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Validation Of Spatiotemporal And Kinematic Measures In Functional Exercises Using A Minimal Modeling Inertial Sensor Methodology, Benjamin R. Hindle, Justin W.L. Keogh, Anna V. Lorimer

Open Access archive

This study proposes a minimal modeling magnetic, angular rate and gravity (MARG) methodology for assessing spatiotemporal and kinematic measures of functional fitness exercises. Thirteen healthy persons performed repetitions of the squat, box squat, sandbag pickup, shuffle-walk, and bear crawl. Sagittal plane hip, knee, and ankle range of motion (ROM) and stride length, stride time, and stance time measures were compared for the MARG method and an optical motion capture (OMC) system. The root mean square error (RMSE), mean absolute percentage error (MAPE), and Bland–Altman plots and limits of agreement were used to assess agreement between methods. Hip and knee ROM …

Assessing Racial And Ethnic Disparities Using A Covid-19 Outcomes Continuum For New York State, David R. Holtgrave, Meredith A. Barranco, James M. Tesoriero, Debra S. Blog, Eli S. Rosenberg

Publications, Issue Briefs, Reports, Etc

Purpose

Heightened COVID-19 mortality among Black non-Hispanic and Hispanic communities (relative to white non-Hispanic) is well established. This study aims to estimate the relative contributions to fatality disparities in terms of differences in SARS-CoV-2 infections, diagnoses, and disease severity.

Methods

We constructed COVID-19 outcome continua (similar to the HIV care continuum) for white non-Hispanic, Black non-Hispanic, and Hispanic adults in New York State. For each stage in the COVID-19 outcome continua (population, infection experience, diagnosis, hospitalization, fatality), we synthesized the most recent publicly available data. We described each continuum using overall percentages, fatality rates, and relative changes between stages, with …

Cumulative Incidence And Diagnosis Of Sars-Cov-2 Infection In New York, Eli S. Rosenberg, James M. Tesoriero, Elizabeth M. Rosenthal, Rakkoo Chung, Meredith A. Barranco, Linda M. Styer, Monica M. Parker, Shu-Yin John Leung, Johanne E. Morne, Danielle Greene, David R. Holtgrave, Dina Hoefer, Jessica Kumar, Tomoko Udo, Brad Hutton, Howard A. Zucker

Publications, Issue Briefs, Reports, Etc

Purpose

New York State (NYS) is an epicenter of the SARS-CoV-2 pandemic in the United States. Reliable estimates of cumulative incidence in the population are critical to tracking the extent of transmission and informing policies.

Methods

We conducted a statewide seroprevalence study in a 15,101 patron convenience sample at 99 grocery stores in 26 counties throughout NYS. SARS-CoV-2 cumulative incidence was estimated from antibody reactivity by first poststratification weighting and then adjusting by antibody test characteristics. The percent diagnosed was estimated by dividing the number of diagnoses by the number of estimated infection-experienced adults.

Results

Based on 1887 of 15,101 …

Heartland Virus In Lone Star Ticks, Alabama, Usa, Brent C. Newman, William B. Sutton, Abelardo C. Moncayo, Holly R. Hughes, Ali Taheri, Thomas C. Moore, Callie J. Schweitzer, Yong Wang

Agricultural and Environmental Sciences Faculty Research

We detected Heartland virus (HRTV) in lone star nymphs collected in 2018 in northern Alabama, USA. Real-time reverse transcription PCR selective for the small segment of the HRTV genome and confirmatory sequencing of positive samples showed high identity with HRTV strains sequenced from Tennessee and Missouri.

Treatment With Hydroxychloroquine, Azithromycin, And Combination In Patients Hospitalized With Covid-19, Samia Arshad, Paul Kilgore, Zohra S. Chaudhry, Gordon Jacobsen, Dee Dee Wang, Kylie Huitsing, Indira Brar, George J. Alangaden, Mayur S. Ramesh, John E. Mckinnon, William O'Neill, Marcus Zervos, Henry Ford Covid-19 Task Force

Department of Pharmacy Practice

Significance: The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.

Objective: The purpose of this study was to evaluate the role of hydroxychloroquine therapy alone and in combination with azithromycin in hospitalized patients positive for COVID-19.

Design: Multi-center retrospective observational study.

Setting: The Henry Ford Health System (HFHS) in Southeast Michigan: large six hospital integrated health system; the largest of hospitals is an 802-bed quaternary academic teaching hospital in urban Detroit, Michigan.

