial maze was used to study the behaviour of three species of Rattus …

Interactions With Humans Shape Coyote Responses To Hazing, Julie K. Young, Edd Hammill, Stewart W. Breck

United States Department of Agriculture Wildlife Services: Staff Publications

Medium and large carnivores coexist with people in urban areas globally, occasionally resulting in

negative interactions that prompt questions about how to reduce human-wildlife conflict. Hazing,

i.e., scaring wildlife, is frequently promoted as an important non-lethal means for urbanites to reduce

conflict but there is limited scientific evidence for its efficacy. We used a population of captive coyotes (Canis latrans) to simulate urban human-coyote interactions and subsequent effects of hazing on coyote behavior. Past experiences with humans significantly affected the number of times a coyoteapproached a human to necessitate hazing. coyotes that had been hand fed by adults had to …

Hawaii As A Microcosm: Advancing The Science And Practice Of Managing Introduced And Invasive Species, Liba Pejchar, Christopher A. Lepczyk, Jean E. Fantle-Lepczyk, Steven C. Hess, M. Tracy Johnson, Christina R. Leopold, Michael Marchetti, Katherine M. Mcclure, Aaron B. Shiels

United States Department of Agriculture Wildlife Services: Staff Publications

Invasive species are a leading driver of global change, with consequences for biodiversity and society. Because of extraordinary rates of endemism, introduction, and extinction, Hawaii offers a rich platform for exploring the cross-disciplinary challenges of managing invasive species in a dynamic world. We highlight key successes and shortcomings to share lessons learned and inspire innovation and action in and beyond the archipelago. We then discuss thematic challenges and opportunities of broad relevance to invaded ecosystems and human communities. Important research needs and possible actions include eradicating mammals from mainland island sanctuaries, assessing hidden threats from poorly known introduced species, harnessing …

Deciphering Interactions Between White-Tailed Deer And Approaching Vehicle, Morgan Pfeiffer, Raymond B. Iglay, Thomas W. Seamans, Bradley F. Blackwell, Travis L. Devault

United States Department of Agriculture Wildlife Services: Staff Publications

Deer-vehicle collisions are a major transportation hazard, but factors affecting deer escape decision-making in response to vehicle approach remain poorly characterized. We made opportunistic observations of deer response to vehicle approach during daylight hours on a restricted- access facility in Ohio, USA (vehicle speeds were ≤64 km/h). We hypothesized that animal proximity to the road, group size, vehicle approach, and ambient conditions would affect perceived risk by white-tailed deer (Odocoileus virginianus) to vehicle approach, as measured by flight-initiation distance (FID). We constructed a priori models for FID, as well as road-crossing behavior. Deer responses were variable and did not demonstrate …

Provider Education And Rapid Antigen Detection Test Use In Private And Academic Pediatric Clinics, Steven Dahl

Research Days

No abstract provided.

2020-05-14_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Safe Management Of Bodies Of Deceased Persons With Suspected Or Confirmed Covid-19: A Rapid Systematic Review, Sally Yaacoub, Holger J. Schünemann, Joanne Khabsa, Amena El-Harakeh, Assem M. Khamis, Fatimah Chamseddine, Rayane El-Khoury, Zahra Saad, Layal Hneiny, Carlos Cuello Garcia, Giovanna E U Muti-Schünemann, Antonio Bognanni, Chen Chen, Guang Chen, Yuan Zhang, Hong Zhao, Pierre Abi Hanna, Mark Loeb, Thomas Piggott, Marge Reinap, Nesrine Rizk, Rosa Stalteri, Stephanie Duda, Karla Solo, Derek Chu

Faculty Publications

Introduction Proper strategies to minimise the risk of infection in individuals handling the bodies of deceased persons infected with 2019 novel coronavirus (2019-nCoV) are urgently needed. The objective of this study was to systematically review the literature to scope and assess the effects of specific strategies for the management of the bodies.

Methods We searched five general, three Chinese and four coronavirus disease (COVID-19)–specific electronic databases. We searched registries of clinical trials, websites of governmental and other relevant organisations, reference lists of the included papers and relevant systematic reviews, and Epistemonikos for relevant systematic reviews. We included guidance documents providing …

Issue 348: May 2020, The Local Voice

The Local Voice

No abstract provided.