Participants: Consecutive patients hospitalized with a …

Porcine Cytokines, Chemokines And Growth Factors: 2019 Update, Harry D. Dawson, Yongming Sang, Joan K. Lunney

Agricultural and Environmental Sciences Faculty Research

Pigs are a major food source worldwide as well as major biomedical models for human physiology and therapeutics. A thorough understanding of porcine immunity is essential to prevent and treat infectious diseases, and develop effective vaccines and therapeutics. The use of pigs as biomedical models is dependent on the growing molecular and immune toolbox. This paper summarizes current knowledge of swine cytokines, chemokines and growth factors, identifying 289 pig proteins, characterizing knowledge of their gene structures and families. It identifies areas in the current swine genome build that need to be clarified. A broad-based literature and vendor search was conducted …

Assessment Of The Sexually Transmitted Infection Testing At Lvhn In Symptomatic Patients Who Present To The Emergency Department Or Ambulatory Setting, Sarah Vetesi, Marcelo Gareca Md, Amy Slenker Md

Research Scholars Poster Presentation

No abstract provided.

The Impact Of Multiplex Respiratory Pathogen Pcr Testing At A Large Academic Institution, Hailey Reiss, Jarrod W. Kile Rphd, Bcps, Eric Young Md

Research Scholars Poster Presentation

No abstract provided.

Monarch Science Observer, Volume 5, College Of Sciences, Old Dominion University

College of Sciences Newsletter

August-Summer 2020 issue of Monarch Science Observer, ODU College of Sciences Newsletter.

Understanding Host-Pathogen Interactions, Brett E. Pickett

BYU Research Development Office Research Networking Conference

Gene Expression, Signaling Pathway Analysis, RNA-Sequencing, Drug Repurposing, Infectious Diseases, Diagnostics, Human Diseases, Genome Assembly, Comparative Genomics, Machine Learning

Isu Today- August 18, 2020, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

Isu Special Announcement- August 14, 2020, Indiana State University, Communications And Marketing

University Announcements - ISU Today

No abstract provided.

2020-08-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Comparative Analysis Of Emergency Communication Practices Of Local Public Health Units In Ontario During Covid-19 Pandemic, Thulasika Ledchumikanthan

MPA Major Research Papers

Local Public Health Units play a key role in mitigating the spread of infectious diseases. The COVID-19 pandemic provides an opportunity to leverage the prevalent information communication technologies including social media to communicate with citizens. The aim of this research paper is to conduct a comparative analysis of how methods and content of communication practices across Ontario Public Health Units have differed during the COVID-19 pandemic and explore possible reasons why. Due to the nature of this research being exploratory, a Grounded Theory approach was used. Content analysis included a systematic review of 10 of the 34 public health units’ …

Endothelial Cell Hspa12b And Yes-Associated Protein Cooperatively Regulate Angiogenesis Following Myocardial Infarction, Min Fan, Kun Yang, Xiaohui Wang, Yana Wang, Fei Tu, Tuanzhu Ha, Li Liu, David L. Williams, Chuanfu Li

ETSU Faculty Works

This is an open access article published under the terms of the Creative Commons Attribution 4.0 International License. Angiogenesis is essential for cardiac functional recovery after myocardial infarction (MI). HSPA12B is predominately expressed in endothelial cells and required for angiogenesis. Yes-associated protein (YAP) plays an important role in tumor angiogenesis. This study investigated the cooperative role of HSPA12B and YAP in angiogenesis after MI. Silencing of either HSPA12B or YAP impaired hypoxia-promoted endothelial cell proliferation and angiogenesis. Deficiency of HSPA12B suppressed YAP expression and nuclear translocation after hypoxia. Knockdown of YAP attenuated hypoxia-stimulated HSPA12B nuclear translocation and abrogated HSPA12B-promoted endothelial …

Project Protect Food Systems' Colorado Coronavirus Crisis Essential Food System Worker Policy Response Agenda, Alexia Brunet Marks, Hunter Knapp, Nicole Civita

University of Colorado Law Review Forum

"Revised Colorado Coronavirus Crisis Essential Food System Worker Policy Response Agenda."

Multiomic Immune Clockworks Of Pregnancy, Laura S. Peterson, Ina A. Stelzer, Amy S. Tsai, Mohammad S. Ghaemi, Xiaoyuan Han, Kazuo Ando, Virginia D. Winn, Nadine R. Martinez, Kevin Contrepois, Mira N. Moufarrej, Stephen Quake, David A. Relman, Michael P. Snyder, Gary M. Shaw, David K. Stevenson, Ronald J. Wong, Petra Arck, Martin S. Angst, Nima Aghaeepour, Brice Gaudilliere

All Dugoni School of Dentistry Faculty Articles

Preterm birth is the leading cause of mortality in children under the age of five worldwide. Despite major efforts, we still lack the ability to accurately predict and effectively prevent preterm birth. While multiple factors contribute to preterm labor, dysregulations of immunological adaptations required for the maintenance of a healthy pregnancy is at its pathophysiological core. Consequently, a precise understanding of these chronologically paced immune adaptations and of the biological pacemakers that synchronize the pregnancy “immune clock” is a critical first step towards identifying deviations that are hallmarks of peterm birth. Here, we will review key elements of the fetal, …

Resilience In Nonmetropolitan Nebraska: Capacity To Overcome Disasters And Hardships, 2020 Nebraska Rural Poll Results, Rebecca Vogt, Cheryl Burkhart-Kriesel, Brad Lubben, L.J. Mcelravy, Timothy Meyer, Steve Schulz, Jason L. Weigle

Rural Futures Institute: Publications

The definition of resilience is the capacity to recover quickly from difficulties. Synonyms include toughness, perseverance and grit. Last spring’s severe weather events and this year’s ongoing COVID-19 pandemic are likely testing the resilience of rural Nebraskans. Given that, how do rural Nebraskans rate their communities on dimensions that measure their resiliency? How confident are they that the federal government or local emergency management authorities can contain infectious disease outbreaks? How do they rate their ability to help their community handle adversities? How prepared are rural Nebraskans to deal with financial emergencies? This paper provides a detailed analysis of these …

Health Impacts Of Global Climate Change With A Focus On Women’S Health, Mikhaila Samz

Theses and Graduate Projects

Background: Global climate change has been occurring at an unprecedented rate and is damaging to human health. With women having specific health care needs, this literature review examines the relationship between women’s health (including maternal health) and global climate change through subtopics including global temperature and heat waves, carbon dioxide emissions and air pollution, natural disasters and extreme weather events, malnutrition and food insecurity, water supply and resource scarcity, and changing infectious disease patterns.

Methods: A literature search was conducted across several online databases, predominantly PubMed, for articles related to global climate change and its role in women’s health. The …

Vitamin C As An Adjunct Therapy In Sepsis Management, Nicholas Becker

Theses and Graduate Projects

In the United States, sepsis afflicts nearly one in three ICU patients, is associated with monumental healthcare costs, and is among the leading causes of death. The burden of sepsis is felt globally, and efforts are underway to discover an effective adjunctive therapy. Vitamin C is a novel treatment showing promising early evidence. Additionally, vitamin C's use in combination therapy with hydrocortisone and thiamine has been postulated. These components are thought to work congruently to attenuate the pathophysiologic process of sepsis.

To answer whether vitamin C improves septic patient outcomes, a variety of methods were used to obtain information. Primarily, …

Combating Bacterial Infections With In-Situ Detection And Antibiotic Technology, Paul James Renick

Biology Dissertations - Archive

Currently, there is a looming crisis in the field of antibacterial drug therapy. The emergence of antibacterial drug resistance because of poor antibacterial stewardship, coupled with booming elderly populations, economic disparity and climate change leading to societal instability is undoing the successes of the 20th century in combating infectious disease. New approaches and methods are needed to reverse these trends. My dissertation focuses on three key areas: (1) develop a better understanding of device-related biofilm infections, (2) the use of a bacterial specific D-glutamine positron emission tomography tracer for the direct visualization of infection, and (3) the development of an …

Learning Dynamics From Large Biological Data Sets: Machine Learning Meets Systems Biology, William Gilpin, Yitong Huang, Daniel B. Forger

Mathematics Sciences: Faculty Publications

In the past few decades, mathematical models based on dynamical systems theory have provided new insight into diverse biological systems. In this review, we ask whether the recent success of machine learning techniques for large-scale biological data analysis provides a complementary or competing approach to more traditional modeling approaches. Recent applications of machine learning to the problem of learning biological dynamics in diverse systems range from neuroscience to animal behavior. We compare the underlying mechanisms and limitations of traditional dynamical models with those of machine learning models. We highlight the unique role that traditional modeling has played in providing predictive …

The Use Of Animal-Assisted Therapeutic Interventions In The Hospital Setting During The Covid-19 Pandemic, Alicia Cesare

Graduate Theses/Dissertations

Handlers of therapy and/or facility dogs working within hospital settings have experienced various barriers and challenges within their practice during the COVID-19 pandemic. Animal-assisted interventions, specifically therapeutic working dogs, are a valued source of support to individuals, communities, hospital settings, and disaster sites during times of community distress. The purpose of this study was to identify barriers and solutions to the continued use of animal-assisted therapeutic interventions in support of patients and families within the hospital setting during the COVID-19 pandemic. This researcher’s position within the research is the knowledge and experience of being a facility dog handler within the …

Moral Dilemma Of A Physician And Mother In The Midst Of The Covid-19 Pandemic, Sarah Rosanel, Joshua Fogel

Publications and Research

No abstract provided.