Covid-19 Clinical Update 5/14/2020, George Washington University

GW Infectious Disease Updates

No abstract provided.

The Impact Of Covid-19 On Singapore: Understanding Recent Events And Exploring Future Possibilities, Guanshuo Li

Master's Projects and Capstones

Singapore has among the lowest COVID-19 infection and mortality rates in the world, despite being a major urban country and global economic hub in Southeast Asia. This paper explored how Singapore has accomplished this using an analysis of literature and current events news. The analysis demonstrated that Singapore has mobilized a cross-industry and cross-functioning group of healthcare professionals, medical researchers, biostatisticians, and personal protective equipment manufactures to effectively combat COVID-19. Singapore’s government ministries have enacted a campaign of public education, social distancing, and business closures to combat the spread of COVID-19. The government has passed a significant economic relief bill …

New Rapid Sti Test Will Help Infection Detection, Treatment Strategies, Alicia Rohan

Browse All News

No abstract provided.

Where Are The Good Antibodies Against Covid-19? Uab Project Aims To Find Out, Matt Windsor

Browse All News

No abstract provided.

Initiating Prep In Primary Care: Addressing The Adolescent And Young Adult High Risk Populations, Igor G. Mocorro

Doctor of Nursing Practice (DNP) Projects

Problem: Adolescents and young adults (AYA) ages 13 to 24 comprise a quarter of the new HIV diagnoses in the United States. Lack of access to HIV-preventive therapies such as pre-exposure prophylaxis (PrEP) reduces opportunities to prevent HIV infection in this population. Initiating PrEP in AYA significantly reduces the negative health outcomes of HIV, but it is evident that many clinicians are still reluctant to initiate PrEP in AYA patients based on perceived threats and barriers.

Context: Primary care clinics, including school-based clinics, have an opportunity to offer HIV prevention services including PrEP. This project, the Adolescent and Young Adult …

Minding The Gaps In Regulation Of Do-It-Yourself Biotechnology, Barbara J. Evans

DePaul Journal of Health Care Law

No abstract provided.

Multicenter, Observational Cohort Study Evaluating Third-Generation Cephalosporin Therapy For Bloodstream Infections Secondary To Enterobacter, Serratia, And Citrobacter Species, Caroline Derrick, P. Brandon Bookstaver, Zhiqiang K. Lu, Christopher M. Bland, S. Travis King, Kayla R. Stover, Kathey Rumley, Shawn H. Macvane, Jenna Swindler, Scott Kincaid, Trisha Branan, David Cluck, Benjamin Britt, Kelly E. Pillinger, Bruce M. Jones, Virginia Fleming, V. Paul Dimondi, Sandy Estrada, Brad Crane, Brian Odle, Majdi N. Al-Hasan, Julie Ann Justo

Faculty Publications

Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases the risk of clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates the impact of definitive 3GC therapy versus other antibiotics on clinical outcomes in BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: This multicenter, retrospective cohort study evaluated adult hospitalized patients with BSIs secondary to Enterobacter, Serratia, or Citrobacter species from 1 January 2006 to 1 September 2014. Definitive 3GC therapy was compared to definitive therapy with other non-3GC antibiotics. Multivariable Cox proportional hazards regression evaluated the impact of …

Growth Of Herpes Research In The 21st Century: A Scientometric Analysis, Sivankalai S

Library Philosophy and Practice (e-journal)

The virus coined in chimpanzees, flying interested in humans a few million years back. Around two-thirds of the human people are diseased through on minimum single herpes simplex virus. Now this research, we aimed to make a complete scientometric analysis of herpes collected works. We collected data by using four databases provided by Web of Science using the keywords “Herpes”. The study is informative in categorizing and sympathetic trends, including core study areas, author, type of documents, journals, institutions, and countries, and just how these are related, within the existing body of collected works on herpes. A total of 8012 …

Dehydrated Hereditary Stomatocytosis Causing Severe Ascites Leading To Pulmonary Hypoplasia And Respiratory Insufficiency In A Neonate, Michael D. Mcdowell Jr

Research Days

No abstract provided.

2020-05-13_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Convalescent Plasma Therapy Is Treating Coronavirus Patients In Uab Research, Staff

Browse All News

No abstract provided.