A Novel Correction For The Adjusted Box-Pierce Test — New Risk Factors For Emergency Department Return Visits Within 72 Hours For Children With Respiratory Conditions — General Pediatric Model For Understanding And Predicting Prolonged Length Of Stay, Sidy Danioko

Computational and Data Sciences (PhD) Dissertations

This thesis represents the results of three research projects that underline the breadth and depth of my interests.

Firstly, I devoted some efforts to the well-known Box-Pierce goodness-of-fit tests for time series models which has been an important research topic over the last few decades. All previously proposed tests are focused on changes of the test statistics. Instead, I adopted a different approach that takes the best performing test and modifying the rejection region. Thus, I developed a semiparametric correction of the Adjusted Box-Pierce test that attains the best I error rates for all sample sizes and lags and outperforms …

Cross-Sectional Analysis Of The Relationship Between Violent Crime And Mental Health Disorders In A Sample Of Homeless Adults Recently Released From Jail, Addison Ransom

Dissertations and Theses (Open Access)

Adverse mental health conditions among incarcerated populations are high, and treatment for these conditions is particularly low. Additionally, there is a culture of stigma in the United States towards those with mental health conditions and violent criminal history, contributing to mass incarceration. The present cross-sectional study sought to assess the association between violent criminal history and mental health symptoms among recently incarcerated homeless adults in Dallas, Texas. This study included 230 participants, taking place at The Bridge Homeless Recovery Center, evaluating non-violent versus violent criminal history. Outcome measures of positive screens for post-traumatic stress disorder, generalized anxiety disorder, and depression …

Likelihood Inference For Flexible Cure Rate Models In The Context Of Infectious Diseases With Multiple Exposures, Zachry Joseph Engel

Mathematics Dissertations - Archive

Cure rate models are mostly used to study data arising from cancer clinical trials. Its use in the context of infectious diseases has not been explored well. In 2007, Tournoud and Ecochard rst proposed a mechanistic formulation of cure rate model in the context of infectious diseases with multiple exposures to infection. However, they assumed a simple Poisson distribution to capture the unobserved number of pathogens at each exposure time. In this thesis, we propose a new exible cure rate model to study infectious diseases with discrete multiple exposures to infection. This new model uses the Conway-Maxwell Poisson (COM-Poisson) distribution …

Upholding Tribal Sovereignty And Promoting Tribal Public Health Capacity During The Covid-19 Pandemic, Heather Tanana, Aila Hoss

Utah Law Faculty Scholarship

Tribes are sovereign nations with authorities and responsibilities over their land and people. This inherent sovereign authority includes the right to promote and protect the health and welfare of their communities. The COVID-19 pandemic has brought national attention to the health inequities experienced by American Indian and Alaska Native communities. The sovereign legal authority for Tribes to respond to this pandemic has received less attention. This Chapter describes some, but not all, of the urgent legal issues impacting Tribal response to the COVID-19 pandemic. It describes and identifies gaps in federal Indian health policies and highlights how Tribes have exercised …

Evaluation Of Concurrent Esr And Crp Testing In Native Vertebral Osteomyelitis (Nvo): Is More Really Better?, Noah Kriner, Amy Slenker Md

Research Scholars Poster Presentation

No abstract provided.

Mathematical Modeling, Analysis, And Simulation Of Cholera Dynamics, Chayu Yang

Masters Theses and Doctoral Dissertations

We propose multiple models to investigate the transmission dynamics of cholera. At first, we consider the intrinsic growth of cholera bacteria in cholera transmission and find that the regular threshold dynamics take place if the intrinsic growth is logistic; there are multiple endemic equilibria if the growth exhibits Allee effects, which may lead to backward bifurcation and forward hysteresis. In addition, we introduce a multi-scale modeling framework. At the population level, a Susceptible-Infected-Recovered (SIR) model for the between-host transmission of cholera is employed. At the individual host level, the evolution of the pathogen within the human body is incorporated. The …